Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Santa Ana to Knoxville from $154

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana to Knoxville departing on 5/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Santa Ana to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
2:39 pm - 3:33 pm
SNA
-
TYS
21h 54m
2 stops
Multiple Airlines Logo
1:43 pm - 9:45 pm
TYS
-
SNA
11h 02m
1 stop
$287Multiple Airlines
Sat, Apr 18 - Mon, Apr 27
American Airlines Logo
2:42 pm - 11:56 pm
SNA
-
TYS
6h 14m
1 stop
American Airlines Logo
6:54 pm - 10:45 pm
TYS
-
SNA
6h 51m
1 stop
$289American Airlines
Tue, Apr 21 - Sat, Apr 25
Multiple Airlines Logo
2:39 pm - 3:33 pm
SNA
-
TYS
21h 54m
2 stops
Multiple Airlines Logo
1:43 pm - 9:45 pm
TYS
-
SNA
11h 02m
1 stop
$290Multiple Airlines
Sat, Apr 18 - Mon, Apr 27
United Airlines Logo
12:15 pm - 11:41 pm
SNA
-
TYS
8h 26m
1 stop
United Airlines Logo
10:49 am - 5:33 pm
TYS
-
SNA
9h 44m
2 stops
$294United Airlines
Wed, Apr 8 - Tue, Apr 14
Frontier Logo
2:39 pm - 3:33 pm
SNA
-
TYS
21h 54m
2 stops
Frontier Logo
4:28 pm - 10:44 am
TYS
-
SNA
21h 16m
1 stop
$302Frontier
Sat, Apr 18 - Thu, Apr 23
United Airlines Logo
7:00 am - 7:56 pm
SNA
-
TYS
9h 56m
2 stops
United Airlines Logo
4:30 pm - 8:48 pm
TYS
-
SNA
7h 18m
1 stop
$320United Airlines
Tue, Apr 21 - Sat, Apr 25
Multiple Airlines Logo
7:48 pm - 10:51 pm
SNA
-
TYS
24h 03m
1 stop
Multiple Airlines Logo
1:43 pm - 9:45 pm
TYS
-
SNA
11h 02m
1 stop
$323Multiple Airlines
Sun, Apr 19 - Mon, Apr 27
Multiple Airlines Logo
3:23 pm - 10:51 pm
SNA
-
TYS
28h 28m
1 stop
Multiple Airlines Logo
1:43 pm - 9:45 pm
TYS
-
SNA
11h 02m
1 stop
$330Multiple Airlines
Thu, Apr 23 - Mon, Apr 27
Multiple Airlines Logo
3:23 pm - 10:51 pm
SNA
-
TYS
28h 28m
1 stop
Multiple Airlines Logo
1:43 pm - 9:45 pm
TYS
-
SNA
11h 02m
1 stop
$333Multiple Airlines
Thu, Apr 23 - Mon, Apr 27
Multiple Airlines Logo
9:00 am - 10:51 pm
SNA
-
TYS
10h 51m
1 stop
Multiple Airlines Logo
4:28 pm - 10:44 am
TYS
-
SNA
21h 16m
1 stop
$334Multiple Airlines
Mon, Apr 20 - Thu, Apr 23

American Airlines flights from Santa Ana to Knoxville

Our best American Airlines deals on Santa Ana to Knoxville flight tickets
American Airlines
Apr 21
SNA2:42 pmSanta Ana J. Wayne/Orange Cnty
6h 14m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
Apr 25
TYS6:54 pmKnoxville McGhee Tyson
6h 51m
1 stop
SNA10:45 pmSanta Ana J. Wayne/Orange Cnty
$289
American Airlines
Apr 15
SNA2:42 pmSanta Ana J. Wayne/Orange Cnty
6h 14m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
Apr 21
TYS6:00 amKnoxville McGhee Tyson
7h 08m
1 stop
SNA10:08 amSanta Ana J. Wayne/Orange Cnty
$359
American Airlines
Apr 22
SNA1:23 pmSanta Ana J. Wayne/Orange Cnty
7h 33m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
Apr 27
TYS6:54 pmKnoxville McGhee Tyson
6h 51m
1 stop
SNA10:45 pmSanta Ana J. Wayne/Orange Cnty
$363

United Airlines flights from Santa Ana to Knoxville

Our best United Airlines deals on Santa Ana to Knoxville flight tickets
United Airlines
Apr 8
SNA12:15 pmSanta Ana J. Wayne/Orange Cnty
8h 26m
1 stop
TYS11:41 pmKnoxville McGhee Tyson
Apr 14
TYS10:49 amKnoxville McGhee Tyson
9h 44m
2 stops
SNA5:33 pmSanta Ana J. Wayne/Orange Cnty
$294
United Airlines
Apr 21
SNA7:00 amSanta Ana J. Wayne/Orange Cnty
9h 56m
2 stops
TYS7:56 pmKnoxville McGhee Tyson
Apr 25
TYS4:30 pmKnoxville McGhee Tyson
7h 18m
1 stop
SNA8:48 pmSanta Ana J. Wayne/Orange Cnty
$320
United Airlines
Aug 22
SNA11:30 amSanta Ana J. Wayne/Orange Cnty
8h 49m
2 stops
TYS11:19 pmKnoxville McGhee Tyson
Aug 24
TYS7:00 amKnoxville McGhee Tyson
7h 17m
1 stop
SNA11:17 amSanta Ana J. Wayne/Orange Cnty
$368

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 1, 2026.
Use the filters below to find and compare flights from Santa Ana to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sat 4/18

2:39 pm-3:33 pm

2 stops21h 54m

Knoxville McGhee Tyson

Mon 4/27

1:43 pm-9:45 pm

1 stop11h 02m

$287

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Tue 4/21

2:42 pm-11:56 pm

1 stop6h 14m

Knoxville McGhee Tyson

Sat 4/25

6:54 pm-10:45 pm

1 stop6h 51m

$289

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sat 4/18

2:39 pm-3:33 pm

2 stops21h 54m

Knoxville McGhee Tyson

Mon 4/27

1:43 pm-9:45 pm

1 stop11h 02m

$290

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 4/8

12:15 pm-11:41 pm

1 stop8h 26m

Knoxville McGhee Tyson

Tue 4/14

10:49 am-5:33 pm

2 stops9h 44m

$294

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sat 4/18

2:39 pm-3:33 pm

2 stops21h 54m

Knoxville McGhee Tyson

Thu 4/23

4:28 pm-10:44 am

1 stop21h 16m

$302

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Tue 4/21

7:00 am-7:56 pm

2 stops9h 56m

Knoxville McGhee Tyson

Sat 4/25

4:30 pm-8:48 pm

1 stop7h 18m

$320

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sun 4/19

7:48 pm-10:51 pm

1 stop24h 03m

Knoxville McGhee Tyson

Mon 4/27

1:43 pm-9:45 pm

1 stop11h 02m

$323

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 4/23

3:23 pm-10:51 pm

1 stop28h 28m

Knoxville McGhee Tyson

Mon 4/27

1:43 pm-9:45 pm

1 stop11h 02m

$330

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Thu 4/23

3:23 pm-10:51 pm

1 stop28h 28m

Knoxville McGhee Tyson

Mon 4/27

1:43 pm-9:45 pm

1 stop11h 02m

$333

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Mon 4/20

9:00 am-10:51 pm

1 stop10h 51m

Knoxville McGhee Tyson

Thu 4/23

4:28 pm-10:44 am

1 stop21h 16m

$334

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Knoxville from

How to get the cheapest flight ticket from Santa Ana to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Santa Ana, California, with most prices found around $338. If you aren’t able to travel during the month of August, then book flights to Knoxville from Santa Ana, California during November instead. Flights to Knoxville in November, while not as cheap as those in August, still average around $362.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Santa Ana, California when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $440 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Santa Ana, California for as low as $257 on momondo.

Can stopping save me money on Santa Ana, California to Knoxville flights?

You could potentially save up to 31% on your flight if you consider stops on a Santa Ana, California to Knoxville flight.

How have Santa Ana, California to Knoxville flight prices changed over time?

As of March 2026, prices for Santa Ana, California to Knoxville flights are approximately 83% more expensive when compared to flights at the same time last year.

When to book flights from Santa Ana to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana to Knoxville (SNA to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana to Knoxville

Fastest flight time

6h 46m

Direct flights

None
The fastest flight from Santa Ana, California to Knoxville takes 6h 46m
There are no direct flights from Santa Ana, California to Knoxville. There are no popular flight routes from Santa Ana, California to Knoxville.
Search flight deals

  • How far is Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson by plane?

    Santa Ana J. Wayne/Orange Cnty and Knoxville McGhee Tyson are 1919.8 mi apart from one another. 6h 46m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santa Ana, California to Knoxville?

Best airlines flying from Santa Ana to Knoxville

Compare and see reviews for airlines that fly from Santa Ana to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $174Free CancellationRating
7.9
8,244 reviews
Search Delta flights
United AirlinesPriceFrom $239Free CancellationRating
7.4
9,370 reviews
Search United Airlines flights
American AirlinesPriceFrom $258Free CancellationRating
7.1
11,370 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Alcoa
Crossville
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santa Ana to Knoxville for you.

Can I find flights from Santa Ana to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Santa Ana to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Santa Ana to Knoxville?

momondo helps you find the best flight between Santa Ana and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santa Ana to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Santa Ana to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

An easier way to manage your Knoxville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Tue 3/31
Tue 4/7
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States