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Cheap flights from San Francisco to Greenville from $145

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Greenville departing on 2/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from San Francisco to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
5:00 am - 3:08 pm
SFO
-
GSP
7h 08m1 stop
United Airlines Logo
2:55 pm - 10:57 pm
GSP
-
SFO
11h 02m1 stop
$340United Airlines
Thu, Jan 1 - Wed, Jan 7
American Airlines Logo
12:22 am - 10:11 am
SFO
-
GSP
6h 49m1 stop
American Airlines Logo
6:00 am - 12:40 pm
GSP
-
SFO
9h 40m2 stops
$345American Airlines
Wed, Dec 31 - Wed, Jan 7
United Airlines Logo
5:00 am - 3:35 pm
SFO
-
GSP
7h 35m1 stop
United Airlines Logo
4:50 pm - 10:59 pm
GSP
-
SFO
9h 09m1 stop
$373United Airlines
Wed, Jan 14 - Wed, Jan 21
American Airlines Logo
7:00 am - 5:09 pm
SFO
-
GSP
7h 09m1 stop
American Airlines Logo
6:00 am - 12:40 pm
GSP
-
SFO
9h 40m2 stops
$378American Airlines
Wed, Jan 14 - Wed, Jan 21
American Airlines Logo
9:00 am - 7:07 pm
SFO
-
GSP
7h 07m1 stop
American Airlines Logo
6:00 am - 1:50 pm
GSP
-
SFO
10h 50m1 stop
$393American Airlines
Mon, Jan 12 - Thu, Jan 15
American Airlines Logo
12:17 am - 1:17 pm
SFO
-
GSP
10h 00m2 stops
American Airlines Logo
5:26 pm - 10:34 pm
GSP
-
SFO
8h 08m1 stop
$398American Airlines
Sun, Jan 11 - Thu, Jan 15
Southwest Logo
2:15 pm - 10:05 am
SFO
-
GSP
16h 50m2 stops
Southwest Logo
10:05 am - 6:05 pm
GSP
-
SFO
11h 00m2 stops
$436Southwest
Thu, Jan 1 - Wed, Jan 7
Delta Logo
11:35 am - 10:00 pm
SFO
-
GSP
7h 25m1 stop
Delta Logo
3:42 pm - 10:49 pm
GSP
-
SFO
10h 07m1 stop
$447Delta
Fri, May 8 - Thu, May 14
Southwest Logo
8:50 am - 10:15 pm
SFO
-
GSP
10h 25m2 stops
Southwest Logo
12:35 pm - 7:35 pm
GSP
-
SFO
10h 00m1 stop
$452Southwest
Mon, May 11 - Fri, May 15
Southwest Logo
11:25 pm - 1:10 pm
SFO
-
GSP
10h 45m2 stops
Southwest Logo
6:25 am - 1:25 pm
GSP
-
SFO
10h 00m2 stops
$457Southwest
Mon, May 11 - Fri, May 15

United Airlines flights from San Francisco to Greenville

Our best United Airlines deals on San Francisco to Greenville flight tickets
United Airlines
Jan 1
SFO5:00 amSan Francisco
7h 08m
1 stop
GSP3:08 pmGreenville
Jan 7
GSP2:55 pmGreenville
11h 02m
1 stop
SFO10:57 pmSan Francisco
$340
Find similar
United Airlines
Jan 14
SFO5:00 amSan Francisco
7h 35m
1 stop
GSP3:35 pmGreenville
Jan 21
GSP4:50 pmGreenville
9h 09m
1 stop
SFO10:59 pmSan Francisco
$373
Find similar
United Airlines
Jan 20
SFO11:56 pmSan Francisco
7h 20m
1 stop
GSP10:16 amGreenville
Jan 24
GSP4:15 pmGreenville
8h 20m
1 stop
SFO9:35 pmSan Francisco
$442
Find similar

American Airlines flights from San Francisco to Greenville

Our best American Airlines deals on San Francisco to Greenville flight tickets
American Airlines
Dec 31
SFO12:22 amSan Francisco
6h 49m
1 stop
GSP10:11 amGreenville
Jan 7
GSP6:00 amGreenville
9h 40m
2 stops
SFO12:40 pmSan Francisco
$345
Find similar
American Airlines
Jan 14
SFO7:00 amSan Francisco
7h 09m
1 stop
GSP5:09 pmGreenville
Jan 21
GSP6:00 amGreenville
9h 40m
2 stops
SFO12:40 pmSan Francisco
$378
Find similar
American Airlines
Jan 12
SFO9:00 amSan Francisco
7h 07m
1 stop
GSP7:07 pmGreenville
Jan 15
GSP6:00 amGreenville
10h 50m
1 stop
SFO1:50 pmSan Francisco
$393
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from San Francisco to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Thu 1/1

5:00 am-3:08 pm

1 stop7h 08m

Greenville

Wed 1/7

2:55 pm-10:57 pm

1 stop11h 02m

$340

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Wed 12/31

12:22 am-10:11 am

1 stop6h 49m

Greenville

Wed 1/7

6:00 am-12:40 pm

2 stops9h 40m

$345

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Wed 1/14

5:00 am-3:35 pm

1 stop7h 35m

Greenville

Wed 1/21

4:50 pm-10:59 pm

1 stop9h 09m

$373

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Wed 1/14

7:00 am-5:09 pm

1 stop7h 09m

Greenville

Wed 1/21

6:00 am-12:40 pm

2 stops9h 40m

$378

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Mon 1/12

9:00 am-7:07 pm

1 stop7h 07m

Greenville

Thu 1/15

6:00 am-1:50 pm

1 stop10h 50m

$393

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Sun 1/11

12:17 am-1:17 pm

2 stops10h 00m

Greenville

Thu 1/15

5:26 pm-10:34 pm

1 stop8h 08m

$398

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Thu 1/1

2:15 pm-10:05 am

2 stops16h 50m

Greenville

Wed 1/7

10:05 am-6:05 pm

2 stops11h 00m

$436

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Fri 5/8

11:35 am-10:00 pm

1 stop7h 25m

Greenville

Thu 5/14

3:42 pm-10:49 pm

1 stop10h 07m

$447

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Mon 5/11

8:50 am-10:15 pm

2 stops10h 25m

Greenville

Fri 5/15

12:35 pm-7:35 pm

1 stop10h 00m

$452

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Mon 5/11

11:25 pm-1:10 pm

2 stops10h 45m

Greenville

Fri 5/15

6:25 am-1:25 pm

2 stops10h 00m

$457

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from San Francisco to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Greenville?

The month of September is another great option to travel to Greenville, with average flight prices from San Francisco averaging around $406.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Saturday is the cheapest day to fly to Greenville from San Francisco. The lowest ticket price found for a Saturday departure recently was $393. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $714. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the morning. Flights from San Francisco to Greenville during this time can be as low as $512. Flights to Greenville are more costly at noon, with an average ticket price of $545. Departure times at noon fall within the peak daily travel times, which is why tickets can be more expensive.

How far in advance should I book a flight to Greenville?

You are more likely to see cheaper flights to Greenville from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Greenville for around $487 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Greenville from San Francisco for as low as $341 on momondo.

How have San Francisco to Greenville flight prices changed over time?

As of December 2025, prices for San Francisco to Greenville flights are approximately 22% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Greenville (SFO to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Greenville

Fastest flight time

7h 07m

Direct flights

None
The fastest flight from San Francisco to Greenville takes 7h 07m
There are no direct flights from San Francisco to Greenville. There are no popular flight routes from San Francisco to Greenville.
Search flight deals

  • How far is San Francisco to Greenville by plane?

    The straight-line distance from San Francisco to Greenville is 2218.5 mi. Flights usually cover this in 7h 07m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from San Francisco Airport to Greenville Airport?

    Prices for flights from San Francisco Airport to Greenville Airport refresh daily.

  • How many operators does momondo search for flights from San Francisco Airport to Greenville Airport?

  • How old do you have to be to fly from San Francisco Airport to Greenville Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Francisco Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The required travel and health documents for your Greenville Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Greenville Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Francisco to Greenville?

Best airlines flying from San Francisco to Greenville

Compare and see reviews for airlines that fly from San Francisco to Greenville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $236Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights
DeltaPriceFrom $294Free CancellationRating
7.9
8,005 reviews
Search Delta flights
SouthwestPriceFrom $313Free CancellationRating
7.9
4,250 reviews
Search Southwest flights
United AirlinesPriceFrom $424Free CancellationRating
7.4
9,091 reviews
Search United Airlines flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Seneca
Greer
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Greenville?

It is quick and easy to find San Francisco to Greenville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Greenville that suits you.

Can I find flights from San Francisco to Greenville with flexible booking policies on momondo?

All flight searches from San Francisco to Greenville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from San Francisco to Greenville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Greenville from San Francisco.

I’m not ready to book a flight from San Francisco to Greenville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from San Francisco to Greenville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Greenville and let you know when they change.

An easier way to manage your Greenville trip

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