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Cheap flights from Orlando Airport to Florence from $414

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Orlando Airport to Florence departing on 3/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Orlando Airport to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:40 am - 5:50 pm
MCO
-
FLO
11h 10m
2 stops
American Airlines Logo
5:16 am - 5:05 pm
FLO
-
MCO
11h 49m
2 stops
$414American Airlines
Sat, Mar 7 - Wed, Mar 11
American Airlines Logo
5:37 pm - 11:57 pm
MCO
-
FLO
6h 20m
1 stop
American Airlines Logo
5:16 am - 9:28 am
FLO
-
MCO
4h 12m
1 stop
$467American Airlines
Sat, Mar 7 - Wed, Mar 11
American Airlines Logo
7:52 pm - 11:57 pm
MCO
-
FLO
4h 05m
1 stop
American Airlines Logo
5:16 am - 3:02 pm
FLO
-
MCO
9h 46m
2 stops
$472American Airlines
Sat, Mar 7 - Wed, Mar 11

American Airlines flights from Orlando Airport to Florence, South Carolina

Our best American Airlines deals on Orlando Airport to Florence, South Carolina flight tickets
American Airlines
Mar 7
MCO6:40 amOrlando
11h 10m
2 stops
FLO5:50 pmFlorence
Mar 11
FLO5:16 amFlorence
11h 49m
2 stops
MCO5:05 pmOrlando
$414
American Airlines
Mar 7
MCO5:37 pmOrlando
6h 20m
1 stop
FLO11:57 pmFlorence
Mar 11
FLO5:16 amFlorence
4h 12m
1 stop
MCO9:28 amOrlando
$467
American Airlines
Mar 7
MCO7:52 pmOrlando
4h 05m
1 stop
FLO11:57 pmFlorence
Mar 11
FLO5:16 amFlorence
9h 46m
2 stops
MCO3:02 pmOrlando
$472

momondo Fare Finder

 
Customize your flight search to find flights from Orlando Airport to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 23, 2026.
Use the filters below to find and compare flights from Orlando Airport to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Sat 3/7

6:40 am-5:50 pm

2 stops11h 10m

Florence

Wed 3/11

5:16 am-5:05 pm

2 stops11h 49m

$414

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Sat 3/7

5:37 pm-11:57 pm

1 stop6h 20m

Florence

Wed 3/11

5:16 am-9:28 am

1 stop4h 12m

$467

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Sat 3/7

7:52 pm-11:57 pm

1 stop4h 05m

Florence

Wed 3/11

5:16 am-3:02 pm

2 stops9h 46m

$472

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Orlando Airport to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Florence, South Carolina?

Frontier, Spirit Airlines and American Airlines are the top three most popular airlines that fly to Florence, South Carolina from Orlando Airport according to our data. Frontier is the first choice among our users, with 39% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 5 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Orlando Airport to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Orlando Airport to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Orlando Airport to Florence, South Carolina (MCO to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Orlando Airport to Florence, South Carolina

Fastest flight time

4h 05m

Direct flights

None
The fastest flight from Orlando Airport to Florence, South Carolina takes 4h 05m
There are no direct flights from Orlando Airport to Florence, South Carolina. There are no popular flight routes from Orlando Airport to Florence, South Carolina.
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  • How far is Orlando to Florence by plane?

    Florence is 408.3 mi away from Orlando. By plane, this route typically takes 4h 05m.

  • When did momondo last update prices for flights from Orlando Airport to Florence Airport?

    Prices for flights from Orlando Airport to Florence Airport refresh daily.

  • How old do you have to be to fly from Orlando Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Orlando Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Orlando to Florence?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Orlando to Florence for you.

Can I find flights from Orlando to Florence with flexible booking policies on momondo?

Yes. All flights to Florence from Orlando on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Orlando to Florence?

momondo helps you find the best flight between Orlando and Florence by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Orlando to Florence right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Florence from Orlando. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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