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Cheap flights from Santa Ana, California to St. Louis from $131

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana, California to St. Louis departing on 6/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Santa Ana, California to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
7:54 pm - 2:07 pm
SNA
-
STL
16h 13m
1 stop
Frontier Logo
8:08 pm - 8:09 am
STL
-
SNA
14h 01m
1 stop
$242Frontier
Fri, Aug 14 - Wed, Aug 19
Frontier Logo
8:10 pm - 6:06 pm
SNA
-
STL
19h 56m
1 stop
Frontier Logo
9:06 pm - 12:19 pm
STL
-
SNA
17h 13m
1 stop
$250Frontier
Mon, Jun 1 - Thu, Jun 4
Frontier Logo
8:55 am - 7:23 pm
SNA
-
STL
8h 28m
1 stop
Frontier Logo
8:08 pm - 8:05 am
STL
-
SNA
13h 57m
1 stop
$282Frontier
Fri, Jul 17 - Sun, Jul 19
Frontier Logo
11:07 am - 7:15 pm
SNA
-
STL
6h 08m
1 stop
Frontier Logo
12:46 pm - 5:35 pm
STL
-
SNA
6h 49m
1 stop
$290Frontier
Thu, Sep 17 - Mon, Sep 21
Frontier Logo
8:55 am - 7:23 pm
SNA
-
STL
8h 28m
1 stop
Frontier Logo
2:52 pm - 12:36 pm
STL
-
SNA
23h 44m
1 stop
$302Frontier
Fri, Jul 10 - Sun, Jul 12
Frontier Logo
7:54 pm - 7:23 pm
SNA
-
STL
21h 29m
2 stops
Frontier Logo
8:08 pm - 8:09 am
STL
-
SNA
14h 01m
1 stop
$311Frontier
Fri, Aug 14 - Wed, Aug 19
Frontier Logo
4:50 pm - 11:51 am
SNA
-
STL
17h 01m
1 stop
Frontier Logo
8:10 pm - 10:12 am
STL
-
SNA
16h 02m
1 stop
$321Frontier
Fri, Sep 18 - Sun, Sep 20
Frontier Logo
8:55 am - 7:23 pm
SNA
-
STL
8h 28m
1 stop
Frontier Logo
8:21 pm - 12:00 pm
STL
-
SNA
17h 39m
1 stop
$323Frontier
Mon, Aug 24 - Fri, Aug 28
Frontier Logo
8:10 pm - 7:23 pm
SNA
-
STL
21h 13m
2 stops
Frontier Logo
9:06 pm - 12:19 pm
STL
-
SNA
17h 13m
1 stop
$332Frontier
Mon, Jun 1 - Thu, Jun 4
Frontier Logo
8:10 pm - 2:06 pm
SNA
-
STL
15h 56m
1 stop
Frontier Logo
12:11 pm - 12:34 pm
STL
-
SNA
26h 23m
1 stop
$334Frontier
Fri, Jun 26 - Thu, Jul 2

Frontier flights from Santa Ana, California to St. Louis

Our best Frontier deals on Santa Ana, California to St. Louis flight tickets
Frontier
Aug 14
SNA7:54 pmSanta Ana J. Wayne/Orange Cnty
16h 13m
1 stop
STL2:07 pmLambert-St Louis
Aug 19
STL8:08 pmLambert-St Louis
14h 01m
1 stop
SNA8:09 amSanta Ana J. Wayne/Orange Cnty
$242
Frontier
Jun 1
SNA8:10 pmSanta Ana J. Wayne/Orange Cnty
19h 56m
1 stop
STL6:06 pmLambert-St Louis
Jun 4
STL9:06 pmLambert-St Louis
17h 13m
1 stop
SNA12:19 pmSanta Ana J. Wayne/Orange Cnty
$250
Frontier
Jul 17
SNA8:55 amSanta Ana J. Wayne/Orange Cnty
8h 28m
1 stop
STL7:23 pmLambert-St Louis
Jul 19
STL8:08 pmLambert-St Louis
13h 57m
1 stop
SNA8:05 amSanta Ana J. Wayne/Orange Cnty
$282

United Airlines flights from Santa Ana, California to St. Louis

Our best United Airlines deals on Santa Ana, California to St. Louis flight tickets
United Airlines
May 28
SNA4:00 pmSanta Ana J. Wayne/Orange Cnty
5h 57m
1 stop
STL11:57 pmLambert-St Louis
Jun 1
STL5:10 amLambert-St Louis
5h 57m
1 stop
SNA9:07 amSanta Ana J. Wayne/Orange Cnty
$470
United Airlines
May 28
SNA10:20 amSanta Ana J. Wayne/Orange Cnty
9h 01m
2 stops
STL9:21 pmLambert-St Louis
May 31
STL5:10 amLambert-St Louis
5h 57m
1 stop
SNA9:07 amSanta Ana J. Wayne/Orange Cnty
$642
United Airlines
May 26
SNA1:05 pmSanta Ana J. Wayne/Orange Cnty
6h 05m
1 stop
STL9:10 pmLambert-St Louis
May 28
STL5:10 amLambert-St Louis
10h 35m
2 stops
SNA1:45 pmSanta Ana J. Wayne/Orange Cnty
$780

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana, California to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 15, 2026.
Use the filters below to find and compare flights from Santa Ana, California to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Fri 8/14

7:54 pm-2:07 pm

1 stop16h 13m

Lambert-St Louis

Wed 8/19

8:08 pm-8:09 am

1 stop14h 01m

$242

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Mon 6/1

8:10 pm-6:06 pm

1 stop19h 56m

Lambert-St Louis

Thu 6/4

9:06 pm-12:19 pm

1 stop17h 13m

$250

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Fri 7/17

8:55 am-7:23 pm

1 stop8h 28m

Lambert-St Louis

Sun 7/19

8:08 pm-8:05 am

1 stop13h 57m

$282
Quickest round-trip

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 9/17

11:07 am-7:15 pm

1 stop6h 08m

Lambert-St Louis

Mon 9/21

12:46 pm-5:35 pm

1 stop6h 49m

$290

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Fri 7/10

8:55 am-7:23 pm

1 stop8h 28m

Lambert-St Louis

Sun 7/12

2:52 pm-12:36 pm

1 stop23h 44m

$302

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Fri 8/14

7:54 pm-7:23 pm

2 stops21h 29m

Lambert-St Louis

Wed 8/19

8:08 pm-8:09 am

1 stop14h 01m

$311

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Fri 9/18

4:50 pm-11:51 am

1 stop17h 01m

Lambert-St Louis

Sun 9/20

8:10 pm-10:12 am

1 stop16h 02m

$321

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Mon 8/24

8:55 am-7:23 pm

1 stop8h 28m

Lambert-St Louis

Fri 8/28

8:21 pm-12:00 pm

1 stop17h 39m

$323

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Mon 6/1

8:10 pm-7:23 pm

2 stops21h 13m

Lambert-St Louis

Thu 6/4

9:06 pm-12:19 pm

1 stop17h 13m

$332

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Fri 6/26

8:10 pm-2:06 pm

1 stop15h 56m

Lambert-St Louis

Thu 7/2

12:11 pm-12:34 pm

1 stop26h 23m

$334

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Santa Ana, California to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santa Ana, California and St. Louis?

What is the cheapest month to fly to St. Louis?

In general, October is the cheapest month to fly from Santa Ana, California to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $326. The month of August is another great option to travel to St. Louis, with average flight prices from Santa Ana, California averaging around $331.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Wednesday when prices can be found for as low as $394. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $517. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Santa Ana, California in the evening is the least expensive time of day to depart. momondo users have found prices as low as $334 when looking at flights departing in the evening. At noon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $495 per ticket.

How have Santa Ana, California to St. Louis flight prices changed over time?

As of May 2026, prices for Santa Ana, California to St. Louis flights are approximately 49% more expensive when compared to flights at the same time last year.

When to book flights from Santa Ana, California to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana, California to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana, California to St. Louis (SNA to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana, California to St. Louis

Fastest flight time

5h 31m

Direct flights

None
The fastest flight from Santa Ana, California to St. Louis takes 5h 31m
There are no direct flights from Santa Ana, California to St. Louis. There are no popular flight routes from Santa Ana, California to St. Louis.
Search flight deals

Frequently asked questions about flying from Santa Ana, California to St. Louis

  • How far is Santa Ana J. Wayne/Orange Cnty to Lambert-St Louis by plane?

    The straight-line distance from Santa Ana J. Wayne/Orange Cnty to Lambert-St Louis is 1572.0 mi. By plane, this route typically takes 5h 31m.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents required for your trip to Lambert-St Louis Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Lambert-St Louis Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Santa Ana, California to St. Louis?

Best airlines flying from Santa Ana, California to St. Louis

Compare and see reviews for airlines that fly from Santa Ana, California to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $150Free CancellationRating
5.6
2,951 reviews
Search Frontier flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,453 reviews
Search Delta flights
American AirlinesPriceFrom $277Free CancellationRating
7.1
11,662 reviews
Search American Airlines flights
SouthwestPriceFrom $306Free CancellationRating
8.0
4,299 reviews
Search Southwest flights
United AirlinesPriceFrom $311Free CancellationRating
7.4
9,717 reviews
Search United Airlines flights

  • Southwest Flights From Santa Ana, California to St. Louis

    Southwest flies from Santa Ana, California to St. Louis around 3 times per week, with 4,299 momondo users rating the airline 8.0/10. The cheapest Southwest deal from Santa Ana, California to St. Louis in the last 72 hours was $306 (round-trip), much lower than the average airfare cost of $482 for Southwest flights on this route.

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
O'Fallon
Florissant
St. Peters
Collinsville
Alton
Wentzville
Fenton
Farmington
Festus
Clayton
Eureka
Litchfield
Edwardsville
Shrewsbury
Grafton

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santa Ana to St. Louis for you.

Can I find flights from Santa Ana to St. Louis with flexible booking policies on momondo?

All flight searches from Santa Ana to St. Louis on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Santa Ana to St. Louis?

momondo provides multiple filters to help you find the best flight to St. Louis from Santa Ana. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Santa Ana to St. Louis right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Santa Ana to St. Louis flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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