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Cheap flights from Santa Ana, California to Knoxville from $95

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana, California to Knoxville departing on 1/29. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Santa Ana, California to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:45 am - 8:40 pm
SNA
-
TYS
9h 55m1 stop
American Airlines Logo
2:54 pm - 9:17 pm
TYS
-
SNA
9h 23m1 stop
$289American Airlines
Wed, Feb 18 - Sat, Feb 21
Multiple Airlines Logo
6:45 am - 6:44 pm
SNA
-
TYS
32h 59m2 stops
Multiple Airlines Logo
7:35 am - 8:57 pm
TYS
-
SNA
16h 22m1 stop
$293Multiple Airlines
Wed, Feb 4 - Mon, Feb 9
American Airlines Logo
7:48 pm - 8:42 am
SNA
-
TYS
9h 54m2 stops
American Airlines Logo
2:54 pm - 9:17 pm
TYS
-
SNA
9h 23m1 stop
$294American Airlines
Wed, Feb 18 - Sat, Feb 21
American Airlines Logo
12:26 pm - 12:28 am
SNA
-
TYS
9h 02m2 stops
American Airlines Logo
12:21 pm - 7:31 pm
TYS
-
SNA
10h 10m2 stops
$300American Airlines
Wed, Feb 18 - Sat, Feb 21
Multiple Airlines Logo
4:37 pm - 11:01 pm
SNA
-
TYS
27h 24m1 stop
Multiple Airlines Logo
9:00 am - 4:25 pm
TYS
-
SNA
10h 25m1 stop
$312Multiple Airlines
Thu, Feb 12 - Sun, Feb 15
United Airlines Logo
11:10 am - 11:03 pm
SNA
-
TYS
8h 53m2 stops
United Airlines Logo
4:30 pm - 8:47 pm
TYS
-
SNA
7h 17m1 stop
$314United Airlines
Wed, Apr 8 - Wed, Apr 15
Multiple Airlines Logo
4:37 pm - 6:44 pm
SNA
-
TYS
23h 07m2 stops
Multiple Airlines Logo
7:35 am - 8:57 pm
TYS
-
SNA
16h 22m1 stop
$321Multiple Airlines
Wed, Feb 4 - Mon, Feb 9
Multiple Airlines Logo
8:58 am - 10:54 pm
SNA
-
TYS
10h 56m1 stop
Multiple Airlines Logo
4:20 pm - 8:55 am
TYS
-
SNA
43h 35m2 stops
$332Multiple Airlines
Mon, Mar 2 - Mon, Mar 9
American Airlines Logo
10:53 am - 10:47 pm
SNA
-
TYS
8h 54m1 stop
American Airlines Logo
4:41 pm - 8:55 pm
TYS
-
SNA
7h 14m1 stop
$339American Airlines
Wed, Feb 4 - Mon, Feb 9
Multiple Airlines Logo
2:39 pm - 4:50 pm
SNA
-
TYS
23h 11m1 stop
Multiple Airlines Logo
10:58 am - 8:13 am
TYS
-
SNA
24h 15m2 stops
$343Multiple Airlines
Thu, Feb 5 - Wed, Feb 11

United Airlines flights from Santa Ana, California to Knoxville

Our best United Airlines deals on Santa Ana, California to Knoxville flight tickets
United Airlines
Apr 8
SNA11:10 amSanta Ana J. Wayne/Orange Cnty
8h 53m
2 stops
TYS11:03 pmKnoxville McGhee Tyson
Apr 15
TYS4:30 pmKnoxville McGhee Tyson
7h 17m
1 stop
SNA8:47 pmSanta Ana J. Wayne/Orange Cnty
$314
United Airlines
May 19
SNA12:10 pmSanta Ana J. Wayne/Orange Cnty
8h 30m
1 stop
TYS11:40 pmKnoxville McGhee Tyson
May 23
TYS8:45 amKnoxville McGhee Tyson
7h 29m
1 stop
SNA1:14 pmSanta Ana J. Wayne/Orange Cnty
$399
United Airlines
May 19
SNA9:00 amSanta Ana J. Wayne/Orange Cnty
11h 40m
2 stops
TYS11:40 pmKnoxville McGhee Tyson
May 23
TYS8:45 amKnoxville McGhee Tyson
9h 19m
1 stop
SNA3:04 pmSanta Ana J. Wayne/Orange Cnty
$404

Southwest flights from Santa Ana, California to Knoxville

Our best Southwest deals on Santa Ana, California to Knoxville flight tickets
Southwest
Apr 8
SNA6:45 amSanta Ana J. Wayne/Orange Cnty
9h 55m
2 stops
TYS7:40 pmKnoxville McGhee Tyson
Apr 15
TYS2:55 pmKnoxville McGhee Tyson
9h 50m
2 stops
SNA9:45 pmSanta Ana J. Wayne/Orange Cnty
$355
Southwest
May 27
SNA6:45 amSanta Ana J. Wayne/Orange Cnty
9h 55m
2 stops
TYS7:40 pmKnoxville McGhee Tyson
May 30
TYS3:55 pmKnoxville McGhee Tyson
6h 20m
1 stop
SNA7:15 pmSanta Ana J. Wayne/Orange Cnty
$380
Southwest
May 20
SNA6:45 amSanta Ana J. Wayne/Orange Cnty
9h 55m
2 stops
TYS7:40 pmKnoxville McGhee Tyson
May 25
TYS2:45 pmKnoxville McGhee Tyson
9h 50m
2 stops
SNA9:35 pmSanta Ana J. Wayne/Orange Cnty
$469

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana, California to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 12, 2026.
Use the filters below to find and compare flights from Santa Ana, California to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 2/18

7:45 am-8:40 pm

1 stop9h 55m

Knoxville McGhee Tyson

Sat 2/21

2:54 pm-9:17 pm

1 stop9h 23m

$289

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 2/4

6:45 am-6:44 pm

2 stops32h 59m

Knoxville McGhee Tyson

Mon 2/9

7:35 am-8:57 pm

1 stop16h 22m

$293

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 2/18

7:48 pm-8:42 am

2 stops9h 54m

Knoxville McGhee Tyson

Sat 2/21

2:54 pm-9:17 pm

1 stop9h 23m

$294

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 2/18

12:26 pm-12:28 am

2 stops9h 02m

Knoxville McGhee Tyson

Sat 2/21

12:21 pm-7:31 pm

2 stops10h 10m

$300

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 2/12

4:37 pm-11:01 pm

1 stop27h 24m

Knoxville McGhee Tyson

Sun 2/15

9:00 am-4:25 pm

1 stop10h 25m

$312

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 4/8

11:10 am-11:03 pm

2 stops8h 53m

Knoxville McGhee Tyson

Wed 4/15

4:30 pm-8:47 pm

1 stop7h 17m

$314

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 2/4

4:37 pm-6:44 pm

2 stops23h 07m

Knoxville McGhee Tyson

Mon 2/9

7:35 am-8:57 pm

1 stop16h 22m

$321

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Mon 3/2

8:58 am-10:54 pm

1 stop10h 56m

Knoxville McGhee Tyson

Mon 3/9

4:20 pm-8:55 am

2 stops43h 35m

$332

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 2/4

10:53 am-10:47 pm

1 stop8h 54m

Knoxville McGhee Tyson

Mon 2/9

4:41 pm-8:55 pm

1 stop7h 14m

$339

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 2/5

2:39 pm-4:50 pm

1 stop23h 11m

Knoxville McGhee Tyson

Wed 2/11

10:58 am-8:13 am

2 stops24h 15m

$343

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Santa Ana, California to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Santa Ana, California, with most prices found around $338. If you aren’t able to travel during the month of August, then book flights to Knoxville from Santa Ana, California during November instead. Flights to Knoxville in November, while not as cheap as those in August, still average around $362.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Santa Ana, California when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $423 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Santa Ana, California for as low as $288 on momondo.

Can stopping save me money on Santa Ana, California to Knoxville flights?

You could potentially save up to 33% on your flight if you consider stops on a Santa Ana, California to Knoxville flight.

How have Santa Ana, California to Knoxville flight prices changed over time?

As of January 2026, prices for Santa Ana, California to Knoxville flights are approximately 1% cheaper when compared to flights at the same time last year.

When to book flights from Santa Ana, California to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana, California to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana, California to Knoxville (SNA to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana, California to Knoxville

Fastest flight time

6h 19m

Direct flights

None
The fastest flight from Santa Ana, California to Knoxville takes 6h 19m
There are no direct flights from Santa Ana, California to Knoxville. There are no popular flight routes from Santa Ana, California to Knoxville.
Search flight deals

  • How far is Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson by plane?

    Santa Ana J. Wayne/Orange Cnty and Knoxville McGhee Tyson are 1919.8 mi apart from one another. 6h 19m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santa Ana, California to Knoxville?

Best airlines flying from Santa Ana, California to Knoxville

Compare and see reviews for airlines that fly from Santa Ana, California to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $239Free CancellationRating
7.4
9,143 reviews
Search United Airlines flights
American AirlinesPriceFrom $257Free CancellationRating
7.2
11,109 reviews
Search American Airlines flights
DeltaPriceFrom $276Free CancellationRating
7.9
8,033 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Murphy
Crossville
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santa Ana to Knoxville for you.

Can I find flights from Santa Ana to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Santa Ana to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Santa Ana to Knoxville?

momondo helps you find the best flight between Santa Ana and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santa Ana to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Santa Ana to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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