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Cheap flights from San Diego to Greenville from $120

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to Greenville departing on 2/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from San Diego to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:15 am - 8:43 pm
SAN
-
GSP
11h 28m1 stop
American Airlines Logo
5:19 am - 11:27 am
GSP
-
SAN
9h 08m1 stop
$359American Airlines
Tue, Feb 24 - Sat, Feb 28
American Airlines Logo
12:17 pm - 9:47 pm
SAN
-
GSP
6h 30m1 stop
American Airlines Logo
2:31 pm - 7:21 pm
GSP
-
SAN
7h 50m1 stop
$377American Airlines
Sat, Feb 14 - Sun, Feb 15
American Airlines Logo
6:20 am - 7:47 pm
SAN
-
GSP
10h 27m1 stop
American Airlines Logo
11:28 am - 8:35 pm
GSP
-
SAN
12h 07m1 stop
$393American Airlines
Thu, Mar 12 - Tue, Mar 17
American Airlines Logo
6:20 am - 11:59 pm
SAN
-
GSP
14h 39m1 stop
American Airlines Logo
4:40 pm - 10:50 pm
GSP
-
SAN
9h 10m1 stop
$400American Airlines
Fri, Jan 16 - Tue, Jan 20
United Airlines Logo
6:10 pm - 10:01 am
SAN
-
GSP
12h 51m2 stops
United Airlines Logo
2:51 pm - 8:46 pm
GSP
-
SAN
8h 55m1 stop
$412United Airlines
Sat, Feb 14 - Wed, Feb 18
United Airlines Logo
6:10 pm - 10:01 am
SAN
-
GSP
12h 51m2 stops
United Airlines Logo
10:40 am - 11:40 pm
GSP
-
SAN
16h 00m2 stops
$417United Airlines
Sat, Feb 14 - Wed, Feb 18
United Airlines Logo
10:40 pm - 11:23 am
SAN
-
GSP
9h 43m1 stop
United Airlines Logo
6:35 am - 3:04 pm
GSP
-
SAN
11h 29m2 stops
$418United Airlines
Fri, Jan 16 - Tue, Jan 20
Southwest Logo
6:20 am - 8:50 pm
SAN
-
GSP
11h 30m2 stops
Southwest Logo
12:30 pm - 8:00 pm
GSP
-
SAN
10h 30m2 stops
$422Southwest
Sat, Feb 14 - Sun, Feb 15
United Airlines Logo
6:10 pm - 10:01 am
SAN
-
GSP
12h 51m2 stops
United Airlines Logo
10:00 am - 3:41 pm
GSP
-
SAN
8h 41m1 stop
$442United Airlines
Sat, Feb 14 - Wed, Feb 18
American Airlines Logo
12:05 pm - 11:09 pm
SAN
-
GSP
8h 04m1 stop
American Airlines Logo
12:11 pm - 3:51 pm
GSP
-
SAN
6h 40m1 stop
$447American Airlines
Wed, Apr 8 - Tue, Apr 14

United Airlines flights from San Diego to Greenville

Our best United Airlines deals on San Diego to Greenville flight tickets
United Airlines
Feb 14
SAN6:10 pmSan Diego
12h 51m
2 stops
GSP10:01 amGreenville
Feb 18
GSP2:51 pmGreenville
8h 55m
1 stop
SAN8:46 pmSan Diego
$412
Find similar
United Airlines
Feb 14
SAN6:10 pmSan Diego
12h 51m
2 stops
GSP10:01 amGreenville
Feb 18
GSP10:40 amGreenville
16h 00m
2 stops
SAN11:40 pmSan Diego
$417
Find similar
United Airlines
Jan 16
SAN10:40 pmSan Diego
9h 43m
1 stop
GSP11:23 amGreenville
Jan 20
GSP6:35 amGreenville
11h 29m
2 stops
SAN3:04 pmSan Diego
$418
Find similar

American Airlines flights from San Diego to Greenville

Our best American Airlines deals on San Diego to Greenville flight tickets
American Airlines
Feb 24
SAN6:15 amSan Diego
11h 28m
1 stop
GSP8:43 pmGreenville
Feb 28
GSP5:19 amGreenville
9h 08m
1 stop
SAN11:27 amSan Diego
$359
Find similar
American Airlines
Feb 14
SAN12:17 pmSan Diego
6h 30m
1 stop
GSP9:47 pmGreenville
Feb 15
GSP2:31 pmGreenville
7h 50m
1 stop
SAN7:21 pmSan Diego
$377
Find similar
American Airlines
Mar 12
SAN6:20 amSan Diego
10h 27m
1 stop
GSP7:47 pmGreenville
Mar 17
GSP11:28 amGreenville
12h 07m
1 stop
SAN8:35 pmSan Diego
$393
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 26, 2025.
Use the filters below to find and compare flights from San Diego to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Tue 2/24

6:15 am-8:43 pm

1 stop11h 28m

Greenville

Sat 2/28

5:19 am-11:27 am

1 stop9h 08m

$359

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Sat 2/14

12:17 pm-9:47 pm

1 stop6h 30m

Greenville

Sun 2/15

2:31 pm-7:21 pm

1 stop7h 50m

$377

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Thu 3/12

6:20 am-7:47 pm

1 stop10h 27m

Greenville

Tue 3/17

11:28 am-8:35 pm

1 stop12h 07m

$393

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Fri 1/16

6:20 am-11:59 pm

1 stop14h 39m

Greenville

Tue 1/20

4:40 pm-10:50 pm

1 stop9h 10m

$400

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Sat 2/14

6:10 pm-10:01 am

2 stops12h 51m

Greenville

Wed 2/18

2:51 pm-8:46 pm

1 stop8h 55m

$412

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Sat 2/14

6:10 pm-10:01 am

2 stops12h 51m

Greenville

Wed 2/18

10:40 am-11:40 pm

2 stops16h 00m

$417

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Fri 1/16

10:40 pm-11:23 am

1 stop9h 43m

Greenville

Tue 1/20

6:35 am-3:04 pm

2 stops11h 29m

$418

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Sat 2/14

6:20 am-8:50 pm

2 stops11h 30m

Greenville

Sun 2/15

12:30 pm-8:00 pm

2 stops10h 30m

$422

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Sat 2/14

6:10 pm-10:01 am

2 stops12h 51m

Greenville

Wed 2/18

10:00 am-3:41 pm

1 stop8h 41m

$442

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Wed 4/8

12:05 pm-11:09 pm

1 stop8h 04m

Greenville

Tue 4/14

12:11 pm-3:51 pm

1 stop6h 40m

$447

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from San Diego to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Greenville?

The month of April is another great option to travel to Greenville, with average flight prices from San Diego averaging around $362.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Wednesday is the cheapest day to fly to Greenville from San Diego. The lowest ticket price found for a Wednesday departure recently was $441. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $534. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the morning. Flights from San Diego to Greenville during this time can be as low as $464. Flights to Greenville are more costly at noon, with an average ticket price of $497. Departure times at noon fall within the peak daily travel times, which is why tickets can be more expensive.

How have San Diego to Greenville flight prices changed over time?

As of December 2025, prices for San Diego to Greenville flights are approximately 30% cheaper when compared to flights at the same time last year.

When to book flights from San Diego to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to Greenville (SAN to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Greenville

Fastest flight time

7h 37m

Direct flights

None
The fastest flight from San Diego to Greenville takes 7h 37m
There are no direct flights from San Diego to Greenville. There are no popular flight routes from San Diego to Greenville.
Search flight deals

  • How far is San Diego to Greenville by plane?

    There are 1990.4 mi between San Diego and Greenville. A reasonable flight in good conditions will take 7h 37m.

  • When did momondo last update prices for flights from San Diego Airport to Greenville Airport?

    Prices for flights from San Diego Airport to Greenville Airport are updated daily.

  • How many operators does momondo search for flights from San Diego Airport to Greenville Airport?

  • How old do you have to be to fly from San Diego Airport to Greenville Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Diego Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The required travel and health documents for your Greenville Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Greenville Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Diego to Greenville?

Best airlines flying from San Diego to Greenville

Compare and see reviews for airlines that fly from San Diego to Greenville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $249Free CancellationRating
7.9
8,013 reviews
Search Delta flights
American AirlinesPriceFrom $286Free CancellationRating
7.2
11,062 reviews
Search American Airlines flights
United AirlinesPriceFrom $306Free CancellationRating
7.4
9,115 reviews
Search United Airlines flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Seneca
Greer
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Greenville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Greenville from San Diego.

Can I find flights from San Diego to Greenville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for San Diego to Greenville flights to just show those with flexible booking policies.

How can momondo help me find flights from San Diego to Greenville?

momondo helps you find the best flight between San Diego and Greenville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from San Diego to Greenville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Greenville from San Diego. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Greenville trip

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