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Cheap flights from Santa Ana to Knoxville from $125

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana to Knoxville departing on 9/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Santa Ana to Knoxville

Cheap round-trip flights

Frontier Logo
12:18 pm - 7:50 pmSNA-TYS
28h 32m1 stop
Frontier Logo
5:08 pm - 11:07 amTYS-SNA
20h 59m1 stop
$208Frontier
Find Deal
Wed, Sep 3 - Sun, Sep 7
Logo
12:58 pm - 1:43 pmSNA-TYS
21h 45m1 stop
Logo
7:35 pm - 10:05 pmTYS-SNA
29h 30m2 stops
$228
Find Deal
Wed, Sep 24 - Sun, Sep 28
Logo
12:58 pm - 1:43 pmSNA-TYS
21h 45m1 stop
Logo
4:50 pm - 12:05 pmTYS-SNA
22h 15m1 stop
$245
Find Deal
Wed, Sep 24 - Sun, Sep 28
Logo
2:20 pm - 1:44 pmSNA-TYS
20h 24m1 stop
Logo
8:00 am - 4:51 pmTYS-SNA
11h 51m1 stop
$246
Find Deal
Sat, Nov 8 - Mon, Nov 10
Logo
7:16 pm - 10:30 pmSNA-TYS
24h 14m1 stop
Logo
8:30 am - 10:05 pmTYS-SNA
16h 35m1 stop
$258
Find Deal
Thu, Sep 4 - Mon, Sep 8
Delta Logo
1:52 pm - 11:44 pmSNA-TYS
6h 52m1 stop
Delta Logo
5:45 am - 11:03 amTYS-SNA
8h 18m1 stop
$289Delta
Find Deal
Wed, Sep 24 - Sat, Sep 27
Delta Logo
1:52 pm - 11:44 pmSNA-TYS
6h 52m1 stop
Delta Logo
5:45 am - 11:48 amTYS-SNA
9h 03m2 stops
$294Delta
Find Deal
Wed, Sep 24 - Sat, Sep 27
American Airlines Logo
10:28 am - 11:03 pmSNA-TYS
9h 35m2 stops
American Airlines Logo
8:23 am - 3:45 pmTYS-SNA
10h 22m2 stops
$299American Airlines
Find Deal
Wed, Sep 17 - Tue, Sep 23
American Airlines Logo
10:28 am - 11:03 pmSNA-TYS
9h 35m2 stops
American Airlines Logo
6:00 am - 12:00 pmTYS-SNA
9h 00m2 stops
$343American Airlines
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Wed, Sep 24 - Sat, Sep 27
United Airlines Logo
7:00 pm - 9:58 amSNA-TYS
11h 58m2 stops
United Airlines Logo
7:00 am - 4:56 pmTYS-SNA
12h 56m2 stops
$389United Airlines
Find Deal
Fri, Sep 12 - Tue, Sep 16

American Airlines flights from Santa Ana to Knoxville

Our best American Airlines deals on Santa Ana to Knoxville flight tickets
American Airlines
Sep 17
SNA10:28 amSanta Ana J. Wayne/Orange Cnty
9h 35m
2 stops
TYS11:03 pmKnoxville McGhee Tyson
Sep 23
TYS8:23 amKnoxville McGhee Tyson
10h 22m
2 stops
SNA3:45 pmSanta Ana J. Wayne/Orange Cnty
$299
Find similar
American Airlines
Sep 24
SNA10:28 amSanta Ana J. Wayne/Orange Cnty
9h 35m
2 stops
TYS11:03 pmKnoxville McGhee Tyson
Sep 27
TYS6:00 amKnoxville McGhee Tyson
9h 00m
2 stops
SNA12:00 pmSanta Ana J. Wayne/Orange Cnty
$343
Find similar
American Airlines
Sep 24
SNA10:00 amSanta Ana J. Wayne/Orange Cnty
10h 03m
2 stops
TYS11:03 pmKnoxville McGhee Tyson
Sep 27
TYS6:00 amKnoxville McGhee Tyson
9h 00m
2 stops
SNA12:00 pmSanta Ana J. Wayne/Orange Cnty
$349
Find similar

Delta flights from Santa Ana to Knoxville

Our best Delta deals on Santa Ana to Knoxville flight tickets
Delta
Sep 24
SNA1:52 pmSanta Ana J. Wayne/Orange Cnty
6h 52m
1 stop
TYS11:44 pmKnoxville McGhee Tyson
Sep 27
TYS5:45 amKnoxville McGhee Tyson
8h 18m
1 stop
SNA11:03 amSanta Ana J. Wayne/Orange Cnty
$289
Find similar
Delta
Sep 24
SNA1:52 pmSanta Ana J. Wayne/Orange Cnty
6h 52m
1 stop
TYS11:44 pmKnoxville McGhee Tyson
Sep 27
TYS5:45 amKnoxville McGhee Tyson
9h 03m
2 stops
SNA11:48 amSanta Ana J. Wayne/Orange Cnty
$294
Find similar
Delta
Oct 20
SNA9:20 pmSanta Ana J. Wayne/Orange Cnty
9h 00m
1 stop
TYS9:20 amKnoxville McGhee Tyson
Oct 25
TYS11:33 amKnoxville McGhee Tyson
11h 35m
2 stops
SNA8:08 pmSanta Ana J. Wayne/Orange Cnty
$319
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 21, 2025.
Use the filters below to find and compare flights from Santa Ana to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 9/3

12:18 pm-7:50 pm

1 stop28h 32m

Knoxville McGhee Tyson

Sun 9/7

5:08 pm-11:07 am

1 stop20h 59m

$208

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 9/24

12:58 pm-1:43 pm

1 stop21h 45m

Knoxville McGhee Tyson

Sun 9/28

7:35 pm-10:05 pm

2 stops29h 30m

$228

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 9/24

12:58 pm-1:43 pm

1 stop21h 45m

Knoxville McGhee Tyson

Sun 9/28

4:50 pm-12:05 pm

1 stop22h 15m

$245

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sat 11/8

2:20 pm-1:44 pm

1 stop20h 24m

Knoxville McGhee Tyson

Mon 11/10

8:00 am-4:51 pm

1 stop11h 51m

$246

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 9/4

7:16 pm-10:30 pm

1 stop24h 14m

Knoxville McGhee Tyson

Mon 9/8

8:30 am-10:05 pm

1 stop16h 35m

$258

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 9/24

1:52 pm-11:44 pm

1 stop6h 52m

Knoxville McGhee Tyson

Sat 9/27

5:45 am-11:03 am

1 stop8h 18m

$289

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 9/24

1:52 pm-11:44 pm

1 stop6h 52m

Knoxville McGhee Tyson

Sat 9/27

5:45 am-11:48 am

2 stops9h 03m

$294

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 9/17

10:28 am-11:03 pm

2 stops9h 35m

Knoxville McGhee Tyson

Tue 9/23

8:23 am-3:45 pm

2 stops10h 22m

$299

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 9/24

10:28 am-11:03 pm

2 stops9h 35m

Knoxville McGhee Tyson

Sat 9/27

6:00 am-12:00 pm

2 stops9h 00m

$343

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Fri 9/12

7:00 pm-9:58 am

2 stops11h 58m

Knoxville McGhee Tyson

Tue 9/16

7:00 am-4:56 pm

2 stops12h 56m

$389

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Santa Ana to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Santa Ana, with most prices found around $338. If you aren’t able to travel during the month of August, then book flights to Knoxville from Santa Ana during January instead. Flights to Knoxville in January, while not as cheap as those in August, still average around $378.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Santa Ana to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $387. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Santa Ana to Knoxville for around $552.

What is the cheapest time of day to depart on your flight to Knoxville?

In the afternoon is the cheapest time of day to fly from Santa Ana to Knoxville when you can find flight prices for as low as $399. Flying to Knoxville in the afternoon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the evening when prices are around $442.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Santa Ana when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $426 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Santa Ana for as low as $302 on momondo.

How have Santa Ana to Knoxville flight prices changed over time?

As of August 2025, prices for Santa Ana to Knoxville flights are approximately 12% more expensive when compared to flights at the same time last year.

When to book flights from Santa Ana to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana to Knoxville (SNA to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana to Knoxville

Direct flights

None
There are no direct flights from Santa Ana to Knoxville. There are no popular flight routes from Santa Ana to Knoxville.
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  • How far is Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson by plane?

    Santa Ana J. Wayne/Orange Cnty and Knoxville McGhee Tyson are 1919.8 mi apart from one another. 6h 49m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santa Ana to Knoxville?

Best airlines flying from Santa Ana to Knoxville

Compare and see reviews for airlines that fly from Santa Ana to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $239Free CancellationRating
7.4
8,930 reviews
Search United Airlines flights
American AirlinesPriceFrom $268Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $276Free CancellationRating
7.9
7,981 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Newport
Lenoir City
Alcoa
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santa Ana to Knoxville for you.

Can I find flights from Santa Ana to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Santa Ana to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Santa Ana to Knoxville?

momondo helps you find the best flight between Santa Ana and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santa Ana to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Santa Ana to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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