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Cheap flights from Santa Ana, California to St. Louis from $127

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana, California to St. Louis departing on 10/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Santa Ana, California to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
9:39 am - 7:13 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
7h 34m1 stop Denver Intl
Frontier Logo
7:58 pm - 8:24 amSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
14h 26m1 stop Denver Intl
$272Frontier
Thu, Sep 3 - Sun, Sep 6
Frontier Logo
4:35 pm - 7:17 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
24h 42m2 stops Las Vegas Harry Reid Intl Denver Intl
Frontier Logo
8:10 pm - 11:05 amSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
16h 55m1 stop Denver Intl
$273Frontier
Thu, Sep 24 - Wed, Sep 30
Multiple Airlines Logo
7:30 am - 7:15 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
9h 45m2 stops Las Vegas Harry Reid Intl Denver Intl
Multiple Airlines Logo
8:10 pm - 10:12 amSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
16h 02m1 stop Denver Intl
$275Multiple Airlines
Wed, Oct 21 - Fri, Oct 23
Multiple Airlines Logo
7:30 am - 1:17 amSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
15h 47m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
8:10 pm - 10:12 amSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
16h 02m1 stop Denver Intl
$301Multiple Airlines
Wed, Oct 21 - Fri, Oct 23
Southwest Logo
8:45 am - 5:50 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
7h 05m1 stop Las Vegas Harry Reid Intl
Southwest Logo
8:25 am - 1:10 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
6h 45m1 stop Sacramento Intl
$377Southwest
Wed, Sep 23 - Fri, Sep 25
Southwest Logo
6:45 am - 7:55 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
11h 10m2 stops Las Vegas Harry Reid Intl Houston Hobby
Southwest Logo
8:25 am - 1:10 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
6h 45m1 stop Sacramento Intl
$382Southwest
Wed, Sep 23 - Fri, Sep 25
American Airlines Logo
1:40 pm - 9:57 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
6h 17m1 stop Dallas/Fort Worth
American Airlines Logo
5:43 am - 10:50 amSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
7h 07m1 stop Dallas/Fort Worth
$407American Airlines
Thu, Sep 10 - Tue, Sep 15
American Airlines Logo
1:40 pm - 9:57 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
6h 17m1 stop Dallas/Fort Worth
American Airlines Logo
5:43 am - 10:50 amSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
7h 07m1 stop Dallas/Fort Worth
$429American Airlines
Thu, Sep 10 - Tue, Sep 15
Delta Logo
1:25 pm - 9:09 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
5h 44m1 stop Salt Lake City
Delta Logo
5:00 pm - 10:05 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
7h 05m1 stop Salt Lake City
$429Delta
Tue, Nov 3 - Sat, Nov 7
Delta Logo
6:02 pm - 8:40 amSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
12h 38m2 stops Seattle/Tacoma Intl Minneapolis St Paul
Delta Logo
11:16 am - 9:11 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
11h 55m2 stops Minneapolis St Paul Seattle/Tacoma Intl
$443Delta
Wed, Sep 23 - Sat, Sep 26

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American Airlines flights from Santa Ana, California to St. Louis

Our best American Airlines deals on Santa Ana, California to St. Louis flight tickets
American Airlines
Sep 10
SNA1:40 pmSanta Ana J. Wayne/Orange Cnty
6h 17m
1 stop
STL9:57 pmLambert-St Louis
Sep 15
STL5:43 amLambert-St Louis
7h 07m
1 stop
SNA10:50 amSanta Ana J. Wayne/Orange Cnty
$329
American Airlines
Aug 20
SNA3:21 pmSanta Ana J. Wayne/Orange Cnty
6h 53m
1 stop
STL12:14 amLambert-St Louis
Aug 23
STL6:36 amLambert-St Louis
8h 54m
1 stop
SNA1:30 pmSanta Ana J. Wayne/Orange Cnty
$1,303

Frontier flights from Santa Ana, California to St. Louis

Our best Frontier deals on Santa Ana, California to St. Louis flight tickets
Frontier
Sep 3
SNA9:39 amSanta Ana J. Wayne/Orange Cnty
7h 34m
1 stop
STL7:13 pmLambert-St Louis
Sep 6
STL7:58 pmLambert-St Louis
14h 26m
1 stop
SNA8:24 amSanta Ana J. Wayne/Orange Cnty
$272
Frontier
Sep 24
SNA4:35 pmSanta Ana J. Wayne/Orange Cnty
24h 42m
2 stops
STL7:17 pmLambert-St Louis
Sep 30
STL8:10 pmLambert-St Louis
16h 55m
1 stop
SNA11:05 amSanta Ana J. Wayne/Orange Cnty
$273
Frontier
Oct 26
SNA11:07 amSanta Ana J. Wayne/Orange Cnty
6h 08m
1 stop
STL7:15 pmLambert-St Louis
Nov 5
STL8:10 pmLambert-St Louis
16h 01m
1 stop
SNA10:11 amSanta Ana J. Wayne/Orange Cnty
$281

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana, California to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 10, 2026.
Use the filters below to find and compare flights from Santa Ana, California to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 9/3

9:39 am-7:13 pm

1 stop7h 34m

Lambert-St Louis

Sun 9/6

7:58 pm-8:24 am

1 stop14h 26m

$272

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 9/24

4:35 pm-7:17 pm

2 stops24h 42m

Lambert-St Louis

Wed 9/30

8:10 pm-11:05 am

1 stop16h 55m

$273

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Wed 10/21

7:30 am-7:15 pm

2 stops9h 45m

Lambert-St Louis

Fri 10/23

8:10 pm-10:12 am

1 stop16h 02m

$275

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Wed 10/21

7:30 am-1:17 am

1 stop15h 47m

Lambert-St Louis

Fri 10/23

8:10 pm-10:12 am

1 stop16h 02m

$301

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Wed 9/23

8:45 am-5:50 pm

1 stop7h 05m

Lambert-St Louis

Fri 9/25

8:25 am-1:10 pm

1 stop6h 45m

$377

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Wed 9/23

6:45 am-7:55 pm

2 stops11h 10m

Lambert-St Louis

Fri 9/25

8:25 am-1:10 pm

1 stop6h 45m

$382

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 9/10

1:40 pm-9:57 pm

1 stop6h 17m

Lambert-St Louis

Tue 9/15

5:43 am-10:50 am

1 stop7h 07m

$407

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 9/10

1:40 pm-9:57 pm

1 stop6h 17m

Lambert-St Louis

Tue 9/15

5:43 am-10:50 am

1 stop7h 07m

$429
Quickest round-trip

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Tue 11/3

1:25 pm-9:09 pm

1 stop5h 44m

Lambert-St Louis

Sat 11/7

5:00 pm-10:05 pm

1 stop7h 05m

$429

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Wed 9/23

6:02 pm-8:40 am

2 stops12h 38m

Lambert-St Louis

Sat 9/26

11:16 am-9:11 pm

2 stops11h 55m

$443

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Santa Ana, California to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santa Ana, California and St. Louis?

Prices are currently low for flights on this route.

Typical prices usually range from $473 to $689.
The lowest price recently found on this route was $272.

What is the cheapest month to fly to St. Louis?

In general, October is the cheapest month to fly from Santa Ana, California to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $332. The month of February is another great option to travel to St. Louis, with average flight prices from Santa Ana, California averaging around $422.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Thursday when prices can be found for as low as $418. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $566. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Santa Ana, California in the evening is the least expensive time of day to depart. momondo users have found prices as low as $331 when looking at flights departing in the evening. At noon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $572 per ticket.

How have Santa Ana, California to St. Louis flight prices changed over time?

As of August 2026, prices for Santa Ana, California to St. Louis flights are approximately 165% more expensive when compared to flights at the same time last year.

When to book flights from Santa Ana, California to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana, California to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana, California to St. Louis (SNA to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana, California to St. Louis

Fastest flight time

5h 17m

Direct flights

None
The fastest flight from Santa Ana, California to St. Louis takes 5h 17m
There are no direct flights from Santa Ana, California to St. Louis. There are no popular flight routes from Santa Ana, California to St. Louis.
Search flight deals

Frequently asked questions about flying from Santa Ana, California to St. Louis

  • How far is Santa Ana J. Wayne/Orange Cnty to Lambert-St Louis by plane?

    The straight-line distance from Santa Ana J. Wayne/Orange Cnty to Lambert-St Louis is 1572.0 mi. By plane, this route typically takes 5h 17m.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents required for your trip to Lambert-St Louis Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Lambert-St Louis Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Santa Ana, California to St. Louis?

Best airlines flying from Santa Ana, California to St. Louis

Compare and see reviews for airlines that fly from Santa Ana, California to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $129Free CancellationRating
5.6
2,715 reviews
Search Frontier flights
DeltaPriceFrom $276Free CancellationRating
7.8
8,497 reviews
Search Delta flights
United AirlinesPriceFrom $311Free CancellationRating
7.4
10,097 reviews
Search United Airlines flights
SouthwestPriceFrom $316Free CancellationRating
8.0
4,214 reviews
Search Southwest flights
American AirlinesPriceFrom $317Free CancellationRating
7.1
11,897 reviews
Search American Airlines flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Fairview Heights
Hermann
St. Peters
Maryland Heights
Florissant
Collinsville
Alton
O'Fallon
Clayton
Farmington
Fenton
Wentzville
Festus
Eureka
Edwardsville
Litchfield
Grafton
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santa Ana to St. Louis for you.

Can I find flights from Santa Ana to St. Louis with flexible booking policies on momondo?

All flight searches from Santa Ana to St. Louis on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Santa Ana to St. Louis?

momondo provides multiple filters to help you find the best flight to St. Louis from Santa Ana. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Santa Ana to St. Louis right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Santa Ana to St. Louis flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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