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Cheap flights from San Diego to Florence from $492

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to Florence departing on 12/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
1:44 pm - 12:15 amSAN-FLO
7h 31m1 stop
American Airlines Logo
6:15 am - 11:52 amFLO-SAN
8h 37m1 stop
$492American Airlines
Find Deal
Sat, Dec 6 - Mon, Dec 8
American Airlines Logo
1:44 pm - 12:15 amSAN-FLO
7h 31m1 stop
American Airlines Logo
6:15 am - 3:21 pmFLO-SAN
12h 06m2 stops
$497American Airlines
Find Deal
Sat, Dec 6 - Mon, Dec 8
American Airlines Logo
10:07 am - 12:15 amSAN-FLO
11h 08m2 stops
American Airlines Logo
6:15 am - 3:21 pmFLO-SAN
12h 06m2 stops
$502American Airlines
Find Deal
Sat, Dec 6 - Mon, Dec 8
American Airlines Logo
12:09 pm - 11:38 pmSAN-FLO
8h 29m1 stop
American Airlines Logo
11:09 am - 6:32 pmFLO-SAN
10h 23m1 stop
$632American Airlines
Find Deal
Wed, Mar 25 - Sat, Mar 28
American Airlines Logo
7:52 pm - 10:24 amSAN-FLO
11h 32m2 stops
American Airlines Logo
5:13 am - 11:10 amFLO-SAN
8h 57m1 stop
$637American Airlines
Find Deal
Wed, Mar 25 - Sat, Mar 28
American Airlines Logo
10:24 am - 11:38 pmSAN-FLO
10h 14m2 stops
American Airlines Logo
5:13 am - 2:51 pmFLO-SAN
12h 38m2 stops
$642American Airlines
Find Deal
Wed, Mar 25 - Sat, Mar 28
American Airlines Logo
12:01 pm - 11:41 pmSAN-FLO
8h 40m1 stop
American Airlines Logo
5:15 am - 11:11 amFLO-SAN
8h 56m1 stop
$851American Airlines
Find Deal
Wed, Nov 26 - Mon, Dec 1
American Airlines Logo
10:09 am - 11:41 pmSAN-FLO
10h 32m2 stops
American Airlines Logo
5:15 am - 11:11 amFLO-SAN
8h 56m1 stop
$876American Airlines
Find Deal
Wed, Nov 26 - Mon, Dec 1
American Airlines Logo
10:09 am - 11:41 pmSAN-FLO
10h 32m2 stops
American Airlines Logo
5:15 am - 12:45 pmFLO-SAN
10h 30m2 stops
$953American Airlines
Find Deal
Wed, Nov 26 - Mon, Dec 1

American Airlines flights from San Diego to Florence, South Carolina

Our best American Airlines deals on San Diego to Florence, South Carolina flight tickets
American Airlines
Dec 6
SAN1:44 pmSan Diego
7h 31m
1 stop
FLO12:15 amFlorence
Dec 8
FLO6:15 amFlorence
8h 37m
1 stop
SAN11:52 amSan Diego
$492
Find similar
American Airlines
Dec 6
SAN1:44 pmSan Diego
7h 31m
1 stop
FLO12:15 amFlorence
Dec 8
FLO6:15 amFlorence
12h 06m
2 stops
SAN3:21 pmSan Diego
$497
Find similar
American Airlines
Dec 6
SAN10:07 amSan Diego
11h 08m
2 stops
FLO12:15 amFlorence
Dec 8
FLO6:15 amFlorence
12h 06m
2 stops
SAN3:21 pmSan Diego
$502
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from San Diego to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Sat 12/6

1:44 pm-12:15 am

1 stop7h 31m

Florence

Mon 12/8

6:15 am-11:52 am

1 stop8h 37m

$492

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Sat 12/6

1:44 pm-12:15 am

1 stop7h 31m

Florence

Mon 12/8

6:15 am-3:21 pm

2 stops12h 06m

$497

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Sat 12/6

10:07 am-12:15 am

2 stops11h 08m

Florence

Mon 12/8

6:15 am-3:21 pm

2 stops12h 06m

$502

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Wed 3/25

12:09 pm-11:38 pm

1 stop8h 29m

Florence

Sat 3/28

11:09 am-6:32 pm

1 stop10h 23m

$632

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Wed 3/25

7:52 pm-10:24 am

2 stops11h 32m

Florence

Sat 3/28

5:13 am-11:10 am

1 stop8h 57m

$637

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Wed 3/25

10:24 am-11:38 pm

2 stops10h 14m

Florence

Sat 3/28

5:13 am-2:51 pm

2 stops12h 38m

$642

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Wed 11/26

12:01 pm-11:41 pm

1 stop8h 40m

Florence

Mon 12/1

5:15 am-11:11 am

1 stop8h 56m

$851

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Wed 11/26

10:09 am-11:41 pm

2 stops10h 32m

Florence

Mon 12/1

5:15 am-11:11 am

1 stop8h 56m

$876

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Wed 11/26

10:09 am-11:41 pm

2 stops10h 32m

Florence

Mon 12/1

5:15 am-12:45 pm

2 stops10h 30m

$953

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from San Diego to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Florence, South Carolina?

On average, the least expensive day to fly to Florence, South Carolina from San Diego is on a Tuesday. momondo users have found tickets for Tuesday departures for as low as $577. However, this price may fluctuate depending on the airline, the season, and holidays. On the other hand, Friday is the most expensive day to depart from San Diego because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $759.

What is the cheapest time of day to depart on your flight to Florence, South Carolina?

According to our data, the cheapest time of day to fly to Florence, South Carolina is at noon. momondo users have found flights departing from San Diego to Florence, South Carolina at noon for as low as $491. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. In the morning is when there is more demand to fly to Florence, South Carolina, so prices are often more expensive at around $749 per ticket.

When to book flights from San Diego to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to Florence, South Carolina (SAN to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Florence, South Carolina

Direct flights

None
There are no direct flights from San Diego to Florence, South Carolina. There are no popular flight routes from San Diego to Florence, South Carolina.
Search flight deals

  • How far is San Diego to Florence by plane?

    The straight-line distance from San Diego to Florence is 2144.5 mi. A reasonable flight in good conditions will take 7h 31m.

  • When did momondo last update prices for flights from San Diego Airport to Florence Airport?

    Prices for flights from San Diego Airport to Florence Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Diego Airport to Florence Airport?

  • How old do you have to be to fly from San Diego Airport to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from San Diego Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from San Diego to Florence, South Carolina?

Best airlines flying from San Diego to Florence, South Carolina

Compare and see reviews for airlines that fly from San Diego to Florence, South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $351Free CancellationRating
7.2
11,038 reviews
Search American Airlines flights

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Florence?

It is quick and easy to find San Diego to Florence flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Florence that suits you.

Can I find flights from San Diego to Florence with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Florence from San Diego with this policy.

How can momondo help me find flights from San Diego to Florence?

Once you have performed a search for San Diego to Florence flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from San Diego to Florence right now. Can momondo alert me if prices change?

If you are not ready to book a flight from San Diego to Florence now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Florence and let you know when they change.

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