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Cheap flights from Santa Ana, California to St. Louis from $69

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana, California to St. Louis departing on 1/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Santa Ana, California to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
2:20 pm - 9:07 amSNA-STL
16h 47m1 stop
Frontier Logo
2:42 pm - 6:48 pmSTL-SNA
6h 06m1 stop
$130Frontier
Find Deal
Sat, Nov 15 - Mon, Nov 17
Frontier Logo
11:15 am - 10:14 amSNA-STL
20h 59m1 stop
Frontier Logo
9:14 pm - 5:39 pmSTL-SNA
22h 25m1 stop
$134Frontier
Find Deal
Thu, Dec 4 - Sun, Dec 7
Frontier Logo
8:18 pm - 12:15 pmSNA-STL
13h 57m1 stop
Frontier Logo
1:07 pm - 7:24 pmSTL-SNA
8h 17m1 stop
$138Frontier
Find Deal
Thu, Jan 15 - Sun, Jan 18
Frontier Logo
8:16 pm - 8:12 pmSNA-STL
21h 56m1 stop
Frontier Logo
7:45 pm - 11:16 amSTL-SNA
17h 31m1 stop
$176Frontier
Find Deal
Thu, Nov 13 - Sat, Nov 15
Multiple Airlines Logo
6:34 pm - 12:12 pmSNA-STL
15h 38m1 stop
Multiple Airlines Logo
7:43 pm - 10:44 amSTL-SNA
17h 01m2 stops
$201Multiple Airlines
Find Deal
Thu, Dec 4 - Mon, Dec 8
Multiple Airlines Logo
6:45 am - 3:56 pmSNA-STL
7h 11m1 stop
Multiple Airlines Logo
9:54 pm - 6:46 pmSTL-SNA
22h 52m1 stop
$238Multiple Airlines
Find Deal
Sat, Nov 15 - Thu, Nov 20
Delta Logo
6:50 pm - 9:10 amSNA-STL
12h 20m2 stops
Delta Logo
6:00 am - 2:15 pmSTL-SNA
10h 15m2 stops
$344Delta
Find Deal
Thu, Dec 4 - Sat, Dec 6
Delta Logo
6:50 pm - 9:10 amSNA-STL
12h 20m2 stops
Delta Logo
2:20 pm - 10:21 pmSTL-SNA
10h 01m2 stops
$354Delta
Find Deal
Thu, Dec 4 - Mon, Dec 8
Southwest Logo
9:00 am - 5:10 pmSNA-STL
6h 10m2 stops
Southwest Logo
10:15 am - 5:55 pmSTL-SNA
9h 40m2 stops
$433Southwest
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Mon, Jan 26 - Thu, Jan 29
American Airlines Logo
4:25 pm - 11:51 pmSNA-STL
5h 26m1 stop
American Airlines Logo
6:00 am - 10:50 amSTL-SNA
6h 50m1 stop
$457American Airlines
Find Deal
Fri, Nov 28 - Tue, Dec 2

Frontier flights from Santa Ana, California to St. Louis

Our best Frontier deals on Santa Ana, California to St. Louis flight tickets
Frontier
Nov 15
SNA2:20 pmSanta Ana J. Wayne/Orange Cnty
16h 47m
1 stop
STL9:07 amLambert-St Louis
Nov 17
STL2:42 pmLambert-St Louis
6h 06m
1 stop
SNA6:48 pmSanta Ana J. Wayne/Orange Cnty
$130
Find similar
Frontier
Dec 4
SNA11:15 amSanta Ana J. Wayne/Orange Cnty
20h 59m
1 stop
STL10:14 amLambert-St Louis
Dec 7
STL9:14 pmLambert-St Louis
22h 25m
1 stop
SNA5:39 pmSanta Ana J. Wayne/Orange Cnty
$134
Find similar
Frontier
Jan 15
SNA8:18 pmSanta Ana J. Wayne/Orange Cnty
13h 57m
1 stop
STL12:15 pmLambert-St Louis
Jan 18
STL1:07 pmLambert-St Louis
8h 17m
1 stop
SNA7:24 pmSanta Ana J. Wayne/Orange Cnty
$138
Find similar

Delta flights from Santa Ana, California to St. Louis

Our best Delta deals on Santa Ana, California to St. Louis flight tickets
Delta
Dec 4
SNA6:50 pmSanta Ana J. Wayne/Orange Cnty
12h 20m
2 stops
STL9:10 amLambert-St Louis
Dec 6
STL6:00 amLambert-St Louis
10h 15m
2 stops
SNA2:15 pmSanta Ana J. Wayne/Orange Cnty
$344
Find similar
Delta
Dec 4
SNA6:50 pmSanta Ana J. Wayne/Orange Cnty
12h 20m
2 stops
STL9:10 amLambert-St Louis
Dec 8
STL2:20 pmLambert-St Louis
10h 01m
2 stops
SNA10:21 pmSanta Ana J. Wayne/Orange Cnty
$354
Find similar
Delta
Dec 4
SNA7:15 amSanta Ana J. Wayne/Orange Cnty
9h 55m
2 stops
STL7:10 pmLambert-St Louis
Dec 6
STL1:00 pmLambert-St Louis
9h 18m
1 stop
SNA8:18 pmSanta Ana J. Wayne/Orange Cnty
$385
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana, California to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from Santa Ana, California to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Sat 11/15

2:20 pm-9:07 am

1 stop16h 47m

Lambert-St Louis

Mon 11/17

2:42 pm-6:48 pm

1 stop6h 06m

$130

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 12/4

11:15 am-10:14 am

1 stop20h 59m

Lambert-St Louis

Sun 12/7

9:14 pm-5:39 pm

1 stop22h 25m

$134

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 1/15

8:18 pm-12:15 pm

1 stop13h 57m

Lambert-St Louis

Sun 1/18

1:07 pm-7:24 pm

1 stop8h 17m

$138

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 11/13

8:16 pm-8:12 pm

1 stop21h 56m

Lambert-St Louis

Sat 11/15

7:45 pm-11:16 am

1 stop17h 31m

$176

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 12/4

6:34 pm-12:12 pm

1 stop15h 38m

Lambert-St Louis

Mon 12/8

7:43 pm-10:44 am

2 stops17h 01m

$201

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Sat 11/15

6:45 am-3:56 pm

1 stop7h 11m

Lambert-St Louis

Thu 11/20

9:54 pm-6:46 pm

1 stop22h 52m

$238

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 12/4

6:50 pm-9:10 am

2 stops12h 20m

Lambert-St Louis

Sat 12/6

6:00 am-2:15 pm

2 stops10h 15m

$344

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 12/4

6:50 pm-9:10 am

2 stops12h 20m

Lambert-St Louis

Mon 12/8

2:20 pm-10:21 pm

2 stops10h 01m

$354

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Mon 1/26

9:00 am-5:10 pm

2 stops6h 10m

Lambert-St Louis

Thu 1/29

10:15 am-5:55 pm

2 stops9h 40m

$433

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Fri 11/28

4:25 pm-11:51 pm

1 stop5h 26m

Lambert-St Louis

Tue 12/2

6:00 am-10:50 am

1 stop6h 50m

$457

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Santa Ana, California to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, October is the cheapest month to fly from Santa Ana, California to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $357. The month of August is another great option to travel to St. Louis, with average flight prices from Santa Ana, California averaging around $374.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Thursday when prices can be found for as low as $393. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $432. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Santa Ana, California in the evening is the least expensive time of day to depart. momondo users have found prices as low as $378 when looking at flights departing in the evening. In the afternoon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $427 per ticket.

How far in advance should I book a flight to St. Louis?

You are more likely to see cheaper flights to St. Louis from Santa Ana, California when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $438 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from Santa Ana, California for as low as $339 on momondo.

How have Santa Ana, California to St. Louis flight prices changed over time?

As of November 2025, prices for Santa Ana, California to St. Louis flights are approximately 44% cheaper when compared to flights at the same time last year.

When to book flights from Santa Ana, California to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana, California to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana, California to St. Louis (SNA to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana, California to St. Louis

Direct flights

None
There are no direct flights from Santa Ana, California to St. Louis. There are no popular flight routes from Santa Ana, California to St. Louis.
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  • How far is Santa Ana J. Wayne/Orange Cnty to Lambert-St Louis by plane?

    The straight-line distance from Santa Ana J. Wayne/Orange Cnty to Lambert-St Louis is 1572.0 mi. By plane, this route typically takes 5h 26m.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents required for your trip to Lambert-St Louis Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Lambert-St Louis Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Santa Ana, California to St. Louis?

Best airlines flying from Santa Ana, California to St. Louis

Compare and see reviews for airlines that fly from Santa Ana, California to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $150Free CancellationRating
5.8
3,117 reviews
Search Frontier flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,002 reviews
Search Delta flights
American AirlinesPriceFrom $278Free CancellationRating
7.2
11,038 reviews
Search American Airlines flights
SouthwestPriceFrom $311Free CancellationRating
8.0
4,238 reviews
Search Southwest flights
United AirlinesPriceFrom $311Free CancellationRating
7.4
8,997 reviews
Search United Airlines flights

  • Southwest Flights From Santa Ana, California to St. Louis

    Southwest flies from Santa Ana, California to St. Louis around 3 times per week, with 4,240 momondo users rating the airline 8.0/10. The cheapest Southwest deal from Santa Ana, California to St. Louis in the last 72 hours was $311 (round-trip), much lower than the average airfare cost of $461 for Southwest flights on this route.

  • United Airlines Flights From Santa Ana, California to St. Louis

    United Airlines is also a popular choice for this route. United Airlines flight deals for Santa Ana, California to St. Louis start from as low as $311 round-trip, depending on your selected dates, with average United Airlines deals seen on momondo around $450. United Airlines operates 7 flights to St. Louis from Santa Ana, California in an average week. Users have rated it 7.4/10 across 8,997 reviews.

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Florissant
Maryland Heights
O'Fallon
Wentzville
Fenton
Collinsville
St. Peters
Alton
Farmington
Festus
Glencoe
Edwardsville
Clayton
Eureka
Litchfield
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santa Ana to St. Louis for you.

Can I find flights from Santa Ana to St. Louis with flexible booking policies on momondo?

All flight searches from Santa Ana to St. Louis on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Santa Ana to St. Louis?

momondo provides multiple filters to help you find the best flight to St. Louis from Santa Ana. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Santa Ana to St. Louis right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Santa Ana to St. Louis flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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