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Cheap flights from Santa Ana to St. Louis from $88

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana to St. Louis departing on 4/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Santa Ana to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:45 am - 6:50 am
SNA
-
STL
22h 05m
2 stops
Multiple Airlines Logo
8:12 pm - 10:46 am
STL
-
SNA
16h 34m
1 stop
$204Multiple Airlines
Tue, May 5 - Sat, May 9
Frontier Logo
1:12 pm - 12:15 pm
SNA
-
STL
21h 03m
1 stop
Frontier Logo
8:12 pm - 8:55 am
STL
-
SNA
38h 43m
2 stops
$213Frontier
Mon, Mar 16 - Mon, Mar 23
Multiple Airlines Logo
7:45 am - 9:00 pm
SNA
-
STL
11h 15m
1 stop
Multiple Airlines Logo
9:55 pm - 12:28 pm
STL
-
SNA
16h 33m
1 stop
$219Multiple Airlines
Thu, May 7 - Fri, May 8
Multiple Airlines Logo
6:45 am - 9:00 pm
SNA
-
STL
12h 15m
1 stop
Multiple Airlines Logo
9:55 pm - 8:56 pm
STL
-
SNA
25h 01m
1 stop
$223Multiple Airlines
Thu, Apr 16 - Mon, Apr 20
Multiple Airlines Logo
1:12 pm - 11:19 am
SNA
-
STL
20h 07m
1 stop
Multiple Airlines Logo
8:12 pm - 9:13 pm
STL
-
SNA
27h 01m
2 stops
$225Multiple Airlines
Mon, Mar 23 - Mon, Mar 30
Multiple Airlines Logo
8:59 pm - 3:21 pm
SNA
-
STL
16h 22m
1 stop
Multiple Airlines Logo
9:55 pm - 8:56 pm
STL
-
SNA
25h 01m
1 stop
$226Multiple Airlines
Fri, Apr 17 - Mon, Apr 20
Frontier Logo
8:59 pm - 3:21 pm
SNA
-
STL
16h 22m
1 stop
Frontier Logo
9:55 pm - 5:26 pm
STL
-
SNA
21h 31m
1 stop
$232Frontier
Fri, Apr 17 - Sun, Apr 19
Multiple Airlines Logo
2:53 pm - 11:19 pm
SNA
-
STL
30h 26m
2 stops
Multiple Airlines Logo
8:06 pm - 10:44 am
STL
-
SNA
16h 38m
1 stop
$238Multiple Airlines
Mon, Apr 13 - Thu, Apr 16
Multiple Airlines Logo
2:53 pm - 12:15 pm
SNA
-
STL
19h 22m
1 stop
Multiple Airlines Logo
8:12 pm - 8:55 am
STL
-
SNA
38h 43m
2 stops
$242Multiple Airlines
Mon, Mar 16 - Mon, Mar 23
Multiple Airlines Logo
7:45 am - 9:00 pm
SNA
-
STL
11h 15m
1 stop
Multiple Airlines Logo
8:12 pm - 1:44 pm
STL
-
SNA
19h 32m
2 stops
$244Multiple Airlines
Thu, May 7 - Fri, May 8

United Airlines flights from Santa Ana to St. Louis

Our best United Airlines deals on Santa Ana to St. Louis flight tickets
United Airlines
May 5
SNA1:22 pmSanta Ana J. Wayne/Orange Cnty
5h 21m
1 stop
STL8:43 pmLambert-St Louis
May 9
STL6:00 amLambert-St Louis
7h 11m
1 stop
SNA11:11 amSanta Ana J. Wayne/Orange Cnty
$277
United Airlines
May 5
SNA11:00 amSanta Ana J. Wayne/Orange Cnty
8h 08m
2 stops
STL9:08 pmLambert-St Louis
May 9
STL6:00 amLambert-St Louis
9h 36m
1 stop
SNA1:36 pmSanta Ana J. Wayne/Orange Cnty
$372
United Airlines
May 5
SNA6:39 pmSanta Ana J. Wayne/Orange Cnty
12h 00m
2 stops
STL8:39 amLambert-St Louis
May 9
STL9:00 amLambert-St Louis
13h 44m
2 stops
SNA8:44 pmSanta Ana J. Wayne/Orange Cnty
$378

Delta flights from Santa Ana to St. Louis

Our best Delta deals on Santa Ana to St. Louis flight tickets
Delta
Apr 8
SNA7:05 amSanta Ana J. Wayne/Orange Cnty
8h 02m
1 stop
STL5:07 pmLambert-St Louis
Apr 9
STL2:12 pmLambert-St Louis
5h 58m
1 stop
SNA6:10 pmSanta Ana J. Wayne/Orange Cnty
$318
Delta
Apr 17
SNA11:54 amSanta Ana J. Wayne/Orange Cnty
7h 25m
1 stop
STL9:19 pmLambert-St Louis
Apr 20
STL2:20 pmLambert-St Louis
10h 08m
2 stops
SNA10:28 pmSanta Ana J. Wayne/Orange Cnty
$346
Delta
Mar 30
SNA1:43 pmSanta Ana J. Wayne/Orange Cnty
8h 38m
1 stop
STL12:21 amLambert-St Louis
Apr 1
STL7:15 amLambert-St Louis
7h 05m
1 stop
SNA12:20 pmSanta Ana J. Wayne/Orange Cnty
$381

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 26, 2026.
Use the filters below to find and compare flights from Santa Ana to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Tue 5/5

6:45 am-6:50 am

2 stops22h 05m

Lambert-St Louis

Sat 5/9

8:12 pm-10:46 am

1 stop16h 34m

$204

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Mon 3/16

1:12 pm-12:15 pm

1 stop21h 03m

Lambert-St Louis

Mon 3/23

8:12 pm-8:55 am

2 stops38h 43m

$213

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 5/7

7:45 am-9:00 pm

1 stop11h 15m

Lambert-St Louis

Fri 5/8

9:55 pm-12:28 pm

1 stop16h 33m

$219

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 4/16

6:45 am-9:00 pm

1 stop12h 15m

Lambert-St Louis

Mon 4/20

9:55 pm-8:56 pm

1 stop25h 01m

$223

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Mon 3/23

1:12 pm-11:19 am

1 stop20h 07m

Lambert-St Louis

Mon 3/30

8:12 pm-9:13 pm

2 stops27h 01m

$225

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Fri 4/17

8:59 pm-3:21 pm

1 stop16h 22m

Lambert-St Louis

Mon 4/20

9:55 pm-8:56 pm

1 stop25h 01m

$226

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Fri 4/17

8:59 pm-3:21 pm

1 stop16h 22m

Lambert-St Louis

Sun 4/19

9:55 pm-5:26 pm

1 stop21h 31m

$232

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Mon 4/13

2:53 pm-11:19 pm

2 stops30h 26m

Lambert-St Louis

Thu 4/16

8:06 pm-10:44 am

1 stop16h 38m

$238

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Mon 3/16

2:53 pm-12:15 pm

1 stop19h 22m

Lambert-St Louis

Mon 3/23

8:12 pm-8:55 am

2 stops38h 43m

$242

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 5/7

7:45 am-9:00 pm

1 stop11h 15m

Lambert-St Louis

Fri 5/8

8:12 pm-1:44 pm

2 stops19h 32m

$244

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Santa Ana to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, October is the cheapest month to fly from Santa Ana to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $326. The month of August is another great option to travel to St. Louis, with average flight prices from Santa Ana averaging around $331.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Wednesday when prices can be found for as low as $384. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $447. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Santa Ana in the evening is the least expensive time of day to depart. momondo users have found prices as low as $351 when looking at flights departing in the evening. At noon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $425 per ticket.

How have Santa Ana to St. Louis flight prices changed over time?

As of February 2026, prices for Santa Ana to St. Louis flights are approximately 4% more expensive when compared to flights at the same time last year.

When to book flights from Santa Ana to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana to St. Louis (SNA to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana to St. Louis

Fastest flight time

5h 20m

Direct flights

None
The fastest flight from Santa Ana to St. Louis takes 5h 20m
There are no direct flights from Santa Ana to St. Louis. There are no popular flight routes from Santa Ana to St. Louis.
Search flight deals

  • How far is Santa Ana J. Wayne/Orange Cnty to Lambert-St Louis by plane?

    The straight-line distance from Santa Ana J. Wayne/Orange Cnty to Lambert-St Louis is 1572.0 mi. By plane, this route typically takes 5h 20m.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents required for your trip to Lambert-St Louis Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Lambert-St Louis Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Santa Ana to St. Louis?

Best airlines flying from Santa Ana to St. Louis

Compare and see reviews for airlines that fly from Santa Ana to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $150Free CancellationRating
5.7
3,041 reviews
Search Frontier flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,242 reviews
Search Delta flights
American AirlinesPriceFrom $278Free CancellationRating
7.2
11,357 reviews
Search American Airlines flights
SouthwestPriceFrom $302Free CancellationRating
8.0
4,301 reviews
Search Southwest flights
United AirlinesPriceFrom $311Free CancellationRating
7.4
9,349 reviews
Search United Airlines flights

  • United Airlines Flights From Santa Ana to St. Louis

    United Airlines flies from Santa Ana to St. Louis around 6 times per week, with 9,349 momondo users rating the airline 7.4/10. The cheapest United Airlines deal from Santa Ana to St. Louis in the last 72 hours was $311 (round-trip), much lower than the average airfare cost of $436 for United Airlines flights on this route.

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Florissant
Maryland Heights
O'Fallon
St. Peters
Wentzville
Collinsville
Fenton
Alton
Farmington
Clayton
Edwardsville
Festus
Eureka
Litchfield
Glencoe
Grafton

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santa Ana to St. Louis for you.

Can I find flights from Santa Ana to St. Louis with flexible booking policies on momondo?

All flight searches from Santa Ana to St. Louis on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Santa Ana to St. Louis?

momondo provides multiple filters to help you find the best flight to St. Louis from Santa Ana. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Santa Ana to St. Louis right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Santa Ana to St. Louis flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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