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Cheap flights from Des Moines to Roanoke from $229

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Roanoke departing on 3/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Roanoke

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
7:04 pm - 12:22 am
DSM
-
ROA
4h 18m
1 stop
United Airlines Logo
6:45 am - 10:44 am
ROA
-
DSM
4h 59m
1 stop
$269United Airlines
Thu, Apr 16 - Sun, Apr 19
Delta Logo
12:29 pm - 12:04 am
DSM
-
ROA
10h 35m
2 stops
Delta Logo
6:00 am - 11:05 am
ROA
-
DSM
6h 05m
1 stop
$274Delta
Sat, Apr 11 - Sat, Apr 18
United Airlines Logo
2:04 pm - 8:40 pm
DSM
-
ROA
5h 36m
1 stop
United Airlines Logo
6:40 am - 1:23 pm
ROA
-
DSM
7h 43m
1 stop
$279United Airlines
Tue, Mar 10 - Sat, Mar 14
United Airlines Logo
8:00 am - 7:02 pm
DSM
-
ROA
10h 02m
2 stops
United Airlines Logo
6:40 am - 1:23 pm
ROA
-
DSM
7h 43m
1 stop
$284United Airlines
Tue, Mar 10 - Sat, Mar 14
American Airlines Logo
5:01 pm - 12:14 am
DSM
-
ROA
6h 13m
1 stop
American Airlines Logo
3:10 pm - 9:58 pm
ROA
-
DSM
7h 48m
1 stop
$289American Airlines
Sat, May 16 - Sat, May 23
Delta Logo
6:31 pm - 12:25 am
DSM
-
ROA
4h 54m
1 stop
Delta Logo
6:00 am - 11:05 am
ROA
-
DSM
6h 05m
1 stop
$319Delta
Wed, Apr 15 - Sun, Apr 19
United Airlines Logo
7:04 pm - 12:22 am
DSM
-
ROA
4h 18m
1 stop
United Airlines Logo
6:45 am - 10:44 am
ROA
-
DSM
4h 59m
1 stop
$339United Airlines
Thu, Apr 16 - Sun, Apr 19
United Airlines Logo
1:32 pm - 12:22 am
DSM
-
ROA
9h 50m
2 stops
United Airlines Logo
6:45 am - 10:44 am
ROA
-
DSM
4h 59m
1 stop
$370United Airlines
Thu, Apr 16 - Sun, Apr 19
American Airlines Logo
5:00 am - 4:33 pm
DSM
-
ROA
10h 33m
2 stops
American Airlines Logo
8:15 am - 6:19 pm
ROA
-
DSM
11h 04m
2 stops
$377American Airlines
Tue, Mar 10 - Sat, Mar 14
United Airlines Logo
7:04 pm - 12:22 am
DSM
-
ROA
4h 18m
1 stop
United Airlines Logo
7:59 pm - 10:44 am
ROA
-
DSM
15h 45m
2 stops
$416United Airlines
Thu, Apr 16 - Mon, Apr 20

United Airlines flights from Des Moines to Roanoke

Our best United Airlines deals on Des Moines to Roanoke flight tickets
United Airlines
Apr 16
DSM7:04 pmDes Moines
4h 18m
1 stop
ROA12:22 amRoanoke
Apr 19
ROA6:45 amRoanoke
4h 59m
1 stop
DSM10:44 amDes Moines
$269
United Airlines
Mar 10
DSM2:04 pmDes Moines
5h 36m
1 stop
ROA8:40 pmRoanoke
Mar 14
ROA6:40 amRoanoke
7h 43m
1 stop
DSM1:23 pmDes Moines
$279
United Airlines
Mar 10
DSM8:00 amDes Moines
10h 02m
2 stops
ROA7:02 pmRoanoke
Mar 14
ROA6:40 amRoanoke
7h 43m
1 stop
DSM1:23 pmDes Moines
$284

American Airlines flights from Des Moines to Roanoke

Our best American Airlines deals on Des Moines to Roanoke flight tickets
American Airlines
May 16
DSM5:01 pmDes Moines
6h 13m
1 stop
ROA12:14 amRoanoke
May 23
ROA3:10 pmRoanoke
7h 48m
1 stop
DSM9:58 pmDes Moines
$289
American Airlines
Mar 10
DSM5:00 amDes Moines
10h 33m
2 stops
ROA4:33 pmRoanoke
Mar 14
ROA8:15 amRoanoke
11h 04m
2 stops
DSM6:19 pmDes Moines
$377
American Airlines
May 15
DSM6:00 amDes Moines
17h 14m
1 stop
ROA12:14 amRoanoke
May 18
ROA7:28 amRoanoke
17h 21m
1 stop
DSM11:49 pmDes Moines
$433

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Roanoke that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 26, 2026.
Use the filters below to find and compare flights from Des Moines to Roanoke that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Thu 4/16

7:04 pm-12:22 am

1 stop4h 18m

Roanoke

Sun 4/19

6:45 am-10:44 am

1 stop4h 59m

$269

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Sat 4/11

12:29 pm-12:04 am

2 stops10h 35m

Roanoke

Sat 4/18

6:00 am-11:05 am

1 stop6h 05m

$274

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Tue 3/10

2:04 pm-8:40 pm

1 stop5h 36m

Roanoke

Sat 3/14

6:40 am-1:23 pm

1 stop7h 43m

$279

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Tue 3/10

8:00 am-7:02 pm

2 stops10h 02m

Roanoke

Sat 3/14

6:40 am-1:23 pm

1 stop7h 43m

$284

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Sat 5/16

5:01 pm-12:14 am

1 stop6h 13m

Roanoke

Sat 5/23

3:10 pm-9:58 pm

1 stop7h 48m

$289

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Wed 4/15

6:31 pm-12:25 am

1 stop4h 54m

Roanoke

Sun 4/19

6:00 am-11:05 am

1 stop6h 05m

$319

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Thu 4/16

7:04 pm-12:22 am

1 stop4h 18m

Roanoke

Sun 4/19

6:45 am-10:44 am

1 stop4h 59m

$339

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Thu 4/16

1:32 pm-12:22 am

2 stops9h 50m

Roanoke

Sun 4/19

6:45 am-10:44 am

1 stop4h 59m

$370

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Tue 3/10

5:00 am-4:33 pm

2 stops10h 33m

Roanoke

Sat 3/14

8:15 am-6:19 pm

2 stops11h 04m

$377

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Thu 4/16

7:04 pm-12:22 am

1 stop4h 18m

Roanoke

Mon 4/20

7:59 pm-10:44 am

2 stops15h 45m

$416

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Des Moines to Roanoke

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Des Moines to Roanoke?

American Airlines and United Airlines are the most popular carriers operating from Des Moines to Roanoke

When to book flights from Des Moines to Roanoke

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Roanoke according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Roanoke (DSM to ROA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Roanoke

Fastest flight time

4h 18m

Direct flights

None
The fastest flight from Des Moines to Roanoke takes 4h 18m
There are no direct flights from Des Moines to Roanoke. There are no popular flight routes from Des Moines to Roanoke.
Search flight deals

  • How far is Des Moines to Roanoke by plane?

    The distance between Des Moines and Roanoke is about 787.3 mi. Typically, this will take 4h 18m by plane in normal conditions.

  • When did momondo last update prices for flights from Des Moines Airport to Roanoke Airport?

    Prices for flights from Des Moines Airport to Roanoke Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Roanoke Airport?

  • How old do you have to be to fly from Des Moines Airport to Roanoke Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Roanoke Airport.

  • What documentation or ID do you need to fly to Roanoke Airport?

    The necessary travel and health documents for your Roanoke Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Roanoke?

Best airlines flying from Des Moines to Roanoke

Compare and see reviews for airlines that fly from Des Moines to Roanoke with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,352 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,237 reviews
Search Delta flights

Traveling to a place near Roanoke?

Book flights to Roanoke if you plan to visit one of these locations
Blacksburg
Salem
Christiansburg
Radford
Rocky Mount

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Roanoke?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Roanoke. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Roanoke with flexible booking policies on momondo?

Flights from Des Moines to Roanoke with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Roanoke?

momondo helps you find the best flight between Des Moines and Roanoke by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Roanoke right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Roanoke, momondo offers a useful price alert feature which will track prices for flights to Roanoke from Des Moines and alert you when they change.

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