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Cheap flights from San Francisco to Florence from $583

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Florence departing on 12/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
12:25 am - 10:51 amSFO-FLO
7h 26m1 stop
American Airlines Logo
6:15 am - 1:37 pmFLO-SFO
10h 22m1 stop
$583American Airlines
Find Deal
Fri, Dec 12 - Tue, Dec 16
American Airlines Logo
12:25 am - 10:51 amSFO-FLO
7h 26m1 stop
American Airlines Logo
11:15 am - 7:14 pmFLO-SFO
10h 59m2 stops
$588American Airlines
Find Deal
Fri, Dec 12 - Tue, Dec 16
American Airlines Logo
7:00 am - 12:15 amSFO-FLO
14h 15m2 stops
American Airlines Logo
11:15 am - 8:56 pmFLO-SFO
12h 41m2 stops
$593American Airlines
Find Deal
Sat, Dec 13 - Tue, Dec 16
American Airlines Logo
7:00 am - 6:05 pmSFO-FLO
8h 05m1 stop
American Airlines Logo
1:07 pm - 8:51 pmFLO-SFO
10h 44m1 stop
$651American Airlines
Find Deal
Thu, Dec 18 - Sun, Dec 28
American Airlines Logo
7:09 am - 12:15 amSFO-FLO
14h 06m2 stops
American Airlines Logo
1:07 pm - 8:51 pmFLO-SFO
10h 44m1 stop
$656American Airlines
Find Deal
Thu, Dec 18 - Sun, Dec 28
American Airlines Logo
11:50 pm - 9:50 amSFO-FLO
7h 00m1 stop
American Airlines Logo
12:51 pm - 5:52 pmFLO-SFO
8h 01m1 stop
$708American Airlines
Find Deal
Sun, Dec 14 - Sat, Dec 20
American Airlines Logo
11:59 pm - 9:50 amSFO-FLO
6h 51m1 stop
American Airlines Logo
5:15 am - 10:58 pmFLO-SFO
20h 43m2 stops
$743American Airlines
Find Deal
Tue, Dec 16 - Fri, Dec 26
American Airlines Logo
9:15 am - 10:53 pmSFO-FLO
10h 38m2 stops
American Airlines Logo
5:15 am - 10:58 pmFLO-SFO
20h 43m2 stops
$748American Airlines
Find Deal
Tue, Dec 16 - Fri, Dec 26
American Airlines Logo
12:22 am - 12:26 pmSFO-FLO
9h 04m1 stop
American Airlines Logo
1:07 pm - 8:51 pmFLO-SFO
10h 44m1 stop
$754American Airlines
Find Deal
Wed, Dec 17 - Sun, Dec 28
American Airlines Logo
12:25 am - 10:51 amSFO-FLO
7h 26m1 stop
American Airlines Logo
5:15 am - 3:06 pmFLO-SFO
12h 51m2 stops
$756American Airlines
Find Deal
Sat, Dec 13 - Sat, Dec 20

American Airlines flights from San Francisco to Florence, South Carolina

Our best American Airlines deals on San Francisco to Florence, South Carolina flight tickets
American Airlines
Dec 12
SFO12:25 amSan Francisco
7h 26m
1 stop
FLO10:51 amFlorence
Dec 16
FLO6:15 amFlorence
10h 22m
1 stop
SFO1:37 pmSan Francisco
$583
Find similar
American Airlines
Dec 12
SFO12:25 amSan Francisco
7h 26m
1 stop
FLO10:51 amFlorence
Dec 16
FLO11:15 amFlorence
10h 59m
2 stops
SFO7:14 pmSan Francisco
$588
Find similar
American Airlines
Dec 13
SFO7:00 amSan Francisco
14h 15m
2 stops
FLO12:15 amFlorence
Dec 16
FLO11:15 amFlorence
11h 09m
2 stops
SFO7:24 pmSan Francisco
$593
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 2, 2025.
Use the filters below to find and compare flights from San Francisco to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Fri 12/12

12:25 am-10:51 am

1 stop7h 26m

Florence

Tue 12/16

6:15 am-1:37 pm

1 stop10h 22m

$583

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Fri 12/12

12:25 am-10:51 am

1 stop7h 26m

Florence

Tue 12/16

11:15 am-7:14 pm

2 stops10h 59m

$588

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Sat 12/13

7:00 am-12:15 am

2 stops14h 15m

Florence

Tue 12/16

11:15 am-8:56 pm

2 stops12h 41m

$593

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Thu 12/18

7:00 am-6:05 pm

1 stop8h 05m

Florence

Sun 12/28

1:07 pm-8:51 pm

1 stop10h 44m

$651

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Thu 12/18

7:09 am-12:15 am

2 stops14h 06m

Florence

Sun 12/28

1:07 pm-8:51 pm

1 stop10h 44m

$656

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Sun 12/14

11:50 pm-9:50 am

1 stop7h 00m

Florence

Sat 12/20

12:51 pm-5:52 pm

1 stop8h 01m

$708

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Tue 12/16

11:59 pm-9:50 am

1 stop6h 51m

Florence

Fri 12/26

5:15 am-10:58 pm

2 stops20h 43m

$743

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Tue 12/16

9:15 am-10:53 pm

2 stops10h 38m

Florence

Fri 12/26

5:15 am-10:58 pm

2 stops20h 43m

$748

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Wed 12/17

12:22 am-12:26 pm

1 stop9h 04m

Florence

Sun 12/28

1:07 pm-8:51 pm

1 stop10h 44m

$754

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Sat 12/13

12:25 am-10:51 am

1 stop7h 26m

Florence

Sat 12/20

5:15 am-3:06 pm

2 stops12h 51m

$756

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from San Francisco to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Florence, South Carolina?

On average, the least expensive day to fly to Florence, South Carolina from San Francisco is on a Thursday. momondo users have found tickets for Thursday departures for as low as $497. However, this price may fluctuate depending on the airline, the season, and holidays. On the other hand, Saturday is the most expensive day to depart from San Francisco because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $559.

What is the cheapest time of day to depart on your flight to Florence, South Carolina?

According to our data, the cheapest time of day to fly to Florence, South Carolina is in the morning. momondo users have found flights departing from San Francisco to Florence, South Carolina in the morning for as low as $517. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. In the evening is when there is more demand to fly to Florence, South Carolina, so prices are often more expensive at around $609 per ticket.

Can stopping save me money on San Francisco to Florence, South Carolina flights?

You could potentially save up to 6% on your flight if you consider stops on a San Francisco to Florence, South Carolina flight.

When to book flights from San Francisco to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Florence, South Carolina (SFO to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Florence, South Carolina

Fastest flight time

10h 09m

Direct flights

None
The fastest flight from San Francisco to Florence, South Carolina takes 10h 09m
There are no direct flights from San Francisco to Florence, South Carolina. There are no popular flight routes from San Francisco to Florence, South Carolina.
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  • How far is San Francisco to Florence by plane?

    Florence is 2374.9 mi away from San Francisco. 6h 51m is a normal flight duration for this route.

  • When did momondo last update prices for flights from San Francisco Airport to Florence Airport?

    Prices for flights from San Francisco Airport to Florence Airport are updated daily.

  • How many operators does momondo search for flights from San Francisco Airport to Florence Airport?

  • How old do you have to be to fly from San Francisco Airport to Florence Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from San Francisco to Florence, South Carolina?

Best airlines flying from San Francisco to Florence, South Carolina

Compare and see reviews for airlines that fly from San Francisco to Florence, South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $400Free CancellationRating
7.2
11,041 reviews
Search American Airlines flights

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Florence?

Finding the right flight to Florence from San Francisco is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Florence quick and easy, saving you time and money.

Can I find flights from San Francisco to Florence with flexible booking policies on momondo?

All flight searches from San Francisco to Florence on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from San Francisco to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from San Francisco to Florence.

I’m not ready to book a flight from San Francisco to Florence right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Francisco to Florence flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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