Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Santa Ana, California to St. Louis from $162

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Santa Ana, California to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
11:46 am - 10:20 amSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
20h 34m1 stop Denver Intl
Frontier Logo
5:59 pm - 3:02 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
23h 03m1 stop Las Vegas Harry Reid Intl
$301Frontier
Thu, Feb 25 - Sun, Feb 28
Multiple Airlines Logo
11:23 am - 10:20 amSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
20h 57m1 stop Denver Intl
Multiple Airlines Logo
7:02 pm - 3:03 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
22h 01m2 stops Denver Intl Las Vegas Harry Reid Intl
$354Multiple Airlines
Fri, Jan 22 - Mon, Jan 25
American Airlines Logo
8:54 am - 6:49 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
7h 55m1 stop Chicago O'Hare Intl
American Airlines Logo
10:25 am - 3:48 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
7h 23m1 stop Dallas/Fort Worth
$423American Airlines
Wed, Dec 2 - Tue, Dec 8
Delta Logo
1:41 pm - 9:28 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
5h 47m1 stop Salt Lake City
Delta Logo
7:08 am - 12:00 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
6h 52m1 stop Salt Lake City
$423Delta
Sat, Dec 5 - Sat, Dec 12
Southwest Logo
4:10 pm - 11:10 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
5h 00m1 stop Las Vegas Harry Reid Intl
Southwest Logo
8:25 am - 2:45 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
8h 20m2 stops Omaha Eppley Airfield Phoenix Sky Harbor Intl
$428Southwest
Wed, Dec 2 - Tue, Dec 8
Delta Logo
1:41 pm - 9:28 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
5h 47m1 stop Salt Lake City
Delta Logo
5:00 pm - 10:21 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
7h 21m1 stop Salt Lake City
$433Delta
Sat, Dec 5 - Sat, Dec 12
American Airlines Logo
11:35 am - 8:29 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
6h 54m1 stop Chicago O'Hare Intl
American Airlines Logo
2:30 pm - 6:57 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
6h 27m1 stop Phoenix Sky Harbor Intl
$438American Airlines
Tue, Jan 12 - Thu, Jan 14
Southwest Logo
6:45 am - 4:30 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
7h 45m2 stops Phoenix Sky Harbor Intl Las Vegas Harry Reid Intl
Southwest Logo
7:05 am - 1:25 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
8h 20m2 stops Dallas Love Field Las Vegas Harry Reid Intl
$448Southwest
Tue, Jan 12 - Thu, Jan 14
United Airlines Logo
11:06 am - 11:20 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
10h 14m2 stops Denver Intl Chicago O'Hare Intl
United Airlines Logo
3:10 pm - 7:03 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
5h 53m1 stop Denver Intl
$458United Airlines
Sat, Jan 23 - Mon, Jan 25
United Airlines Logo
12:04 pm - 10:30 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
8h 26m1 stop Houston George Bush Intcntl
United Airlines Logo
6:15 am - 11:30 amSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
7h 15m1 stop Houston George Bush Intcntl
$488United Airlines
Fri, Jan 22 - Mon, Jan 25

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Alaska Airlines flights from Santa Ana, California to St. Louis

Our best Alaska Airlines deals on Santa Ana, California to St. Louis flight tickets
Alaska Airlines
Dec 3
SNA12:56 pmSanta Ana J. Wayne/Orange Cnty
9h 03m
1 stop
STL11:59 pmLambert-St Louis
Dec 7
STL6:04 amLambert-St Louis
9h 38m
1 stop
SNA1:42 pmSanta Ana J. Wayne/Orange Cnty
$453
Alaska Airlines
Dec 5
SNA6:45 amSanta Ana J. Wayne/Orange Cnty
7h 55m
1 stop
STL4:40 pmLambert-St Louis
Dec 12
STL6:04 amLambert-St Louis
9h 38m
1 stop
SNA1:42 pmSanta Ana J. Wayne/Orange Cnty
$483
Alaska Airlines
Dec 12
SNA6:45 amSanta Ana J. Wayne/Orange Cnty
7h 55m
1 stop
STL4:40 pmLambert-St Louis
Dec 17
STL6:00 amLambert-St Louis
11h 08m
1 stop
SNA3:08 pmSanta Ana J. Wayne/Orange Cnty
$485

Frontier flights from Santa Ana, California to St. Louis

Our best Frontier deals on Santa Ana, California to St. Louis flight tickets
Frontier
Feb 25
SNA11:46 amSanta Ana J. Wayne/Orange Cnty
20h 34m
1 stop
STL10:20 amLambert-St Louis
Feb 28
STL5:59 pmLambert-St Louis
23h 03m
1 stop
SNA3:02 pmSanta Ana J. Wayne/Orange Cnty
$301
Frontier
Dec 11
SNA12:33 pmSanta Ana J. Wayne/Orange Cnty
20h 24m
1 stop
STL10:57 amLambert-St Louis
Dec 13
STL2:27 pmLambert-St Louis
20h 55m
2 stops
SNA9:22 amSanta Ana J. Wayne/Orange Cnty
$358
Frontier
Dec 18
SNA12:35 pmSanta Ana J. Wayne/Orange Cnty
27h 33m
1 stop
STL6:08 pmLambert-St Louis
Dec 20
STL5:37 pmLambert-St Louis
26h 56m
1 stop
SNA6:33 pmSanta Ana J. Wayne/Orange Cnty
$382

momondo Fare Finder

 
Use the filters below to find and compare flights from Santa Ana, California to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 2/25

11:46 am-10:20 am

1 stop20h 34m

Lambert-St Louis

Sun 2/28

5:59 pm-3:02 pm

1 stop23h 03m

$301

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Fri 1/22

11:23 am-10:20 am

1 stop20h 57m

Lambert-St Louis

Mon 1/25

7:02 pm-3:03 pm

2 stops22h 01m

$354

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Wed 12/2

8:54 am-6:49 pm

1 stop7h 55m

Lambert-St Louis

Tue 12/8

10:25 am-3:48 pm

1 stop7h 23m

$423
Quickest round-trip

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Sat 12/5

1:41 pm-9:28 pm

1 stop5h 47m

Lambert-St Louis

Sat 12/12

7:08 am-12:00 pm

1 stop6h 52m

$423

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Wed 12/2

4:10 pm-11:10 pm

1 stop5h 00m

Lambert-St Louis

Tue 12/8

8:25 am-2:45 pm

2 stops8h 20m

$428

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Sat 12/5

1:41 pm-9:28 pm

1 stop5h 47m

Lambert-St Louis

Sat 12/12

5:00 pm-10:21 pm

1 stop7h 21m

$433

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Tue 1/12

11:35 am-8:29 pm

1 stop6h 54m

Lambert-St Louis

Thu 1/14

2:30 pm-6:57 pm

1 stop6h 27m

$438

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Tue 1/12

6:45 am-4:30 pm

2 stops7h 45m

Lambert-St Louis

Thu 1/14

7:05 am-1:25 pm

2 stops8h 20m

$448

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Sat 1/23

11:06 am-11:20 pm

2 stops10h 14m

Lambert-St Louis

Mon 1/25

3:10 pm-7:03 pm

1 stop5h 53m

$458

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Fri 1/22

12:04 pm-10:30 pm

1 stop8h 26m

Lambert-St Louis

Mon 1/25

6:15 am-11:30 am

1 stop7h 15m

$488

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to St. Louis from

How to get the cheapest flight ticket from Santa Ana, California to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santa Ana, California and St. Louis?

Prices are currently low for flights on this route.

Typical prices usually range from $497 to $827.
The lowest price recently found on this route was $301.

What is the cheapest month to fly to St. Louis?

In general, October is the cheapest month to fly from Santa Ana, California to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $456. The month of September is another great option to travel to St. Louis, with average flight prices from Santa Ana, California averaging around $474.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Wednesday when prices can be found for as low as $436. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $648. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Santa Ana, California in the evening is the least expensive time of day to depart. momondo users have found prices as low as $424 when looking at flights departing in the evening. At noon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $597 per ticket.

How have Santa Ana, California to St. Louis flight prices changed over time?

As of November 2026, prices for Santa Ana, California to St. Louis flights are approximately 1% more expensive when compared to flights at the same time last year.

When to book flights from Santa Ana, California to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana, California to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana, California to St. Louis (SNA to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana, California to St. Louis

Best Price Found

$162

Fastest flight time

5h 10m

Direct flights

None
The best one-way flight to St. Louis from Santa Ana, California in the past 72 hours is $162. The best round-trip flight deal from Santa Ana, California to St. Louis found on momondo in the last 72 hours is $301.
The fastest flight from Santa Ana, California to St. Louis takes 5h 10m
There are no direct flights from Santa Ana, California to St. Louis. There are no popular flight routes from Santa Ana, California to St. Louis.
Search flight deals

Frequently asked questions about flying from Santa Ana, California to St. Louis

  • How far is Santa Ana J. Wayne/Orange Cnty to Lambert-St Louis by plane?

    The straight-line distance from Santa Ana J. Wayne/Orange Cnty to Lambert-St Louis is 1572.0 mi. By plane, this route typically takes 5h 10m.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents required for your trip to Lambert-St Louis Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Lambert-St Louis Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Santa Ana, California to St. Louis?

Best airlines flying from Santa Ana, California to St. Louis

Compare and see reviews for airlines that fly from Santa Ana, California to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $276Free CancellationRating
7.8
8,708 reviews
Search Delta flights
American AirlinesPriceFrom $328Free CancellationRating
7.0
12,224 reviews
Search American Airlines flights
United AirlinesPriceFrom $356Free CancellationRating
7.3
10,474 reviews
Search United Airlines flights
SouthwestPriceFrom $361Free CancellationRating
8.0
4,216 reviews
Search Southwest flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Fairview Heights
Maryland Heights
St. Peters
Alton
Collinsville
Farmington
Florissant
Festus
Clayton
Hermann
Fenton
Edwardsville
O'Fallon
Eureka
Wentzville
Litchfield
Waterloo
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santa Ana to St. Louis for you.

Can I find flights from Santa Ana to St. Louis with flexible booking policies on momondo?

All flight searches from Santa Ana to St. Louis on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Santa Ana to St. Louis?

momondo provides multiple filters to help you find the best flight to St. Louis from Santa Ana. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Santa Ana to St. Louis right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Santa Ana to St. Louis flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your St. Louis trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Fri 12/11
Fri 12/18
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States