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Cheap flights from Des Moines to Roanoke from $269

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Roanoke departing on 9/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Roanoke

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
1:41 pm - 9:20 pm
DSM
-
ROA
6h 39m
1 stop
American Airlines Logo
5:35 pm - 12:20 am
ROA
-
DSM
7h 45m
1 stop
$309American Airlines
Tue, Aug 4 - Tue, Aug 11
American Airlines Logo
5:00 am - 4:14 pm
DSM
-
ROA
10h 14m
2 stops
American Airlines Logo
12:33 pm - 6:41 pm
ROA
-
DSM
7h 08m
1 stop
$314American Airlines
Tue, Aug 4 - Tue, Aug 11
American Airlines Logo
5:00 am - 4:14 pm
DSM
-
ROA
10h 14m
2 stops
American Airlines Logo
5:07 pm - 12:20 am
ROA
-
DSM
8h 13m
2 stops
$319American Airlines
Tue, Aug 4 - Tue, Aug 11
United Airlines Logo
6:00 am - 2:18 pm
DSM
-
ROA
7h 18m
2 stops
United Airlines Logo
10:44 am - 2:20 pm
ROA
-
DSM
4h 36m
1 stop
$327United Airlines
Thu, Sep 3 - Tue, Sep 8
United Airlines Logo
6:00 am - 2:18 pm
DSM
-
ROA
7h 18m
2 stops
United Airlines Logo
10:26 am - 5:28 pm
ROA
-
DSM
8h 02m
2 stops
$332United Airlines
Thu, Sep 3 - Tue, Sep 8
United Airlines Logo
3:22 pm - 11:06 pm
DSM
-
ROA
6h 44m
1 stop
United Airlines Logo
10:44 am - 2:20 pm
ROA
-
DSM
4h 36m
1 stop
$389United Airlines
Tue, Sep 8 - Sat, Sep 12
United Airlines Logo
3:22 pm - 11:43 pm
DSM
-
ROA
7h 21m
2 stops
United Airlines Logo
10:44 am - 2:20 pm
ROA
-
DSM
4h 36m
1 stop
$394United Airlines
Tue, Sep 8 - Sat, Sep 12
United Airlines Logo
3:22 pm - 11:43 pm
DSM
-
ROA
7h 21m
2 stops
United Airlines Logo
10:44 am - 8:26 pm
ROA
-
DSM
10h 42m
2 stops
$399United Airlines
Tue, Sep 8 - Sat, Sep 12
United Airlines Logo
1:21 pm - 8:59 pm
DSM
-
ROA
6h 38m
1 stop
United Airlines Logo
6:40 am - 10:26 am
ROA
-
DSM
4h 46m
1 stop
$419United Airlines
Sun, Aug 23 - Sun, Aug 30
United Airlines Logo
1:21 pm - 8:59 pm
DSM
-
ROA
6h 38m
1 stop
United Airlines Logo
6:15 am - 2:16 pm
ROA
-
DSM
9h 01m
2 stops
$424United Airlines
Sun, Aug 23 - Sun, Aug 30

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United Airlines flights from Des Moines to Roanoke

Our best United Airlines deals on Des Moines to Roanoke flight tickets
United Airlines
Sep 3
DSM6:00 amDes Moines
7h 18m
2 stops
ROA2:18 pmRoanoke
Sep 8
ROA10:44 amRoanoke
4h 36m
1 stop
DSM2:20 pmDes Moines
$327
United Airlines
Sep 3
DSM6:00 amDes Moines
7h 18m
2 stops
ROA2:18 pmRoanoke
Sep 8
ROA10:26 amRoanoke
8h 02m
2 stops
DSM5:28 pmDes Moines
$332
United Airlines
Sep 8
DSM3:22 pmDes Moines
6h 44m
1 stop
ROA11:06 pmRoanoke
Sep 12
ROA10:44 amRoanoke
4h 36m
1 stop
DSM2:20 pmDes Moines
$389

American Airlines flights from Des Moines to Roanoke

Our best American Airlines deals on Des Moines to Roanoke flight tickets
American Airlines
Aug 4
DSM1:41 pmDes Moines
6h 39m
1 stop
ROA9:20 pmRoanoke
Aug 11
ROA5:35 pmRoanoke
7h 45m
1 stop
DSM12:20 amDes Moines
$309
American Airlines
Aug 4
DSM5:00 amDes Moines
10h 14m
2 stops
ROA4:14 pmRoanoke
Aug 11
ROA12:33 pmRoanoke
7h 08m
1 stop
DSM6:41 pmDes Moines
$314
American Airlines
Aug 4
DSM5:00 amDes Moines
10h 14m
2 stops
ROA4:14 pmRoanoke
Aug 11
ROA5:07 pmRoanoke
8h 13m
2 stops
DSM12:20 amDes Moines
$319

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Roanoke that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 13, 2026.
Use the filters below to find and compare flights from Des Moines to Roanoke that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Tue 8/4

1:41 pm-9:20 pm

1 stop6h 39m

Roanoke

Tue 8/11

5:35 pm-12:20 am

1 stop7h 45m

$309

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Tue 8/4

5:00 am-4:14 pm

2 stops10h 14m

Roanoke

Tue 8/11

12:33 pm-6:41 pm

1 stop7h 08m

$314

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Tue 8/4

5:00 am-4:14 pm

2 stops10h 14m

Roanoke

Tue 8/11

5:07 pm-12:20 am

2 stops8h 13m

$319

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Thu 9/3

6:00 am-2:18 pm

2 stops7h 18m

Roanoke

Tue 9/8

10:44 am-2:20 pm

1 stop4h 36m

$327

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Thu 9/3

6:00 am-2:18 pm

2 stops7h 18m

Roanoke

Tue 9/8

10:26 am-5:28 pm

2 stops8h 02m

$332
Quickest round-trip

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Tue 9/8

3:22 pm-11:06 pm

1 stop6h 44m

Roanoke

Sat 9/12

10:44 am-2:20 pm

1 stop4h 36m

$389

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Tue 9/8

3:22 pm-11:43 pm

2 stops7h 21m

Roanoke

Sat 9/12

10:44 am-2:20 pm

1 stop4h 36m

$394

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Tue 9/8

3:22 pm-11:43 pm

2 stops7h 21m

Roanoke

Sat 9/12

10:44 am-8:26 pm

2 stops10h 42m

$399

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Sun 8/23

1:21 pm-8:59 pm

1 stop6h 38m

Roanoke

Sun 8/30

6:40 am-10:26 am

1 stop4h 46m

$419

Des MoinesRoanoke

DSM - ROA

DSMROA

Des Moines

Sun 8/23

1:21 pm-8:59 pm

1 stop6h 38m

Roanoke

Sun 8/30

6:15 am-2:16 pm

2 stops9h 01m

$424

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
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See travel insights to Roanoke from

How to get the cheapest flight ticket from Des Moines to Roanoke

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Roanoke?

The month of December is, on average, the cheapest month to fly to Roanoke from Des Moines, with most prices found around $0. If you aren’t able to travel to Roanoke during the month of December, then flying in March is also cheap. Prices for this month can be found on momondo for an average of $0.

When to book flights from Des Moines to Roanoke

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Roanoke according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Roanoke (DSM to ROA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Roanoke

Fastest flight time

7h 18m

Direct flights

None
The fastest flight from Des Moines to Roanoke takes 7h 18m
There are no direct flights from Des Moines to Roanoke. There are no popular flight routes from Des Moines to Roanoke.
Search flight deals

Frequently asked questions about flying from Des Moines to Roanoke

  • How far is Des Moines to Roanoke by plane?

    The distance between Des Moines and Roanoke is about 787.3 mi. Typically, this will take 7h 18m by plane in normal conditions.

  • When did momondo last update prices for flights from Des Moines Airport to Roanoke Airport?

    Prices for flights from Des Moines Airport to Roanoke Airport are updated daily.

  • How many operators does momondo search for flights from Des Moines Airport to Roanoke Airport?

  • How old do you have to be to fly from Des Moines Airport to Roanoke Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Des Moines Airport to Roanoke Airport.

  • What documentation or ID do you need to fly to Roanoke Airport?

    The necessary travel and health documents for your Roanoke Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Roanoke?

Best airlines flying from Des Moines to Roanoke

Compare and see reviews for airlines that fly from Des Moines to Roanoke with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $258Free CancellationRating
7.1
11,810 reviews
Search American Airlines flights

Traveling to a place near Roanoke?

Book flights to Roanoke if you plan to visit one of these locations
Blacksburg
Christiansburg
Salem
Radford
Rocky Mount
Lafayette

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Roanoke?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Roanoke. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Roanoke with flexible booking policies on momondo?

Flights from Des Moines to Roanoke with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Des Moines to Roanoke?

momondo helps you find the best flight between Des Moines and Roanoke by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Roanoke right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Roanoke, momondo offers a useful price alert feature which will track prices for flights to Roanoke from Des Moines and alert you when they change.

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