Cheap flights from Chicago to Greenville from $106

The month of April is another great option to travel to Greenville, with average flight prices from Chicago averaging around $262.

According to our data, Saturday is the cheapest day to fly to Greenville from Chicago. The lowest ticket price found for a Saturday departure recently was $269. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $374. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

Our most recent data shows that the best time of day to fly to Greenville is at noon. Flights from Chicago to Greenville during this time can be as low as $286. Flights to Greenville are more costly in the evening, with an average ticket price of $320. Departure times in the evening fall within the peak daily travel times, which is why tickets can be more expensive.

Fly from Chicago O'Hare Intl to Greenville for the best Chicago - Greenville flight prices

You are more likely to see cheaper flights to Greenville from Chicago when booking weeks ahead of your departure date. In general, you can expect to find flights to Greenville for around $298 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Greenville from Chicago for as low as $222 on momondo.

There are 4 cabin classes available to choose from on Chicago to Greenville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

No. A direct flight is the cheapest option for a flight between Chicago to Greenville.

As of March 2026, prices for Chicago to Greenville flights are approximately 9% cheaper when compared to flights at the same time last year.

Southwest and Delta are the most popular carriers operating from Chicago to Greenville

American Airlines, United Airlines and Frontier are the top three most popular airlines that fly to Greenville from Chicago according to our data. American Airlines is the first choice among our users, with 50% of people opting to fly with this airline when traveling to Greenville. Keep in mind that there are 7 different airlines that fly to Greenville on a routine basis, so you have a few additional options to choose from.

15 flights are operational daily from Chicago to Greenville as of March 2026. The most popular departure time for this route is 5:00PM, with 56% of flights per day taking off in the afternoon.

As of March 2026, 106 flights take off from Chicago and land in Greenville each week. The most common flight departure day for this route is Wed, with 20% of weekly flights taking off on this day.