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Cheap flights from Santa Ana, California to St. Louis from $80

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana, California to St. Louis departing on 4/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Santa Ana, California to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
7:56 pm - 11:22 am
SNA
-
STL
13h 26m
1 stop
Frontier Logo
9:55 pm - 3:01 pm
STL
-
SNA
19h 06m
1 stop
$210Frontier
Thu, Apr 30 - Sun, May 3
Frontier Logo
7:20 pm - 11:19 pm
SNA
-
STL
25h 59m
2 stops
Frontier Logo
8:06 pm - 11:25 am
STL
-
SNA
17h 19m
1 stop
$245Frontier
Mon, Apr 13 - Fri, Apr 17
Multiple Airlines Logo
9:54 am - 7:23 pm
SNA
-
STL
7h 29m
1 stop
Multiple Airlines Logo
6:51 pm - 3:38 pm
STL
-
SNA
22h 47m
1 stop
$252Multiple Airlines
Thu, May 7 - Tue, May 12
Multiple Airlines Logo
2:41 pm - 6:06 pm
SNA
-
STL
25h 25m
2 stops
Multiple Airlines Logo
9:18 pm - 3:23 pm
STL
-
SNA
20h 05m
1 stop
$254Multiple Airlines
Mon, May 4 - Mon, May 11
Multiple Airlines Logo
4:20 pm - 8:55 am
SNA
-
STL
14h 35m
2 stops
Multiple Airlines Logo
6:51 pm - 9:05 pm
STL
-
SNA
28h 14m
1 stop
$255Multiple Airlines
Thu, May 7 - Tue, May 12
Multiple Airlines Logo
11:11 am - 6:06 pm
SNA
-
STL
28h 55m
1 stop
Multiple Airlines Logo
9:18 pm - 3:23 pm
STL
-
SNA
20h 05m
1 stop
$258Multiple Airlines
Mon, May 4 - Mon, May 11
Multiple Airlines Logo
7:30 am - 6:06 pm
SNA
-
STL
8h 36m
1 stop
Multiple Airlines Logo
8:08 pm - 9:09 am
STL
-
SNA
15h 01m
1 stop
$264Multiple Airlines
Tue, May 12 - Fri, May 15
Multiple Airlines Logo
3:23 pm - 11:19 pm
SNA
-
STL
29h 56m
2 stops
Multiple Airlines Logo
8:17 pm - 10:44 am
STL
-
SNA
16h 27m
1 stop
$266Multiple Airlines
Tue, Apr 21 - Sat, Apr 25
Multiple Airlines Logo
11:14 am - 8:26 pm
SNA
-
STL
7h 12m
1 stop
Multiple Airlines Logo
8:08 pm - 12:19 pm
STL
-
SNA
42h 11m
2 stops
$268Multiple Airlines
Fri, May 29 - Tue, Jun 2
Frontier Logo
7:56 pm - 3:21 pm
SNA
-
STL
17h 25m
1 stop
Frontier Logo
8:06 pm - 11:25 am
STL
-
SNA
17h 19m
1 stop
$270Frontier
Fri, Apr 24 - Fri, May 1

United Airlines flights from Santa Ana, California to St. Louis

Our best United Airlines deals on Santa Ana, California to St. Louis flight tickets
United Airlines
Apr 23
SNA2:40 pmSanta Ana J. Wayne/Orange Cnty
6h 31m
1 stop
STL11:11 pmLambert-St Louis
Apr 30
STL6:00 amLambert-St Louis
7h 11m
1 stop
SNA11:11 amSanta Ana J. Wayne/Orange Cnty
$379
United Airlines
Apr 14
SNA9:00 amSanta Ana J. Wayne/Orange Cnty
11h 28m
2 stops
STL10:28 pmLambert-St Louis
Apr 30
STL6:00 amLambert-St Louis
7h 11m
1 stop
SNA11:11 amSanta Ana J. Wayne/Orange Cnty
$615
United Airlines
Apr 12
SNA7:44 pmSanta Ana J. Wayne/Orange Cnty
8h 06m
1 stop
STL5:50 amLambert-St Louis
Apr 17
STL6:05 pmLambert-St Louis
5h 53m
1 stop
SNA9:58 pmSanta Ana J. Wayne/Orange Cnty
$718

Southwest flights from Santa Ana, California to St. Louis

Our best Southwest deals on Santa Ana, California to St. Louis flight tickets
Southwest
Apr 23
SNA3:50 pmSanta Ana J. Wayne/Orange Cnty
6h 00m
1 stop
STL11:50 pmLambert-St Louis
Apr 30
STL5:45 amLambert-St Louis
8h 45m
2 stops
SNA12:30 pmSanta Ana J. Wayne/Orange Cnty
$413
Southwest
May 7
SNA8:50 amSanta Ana J. Wayne/Orange Cnty
10h 05m
2 stops
STL8:55 pmLambert-St Louis
May 12
STL8:25 amLambert-St Louis
8h 25m
2 stops
SNA2:50 pmSanta Ana J. Wayne/Orange Cnty
$416
Southwest
Apr 13
SNA7:45 amSanta Ana J. Wayne/Orange Cnty
9h 05m
1 stop
STL6:50 pmLambert-St Louis
Apr 14
STL8:25 amLambert-St Louis
10h 05m
2 stops
SNA4:30 pmSanta Ana J. Wayne/Orange Cnty
$582

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana, California to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 31, 2026.
Use the filters below to find and compare flights from Santa Ana, California to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 4/30

7:56 pm-11:22 am

1 stop13h 26m

Lambert-St Louis

Sun 5/3

9:55 pm-3:01 pm

1 stop19h 06m

$210

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Mon 4/13

7:20 pm-11:19 pm

2 stops25h 59m

Lambert-St Louis

Fri 4/17

8:06 pm-11:25 am

1 stop17h 19m

$245

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 5/7

9:54 am-7:23 pm

1 stop7h 29m

Lambert-St Louis

Tue 5/12

6:51 pm-3:38 pm

1 stop22h 47m

$252

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Mon 5/4

2:41 pm-6:06 pm

2 stops25h 25m

Lambert-St Louis

Mon 5/11

9:18 pm-3:23 pm

1 stop20h 05m

$254

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 5/7

4:20 pm-8:55 am

2 stops14h 35m

Lambert-St Louis

Tue 5/12

6:51 pm-9:05 pm

1 stop28h 14m

$255

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Mon 5/4

11:11 am-6:06 pm

1 stop28h 55m

Lambert-St Louis

Mon 5/11

9:18 pm-3:23 pm

1 stop20h 05m

$258
Quickest round-trip

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Tue 5/12

7:30 am-6:06 pm

1 stop8h 36m

Lambert-St Louis

Fri 5/15

8:08 pm-9:09 am

1 stop15h 01m

$264

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Tue 4/21

3:23 pm-11:19 pm

2 stops29h 56m

Lambert-St Louis

Sat 4/25

8:17 pm-10:44 am

1 stop16h 27m

$266

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Fri 5/29

11:14 am-8:26 pm

1 stop7h 12m

Lambert-St Louis

Tue 6/2

8:08 pm-12:19 pm

2 stops42h 11m

$268

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Fri 4/24

7:56 pm-3:21 pm

1 stop17h 25m

Lambert-St Louis

Fri 5/1

8:06 pm-11:25 am

1 stop17h 19m

$270

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Santa Ana, California to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santa Ana, California and St. Louis?

What is the cheapest month to fly to St. Louis?

In general, October is the cheapest month to fly from Santa Ana, California to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $326. The month of August is another great option to travel to St. Louis, with average flight prices from Santa Ana, California averaging around $331.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Wednesday when prices can be found for as low as $389. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $461. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Santa Ana, California in the evening is the least expensive time of day to depart. momondo users have found prices as low as $350 when looking at flights departing in the evening. At noon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $452 per ticket.

How have Santa Ana, California to St. Louis flight prices changed over time?

As of March 2026, prices for Santa Ana, California to St. Louis flights are approximately 22% more expensive when compared to flights at the same time last year.

When to book flights from Santa Ana, California to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana, California to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana, California to St. Louis (SNA to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana, California to St. Louis

Fastest flight time

5h 52m

Direct flights

None
The fastest flight from Santa Ana, California to St. Louis takes 5h 52m
There are no direct flights from Santa Ana, California to St. Louis. There are no popular flight routes from Santa Ana, California to St. Louis.
Search flight deals

  • How far is Santa Ana J. Wayne/Orange Cnty to Lambert-St Louis by plane?

    The straight-line distance from Santa Ana J. Wayne/Orange Cnty to Lambert-St Louis is 1572.0 mi. By plane, this route typically takes 5h 52m.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents required for your trip to Lambert-St Louis Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Lambert-St Louis Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Santa Ana, California to St. Louis?

Best airlines flying from Santa Ana, California to St. Louis

Compare and see reviews for airlines that fly from Santa Ana, California to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $150Free CancellationRating
5.7
3,008 reviews
Search Frontier flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,364 reviews
Search Delta flights
American AirlinesPriceFrom $278Free CancellationRating
7.1
11,543 reviews
Search American Airlines flights
SouthwestPriceFrom $306Free CancellationRating
8.0
4,332 reviews
Search Southwest flights
United AirlinesPriceFrom $311Free CancellationRating
7.4
9,525 reviews
Search United Airlines flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Florissant
Maryland Heights
O'Fallon
Collinsville
St. Peters
Wentzville
Alton
Fenton
Farmington
Clayton
Festus
Edwardsville
Eureka
Litchfield
Shrewsbury
Grafton

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santa Ana to St. Louis for you.

Can I find flights from Santa Ana to St. Louis with flexible booking policies on momondo?

All flight searches from Santa Ana to St. Louis on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Santa Ana to St. Louis?

momondo provides multiple filters to help you find the best flight to St. Louis from Santa Ana. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Santa Ana to St. Louis right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Santa Ana to St. Louis flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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