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Cheap flights from Des Moines to Myrtle Beach from $169

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Myrtle Beach departing on 6/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Myrtle Beach

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:39 pm - 11:59 pm
DSM
-
MYR
4h 20m
1 stop
Delta Logo
6:00 am - 10:43 am
MYR
-
DSM
5h 43m
1 stop
$335Delta
Tue, Jun 9 - Tue, Jun 16
American Airlines Logo
1:37 pm - 9:46 pm
DSM
-
MYR
7h 09m
1 stop
American Airlines Logo
6:06 pm - 12:35 am
MYR
-
DSM
7h 29m
2 stops
$340American Airlines
Tue, Jun 9 - Tue, Jun 16
Multiple Airlines Logo
4:40 pm - 8:11 pm
DSM
-
MYR
26h 31m
1 stop
Multiple Airlines Logo
7:00 am - 1:50 pm
MYR
-
DSM
7h 50m
1 stop
$343Multiple Airlines
Fri, Jul 17 - Fri, Jul 24
American Airlines Logo
7:10 am - 5:26 pm
DSM
-
MYR
9h 16m
2 stops
American Airlines Logo
4:17 pm - 12:35 am
MYR
-
DSM
9h 18m
2 stops
$345American Airlines
Tue, Jun 9 - Tue, Jun 16
American Airlines Logo
1:51 pm - 9:47 pm
DSM
-
MYR
6h 56m
2 stops
American Airlines Logo
6:21 pm - 11:50 pm
MYR
-
DSM
6h 29m
1 stop
$350American Airlines
Tue, Jun 2 - Mon, Jun 8
Multiple Airlines Logo
4:40 pm - 8:11 pm
DSM
-
MYR
26h 31m
1 stop
Multiple Airlines Logo
4:51 pm - 2:30 pm
MYR
-
DSM
22h 39m
2 stops
$351Multiple Airlines
Fri, Jul 17 - Fri, Jul 24
Delta Logo
6:41 pm - 11:58 pm
DSM
-
MYR
4h 17m
1 stop
Delta Logo
4:07 pm - 10:32 pm
MYR
-
DSM
7h 25m
1 stop
$355Delta
Mon, May 25 - Thu, May 28
American Airlines Logo
5:00 am - 11:48 am
DSM
-
MYR
5h 48m
1 stop
American Airlines Logo
6:50 am - 1:18 pm
MYR
-
DSM
7h 28m
2 stops
$360American Airlines
Mon, May 25 - Thu, May 28
American Airlines Logo
6:33 am - 5:26 pm
DSM
-
MYR
9h 53m
2 stops
American Airlines Logo
6:06 pm - 12:08 am
MYR
-
DSM
7h 02m
2 stops
$366American Airlines
Mon, May 25 - Thu, May 28
Delta Logo
6:39 pm - 11:59 pm
DSM
-
MYR
4h 20m
1 stop
Delta Logo
7:00 am - 10:49 am
MYR
-
DSM
4h 49m
1 stop
$371Delta
Wed, Jun 10 - Sat, Jun 13

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Southwest flights from Des Moines to Myrtle Beach

Our best Southwest deals on Des Moines to Myrtle Beach flight tickets
Southwest
Jun 5
DSM1:30 pmDes Moines
6h 00m
1 stop
MYR8:30 pmMyrtle Beach Intl
Jun 6
MYR2:00 pmMyrtle Beach Intl
9h 50m
2 stops
DSM10:50 pmDes Moines
$386
Southwest
Jun 3
DSM5:30 amDes Moines
11h 05m
2 stops
MYR5:35 pmMyrtle Beach Intl
Jun 9
MYR10:25 amMyrtle Beach Intl
12h 15m
2 stops
DSM9:40 pmDes Moines
$387
Southwest
Jun 1
DSM5:25 amDes Moines
8h 45m
2 stops
MYR3:10 pmMyrtle Beach Intl
Jun 4
MYR11:55 amMyrtle Beach Intl
11h 25m
2 stops
DSM10:20 pmDes Moines
$421

United Airlines flights from Des Moines to Myrtle Beach

Our best United Airlines deals on Des Moines to Myrtle Beach flight tickets
United Airlines
May 20
DSM6:15 amDes Moines
7h 03m
1 stop
MYR2:18 pmMyrtle Beach Intl
May 30
MYR10:34 amMyrtle Beach Intl
9h 51m
2 stops
DSM7:25 pmDes Moines
$426
United Airlines
May 18
DSM8:00 amDes Moines
5h 18m
1 stop
MYR2:18 pmMyrtle Beach Intl
May 22
MYR10:34 amMyrtle Beach Intl
9h 51m
2 stops
DSM7:25 pmDes Moines
$718
United Airlines
May 13
DSM8:00 amDes Moines
5h 18m
1 stop
MYR2:18 pmMyrtle Beach Intl
May 16
MYR3:14 pmMyrtle Beach Intl
9h 30m
2 stops
DSM11:44 pmDes Moines
$752

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Myrtle Beach that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 4, 2026.
Use the filters below to find and compare flights from Des Moines to Myrtle Beach that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Tue 6/9

6:39 pm-11:59 pm

1 stop4h 20m

Myrtle Beach Intl

Tue 6/16

6:00 am-10:43 am

1 stop5h 43m

$335

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Tue 6/9

1:37 pm-9:46 pm

1 stop7h 09m

Myrtle Beach Intl

Tue 6/16

6:06 pm-12:35 am

2 stops7h 29m

$340

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Fri 7/17

4:40 pm-8:11 pm

1 stop26h 31m

Myrtle Beach Intl

Fri 7/24

7:00 am-1:50 pm

1 stop7h 50m

$343

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Tue 6/9

7:10 am-5:26 pm

2 stops9h 16m

Myrtle Beach Intl

Tue 6/16

4:17 pm-12:35 am

2 stops9h 18m

$345

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Tue 6/2

1:51 pm-9:47 pm

2 stops6h 56m

Myrtle Beach Intl

Mon 6/8

6:21 pm-11:50 pm

1 stop6h 29m

$350

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Fri 7/17

4:40 pm-8:11 pm

1 stop26h 31m

Myrtle Beach Intl

Fri 7/24

4:51 pm-2:30 pm

2 stops22h 39m

$351

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Mon 5/25

6:41 pm-11:58 pm

1 stop4h 17m

Myrtle Beach Intl

Thu 5/28

4:07 pm-10:32 pm

1 stop7h 25m

$355

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Mon 5/25

5:00 am-11:48 am

1 stop5h 48m

Myrtle Beach Intl

Thu 5/28

6:50 am-1:18 pm

2 stops7h 28m

$360

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Mon 5/25

6:33 am-5:26 pm

2 stops9h 53m

Myrtle Beach Intl

Thu 5/28

6:06 pm-12:08 am

2 stops7h 02m

$366
Quickest round-trip

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Wed 6/10

6:39 pm-11:59 pm

1 stop4h 20m

Myrtle Beach Intl

Sat 6/13

7:00 am-10:49 am

1 stop4h 49m

$371

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Myrtle Beach from

How to get the cheapest flight ticket from Des Moines to Myrtle Beach

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Myrtle Beach?

What is the cheapest month to fly to Myrtle Beach?

In general, January is the cheapest month to fly from Des Moines to Myrtle Beach. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $291. If you are unable to visit Myrtle Beach during the month of January, then departing from Des Moines during the month August is also very affordable. Most momondo users find prices during this month for around $306.

Can stopping save me money on Des Moines to Myrtle Beach flights?

You could potentially save up to 27% on your flight if you consider stops on a Des Moines to Myrtle Beach flight.

When to book flights from Des Moines to Myrtle Beach

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Myrtle Beach according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Myrtle Beach (DSM to MYR) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Myrtle Beach

Fastest flight time

4h 09m

Direct flights

None
The fastest flight from Des Moines to Myrtle Beach takes 4h 09m
There are no direct flights from Des Moines to Myrtle Beach. There are no popular flight routes from Des Moines to Myrtle Beach.
Search flight deals

Frequently asked questions about flying from Des Moines to Myrtle Beach

  • How far is Des Moines to Myrtle Beach Intl by plane?

    A flight from Des Moines to Myrtle Beach Intl will travel around 970.9 mi. Flights usually cover this in 4h 09m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Myrtle Beach Intl Airport?

    Prices for flights from Des Moines Airport to Myrtle Beach Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Des Moines Airport to Myrtle Beach Intl Airport?

  • How old do you have to be to fly from Des Moines Airport to Myrtle Beach Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Myrtle Beach Intl Airport.

  • What documentation or ID do you need to fly to Myrtle Beach Intl Airport?

    The travel and health documents you'll need for your trip to Myrtle Beach Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Myrtle Beach Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Myrtle Beach?

Best airlines flying from Des Moines to Myrtle Beach

Compare and see reviews for airlines that fly from Des Moines to Myrtle Beach with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,671 reviews
Search American Airlines flights
SouthwestPriceFrom $272Free CancellationRating
7.9
4,307 reviews
Search Southwest flights
DeltaPriceFrom $302Free CancellationRating
7.9
8,460 reviews
Search Delta flights

Traveling to a place near Myrtle Beach?

Book flights to Myrtle Beach if you plan to visit one of these locations
North Myrtle Beach
Pawleys Island
Ocean Isle Beach
Sunset Beach
Murrells Inlet
Garden City Beach
Surfside Beach
Conway
Little River
Georgetown

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Myrtle Beach?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Myrtle Beach. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Myrtle Beach with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Myrtle Beach from Des Moines with this policy.

How can momondo help me find flights from Des Moines to Myrtle Beach?

Once all potential Des Moines to Myrtle Beach flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to Myrtle Beach right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Myrtle Beach from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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