Cheap flights from San Diego to Florence from $699

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to Florence departing on 12/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.

Find the cheapest flights from San Diego to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:15 am - 7:38 pm
SAN
-
FLO
10h 23m2 stops
American Airlines Logo
5:15 am - 3:24 pm
FLO
-
SAN
13h 09m2 stops
$699American Airlines
Wed, Dec 31 - Sun, Jan 4
American Airlines Logo
6:15 am - 6:05 pm
SAN
-
FLO
8h 50m1 stop
American Airlines Logo
5:15 am - 12:04 pm
FLO
-
SAN
9h 49m2 stops
$714American Airlines
Wed, Dec 31 - Sun, Jan 4
American Airlines Logo
6:15 am - 6:05 pm
SAN
-
FLO
8h 50m1 stop
American Airlines Logo
1:07 pm - 6:56 pm
FLO
-
SAN
8h 49m1 stop
$871American Airlines
Wed, Dec 31 - Sun, Jan 4

American Airlines flights from San Diego to Florence, South Carolina

Our best American Airlines deals on San Diego to Florence, South Carolina flight tickets
American Airlines
Dec 31
SAN6:15 amSan Diego
10h 23m
2 stops
FLO7:38 pmFlorence
Jan 4
FLO5:15 amFlorence
13h 09m
2 stops
SAN3:24 pmSan Diego
American Airlines
Dec 31
SAN6:15 amSan Diego
8h 50m
1 stop
FLO6:05 pmFlorence
Jan 4
FLO5:15 amFlorence
9h 49m
2 stops
SAN12:04 pmSan Diego
American Airlines
Dec 31
SAN6:15 amSan Diego
8h 50m
1 stop
FLO6:05 pmFlorence
Jan 4
FLO1:07 pmFlorence
8h 49m
1 stop
SAN6:56 pmSan Diego

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from San Diego to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Wed 12/31

6:15 am-7:38 pm

2 stops10h 23m

Florence

Sun 1/4

5:15 am-3:24 pm

2 stops13h 09m

$699

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Wed 12/31

6:15 am-6:05 pm

1 stop8h 50m

Florence

Sun 1/4

5:15 am-12:04 pm

2 stops9h 49m

$714

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Wed 12/31

6:15 am-6:05 pm

1 stop8h 50m

Florence

Sun 1/4

1:07 pm-6:56 pm

1 stop8h 49m

$871

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from San Diego to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Florence, South Carolina?

On average, the least expensive day to fly to Florence, South Carolina from San Diego is on a Tuesday. momondo users have found tickets for Tuesday departures for as low as $577. However, this price may fluctuate depending on the airline, the season, and holidays. On the other hand, Friday is the most expensive day to depart from San Diego because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $759.

What is the cheapest time of day to depart on your flight to Florence, South Carolina?

According to our data, the cheapest time of day to fly to Florence, South Carolina is at noon. momondo users have found flights departing from San Diego to Florence, South Carolina at noon for as low as $491. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. In the morning is when there is more demand to fly to Florence, South Carolina, so prices are often more expensive at around $749 per ticket.

When to book flights from San Diego to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to Florence, South Carolina (SAN to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Florence, South Carolina

Fastest flight time

10h 23m

Direct flights

None
The fastest flight from San Diego to Florence, South Carolina takes 10h 23m
There are no direct flights from San Diego to Florence, South Carolina. There are no popular flight routes from San Diego to Florence, South Carolina.
  • How far is San Diego to Florence by plane?

    The straight-line distance from San Diego to Florence is 2144.5 mi. A reasonable flight in good conditions will take 10h 23m.

  • When did momondo last update prices for flights from San Diego Airport to Florence Airport?

    Prices for flights from San Diego Airport to Florence Airport are refreshed on a daily basis.

  • How old do you have to be to fly from San Diego Airport to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from San Diego Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Florence?

It is quick and easy to find San Diego to Florence flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Florence that suits you.

Can I find flights from San Diego to Florence with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Florence from San Diego with this policy.

How can momondo help me find flights from San Diego to Florence?

Once you have performed a search for San Diego to Florence flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from San Diego to Florence right now. Can momondo alert me if prices change?

If you are not ready to book a flight from San Diego to Florence now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Florence and let you know when they change.

An easier way to manage your Florence, South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sat 1/17
Sat 1/24

Find better results for your trip to the United States