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Cheap flights from Santa Ana, California to Knoxville from $176

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Santa Ana, California to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:30 am - 10:35 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
12h 05m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
8:43 pm - 7:11 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
25h 28m1 stop Las Vegas Harry Reid Intl
$331Multiple Airlines
Fri, Nov 13 - Sun, Nov 15
Multiple Airlines Logo
7:30 am - 10:06 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
11h 36m2 stops Las Vegas Harry Reid Intl Phoenix Sky Harbor Intl
Multiple Airlines Logo
8:43 pm - 7:11 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
25h 28m1 stop Las Vegas Harry Reid Intl
$340Multiple Airlines
Thu, Nov 12 - Sun, Nov 15
American Airlines Logo
1:20 pm - 11:40 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
7h 20m1 stop Dallas/Fort Worth
American Airlines Logo
5:30 am - 9:57 amTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
7h 27m1 stop Dallas/Fort Worth
$363American Airlines
Thu, Dec 10 - Tue, Dec 15
American Airlines Logo
12:10 pm - 11:19 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
8h 09m1 stop Dallas/Fort Worth
American Airlines Logo
12:21 pm - 5:46 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
8h 25m1 stop Dallas/Fort Worth
$363American Airlines
Mon, Feb 1 - Sat, Feb 6
United Airlines Logo
8:10 am - 6:23 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
7h 13m1 stop Houston George Bush Intcntl
United Airlines Logo
5:55 pm - 10:30 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
7h 35m1 stop Chicago O'Hare Intl
$363United Airlines
Tue, Feb 2 - Sat, Feb 6
Delta Logo
2:30 pm - 11:57 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
6h 27m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:40 am - 11:48 amTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
9h 08m1 stop Atlanta Hartsfield-Jackson
$363Delta
Thu, Dec 10 - Tue, Dec 15
Delta Logo
2:30 pm - 11:57 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
6h 27m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:40 am - 11:48 amTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
9h 08m1 stop Atlanta Hartsfield-Jackson
$363Delta
Fri, Dec 11 - Tue, Dec 15
United Airlines Logo
7:49 pm - 10:10 amSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
11h 21m2 stops San Francisco Chicago O'Hare Intl
United Airlines Logo
5:28 pm - 9:53 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
7h 25m1 stop Houston George Bush Intcntl
$368United Airlines
Mon, Feb 1 - Sat, Feb 6
Southwest Logo
6:45 am - 3:45 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
6h 00m1 stop Denver Intl
Southwest Logo
2:40 pm - 9:05 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
9h 25m2 stops Denver Intl Phoenix Sky Harbor Intl
$368Southwest
Mon, Feb 1 - Fri, Feb 5
Southwest Logo
7:00 am - 7:45 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
9h 45m2 stops Austin Bergstrom Nashville Intl
Southwest Logo
4:15 pm - 9:45 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
8h 30m1 stop Denver Intl
$385Southwest
Thu, Dec 10 - Tue, Dec 15

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United Airlines flights from Santa Ana, California to Knoxville

Our best United Airlines deals on Santa Ana, California to Knoxville flight tickets
United Airlines
Feb 1
SNA7:49 pmSanta Ana J. Wayne/Orange Cnty
11h 21m
2 stops
TYS10:10 amKnoxville McGhee Tyson
Feb 6
TYS5:28 pmKnoxville McGhee Tyson
7h 25m
1 stop
SNA9:53 pmSanta Ana J. Wayne/Orange Cnty
$368
United Airlines
Nov 7
SNA8:46 amSanta Ana J. Wayne/Orange Cnty
9h 08m
2 stops
TYS8:54 pmKnoxville McGhee Tyson
Nov 9
TYS5:05 pmKnoxville McGhee Tyson
7h 55m
1 stop
SNA10:00 pmSanta Ana J. Wayne/Orange Cnty
$422
United Airlines
Nov 14
SNA1:09 pmSanta Ana J. Wayne/Orange Cnty
6h 23m
1 stop
TYS10:32 pmKnoxville McGhee Tyson
Nov 21
TYS5:03 pmKnoxville McGhee Tyson
7h 16m
1 stop
SNA9:19 pmSanta Ana J. Wayne/Orange Cnty
$460

American Airlines flights from Santa Ana, California to Knoxville

Our best American Airlines deals on Santa Ana, California to Knoxville flight tickets
American Airlines
Feb 1
SNA12:10 pmSanta Ana J. Wayne/Orange Cnty
8h 09m
1 stop
TYS11:19 pmKnoxville McGhee Tyson
Feb 6
TYS12:21 pmKnoxville McGhee Tyson
8h 25m
1 stop
SNA5:46 pmSanta Ana J. Wayne/Orange Cnty
$363
American Airlines
Dec 3
SNA1:20 pmSanta Ana J. Wayne/Orange Cnty
7h 20m
1 stop
TYS11:40 pmKnoxville McGhee Tyson
Dec 6
TYS5:30 amKnoxville McGhee Tyson
8h 35m
1 stop
SNA11:05 amSanta Ana J. Wayne/Orange Cnty
$398
American Airlines
Feb 13
SNA10:46 amSanta Ana J. Wayne/Orange Cnty
6h 52m
1 stop
TYS8:38 pmKnoxville McGhee Tyson
Feb 20
TYS6:46 pmKnoxville McGhee Tyson
6h 44m
1 stop
SNA10:30 pmSanta Ana J. Wayne/Orange Cnty
$417

momondo Fare Finder

 
Use the filters below to find and compare flights from Santa Ana, California to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santa AnaKnoxville

SNA Santa Ana J. Wayne/Orange Cnty - TYS Knoxville McGhee Tyson

SNATYS

Santa Ana J. Wayne/Orange Cnty

Fri 11/13

7:30 am-10:35 pm

1 stop12h 05m

Knoxville McGhee Tyson

Sun 11/15

8:43 pm-7:11 pm

1 stop25h 28m

$331

Santa AnaKnoxville

SNA Santa Ana J. Wayne/Orange Cnty - TYS Knoxville McGhee Tyson

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 11/12

7:30 am-10:06 pm

2 stops11h 36m

Knoxville McGhee Tyson

Sun 11/15

8:43 pm-7:11 pm

1 stop25h 28m

$340
Quickest round-trip

Santa AnaKnoxville

SNA Santa Ana J. Wayne/Orange Cnty - TYS Knoxville McGhee Tyson

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 12/10

1:20 pm-11:40 pm

1 stop7h 20m

Knoxville McGhee Tyson

Tue 12/15

5:30 am-9:57 am

1 stop7h 27m

$363

Santa AnaKnoxville

SNA Santa Ana J. Wayne/Orange Cnty - TYS Knoxville McGhee Tyson

SNATYS

Santa Ana J. Wayne/Orange Cnty

Mon 2/1

12:10 pm-11:19 pm

1 stop8h 09m

Knoxville McGhee Tyson

Sat 2/6

12:21 pm-5:46 pm

1 stop8h 25m

$363

Santa AnaKnoxville

SNA Santa Ana J. Wayne/Orange Cnty - TYS Knoxville McGhee Tyson

SNATYS

Santa Ana J. Wayne/Orange Cnty

Tue 2/2

8:10 am-6:23 pm

1 stop7h 13m

Knoxville McGhee Tyson

Sat 2/6

5:55 pm-10:30 pm

1 stop7h 35m

$363

Santa AnaKnoxville

SNA Santa Ana J. Wayne/Orange Cnty - TYS Knoxville McGhee Tyson

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 12/10

2:30 pm-11:57 pm

1 stop6h 27m

Knoxville McGhee Tyson

Tue 12/15

5:40 am-11:48 am

1 stop9h 08m

$363

Santa AnaKnoxville

SNA Santa Ana J. Wayne/Orange Cnty - TYS Knoxville McGhee Tyson

SNATYS

Santa Ana J. Wayne/Orange Cnty

Fri 12/11

2:30 pm-11:57 pm

1 stop6h 27m

Knoxville McGhee Tyson

Tue 12/15

5:40 am-11:48 am

1 stop9h 08m

$363

Santa AnaKnoxville

SNA Santa Ana J. Wayne/Orange Cnty - TYS Knoxville McGhee Tyson

SNATYS

Santa Ana J. Wayne/Orange Cnty

Mon 2/1

7:49 pm-10:10 am

2 stops11h 21m

Knoxville McGhee Tyson

Sat 2/6

5:28 pm-9:53 pm

1 stop7h 25m

$368

Santa AnaKnoxville

SNA Santa Ana J. Wayne/Orange Cnty - TYS Knoxville McGhee Tyson

SNATYS

Santa Ana J. Wayne/Orange Cnty

Mon 2/1

6:45 am-3:45 pm

1 stop6h 00m

Knoxville McGhee Tyson

Fri 2/5

2:40 pm-9:05 pm

2 stops9h 25m

$368

Santa AnaKnoxville

SNA Santa Ana J. Wayne/Orange Cnty - TYS Knoxville McGhee Tyson

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 12/10

7:00 am-7:45 pm

2 stops9h 45m

Knoxville McGhee Tyson

Tue 12/15

4:15 pm-9:45 pm

1 stop8h 30m

$385

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Santa Ana, California to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santa Ana, California and Knoxville?

Prices are currently low for flights on this route.

Typical prices usually range from $374 to $566.
The lowest price recently found on this route was $331.

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from Santa Ana, California, with most prices found around $452. If you aren’t able to travel during the month of January, then book flights to Knoxville from Santa Ana, California during February instead. Flights to Knoxville in February, while not as cheap as those in January, still average around $474.

How far in advance should I book a flight from Santa Ana, California to Knoxville?

You are more likely to see cheaper flights to Knoxville from Santa Ana, California when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $572 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Santa Ana, California for as low as $417 on momondo.

Can stopping save me money on Santa Ana, California to Knoxville flights?

You could potentially save up to 46% on your flight if you consider stops on a Santa Ana, California to Knoxville flight.

How have Santa Ana, California to Knoxville flight prices changed over time?

As of October 2026, prices for Santa Ana, California to Knoxville flights are approximately 27% more expensive when compared to flights at the same time last year.

When to book flights from Santa Ana, California to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana, California to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana, California to Knoxville (SNA to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana, California to Knoxville

Best Price Found

$176

Fastest flight time

6h 00m

Direct flights

None
The best one-way flight to Knoxville from Santa Ana, California in the past 72 hours is $176. The best round-trip flight deal from Santa Ana, California to Knoxville found on momondo in the last 72 hours is $331.
The fastest flight from Santa Ana, California to Knoxville takes 6h 00m
There are no direct flights from Santa Ana, California to Knoxville. There are no popular flight routes from Santa Ana, California to Knoxville.
Search flight deals

Frequently asked questions about flying from Santa Ana, California to Knoxville

  • How far is Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson by plane?

    Santa Ana J. Wayne/Orange Cnty and Knoxville McGhee Tyson are 1919.8 mi apart from one another. 6h 00m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santa Ana, California to Knoxville?

Best airlines flying from Santa Ana, California to Knoxville

Compare and see reviews for airlines that fly from Santa Ana, California to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $229Free CancellationRating
7.8
8,658 reviews
Search Delta flights
American AirlinesPriceFrom $289Free CancellationRating
7.0
12,178 reviews
Search American Airlines flights
United AirlinesPriceFrom $328Free CancellationRating
7.4
10,381 reviews
Search United Airlines flights
SouthwestPriceFrom $412Free CancellationRating
7.9
4,214 reviews
Search Southwest flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Crossville
Maryville
Murphy
Oak Ridge
Kodak
Lenoir City
Newport
Dandridge
Clinton
Rockford
Jefferson City

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santa Ana to Knoxville for you.

Can I find flights from Santa Ana to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Santa Ana to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Santa Ana to Knoxville?

momondo helps you find the best flight between Santa Ana and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santa Ana to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Santa Ana to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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