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Cheap flights from Santa Ana to Knoxville from $219

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana to Knoxville departing on 11/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Santa Ana to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
3:03 pm - 12:08 amSNA-TYS
6h 05m1 stop
American Airlines Logo
5:10 am - 9:53 amTYS-SNA
7h 43m1 stop
$289American Airlines
Find Deal
Sat, Nov 8 - Tue, Nov 11
United Airlines Logo
11:10 am - 11:59 pmSNA-TYS
9h 49m2 stops
United Airlines Logo
7:00 am - 11:12 amTYS-SNA
7h 12m1 stop
$294United Airlines
Find Deal
Sat, Nov 8 - Tue, Nov 11
Delta Logo
5:40 pm - 9:37 amSNA-TYS
12h 57m2 stops
Delta Logo
5:35 am - 4:24 pmTYS-SNA
13h 49m2 stops
$299Delta
Find Deal
Sat, Nov 8 - Tue, Nov 11
Multiple Airlines Logo
7:15 am - 5:02 pmSNA-TYS
6h 47m1 stop
Multiple Airlines Logo
6:30 am - 11:40 amTYS-SNA
8h 10m1 stop
$316Multiple Airlines
Find Deal
Mon, Dec 8 - Sun, Dec 14
Multiple Airlines Logo
6:56 pm - 12:57 pmSNA-TYS
39h 01m2 stops
Multiple Airlines Logo
6:30 am - 11:40 amTYS-SNA
8h 10m1 stop
$330Multiple Airlines
Find Deal
Mon, Dec 8 - Sun, Dec 14
American Airlines Logo
7:30 am - 7:01 pmSNA-TYS
8h 31m1 stop
American Airlines Logo
5:10 am - 9:53 amTYS-SNA
7h 43m1 stop
$339American Airlines
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Wed, Oct 29 - Wed, Nov 5
Delta Logo
11:48 am - 9:13 pmSNA-TYS
6h 25m1 stop
Delta Logo
5:44 am - 12:54 pmTYS-SNA
10h 10m2 stops
$344Delta
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Wed, Oct 29 - Wed, Nov 5
Delta Logo
7:00 am - 11:07 pmSNA-TYS
13h 07m2 stops
Delta Logo
5:44 am - 12:54 pmTYS-SNA
10h 10m2 stops
$349Delta
Find Deal
Wed, Oct 29 - Wed, Nov 5
United Airlines Logo
12:08 pm - 11:43 pmSNA-TYS
8h 35m1 stop
United Airlines Logo
7:00 am - 11:41 amTYS-SNA
7h 41m1 stop
$389United Airlines
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Tue, Oct 21 - Sat, Oct 25
Alaska Airlines Logo
3:01 pm - 10:30 amSNA-TYS
16h 29m2 stops
Alaska Airlines Logo
8:06 am - 4:37 pmTYS-SNA
11h 31m2 stops
$543Alaska Airlines
Find Deal
Wed, Dec 10 - Sat, Dec 13

American Airlines flights from Santa Ana to Knoxville

Our best American Airlines deals on Santa Ana to Knoxville flight tickets
American Airlines
Nov 8
SNA3:03 pmSanta Ana J. Wayne/Orange Cnty
6h 05m
1 stop
TYS12:08 amKnoxville McGhee Tyson
Nov 11
TYS5:10 amKnoxville McGhee Tyson
7h 43m
1 stop
SNA9:53 amSanta Ana J. Wayne/Orange Cnty
$289
Find similar
American Airlines
Oct 29
SNA7:30 amSanta Ana J. Wayne/Orange Cnty
8h 31m
1 stop
TYS7:01 pmKnoxville McGhee Tyson
Nov 5
TYS5:10 amKnoxville McGhee Tyson
7h 43m
1 stop
SNA9:53 amSanta Ana J. Wayne/Orange Cnty
$339
Find similar
American Airlines
Feb 18
SNA11:55 amSanta Ana J. Wayne/Orange Cnty
6h 28m
1 stop
TYS9:23 pmKnoxville McGhee Tyson
Feb 21
TYS3:00 pmKnoxville McGhee Tyson
10h 13m
1 stop
SNA10:13 pmSanta Ana J. Wayne/Orange Cnty
$379
Find similar

United Airlines flights from Santa Ana to Knoxville

Our best United Airlines deals on Santa Ana to Knoxville flight tickets
United Airlines
Nov 8
SNA11:10 amSanta Ana J. Wayne/Orange Cnty
9h 49m
2 stops
TYS11:59 pmKnoxville McGhee Tyson
Nov 11
TYS7:00 amKnoxville McGhee Tyson
7h 12m
1 stop
SNA11:12 amSanta Ana J. Wayne/Orange Cnty
$294
Find similar
United Airlines
Oct 21
SNA12:08 pmSanta Ana J. Wayne/Orange Cnty
8h 35m
1 stop
TYS11:43 pmKnoxville McGhee Tyson
Oct 25
TYS7:00 amKnoxville McGhee Tyson
7h 41m
1 stop
SNA11:41 amSanta Ana J. Wayne/Orange Cnty
$389
Find similar
United Airlines
Oct 21
SNA11:32 amSanta Ana J. Wayne/Orange Cnty
7h 56m
1 stop
TYS10:28 pmKnoxville McGhee Tyson
Oct 25
TYS7:15 amKnoxville McGhee Tyson
10h 56m
2 stops
SNA3:11 pmSanta Ana J. Wayne/Orange Cnty
$394
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 6, 2025.
Use the filters below to find and compare flights from Santa Ana to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sat 11/8

3:03 pm-12:08 am

1 stop6h 05m

Knoxville McGhee Tyson

Tue 11/11

5:10 am-9:53 am

1 stop7h 43m

$289

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sat 11/8

11:10 am-11:59 pm

2 stops9h 49m

Knoxville McGhee Tyson

Tue 11/11

7:00 am-11:12 am

1 stop7h 12m

$294

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sat 11/8

5:40 pm-9:37 am

2 stops12h 57m

Knoxville McGhee Tyson

Tue 11/11

5:35 am-4:24 pm

2 stops13h 49m

$299

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Mon 12/8

7:15 am-5:02 pm

1 stop6h 47m

Knoxville McGhee Tyson

Sun 12/14

6:30 am-11:40 am

1 stop8h 10m

$316

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Mon 12/8

6:56 pm-12:57 pm

2 stops39h 01m

Knoxville McGhee Tyson

Sun 12/14

6:30 am-11:40 am

1 stop8h 10m

$330

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 10/29

7:30 am-7:01 pm

1 stop8h 31m

Knoxville McGhee Tyson

Wed 11/5

5:10 am-9:53 am

1 stop7h 43m

$339

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 10/29

11:48 am-9:13 pm

1 stop6h 25m

Knoxville McGhee Tyson

Wed 11/5

5:44 am-12:54 pm

2 stops10h 10m

$344

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 10/29

7:00 am-11:07 pm

2 stops13h 07m

Knoxville McGhee Tyson

Wed 11/5

5:44 am-12:54 pm

2 stops10h 10m

$349

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Tue 10/21

12:08 pm-11:43 pm

1 stop8h 35m

Knoxville McGhee Tyson

Sat 10/25

7:00 am-11:41 am

1 stop7h 41m

$389

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 12/10

3:01 pm-10:30 am

2 stops16h 29m

Knoxville McGhee Tyson

Sat 12/13

8:06 am-4:37 pm

2 stops11h 31m

$543

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Santa Ana to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Santa Ana, with most prices found around $338. If you aren’t able to travel during the month of August, then book flights to Knoxville from Santa Ana during September instead. Flights to Knoxville in September, while not as cheap as those in August, still average around $377.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Santa Ana to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $387. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Santa Ana to Knoxville for around $552.

What is the cheapest time of day to depart on your flight to Knoxville?

In the afternoon is the cheapest time of day to fly from Santa Ana to Knoxville when you can find flight prices for as low as $399. Flying to Knoxville in the afternoon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the evening when prices are around $442.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Santa Ana when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $418 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Santa Ana for as low as $302 on momondo.

Can stopping save me money on Santa Ana to Knoxville flights?

You could potentially save up to 53% on your flight if you consider stops on a Santa Ana to Knoxville flight.

How have Santa Ana to Knoxville flight prices changed over time?

As of October 2025, prices for Santa Ana to Knoxville flights are approximately 110% more expensive when compared to flights at the same time last year.

When to book flights from Santa Ana to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana to Knoxville (SNA to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana to Knoxville

Direct flights

None
There are no direct flights from Santa Ana to Knoxville. There are no popular flight routes from Santa Ana to Knoxville.
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  • How far is Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson by plane?

    Santa Ana J. Wayne/Orange Cnty and Knoxville McGhee Tyson are 1919.8 mi apart from one another. 5h 58m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santa Ana to Knoxville?

Best airlines flying from Santa Ana to Knoxville

Compare and see reviews for airlines that fly from Santa Ana to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $192Free CancellationRating
7.9
7,967 reviews
Search Delta flights
United AirlinesPriceFrom $239Free CancellationRating
7.4
8,957 reviews
Search United Airlines flights
American AirlinesPriceFrom $277Free CancellationRating
7.2
11,040 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santa Ana to Knoxville for you.

Can I find flights from Santa Ana to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Santa Ana to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Santa Ana to Knoxville?

momondo helps you find the best flight between Santa Ana and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santa Ana to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Santa Ana to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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