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Cheap flights from Des Moines to Myrtle Beach from $159

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Myrtle Beach departing on 12/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

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Multiple Airlines Logo
3:34 pm - 10:41 amDSM-MYR
18h 07m2 stops
Multiple Airlines Logo
11:46 am - 10:46 pmMYR-DSM
12h 00m1 stop
$295Multiple Airlines
Find Deal
Mon, Feb 2 - Thu, Feb 5
Multiple Airlines Logo
11:09 am - 10:41 amDSM-MYR
22h 32m3 stops
Multiple Airlines Logo
11:46 am - 10:46 pmMYR-DSM
12h 00m1 stop
$311Multiple Airlines
Find Deal
Mon, Feb 2 - Thu, Feb 5
Delta Logo
5:16 pm - 11:43 pmDSM-MYR
5h 27m1 stop
Delta Logo
12:25 pm - 7:34 pmMYR-DSM
8h 09m1 stop
$313Delta
Find Deal
Mon, Feb 2 - Thu, Feb 5
Delta Logo
5:15 pm - 11:35 pmDSM-MYR
5h 20m1 stop
Delta Logo
1:00 pm - 4:56 pmMYR-DSM
4h 56m1 stop
$387Delta
Find Deal
Mon, Mar 9 - Thu, Mar 12
American Airlines Logo
2:15 pm - 10:05 pmDSM-MYR
6h 50m1 stop
American Airlines Logo
8:07 pm - 12:21 amMYR-DSM
5h 14m1 stop
$397American Airlines
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Wed, Nov 26 - Mon, Dec 1
Southwest Logo
5:35 am - 7:30 pmDSM-MYR
12h 55m2 stops
Southwest Logo
10:35 am - 10:20 pmMYR-DSM
12h 45m2 stops
$448Southwest
Find Deal
Thu, Mar 5 - Thu, Mar 12
American Airlines Logo
7:29 am - 5:10 pmDSM-MYR
8h 41m2 stops
American Airlines Logo
5:37 pm - 10:32 pmMYR-DSM
5h 55m1 stop
$462American Airlines
Find Deal
Mon, Mar 9 - Thu, Mar 12
Southwest Logo
8:00 am - 7:30 pmDSM-MYR
10h 30m2 stops
Southwest Logo
8:00 am - 7:55 pmMYR-DSM
12h 55m2 stops
$618Southwest
Find Deal
Mon, Nov 10 - Wed, Nov 12
United Airlines Logo
3:15 pm - 2:57 pmDSM-MYR
22h 42m3 stops
United Airlines Logo
3:53 pm - 4:12 pmMYR-DSM
25h 19m2 stops
$1,072United Airlines
Find Deal
Mon, Nov 10 - Wed, Nov 12
United Airlines Logo
8:00 am - 12:12 pmDSM-MYR
27h 12m3 stops
United Airlines Logo
6:04 pm - 9:50 pmMYR-DSM
28h 46m2 stops
$1,145United Airlines
Find Deal
Thu, Mar 5 - Thu, Mar 12

American Airlines flights from Des Moines to Myrtle Beach

Our best American Airlines deals on Des Moines to Myrtle Beach flight tickets
American Airlines
Nov 26
DSM2:15 pmDes Moines
6h 50m
1 stop
MYR10:05 pmMyrtle Beach Intl
Dec 1
MYR8:07 pmMyrtle Beach Intl
5h 14m
1 stop
DSM12:21 amDes Moines
$397
Find similar
American Airlines
Mar 9
DSM7:29 amDes Moines
8h 41m
2 stops
MYR5:10 pmMyrtle Beach Intl
Mar 12
MYR5:37 pmMyrtle Beach Intl
5h 55m
1 stop
DSM10:32 pmDes Moines
$462
Find similar
American Airlines
Mar 9
DSM7:29 amDes Moines
8h 41m
2 stops
MYR5:10 pmMyrtle Beach Intl
Mar 12
MYR7:17 amMyrtle Beach Intl
12h 54m
2 stops
DSM7:11 pmDes Moines
$477
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Delta flights from Des Moines to Myrtle Beach

Our best Delta deals on Des Moines to Myrtle Beach flight tickets
Delta
Feb 2
DSM5:16 pmDes Moines
5h 27m
1 stop
MYR11:43 pmMyrtle Beach Intl
Feb 5
MYR12:25 pmMyrtle Beach Intl
8h 09m
1 stop
DSM7:34 pmDes Moines
$313
Find similar
Delta
Mar 9
DSM5:15 pmDes Moines
5h 20m
1 stop
MYR11:35 pmMyrtle Beach Intl
Mar 12
MYR1:00 pmMyrtle Beach Intl
4h 56m
1 stop
DSM4:56 pmDes Moines
$387
Find similar
Delta
Nov 12
DSM11:28 amDes Moines
5h 27m
1 stop
MYR5:55 pmMyrtle Beach Intl
Nov 16
MYR6:00 amMyrtle Beach Intl
5h 42m
1 stop
DSM10:42 amDes Moines
$467
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momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Myrtle Beach that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Des Moines to Myrtle Beach that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Mon 2/2

3:34 pm-10:41 am

2 stops18h 07m

Myrtle Beach Intl

Thu 2/5

11:46 am-10:46 pm

1 stop12h 00m

$295

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Mon 2/2

11:09 am-10:41 am

3 stops22h 32m

Myrtle Beach Intl

Thu 2/5

11:46 am-10:46 pm

1 stop12h 00m

$311

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Mon 2/2

5:16 pm-11:43 pm

1 stop5h 27m

Myrtle Beach Intl

Thu 2/5

12:25 pm-7:34 pm

1 stop8h 09m

$313

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Mon 3/9

5:15 pm-11:35 pm

1 stop5h 20m

Myrtle Beach Intl

Thu 3/12

1:00 pm-4:56 pm

1 stop4h 56m

$387

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Wed 11/26

2:15 pm-10:05 pm

1 stop6h 50m

Myrtle Beach Intl

Mon 12/1

8:07 pm-12:21 am

1 stop5h 14m

$397

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Thu 3/5

5:35 am-7:30 pm

2 stops12h 55m

Myrtle Beach Intl

Thu 3/12

10:35 am-10:20 pm

2 stops12h 45m

$448

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Mon 3/9

7:29 am-5:10 pm

2 stops8h 41m

Myrtle Beach Intl

Thu 3/12

5:37 pm-10:32 pm

1 stop5h 55m

$462

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Mon 11/10

8:00 am-7:30 pm

2 stops10h 30m

Myrtle Beach Intl

Wed 11/12

8:00 am-7:55 pm

2 stops12h 55m

$618

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Mon 11/10

3:15 pm-2:57 pm

3 stops22h 42m

Myrtle Beach Intl

Wed 11/12

3:53 pm-4:12 pm

2 stops25h 19m

$1,072

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Thu 3/5

8:00 am-12:12 pm

3 stops27h 12m

Myrtle Beach Intl

Thu 3/12

6:04 pm-9:50 pm

2 stops28h 46m

$1,145

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Myrtle Beach from

How to get the cheapest flight ticket from Des Moines to Myrtle Beach

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Myrtle Beach?

In general, August is the cheapest month to fly from Des Moines to Myrtle Beach. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $296. If you are unable to visit Myrtle Beach during the month of August, then departing from Des Moines during the month April is also very affordable. Most momondo users find prices during this month for around $316.

What is the cheapest day to depart on your flight to Myrtle Beach?

Our data shows that Tuesday is the least expensive day to fly to Myrtle Beach. Tickets to fly out on this day can be as low as $340. The most expensive day to fly to Myrtle Beach is Thursday, with ticket prices averaging around $487.

What is the cheapest time of day to depart on your flight to Myrtle Beach?

The cheapest time of day to fly to Myrtle Beach is in the afternoon when flights can be purchased for as low as $364. Flights in the morning are often more expensive with an average ticket price of $402.

How far in advance should I book a flight to Myrtle Beach?

You are more likely to see cheaper flights to Myrtle Beach from Des Moines when booking weeks ahead of your departure date. In general, you can expect to find flights to Myrtle Beach for around $391 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Myrtle Beach from Des Moines for as low as $296 on momondo.

When to book flights from Des Moines to Myrtle Beach

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Myrtle Beach according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Myrtle Beach (DSM to MYR) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Myrtle Beach

Direct flights

None
There are no direct flights from Des Moines to Myrtle Beach. There are no popular flight routes from Des Moines to Myrtle Beach.
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  • How far is Des Moines to Myrtle Beach Intl by plane?

    A flight from Des Moines to Myrtle Beach Intl will travel around 970.9 mi. Flights usually cover this in 4h 04m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Myrtle Beach Intl Airport?

    Prices for flights from Des Moines Airport to Myrtle Beach Intl Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Des Moines Airport to Myrtle Beach Intl Airport?

  • How old do you have to be to fly from Des Moines Airport to Myrtle Beach Intl Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Myrtle Beach Intl Airport.

  • What documentation or ID do you need to fly to Myrtle Beach Intl Airport?

    The travel and health documents you'll need for your trip to Myrtle Beach Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Myrtle Beach Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Des Moines to Myrtle Beach?

Best airlines flying from Des Moines to Myrtle Beach

Compare and see reviews for airlines that fly from Des Moines to Myrtle Beach with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,035 reviews
Search American Airlines flights
SouthwestPriceFrom $272Free CancellationRating
8.0
4,243 reviews
Search Southwest flights
DeltaPriceFrom $292Free CancellationRating
7.9
7,998 reviews
Search Delta flights
United AirlinesPriceFrom $366Free CancellationRating
7.4
8,998 reviews
Search United Airlines flights

Traveling to a place near Myrtle Beach?

Book flights to Myrtle Beach if you plan to visit one of these locations
North Myrtle Beach
Pawleys Island
Sunset Beach
Ocean Isle Beach
Murrells Inlet
Garden City Beach
Surfside Beach
Conway
Little River
Georgetown

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Myrtle Beach?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Myrtle Beach. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Myrtle Beach with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Myrtle Beach from Des Moines with this policy.

How can momondo help me find flights from Des Moines to Myrtle Beach?

Once all potential Des Moines to Myrtle Beach flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to Myrtle Beach right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Myrtle Beach from Des Moines. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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