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Cheap flights from Orlando Airport to Florence from $402

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Orlando Airport to Florence departing on 7/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Orlando Airport to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
3:32 pm - 10:00 pm
MCO
-
FLO
6h 28m
1 stop
American Airlines Logo
5:05 am - 9:06 am
FLO
-
MCO
4h 01m
1 stop
$507American Airlines
Tue, Jun 16 - Wed, Jun 24
American Airlines Logo
9:57 am - 2:10 pm
MCO
-
FLO
4h 13m
1 stop
American Airlines Logo
5:17 am - 9:13 am
FLO
-
MCO
3h 56m
1 stop
$515American Airlines
Thu, Jun 25 - Thu, Jul 2
American Airlines Logo
6:00 am - 2:10 pm
MCO
-
FLO
8h 10m
2 stops
American Airlines Logo
5:17 am - 9:13 am
FLO
-
MCO
3h 56m
1 stop
$520American Airlines
Thu, Jun 25 - Thu, Jul 2
American Airlines Logo
7:34 am - 2:10 pm
MCO
-
FLO
6h 36m
2 stops
American Airlines Logo
2:35 pm - 11:59 pm
FLO
-
MCO
9h 24m
2 stops
$525American Airlines
Thu, Jun 25 - Thu, Jul 2
American Airlines Logo
9:57 am - 2:10 pm
MCO
-
FLO
4h 13m
1 stop
American Airlines Logo
5:05 am - 9:06 am
FLO
-
MCO
4h 01m
1 stop
$597American Airlines
Thu, Jun 18 - Mon, Jun 22
American Airlines Logo
1:41 pm - 10:00 pm
MCO
-
FLO
8h 19m
2 stops
American Airlines Logo
2:35 pm - 6:41 pm
FLO
-
MCO
4h 06m
1 stop
$632American Airlines
Tue, Jun 16 - Wed, Jun 24
American Airlines Logo
6:00 am - 2:10 pm
MCO
-
FLO
8h 10m
2 stops
American Airlines Logo
2:35 pm - 9:15 pm
FLO
-
MCO
6h 40m
2 stops
$687American Airlines
Tue, Jun 16 - Wed, Jun 24
American Airlines Logo
7:34 am - 2:10 pm
MCO
-
FLO
6h 36m
2 stops
American Airlines Logo
5:05 am - 9:06 am
FLO
-
MCO
4h 01m
1 stop
$723American Airlines
Thu, Jun 18 - Mon, Jun 22
American Airlines Logo
10:58 am - 10:00 pm
MCO
-
FLO
11h 02m
2 stops
American Airlines Logo
2:35 pm - 11:59 pm
FLO
-
MCO
9h 24m
2 stops
$812American Airlines
Thu, Jun 18 - Mon, Jun 22

American Airlines flights from Orlando Airport to Florence, South Carolina

Our best American Airlines deals on Orlando Airport to Florence, South Carolina flight tickets
American Airlines
Jun 16
MCO3:32 pmOrlando
6h 28m
1 stop
FLO10:00 pmFlorence
Jun 24
FLO5:05 amFlorence
4h 01m
1 stop
MCO9:06 amOrlando
$507
American Airlines
Jun 25
MCO9:57 amOrlando
4h 13m
1 stop
FLO2:10 pmFlorence
Jul 2
FLO5:17 amFlorence
3h 56m
1 stop
MCO9:13 amOrlando
$515
American Airlines
Jun 25
MCO6:00 amOrlando
8h 10m
2 stops
FLO2:10 pmFlorence
Jul 2
FLO5:17 amFlorence
3h 56m
1 stop
MCO9:13 amOrlando
$520

momondo Fare Finder

 
Customize your flight search to find flights from Orlando Airport to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 30, 2026.
Use the filters below to find and compare flights from Orlando Airport to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Tue 6/16

3:32 pm-10:00 pm

1 stop6h 28m

Florence

Wed 6/24

5:05 am-9:06 am

1 stop4h 01m

$507
Quickest round-trip

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Thu 6/25

9:57 am-2:10 pm

1 stop4h 13m

Florence

Thu 7/2

5:17 am-9:13 am

1 stop3h 56m

$515

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Thu 6/25

6:00 am-2:10 pm

2 stops8h 10m

Florence

Thu 7/2

5:17 am-9:13 am

1 stop3h 56m

$520

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Thu 6/25

7:34 am-2:10 pm

2 stops6h 36m

Florence

Thu 7/2

2:35 pm-11:59 pm

2 stops9h 24m

$525

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Thu 6/18

9:57 am-2:10 pm

1 stop4h 13m

Florence

Mon 6/22

5:05 am-9:06 am

1 stop4h 01m

$597

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Tue 6/16

1:41 pm-10:00 pm

2 stops8h 19m

Florence

Wed 6/24

2:35 pm-6:41 pm

1 stop4h 06m

$632

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Tue 6/16

6:00 am-2:10 pm

2 stops8h 10m

Florence

Wed 6/24

2:35 pm-9:15 pm

2 stops6h 40m

$687

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Thu 6/18

7:34 am-2:10 pm

2 stops6h 36m

Florence

Mon 6/22

5:05 am-9:06 am

1 stop4h 01m

$723

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Thu 6/18

10:58 am-10:00 pm

2 stops11h 02m

Florence

Mon 6/22

2:35 pm-11:59 pm

2 stops9h 24m

$812
Cheapest one-way
Quickest one-way

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Wed 7/8

3:32 pm-8:07 pm

1 stop4h 35m

$402

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Orlando Airport to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Orlando to Florence?

American Airlines is the most popular carrier operating from Orlando to Florence

What airlines fly to Florence, South Carolina?

Frontier, Spirit Airlines and American Airlines are the top three most popular airlines that fly to Florence, South Carolina from Orlando Airport according to our data. Frontier is the first choice among our users, with 43% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 5 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Orlando Airport to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Orlando Airport to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Orlando Airport to Florence, South Carolina (MCO to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Orlando Airport to Florence, South Carolina

Fastest flight time

4h 13m

Direct flights

None
The fastest flight from Orlando Airport to Florence, South Carolina takes 4h 13m
There are no direct flights from Orlando Airport to Florence, South Carolina. There are no popular flight routes from Orlando Airport to Florence, South Carolina.
Search flight deals

Frequently asked questions about flying from Orlando Airport to Florence, South Carolina

  • How far is Orlando to Florence by plane?

    Florence is 408.3 mi away from Orlando. By plane, this route typically takes 4h 13m.

  • When did momondo last update prices for flights from Orlando Airport to Florence Airport?

    Prices for flights from Orlando Airport to Florence Airport refresh daily.

  • How old do you have to be to fly from Orlando Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Orlando Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Darlington
Hartsville
Lake City
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Orlando to Florence?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Orlando to Florence for you.

Can I find flights from Orlando to Florence with flexible booking policies on momondo?

Yes. All flights to Florence from Orlando on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Orlando to Florence?

momondo helps you find the best flight between Orlando and Florence by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Orlando to Florence right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Florence from Orlando. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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