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Cheap flights from Santa Ana, California to St. Louis from $78

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana, California to St. Louis departing on 2/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Santa Ana, California to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
4:37 pm - 12:40 pm
SNA
-
STL
18h 03m1 stop
Multiple Airlines Logo
3:46 pm - 10:58 am
STL
-
SNA
21h 12m1 stop
$153Multiple Airlines
Wed, Jan 14 - Wed, Jan 21
Multiple Airlines Logo
6:45 am - 8:48 pm
SNA
-
STL
12h 03m1 stop
Multiple Airlines Logo
9:32 pm - 8:57 pm
STL
-
SNA
25h 25m1 stop
$154Multiple Airlines
Fri, Feb 6 - Sun, Feb 8
Multiple Airlines Logo
4:37 pm - 12:40 pm
SNA
-
STL
18h 03m1 stop
Multiple Airlines Logo
3:43 pm - 10:43 am
STL
-
SNA
21h 00m1 stop
$158Multiple Airlines
Thu, Jan 15 - Sat, Jan 17
Multiple Airlines Logo
6:45 am - 9:06 pm
SNA
-
STL
12h 21m1 stop
Multiple Airlines Logo
10:01 pm - 12:25 pm
STL
-
SNA
16h 24m1 stop
$161Multiple Airlines
Thu, Jan 22 - Thu, Jan 29
Multiple Airlines Logo
4:37 pm - 12:40 pm
SNA
-
STL
18h 03m1 stop
Multiple Airlines Logo
3:46 pm - 3:42 pm
STL
-
SNA
25h 56m2 stops
$174Multiple Airlines
Wed, Jan 14 - Wed, Jan 21
Multiple Airlines Logo
6:45 am - 8:48 pm
SNA
-
STL
12h 03m1 stop
Multiple Airlines Logo
9:32 pm - 2:11 pm
STL
-
SNA
18h 39m2 stops
$186Multiple Airlines
Fri, Feb 6 - Sun, Feb 8
Multiple Airlines Logo
6:45 am - 9:14 pm
SNA
-
STL
12h 29m1 stop
Multiple Airlines Logo
7:39 pm - 8:57 pm
STL
-
SNA
27h 18m2 stops
$191Multiple Airlines
Fri, Jan 16 - Fri, Jan 23
Multiple Airlines Logo
6:45 am - 9:06 pm
SNA
-
STL
12h 21m1 stop
Multiple Airlines Logo
10:01 pm - 6:46 pm
STL
-
SNA
22h 45m2 stops
$197Multiple Airlines
Thu, Jan 22 - Thu, Jan 29
Frontier Logo
1:31 pm - 9:21 pm
SNA
-
STL
5h 50m1 stop
Frontier Logo
1:07 pm - 7:18 pm
STL
-
SNA
8h 11m1 stop
$217Frontier
Fri, Jan 9 - Mon, Jan 12
Frontier Logo
2:39 pm - 8:48 pm
SNA
-
STL
28h 09m1 stop
Frontier Logo
9:27 pm - 6:01 pm
STL
-
SNA
22h 34m1 stop
$218Frontier
Thu, Jan 22 - Sun, Jan 25

Frontier flights from Santa Ana, California to St. Louis

Our best Frontier deals on Santa Ana, California to St. Louis flight tickets
Frontier
Jan 9
SNA1:31 pmSanta Ana J. Wayne/Orange Cnty
5h 50m
1 stop
STL9:21 pmLambert-St Louis
Jan 12
STL1:07 pmLambert-St Louis
8h 11m
1 stop
SNA7:18 pmSanta Ana J. Wayne/Orange Cnty
$217
Find similar
Frontier
Jan 22
SNA2:39 pmSanta Ana J. Wayne/Orange Cnty
28h 09m
1 stop
STL8:48 pmLambert-St Louis
Jan 25
STL9:27 pmLambert-St Louis
22h 34m
1 stop
SNA6:01 pmSanta Ana J. Wayne/Orange Cnty
$218
Find similar
Frontier
Jan 25
SNA2:27 pmSanta Ana J. Wayne/Orange Cnty
20h 23m
2 stops
STL12:50 pmLambert-St Louis
Jan 28
STL3:46 pmLambert-St Louis
21h 12m
1 stop
SNA10:58 amSanta Ana J. Wayne/Orange Cnty
$245
Find similar

Southwest flights from Santa Ana, California to St. Louis

Our best Southwest deals on Santa Ana, California to St. Louis flight tickets
Southwest
Feb 6
SNA1:30 pmSanta Ana J. Wayne/Orange Cnty
8h 15m
2 stops
STL11:45 pmLambert-St Louis
Feb 8
STL8:20 amLambert-St Louis
12h 00m
2 stops
SNA6:20 pmSanta Ana J. Wayne/Orange Cnty
$391
Find similar
Southwest
Jan 25
SNA7:45 amSanta Ana J. Wayne/Orange Cnty
8h 05m
2 stops
STL5:50 pmLambert-St Louis
Jan 28
STL2:15 pmLambert-St Louis
7h 35m
2 stops
SNA7:50 pmSanta Ana J. Wayne/Orange Cnty
$453
Find similar
Southwest
Dec 24
SNA7:30 amSanta Ana J. Wayne/Orange Cnty
7h 50m
2 stops
STL5:20 pmLambert-St Louis
Dec 31
STL1:45 pmLambert-St Louis
8h 30m
2 stops
SNA8:15 pmSanta Ana J. Wayne/Orange Cnty
$786
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana, California to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Santa Ana, California to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Wed 1/14

4:37 pm-12:40 pm

1 stop18h 03m

Lambert-St Louis

Wed 1/21

3:46 pm-10:58 am

1 stop21h 12m

$153

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Fri 2/6

6:45 am-8:48 pm

1 stop12h 03m

Lambert-St Louis

Sun 2/8

9:32 pm-8:57 pm

1 stop25h 25m

$154

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 1/15

4:37 pm-12:40 pm

1 stop18h 03m

Lambert-St Louis

Sat 1/17

3:43 pm-10:43 am

1 stop21h 00m

$158

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 1/22

6:45 am-9:06 pm

1 stop12h 21m

Lambert-St Louis

Thu 1/29

10:01 pm-12:25 pm

1 stop16h 24m

$161

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Wed 1/14

4:37 pm-12:40 pm

1 stop18h 03m

Lambert-St Louis

Wed 1/21

3:46 pm-3:42 pm

2 stops25h 56m

$174

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Fri 2/6

6:45 am-8:48 pm

1 stop12h 03m

Lambert-St Louis

Sun 2/8

9:32 pm-2:11 pm

2 stops18h 39m

$186

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Fri 1/16

6:45 am-9:14 pm

1 stop12h 29m

Lambert-St Louis

Fri 1/23

7:39 pm-8:57 pm

2 stops27h 18m

$191

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 1/22

6:45 am-9:06 pm

1 stop12h 21m

Lambert-St Louis

Thu 1/29

10:01 pm-6:46 pm

2 stops22h 45m

$197

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Fri 1/9

1:31 pm-9:21 pm

1 stop5h 50m

Lambert-St Louis

Mon 1/12

1:07 pm-7:18 pm

1 stop8h 11m

$217

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 1/22

2:39 pm-8:48 pm

1 stop28h 09m

Lambert-St Louis

Sun 1/25

9:27 pm-6:01 pm

1 stop22h 34m

$218

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Santa Ana, California to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, October is the cheapest month to fly from Santa Ana, California to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $329. The month of August is another great option to travel to St. Louis, with average flight prices from Santa Ana, California averaging around $374.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Thursday when prices can be found for as low as $388. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $431. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Santa Ana, California in the evening is the least expensive time of day to depart. momondo users have found prices as low as $356 when looking at flights departing in the evening. In the afternoon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $417 per ticket.

How have Santa Ana, California to St. Louis flight prices changed over time?

As of December 2025, prices for Santa Ana, California to St. Louis flights are approximately 83% more expensive when compared to flights at the same time last year.

When to book flights from Santa Ana, California to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana, California to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana, California to St. Louis (SNA to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana, California to St. Louis

Fastest flight time

5h 08m

Direct flights

None
The fastest flight from Santa Ana, California to St. Louis takes 5h 08m
There are no direct flights from Santa Ana, California to St. Louis. There are no popular flight routes from Santa Ana, California to St. Louis.
Search flight deals

  • How far is Santa Ana J. Wayne/Orange Cnty to Lambert-St Louis by plane?

    The straight-line distance from Santa Ana J. Wayne/Orange Cnty to Lambert-St Louis is 1572.0 mi. By plane, this route typically takes 5h 08m.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents required for your trip to Lambert-St Louis Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Lambert-St Louis Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Santa Ana, California to St. Louis?

Best airlines flying from Santa Ana, California to St. Louis

Compare and see reviews for airlines that fly from Santa Ana, California to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $150Free CancellationRating
5.8
3,081 reviews
Search Frontier flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,005 reviews
Search Delta flights
American AirlinesPriceFrom $278Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights
SouthwestPriceFrom $306Free CancellationRating
7.9
4,250 reviews
Search Southwest flights
United AirlinesPriceFrom $311Free CancellationRating
7.4
9,091 reviews
Search United Airlines flights

  • Southwest Flights From Santa Ana, California to St. Louis

    Southwest flies from Santa Ana, California to St. Louis around 1 time per week, with 4,250 momondo users rating the airline 7.9/10. The cheapest Southwest deal from Santa Ana, California to St. Louis in the last 72 hours was $306 (round-trip), much lower than the average airfare cost of $461 for Southwest flights on this route.

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
O'Fallon
Florissant
Fenton
Wentzville
St. Peters
Collinsville
Alton
Clayton
Festus
Glencoe
Farmington
Eureka
Edwardsville
Litchfield
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santa Ana to St. Louis for you.

Can I find flights from Santa Ana to St. Louis with flexible booking policies on momondo?

All flight searches from Santa Ana to St. Louis on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Santa Ana to St. Louis?

momondo provides multiple filters to help you find the best flight to St. Louis from Santa Ana. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Santa Ana to St. Louis right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Santa Ana to St. Louis flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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