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Cheap flights from Santa Ana to Knoxville from $126

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana to Knoxville departing on 6/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Santa Ana to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:45 am - 10:51 pm
SNA
-
TYS
13h 06m
1 stop
Multiple Airlines Logo
4:28 pm - 10:44 am
TYS
-
SNA
21h 16m
1 stop
$280Multiple Airlines
Fri, Apr 24 - Sun, Apr 26
Multiple Airlines Logo
8:55 am - 7:37 pm
SNA
-
TYS
7h 42m
1 stop
Multiple Airlines Logo
7:00 am - 8:09 am
TYS
-
SNA
28h 09m
1 stop
$299Multiple Airlines
Mon, Aug 24 - Sun, Aug 30
Multiple Airlines Logo
1:50 pm - 11:27 pm
SNA
-
TYS
6h 37m
1 stop
Multiple Airlines Logo
7:00 am - 8:09 am
TYS
-
SNA
28h 09m
1 stop
$300Multiple Airlines
Sun, Aug 16 - Sun, Aug 30
Multiple Airlines Logo
9:54 am - 1:59 pm
SNA
-
TYS
25h 05m
1 stop
Multiple Airlines Logo
6:00 am - 3:38 pm
TYS
-
SNA
36h 38m
2 stops
$321Multiple Airlines
Sat, May 23 - Fri, May 29
Multiple Airlines Logo
11:14 am - 10:51 pm
SNA
-
TYS
8h 37m
1 stop
Multiple Airlines Logo
1:14 pm - 9:09 am
TYS
-
SNA
22h 55m
2 stops
$322Multiple Airlines
Mon, May 11 - Thu, May 14
Multiple Airlines Logo
1:50 pm - 11:27 pm
SNA
-
TYS
6h 37m
1 stop
Multiple Airlines Logo
7:00 am - 8:09 am
TYS
-
SNA
28h 09m
1 stop
$323Multiple Airlines
Sun, Aug 16 - Thu, Aug 27
Multiple Airlines Logo
11:14 am - 10:51 pm
SNA
-
TYS
8h 37m
1 stop
Multiple Airlines Logo
8:32 pm - 9:05 pm
TYS
-
SNA
27h 33m
2 stops
$324Multiple Airlines
Mon, May 11 - Mon, May 18
Multiple Airlines Logo
11:14 am - 10:51 pm
SNA
-
TYS
8h 37m
1 stop
Multiple Airlines Logo
1:14 pm - 9:09 am
TYS
-
SNA
22h 55m
2 stops
$325Multiple Airlines
Mon, May 11 - Thu, May 14
Multiple Airlines Logo
7:56 pm - 6:03 pm
SNA
-
TYS
19h 07m
2 stops
Multiple Airlines Logo
1:43 pm - 10:08 pm
TYS
-
SNA
11h 25m
1 stop
$326Multiple Airlines
Fri, May 1 - Mon, May 4
Multiple Airlines Logo
7:30 am - 1:49 pm
SNA
-
TYS
27h 19m
2 stops
Multiple Airlines Logo
7:00 am - 8:09 am
TYS
-
SNA
28h 09m
1 stop
$327Multiple Airlines
Wed, Aug 19 - Sun, Aug 30

United Airlines flights from Santa Ana to Knoxville

Our best United Airlines deals on Santa Ana to Knoxville flight tickets
United Airlines
Apr 21
SNA12:15 pmSanta Ana J. Wayne/Orange Cnty
8h 26m
1 stop
TYS11:41 pmKnoxville McGhee Tyson
Apr 23
TYS7:05 amKnoxville McGhee Tyson
9h 31m
1 stop
SNA1:36 pmSanta Ana J. Wayne/Orange Cnty
$543
United Airlines
Apr 21
SNA11:10 amSanta Ana J. Wayne/Orange Cnty
9h 31m
2 stops
TYS11:41 pmKnoxville McGhee Tyson
Apr 23
TYS7:05 amKnoxville McGhee Tyson
7h 08m
1 stop
SNA11:13 amSanta Ana J. Wayne/Orange Cnty
$548
United Airlines
Apr 18
SNA8:00 amSanta Ana J. Wayne/Orange Cnty
7h 15m
1 stop
TYS6:15 pmKnoxville McGhee Tyson
Apr 21
TYS7:05 amKnoxville McGhee Tyson
7h 08m
1 stop
SNA11:13 amSanta Ana J. Wayne/Orange Cnty
$609

Southwest flights from Santa Ana to Knoxville

Our best Southwest deals on Santa Ana to Knoxville flight tickets
Southwest
Sep 15
SNA6:45 amSanta Ana J. Wayne/Orange Cnty
9h 10m
2 stops
TYS6:55 pmKnoxville McGhee Tyson
Sep 22
TYS3:00 pmKnoxville McGhee Tyson
8h 55m
1 stop
SNA8:55 pmSanta Ana J. Wayne/Orange Cnty
$354
Southwest
Aug 4
SNA6:45 amSanta Ana J. Wayne/Orange Cnty
9h 10m
2 stops
TYS6:55 pmKnoxville McGhee Tyson
Aug 8
TYS6:50 amKnoxville McGhee Tyson
10h 00m
2 stops
SNA1:50 pmSanta Ana J. Wayne/Orange Cnty
$359
Southwest
May 23
SNA7:15 amSanta Ana J. Wayne/Orange Cnty
9h 20m
2 stops
TYS7:35 pmKnoxville McGhee Tyson
May 28
TYS6:35 amKnoxville McGhee Tyson
10h 10m
2 stops
SNA1:45 pmSanta Ana J. Wayne/Orange Cnty
$371

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 13, 2026.
Use the filters below to find and compare flights from Santa Ana to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Fri 4/24

6:45 am-10:51 pm

1 stop13h 06m

Knoxville McGhee Tyson

Sun 4/26

4:28 pm-10:44 am

1 stop21h 16m

$280

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Mon 8/24

8:55 am-7:37 pm

1 stop7h 42m

Knoxville McGhee Tyson

Sun 8/30

7:00 am-8:09 am

1 stop28h 09m

$299

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sun 8/16

1:50 pm-11:27 pm

1 stop6h 37m

Knoxville McGhee Tyson

Sun 8/30

7:00 am-8:09 am

1 stop28h 09m

$300

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sat 5/23

9:54 am-1:59 pm

1 stop25h 05m

Knoxville McGhee Tyson

Fri 5/29

6:00 am-3:38 pm

2 stops36h 38m

$321

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Mon 5/11

11:14 am-10:51 pm

1 stop8h 37m

Knoxville McGhee Tyson

Thu 5/14

1:14 pm-9:09 am

2 stops22h 55m

$322

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sun 8/16

1:50 pm-11:27 pm

1 stop6h 37m

Knoxville McGhee Tyson

Thu 8/27

7:00 am-8:09 am

1 stop28h 09m

$323

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Mon 5/11

11:14 am-10:51 pm

1 stop8h 37m

Knoxville McGhee Tyson

Mon 5/18

8:32 pm-9:05 pm

2 stops27h 33m

$324

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Mon 5/11

11:14 am-10:51 pm

1 stop8h 37m

Knoxville McGhee Tyson

Thu 5/14

1:14 pm-9:09 am

2 stops22h 55m

$325
Quickest round-trip

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Fri 5/1

7:56 pm-6:03 pm

2 stops19h 07m

Knoxville McGhee Tyson

Mon 5/4

1:43 pm-10:08 pm

1 stop11h 25m

$326

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 8/19

7:30 am-1:49 pm

2 stops27h 19m

Knoxville McGhee Tyson

Sun 8/30

7:00 am-8:09 am

1 stop28h 09m

$327

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Santa Ana to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santa Ana and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Santa Ana, with most prices found around $338. If you aren’t able to travel during the month of August, then book flights to Knoxville from Santa Ana during November instead. Flights to Knoxville in November, while not as cheap as those in August, still average around $362.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Santa Ana when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $458 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Santa Ana for as low as $288 on momondo.

Can stopping save me money on Santa Ana to Knoxville flights?

You could potentially save up to 19% on your flight if you consider stops on a Santa Ana to Knoxville flight.

How have Santa Ana to Knoxville flight prices changed over time?

As of April 2026, prices for Santa Ana to Knoxville flights are approximately 106% more expensive when compared to flights at the same time last year.

When to book flights from Santa Ana to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana to Knoxville (SNA to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana to Knoxville

Fastest flight time

6h 26m

Direct flights

None
The fastest flight from Santa Ana to Knoxville takes 6h 26m
There are no direct flights from Santa Ana to Knoxville. There are no popular flight routes from Santa Ana to Knoxville.
Search flight deals

Frequently asked questions about flying from Santa Ana to Knoxville

  • How far is Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson by plane?

    Santa Ana J. Wayne/Orange Cnty and Knoxville McGhee Tyson are 1919.8 mi apart from one another. 6h 26m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santa Ana to Knoxville?

Best airlines flying from Santa Ana to Knoxville

Compare and see reviews for airlines that fly from Santa Ana to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $174Free CancellationRating
7.9
8,406 reviews
Search Delta flights
United AirlinesPriceFrom $288Free CancellationRating
7.4
9,579 reviews
Search United Airlines flights
American AirlinesPriceFrom $288Free CancellationRating
7.1
11,569 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santa Ana to Knoxville for you.

Can I find flights from Santa Ana to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Santa Ana to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Santa Ana to Knoxville?

momondo helps you find the best flight between Santa Ana and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santa Ana to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Santa Ana to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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