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Cheap flights from Santa Ana, California to St. Louis from $86

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana, California to St. Louis departing on 5/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Santa Ana, California to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
7:56 pm - 3:21 pm
SNA
-
STL
17h 25m
1 stop
Frontier Logo
9:55 pm - 3:01 pm
STL
-
SNA
19h 06m
1 stop
$210Frontier
Fri, May 1 - Sun, May 3
Frontier Logo
7:56 pm - 11:22 am
SNA
-
STL
13h 26m
1 stop
Frontier Logo
12:16 pm - 12:19 pm
STL
-
SNA
26h 03m
1 stop
$225Frontier
Thu, Apr 30 - Thu, May 7
Frontier Logo
8:10 pm - 7:23 pm
SNA
-
STL
21h 13m
2 stops
Frontier Logo
8:08 pm - 8:09 am
STL
-
SNA
14h 01m
1 stop
$237Frontier
Mon, Jun 1 - Wed, Jun 10
Multiple Airlines Logo
7:45 am - 6:06 pm
SNA
-
STL
8h 21m
1 stop
Multiple Airlines Logo
9:18 pm - 9:09 am
STL
-
SNA
13h 51m
2 stops
$245Multiple Airlines
Tue, May 12 - Fri, May 15
Frontier Logo
8:55 am - 7:23 pm
SNA
-
STL
8h 28m
1 stop
Frontier Logo
8:21 pm - 12:00 pm
STL
-
SNA
17h 39m
1 stop
$250Frontier
Thu, Jul 9 - Sun, Jul 12
Multiple Airlines Logo
12:10 pm - 10:31 am
SNA
-
STL
20h 21m
2 stops
Multiple Airlines Logo
9:55 pm - 4:20 pm
STL
-
SNA
20h 25m
1 stop
$254Multiple Airlines
Sat, May 2 - Sun, May 3
Multiple Airlines Logo
7:30 am - 6:06 pm
SNA
-
STL
8h 36m
1 stop
Multiple Airlines Logo
8:08 pm - 9:09 am
STL
-
SNA
15h 01m
1 stop
$264Multiple Airlines
Tue, May 12 - Fri, May 15
Multiple Airlines Logo
7:45 am - 8:11 pm
SNA
-
STL
10h 26m
1 stop
Multiple Airlines Logo
8:08 pm - 12:19 pm
STL
-
SNA
42h 11m
2 stops
$271Multiple Airlines
Fri, May 29 - Tue, Jun 2
Multiple Airlines Logo
7:30 am - 7:23 pm
SNA
-
STL
33h 53m
2 stops
Multiple Airlines Logo
8:08 pm - 8:09 am
STL
-
SNA
14h 01m
1 stop
$272Multiple Airlines
Tue, Jun 2 - Wed, Jun 10
Frontier Logo
12:10 pm - 10:31 am
SNA
-
STL
20h 21m
2 stops
Frontier Logo
6:51 pm - 12:19 pm
STL
-
SNA
19h 28m
1 stop
$286Frontier
Sat, May 2 - Wed, May 6

Frontier flights from Santa Ana, California to St. Louis

Our best Frontier deals on Santa Ana, California to St. Louis flight tickets
Frontier
May 1
SNA7:56 pmSanta Ana J. Wayne/Orange Cnty
17h 25m
1 stop
STL3:21 pmLambert-St Louis
May 3
STL9:55 pmLambert-St Louis
19h 06m
1 stop
SNA3:01 pmSanta Ana J. Wayne/Orange Cnty
$210
Frontier
Apr 30
SNA7:56 pmSanta Ana J. Wayne/Orange Cnty
13h 26m
1 stop
STL11:22 amLambert-St Louis
May 7
STL12:16 pmLambert-St Louis
26h 03m
1 stop
SNA12:19 pmSanta Ana J. Wayne/Orange Cnty
$225
Frontier
Jun 1
SNA8:10 pmSanta Ana J. Wayne/Orange Cnty
21h 13m
2 stops
STL7:23 pmLambert-St Louis
Jun 10
STL8:08 pmLambert-St Louis
14h 01m
1 stop
SNA8:09 amSanta Ana J. Wayne/Orange Cnty
$237

Southwest flights from Santa Ana, California to St. Louis

Our best Southwest deals on Santa Ana, California to St. Louis flight tickets
Southwest
Apr 16
SNA8:50 amSanta Ana J. Wayne/Orange Cnty
10h 05m
2 stops
STL8:55 pmLambert-St Louis
May 8
STL3:50 pmLambert-St Louis
6h 30m
2 stops
SNA8:20 pmSanta Ana J. Wayne/Orange Cnty
$543
Southwest
Apr 18
SNA9:00 amSanta Ana J. Wayne/Orange Cnty
7h 10m
2 stops
STL6:10 pmLambert-St Louis
Apr 20
STL3:50 pmLambert-St Louis
6h 30m
2 stops
SNA8:20 pmSanta Ana J. Wayne/Orange Cnty
$583
Southwest
Apr 15
SNA7:25 amSanta Ana J. Wayne/Orange Cnty
8h 30m
2 stops
STL5:55 pmLambert-St Louis
Apr 18
STL8:45 amLambert-St Louis
8h 35m
2 stops
SNA3:20 pmSanta Ana J. Wayne/Orange Cnty
$587

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana, California to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 5, 2026.
Use the filters below to find and compare flights from Santa Ana, California to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Fri 5/1

7:56 pm-3:21 pm

1 stop17h 25m

Lambert-St Louis

Sun 5/3

9:55 pm-3:01 pm

1 stop19h 06m

$210

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 4/30

7:56 pm-11:22 am

1 stop13h 26m

Lambert-St Louis

Thu 5/7

12:16 pm-12:19 pm

1 stop26h 03m

$225

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Mon 6/1

8:10 pm-7:23 pm

2 stops21h 13m

Lambert-St Louis

Wed 6/10

8:08 pm-8:09 am

1 stop14h 01m

$237
Quickest round-trip

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Tue 5/12

7:45 am-6:06 pm

1 stop8h 21m

Lambert-St Louis

Fri 5/15

9:18 pm-9:09 am

2 stops13h 51m

$245

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 7/9

8:55 am-7:23 pm

1 stop8h 28m

Lambert-St Louis

Sun 7/12

8:21 pm-12:00 pm

1 stop17h 39m

$250

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Sat 5/2

12:10 pm-10:31 am

2 stops20h 21m

Lambert-St Louis

Sun 5/3

9:55 pm-4:20 pm

1 stop20h 25m

$254

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Tue 5/12

7:30 am-6:06 pm

1 stop8h 36m

Lambert-St Louis

Fri 5/15

8:08 pm-9:09 am

1 stop15h 01m

$264

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Fri 5/29

7:45 am-8:11 pm

1 stop10h 26m

Lambert-St Louis

Tue 6/2

8:08 pm-12:19 pm

2 stops42h 11m

$271

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Tue 6/2

7:30 am-7:23 pm

2 stops33h 53m

Lambert-St Louis

Wed 6/10

8:08 pm-8:09 am

1 stop14h 01m

$272

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Sat 5/2

12:10 pm-10:31 am

2 stops20h 21m

Lambert-St Louis

Wed 5/6

6:51 pm-12:19 pm

1 stop19h 28m

$286

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Santa Ana, California to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santa Ana, California and St. Louis?

What is the cheapest month to fly to St. Louis?

In general, October is the cheapest month to fly from Santa Ana, California to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $326. The month of August is another great option to travel to St. Louis, with average flight prices from Santa Ana, California averaging around $331.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Wednesday when prices can be found for as low as $389. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $482. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Santa Ana, California in the evening is the least expensive time of day to depart. momondo users have found prices as low as $350 when looking at flights departing in the evening. At noon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $452 per ticket.

How have Santa Ana, California to St. Louis flight prices changed over time?

As of April 2026, prices for Santa Ana, California to St. Louis flights are approximately 86% more expensive when compared to flights at the same time last year.

When to book flights from Santa Ana, California to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana, California to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana, California to St. Louis (SNA to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana, California to St. Louis

Fastest flight time

5h 00m

Direct flights

None
The fastest flight from Santa Ana, California to St. Louis takes 5h 00m
There are no direct flights from Santa Ana, California to St. Louis. There are no popular flight routes from Santa Ana, California to St. Louis.
Search flight deals

Frequently asked questions about flying from Santa Ana, California to St. Louis

  • How far is Santa Ana J. Wayne/Orange Cnty to Lambert-St Louis by plane?

    The straight-line distance from Santa Ana J. Wayne/Orange Cnty to Lambert-St Louis is 1572.0 mi. By plane, this route typically takes 5h 00m.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents required for your trip to Lambert-St Louis Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Lambert-St Louis Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Santa Ana, California to St. Louis?

Best airlines flying from Santa Ana, California to St. Louis

Compare and see reviews for airlines that fly from Santa Ana, California to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $150Free CancellationRating
5.7
3,001 reviews
Search Frontier flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,386 reviews
Search Delta flights
American AirlinesPriceFrom $278Free CancellationRating
7.1
11,555 reviews
Search American Airlines flights
SouthwestPriceFrom $306Free CancellationRating
8.0
4,341 reviews
Search Southwest flights
United AirlinesPriceFrom $311Free CancellationRating
7.4
9,545 reviews
Search United Airlines flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
O'Fallon
Florissant
St. Peters
Collinsville
Alton
Wentzville
Fenton
Farmington
Clayton
Festus
Eureka
Edwardsville
Litchfield
Shrewsbury
Grafton

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santa Ana to St. Louis for you.

Can I find flights from Santa Ana to St. Louis with flexible booking policies on momondo?

All flight searches from Santa Ana to St. Louis on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Santa Ana to St. Louis?

momondo provides multiple filters to help you find the best flight to St. Louis from Santa Ana. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Santa Ana to St. Louis right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Santa Ana to St. Louis flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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