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Cheap flights from Santa Ana, California to Knoxville from $149

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana, California to Knoxville departing on 8/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Santa Ana, California to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:53 pm - 7:24 pm
SNA
-
TYS
20h 31m
2 stops
Multiple Airlines Logo
7:00 am - 8:15 am
TYS
-
SNA
28h 15m
1 stop
$283Multiple Airlines
Sun, Aug 9 - Sun, Aug 16
Multiple Airlines Logo
6:03 pm - 11:12 pm
SNA
-
TYS
26h 09m
2 stops
Multiple Airlines Logo
2:39 pm - 1:42 pm
TYS
-
SNA
26h 03m
1 stop
$284Multiple Airlines
Sun, Aug 16 - Sun, Aug 23
United Airlines Logo
6:45 am - 3:54 pm
SNA
-
TYS
6h 09m
1 stop
United Airlines Logo
4:50 pm - 8:39 pm
TYS
-
SNA
6h 49m
1 stop
$293United Airlines
Tue, Aug 11 - Sat, Sep 5
United Airlines Logo
6:45 am - 3:54 pm
SNA
-
TYS
6h 09m
1 stop
United Airlines Logo
9:45 am - 5:29 pm
TYS
-
SNA
10h 44m
2 stops
$298United Airlines
Tue, Aug 11 - Sat, Sep 5
Multiple Airlines Logo
7:53 pm - 10:03 pm
SNA
-
TYS
23h 10m
2 stops
Multiple Airlines Logo
2:47 pm - 12:31 pm
TYS
-
SNA
24h 44m
1 stop
$310Multiple Airlines
Fri, Aug 7 - Fri, Aug 14
Southwest Logo
7:45 pm - 12:05 pm
SNA
-
TYS
13h 20m
2 stops
Southwest Logo
1:55 pm - 7:50 pm
TYS
-
SNA
8h 55m
2 stops
$311Southwest
Mon, Aug 10 - Sat, Sep 5
Multiple Airlines Logo
7:30 am - 8:52 pm
SNA
-
TYS
10h 22m
1 stop
Multiple Airlines Logo
12:29 pm - 1:32 pm
TYS
-
SNA
28h 03m
1 stop
$320Multiple Airlines
Mon, Nov 2 - Sun, Nov 8
Multiple Airlines Logo
11:15 am - 7:24 pm
SNA
-
TYS
29h 09m
1 stop
Multiple Airlines Logo
7:00 am - 8:15 am
TYS
-
SNA
28h 15m
1 stop
$321Multiple Airlines
Sun, Aug 9 - Sun, Aug 16
Delta Logo
2:00 pm - 11:55 pm
SNA
-
TYS
6h 55m
1 stop
Delta Logo
5:45 pm - 10:29 pm
TYS
-
SNA
7h 44m
1 stop
$326Delta
Fri, Sep 18 - Sat, Sep 26
Multiple Airlines Logo
7:30 am - 1:49 pm
SNA
-
TYS
27h 19m
2 stops
Multiple Airlines Logo
12:54 pm - 3:01 pm
TYS
-
SNA
29h 07m
1 stop
$327Multiple Airlines
Wed, Aug 19 - Mon, Aug 24

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American Airlines flights from Santa Ana, California to Knoxville

Our best American Airlines deals on Santa Ana, California to Knoxville flight tickets
American Airlines
Sep 12
SNA6:45 amSanta Ana J. Wayne/Orange Cnty
6h 57m
1 stop
TYS4:42 pmKnoxville McGhee Tyson
Sep 16
TYS6:00 amKnoxville McGhee Tyson
6h 45m
1 stop
SNA9:45 amSanta Ana J. Wayne/Orange Cnty
$355
American Airlines
Sep 16
SNA1:40 pmSanta Ana J. Wayne/Orange Cnty
6h 42m
1 stop
TYS11:22 pmKnoxville McGhee Tyson
Oct 2
TYS6:00 amKnoxville McGhee Tyson
6h 45m
1 stop
SNA9:45 amSanta Ana J. Wayne/Orange Cnty
$426
American Airlines
Jul 22
SNA10:25 amSanta Ana J. Wayne/Orange Cnty
8h 34m
1 stop
TYS9:59 pmKnoxville McGhee Tyson
Jul 26
TYS5:37 amKnoxville McGhee Tyson
6h 56m
1 stop
SNA9:33 amSanta Ana J. Wayne/Orange Cnty
$749

United Airlines flights from Santa Ana, California to Knoxville

Our best United Airlines deals on Santa Ana, California to Knoxville flight tickets
United Airlines
Aug 11
SNA6:45 amSanta Ana J. Wayne/Orange Cnty
6h 09m
1 stop
TYS3:54 pmKnoxville McGhee Tyson
Sep 5
TYS4:50 pmKnoxville McGhee Tyson
6h 49m
1 stop
SNA8:39 pmSanta Ana J. Wayne/Orange Cnty
$293
United Airlines
Aug 11
SNA6:45 amSanta Ana J. Wayne/Orange Cnty
6h 09m
1 stop
TYS3:54 pmKnoxville McGhee Tyson
Sep 5
TYS9:45 amKnoxville McGhee Tyson
10h 44m
2 stops
SNA5:29 pmSanta Ana J. Wayne/Orange Cnty
$298
United Airlines
Aug 12
SNA6:45 amSanta Ana J. Wayne/Orange Cnty
6h 09m
1 stop
TYS3:54 pmKnoxville McGhee Tyson
Aug 19
TYS7:00 amKnoxville McGhee Tyson
9h 53m
2 stops
SNA1:53 pmSanta Ana J. Wayne/Orange Cnty
$360

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana, California to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 15, 2026.
Use the filters below to find and compare flights from Santa Ana, California to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sun 8/9

7:53 pm-7:24 pm

2 stops20h 31m

Knoxville McGhee Tyson

Sun 8/16

7:00 am-8:15 am

1 stop28h 15m

$283

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sun 8/16

6:03 pm-11:12 pm

2 stops26h 09m

Knoxville McGhee Tyson

Sun 8/23

2:39 pm-1:42 pm

1 stop26h 03m

$284
Quickest round-trip

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Tue 8/11

6:45 am-3:54 pm

1 stop6h 09m

Knoxville McGhee Tyson

Sat 9/5

4:50 pm-8:39 pm

1 stop6h 49m

$293

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Tue 8/11

6:45 am-3:54 pm

1 stop6h 09m

Knoxville McGhee Tyson

Sat 9/5

9:45 am-5:29 pm

2 stops10h 44m

$298

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Fri 8/7

7:53 pm-10:03 pm

2 stops23h 10m

Knoxville McGhee Tyson

Fri 8/14

2:47 pm-12:31 pm

1 stop24h 44m

$310

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Mon 8/10

7:45 pm-12:05 pm

2 stops13h 20m

Knoxville McGhee Tyson

Sat 9/5

1:55 pm-7:50 pm

2 stops8h 55m

$311

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Mon 11/2

7:30 am-8:52 pm

1 stop10h 22m

Knoxville McGhee Tyson

Sun 11/8

12:29 pm-1:32 pm

1 stop28h 03m

$320

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Sun 8/9

11:15 am-7:24 pm

1 stop29h 09m

Knoxville McGhee Tyson

Sun 8/16

7:00 am-8:15 am

1 stop28h 15m

$321

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Fri 9/18

2:00 pm-11:55 pm

1 stop6h 55m

Knoxville McGhee Tyson

Sat 9/26

5:45 pm-10:29 pm

1 stop7h 44m

$326

Santa AnaKnoxville

SNA - TYS

SNATYS

Santa Ana J. Wayne/Orange Cnty

Wed 8/19

7:30 am-1:49 pm

2 stops27h 19m

Knoxville McGhee Tyson

Mon 8/24

12:54 pm-3:01 pm

1 stop29h 07m

$327

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Santa Ana, California to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santa Ana, California and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of November is, on average, the cheapest month to fly to Knoxville from Santa Ana, California, with most prices found around $362. If you aren’t able to travel during the month of November, then book flights to Knoxville from Santa Ana, California during August instead. Flights to Knoxville in August, while not as cheap as those in November, still average around $384.

How far in advance should I book a flight from Santa Ana, California to Knoxville?

You are more likely to see cheaper flights to Knoxville from Santa Ana, California when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $500 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Santa Ana, California for as low as $381 on momondo.

Can stopping save me money on Santa Ana, California to Knoxville flights?

You could potentially save up to 40% on your flight if you consider stops on a Santa Ana, California to Knoxville flight.

How have Santa Ana, California to Knoxville flight prices changed over time?

As of July 2026, prices for Santa Ana, California to Knoxville flights are approximately 35% cheaper when compared to flights at the same time last year.

When to book flights from Santa Ana, California to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana, California to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana, California to Knoxville (SNA to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana, California to Knoxville

Fastest flight time

6h 08m

Direct flights

None
The fastest flight from Santa Ana, California to Knoxville takes 6h 08m
There are no direct flights from Santa Ana, California to Knoxville. There are no popular flight routes from Santa Ana, California to Knoxville.
Search flight deals

Frequently asked questions about flying from Santa Ana, California to Knoxville

  • How far is Santa Ana J. Wayne/Orange Cnty to Knoxville McGhee Tyson by plane?

    Santa Ana J. Wayne/Orange Cnty and Knoxville McGhee Tyson are 1919.8 mi apart from one another. 6h 08m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santa Ana, California to Knoxville?

Best airlines flying from Santa Ana, California to Knoxville

Compare and see reviews for airlines that fly from Santa Ana, California to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $174Free CancellationRating
7.8
8,469 reviews
Search Delta flights
United AirlinesPriceFrom $288Free CancellationRating
7.4
9,988 reviews
Search United Airlines flights
American AirlinesPriceFrom $288Free CancellationRating
7.1
11,806 reviews
Search American Airlines flights
SouthwestPriceFrom $412Free CancellationRating
8.0
4,244 reviews
Search Southwest flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Alcoa
Murphy
Crossville
Oak Ridge
Kodak
Newport
Lenoir City
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santa Ana to Knoxville for you.

Can I find flights from Santa Ana to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Santa Ana to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Santa Ana to Knoxville?

momondo helps you find the best flight between Santa Ana and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santa Ana to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Santa Ana to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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