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Cheap flights from San Francisco to Greenville from $161

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Greenville departing on 11/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from San Francisco to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:30 am - 4:38 pmSFO  San Francisco-GSP Greenville
8h 08m1 stop Dallas/Fort Worth
American Airlines Logo
11:55 am - 6:08 pmGSP  Greenville-SFO San Francisco
9h 13m1 stop Charlotte Douglas
$311American Airlines
Sat, Sep 5 - Fri, Sep 11
Southwest Logo
10:30 pm - 10:35 amSFO  San Francisco-GSP Greenville
9h 05m1 stop Baltimore/Washington
Southwest Logo
1:05 pm - 9:55 pmGSP  Greenville-SFO San Francisco
11h 50m1 stop Nashville Intl
$316Southwest
Sat, Sep 5 - Fri, Sep 11
Southwest Logo
10:30 pm - 10:35 amSFO  San Francisco-GSP Greenville
9h 05m1 stop Baltimore/Washington
Southwest Logo
1:05 pm - 8:35 pmGSP  Greenville-SFO San Francisco
10h 30m2 stops Nashville Intl Las Vegas Harry Reid Intl
$316Southwest
Sat, Sep 5 - Fri, Sep 11
Southwest Logo
10:30 pm - 10:35 amSFO  San Francisco-GSP Greenville
9h 05m1 stop Baltimore/Washington
Southwest Logo
7:00 am - 12:25 pmGSP  Greenville-SFO San Francisco
8h 25m2 stops Nashville Intl Denver Intl
$316Southwest
Sat, Sep 5 - Fri, Sep 11
United Airlines Logo
10:45 am - 9:58 pmSFO  San Francisco-GSP Greenville
8h 13m1 stop Houston George Bush Intcntl
United Airlines Logo
6:10 pm - 12:18 amGSP  Greenville-SFO San Francisco
9h 08m1 stop Chicago O'Hare Intl
$334United Airlines
Wed, Sep 2 - Wed, Sep 9
Delta Logo
10:30 pm - 9:23 amSFO  San Francisco-GSP Greenville
7h 53m1 stop Atlanta Hartsfield-Jackson
Delta Logo
8:05 am - 2:42 pmGSP  Greenville-SFO San Francisco
9h 37m1 stop Atlanta Hartsfield-Jackson
$347Delta
Thu, Oct 15 - Mon, Oct 19
American Airlines Logo
5:00 am - 3:21 pmSFO  San Francisco-GSP Greenville
7h 21m1 stop Charlotte Douglas
American Airlines Logo
4:10 pm - 11:07 pmGSP  Greenville-SFO San Francisco
9h 57m1 stop Charlotte Douglas
$347American Airlines
Wed, Oct 7 - Wed, Oct 21
American Airlines Logo
11:13 am - 10:05 pmSFO  San Francisco-GSP Greenville
7h 52m1 stop Dallas/Fort Worth
American Airlines Logo
5:16 pm - 10:32 pmGSP  Greenville-SFO San Francisco
8h 16m1 stop Charlotte Douglas
$347American Airlines
Wed, Oct 21 - Wed, Nov 4
Delta Logo
9:55 pm - 10:10 amSFO  San Francisco-GSP Greenville
9h 15m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:00 pm - 11:57 pmGSP  Greenville-SFO San Francisco
9h 57m1 stop Atlanta Hartsfield-Jackson
$380Delta
Fri, Sep 25 - Wed, Sep 30
United Airlines Logo
11:30 pm - 9:51 amSFO  San Francisco-GSP Greenville
7h 21m1 stop Chicago O'Hare Intl
United Airlines Logo
4:29 pm - 11:09 pmGSP  Greenville-SFO San Francisco
9h 40m1 stop Denver Intl
$380United Airlines
Fri, Nov 6 - Mon, Nov 9

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American Airlines flights from San Francisco to Greenville

Our best American Airlines deals on San Francisco to Greenville flight tickets
American Airlines
Sep 5
SFO5:30 amSan Francisco
8h 08m
1 stop
GSP4:38 pmGreenville
Sep 11
GSP11:55 amGreenville
9h 13m
1 stop
SFO6:08 pmSan Francisco
$311
American Airlines
Oct 7
SFO5:00 amSan Francisco
7h 21m
1 stop
GSP3:21 pmGreenville
Oct 21
GSP4:10 pmGreenville
9h 57m
1 stop
SFO11:07 pmSan Francisco
$347
American Airlines
Sep 25
SFO11:03 pmSan Francisco
7h 34m
1 stop
GSP9:37 amGreenville
Sep 30
GSP5:24 pmGreenville
9h 04m
1 stop
SFO11:28 pmSan Francisco
$387

Delta flights from San Francisco to Greenville

Our best Delta deals on San Francisco to Greenville flight tickets
Delta
Sep 25
SFO9:55 pmSan Francisco
9h 15m
1 stop
GSP10:10 amGreenville
Sep 30
GSP5:00 pmGreenville
9h 57m
1 stop
SFO11:57 pmSan Francisco
$380
Delta
Oct 21
SFO10:59 pmSan Francisco
8h 19m
1 stop
GSP10:18 amGreenville
Nov 4
GSP8:05 amGreenville
12h 00m
2 stops
SFO5:05 pmSan Francisco
$442
Delta
Sep 2
SFO6:00 amSan Francisco
7h 15m
1 stop
GSP4:15 pmGreenville
Sep 4
GSP5:20 pmGreenville
9h 38m
1 stop
SFO11:58 pmSan Francisco
$448

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 6, 2026.
Use the filters below to find and compare flights from San Francisco to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San FranciscoGreenville

SFO San Francisco - GSP Greenville

SFOGSP

San Francisco

Sat 9/5

5:30 am-4:38 pm

1 stop8h 08m

Greenville

Fri 9/11

11:55 am-6:08 pm

1 stop9h 13m

$311

San FranciscoGreenville

SFO San Francisco - GSP Greenville

SFOGSP

San Francisco

Sat 9/5

10:30 pm-10:35 am

1 stop9h 05m

Greenville

Fri 9/11

1:05 pm-9:55 pm

1 stop11h 50m

$316

San FranciscoGreenville

SFO San Francisco - GSP Greenville

SFOGSP

San Francisco

Sat 9/5

10:30 pm-10:35 am

1 stop9h 05m

Greenville

Fri 9/11

1:05 pm-8:35 pm

2 stops10h 30m

$316

San FranciscoGreenville

SFO San Francisco - GSP Greenville

SFOGSP

San Francisco

Sat 9/5

10:30 pm-10:35 am

1 stop9h 05m

Greenville

Fri 9/11

7:00 am-12:25 pm

2 stops8h 25m

$316

San FranciscoGreenville

SFO San Francisco - GSP Greenville

SFOGSP

San Francisco

Wed 9/2

10:45 am-9:58 pm

1 stop8h 13m

Greenville

Wed 9/9

6:10 pm-12:18 am

1 stop9h 08m

$334

San FranciscoGreenville

SFO San Francisco - GSP Greenville

SFOGSP

San Francisco

Thu 10/15

10:30 pm-9:23 am

1 stop7h 53m

Greenville

Mon 10/19

8:05 am-2:42 pm

1 stop9h 37m

$347

San FranciscoGreenville

SFO San Francisco - GSP Greenville

SFOGSP

San Francisco

Wed 10/7

5:00 am-3:21 pm

1 stop7h 21m

Greenville

Wed 10/21

4:10 pm-11:07 pm

1 stop9h 57m

$347
Quickest round-trip

San FranciscoGreenville

SFO San Francisco - GSP Greenville

SFOGSP

San Francisco

Wed 10/21

11:13 am-10:05 pm

1 stop7h 52m

Greenville

Wed 11/4

5:16 pm-10:32 pm

1 stop8h 16m

$347

San FranciscoGreenville

SFO San Francisco - GSP Greenville

SFOGSP

San Francisco

Fri 9/25

9:55 pm-10:10 am

1 stop9h 15m

Greenville

Wed 9/30

5:00 pm-11:57 pm

1 stop9h 57m

$380

San FranciscoGreenville

SFO San Francisco - GSP Greenville

SFOGSP

San Francisco

Fri 11/6

11:30 pm-9:51 am

1 stop7h 21m

Greenville

Mon 11/9

4:29 pm-11:09 pm

1 stop9h 40m

$380

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from San Francisco to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Francisco and Greenville?

Prices are currently low for flights on this route.

Typical prices usually range from $406 to $600.
The lowest price recently found on this route was $311.

What is the cheapest month to fly to Greenville?

The month of September is another great option to travel to Greenville, with average flight prices from San Francisco averaging around $423.

How have San Francisco to Greenville flight prices changed over time?

As of August 2026, prices for San Francisco to Greenville flights are approximately 5% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Greenville (SFO to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Greenville

Fastest flight time

7h 25m

Direct flights

None
The fastest flight from San Francisco to Greenville takes 7h 25m
There are no direct flights from San Francisco to Greenville. There are no popular flight routes from San Francisco to Greenville.
Search flight deals

Frequently asked questions about flying from San Francisco to Greenville

  • How far is San Francisco to Greenville by plane?

    The straight-line distance from San Francisco to Greenville is 2218.0 mi. Flights usually cover this in 7h 25m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from San Francisco Airport to Greenville Airport?

    Prices for flights from San Francisco Airport to Greenville Airport refresh daily.

  • How many operators does momondo search for flights from San Francisco Airport to Greenville Airport?

  • How old do you have to be to fly from San Francisco Airport to Greenville Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Francisco Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The required travel and health documents for your Greenville Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Greenville Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Francisco to Greenville?

Best airlines flying from San Francisco to Greenville

Compare and see reviews for airlines that fly from San Francisco to Greenville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $274Free CancellationRating
7.1
11,865 reviews
Search American Airlines flights
DeltaPriceFrom $353Free CancellationRating
7.8
8,491 reviews
Search Delta flights
United AirlinesPriceFrom $424Free CancellationRating
7.4
10,072 reviews
Search United Airlines flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Greer
Seneca
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Greenville?

It is quick and easy to find San Francisco to Greenville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Greenville that suits you.

Can I find flights from San Francisco to Greenville with flexible booking policies on momondo?

All flight searches from San Francisco to Greenville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from San Francisco to Greenville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Greenville from San Francisco.

I’m not ready to book a flight from San Francisco to Greenville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from San Francisco to Greenville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Greenville and let you know when they change.

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