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Cheap flights from San Francisco to Florence from $279

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Florence departing on 2/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Francisco to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:00 am - 10:42 pm
SFO
-
FLO
12h 42m
2 stops
American Airlines Logo
4:16 pm - 9:28 pm
FLO
-
SFO
8h 12m
1 stop
$472American Airlines
Tue, Apr 14 - Sun, Apr 19
American Airlines Logo
6:00 am - 10:42 pm
SFO
-
FLO
13h 42m
2 stops
American Airlines Logo
4:16 pm - 12:17 am
FLO
-
SFO
11h 01m
2 stops
$554American Airlines
Tue, Apr 14 - Sun, Apr 19
American Airlines Logo
7:00 am - 5:09 pm
SFO
-
FLO
7h 09m
1 stop
American Airlines Logo
5:36 pm - 10:25 pm
FLO
-
SFO
7h 49m
1 stop
$557American Airlines
Sat, Jan 31 - Wed, Feb 4
American Airlines Logo
6:00 am - 11:11 pm
SFO
-
FLO
14h 11m
2 stops
American Airlines Logo
5:36 pm - 10:25 pm
FLO
-
SFO
7h 49m
1 stop
$562American Airlines
Sat, Jan 31 - Wed, Feb 4
American Airlines Logo
7:00 am - 11:11 pm
SFO
-
FLO
13h 11m
2 stops
American Airlines Logo
6:15 am - 3:05 pm
FLO
-
SFO
11h 50m
2 stops
$568American Airlines
Sat, Jan 31 - Wed, Feb 4
American Airlines Logo
11:30 pm - 11:53 pm
SFO
-
FLO
21h 23m
1 stop
American Airlines Logo
5:24 am - 8:11 pm
FLO
-
SFO
17h 47m
1 stop
$793American Airlines
Tue, Apr 14 - Sun, Apr 19

American Airlines flights from San Francisco to Florence, South Carolina

Our best American Airlines deals on San Francisco to Florence, South Carolina flight tickets
American Airlines
Apr 20
SFO12:59 amSan Francisco
11h 33m
2 stops
FLO3:32 pmFlorence
May 2
FLO4:16 pmFlorence
8h 12m
1 stop
SFO9:28 pmSan Francisco
$412
American Airlines
Apr 20
SFO12:59 amSan Francisco
11h 33m
2 stops
FLO3:32 pmFlorence
May 2
FLO5:24 amFlorence
13h 17m
2 stops
SFO3:41 pmSan Francisco
$418
American Airlines
Apr 14
SFO7:00 amSan Francisco
12h 42m
2 stops
FLO10:42 pmFlorence
Apr 19
FLO4:16 pmFlorence
8h 12m
1 stop
SFO9:28 pmSan Francisco
$472

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 18, 2026.
Use the filters below to find and compare flights from San Francisco to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Tue 4/14

7:00 am-10:42 pm

2 stops12h 42m

Florence

Sun 4/19

4:16 pm-9:28 pm

1 stop8h 12m

$472

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Tue 4/14

6:00 am-10:42 pm

2 stops13h 42m

Florence

Sun 4/19

4:16 pm-12:17 am

2 stops11h 01m

$554

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Sat 1/31

7:00 am-5:09 pm

1 stop7h 09m

Florence

Wed 2/4

5:36 pm-10:25 pm

1 stop7h 49m

$557

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Sat 1/31

6:00 am-11:11 pm

2 stops14h 11m

Florence

Wed 2/4

5:36 pm-10:25 pm

1 stop7h 49m

$562

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Sat 1/31

7:00 am-11:11 pm

2 stops13h 11m

Florence

Wed 2/4

6:15 am-3:05 pm

2 stops11h 50m

$568

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Tue 4/14

11:30 pm-11:53 pm

1 stop21h 23m

Florence

Sun 4/19

5:24 am-8:11 pm

1 stop17h 47m

$793

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Thu 2/5

7:00 am-5:09 pm

1 stop7h 09m

$279

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Thu 2/5

6:00 am-10:43 pm

2 stops13h 43m

$284

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from San Francisco to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on San Francisco to Florence, South Carolina flights?

You could potentially save up to 6% on your flight if you consider stops on a San Francisco to Florence, South Carolina flight.

When to book flights from San Francisco to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Florence, South Carolina (SFO to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Florence, South Carolina

Fastest flight time

7h 09m

Direct flights

None
The fastest flight from San Francisco to Florence, South Carolina takes 7h 09m
There are no direct flights from San Francisco to Florence, South Carolina. There are no popular flight routes from San Francisco to Florence, South Carolina.
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  • How far is San Francisco to Florence by plane?

    Florence is 2374.9 mi away from San Francisco. 7h 09m is a normal flight duration for this route.

  • When did momondo last update prices for flights from San Francisco Airport to Florence Airport?

    Prices for flights from San Francisco Airport to Florence Airport are updated daily.

  • How old do you have to be to fly from San Francisco Airport to Florence Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Lake City
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Florence?

Finding the right flight to Florence from San Francisco is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Florence quick and easy, saving you time and money.

Can I find flights from San Francisco to Florence with flexible booking policies on momondo?

All flight searches from San Francisco to Florence on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from San Francisco to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from San Francisco to Florence.

I’m not ready to book a flight from San Francisco to Florence right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Francisco to Florence flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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