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Cheap flights from Des Moines to Myrtle Beach from $171

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Myrtle Beach departing on 9/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Myrtle Beach

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
1:30 pm - 9:08 pmDSM  Des Moines-MYR Myrtle Beach Intl
6h 38m1 stop Charlotte Douglas
American Airlines Logo
7:19 pm - 11:41 pmMYR  Myrtle Beach Intl-DSM Des Moines
5h 22m1 stop Washington, D.C. Reagan-National
$269American Airlines
Thu, Sep 10 - Mon, Sep 14
American Airlines Logo
1:30 pm - 9:08 pmDSM  Des Moines-MYR Myrtle Beach Intl
6h 38m1 stop Charlotte Douglas
American Airlines Logo
6:30 am - 10:42 amMYR  Myrtle Beach Intl-DSM Des Moines
5h 12m1 stop Charlotte Douglas
$269American Airlines
Wed, Sep 30 - Wed, Oct 7
American Airlines Logo
11:09 am - 4:23 pmDSM  Des Moines-MYR Myrtle Beach Intl
4h 14m1 stop Charlotte Douglas
American Airlines Logo
6:12 am - 10:10 amMYR  Myrtle Beach Intl-DSM Des Moines
4h 58m1 stop Charlotte Douglas
$269American Airlines
Sat, Nov 7 - Sat, Nov 14
Southwest Logo
5:20 am - 7:30 pmDSM  Des Moines-MYR Myrtle Beach Intl
13h 10m2 stops Chicago Midway Baltimore/Washington
Southwest Logo
10:35 am - 8:35 pmMYR  Myrtle Beach Intl-DSM Des Moines
11h 00m2 stops Nashville Intl Denver Intl
$285Southwest
Sat, Nov 7 - Sat, Nov 14
Southwest Logo
6:00 am - 6:25 pmDSM  Des Moines-MYR Myrtle Beach Intl
11h 25m2 stops Chicago Midway Baltimore/Washington
Southwest Logo
10:35 am - 7:40 pmMYR  Myrtle Beach Intl-DSM Des Moines
10h 05m2 stops Nashville Intl Chicago Midway
$285Southwest
Tue, Nov 10 - Sat, Nov 14
Southwest Logo
5:55 am - 5:25 pmDSM  Des Moines-MYR Myrtle Beach Intl
10h 30m2 stops Chicago Midway Baltimore/Washington
Southwest Logo
8:00 am - 9:35 pmMYR  Myrtle Beach Intl-DSM Des Moines
14h 35m2 stops Baltimore/Washington Chicago Midway
$292Southwest
Wed, Jan 6 - Wed, Jan 13
Multiple Airlines Logo
12:45 pm - 8:50 amDSM  Des Moines-MYR Myrtle Beach Intl
19h 05m1 stop Orlando Sanford Intl
Multiple Airlines Logo
8:35 am - 1:59 pmMYR  Myrtle Beach Intl-DSM Des Moines
6h 24m1 stop Philadelphia
$315Multiple Airlines
Wed, Oct 28 - Sun, Nov 1
Multiple Airlines Logo
12:45 pm - 2:39 pmDSM  Des Moines-MYR Myrtle Beach Intl
24h 54m2 stops Orlando Sanford Intl Allentown-Bethlehem
Multiple Airlines Logo
8:35 am - 1:59 pmMYR  Myrtle Beach Intl-DSM Des Moines
6h 24m1 stop Philadelphia
$341Multiple Airlines
Wed, Oct 28 - Sun, Nov 1
Delta Logo
11:04 am - 5:55 pmDSM  Des Moines-MYR Myrtle Beach Intl
5h 51m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:45 pm - 10:29 pmMYR  Myrtle Beach Intl-DSM Des Moines
4h 44m1 stop Atlanta Hartsfield-Jackson
$417Delta
Sat, Jan 9 - Mon, Jan 11
Delta Logo
5:15 pm - 11:35 pmDSM  Des Moines-MYR Myrtle Beach Intl
5h 20m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:45 pm - 10:29 pmMYR  Myrtle Beach Intl-DSM Des Moines
4h 44m1 stop Atlanta Hartsfield-Jackson
$417Delta
Wed, Jan 6 - Mon, Jan 11

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Delta flights from Des Moines to Myrtle Beach

Our best Delta deals on Des Moines to Myrtle Beach flight tickets
Delta
Jan 4
DSM5:15 pmDes Moines
5h 20m
1 stop
MYR11:35 pmMyrtle Beach Intl
Jan 13
MYR10:55 amMyrtle Beach Intl
6h 32m
1 stop
DSM4:27 pmDes Moines
$417
Delta
Jan 1
DSM6:30 pmDes Moines
14h 38m
1 stop
MYR10:08 amMyrtle Beach Intl
Jan 13
MYR10:55 amMyrtle Beach Intl
6h 32m
1 stop
DSM4:27 pmDes Moines
$502
Delta
Jan 1
DSM6:30 pmDes Moines
22h 25m
1 stop
MYR5:55 pmMyrtle Beach Intl
Jan 15
MYR6:00 amMyrtle Beach Intl
5h 18m
1 stop
DSM10:18 amDes Moines
$512

United Airlines flights from Des Moines to Myrtle Beach

Our best United Airlines deals on Des Moines to Myrtle Beach flight tickets
United Airlines
Dec 3
DSM8:00 amDes Moines
5h 33m
1 stop
MYR2:33 pmMyrtle Beach Intl
Dec 6
MYR3:20 pmMyrtle Beach Intl
6h 57m
1 stop
DSM9:17 pmDes Moines
$497
United Airlines
Jan 7
DSM6:15 amDes Moines
9h 34m
2 stops
MYR4:49 pmMyrtle Beach Intl
Jan 11
MYR11:25 amMyrtle Beach Intl
10h 07m
2 stops
DSM8:32 pmDes Moines
$507
United Airlines
Aug 25
DSM1:21 pmDes Moines
19h 23m
3 stops
MYR9:44 amMyrtle Beach Intl
Sep 8
MYR12:00 pmMyrtle Beach Intl
12h 33m
2 stops
DSM11:33 pmDes Moines
$750

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Myrtle Beach that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 12, 2026.
Use the filters below to find and compare flights from Des Moines to Myrtle Beach that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesMyrtle Beach

DSM Des Moines - MYR Myrtle Beach Intl

DSMMYR

Des Moines

Thu 9/10

1:30 pm-9:08 pm

1 stop6h 38m

Myrtle Beach Intl

Mon 9/14

7:19 pm-11:41 pm

1 stop5h 22m

$269

Des MoinesMyrtle Beach

DSM Des Moines - MYR Myrtle Beach Intl

DSMMYR

Des Moines

Wed 9/30

1:30 pm-9:08 pm

1 stop6h 38m

Myrtle Beach Intl

Wed 10/7

6:30 am-10:42 am

1 stop5h 12m

$269
Quickest round-trip

Des MoinesMyrtle Beach

DSM Des Moines - MYR Myrtle Beach Intl

DSMMYR

Des Moines

Sat 11/7

11:09 am-4:23 pm

1 stop4h 14m

Myrtle Beach Intl

Sat 11/14

6:12 am-10:10 am

1 stop4h 58m

$269

Des MoinesMyrtle Beach

DSM Des Moines - MYR Myrtle Beach Intl

DSMMYR

Des Moines

Sat 11/7

5:20 am-7:30 pm

2 stops13h 10m

Myrtle Beach Intl

Sat 11/14

10:35 am-8:35 pm

2 stops11h 00m

$285

Des MoinesMyrtle Beach

DSM Des Moines - MYR Myrtle Beach Intl

DSMMYR

Des Moines

Tue 11/10

6:00 am-6:25 pm

2 stops11h 25m

Myrtle Beach Intl

Sat 11/14

10:35 am-7:40 pm

2 stops10h 05m

$285

Des MoinesMyrtle Beach

DSM Des Moines - MYR Myrtle Beach Intl

DSMMYR

Des Moines

Wed 1/6

5:55 am-5:25 pm

2 stops10h 30m

Myrtle Beach Intl

Wed 1/13

8:00 am-9:35 pm

2 stops14h 35m

$292

Des MoinesMyrtle Beach

DSM Des Moines - MYR Myrtle Beach Intl

DSMMYR

Des Moines

Wed 10/28

12:45 pm-8:50 am

1 stop19h 05m

Myrtle Beach Intl

Sun 11/1

8:35 am-1:59 pm

1 stop6h 24m

$315

Des MoinesMyrtle Beach

DSM Des Moines - MYR Myrtle Beach Intl

DSMMYR

Des Moines

Wed 10/28

12:45 pm-2:39 pm

2 stops24h 54m

Myrtle Beach Intl

Sun 11/1

8:35 am-1:59 pm

1 stop6h 24m

$341

Des MoinesMyrtle Beach

DSM Des Moines - MYR Myrtle Beach Intl

DSMMYR

Des Moines

Sat 1/9

11:04 am-5:55 pm

1 stop5h 51m

Myrtle Beach Intl

Mon 1/11

6:45 pm-10:29 pm

1 stop4h 44m

$417

Des MoinesMyrtle Beach

DSM Des Moines - MYR Myrtle Beach Intl

DSMMYR

Des Moines

Wed 1/6

5:15 pm-11:35 pm

1 stop5h 20m

Myrtle Beach Intl

Mon 1/11

6:45 pm-10:29 pm

1 stop4h 44m

$417

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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See travel insights to Myrtle Beach from

How to get the cheapest flight ticket from Des Moines to Myrtle Beach

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Myrtle Beach?

Prices are currently low for flights on this route.

Typical prices usually range from $386 to $518.
The lowest price recently found on this route was $269.

What is the cheapest month to fly to Myrtle Beach?

In general, January is the cheapest month to fly from Des Moines to Myrtle Beach. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $293. If you are unable to visit Myrtle Beach during the month of January, then departing from Des Moines during the month September is also very affordable. Most momondo users find prices during this month for around $316.

Can stopping save me money on Des Moines to Myrtle Beach flights?

You could potentially save up to 47% on your flight if you consider stops on a Des Moines to Myrtle Beach flight.

When to book flights from Des Moines to Myrtle Beach

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Myrtle Beach according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Myrtle Beach (DSM to MYR) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Myrtle Beach

Fastest flight time

4h 05m

Direct flights

None
The fastest flight from Des Moines to Myrtle Beach takes 4h 05m
There are no direct flights from Des Moines to Myrtle Beach. There are no popular flight routes from Des Moines to Myrtle Beach.
Search flight deals

Frequently asked questions about flying from Des Moines to Myrtle Beach

  • How far is Des Moines to Myrtle Beach Intl by plane?

    A flight from Des Moines to Myrtle Beach Intl will travel around 970.9 mi. Flights usually cover this in 4h 05m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Myrtle Beach Intl Airport?

    Prices for flights from Des Moines Airport to Myrtle Beach Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Des Moines Airport to Myrtle Beach Intl Airport?

  • How old do you have to be to fly from Des Moines Airport to Myrtle Beach Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Myrtle Beach Intl Airport.

  • What documentation or ID do you need to fly to Myrtle Beach Intl Airport?

    The travel and health documents you'll need for your trip to Myrtle Beach Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Myrtle Beach Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Myrtle Beach?

Best airlines flying from Des Moines to Myrtle Beach

Compare and see reviews for airlines that fly from Des Moines to Myrtle Beach with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $158Free CancellationRating
7.8
8,505 reviews
Search Delta flights
American AirlinesPriceFrom $288Free CancellationRating
7.1
11,915 reviews
Search American Airlines flights
SouthwestPriceFrom $344Free CancellationRating
8.0
4,218 reviews
Search Southwest flights

Traveling to a place near Myrtle Beach?

Book flights to Myrtle Beach if you plan to visit one of these locations
North Myrtle Beach
Pawleys Island
Surfside Beach
Conway
Ocean Isle Beach
Murrells Inlet
Sunset Beach
Garden City Beach
Georgetown
Little River

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Myrtle Beach?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Myrtle Beach. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Myrtle Beach with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Myrtle Beach from Des Moines with this policy.

How can momondo help me find flights from Des Moines to Myrtle Beach?

Once all potential Des Moines to Myrtle Beach flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to Myrtle Beach right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Myrtle Beach from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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