Cheap flights from San Francisco to Indianapolis from $169

In general, September is the cheapest month to fly from San Francisco to Indianapolis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $358. If you are unable to visit Indianapolis during the month of September, then departing from San Francisco during the month January is also very affordable. Most momondo users find prices during this month for around $359.

Our data shows that Saturday is the least expensive day to fly to Indianapolis. Tickets to fly out on this day can be as low as $382. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Indianapolis on Sunday is $484.

Flying to Indianapolis from San Francisco in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $367 when looking at flights departing in the afternoon. If you have a flexible travel schedule, then try to avoid flying in the morning when prices are $495 on average. Flights to Indianapolis from San Francisco in the morning are generally more expensive because this time of day is more convenient for travelers’ schedules.

Fly from San Francisco to Indianapolis for the best San Francisco - Indianapolis flight prices

You are more likely to see cheaper flights to Indianapolis from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Indianapolis for around $397 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Indianapolis from San Francisco for as low as $314 on momondo.

There are 4 cabin classes available to choose from on San Francisco to Indianapolis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Southwest and Alaska Airlines are the most popular carriers operating from San Francisco to Indianapolis

United Airlines, Delta and American Airlines are the top three most popular airlines that fly to Indianapolis from San Francisco according to our data. United Airlines is the first choice among our users, with 45% of people opting to fly with this airline when traveling to Indianapolis. Keep in mind that there are 8 different airlines that fly to Indianapolis on a routine basis, so you have a few additional options to choose from.

Historically, on average around 21% of flights between San Francisco and Indianapolis have experienced a delay on any given week. The average delay length over the past 12 months has been 161 minutes.

Generally, flights departing in the early afternoon tend to experience fewer delays. Flights in the evening have, in the past, seen delays more frequently in comparison.

Friday is statistically the day of the week which experiences the fewest number of delays on this flight route. Sunday has historically seen more delays on average compared to the rest of the week.

According to our data, United Airlines have had the least number of delays on this route over the last 12 months; with about 13% of their flights experiencing any sort of delay.

Los Angeles (LAX) was the most common stop: 36% of momondo users choosing 1-stop flights on this route connected there.

Flights via Chicago (ORD) offer the lowest average round-trip price of $210.

Flights connecting via Las Vegas (LAS) have the shortest average one-way travel time: 6h 10m.

Chicago (ORD) has the shortest average layover time for this route: 0h 52m.

As of March 2026, there are 2 flights per day flying from San Francisco to Indianapolis. The most common time of day flights depart is 1:00PM, with 100% of flights taking off in the afternoon.

As of March 2026, 15 flights take off from San Francisco and land in Indianapolis each week. The most common flight departure day for this route is Mon, with 20% of weekly flights taking off on this day.