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Cheap flights from Des Moines to Roanoke from $329

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Roanoke departing on 5/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Roanoke

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
4:00 pm - 10:58 pm
DSM
-
ROA
5h 58m
1 stop
Delta Logo
7:05 am - 11:47 am
ROA
-
DSM
5h 42m
1 stop
$329Delta
Sat, May 16 - Sat, May 23
American Airlines Logo
7:34 am - 5:20 pm
DSM
-
ROA
8h 46m
2 stops
American Airlines Logo
5:50 pm - 10:27 pm
ROA
-
DSM
5h 37m
1 stop
$334American Airlines
Wed, Sep 16 - Mon, Sep 21
Delta Logo
4:00 pm - 10:58 pm
DSM
-
ROA
5h 58m
1 stop
Delta Logo
6:00 am - 11:08 am
ROA
-
DSM
6h 08m
1 stop
$349Delta
Sat, May 16 - Sat, May 23
American Airlines Logo
1:41 pm - 9:20 pm
DSM
-
ROA
6h 39m
1 stop
American Airlines Logo
7:58 pm - 12:06 am
ROA
-
DSM
5h 08m
1 stop
$380American Airlines
Wed, Jul 29 - Sat, Aug 1
American Airlines Logo
8:43 am - 5:17 pm
DSM
-
ROA
7h 34m
2 stops
American Airlines Logo
7:58 pm - 12:17 am
ROA
-
DSM
5h 19m
1 stop
$394American Airlines
Fri, May 29 - Mon, Jun 1
United Airlines Logo
6:00 am - 1:33 pm
DSM
-
ROA
6h 33m
1 stop
United Airlines Logo
6:40 am - 10:22 am
ROA
-
DSM
4h 42m
1 stop
$409United Airlines
Thu, Jul 2 - Sun, Jul 5
United Airlines Logo
11:40 am - 11:44 pm
DSM
-
ROA
11h 04m
2 stops
United Airlines Logo
6:40 am - 10:27 am
ROA
-
DSM
4h 47m
1 stop
$414United Airlines
Sat, May 16 - Sat, May 23
United Airlines Logo
5:00 am - 1:33 pm
DSM
-
ROA
7h 33m
1 stop
United Airlines Logo
6:40 am - 10:22 am
ROA
-
DSM
4h 42m
1 stop
$429United Airlines
Thu, Jul 2 - Sun, Jul 5
United Airlines Logo
6:00 am - 1:55 pm
DSM
-
ROA
6h 55m
2 stops
United Airlines Logo
6:40 am - 10:22 am
ROA
-
DSM
4h 42m
1 stop
$434United Airlines
Thu, Jul 2 - Sun, Jul 5
American Airlines Logo
1:41 pm - 10:18 pm
DSM
-
ROA
7h 37m
1 stop
American Airlines Logo
8:10 am - 12:34 pm
ROA
-
DSM
5h 24m
1 stop
$438American Airlines
Thu, Jul 2 - Sun, Jul 5

United Airlines flights from Des Moines to Roanoke

Our best United Airlines deals on Des Moines to Roanoke flight tickets
United Airlines
Jul 2
DSM6:00 amDes Moines
6h 33m
1 stop
ROA1:33 pmRoanoke
Jul 5
ROA6:40 amRoanoke
4h 42m
1 stop
DSM10:22 amDes Moines
$409
United Airlines
May 16
DSM11:40 amDes Moines
11h 04m
2 stops
ROA11:44 pmRoanoke
May 23
ROA6:40 amRoanoke
4h 47m
1 stop
DSM10:27 amDes Moines
$414
United Airlines
Jul 2
DSM5:00 amDes Moines
7h 33m
1 stop
ROA1:33 pmRoanoke
Jul 5
ROA6:40 amRoanoke
4h 42m
1 stop
DSM10:22 amDes Moines
$429

Delta flights from Des Moines to Roanoke

Our best Delta deals on Des Moines to Roanoke flight tickets
Delta
May 16
DSM4:00 pmDes Moines
5h 58m
1 stop
ROA10:58 pmRoanoke
May 23
ROA7:05 amRoanoke
5h 42m
1 stop
DSM11:47 amDes Moines
$329
Delta
May 16
DSM4:00 pmDes Moines
5h 58m
1 stop
ROA10:58 pmRoanoke
May 23
ROA6:00 amRoanoke
6h 08m
1 stop
DSM11:08 amDes Moines
$349

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Roanoke that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 13, 2026.
Use the filters below to find and compare flights from Des Moines to Roanoke that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Sat 5/16

4:00 pm-10:58 pm

1 stop5h 58m

Roanoke

Sat 5/23

7:05 am-11:47 am

1 stop5h 42m

$329

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Wed 9/16

7:34 am-5:20 pm

2 stops8h 46m

Roanoke

Mon 9/21

5:50 pm-10:27 pm

1 stop5h 37m

$334

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Sat 5/16

4:00 pm-10:58 pm

1 stop5h 58m

Roanoke

Sat 5/23

6:00 am-11:08 am

1 stop6h 08m

$349

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Wed 7/29

1:41 pm-9:20 pm

1 stop6h 39m

Roanoke

Sat 8/1

7:58 pm-12:06 am

1 stop5h 08m

$380

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Fri 5/29

8:43 am-5:17 pm

2 stops7h 34m

Roanoke

Mon 6/1

7:58 pm-12:17 am

1 stop5h 19m

$394
Quickest round-trip

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Thu 7/2

6:00 am-1:33 pm

1 stop6h 33m

Roanoke

Sun 7/5

6:40 am-10:22 am

1 stop4h 42m

$409

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Sat 5/16

11:40 am-11:44 pm

2 stops11h 04m

Roanoke

Sat 5/23

6:40 am-10:27 am

1 stop4h 47m

$414

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Thu 7/2

5:00 am-1:33 pm

1 stop7h 33m

Roanoke

Sun 7/5

6:40 am-10:22 am

1 stop4h 42m

$429

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Thu 7/2

6:00 am-1:55 pm

2 stops6h 55m

Roanoke

Sun 7/5

6:40 am-10:22 am

1 stop4h 42m

$434

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Thu 7/2

1:41 pm-10:18 pm

1 stop7h 37m

Roanoke

Sun 7/5

8:10 am-12:34 pm

1 stop5h 24m

$438

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Roanoke from

How to get the cheapest flight ticket from Des Moines to Roanoke

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Roanoke?

When to book flights from Des Moines to Roanoke

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Roanoke according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Roanoke (DSM to ROA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Roanoke

Fastest flight time

4h 24m

Direct flights

None
The fastest flight from Des Moines to Roanoke takes 4h 24m
There are no direct flights from Des Moines to Roanoke. There are no popular flight routes from Des Moines to Roanoke.
Search flight deals

Frequently asked questions about flying from Des Moines to Roanoke

  • How far is Des Moines to Roanoke by plane?

    The distance between Des Moines and Roanoke is about 787.3 mi. Typically, this will take 4h 24m by plane in normal conditions.

  • When did momondo last update prices for flights from Des Moines Airport to Roanoke Airport?

    Prices for flights from Des Moines Airport to Roanoke Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Roanoke Airport?

  • How old do you have to be to fly from Des Moines Airport to Roanoke Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Roanoke Airport.

  • What documentation or ID do you need to fly to Roanoke Airport?

    The necessary travel and health documents for your Roanoke Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Roanoke?

Best airlines flying from Des Moines to Roanoke

Compare and see reviews for airlines that fly from Des Moines to Roanoke with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $248Free CancellationRating
7.9
8,406 reviews
Search Delta flights
American AirlinesPriceFrom $258Free CancellationRating
7.1
11,569 reviews
Search American Airlines flights

Traveling to a place near Roanoke?

Book flights to Roanoke if you plan to visit one of these locations
Blacksburg
Salem
Christiansburg
Radford
Rocky Mount

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Roanoke?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Roanoke. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Roanoke with flexible booking policies on momondo?

Flights from Des Moines to Roanoke with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Roanoke?

momondo helps you find the best flight between Des Moines and Roanoke by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Roanoke right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Roanoke, momondo offers a useful price alert feature which will track prices for flights to Roanoke from Des Moines and alert you when they change.

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