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Cheap flights from San Diego to Florence from $409

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to Florence departing on 11/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from San Diego to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
12:47 pm - 10:59 pmSAN  San Diego-FLO Florence
7h 12m1 stop Charlotte Douglas
American Airlines Logo
1:43 pm - 7:17 pmFLO  Florence-SAN San Diego
8h 34m1 stop Charlotte Douglas
$535American Airlines
Tue, Sep 1 - Sat, Sep 19
American Airlines Logo
6:19 am - 10:59 pmSAN  San Diego-FLO Florence
13h 40m2 stops Dallas/Fort Worth Charlotte Douglas
American Airlines Logo
1:43 pm - 7:17 pmFLO  Florence-SAN San Diego
8h 34m1 stop Charlotte Douglas
$551American Airlines
Tue, Sep 1 - Sat, Sep 19
American Airlines Logo
6:19 am - 10:59 pmSAN  San Diego-FLO Florence
13h 40m2 stops Dallas/Fort Worth Charlotte Douglas
American Airlines Logo
6:24 am - 5:47 pmFLO  Florence-SAN San Diego
14h 23m2 stops Charlotte Douglas Dallas/Fort Worth
$567American Airlines
Tue, Sep 1 - Sat, Sep 19
American Airlines Logo
12:47 pm - 10:59 pmSAN  San Diego-FLO Florence
7h 12m1 stop Charlotte Douglas
American Airlines Logo
1:43 pm - 7:17 pmFLO  Florence-SAN San Diego
8h 34m1 stop Charlotte Douglas
$582American Airlines
Tue, Sep 1 - Sat, Sep 19
American Airlines Logo
6:25 am - 10:59 pmSAN  San Diego-FLO Florence
13h 34m2 stops Phoenix Sky Harbor Intl Charlotte Douglas
American Airlines Logo
1:43 pm - 7:17 pmFLO  Florence-SAN San Diego
8h 34m1 stop Charlotte Douglas
$600American Airlines
Tue, Sep 1 - Sat, Sep 19
American Airlines Logo
12:47 pm - 10:59 pmSAN  San Diego-FLO Florence
7h 12m1 stop Charlotte Douglas
American Airlines Logo
6:22 am - 10:07 amFLO  Florence-SAN San Diego
6h 45m1 stop Charlotte Douglas
$619American Airlines
Tue, Sep 1 - Mon, Sep 7
American Airlines Logo
6:25 am - 10:59 pmSAN  San Diego-FLO Florence
13h 34m2 stops Phoenix Sky Harbor Intl Charlotte Douglas
American Airlines Logo
6:24 am - 6:16 pmFLO  Florence-SAN San Diego
14h 52m2 stops Charlotte Douglas Phoenix Sky Harbor Intl
$634American Airlines
Tue, Sep 1 - Sat, Sep 19
American Airlines Logo
6:25 am - 10:59 pmSAN  San Diego-FLO Florence
13h 34m2 stops Phoenix Sky Harbor Intl Charlotte Douglas
American Airlines Logo
6:22 am - 10:07 amFLO  Florence-SAN San Diego
6h 45m1 stop Charlotte Douglas
$637American Airlines
Tue, Sep 1 - Mon, Sep 7
American Airlines Logo
6:25 am - 10:59 pmSAN  San Diego-FLO Florence
13h 34m2 stops Phoenix Sky Harbor Intl Charlotte Douglas
American Airlines Logo
6:22 am - 3:26 pmFLO  Florence-SAN San Diego
12h 04m2 stops Charlotte Douglas Phoenix Sky Harbor Intl
$682American Airlines
Tue, Sep 1 - Mon, Sep 7

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American Airlines flights from San Diego to Florence, South Carolina

Our best American Airlines deals on San Diego to Florence, South Carolina flight tickets
American Airlines
Sep 1
SAN12:47 pmSan Diego
7h 12m
1 stop
FLO10:59 pmFlorence
Sep 19
FLO1:43 pmFlorence
8h 34m
1 stop
SAN7:17 pmSan Diego
$535
American Airlines
Sep 1
SAN6:19 amSan Diego
13h 40m
2 stops
FLO10:59 pmFlorence
Sep 19
FLO1:43 pmFlorence
8h 34m
1 stop
SAN7:17 pmSan Diego
$551
American Airlines
Sep 1
SAN6:19 amSan Diego
13h 40m
2 stops
FLO10:59 pmFlorence
Sep 19
FLO6:24 amFlorence
14h 23m
2 stops
SAN5:47 pmSan Diego
$567

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 5, 2026.
Use the filters below to find and compare flights from San Diego to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San DiegoFlorence

SAN San Diego - FLO Florence

SANFLO

San Diego

Tue 9/1

12:47 pm-10:59 pm

1 stop7h 12m

Florence

Sat 9/19

1:43 pm-7:17 pm

1 stop8h 34m

$535

San DiegoFlorence

SAN San Diego - FLO Florence

SANFLO

San Diego

Tue 9/1

6:19 am-10:59 pm

2 stops13h 40m

Florence

Sat 9/19

1:43 pm-7:17 pm

1 stop8h 34m

$551

San DiegoFlorence

SAN San Diego - FLO Florence

SANFLO

San Diego

Tue 9/1

6:19 am-10:59 pm

2 stops13h 40m

Florence

Sat 9/19

6:24 am-5:47 pm

2 stops14h 23m

$567

San DiegoFlorence

SAN San Diego - FLO Florence

SANFLO

San Diego

Tue 9/1

12:47 pm-10:59 pm

1 stop7h 12m

Florence

Sat 9/19

1:43 pm-7:17 pm

1 stop8h 34m

$582

San DiegoFlorence

SAN San Diego - FLO Florence

SANFLO

San Diego

Tue 9/1

6:25 am-10:59 pm

2 stops13h 34m

Florence

Sat 9/19

1:43 pm-7:17 pm

1 stop8h 34m

$600
Quickest round-trip

San DiegoFlorence

SAN San Diego - FLO Florence

SANFLO

San Diego

Tue 9/1

12:47 pm-10:59 pm

1 stop7h 12m

Florence

Mon 9/7

6:22 am-10:07 am

1 stop6h 45m

$619

San DiegoFlorence

SAN San Diego - FLO Florence

SANFLO

San Diego

Tue 9/1

6:25 am-10:59 pm

2 stops13h 34m

Florence

Sat 9/19

6:24 am-6:16 pm

2 stops14h 52m

$634

San DiegoFlorence

SAN San Diego - FLO Florence

SANFLO

San Diego

Tue 9/1

6:25 am-10:59 pm

2 stops13h 34m

Florence

Mon 9/7

6:22 am-10:07 am

1 stop6h 45m

$637

San DiegoFlorence

SAN San Diego - FLO Florence

SANFLO

San Diego

Tue 9/1

6:25 am-10:59 pm

2 stops13h 34m

Florence

Mon 9/7

6:22 am-3:26 pm

2 stops12h 04m

$682
Cheapest one-way

San DiegoFlorence

SAN San Diego - FLO Florence

SANFLO

San Diego

Thu 11/12

10:40 pm-2:10 pm

2 stops12h 30m

$409

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 11 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from San Diego to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from San Diego to Florence?

American Airlines is the most popular carrier operating from San Diego to Florence

What airlines fly to Florence, South Carolina?

American Airlines, Delta and Southwest are the top three most popular airlines that fly to Florence, South Carolina from San Diego according to our data. American Airlines is the first choice among our users, with 69% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 7 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from San Diego to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to Florence, South Carolina (SAN to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Florence, South Carolina

Fastest flight time

7h 12m

Direct flights

None
The fastest flight from San Diego to Florence, South Carolina takes 7h 12m
There are no direct flights from San Diego to Florence, South Carolina. There are no popular flight routes from San Diego to Florence, South Carolina.
Search flight deals

Frequently asked questions about flying from San Diego to Florence, South Carolina

  • How far is San Diego to Florence by plane?

    The straight-line distance from San Diego to Florence is 2144.5 mi. A reasonable flight in good conditions will take 7h 12m.

  • When did momondo last update prices for flights from San Diego Airport to Florence Airport?

    Prices for flights from San Diego Airport to Florence Airport are refreshed on a daily basis.

  • How old do you have to be to fly from San Diego Airport to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from San Diego Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Darlington
Hartsville
Lake City
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Florence?

It is quick and easy to find San Diego to Florence flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Florence that suits you.

Can I find flights from San Diego to Florence with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Florence from San Diego with this policy.

How can momondo help me find flights from San Diego to Florence?

Once you have performed a search for San Diego to Florence flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from San Diego to Florence right now. Can momondo alert me if prices change?

If you are not ready to book a flight from San Diego to Florence now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Florence and let you know when they change.

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