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Cheap flights from Des Moines to Roanoke from $339

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Roanoke departing on 6/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Des Moines to Roanoke

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
4:00 pm - 10:58 pm
DSM
-
ROA
5h 58m
1 stop
Delta Logo
6:00 am - 10:43 am
ROA
-
DSM
5h 43m
1 stop
$339Delta
Sat, Jun 6 - Wed, Jun 10
Delta Logo
5:00 pm - 12:32 am
DSM
-
ROA
6h 32m
1 stop
Delta Logo
6:00 am - 10:45 am
ROA
-
DSM
5h 45m
1 stop
$354Delta
Thu, Jul 2 - Sun, Jul 5
United Airlines Logo
3:24 pm - 9:03 pm
DSM
-
ROA
4h 39m
1 stop
United Airlines Logo
6:40 am - 10:17 am
ROA
-
DSM
4h 37m
1 stop
$369United Airlines
Fri, Jul 24 - Thu, Jul 30
American Airlines Logo
1:41 pm - 9:20 pm
DSM
-
ROA
6h 39m
1 stop
American Airlines Logo
5:46 pm - 10:45 pm
ROA
-
DSM
5h 59m
1 stop
$379American Airlines
Thu, Jul 2 - Sun, Jul 5
United Airlines Logo
1:35 pm - 11:43 pm
DSM
-
ROA
9h 08m
2 stops
United Airlines Logo
7:00 am - 12:30 pm
ROA
-
DSM
6h 30m
1 stop
$394United Airlines
Sat, Oct 24 - Wed, Oct 28
United Airlines Logo
3:11 pm - 11:43 pm
DSM
-
ROA
7h 32m
2 stops
United Airlines Logo
11:00 am - 8:32 pm
ROA
-
DSM
10h 32m
2 stops
$399United Airlines
Sat, Oct 24 - Wed, Oct 28
United Airlines Logo
11:23 am - 11:44 pm
DSM
-
ROA
11h 21m
2 stops
United Airlines Logo
6:40 am - 10:17 am
ROA
-
DSM
4h 37m
1 stop
$404United Airlines
Fri, Jul 24 - Thu, Jul 30
United Airlines Logo
3:11 pm - 10:59 pm
DSM
-
ROA
6h 48m
1 stop
United Airlines Logo
5:38 pm - 11:01 pm
ROA
-
DSM
6h 23m
1 stop
$410United Airlines
Sat, Oct 24 - Wed, Oct 28
American Airlines Logo
5:00 am - 1:51 pm
DSM
-
ROA
7h 51m
2 stops
American Airlines Logo
6:02 pm - 12:12 am
ROA
-
DSM
7h 10m
1 stop
$431American Airlines
Sat, Jun 6 - Wed, Jun 10
American Airlines Logo
1:33 pm - 7:49 pm
DSM
-
ROA
5h 16m
1 stop
American Airlines Logo
7:58 pm - 12:12 am
ROA
-
DSM
5h 14m
1 stop
$434American Airlines
Wed, Jun 10 - Sun, Jun 14

United Airlines flights from Des Moines to Roanoke

Our best United Airlines deals on Des Moines to Roanoke flight tickets
United Airlines
Jul 24
DSM3:24 pmDes Moines
4h 39m
1 stop
ROA9:03 pmRoanoke
Jul 30
ROA6:40 amRoanoke
4h 37m
1 stop
DSM10:17 amDes Moines
$369
United Airlines
Oct 24
DSM1:35 pmDes Moines
9h 08m
2 stops
ROA11:43 pmRoanoke
Oct 28
ROA7:00 amRoanoke
6h 30m
1 stop
DSM12:30 pmDes Moines
$394
United Airlines
Oct 24
DSM3:11 pmDes Moines
7h 32m
2 stops
ROA11:43 pmRoanoke
Oct 28
ROA11:00 amRoanoke
10h 32m
2 stops
DSM8:32 pmDes Moines
$399

Delta flights from Des Moines to Roanoke

Our best Delta deals on Des Moines to Roanoke flight tickets
Delta
Jun 6
DSM4:00 pmDes Moines
5h 58m
1 stop
ROA10:58 pmRoanoke
Jun 10
ROA6:00 amRoanoke
5h 43m
1 stop
DSM10:43 amDes Moines
$339
Delta
Jul 2
DSM5:00 pmDes Moines
6h 32m
1 stop
ROA12:32 amRoanoke
Jul 5
ROA6:00 amRoanoke
5h 45m
1 stop
DSM10:45 amDes Moines
$354
Delta
Jun 10
DSM6:08 amDes Moines
7h 40m
2 stops
ROA2:48 pmRoanoke
Jun 14
ROA6:00 amRoanoke
5h 43m
1 stop
DSM10:43 amDes Moines
$688

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Roanoke that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 27, 2026.
Use the filters below to find and compare flights from Des Moines to Roanoke that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Sat 6/6

4:00 pm-10:58 pm

1 stop5h 58m

Roanoke

Wed 6/10

6:00 am-10:43 am

1 stop5h 43m

$339

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Thu 7/2

5:00 pm-12:32 am

1 stop6h 32m

Roanoke

Sun 7/5

6:00 am-10:45 am

1 stop5h 45m

$354
Quickest round-trip

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Fri 7/24

3:24 pm-9:03 pm

1 stop4h 39m

Roanoke

Thu 7/30

6:40 am-10:17 am

1 stop4h 37m

$369

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Thu 7/2

1:41 pm-9:20 pm

1 stop6h 39m

Roanoke

Sun 7/5

5:46 pm-10:45 pm

1 stop5h 59m

$379

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Sat 10/24

1:35 pm-11:43 pm

2 stops9h 08m

Roanoke

Wed 10/28

7:00 am-12:30 pm

1 stop6h 30m

$394

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Sat 10/24

3:11 pm-11:43 pm

2 stops7h 32m

Roanoke

Wed 10/28

11:00 am-8:32 pm

2 stops10h 32m

$399

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Fri 7/24

11:23 am-11:44 pm

2 stops11h 21m

Roanoke

Thu 7/30

6:40 am-10:17 am

1 stop4h 37m

$404

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Sat 10/24

3:11 pm-10:59 pm

1 stop6h 48m

Roanoke

Wed 10/28

5:38 pm-11:01 pm

1 stop6h 23m

$410

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Sat 6/6

5:00 am-1:51 pm

2 stops7h 51m

Roanoke

Wed 6/10

6:02 pm-12:12 am

1 stop7h 10m

$431

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Wed 6/10

1:33 pm-7:49 pm

1 stop5h 16m

Roanoke

Sun 6/14

7:58 pm-12:12 am

1 stop5h 14m

$434

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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See travel insights to Roanoke from

How to get the cheapest flight ticket from Des Moines to Roanoke

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Roanoke?

What is the cheapest month to fly to Roanoke?

The month of December is, on average, the cheapest month to fly to Roanoke from Des Moines, with most prices found around $0. If you aren’t able to travel to Roanoke during the month of December, then flying in March is also cheap. Prices for this month can be found on momondo for an average of $0.

When to book flights from Des Moines to Roanoke

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Roanoke according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Roanoke (DSM to ROA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Roanoke

Fastest flight time

4h 53m

Direct flights

None
The fastest flight from Des Moines to Roanoke takes 4h 53m
There are no direct flights from Des Moines to Roanoke. There are no popular flight routes from Des Moines to Roanoke.
Search flight deals

Frequently asked questions about flying from Des Moines to Roanoke

  • How far is Des Moines to Roanoke by plane?

    The distance between Des Moines and Roanoke is about 787.3 mi. Typically, this will take 4h 53m by plane in normal conditions.

  • When did momondo last update prices for flights from Des Moines Airport to Roanoke Airport?

    Prices for flights from Des Moines Airport to Roanoke Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Roanoke Airport?

  • How old do you have to be to fly from Des Moines Airport to Roanoke Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Roanoke Airport.

  • What documentation or ID do you need to fly to Roanoke Airport?

    The necessary travel and health documents for your Roanoke Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Roanoke?

Best airlines flying from Des Moines to Roanoke

Compare and see reviews for airlines that fly from Des Moines to Roanoke with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $258Free CancellationRating
7.1
11,639 reviews
Search American Airlines flights

Traveling to a place near Roanoke?

Book flights to Roanoke if you plan to visit one of these locations
Blacksburg
Christiansburg
Salem
Radford
Rocky Mount

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Roanoke?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Roanoke. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Roanoke with flexible booking policies on momondo?

Flights from Des Moines to Roanoke with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Roanoke?

momondo helps you find the best flight between Des Moines and Roanoke by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Roanoke right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Roanoke, momondo offers a useful price alert feature which will track prices for flights to Roanoke from Des Moines and alert you when they change.

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