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Cheap flights from San Diego to Greenville from $167

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to Greenville departing on 9/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from San Diego to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:15 am - 6:17 pmSAN  San Diego-GSP Greenville
9h 02m1 stop Detroit Metropolitan Wayne County
Delta Logo
8:05 am - 12:25 pmGSP  Greenville-SAN San Diego
7h 20m1 stop Atlanta Hartsfield-Jackson
$351Delta
vie., sep. 11 - mar., sep. 15
Multiple Airlines Logo
3:45 pm - 2:53 pmSAN  San Diego-GSP Greenville
20h 08m2 stops Denver Intl Orlando
Multiple Airlines Logo
10:35 am - 11:48 amGSP  Greenville-SAN San Diego
28h 13m1 stop Pittsburgh
$362Multiple Airlines
mié., ago. 26 - dom., ago. 30
American Airlines Logo
6:45 am - 4:46 pmSAN  San Diego-GSP Greenville
7h 01m1 stop Charlotte Douglas
American Airlines Logo
5:28 pm - 9:03 pmGSP  Greenville-SAN San Diego
6h 35m1 stop Dallas/Fort Worth
$368American Airlines
mar., sep. 1 - mar., sep. 8
Delta Logo
6:15 am - 4:15 pmSAN  San Diego-GSP Greenville
7h 00m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:45 am - 11:25 amGSP  Greenville-SAN San Diego
8h 40m1 stop Atlanta Hartsfield-Jackson
$368Delta
mar., sep. 1 - mar., sep. 8
American Airlines Logo
10:27 pm - 8:24 amSAN  San Diego-GSP Greenville
6h 57m1 stop Charlotte Douglas
American Airlines Logo
8:00 am - 2:17 pmGSP  Greenville-SAN San Diego
9h 17m1 stop Dallas/Fort Worth
$369American Airlines
sáb., oct. 10 - sáb., oct. 17
United Airlines Logo
6:18 am - 5:14 pmSAN  San Diego-GSP Greenville
7h 56m1 stop Chicago O'Hare Intl
United Airlines Logo
4:19 pm - 8:34 pmGSP  Greenville-SAN San Diego
7h 15m1 stop Denver Intl
$369United Airlines
jue., sep. 10 - mié., sep. 16
United Airlines Logo
10:30 pm - 9:35 amSAN  San Diego-GSP Greenville
8h 05m1 stop Chicago O'Hare Intl
United Airlines Logo
3:01 pm - 8:29 pmGSP  Greenville-SAN San Diego
8h 28m1 stop Washington, D.C. Dulles Intl
$369United Airlines
mar., sep. 8 - jue., sep. 10
Southwest Logo
8:15 am - 6:30 pmSAN  San Diego-GSP Greenville
7h 15m1 stop Nashville Intl
Southwest Logo
1:00 pm - 6:20 pmGSP  Greenville-SAN San Diego
8h 20m1 stop Baltimore/Washington
$369Southwest
mié., oct. 28 - lun., nov. 2
Southwest Logo
9:55 pm - 10:45 amSAN  San Diego-GSP Greenville
9h 50m1 stop Baltimore/Washington
Southwest Logo
6:40 am - 1:10 pmGSP  Greenville-SAN San Diego
9h 30m1 stop Nashville Intl
$369Southwest
lun., nov. 2 - lun., nov. 9
Breeze Airways Logo
12:24 pm - 11:26 amSAN  San Diego-GSP Greenville
20h 02m1 stop Cincinnati Cinci./N. Kentucky
Breeze Airways Logo
10:35 am - 11:48 amGSP  Greenville-SAN San Diego
28h 13m1 stop Pittsburgh
$487Breeze Airways
jue., ago. 20 - dom., ago. 23

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American Airlines flights from San Diego to Greenville

Our best American Airlines deals on San Diego to Greenville flight tickets
American Airlines
Sep 23
SAN6:15 amSan Diego
7h 19m
1 stop
GSP4:34 pmGreenville
Sep 30
GSP5:24 pmGreenville
7h 24m
1 stop
SAN9:48 pmSan Diego
$369
American Airlines
Sep 4
SAN12:06 pmSan Diego
7h 11m
1 stop
GSP10:17 pmGreenville
Sep 6
GSP8:05 pmGreenville
6h 54m
1 stop
SAN11:59 pmSan Diego
$378
American Airlines
Sep 24
SAN12:08 pmSan Diego
7h 03m
1 stop
GSP10:11 pmGreenville
Oct 1
GSP5:24 pmGreenville
7h 24m
1 stop
SAN9:48 pmSan Diego
$444

Southwest flights from San Diego to Greenville

Our best Southwest deals on San Diego to Greenville flight tickets
Southwest
Sep 2
SAN8:05 amSan Diego
9h 50m
2 stops
GSP8:55 pmGreenville
Sep 9
GSP5:30 pmGreenville
6h 20m
1 stop
SAN8:50 pmSan Diego
$373
Southwest
Oct 10
SAN9:50 pmSan Diego
8h 55m
1 stop
GSP9:45 amGreenville
Oct 17
GSP6:40 amGreenville
9h 20m
2 stops
SAN1:00 pmSan Diego
$374
Southwest
Oct 10
SAN8:00 amSan Diego
9h 35m
2 stops
GSP8:35 pmGreenville
Oct 17
GSP6:40 amGreenville
9h 20m
2 stops
SAN1:00 pmSan Diego
$379

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated agosto 7, 2026.
Use the filters below to find and compare flights from San Diego to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San DiegoGreenville

SAN San Diego - GSP Greenville

SANGSP

San Diego

vie. 9/11

6:15 am-6:17 pm

1 stop9h 02m

Greenville

mar. 9/15

8:05 am-12:25 pm

1 stop7h 20m

$351

San DiegoGreenville

SAN San Diego - GSP Greenville

SANGSP

San Diego

mié. 8/26

3:45 pm-2:53 pm

2 stops20h 08m

Greenville

dom. 8/30

10:35 am-11:48 am

1 stop28h 13m

$362
Quickest round-trip

San DiegoGreenville

SAN San Diego - GSP Greenville

SANGSP

San Diego

mar. 9/1

6:45 am-4:46 pm

1 stop7h 01m

Greenville

mar. 9/8

5:28 pm-9:03 pm

1 stop6h 35m

$368

San DiegoGreenville

SAN San Diego - GSP Greenville

SANGSP

San Diego

mar. 9/1

6:15 am-4:15 pm

1 stop7h 00m

Greenville

mar. 9/8

5:45 am-11:25 am

1 stop8h 40m

$368

San DiegoGreenville

SAN San Diego - GSP Greenville

SANGSP

San Diego

sáb. 10/10

10:27 pm-8:24 am

1 stop6h 57m

Greenville

sáb. 10/17

8:00 am-2:17 pm

1 stop9h 17m

$369

San DiegoGreenville

SAN San Diego - GSP Greenville

SANGSP

San Diego

jue. 9/10

6:18 am-5:14 pm

1 stop7h 56m

Greenville

mié. 9/16

4:19 pm-8:34 pm

1 stop7h 15m

$369

San DiegoGreenville

SAN San Diego - GSP Greenville

SANGSP

San Diego

mar. 9/8

10:30 pm-9:35 am

1 stop8h 05m

Greenville

jue. 9/10

3:01 pm-8:29 pm

1 stop8h 28m

$369

San DiegoGreenville

SAN San Diego - GSP Greenville

SANGSP

San Diego

mié. 10/28

8:15 am-6:30 pm

1 stop7h 15m

Greenville

lun. 11/2

1:00 pm-6:20 pm

1 stop8h 20m

$369

San DiegoGreenville

SAN San Diego - GSP Greenville

SANGSP

San Diego

lun. 11/2

9:55 pm-10:45 am

1 stop9h 50m

Greenville

lun. 11/9

6:40 am-1:10 pm

1 stop9h 30m

$369

San DiegoGreenville

SAN San Diego - GSP Greenville

SANGSP

San Diego

jue. 8/20

12:24 pm-11:26 am

1 stop20h 02m

Greenville

dom. 8/23

10:35 am-11:48 am

1 stop28h 13m

$487

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from San Diego to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Diego and Greenville?

Prices are currently low for flights on this route.

Typical prices usually range from $399 to $633.
The lowest price recently found on this route was $351.

What is the cheapest month to fly to Greenville?

The month of May is another great option to travel to Greenville, with average flight prices from San Diego averaging around $443.

How have San Diego to Greenville flight prices changed over time?

As of August 2026, prices for San Diego to Greenville flights are approximately 4% cheaper when compared to flights at the same time last year.

When to book flights from San Diego to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to Greenville (SAN to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Greenville

Fastest flight time

6h 56m

Direct flights

None
The fastest flight from San Diego to Greenville takes 6h 56m
There are no direct flights from San Diego to Greenville. There are no popular flight routes from San Diego to Greenville.
Search flight deals

Frequently asked questions about flying from San Diego to Greenville

  • How far is San Diego to Greenville by plane?

    There are 1990.4 mi between San Diego and Greenville. A reasonable flight in good conditions will take 6h 56m.

  • When did momondo last update prices for flights from San Diego Airport to Greenville Airport?

    Prices for flights from San Diego Airport to Greenville Airport are updated daily.

  • How many operators does momondo search for flights from San Diego Airport to Greenville Airport?

  • How old do you have to be to fly from San Diego Airport to Greenville Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Diego Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The required travel and health documents for your Greenville Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Greenville Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Diego to Greenville?

Best airlines flying from San Diego to Greenville

Compare and see reviews for airlines that fly from San Diego to Greenville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $303Free CancellationRating
7.1
11,874 reviews
Search American Airlines flights
DeltaPriceFrom $312Free CancellationRating
7.8
8,499 reviews
Search Delta flights
United AirlinesPriceFrom $358Free CancellationRating
7.4
10,081 reviews
Search United Airlines flights
SouthwestPriceFrom $405Free CancellationRating
8.0
4,216 reviews
Search Southwest flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Greer
Seneca
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Greenville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Greenville from San Diego.

Can I find flights from San Diego to Greenville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for San Diego to Greenville flights to just show those with flexible booking policies.

How can momondo help me find flights from San Diego to Greenville?

momondo helps you find the best flight between San Diego and Greenville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from San Diego to Greenville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Greenville from San Diego. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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dom. 9/6
dom. 9/13
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