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Cheap flights from San Francisco to Florence from $208

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Florence departing on 8/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Francisco to Florence

Cheap round-trip flights

American Airlines Logo
12:51 pm - 11:02 pmSFO-FLO
7h 11m1 stop
American Airlines Logo
6:14 am - 11:30 amFLO-SFO
8h 16m1 stop
$357American Airlines
Find Deal
Wed, Aug 27 - Wed, Sep 3
American Airlines Logo
8:00 am - 11:02 pmSFO-FLO
12h 02m2 stops
American Airlines Logo
6:14 am - 11:30 amFLO-SFO
8h 16m1 stop
$362American Airlines
Find Deal
Wed, Aug 27 - Wed, Sep 3
American Airlines Logo
8:00 am - 11:02 pmSFO-FLO
12h 02m2 stops
American Airlines Logo
6:14 am - 1:08 pmFLO-SFO
9h 54m2 stops
$367American Airlines
Find Deal
Wed, Aug 27 - Wed, Sep 3
American Airlines Logo
12:38 pm - 11:16 pmSFO-FLO
7h 38m1 stop
American Airlines Logo
6:14 am - 11:30 amFLO-SFO
8h 16m1 stop
$389American Airlines
Find Deal
Sat, Sep 27 - Tue, Sep 30
American Airlines Logo
8:00 am - 11:16 pmSFO-FLO
12h 16m2 stops
American Airlines Logo
6:14 am - 11:30 amFLO-SFO
8h 16m1 stop
$394American Airlines
Find Deal
Sat, Sep 27 - Tue, Sep 30
American Airlines Logo
7:00 am - 11:16 pmSFO-FLO
13h 16m2 stops
American Airlines Logo
6:14 am - 4:03 pmFLO-SFO
12h 49m2 stops
$399American Airlines
Find Deal
Sat, Sep 27 - Tue, Sep 30
American Airlines Logo
12:51 pm - 11:02 pmSFO-FLO
7h 11m1 stop
American Airlines Logo
6:20 am - 11:50 amFLO-SFO
8h 30m1 stop
$497American Airlines
Find Deal
Fri, Aug 15 - Tue, Aug 19
American Airlines Logo
12:45 am - 3:04 pmSFO-FLO
11h 19m2 stops
American Airlines Logo
6:20 am - 11:50 amFLO-SFO
8h 30m1 stop
$502American Airlines
Find Deal
Thu, Aug 14 - Tue, Aug 19
American Airlines Logo
12:45 am - 3:04 pmSFO-FLO
11h 19m2 stops
American Airlines Logo
6:20 am - 2:27 pmFLO-SFO
11h 07m2 stops
$507American Airlines
Find Deal
Thu, Aug 14 - Tue, Aug 19
American Airlines Logo
5:15 am - 3:04 pmSFO-FLO
6h 49m1 stop
American Airlines Logo
3:30 pm - 7:46 pmFLO-SFO
7h 16m1 stop
$517American Airlines
Find Deal
Mon, Aug 11 - Fri, Aug 15

American Airlines flights from San Francisco to Florence, South Carolina

Our best American Airlines deals on San Francisco to Florence, South Carolina flight tickets
American Airlines
Aug 27
SFO12:51 pmSan Francisco
7h 11m
1 stop
FLO11:02 pmFlorence
Sep 3
FLO6:14 amFlorence
8h 16m
1 stop
SFO11:30 amSan Francisco
$357
Find similar
American Airlines
Aug 27
SFO8:00 amSan Francisco
12h 02m
2 stops
FLO11:02 pmFlorence
Sep 3
FLO6:14 amFlorence
8h 16m
1 stop
SFO11:30 amSan Francisco
$362
Find similar
American Airlines
Aug 27
SFO8:00 amSan Francisco
12h 02m
2 stops
FLO11:02 pmFlorence
Sep 3
FLO6:14 amFlorence
9h 54m
2 stops
SFO1:08 pmSan Francisco
$367
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 29, 2025.
Use the filters below to find and compare flights from San Francisco to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Wed 8/27

12:51 pm-11:02 pm

1 stop7h 11m

Florence

Wed 9/3

6:14 am-11:30 am

1 stop8h 16m

$357

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Wed 8/27

8:00 am-11:02 pm

2 stops12h 02m

Florence

Wed 9/3

6:14 am-11:30 am

1 stop8h 16m

$362

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Wed 8/27

8:00 am-11:02 pm

2 stops12h 02m

Florence

Wed 9/3

6:14 am-1:08 pm

2 stops9h 54m

$367

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Sat 9/27

12:38 pm-11:16 pm

1 stop7h 38m

Florence

Tue 9/30

6:14 am-11:30 am

1 stop8h 16m

$389

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Sat 9/27

8:00 am-11:16 pm

2 stops12h 16m

Florence

Tue 9/30

6:14 am-11:30 am

1 stop8h 16m

$394

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Sat 9/27

7:00 am-11:16 pm

2 stops13h 16m

Florence

Tue 9/30

6:14 am-4:03 pm

2 stops12h 49m

$399

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Fri 8/15

12:51 pm-11:02 pm

1 stop7h 11m

Florence

Tue 8/19

6:20 am-11:50 am

1 stop8h 30m

$497

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Thu 8/14

12:45 am-3:04 pm

2 stops11h 19m

Florence

Tue 8/19

6:20 am-11:50 am

1 stop8h 30m

$502

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Thu 8/14

12:45 am-3:04 pm

2 stops11h 19m

Florence

Tue 8/19

6:20 am-2:27 pm

2 stops11h 07m

$507

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Mon 8/11

5:15 am-3:04 pm

1 stop6h 49m

Florence

Fri 8/15

3:30 pm-7:46 pm

1 stop7h 16m

$517

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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2

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How to get the cheapest flight ticket from San Francisco to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Florence, South Carolina?

On average, the least expensive day to fly to Florence, South Carolina from San Francisco is on a Thursday. momondo users have found tickets for Thursday departures for as low as $497. However, this price may fluctuate depending on the airline, the season, and holidays. On the other hand, Saturday is the most expensive day to depart from San Francisco because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $559.

What is the cheapest time of day to depart on your flight to Florence, South Carolina?

According to our data, the cheapest time of day to fly to Florence, South Carolina is in the morning. momondo users have found flights departing from San Francisco to Florence, South Carolina in the morning for as low as $517. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. In the evening is when there is more demand to fly to Florence, South Carolina, so prices are often more expensive at around $609 per ticket.

When to book flights from San Francisco to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Florence, South Carolina (SFO to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Florence, South Carolina

Best Price Found

$208

Fastest flight time

6h 49m

Direct flights

None

Airports in Florence, South Carolina

1 airport
The best one-way flight to Florence, South Carolina from San Francisco in the past 72 hours is $208. The best round-trip flight deal from San Francisco to Florence, South Carolina found on momondo in the last 72 hours is $357.
The fastest flight from San Francisco to Florence, South Carolina takes 6h 49m
There are no direct flights from San Francisco to Florence, South Carolina. Popular non-direct route for this connection is San Francisco Airport - Florence Airport.
There is 1 airport near Florence, South Carolina: Florence (FLO)
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  • How far is San Francisco to Florence by plane?

    Florence is 2374.9 mi away from San Francisco. 6h 49m is a normal flight duration for this route.

  • When did momondo last update prices for flights from San Francisco Airport to Florence Airport?

    Prices for flights from San Francisco Airport to Florence Airport are updated daily.

  • How many operators does momondo search for flights from San Francisco Airport to Florence Airport?

  • How old do you have to be to fly from San Francisco Airport to Florence Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from San Francisco to Florence, South Carolina?

Best airlines flying from San Francisco to Florence, South Carolina

Compare and see reviews for airlines that fly from San Francisco to Florence, South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $400Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Lake City
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Florence?

Finding the right flight to Florence from San Francisco is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Florence quick and easy, saving you time and money.

Can I find flights from San Francisco to Florence with flexible booking policies on momondo?

All flight searches from San Francisco to Florence on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from San Francisco to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from San Francisco to Florence.

I’m not ready to book a flight from San Francisco to Florence right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Francisco to Florence flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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