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Cheap flights from Santa Ana, California to St. Louis from $112

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Santa Ana, California to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:30 am - 5:40 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
32h 10m2 stops Las Vegas Harry Reid Intl Atlanta Hartsfield-Jackson
Multiple Airlines Logo
7:59 pm - 10:46 amSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
16h 47m1 stop Denver Intl
$293Multiple Airlines
Tue, Nov 3 - Sat, Nov 7
Multiple Airlines Logo
8:33 pm - 7:14 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
20h 41m2 stops Phoenix-Mesa Gateway Denver Intl
Multiple Airlines Logo
7:59 pm - 10:46 amSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
16h 47m1 stop Denver Intl
$306Multiple Airlines
Thu, Nov 5 - Sat, Nov 7
American Airlines Logo
11:40 am - 11:59 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
10h 19m1 stop Chicago O'Hare Intl
American Airlines Logo
5:00 am - 2:33 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
11h 33m1 stop Chicago O'Hare Intl
$395American Airlines
Tue, Nov 3 - Sat, Nov 7
American Airlines Logo
11:40 am - 11:59 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
10h 19m1 stop Chicago O'Hare Intl
American Airlines Logo
8:47 am - 2:07 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
7h 20m1 stop Dallas/Fort Worth
$397American Airlines
Wed, Nov 18 - Thu, Nov 19
Southwest Logo
12:10 pm - 9:05 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
6h 55m1 stop Denver Intl
Southwest Logo
5:05 am - 11:20 amSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
8h 15m1 stop Las Vegas Harry Reid Intl
$399Southwest
Tue, Dec 1 - Thu, Dec 31
Delta Logo
9:53 am - 5:41 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
5h 48m1 stop Salt Lake City
Delta Logo
5:00 pm - 10:02 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
7h 02m1 stop Salt Lake City
$399Delta
Thu, Nov 12 - Sat, Nov 14
Southwest Logo
6:45 am - 5:25 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
8h 40m2 stops Phoenix Sky Harbor Intl Omaha Eppley Airfield
Southwest Logo
6:25 am - 11:20 amSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
6h 55m1 stop Las Vegas Harry Reid Intl
$404Southwest
Wed, Nov 18 - Thu, Nov 19
Delta Logo
7:00 am - 5:44 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
8h 44m1 stop Salt Lake City
Delta Logo
2:22 pm - 10:30 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
10h 08m2 stops Salt Lake City Seattle/Tacoma Intl
$411Delta
Wed, Oct 21 - Fri, Oct 23
United Airlines Logo
6:50 am - 9:40 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
12h 50m2 stops Denver Intl Chicago O'Hare Intl
United Airlines Logo
8:50 am - 10:00 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
15h 10m1 stop Denver Intl
$488United Airlines
Thu, Oct 29 - Mon, Nov 2
United Airlines Logo
6:50 am - 9:40 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
12h 50m2 stops Denver Intl Chicago O'Hare Intl
United Airlines Logo
10:53 am - 9:19 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
12h 26m2 stops Chicago O'Hare Intl Denver Intl
$493United Airlines
Thu, Oct 29 - Mon, Nov 2

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Frontier flights from Santa Ana, California to St. Louis

Our best Frontier deals on Santa Ana, California to St. Louis flight tickets
Frontier
Oct 5
SNA4:35 pmSanta Ana J. Wayne/Orange Cnty
16h 57m
1 stop
STL11:32 amLambert-St Louis
Oct 12
STL1:30 pmLambert-St Louis
7h 44m
1 stop
SNA7:14 pmSanta Ana J. Wayne/Orange Cnty
$338
Frontier
Nov 5
SNA3:55 pmSanta Ana J. Wayne/Orange Cnty
18h 38m
1 stop
STL12:33 pmLambert-St Louis
Nov 7
STL7:59 pmLambert-St Louis
16h 47m
1 stop
SNA10:46 amSanta Ana J. Wayne/Orange Cnty
$345
Frontier
Oct 23
SNA11:38 amSanta Ana J. Wayne/Orange Cnty
5h 37m
1 stop
STL7:15 pmLambert-St Louis
Oct 29
STL12:14 pmLambert-St Louis
7h 52m
1 stop
SNA6:06 pmSanta Ana J. Wayne/Orange Cnty
$348

Southwest flights from Santa Ana, California to St. Louis

Our best Southwest deals on Santa Ana, California to St. Louis flight tickets
Southwest
Nov 18
SNA6:45 amSanta Ana J. Wayne/Orange Cnty
8h 40m
2 stops
STL5:25 pmLambert-St Louis
Nov 19
STL6:25 amLambert-St Louis
6h 55m
1 stop
SNA11:20 amSanta Ana J. Wayne/Orange Cnty
$404
Southwest
Oct 22
SNA9:00 amSanta Ana J. Wayne/Orange Cnty
8h 05m
1 stop
STL7:05 pmLambert-St Louis
Oct 23
STL6:00 amLambert-St Louis
7h 55m
2 stops
SNA11:55 amSanta Ana J. Wayne/Orange Cnty
$429
Southwest
Oct 5
SNA2:55 pmSanta Ana J. Wayne/Orange Cnty
6h 30m
1 stop
STL11:25 pmLambert-St Louis
Oct 12
STL6:00 amLambert-St Louis
7h 55m
2 stops
SNA11:55 amSanta Ana J. Wayne/Orange Cnty
$446

momondo Fare Finder

 
Use the filters below to find and compare flights from Santa Ana, California to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Tue 11/3

7:30 am-5:40 pm

2 stops32h 10m

Lambert-St Louis

Sat 11/7

7:59 pm-10:46 am

1 stop16h 47m

$293

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 11/5

8:33 pm-7:14 pm

2 stops20h 41m

Lambert-St Louis

Sat 11/7

7:59 pm-10:46 am

1 stop16h 47m

$306

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Tue 11/3

11:40 am-11:59 pm

1 stop10h 19m

Lambert-St Louis

Sat 11/7

5:00 am-2:33 pm

1 stop11h 33m

$395

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Wed 11/18

11:40 am-11:59 pm

1 stop10h 19m

Lambert-St Louis

Thu 11/19

8:47 am-2:07 pm

1 stop7h 20m

$397

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Tue 12/1

12:10 pm-9:05 pm

1 stop6h 55m

Lambert-St Louis

Thu 12/31

5:05 am-11:20 am

1 stop8h 15m

$399
Quickest round-trip

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 11/12

9:53 am-5:41 pm

1 stop5h 48m

Lambert-St Louis

Sat 11/14

5:00 pm-10:02 pm

1 stop7h 02m

$399

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Wed 11/18

6:45 am-5:25 pm

2 stops8h 40m

Lambert-St Louis

Thu 11/19

6:25 am-11:20 am

1 stop6h 55m

$404

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Wed 10/21

7:00 am-5:44 pm

1 stop8h 44m

Lambert-St Louis

Fri 10/23

2:22 pm-10:30 pm

2 stops10h 08m

$411

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 10/29

6:50 am-9:40 pm

2 stops12h 50m

Lambert-St Louis

Mon 11/2

8:50 am-10:00 pm

1 stop15h 10m

$488

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 10/29

6:50 am-9:40 pm

2 stops12h 50m

Lambert-St Louis

Mon 11/2

10:53 am-9:19 pm

2 stops12h 26m

$493

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Santa Ana, California to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santa Ana, California and St. Louis?

Prices are currently low for flights on this route.

Typical prices usually range from $403 to $556.
The lowest price recently found on this route was $293.

What is the cheapest month to fly to St. Louis?

In general, October is the cheapest month to fly from Santa Ana, California to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $345. The month of February is another great option to travel to St. Louis, with average flight prices from Santa Ana, California averaging around $416.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Tuesday when prices can be found for as low as $425. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $579. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Santa Ana, California in the evening is the least expensive time of day to depart. momondo users have found prices as low as $362 when looking at flights departing in the evening. At noon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $576 per ticket.

How have Santa Ana, California to St. Louis flight prices changed over time?

As of September 2026, prices for Santa Ana, California to St. Louis flights are approximately 5% more expensive when compared to flights at the same time last year.

When to book flights from Santa Ana, California to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana, California to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana, California to St. Louis (SNA to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana, California to St. Louis

Best Price Found

$112

Fastest flight time

4h 55m

Direct flights

None
The best one-way flight to St. Louis from Santa Ana, California in the past 72 hours is $112. The best round-trip flight deal from Santa Ana, California to St. Louis found on momondo in the last 72 hours is $293.
The fastest flight from Santa Ana, California to St. Louis takes 4h 55m
There are no direct flights from Santa Ana, California to St. Louis. There are no popular flight routes from Santa Ana, California to St. Louis.
Search flight deals

Frequently asked questions about flying from Santa Ana, California to St. Louis

  • How far is Santa Ana J. Wayne/Orange Cnty to Lambert-St Louis by plane?

    The straight-line distance from Santa Ana J. Wayne/Orange Cnty to Lambert-St Louis is 1572.0 mi. By plane, this route typically takes 4h 55m.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents required for your trip to Lambert-St Louis Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Lambert-St Louis Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Santa Ana, California to St. Louis?

Best airlines flying from Santa Ana, California to St. Louis

Compare and see reviews for airlines that fly from Santa Ana, California to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $276Free CancellationRating
7.8
8,567 reviews
Search Delta flights
United AirlinesPriceFrom $311Free CancellationRating
7.4
10,207 reviews
Search United Airlines flights
American AirlinesPriceFrom $328Free CancellationRating
7.1
12,051 reviews
Search American Airlines flights
SouthwestPriceFrom $346Free CancellationRating
8.0
4,191 reviews
Search Southwest flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Fairview Heights
Maryland Heights
St. Peters
Alton
Collinsville
Florissant
Hermann
O'Fallon
Clayton
Farmington
Fenton
Festus
Wentzville
Edwardsville
Eureka
Litchfield
Grafton
Waterloo

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santa Ana to St. Louis for you.

Can I find flights from Santa Ana to St. Louis with flexible booking policies on momondo?

All flight searches from Santa Ana to St. Louis on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Santa Ana to St. Louis?

momondo provides multiple filters to help you find the best flight to St. Louis from Santa Ana. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Santa Ana to St. Louis right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Santa Ana to St. Louis flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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