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Cheap flights from San Diego to Greenville from $141

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to Greenville departing on 12/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from San Diego to Greenville

Cheap round-trip flights

American Airlines Logo
11:46 am - 9:11 pmSAN-GSP
6h 25m1 stop
American Airlines Logo
6:01 am - 11:18 amGSP-SAN
8h 17m1 stop
$370American Airlines
Find Deal
Sat, Oct 25 - Mon, Nov 3
American Airlines Logo
6:15 am - 9:54 pmSAN-GSP
12h 39m1 stop
American Airlines Logo
11:26 am - 7:23 pmGSP-SAN
10h 57m1 stop
$390American Airlines
Find Deal
Tue, Sep 30 - Tue, Oct 7
Southwest Logo
9:45 pm - 9:45 amSAN-GSP
9h 00m1 stop
Southwest Logo
3:05 pm - 6:55 pmGSP-SAN
6h 50m1 stop
$392Southwest
Find Deal
Sun, Nov 9 - Wed, Nov 12
Southwest Logo
6:35 am - 3:40 pmSAN-GSP
6h 05m1 stop
Southwest Logo
3:05 pm - 9:10 pmGSP-SAN
9h 05m2 stops
$397Southwest
Find Deal
Sun, Nov 9 - Wed, Nov 12
American Airlines Logo
9:27 pm - 8:24 amSAN-GSP
7h 57m1 stop
American Airlines Logo
6:00 am - 10:45 amGSP-SAN
7h 45m1 stop
$414American Airlines
Find Deal
Thu, Oct 16 - Tue, Oct 21
Delta Logo
2:05 pm - 11:55 pmSAN-GSP
6h 50m1 stop
Delta Logo
7:52 am - 8:19 pmGSP-SAN
15h 27m1 stop
$421Delta
Find Deal
Tue, Oct 7 - Sun, Oct 12
Delta Logo
7:25 am - 5:41 pmSAN-GSP
7h 16m1 stop
Delta Logo
6:35 am - 11:14 pmGSP-SAN
19h 39m1 stop
$432Delta
Find Deal
Sat, Oct 11 - Sun, Oct 12
United Airlines Logo
10:15 am - 10:39 pmSAN-GSP
9h 24m1 stop
United Airlines Logo
6:05 am - 12:27 pmGSP-SAN
9h 22m1 stop
$449United Airlines
Find Deal
Thu, Oct 9 - Mon, Oct 13
United Airlines Logo
7:00 am - 8:55 pmSAN-GSP
10h 55m2 stops
United Airlines Logo
12:00 pm - 9:25 pmGSP-SAN
12h 25m1 stop
$464United Airlines
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Tue, Mar 3 - Wed, Mar 4
Alaska Airlines Logo
7:45 pm - 10:56 amSAN-GSP
12h 11m2 stops
Alaska Airlines Logo
7:34 am - 7:03 pmGSP-SAN
14h 29m2 stops
$761Alaska Airlines
Find Deal
Mon, Sep 29 - Fri, Oct 3

Southwest flights from San Diego to Greenville

Our best Southwest deals on San Diego to Greenville flight tickets
Southwest
Nov 9
SAN9:45 pmSan Diego
9h 00m
1 stop
GSP9:45 amGreenville
Nov 12
GSP3:05 pmGreenville
6h 50m
1 stop
SAN6:55 pmSan Diego
$392
Find similar
Southwest
Nov 9
SAN6:35 amSan Diego
6h 05m
1 stop
GSP3:40 pmGreenville
Nov 12
GSP3:05 pmGreenville
9h 05m
2 stops
SAN9:10 pmSan Diego
$397
Find similar
Southwest
Oct 25
SAN6:25 amSan Diego
8h 50m
2 stops
GSP6:15 pmGreenville
Nov 3
GSP4:45 pmGreenville
7h 50m
1 stop
SAN9:35 pmSan Diego
$418
Find similar

Delta flights from San Diego to Greenville

Our best Delta deals on San Diego to Greenville flight tickets
Delta
Oct 7
SAN2:05 pmSan Diego
6h 50m
1 stop
GSP11:55 pmGreenville
Oct 12
GSP7:52 amGreenville
15h 27m
1 stop
SAN8:19 pmSan Diego
$421
Find similar
Delta
Oct 11
SAN7:25 amSan Diego
7h 16m
1 stop
GSP5:41 pmGreenville
Oct 12
GSP6:35 amGreenville
19h 39m
1 stop
SAN11:14 pmSan Diego
$432
Find similar
Delta
Oct 16
SAN9:48 pmSan Diego
8h 11m
1 stop
GSP8:59 amGreenville
Oct 21
GSP6:35 amGreenville
6h 13m
1 stop
SAN9:48 amSan Diego
$438
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from San Diego to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Sat 10/25

11:46 am-9:11 pm

1 stop6h 25m

Greenville

Mon 11/3

6:01 am-11:18 am

1 stop8h 17m

$370

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Tue 9/30

6:15 am-9:54 pm

1 stop12h 39m

Greenville

Tue 10/7

11:26 am-7:23 pm

1 stop10h 57m

$390

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Sun 11/9

9:45 pm-9:45 am

1 stop9h 00m

Greenville

Wed 11/12

3:05 pm-6:55 pm

1 stop6h 50m

$392

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Sun 11/9

6:35 am-3:40 pm

1 stop6h 05m

Greenville

Wed 11/12

3:05 pm-9:10 pm

2 stops9h 05m

$397

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Thu 10/16

9:27 pm-8:24 am

1 stop7h 57m

Greenville

Tue 10/21

6:00 am-10:45 am

1 stop7h 45m

$414

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Tue 10/7

2:05 pm-11:55 pm

1 stop6h 50m

Greenville

Sun 10/12

7:52 am-8:19 pm

1 stop15h 27m

$421

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Sat 10/11

7:25 am-5:41 pm

1 stop7h 16m

Greenville

Sun 10/12

6:35 am-11:14 pm

1 stop19h 39m

$432

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Thu 10/9

10:15 am-10:39 pm

1 stop9h 24m

Greenville

Mon 10/13

6:05 am-12:27 pm

1 stop9h 22m

$449

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Tue 3/3

7:00 am-8:55 pm

2 stops10h 55m

Greenville

Wed 3/4

12:00 pm-9:25 pm

1 stop12h 25m

$464

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Mon 9/29

7:45 pm-10:56 am

2 stops12h 11m

Greenville

Fri 10/3

7:34 am-7:03 pm

2 stops14h 29m

$761

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from San Diego to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Greenville?

The month of April is another great option to travel to Greenville, with average flight prices from San Diego averaging around $362.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Wednesday is the cheapest day to fly to Greenville from San Diego. The lowest ticket price found for a Wednesday departure recently was $441. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $534. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the morning. Flights from San Diego to Greenville during this time can be as low as $464. Flights to Greenville are more costly at noon, with an average ticket price of $497. Departure times at noon fall within the peak daily travel times, which is why tickets can be more expensive.

How have San Diego to Greenville flight prices changed over time?

As of September 2025, prices for San Diego to Greenville flights are approximately 20% cheaper when compared to flights at the same time last year.

When to book flights from San Diego to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to Greenville (SAN to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Greenville

Direct flights

None
There are no direct flights from San Diego to Greenville. There are no popular flight routes from San Diego to Greenville.
Search flight deals

  • How far is San Diego to Greenville by plane?

    There are 1990.4 mi between San Diego and Greenville. A reasonable flight in good conditions will take 6h 05m.

  • When did momondo last update prices for flights from San Diego Airport to Greenville Airport?

    Prices for flights from San Diego Airport to Greenville Airport are updated daily.

  • How many operators does momondo search for flights from San Diego Airport to Greenville Airport?

  • How old do you have to be to fly from San Diego Airport to Greenville Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Diego Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The required travel and health documents for your Greenville Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Greenville Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Diego to Greenville?

Best airlines flying from San Diego to Greenville

Compare and see reviews for airlines that fly from San Diego to Greenville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $286Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $306Free CancellationRating
7.4
8,924 reviews
Search United Airlines flights
DeltaPriceFrom $312Free CancellationRating
7.9
7,957 reviews
Search Delta flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Seneca
Greer
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Greenville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Greenville from San Diego.

Can I find flights from San Diego to Greenville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for San Diego to Greenville flights to just show those with flexible booking policies.

How can momondo help me find flights from San Diego to Greenville?

momondo helps you find the best flight between San Diego and Greenville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from San Diego to Greenville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Greenville from San Diego. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Greenville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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