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Cheap flights from San Francisco to Greenville from $189

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Greenville departing on 5/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from San Francisco to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
5:00 am - 3:19 pm
SFO
-
GSP
7h 19m
1 stop
United Airlines Logo
7:40 pm - 1:15 am
GSP
-
SFO
8h 35m
1 stop
$383United Airlines
Tue, Jun 2 - Tue, Jun 9
Southwest Logo
11:25 pm - 1:10 pm
SFO
-
GSP
10h 45m
2 stops
Southwest Logo
7:00 am - 1:40 pm
GSP
-
SFO
9h 40m
2 stops
$393Southwest
Tue, Jun 2 - Tue, Jun 9
Southwest Logo
10:40 pm - 12:10 pm
SFO
-
GSP
10h 30m
1 stop
Southwest Logo
12:50 pm - 7:55 pm
GSP
-
SFO
10h 05m
2 stops
$394Southwest
Tue, Jun 2 - Tue, Jun 9
American Airlines Logo
12:00 pm - 11:59 pm
SFO
-
GSP
8h 59m
1 stop
American Airlines Logo
7:55 pm - 12:48 am
GSP
-
SFO
7h 53m
1 stop
$395American Airlines
Wed, Jun 3 - Wed, Jun 10
American Airlines Logo
6:36 am - 7:33 pm
SFO
-
GSP
9h 57m
1 stop
American Airlines Logo
6:47 am - 1:13 pm
GSP
-
SFO
9h 26m
1 stop
$397American Airlines
Thu, Aug 20 - Tue, Aug 25
American Airlines Logo
5:30 am - 4:35 pm
SFO
-
GSP
8h 05m
1 stop
American Airlines Logo
6:47 am - 1:12 pm
GSP
-
SFO
9h 25m
2 stops
$400American Airlines
Tue, Aug 18 - Tue, Aug 25
Southwest Logo
11:40 pm - 12:30 pm
SFO
-
GSP
9h 50m
2 stops
Southwest Logo
11:00 am - 4:25 pm
GSP
-
SFO
8h 25m
1 stop
$402Southwest
Thu, Aug 20 - Tue, Aug 25
Southwest Logo
7:40 am - 8:55 pm
SFO
-
GSP
10h 15m
2 stops
Southwest Logo
7:00 am - 1:15 pm
GSP
-
SFO
9h 15m
2 stops
$405Southwest
Tue, Aug 18 - Tue, Aug 25
American Airlines Logo
12:01 pm - 11:59 pm
SFO
-
GSP
8h 58m
1 stop
American Airlines Logo
5:25 pm - 12:48 am
GSP
-
SFO
10h 23m
1 stop
$406American Airlines
Tue, Jun 23 - Tue, Jun 30
Southwest Logo
11:40 pm - 12:30 pm
SFO
-
GSP
9h 50m
2 stops
Southwest Logo
7:00 am - 1:50 pm
GSP
-
SFO
9h 50m
2 stops
$407Southwest
Thu, Aug 20 - Tue, Aug 25

American Airlines flights from San Francisco to Greenville

Our best American Airlines deals on San Francisco to Greenville flight tickets
American Airlines
Jun 3
SFO12:00 pmSan Francisco
8h 59m
1 stop
GSP11:59 pmGreenville
Jun 10
GSP7:55 pmGreenville
7h 53m
1 stop
SFO12:48 amSan Francisco
$395
American Airlines
Aug 20
SFO6:36 amSan Francisco
9h 57m
1 stop
GSP7:33 pmGreenville
Aug 25
GSP6:47 amGreenville
9h 26m
1 stop
SFO1:13 pmSan Francisco
$397
American Airlines
Aug 18
SFO5:30 amSan Francisco
8h 05m
1 stop
GSP4:35 pmGreenville
Aug 25
GSP6:47 amGreenville
9h 25m
2 stops
SFO1:12 pmSan Francisco
$400

United Airlines flights from San Francisco to Greenville

Our best United Airlines deals on San Francisco to Greenville flight tickets
United Airlines
Jun 2
SFO5:00 amSan Francisco
7h 19m
1 stop
GSP3:19 pmGreenville
Jun 9
GSP7:40 pmGreenville
8h 35m
1 stop
SFO1:15 amSan Francisco
$383
United Airlines
May 22
SFO10:35 pmSan Francisco
9h 02m
1 stop
GSP10:37 amGreenville
May 26
GSP7:40 pmGreenville
8h 35m
1 stop
SFO1:15 amSan Francisco
$491
United Airlines
Sep 15
SFO5:00 amSan Francisco
7h 10m
1 stop
GSP3:10 pmGreenville
Sep 16
GSP7:00 amGreenville
10h 39m
1 stop
SFO2:39 pmSan Francisco
$505

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 9, 2026.
Use the filters below to find and compare flights from San Francisco to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Tue 6/2

5:00 am-3:19 pm

1 stop7h 19m

Greenville

Tue 6/9

7:40 pm-1:15 am

1 stop8h 35m

$383

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Tue 6/2

11:25 pm-1:10 pm

2 stops10h 45m

Greenville

Tue 6/9

7:00 am-1:40 pm

2 stops9h 40m

$393

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Tue 6/2

10:40 pm-12:10 pm

1 stop10h 30m

Greenville

Tue 6/9

12:50 pm-7:55 pm

2 stops10h 05m

$394

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Wed 6/3

12:00 pm-11:59 pm

1 stop8h 59m

Greenville

Wed 6/10

7:55 pm-12:48 am

1 stop7h 53m

$395

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Thu 8/20

6:36 am-7:33 pm

1 stop9h 57m

Greenville

Tue 8/25

6:47 am-1:13 pm

1 stop9h 26m

$397

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Tue 8/18

5:30 am-4:35 pm

1 stop8h 05m

Greenville

Tue 8/25

6:47 am-1:12 pm

2 stops9h 25m

$400

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Thu 8/20

11:40 pm-12:30 pm

2 stops9h 50m

Greenville

Tue 8/25

11:00 am-4:25 pm

1 stop8h 25m

$402

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Tue 8/18

7:40 am-8:55 pm

2 stops10h 15m

Greenville

Tue 8/25

7:00 am-1:15 pm

2 stops9h 15m

$405

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Tue 6/23

12:01 pm-11:59 pm

1 stop8h 58m

Greenville

Tue 6/30

5:25 pm-12:48 am

1 stop10h 23m

$406

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Thu 8/20

11:40 pm-12:30 pm

2 stops9h 50m

Greenville

Tue 8/25

7:00 am-1:50 pm

2 stops9h 50m

$407

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from San Francisco to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Francisco and Greenville?

What is the cheapest month to fly to Greenville?

The month of September is another great option to travel to Greenville, with average flight prices from San Francisco averaging around $410.

How far in advance should I book a flight from San Francisco to Greenville?

You are more likely to see cheaper flights to Greenville from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Greenville for around $476 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Greenville from San Francisco for as low as $342 on momondo.

How have San Francisco to Greenville flight prices changed over time?

As of May 2026, prices for San Francisco to Greenville flights are approximately 16% cheaper when compared to flights at the same time last year.

When to book flights from San Francisco to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Greenville (SFO to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Greenville

Fastest flight time

7h 19m

Direct flights

None
The fastest flight from San Francisco to Greenville takes 7h 19m
There are no direct flights from San Francisco to Greenville. There are no popular flight routes from San Francisco to Greenville.
Search flight deals

Frequently asked questions about flying from San Francisco to Greenville

  • How far is San Francisco to Greenville by plane?

    The straight-line distance from San Francisco to Greenville is 2218.0 mi. Flights usually cover this in 7h 19m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from San Francisco Airport to Greenville Airport?

    Prices for flights from San Francisco Airport to Greenville Airport refresh daily.

  • How many operators does momondo search for flights from San Francisco Airport to Greenville Airport?

  • How old do you have to be to fly from San Francisco Airport to Greenville Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Francisco Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The required travel and health documents for your Greenville Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Greenville Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Francisco to Greenville?

Best airlines flying from San Francisco to Greenville

Compare and see reviews for airlines that fly from San Francisco to Greenville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $236Free CancellationRating
7.1
11,669 reviews
Search American Airlines flights
DeltaPriceFrom $305Free CancellationRating
7.9
8,457 reviews
Search Delta flights
SouthwestPriceFrom $313Free CancellationRating
8.0
4,302 reviews
Search Southwest flights
United AirlinesPriceFrom $424Free CancellationRating
7.4
9,692 reviews
Search United Airlines flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Greer
Seneca
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Greenville?

It is quick and easy to find San Francisco to Greenville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Greenville that suits you.

Can I find flights from San Francisco to Greenville with flexible booking policies on momondo?

All flight searches from San Francisco to Greenville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from San Francisco to Greenville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Greenville from San Francisco.

I’m not ready to book a flight from San Francisco to Greenville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from San Francisco to Greenville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Greenville and let you know when they change.

An easier way to manage your Greenville trip

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