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Cheap flights from San Francisco to Greenville from $184

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Greenville departing on 4/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from San Francisco to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
10:50 pm - 9:46 am
SFO
-
GSP
7h 56m
1 stop
United Airlines Logo
7:42 pm - 1:17 am
GSP
-
SFO
8h 35m
1 stop
$383United Airlines
Wed, Apr 15 - Tue, Apr 21
Multiple Airlines Logo
8:30 pm - 8:40 pm
SFO
-
GSP
21h 10m
1 stop
Multiple Airlines Logo
6:19 pm - 12:02 pm
GSP
-
SFO
20h 43m
1 stop
$386Multiple Airlines
Sun, Aug 23 - Mon, Aug 31
Southwest Logo
7:40 am - 9:40 pm
SFO
-
GSP
11h 00m
2 stops
Southwest Logo
1:55 pm - 9:25 pm
GSP
-
SFO
10h 30m
1 stop
$388Southwest
Wed, Apr 15 - Tue, Apr 21
American Airlines Logo
9:52 pm - 8:18 am
SFO
-
GSP
7h 26m
1 stop
American Airlines Logo
7:54 pm - 12:48 am
GSP
-
SFO
7h 54m
1 stop
$391American Airlines
Sat, May 23 - Wed, May 27
Southwest Logo
8:55 am - 9:40 pm
SFO
-
GSP
9h 45m
2 stops
Southwest Logo
12:50 pm - 10:05 pm
GSP
-
SFO
12h 15m
2 stops
$393Southwest
Wed, Apr 15 - Tue, Apr 21
Multiple Airlines Logo
8:30 pm - 8:40 pm
SFO
-
GSP
21h 10m
1 stop
Multiple Airlines Logo
8:28 pm - 9:00 pm
GSP
-
SFO
27h 32m
2 stops
$398Multiple Airlines
Sun, Aug 23 - Mon, Aug 31
United Airlines Logo
5:00 am - 3:54 pm
SFO
-
GSP
7h 54m
1 stop
United Airlines Logo
5:41 pm - 10:45 pm
GSP
-
SFO
8h 04m
1 stop
$399United Airlines
Sat, Apr 18 - Sat, Apr 25
Southwest Logo
5:40 am - 8:40 pm
SFO
-
GSP
12h 00m
2 stops
Southwest Logo
8:00 am - 2:25 pm
GSP
-
SFO
9h 25m
1 stop
$404Southwest
Sat, Apr 18 - Sat, Apr 25
Southwest Logo
10:30 am - 10:15 pm
SFO
-
GSP
8h 45m
2 stops
Southwest Logo
6:25 pm - 12:20 am
GSP
-
SFO
8h 55m
2 stops
$409Southwest
Thu, Apr 16 - Mon, Apr 20
American Airlines Logo
9:52 pm - 10:08 am
SFO
-
GSP
9h 16m
1 stop
American Airlines Logo
6:41 pm - 11:47 pm
GSP
-
SFO
8h 06m
1 stop
$415American Airlines
Sat, May 23 - Tue, May 26

United Airlines flights from San Francisco to Greenville

Our best United Airlines deals on San Francisco to Greenville flight tickets
United Airlines
Apr 15
SFO10:50 pmSan Francisco
7h 56m
1 stop
GSP9:46 amGreenville
Apr 21
GSP7:42 pmGreenville
8h 35m
1 stop
SFO1:17 amSan Francisco
$383
United Airlines
Apr 18
SFO5:00 amSan Francisco
7h 54m
1 stop
GSP3:54 pmGreenville
Apr 25
GSP5:41 pmGreenville
8h 04m
1 stop
SFO10:45 pmSan Francisco
$399
United Airlines
Apr 14
SFO8:45 amSan Francisco
11h 00m
1 stop
GSP10:45 pmGreenville
Apr 15
GSP6:30 amGreenville
9h 42m
1 stop
SFO1:12 pmSan Francisco
$493

Southwest flights from San Francisco to Greenville

Our best Southwest deals on San Francisco to Greenville flight tickets
Southwest
Apr 15
SFO7:20 amSan Francisco
11h 20m
2 stops
GSP9:40 pmGreenville
Apr 21
GSP1:55 pmGreenville
10h 30m
1 stop
SFO9:25 pmSan Francisco
$388
Southwest
Apr 15
SFO8:55 amSan Francisco
9h 45m
2 stops
GSP9:40 pmGreenville
Apr 21
GSP6:45 amGreenville
11h 35m
2 stops
SFO3:20 pmSan Francisco
$393
Southwest
Apr 18
SFO5:40 amSan Francisco
12h 00m
2 stops
GSP8:40 pmGreenville
Apr 25
GSP8:00 amGreenville
9h 25m
1 stop
SFO2:25 pmSan Francisco
$404

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 22, 2026.
Use the filters below to find and compare flights from San Francisco to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Wed 4/15

10:50 pm-9:46 am

1 stop7h 56m

Greenville

Tue 4/21

7:42 pm-1:17 am

1 stop8h 35m

$383

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Sun 8/23

8:30 pm-8:40 pm

1 stop21h 10m

Greenville

Mon 8/31

6:19 pm-12:02 pm

1 stop20h 43m

$386

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Wed 4/15

7:40 am-9:40 pm

2 stops11h 00m

Greenville

Tue 4/21

1:55 pm-9:25 pm

1 stop10h 30m

$388
Quickest round-trip

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Sat 5/23

9:52 pm-8:18 am

1 stop7h 26m

Greenville

Wed 5/27

7:54 pm-12:48 am

1 stop7h 54m

$391

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Wed 4/15

8:55 am-9:40 pm

2 stops9h 45m

Greenville

Tue 4/21

12:50 pm-10:05 pm

2 stops12h 15m

$393

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Sun 8/23

8:30 pm-8:40 pm

1 stop21h 10m

Greenville

Mon 8/31

8:28 pm-9:00 pm

2 stops27h 32m

$398

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Sat 4/18

5:00 am-3:54 pm

1 stop7h 54m

Greenville

Sat 4/25

5:41 pm-10:45 pm

1 stop8h 04m

$399

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Sat 4/18

5:40 am-8:40 pm

2 stops12h 00m

Greenville

Sat 4/25

8:00 am-2:25 pm

1 stop9h 25m

$404

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Thu 4/16

10:30 am-10:15 pm

2 stops8h 45m

Greenville

Mon 4/20

6:25 pm-12:20 am

2 stops8h 55m

$409

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Sat 5/23

9:52 pm-10:08 am

1 stop9h 16m

Greenville

Tue 5/26

6:41 pm-11:47 pm

1 stop8h 06m

$415

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from San Francisco to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Greenville?

The month of September is another great option to travel to Greenville, with average flight prices from San Francisco averaging around $410.

How far in advance should I book a flight to Greenville?

You are more likely to see cheaper flights to Greenville from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Greenville for around $469 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Greenville from San Francisco for as low as $338 on momondo.

How have San Francisco to Greenville flight prices changed over time?

As of March 2026, prices for San Francisco to Greenville flights are approximately 1% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Greenville (SFO to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Greenville

Fastest flight time

6h 38m

Direct flights

None
The fastest flight from San Francisco to Greenville takes 6h 38m
There are no direct flights from San Francisco to Greenville. There are no popular flight routes from San Francisco to Greenville.
Search flight deals

  • How far is San Francisco to Greenville by plane?

    The straight-line distance from San Francisco to Greenville is 2218.5 mi. Flights usually cover this in 6h 38m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from San Francisco Airport to Greenville Airport?

    Prices for flights from San Francisco Airport to Greenville Airport refresh daily.

  • How many operators does momondo search for flights from San Francisco Airport to Greenville Airport?

  • How old do you have to be to fly from San Francisco Airport to Greenville Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Francisco Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The required travel and health documents for your Greenville Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Greenville Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Francisco to Greenville?

Best airlines flying from San Francisco to Greenville

Compare and see reviews for airlines that fly from San Francisco to Greenville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $236Free CancellationRating
7.1
11,489 reviews
Search American Airlines flights
DeltaPriceFrom $305Free CancellationRating
7.9
8,314 reviews
Search Delta flights
SouthwestPriceFrom $313Free CancellationRating
8.0
4,324 reviews
Search Southwest flights
United AirlinesPriceFrom $424Free CancellationRating
7.4
9,455 reviews
Search United Airlines flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Greer
Seneca
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Greenville?

It is quick and easy to find San Francisco to Greenville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Greenville that suits you.

Can I find flights from San Francisco to Greenville with flexible booking policies on momondo?

All flight searches from San Francisco to Greenville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from San Francisco to Greenville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Greenville from San Francisco.

I’m not ready to book a flight from San Francisco to Greenville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from San Francisco to Greenville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Greenville and let you know when they change.

An easier way to manage your Greenville trip

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