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Cheap flights from Santa Ana, California to St. Louis from $78

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana, California to St. Louis departing on 11/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Santa Ana, California to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
4:50 pm - 1:17 amSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
6h 27m1 stop Las Vegas Harry Reid Intl
Frontier Logo
8:10 pm - 10:12 amSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
16h 02m1 stop Denver Intl
$231Frontier
Thu, Oct 22 - Fri, Oct 23
Frontier Logo
4:35 pm - 11:17 amSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
16h 42m1 stop Las Vegas Harry Reid Intl
Frontier Logo
12:17 pm - 5:15 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
6h 58m1 stop Las Vegas Harry Reid Intl
$234Frontier
Thu, Sep 10 - Mon, Sep 14
Multiple Airlines Logo
7:28 pm - 5:54 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
20h 26m1 stop Dallas/Fort Worth
Multiple Airlines Logo
5:32 pm - 3:03 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
23h 31m1 stop Las Vegas Harry Reid Intl
$250Multiple Airlines
Thu, Oct 29 - Mon, Nov 2
Multiple Airlines Logo
7:30 am - 5:50 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
8h 20m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
12:17 pm - 5:15 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
6h 58m1 stop Las Vegas Harry Reid Intl
$262Multiple Airlines
Tue, Sep 1 - Mon, Sep 21
American Airlines Logo
3:11 pm - 12:27 amSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
7h 16m1 stop Chicago O'Hare Intl
American Airlines Logo
5:43 am - 9:45 amSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
6h 02m1 stop Dallas/Fort Worth
$329American Airlines
Mon, Sep 28 - Wed, Sep 30
American Airlines Logo
3:30 pm - 12:19 amSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
6h 49m1 stop Chicago O'Hare Intl
American Airlines Logo
12:46 pm - 5:42 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
6h 56m1 stop Dallas/Fort Worth
$329American Airlines
Mon, Oct 12 - Sat, Oct 17
Southwest Logo
11:05 am - 9:20 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
8h 15m1 stop Denver Intl
Southwest Logo
8:25 am - 4:00 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
9h 35m2 stops Omaha Eppley Airfield Phoenix Sky Harbor Intl
$334Southwest
Tue, Oct 20 - Sat, Oct 24
Southwest Logo
2:40 pm - 10:50 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
6h 10m1 stop Las Vegas Harry Reid Intl
Southwest Logo
8:25 am - 4:00 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
9h 35m2 stops Omaha Eppley Airfield Phoenix Sky Harbor Intl
$336Southwest
Sat, Oct 10 - Sat, Oct 17
Delta Logo
8:11 am - 4:44 pmSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
6h 33m1 stop Minneapolis St Paul
Delta Logo
8:00 am - 12:05 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
6h 05m1 stop Salt Lake City
$353Delta
Sat, Sep 5 - Sun, Sep 6
Delta Logo
4:58 pm - 12:44 amSNA  Santa Ana J. Wayne/Orange Cnty-STL Lambert-St Louis
5h 46m1 stop Salt Lake City
Delta Logo
5:00 pm - 10:04 pmSTL  Lambert-St Louis-SNA Santa Ana J. Wayne/Orange Cnty
7h 04m1 stop Salt Lake City
$385Delta
Fri, Sep 25 - Sat, Sep 26

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Frontier flights from Santa Ana, California to St. Louis

Our best Frontier deals on Santa Ana, California to St. Louis flight tickets
Frontier
Oct 22
SNA4:50 pmSanta Ana J. Wayne/Orange Cnty
6h 27m
1 stop
STL1:17 amLambert-St Louis
Oct 23
STL8:10 pmLambert-St Louis
16h 02m
1 stop
SNA10:12 amSanta Ana J. Wayne/Orange Cnty
$231
Frontier
Sep 10
SNA4:35 pmSanta Ana J. Wayne/Orange Cnty
16h 42m
1 stop
STL11:17 amLambert-St Louis
Sep 14
STL12:17 pmLambert-St Louis
6h 58m
1 stop
SNA5:15 pmSanta Ana J. Wayne/Orange Cnty
$234
Frontier
Oct 23
SNA2:53 pmSanta Ana J. Wayne/Orange Cnty
26h 04m
2 stops
STL6:57 pmLambert-St Louis
Nov 1
STL8:10 pmLambert-St Louis
16h 01m
1 stop
SNA10:11 amSanta Ana J. Wayne/Orange Cnty
$238

American Airlines flights from Santa Ana, California to St. Louis

Our best American Airlines deals on Santa Ana, California to St. Louis flight tickets
American Airlines
Sep 10
SNA1:40 pmSanta Ana J. Wayne/Orange Cnty
6h 17m
1 stop
STL9:57 pmLambert-St Louis
Sep 15
STL5:43 amLambert-St Louis
7h 07m
1 stop
SNA10:50 amSanta Ana J. Wayne/Orange Cnty
$329
American Airlines
Sep 10
SNA1:40 pmSanta Ana J. Wayne/Orange Cnty
6h 17m
1 stop
STL9:57 pmLambert-St Louis
Sep 15
STL5:43 amLambert-St Louis
7h 07m
1 stop
SNA10:50 amSanta Ana J. Wayne/Orange Cnty
$330
American Airlines
Sep 3
SNA2:29 pmSanta Ana J. Wayne/Orange Cnty
7h 13m
1 stop
STL11:42 pmLambert-St Louis
Sep 7
STL6:36 amLambert-St Louis
6h 14m
1 stop
SNA10:50 amSanta Ana J. Wayne/Orange Cnty
$343

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana, California to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 14, 2026.
Use the filters below to find and compare flights from Santa Ana, California to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 10/22

4:50 pm-1:17 am

1 stop6h 27m

Lambert-St Louis

Fri 10/23

8:10 pm-10:12 am

1 stop16h 02m

$231

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 9/10

4:35 pm-11:17 am

1 stop16h 42m

Lambert-St Louis

Mon 9/14

12:17 pm-5:15 pm

1 stop6h 58m

$234

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 10/29

7:28 pm-5:54 pm

1 stop20h 26m

Lambert-St Louis

Mon 11/2

5:32 pm-3:03 pm

1 stop23h 31m

$250

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Tue 9/1

7:30 am-5:50 pm

1 stop8h 20m

Lambert-St Louis

Mon 9/21

12:17 pm-5:15 pm

1 stop6h 58m

$262

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Mon 9/28

3:11 pm-12:27 am

1 stop7h 16m

Lambert-St Louis

Wed 9/30

5:43 am-9:45 am

1 stop6h 02m

$329

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Mon 10/12

3:30 pm-12:19 am

1 stop6h 49m

Lambert-St Louis

Sat 10/17

12:46 pm-5:42 pm

1 stop6h 56m

$329

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Tue 10/20

11:05 am-9:20 pm

1 stop8h 15m

Lambert-St Louis

Sat 10/24

8:25 am-4:00 pm

2 stops9h 35m

$334

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Sat 10/10

2:40 pm-10:50 pm

1 stop6h 10m

Lambert-St Louis

Sat 10/17

8:25 am-4:00 pm

2 stops9h 35m

$336
Quickest round-trip

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Sat 9/5

8:11 am-4:44 pm

1 stop6h 33m

Lambert-St Louis

Sun 9/6

8:00 am-12:05 pm

1 stop6h 05m

$353

Santa AnaSt. Louis

SNA Santa Ana J. Wayne/Orange Cnty - STL Lambert-St Louis

SNASTL

Santa Ana J. Wayne/Orange Cnty

Fri 9/25

4:58 pm-12:44 am

1 stop5h 46m

Lambert-St Louis

Sat 9/26

5:00 pm-10:04 pm

1 stop7h 04m

$385

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Santa Ana, California to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santa Ana, California and St. Louis?

Prices are currently low for flights on this route.

Typical prices usually range from $473 to $689.
The lowest price recently found on this route was $231.

What is the cheapest month to fly to St. Louis?

In general, October is the cheapest month to fly from Santa Ana, California to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $332. The month of February is another great option to travel to St. Louis, with average flight prices from Santa Ana, California averaging around $422.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Thursday when prices can be found for as low as $419. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $571. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Santa Ana, California in the evening is the least expensive time of day to depart. momondo users have found prices as low as $331 when looking at flights departing in the evening. At noon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $570 per ticket.

How have Santa Ana, California to St. Louis flight prices changed over time?

As of August 2026, prices for Santa Ana, California to St. Louis flights are approximately 165% more expensive when compared to flights at the same time last year.

When to book flights from Santa Ana, California to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana, California to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana, California to St. Louis (SNA to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana, California to St. Louis

Fastest flight time

5h 10m

Direct flights

None
The fastest flight from Santa Ana, California to St. Louis takes 5h 10m
There are no direct flights from Santa Ana, California to St. Louis. There are no popular flight routes from Santa Ana, California to St. Louis.
Search flight deals

Frequently asked questions about flying from Santa Ana, California to St. Louis

  • How far is Santa Ana J. Wayne/Orange Cnty to Lambert-St Louis by plane?

    The straight-line distance from Santa Ana J. Wayne/Orange Cnty to Lambert-St Louis is 1572.0 mi. By plane, this route typically takes 5h 10m.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents required for your trip to Lambert-St Louis Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Lambert-St Louis Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Santa Ana, California to St. Louis?

Best airlines flying from Santa Ana, California to St. Louis

Compare and see reviews for airlines that fly from Santa Ana, California to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $129Free CancellationRating
5.6
2,694 reviews
Search Frontier flights
DeltaPriceFrom $276Free CancellationRating
7.8
8,510 reviews
Search Delta flights
United AirlinesPriceFrom $311Free CancellationRating
7.4
10,109 reviews
Search United Airlines flights
SouthwestPriceFrom $316Free CancellationRating
8.0
4,218 reviews
Search Southwest flights
American AirlinesPriceFrom $317Free CancellationRating
7.1
11,933 reviews
Search American Airlines flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Fairview Heights
Hermann
St. Peters
Maryland Heights
Collinsville
Florissant
Alton
O'Fallon
Farmington
Clayton
Fenton
Festus
Wentzville
Eureka
Edwardsville
Litchfield
Grafton
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santa Ana to St. Louis for you.

Can I find flights from Santa Ana to St. Louis with flexible booking policies on momondo?

All flight searches from Santa Ana to St. Louis on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Santa Ana to St. Louis?

momondo provides multiple filters to help you find the best flight to St. Louis from Santa Ana. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Santa Ana to St. Louis right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Santa Ana to St. Louis flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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