Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from San Francisco to Greenville from $173

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Greenville departing on 4/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from San Francisco to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
5:55 am - 5:45 pm
SFO
-
GSP
8h 50m
2 stops
Southwest Logo
1:55 pm - 10:10 pm
GSP
-
SFO
11h 15m
2 stops
$377Southwest
Wed, Apr 1 - Wed, Apr 8
Southwest Logo
8:30 am - 10:40 pm
SFO
-
GSP
11h 10m
2 stops
Southwest Logo
12:50 pm - 8:55 pm
GSP
-
SFO
11h 05m
1 stop
$378Southwest
Wed, Apr 1 - Wed, Apr 8
United Airlines Logo
5:00 am - 3:36 pm
SFO
-
GSP
7h 36m
1 stop
United Airlines Logo
6:12 am - 1:38 pm
GSP
-
SFO
10h 26m
1 stop
$380United Airlines
Wed, Feb 18 - Thu, Feb 19
American Airlines Logo
12:30 am - 1:15 pm
SFO
-
GSP
9h 45m
2 stops
American Airlines Logo
2:19 pm - 8:56 pm
GSP
-
SFO
9h 37m
1 stop
$392American Airlines
Tue, Feb 17 - Thu, Feb 19
American Airlines Logo
11:29 pm - 10:56 am
SFO
-
GSP
8h 27m
1 stop
American Airlines Logo
5:12 pm - 9:57 pm
GSP
-
SFO
7h 45m
1 stop
$393American Airlines
Wed, Apr 1 - Wed, Apr 8
Southwest Logo
9:30 pm - 10:10 am
SFO
-
GSP
9h 40m
1 stop
Southwest Logo
8:20 am - 5:40 pm
GSP
-
SFO
12h 20m
2 stops
$398Southwest
Thu, Feb 26 - Mon, Mar 2
Southwest Logo
8:25 am - 9:45 pm
SFO
-
GSP
10h 20m
2 stops
Southwest Logo
8:20 am - 5:40 pm
GSP
-
SFO
12h 20m
2 stops
$403Southwest
Thu, Feb 26 - Mon, Mar 2
Delta Logo
8:00 am - 6:37 pm
SFO
-
GSP
7h 37m
1 stop
Delta Logo
7:59 pm - 12:35 am
GSP
-
SFO
7h 36m
1 stop
$407Delta
Tue, Mar 3 - Sun, Mar 8
American Airlines Logo
10:36 am - 11:42 pm
SFO
-
GSP
10h 06m
1 stop
American Airlines Logo
4:26 pm - 11:10 pm
GSP
-
SFO
9h 44m
1 stop
$409American Airlines
Thu, Feb 26 - Mon, Mar 2
Delta Logo
5:45 am - 5:59 pm
SFO
-
GSP
9h 14m
1 stop
Delta Logo
7:59 pm - 12:35 am
GSP
-
SFO
7h 36m
1 stop
$412Delta
Tue, Mar 3 - Sun, Mar 8

Southwest flights from San Francisco to Greenville

Our best Southwest deals on San Francisco to Greenville flight tickets
Southwest
Apr 1
SFO5:55 amSan Francisco
8h 50m
2 stops
GSP5:45 pmGreenville
Apr 8
GSP1:55 pmGreenville
11h 15m
2 stops
SFO10:10 pmSan Francisco
$377
Southwest
Apr 1
SFO8:30 amSan Francisco
11h 10m
2 stops
GSP10:40 pmGreenville
Apr 8
GSP12:50 pmGreenville
11h 05m
1 stop
SFO8:55 pmSan Francisco
$378
Southwest
Feb 26
SFO9:30 pmSan Francisco
9h 40m
1 stop
GSP10:10 amGreenville
Mar 2
GSP8:20 amGreenville
12h 20m
2 stops
SFO5:40 pmSan Francisco
$398

American Airlines flights from San Francisco to Greenville

Our best American Airlines deals on San Francisco to Greenville flight tickets
American Airlines
Feb 17
SFO12:30 amSan Francisco
9h 45m
2 stops
GSP1:15 pmGreenville
Feb 19
GSP2:19 pmGreenville
9h 37m
1 stop
SFO8:56 pmSan Francisco
$392
American Airlines
Apr 1
SFO11:29 pmSan Francisco
8h 27m
1 stop
GSP10:56 amGreenville
Apr 8
GSP5:12 pmGreenville
7h 45m
1 stop
SFO9:57 pmSan Francisco
$393
American Airlines
Feb 26
SFO10:36 amSan Francisco
10h 06m
1 stop
GSP11:42 pmGreenville
Mar 2
GSP4:26 pmGreenville
9h 44m
1 stop
SFO11:10 pmSan Francisco
$409

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from San Francisco to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Wed 4/1

5:55 am-5:45 pm

2 stops8h 50m

Greenville

Wed 4/8

1:55 pm-10:10 pm

2 stops11h 15m

$377

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Wed 4/1

8:30 am-10:40 pm

2 stops11h 10m

Greenville

Wed 4/8

12:50 pm-8:55 pm

1 stop11h 05m

$378

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Wed 2/18

5:00 am-3:36 pm

1 stop7h 36m

Greenville

Thu 2/19

6:12 am-1:38 pm

1 stop10h 26m

$380

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Tue 2/17

12:30 am-1:15 pm

2 stops9h 45m

Greenville

Thu 2/19

2:19 pm-8:56 pm

1 stop9h 37m

$392

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Wed 4/1

11:29 pm-10:56 am

1 stop8h 27m

Greenville

Wed 4/8

5:12 pm-9:57 pm

1 stop7h 45m

$393

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Thu 2/26

9:30 pm-10:10 am

1 stop9h 40m

Greenville

Mon 3/2

8:20 am-5:40 pm

2 stops12h 20m

$398

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Thu 2/26

8:25 am-9:45 pm

2 stops10h 20m

Greenville

Mon 3/2

8:20 am-5:40 pm

2 stops12h 20m

$403

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Tue 3/3

8:00 am-6:37 pm

1 stop7h 37m

Greenville

Sun 3/8

7:59 pm-12:35 am

1 stop7h 36m

$407

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Thu 2/26

10:36 am-11:42 pm

1 stop10h 06m

Greenville

Mon 3/2

4:26 pm-11:10 pm

1 stop9h 44m

$409

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Tue 3/3

5:45 am-5:59 pm

1 stop9h 14m

Greenville

Sun 3/8

7:59 pm-12:35 am

1 stop7h 36m

$412

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Greenville from

How to get the cheapest flight ticket from San Francisco to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Greenville?

The month of September is another great option to travel to Greenville, with average flight prices from San Francisco averaging around $410.

How far in advance should I book a flight to Greenville?

You are more likely to see cheaper flights to Greenville from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Greenville for around $473 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Greenville from San Francisco for as low as $358 on momondo.

How have San Francisco to Greenville flight prices changed over time?

As of January 2026, prices for San Francisco to Greenville flights are approximately 14% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Greenville (SFO to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Greenville

Fastest flight time

6h 34m

Direct flights

None
The fastest flight from San Francisco to Greenville takes 6h 34m
There are no direct flights from San Francisco to Greenville. There are no popular flight routes from San Francisco to Greenville.
Search flight deals

  • How far is San Francisco to Greenville by plane?

    The straight-line distance from San Francisco to Greenville is 2218.5 mi. Flights usually cover this in 6h 34m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from San Francisco Airport to Greenville Airport?

    Prices for flights from San Francisco Airport to Greenville Airport refresh daily.

  • How many operators does momondo search for flights from San Francisco Airport to Greenville Airport?

  • How old do you have to be to fly from San Francisco Airport to Greenville Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Francisco Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The required travel and health documents for your Greenville Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Greenville Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Francisco to Greenville?

Best airlines flying from San Francisco to Greenville

Compare and see reviews for airlines that fly from San Francisco to Greenville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $236Free CancellationRating
7.2
11,205 reviews
Search American Airlines flights
DeltaPriceFrom $278Free CancellationRating
7.9
8,128 reviews
Search Delta flights
SouthwestPriceFrom $313Free CancellationRating
8.0
4,267 reviews
Search Southwest flights
United AirlinesPriceFrom $424Free CancellationRating
7.4
9,215 reviews
Search United Airlines flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Seneca
Greer
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Greenville?

It is quick and easy to find San Francisco to Greenville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Greenville that suits you.

Can I find flights from San Francisco to Greenville with flexible booking policies on momondo?

All flight searches from San Francisco to Greenville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from San Francisco to Greenville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Greenville from San Francisco.

I’m not ready to book a flight from San Francisco to Greenville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from San Francisco to Greenville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Greenville and let you know when they change.

An easier way to manage your Greenville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sat 2/28
Sat 3/7
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States