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Cheap flights from Santa Ana, California to Knoxville from $219

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana, California to Knoxville departing on 1/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Santa Ana, California to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
3:26 pm - 10:22 pmSNA-TYS
27h 56m1 stop
Multiple Airlines Logo
6:30 am - 10:44 amTYS-SNA
55h 14m2 stops
$271Multiple Airlines
Find Deal
Sat, Dec 6 - Sun, Dec 14
American Airlines Logo
6:45 am - 5:33 pmSNA-TYS
7h 48m1 stop
American Airlines Logo
12:19 pm - 6:27 pmTYS-SNA
9h 08m1 stop
$289American Airlines
Find Deal
Wed, Feb 18 - Sat, Feb 21
American Airlines Logo
7:53 pm - 8:41 amSNA-TYS
9h 48m2 stops
American Airlines Logo
5:35 am - 10:08 amTYS-SNA
7h 33m1 stop
$294American Airlines
Find Deal
Wed, Feb 18 - Sat, Feb 21
American Airlines Logo
7:53 pm - 8:41 amSNA-TYS
9h 48m2 stops
American Airlines Logo
12:19 pm - 7:03 pmTYS-SNA
9h 44m2 stops
$299American Airlines
Find Deal
Wed, Feb 18 - Sat, Feb 21
Multiple Airlines Logo
3:55 pm - 7:23 pmSNA-TYS
24h 28m1 stop
Multiple Airlines Logo
10:00 am - 11:32 amTYS-SNA
28h 32m2 stops
$300Multiple Airlines
Find Deal
Sat, Jan 17 - Thu, Jan 22
Multiple Airlines Logo
1:35 pm - 1:11 pmSNA-TYS
20h 36m1 stop
Multiple Airlines Logo
4:46 pm - 10:27 pmTYS-SNA
32h 41m2 stops
$309Multiple Airlines
Find Deal
Wed, Dec 17 - Mon, Dec 22
United Airlines Logo
12:29 pm - 11:44 pmSNA-TYS
8h 15m1 stop
United Airlines Logo
7:00 am - 11:35 amTYS-SNA
7h 35m1 stop
$311United Airlines
Find Deal
Tue, Mar 24 - Tue, Mar 31
Multiple Airlines Logo
3:26 pm - 10:22 pmSNA-TYS
27h 56m1 stop
Multiple Airlines Logo
4:52 pm - 12:42 pmTYS-SNA
22h 50m1 stop
$315Multiple Airlines
Find Deal
Sat, Dec 6 - Sun, Dec 14
Multiple Airlines Logo
11:11 am - 5:02 pmSNA-TYS
26h 51m1 stop
Multiple Airlines Logo
4:23 pm - 1:51 pmTYS-SNA
24h 28m2 stops
$316Multiple Airlines
Find Deal
Thu, Dec 18 - Thu, Jan 8
Multiple Airlines Logo
11:11 am - 5:02 pmSNA-TYS
26h 51m1 stop
Multiple Airlines Logo
10:00 am - 2:11 pmTYS-SNA
7h 11m1 stop
$318Multiple Airlines
Find Deal
Thu, Dec 18 - Thu, Jan 8

American Airlines flights from Santa Ana, California to Knoxville

Our best American Airlines deals on Santa Ana, California to Knoxville flight tickets
American Airlines
Feb 18
SNA6:45 amSanta Ana J. Wayne/Orange Cnty
7h 48m
1 stop
TYS5:33 pmKnoxville McGhee Tyson
Feb 21
TYS12:19 pmKnoxville McGhee Tyson
9h 08m
1 stop
SNA6:27 pmSanta Ana J. Wayne/Orange Cnty
$289
Find similar
American Airlines
Feb 18
SNA7:53 pmSanta Ana J. Wayne/Orange Cnty
9h 48m
2 stops
TYS8:41 amKnoxville McGhee Tyson
Feb 21
TYS5:35 amKnoxville McGhee Tyson
7h 33m
1 stop
SNA10:08 amSanta Ana J. Wayne/Orange Cnty
$294
Find similar
American Airlines
Feb 18
SNA7:53 pmSanta Ana J. Wayne/Orange Cnty
9h 48m
2 stops
TYS8:41 amKnoxville McGhee Tyson
Feb 21
TYS12:19 pmKnoxville McGhee Tyson
9h 44m
2 stops
SNA7:03 pmSanta Ana J. Wayne/Orange Cnty
$299
Find similar

Delta flights from Santa Ana, California to Knoxville

Our best Delta deals on Santa Ana, California to Knoxville flight tickets
Delta
Jan 17
SNA8:00 amSanta Ana J. Wayne/Orange Cnty
7h 58m
1 stop
TYS6:58 pmKnoxville McGhee Tyson
Jan 22
TYS4:06 pmKnoxville McGhee Tyson
9h 09m
1 stop
SNA10:15 pmSanta Ana J. Wayne/Orange Cnty
$363
Find similar
Delta
Jan 17
SNA8:00 amSanta Ana J. Wayne/Orange Cnty
7h 58m
1 stop
TYS6:58 pmKnoxville McGhee Tyson
Jan 22
TYS5:40 amKnoxville McGhee Tyson
9h 09m
1 stop
SNA11:49 amSanta Ana J. Wayne/Orange Cnty
$388
Find similar
Delta
Jan 8
SNA11:45 amSanta Ana J. Wayne/Orange Cnty
9h 00m
1 stop
TYS11:45 pmKnoxville McGhee Tyson
Jan 12
TYS6:09 pmKnoxville McGhee Tyson
7h 06m
1 stop
SNA10:15 pmSanta Ana J. Wayne/Orange Cnty
$437
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana, California to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 26, 2025.
Use the filters below to find and compare flights from Santa Ana, California to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sat 12/6

3:26 pm-10:22 pm

1 stop27h 56m

Knoxville McGhee Tyson

Sun 12/14

6:30 am-10:44 am

2 stops55h 14m

$271

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 2/18

6:45 am-5:33 pm

1 stop7h 48m

Knoxville McGhee Tyson

Sat 2/21

12:19 pm-6:27 pm

1 stop9h 08m

$289

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 2/18

7:53 pm-8:41 am

2 stops9h 48m

Knoxville McGhee Tyson

Sat 2/21

5:35 am-10:08 am

1 stop7h 33m

$294

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 2/18

7:53 pm-8:41 am

2 stops9h 48m

Knoxville McGhee Tyson

Sat 2/21

12:19 pm-7:03 pm

2 stops9h 44m

$299

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sat 1/17

3:55 pm-7:23 pm

1 stop24h 28m

Knoxville McGhee Tyson

Thu 1/22

10:00 am-11:32 am

2 stops28h 32m

$300

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 12/17

1:35 pm-1:11 pm

1 stop20h 36m

Knoxville McGhee Tyson

Mon 12/22

4:46 pm-10:27 pm

2 stops32h 41m

$309

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Tue 3/24

12:29 pm-11:44 pm

1 stop8h 15m

Knoxville McGhee Tyson

Tue 3/31

7:00 am-11:35 am

1 stop7h 35m

$311

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sat 12/6

3:26 pm-10:22 pm

1 stop27h 56m

Knoxville McGhee Tyson

Sun 12/14

4:52 pm-12:42 pm

1 stop22h 50m

$315

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 12/18

11:11 am-5:02 pm

1 stop26h 51m

Knoxville McGhee Tyson

Thu 1/8

4:23 pm-1:51 pm

2 stops24h 28m

$316

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 12/18

11:11 am-5:02 pm

1 stop26h 51m

Knoxville McGhee Tyson

Thu 1/8

10:00 am-2:11 pm

1 stop7h 11m

$318

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Santa Ana, California to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Santa Ana, California, with most prices found around $338. If you aren’t able to travel during the month of August, then book flights to Knoxville from Santa Ana, California during September instead. Flights to Knoxville in September, while not as cheap as those in August, still average around $377.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Santa Ana, California to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $387. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Santa Ana, California to Knoxville for around $552.

What is the cheapest time of day to depart on your flight to Knoxville?

In the afternoon is the cheapest time of day to fly from Santa Ana, California to Knoxville when you can find flight prices for as low as $399. Flying to Knoxville in the afternoon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the evening when prices are around $442.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Santa Ana, California when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $426 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Santa Ana, California for as low as $302 on momondo.

Can stopping save me money on Santa Ana, California to Knoxville flights?

You could potentially save up to 35% on your flight if you consider stops on a Santa Ana, California to Knoxville flight.

How have Santa Ana, California to Knoxville flight prices changed over time?

As of November 2025, prices for Santa Ana, California to Knoxville flights are approximately 2% cheaper when compared to flights at the same time last year.

When to book flights from Santa Ana, California to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana, California to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana, California to Knoxville (SNA to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana, California to Knoxville

Fastest flight time

6h 05m

Direct flights

None
The fastest flight from Santa Ana, California to Knoxville takes 6h 05m
There are no direct flights from Santa Ana, California to Knoxville. There are no popular flight routes from Santa Ana, California to Knoxville.
Search flight deals

  • How far is Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson by plane?

    Santa Ana J. Wayne/Orange Cnty and Knoxville McGhee Tyson are 1919.8 mi apart from one another. 5h 58m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santa Ana, California to Knoxville?

Best airlines flying from Santa Ana, California to Knoxville

Compare and see reviews for airlines that fly from Santa Ana, California to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $239Free CancellationRating
7.4
9,046 reviews
Search United Airlines flights
American AirlinesPriceFrom $264Free CancellationRating
7.2
11,038 reviews
Search American Airlines flights
DeltaPriceFrom $276Free CancellationRating
7.9
7,998 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santa Ana to Knoxville for you.

Can I find flights from Santa Ana to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Santa Ana to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Santa Ana to Knoxville?

momondo helps you find the best flight between Santa Ana and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santa Ana to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Santa Ana to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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