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Cheap flights from Santa Ana, California to Knoxville from $169

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana, California to Knoxville departing on 8/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Santa Ana, California to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
3:07 pm - 3:38 pm
SNA
-
TYS
21h 31m
1 stop
Multiple Airlines Logo
4:27 pm - 10:12 am
TYS
-
SNA
20h 45m
1 stop
$311Multiple Airlines
Sun, Oct 18 - Sun, Oct 25
Multiple Airlines Logo
7:30 am - 8:39 pm
SNA
-
TYS
10h 09m
1 stop
Multiple Airlines Logo
4:27 pm - 10:12 am
TYS
-
SNA
20h 45m
1 stop
$322Multiple Airlines
Thu, Oct 22 - Sun, Oct 25
Multiple Airlines Logo
9:33 pm - 3:38 pm
SNA
-
TYS
15h 05m
1 stop
Multiple Airlines Logo
9:29 pm - 5:35 pm
TYS
-
SNA
23h 06m
1 stop
$335Multiple Airlines
Sun, Oct 18 - Thu, Oct 22
Multiple Airlines Logo
3:07 pm - 3:38 pm
SNA
-
TYS
21h 31m
1 stop
Multiple Airlines Logo
12:49 pm - 5:35 pm
TYS
-
SNA
7h 46m
1 stop
$345Multiple Airlines
Sun, Oct 18 - Fri, Oct 23
American Airlines Logo
12:01 pm - 11:18 pm
SNA
-
TYS
8h 17m
1 stop
American Airlines Logo
1:40 pm - 5:33 pm
TYS
-
SNA
6h 53m
1 stop
$349American Airlines
Wed, Oct 21 - Sat, Oct 24
United Airlines Logo
7:59 pm - 9:45 am
SNA
-
TYS
10h 46m
2 stops
United Airlines Logo
7:15 am - 11:02 am
TYS
-
SNA
6h 47m
1 stop
$354United Airlines
Wed, Oct 21 - Sat, Oct 24
Multiple Airlines Logo
7:30 am - 8:39 pm
SNA
-
TYS
10h 09m
1 stop
Multiple Airlines Logo
12:49 pm - 5:35 pm
TYS
-
SNA
7h 46m
1 stop
$356Multiple Airlines
Thu, Oct 22 - Fri, Oct 23
Southwest Logo
6:45 am - 6:30 pm
SNA
-
TYS
8h 45m
2 stops
Southwest Logo
7:00 am - 1:05 pm
TYS
-
SNA
9h 05m
2 stops
$359Southwest
Wed, Oct 21 - Sat, Oct 24
Multiple Airlines Logo
7:30 am - 8:39 pm
SNA
-
TYS
10h 09m
1 stop
Multiple Airlines Logo
12:49 pm - 5:35 pm
TYS
-
SNA
7h 46m
1 stop
$361Multiple Airlines
Thu, Oct 22 - Fri, Oct 23
Delta Logo
12:20 pm - 11:46 pm
SNA
-
TYS
8h 26m
1 stop
Delta Logo
8:47 am - 12:56 pm
TYS
-
SNA
7h 09m
1 stop
$364Delta
Tue, Oct 20 - Sat, Oct 24

American Airlines flights from Santa Ana, California to Knoxville

Our best American Airlines deals on Santa Ana, California to Knoxville flight tickets
American Airlines
Oct 21
SNA12:01 pmSanta Ana J. Wayne/Orange Cnty
8h 17m
1 stop
TYS11:18 pmKnoxville McGhee Tyson
Oct 24
TYS1:40 pmKnoxville McGhee Tyson
6h 53m
1 stop
SNA5:33 pmSanta Ana J. Wayne/Orange Cnty
$349
American Airlines
Sep 9
SNA6:45 amSanta Ana J. Wayne/Orange Cnty
6h 57m
1 stop
TYS4:42 pmKnoxville McGhee Tyson
Sep 13
TYS6:00 amKnoxville McGhee Tyson
6h 45m
1 stop
SNA9:45 amSanta Ana J. Wayne/Orange Cnty
$452
American Airlines
Jun 2
SNA2:30 pmSanta Ana J. Wayne/Orange Cnty
6h 26m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
Jun 3
TYS5:36 amKnoxville McGhee Tyson
8h 20m
1 stop
SNA10:56 amSanta Ana J. Wayne/Orange Cnty
$549

Southwest flights from Santa Ana, California to Knoxville

Our best Southwest deals on Santa Ana, California to Knoxville flight tickets
Southwest
Oct 21
SNA6:45 amSanta Ana J. Wayne/Orange Cnty
8h 45m
2 stops
TYS6:30 pmKnoxville McGhee Tyson
Oct 24
TYS7:00 amKnoxville McGhee Tyson
9h 05m
2 stops
SNA1:05 pmSanta Ana J. Wayne/Orange Cnty
$359
Southwest
Oct 21
SNA6:45 amSanta Ana J. Wayne/Orange Cnty
8h 45m
2 stops
TYS6:30 pmKnoxville McGhee Tyson
Oct 24
TYS2:55 pmKnoxville McGhee Tyson
8h 50m
2 stops
SNA8:45 pmSanta Ana J. Wayne/Orange Cnty
$374
Southwest
Aug 27
SNA8:50 pmSanta Ana J. Wayne/Orange Cnty
13h 35m
2 stops
TYS1:25 pmKnoxville McGhee Tyson
Sep 8
TYS3:00 pmKnoxville McGhee Tyson
8h 55m
1 stop
SNA8:55 pmSanta Ana J. Wayne/Orange Cnty
$375

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana, California to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 28, 2026.
Use the filters below to find and compare flights from Santa Ana, California to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sun 10/18

3:07 pm-3:38 pm

1 stop21h 31m

Knoxville McGhee Tyson

Sun 10/25

4:27 pm-10:12 am

1 stop20h 45m

$311

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 10/22

7:30 am-8:39 pm

1 stop10h 09m

Knoxville McGhee Tyson

Sun 10/25

4:27 pm-10:12 am

1 stop20h 45m

$322

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sun 10/18

9:33 pm-3:38 pm

1 stop15h 05m

Knoxville McGhee Tyson

Thu 10/22

9:29 pm-5:35 pm

1 stop23h 06m

$335

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sun 10/18

3:07 pm-3:38 pm

1 stop21h 31m

Knoxville McGhee Tyson

Fri 10/23

12:49 pm-5:35 pm

1 stop7h 46m

$345
Quickest round-trip

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 10/21

12:01 pm-11:18 pm

1 stop8h 17m

Knoxville McGhee Tyson

Sat 10/24

1:40 pm-5:33 pm

1 stop6h 53m

$349

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 10/21

7:59 pm-9:45 am

2 stops10h 46m

Knoxville McGhee Tyson

Sat 10/24

7:15 am-11:02 am

1 stop6h 47m

$354

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 10/22

7:30 am-8:39 pm

1 stop10h 09m

Knoxville McGhee Tyson

Fri 10/23

12:49 pm-5:35 pm

1 stop7h 46m

$356

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 10/21

6:45 am-6:30 pm

2 stops8h 45m

Knoxville McGhee Tyson

Sat 10/24

7:00 am-1:05 pm

2 stops9h 05m

$359

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 10/22

7:30 am-8:39 pm

1 stop10h 09m

Knoxville McGhee Tyson

Fri 10/23

12:49 pm-5:35 pm

1 stop7h 46m

$361

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Tue 10/20

12:20 pm-11:46 pm

1 stop8h 26m

Knoxville McGhee Tyson

Sat 10/24

8:47 am-12:56 pm

1 stop7h 09m

$364

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Santa Ana, California to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santa Ana, California and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of November is, on average, the cheapest month to fly to Knoxville from Santa Ana, California, with most prices found around $362. If you aren’t able to travel during the month of November, then book flights to Knoxville from Santa Ana, California during August instead. Flights to Knoxville in August, while not as cheap as those in November, still average around $378.

How far in advance should I book a flight from Santa Ana, California to Knoxville?

You are more likely to see cheaper flights to Knoxville from Santa Ana, California when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $467 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Santa Ana, California for as low as $394 on momondo.

Can stopping save me money on Santa Ana, California to Knoxville flights?

You could potentially save up to 15% on your flight if you consider stops on a Santa Ana, California to Knoxville flight.

How have Santa Ana, California to Knoxville flight prices changed over time?

As of May 2026, prices for Santa Ana, California to Knoxville flights are approximately 28% cheaper when compared to flights at the same time last year.

When to book flights from Santa Ana, California to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana, California to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana, California to Knoxville (SNA to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana, California to Knoxville

Fastest flight time

6h 08m

Direct flights

None
The fastest flight from Santa Ana, California to Knoxville takes 6h 08m
There are no direct flights from Santa Ana, California to Knoxville. There are no popular flight routes from Santa Ana, California to Knoxville.
Search flight deals

Frequently asked questions about flying from Santa Ana, California to Knoxville

  • How far is Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson by plane?

    Santa Ana J. Wayne/Orange Cnty and Knoxville McGhee Tyson are 1919.8 mi apart from one another. 6h 08m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santa Ana, California to Knoxville?

Best airlines flying from Santa Ana, California to Knoxville

Compare and see reviews for airlines that fly from Santa Ana, California to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $288Free CancellationRating
7.9
8,423 reviews
Search Delta flights
United AirlinesPriceFrom $288Free CancellationRating
7.4
9,751 reviews
Search United Airlines flights
American AirlinesPriceFrom $288Free CancellationRating
7.1
11,639 reviews
Search American Airlines flights
SouthwestPriceFrom $456Free CancellationRating
7.9
4,264 reviews
Search Southwest flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Lenoir City
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santa Ana to Knoxville for you.

Can I find flights from Santa Ana to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Santa Ana to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Santa Ana to Knoxville?

momondo helps you find the best flight between Santa Ana and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santa Ana to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Santa Ana to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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