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Cheap flights from Rome to Los Angeles from $461

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Rome to Los Angeles departing on 12/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

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Multiple Airlines Logo
7:05 am - 11:25 amFCO-SNA
37h 20m2 stops
Multiple Airlines Logo
7:00 am - 9:25 amSNA-FCO
17h 25m2 stops
$622Multiple Airlines
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Fri, Nov 21 - Fri, Dec 5
American Airlines Logo
1:10 pm - 8:42 amFCO-SNA
28h 32m2 stops
American Airlines Logo
11:55 am - 2:55 pmSNA-FCO
18h 00m2 stops
$641American Airlines
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Fri, Feb 20 - Mon, Feb 23
American Airlines Logo
1:10 pm - 8:34 amFCO-SNA
28h 24m2 stops
American Airlines Logo
1:42 pm - 7:35 pmSNA-FCO
20h 53m2 stops
$642American Airlines
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Fri, Feb 20 - Mon, Feb 23
United Airlines Logo
9:45 am - 8:53 pmFCO-SNA
20h 08m2 stops
United Airlines Logo
6:45 am - 7:45 amSNA-FCO
16h 00m1 stop
$643United Airlines
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Sat, Nov 8 - Mon, Dec 1
United Airlines Logo
9:45 am - 8:53 pmFCO-SNA
20h 08m2 stops
United Airlines Logo
8:00 am - 1:25 pmSNA-FCO
20h 25m2 stops
$748United Airlines
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Sat, Nov 8 - Sun, Nov 30
Multiple Airlines Logo
11:00 am - 8:03 pmFCO-SNA
18h 03m1 stop
Multiple Airlines Logo
7:35 am - 9:00 amSNA-FCO
16h 25m2 stops
$753Multiple Airlines
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Fri, Nov 21 - Fri, Dec 5
Brussels Airlines Logo
9:45 am - 6:57 pmFCO-SNA
18h 12m1 stop
Brussels Airlines Logo
6:45 am - 7:45 amSNA-FCO
16h 00m1 stop
$775Brussels Airlines
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Fri, Feb 20 - Mon, Feb 23
Lufthansa Logo
2:20 pm - 8:40 pmFCO-SNA
15h 20m1 stop
Lufthansa Logo
1:20 pm - 12:20 pmSNA-FCO
14h 00m1 stop
$786Lufthansa
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Wed, Apr 1 - Fri, Apr 10
Lufthansa Logo
10:00 am - 7:35 pmFCO-SNA
18h 35m2 stops
Lufthansa Logo
1:20 pm - 12:20 pmSNA-FCO
14h 00m1 stop
$804Lufthansa
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Wed, Apr 1 - Fri, Apr 10
Iberia Logo
8:20 pm - 8:32 amFCO-SNA
21h 12m2 stops
Iberia Logo
10:41 am - 10:45 amSNA-FCO
15h 04m1 stop
$1,150Iberia
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Fri, Nov 21 - Fri, Dec 5

American Airlines flights from Rome to Santa Ana, California

Our best American Airlines deals on Rome to Santa Ana, California flight tickets
American Airlines
Feb 20
FCO1:10 pmRome Fiumicino
28h 32m
2 stops
SNA8:42 amSanta Ana J. Wayne/Orange Cnty
Feb 23
SNA11:55 amSanta Ana J. Wayne/Orange Cnty
18h 00m
2 stops
FCO2:55 pmRome Fiumicino
$641
Find similar
American Airlines
Feb 20
FCO1:10 pmRome Fiumicino
28h 24m
2 stops
SNA8:34 amSanta Ana J. Wayne/Orange Cnty
Feb 23
SNA1:42 pmSanta Ana J. Wayne/Orange Cnty
20h 53m
2 stops
FCO7:35 pmRome Fiumicino
$642
Find similar

United Airlines flights from Rome to Santa Ana, California

Our best United Airlines deals on Rome to Santa Ana, California flight tickets
United Airlines
Nov 8
FCO9:45 amRome Fiumicino
20h 08m
2 stops
SNA8:53 pmSanta Ana J. Wayne/Orange Cnty
Dec 1
SNA6:45 amSanta Ana J. Wayne/Orange Cnty
16h 00m
1 stop
FCO7:45 amRome Fiumicino
$643
Find similar
United Airlines
Nov 8
FCO9:45 amRome Fiumicino
20h 08m
2 stops
SNA8:53 pmSanta Ana J. Wayne/Orange Cnty
Nov 30
SNA8:00 amSanta Ana J. Wayne/Orange Cnty
20h 25m
2 stops
FCO1:25 pmRome Fiumicino
$748
Find similar
United Airlines
Feb 20
FCO9:45 amRome Fiumicino
20h 05m
2 stops
SNA8:50 pmSanta Ana J. Wayne/Orange Cnty
Feb 23
SNA6:45 amSanta Ana J. Wayne/Orange Cnty
16h 00m
1 stop
FCO7:45 amRome Fiumicino
$776
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Rome to Santa Ana, California that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 26, 2025.
Use the filters below to find and compare flights from Rome to Santa Ana, California that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

RomeSanta Ana

FCO - SNA

FCOSNA

Rome Fiumicino

Fri 11/21

7:05 am-11:25 am

2 stops37h 20m

Santa Ana J. Wayne/Orange Cnty

Fri 12/5

7:00 am-9:25 am

2 stops17h 25m

$622

RomeSanta Ana

FCO - SNA

FCOSNA

Rome Fiumicino

Fri 2/20

1:10 pm-8:42 am

2 stops28h 32m

Santa Ana J. Wayne/Orange Cnty

Mon 2/23

11:55 am-2:55 pm

2 stops18h 00m

$641

RomeSanta Ana

FCO - SNA

FCOSNA

Rome Fiumicino

Fri 2/20

1:10 pm-8:34 am

2 stops28h 24m

Santa Ana J. Wayne/Orange Cnty

Mon 2/23

1:42 pm-7:35 pm

2 stops20h 53m

$642

RomeSanta Ana

FCO - SNA

FCOSNA

Rome Fiumicino

Sat 11/8

9:45 am-8:53 pm

2 stops20h 08m

Santa Ana J. Wayne/Orange Cnty

Mon 12/1

6:45 am-7:45 am

1 stop16h 00m

$643

RomeSanta Ana

FCO - SNA

FCOSNA

Rome Fiumicino

Sat 11/8

9:45 am-8:53 pm

2 stops20h 08m

Santa Ana J. Wayne/Orange Cnty

Sun 11/30

8:00 am-1:25 pm

2 stops20h 25m

$748

RomeSanta Ana

FCO - SNA

FCOSNA

Rome Fiumicino

Fri 11/21

11:00 am-8:03 pm

1 stop18h 03m

Santa Ana J. Wayne/Orange Cnty

Fri 12/5

7:35 am-9:00 am

2 stops16h 25m

$753

RomeSanta Ana

FCO - SNA

FCOSNA

Rome Fiumicino

Fri 2/20

9:45 am-6:57 pm

1 stop18h 12m

Santa Ana J. Wayne/Orange Cnty

Mon 2/23

6:45 am-7:45 am

1 stop16h 00m

$775

RomeSanta Ana

FCO - SNA

FCOSNA

Rome Fiumicino

Wed 4/1

2:20 pm-8:40 pm

1 stop15h 20m

Santa Ana J. Wayne/Orange Cnty

Fri 4/10

1:20 pm-12:20 pm

1 stop14h 00m

$786

RomeSanta Ana

FCO - SNA

FCOSNA

Rome Fiumicino

Wed 4/1

10:00 am-7:35 pm

2 stops18h 35m

Santa Ana J. Wayne/Orange Cnty

Fri 4/10

1:20 pm-12:20 pm

1 stop14h 00m

$804

RomeSanta Ana

FCO - SNA

FCOSNA

Rome Fiumicino

Fri 11/21

8:20 pm-8:32 am

2 stops21h 12m

Santa Ana J. Wayne/Orange Cnty

Fri 12/5

10:41 am-10:45 am

1 stop15h 04m

$1,150

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Rome to Santa Ana, California

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Rome to Santa Ana, California flights?

You could potentially save up to 4% on your flight if you consider stops on a Rome to Santa Ana, California flight.

When to book flights from Rome to Santa Ana, California

Are you open to changing your travel dates? Check out the ideal times to fly from Rome to Santa Ana, California according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Rome to Santa Ana, California (ROM to SNA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Rome to Santa Ana, California

Direct flights

None
There are no direct flights from Rome to Santa Ana, California. There are no popular flight routes from Rome to Santa Ana, California.
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  • How far is Rome to Santa Ana J. Wayne/Orange Cnty by plane?

    Rome and Santa Ana J. Wayne/Orange Cnty are 6331.7 mi apart from one another. In terms of flight time, this usually takes a little over 15h 20m.

  • When did momondo last update prices for flights from Rome to Santa Ana J. Wayne/Orange Cnty Airport?

    Prices for flights from Rome to Santa Ana J. Wayne/Orange Cnty Airport were last updated today.

  • How old do you have to be to fly from Rome to Santa Ana J. Wayne/Orange Cnty Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Rome to Santa Ana J. Wayne/Orange Cnty Airport.

  • What documentation or ID do you need to fly to Santa Ana J. Wayne/Orange Cnty Airport?

    The travel and health documents required for your trip to Santa Ana J. Wayne/Orange Cnty Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Santa Ana J. Wayne/Orange Cnty Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Los Angeles?

Book flights to Los Angeles if you plan to visit one of these locations
Anaheim
Tustin

Why use momondo?

Why should I use momondo to find a flight deal from Rome to Santa Ana?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Rome to Santa Ana. momondo saves you time and could save you money on your trip.

Can I find flights from Rome to Santa Ana with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Santa Ana from Rome with this policy.

How can momondo help me find flights from Rome to Santa Ana?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Santa Ana from Rome.

I’m not ready to book a flight from Rome to Santa Ana right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Santa Ana, momondo offers a useful price alert feature which will track prices for flights to Santa Ana from Rome and alert you when they change.

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