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Cheap flights from San Diego to Florence from $512

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to Florence departing on 6/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Diego to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:15 am - 10:00 pm
SAN
-
FLO
12h 45m
2 stops
American Airlines Logo
2:35 pm - 6:50 pm
FLO
-
SAN
7h 15m
1 stop
$530American Airlines
Sat, May 23 - Sat, May 30
American Airlines Logo
7:15 am - 10:00 pm
SAN
-
FLO
11h 45m
2 stops
American Airlines Logo
5:05 am - 2:20 pm
FLO
-
SAN
12h 15m
2 stops
$535American Airlines
Sat, May 23 - Sat, May 30
American Airlines Logo
6:15 am - 5:50 pm
SAN
-
FLO
8h 35m
1 stop
American Airlines Logo
5:20 am - 11:09 am
FLO
-
SAN
8h 49m
1 stop
$572American Airlines
Sat, Apr 4 - Sat, Apr 25
American Airlines Logo
10:49 am - 11:57 pm
SAN
-
FLO
10h 08m
2 stops
American Airlines Logo
4:16 pm - 8:50 pm
FLO
-
SAN
7h 34m
1 stop
$577American Airlines
Sat, Apr 4 - Sat, Apr 25
American Airlines Logo
9:00 am - 11:57 pm
SAN
-
FLO
11h 57m
2 stops
American Airlines Logo
5:20 am - 12:14 pm
FLO
-
SAN
9h 54m
2 stops
$582American Airlines
Sat, Apr 4 - Sat, Apr 25
American Airlines Logo
6:15 am - 5:50 pm
SAN
-
FLO
8h 35m
1 stop
American Airlines Logo
5:20 am - 11:13 am
FLO
-
SAN
8h 53m
1 stop
$599American Airlines
Sat, Apr 4 - Sun, Apr 26
American Airlines Logo
8:00 am - 11:57 pm
SAN
-
FLO
12h 57m
2 stops
American Airlines Logo
4:16 pm - 8:50 pm
FLO
-
SAN
7h 34m
1 stop
$604American Airlines
Sat, Apr 4 - Sun, Apr 26
American Airlines Logo
12:03 pm - 9:47 pm
SAN
-
FLO
6h 44m
1 stop
American Airlines Logo
5:20 am - 11:13 am
FLO
-
SAN
8h 53m
1 stop
$641American Airlines
Thu, Apr 9 - Thu, Apr 23
American Airlines Logo
6:15 am - 9:47 pm
SAN
-
FLO
12h 32m
2 stops
American Airlines Logo
5:20 am - 11:13 am
FLO
-
SAN
8h 53m
1 stop
$646American Airlines
Thu, Apr 9 - Thu, Apr 23
American Airlines Logo
6:15 am - 9:47 pm
SAN
-
FLO
12h 32m
2 stops
American Airlines Logo
4:16 pm - 11:56 pm
FLO
-
SAN
10h 40m
2 stops
$651American Airlines
Thu, Apr 9 - Thu, Apr 23

American Airlines flights from San Diego to Florence, South Carolina

Our best American Airlines deals on San Diego to Florence, South Carolina flight tickets
American Airlines
May 23
SAN6:15 amSan Diego
12h 45m
2 stops
FLO10:00 pmFlorence
May 30
FLO2:35 pmFlorence
7h 15m
1 stop
SAN6:50 pmSan Diego
$530
American Airlines
May 23
SAN7:15 amSan Diego
11h 45m
2 stops
FLO10:00 pmFlorence
May 30
FLO5:05 amFlorence
12h 15m
2 stops
SAN2:20 pmSan Diego
$535
American Airlines
Apr 4
SAN6:15 amSan Diego
8h 35m
1 stop
FLO5:50 pmFlorence
Apr 25
FLO5:20 amFlorence
8h 49m
1 stop
SAN11:09 amSan Diego
$572

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 24, 2026.
Use the filters below to find and compare flights from San Diego to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Sat 5/23

6:15 am-10:00 pm

2 stops12h 45m

Florence

Sat 5/30

2:35 pm-6:50 pm

1 stop7h 15m

$530

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Sat 5/23

7:15 am-10:00 pm

2 stops11h 45m

Florence

Sat 5/30

5:05 am-2:20 pm

2 stops12h 15m

$535

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Sat 4/4

6:15 am-5:50 pm

1 stop8h 35m

Florence

Sat 4/25

5:20 am-11:09 am

1 stop8h 49m

$572

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Sat 4/4

10:49 am-11:57 pm

2 stops10h 08m

Florence

Sat 4/25

4:16 pm-8:50 pm

1 stop7h 34m

$577

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Sat 4/4

9:00 am-11:57 pm

2 stops11h 57m

Florence

Sat 4/25

5:20 am-12:14 pm

2 stops9h 54m

$582

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Sat 4/4

6:15 am-5:50 pm

1 stop8h 35m

Florence

Sun 4/26

5:20 am-11:13 am

1 stop8h 53m

$599

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Sat 4/4

8:00 am-11:57 pm

2 stops12h 57m

Florence

Sun 4/26

4:16 pm-8:50 pm

1 stop7h 34m

$604
Quickest round-trip

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Thu 4/9

12:03 pm-9:47 pm

1 stop6h 44m

Florence

Thu 4/23

5:20 am-11:13 am

1 stop8h 53m

$641

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Thu 4/9

6:15 am-9:47 pm

2 stops12h 32m

Florence

Thu 4/23

5:20 am-11:13 am

1 stop8h 53m

$646

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Thu 4/9

6:15 am-9:47 pm

2 stops12h 32m

Florence

Thu 4/23

4:16 pm-11:56 pm

2 stops10h 40m

$651

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from San Diego to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from San Diego to Florence?

American Airlines is the most popular carrier operating from San Diego to Florence

What airlines fly to Florence, South Carolina?

American Airlines, Delta and Southwest are the top three most popular airlines that fly to Florence, South Carolina from San Diego according to our data. American Airlines is the first choice among our users, with 71% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 8 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from San Diego to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to Florence, South Carolina (SAN to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Florence, South Carolina

Fastest flight time

6h 44m

Direct flights

None
The fastest flight from San Diego to Florence, South Carolina takes 6h 44m
There are no direct flights from San Diego to Florence, South Carolina. There are no popular flight routes from San Diego to Florence, South Carolina.
Search flight deals

  • How far is San Diego to Florence by plane?

    The straight-line distance from San Diego to Florence is 2144.5 mi. A reasonable flight in good conditions will take 6h 44m.

  • When did momondo last update prices for flights from San Diego Airport to Florence Airport?

    Prices for flights from San Diego Airport to Florence Airport are refreshed on a daily basis.

  • How old do you have to be to fly from San Diego Airport to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from San Diego Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Lake City
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Florence?

It is quick and easy to find San Diego to Florence flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Florence that suits you.

Can I find flights from San Diego to Florence with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Florence from San Diego with this policy.

How can momondo help me find flights from San Diego to Florence?

Once you have performed a search for San Diego to Florence flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from San Diego to Florence right now. Can momondo alert me if prices change?

If you are not ready to book a flight from San Diego to Florence now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Florence and let you know when they change.

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