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Cheap flights from San Francisco to Greenville from $157

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Greenville departing on 1/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Francisco to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
6:45 am - 4:52 pmSFO-GSP
7h 07m1 stop
United Airlines Logo
10:00 am - 5:19 pmGSP-SFO
10h 19m1 stop
$363United Airlines
Find Deal
Wed, Jan 14 - Sun, Jan 18
American Airlines Logo
6:00 am - 3:50 pmSFO-GSP
6h 50m1 stop
American Airlines Logo
12:09 pm - 7:19 pmGSP-SFO
10h 10m2 stops
$368American Airlines
Find Deal
Wed, Jan 14 - Sun, Jan 18
American Airlines Logo
11:59 pm - 11:37 amSFO-GSP
8h 38m2 stops
American Airlines Logo
11:33 am - 5:51 pmGSP-SFO
9h 18m1 stop
$372American Airlines
Find Deal
Tue, Dec 9 - Thu, Dec 11
Southwest Logo
9:25 pm - 10:00 amSFO-GSP
9h 35m1 stop
Southwest Logo
7:40 am - 1:20 pmGSP-SFO
8h 40m1 stop
$373Southwest
Find Deal
Tue, Dec 9 - Thu, Dec 11
Southwest Logo
4:30 pm - 10:00 amSFO-GSP
14h 30m2 stops
Southwest Logo
3:05 pm - 9:20 pmGSP-SFO
9h 15m2 stops
$383Southwest
Find Deal
Tue, Dec 9 - Thu, Dec 11
American Airlines Logo
6:00 am - 3:33 pmSFO-GSP
6h 33m1 stop
American Airlines Logo
5:40 pm - 10:25 pmGSP-SFO
7h 45m1 stop
$412American Airlines
Find Deal
Sat, Jan 3 - Sat, Jan 10
Delta Logo
11:45 pm - 9:21 amSFO-GSP
6h 36m1 stop
Delta Logo
6:50 am - 12:55 pmGSP-SFO
9h 05m1 stop
$413Delta
Find Deal
Sun, Jan 4 - Thu, Jan 8
Southwest Logo
9:30 pm - 10:10 amSFO-GSP
9h 40m1 stop
Southwest Logo
12:30 pm - 10:15 pmGSP-SFO
12h 45m2 stops
$414Southwest
Find Deal
Sun, Feb 15 - Mon, Feb 23
United Airlines Logo
5:10 am - 3:15 pmSFO-GSP
7h 05m1 stop
United Airlines Logo
2:51 pm - 9:06 pmGSP-SFO
9h 15m1 stop
$432United Airlines
Find Deal
Sun, Feb 15 - Mon, Feb 23
Delta Logo
9:30 pm - 9:02 amSFO-GSP
8h 32m1 stop
Delta Logo
5:35 am - 12:36 pmGSP-SFO
10h 01m1 stop
$443Delta
Find Deal
Mon, Nov 24 - Wed, Dec 3

United Airlines flights from San Francisco to Greenville

Our best United Airlines deals on San Francisco to Greenville flight tickets
United Airlines
Jan 14
SFO6:45 amSan Francisco
7h 07m
1 stop
GSP4:52 pmGreenville
Jan 18
GSP10:00 amGreenville
10h 19m
1 stop
SFO5:19 pmSan Francisco
$363
Find similar
United Airlines
Feb 15
SFO5:10 amSan Francisco
7h 05m
1 stop
GSP3:15 pmGreenville
Feb 23
GSP2:51 pmGreenville
9h 15m
1 stop
SFO9:06 pmSan Francisco
$432
Find similar
United Airlines
Jan 31
SFO11:15 pmSan Francisco
8h 01m
1 stop
GSP10:16 amGreenville
Feb 8
GSP6:40 amGreenville
8h 40m
1 stop
SFO12:20 pmSan Francisco
$512
Find similar

American Airlines flights from San Francisco to Greenville

Our best American Airlines deals on San Francisco to Greenville flight tickets
American Airlines
Jan 14
SFO6:00 amSan Francisco
6h 50m
1 stop
GSP3:50 pmGreenville
Jan 18
GSP12:09 pmGreenville
10h 10m
2 stops
SFO7:19 pmSan Francisco
$368
Find similar
American Airlines
Dec 9
SFO11:59 pmSan Francisco
8h 38m
2 stops
GSP11:37 amGreenville
Dec 11
GSP11:33 amGreenville
9h 18m
1 stop
SFO5:51 pmSan Francisco
$372
Find similar
American Airlines
Jan 3
SFO6:00 amSan Francisco
6h 33m
1 stop
GSP3:33 pmGreenville
Jan 10
GSP5:40 pmGreenville
7h 45m
1 stop
SFO10:25 pmSan Francisco
$412
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from San Francisco to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Wed 1/14

6:45 am-4:52 pm

1 stop7h 07m

Greenville

Sun 1/18

10:00 am-5:19 pm

1 stop10h 19m

$363

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Wed 1/14

6:00 am-3:50 pm

1 stop6h 50m

Greenville

Sun 1/18

12:09 pm-7:19 pm

2 stops10h 10m

$368

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Tue 12/9

11:59 pm-11:37 am

2 stops8h 38m

Greenville

Thu 12/11

11:33 am-5:51 pm

1 stop9h 18m

$372

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Tue 12/9

9:25 pm-10:00 am

1 stop9h 35m

Greenville

Thu 12/11

7:40 am-1:20 pm

1 stop8h 40m

$373

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Tue 12/9

4:30 pm-10:00 am

2 stops14h 30m

Greenville

Thu 12/11

3:05 pm-9:20 pm

2 stops9h 15m

$383

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Sat 1/3

6:00 am-3:33 pm

1 stop6h 33m

Greenville

Sat 1/10

5:40 pm-10:25 pm

1 stop7h 45m

$412

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Sun 1/4

11:45 pm-9:21 am

1 stop6h 36m

Greenville

Thu 1/8

6:50 am-12:55 pm

1 stop9h 05m

$413

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Sun 2/15

9:30 pm-10:10 am

1 stop9h 40m

Greenville

Mon 2/23

12:30 pm-10:15 pm

2 stops12h 45m

$414

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Sun 2/15

5:10 am-3:15 pm

1 stop7h 05m

Greenville

Mon 2/23

2:51 pm-9:06 pm

1 stop9h 15m

$432

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Mon 11/24

9:30 pm-9:02 am

1 stop8h 32m

Greenville

Wed 12/3

5:35 am-12:36 pm

1 stop10h 01m

$443

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from San Francisco to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Greenville?

The month of April is another great option to travel to Greenville, with average flight prices from San Francisco averaging around $408.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Saturday is the cheapest day to fly to Greenville from San Francisco. The lowest ticket price found for a Saturday departure recently was $393. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $714. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the morning. Flights from San Francisco to Greenville during this time can be as low as $512. Flights to Greenville are more costly at noon, with an average ticket price of $545. Departure times at noon fall within the peak daily travel times, which is why tickets can be more expensive.

How far in advance should I book a flight to Greenville?

You are more likely to see cheaper flights to Greenville from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Greenville for around $474 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Greenville from San Francisco for as low as $221 on momondo.

How have San Francisco to Greenville flight prices changed over time?

As of November 2025, prices for San Francisco to Greenville flights are approximately 29% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Greenville (SFO to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Greenville

Direct flights

None
There are no direct flights from San Francisco to Greenville. There are no popular flight routes from San Francisco to Greenville.
Search flight deals

  • How far is San Francisco to Greenville by plane?

    The straight-line distance from San Francisco to Greenville is 2218.5 mi. Flights usually cover this in 6h 33m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from San Francisco Airport to Greenville Airport?

    Prices for flights from San Francisco Airport to Greenville Airport refresh daily.

  • How many operators does momondo search for flights from San Francisco Airport to Greenville Airport?

  • How old do you have to be to fly from San Francisco Airport to Greenville Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Francisco Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The required travel and health documents for your Greenville Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Greenville Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Francisco to Greenville?

Best airlines flying from San Francisco to Greenville

Compare and see reviews for airlines that fly from San Francisco to Greenville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $236Free CancellationRating
7.2
11,038 reviews
Search American Airlines flights
DeltaPriceFrom $278Free CancellationRating
7.9
8,002 reviews
Search Delta flights
SouthwestPriceFrom $313Free CancellationRating
8.0
4,238 reviews
Search Southwest flights
United AirlinesPriceFrom $506Free CancellationRating
7.4
8,997 reviews
Search United Airlines flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Seneca
Greer
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Greenville?

It is quick and easy to find San Francisco to Greenville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Greenville that suits you.

Can I find flights from San Francisco to Greenville with flexible booking policies on momondo?

All flight searches from San Francisco to Greenville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from San Francisco to Greenville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Greenville from San Francisco.

I’m not ready to book a flight from San Francisco to Greenville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from San Francisco to Greenville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Greenville and let you know when they change.

An easier way to manage your Greenville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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