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Cheap flights from Orlando Airport to Florence from $395

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Orlando Airport to Florence departing on 11/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

American Airlines Logo
4:27 pm - 10:53 pmMCO-FLO
6h 26m1 stop
American Airlines Logo
6:15 am - 11:21 amFLO-MCO
5h 06m1 stop
$395American Airlines
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Wed, Nov 12 - Wed, Nov 19
American Airlines Logo
4:27 pm - 10:53 pmMCO-FLO
6h 26m1 stop
American Airlines Logo
10:29 am - 7:24 pmFLO-MCO
8h 55m2 stops
$400American Airlines
Find Deal
Wed, Nov 12 - Wed, Nov 19
American Airlines Logo
3:01 pm - 10:53 pmMCO-FLO
7h 52m2 stops
American Airlines Logo
10:29 am - 8:25 pmFLO-MCO
9h 56m2 stops
$405American Airlines
Find Deal
Wed, Nov 12 - Wed, Nov 19
American Airlines Logo
5:00 am - 10:24 amMCO-FLO
5h 24m1 stop
American Airlines Logo
2:30 pm - 6:01 pmFLO-MCO
3h 31m1 stop
$467American Airlines
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Wed, Mar 25 - Sat, Mar 28
American Airlines Logo
7:58 am - 2:05 pmMCO-FLO
6h 07m2 stops
American Airlines Logo
5:13 am - 8:53 amFLO-MCO
3h 40m1 stop
$472American Airlines
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Wed, Mar 25 - Sat, Mar 28
American Airlines Logo
12:00 pm - 6:05 pmMCO-FLO
6h 05m1 stop
American Airlines Logo
5:15 am - 9:40 amFLO-MCO
4h 25m1 stop
$475American Airlines
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Fri, Dec 26 - Thu, Jan 1
American Airlines Logo
8:24 am - 2:04 pmMCO-FLO
5h 40m1 stop
American Airlines Logo
6:14 am - 1:50 pmFLO-MCO
7h 36m2 stops
$477American Airlines
Find Deal
Fri, Oct 10 - Tue, Oct 14
American Airlines Logo
5:31 pm - 12:15 amMCO-FLO
6h 44m1 stop
American Airlines Logo
5:15 am - 1:27 pmFLO-MCO
8h 12m2 stops
$480American Airlines
Find Deal
Fri, Dec 26 - Thu, Jan 1
American Airlines Logo
6:00 am - 2:04 pmMCO-FLO
8h 04m2 stops
American Airlines Logo
3:19 pm - 11:59 pmFLO-MCO
8h 40m2 stops
$482American Airlines
Find Deal
Fri, Oct 10 - Tue, Oct 14
American Airlines Logo
6:21 am - 2:05 pmMCO-FLO
7h 44m2 stops
American Airlines Logo
2:30 pm - 12:09 amFLO-MCO
9h 39m2 stops
$496American Airlines
Find Deal
Wed, Mar 25 - Sat, Mar 28

American Airlines flights from Orlando Airport to Florence, South Carolina

Our best American Airlines deals on Orlando Airport to Florence, South Carolina flight tickets
American Airlines
Nov 12
MCO4:27 pmOrlando
6h 26m
1 stop
FLO10:53 pmFlorence
Nov 19
FLO6:15 amFlorence
5h 06m
1 stop
MCO11:21 amOrlando
$395
Find similar
American Airlines
Nov 12
MCO4:27 pmOrlando
6h 26m
1 stop
FLO10:53 pmFlorence
Nov 19
FLO10:29 amFlorence
8h 55m
2 stops
MCO7:24 pmOrlando
$400
Find similar
American Airlines
Nov 12
MCO3:01 pmOrlando
7h 52m
2 stops
FLO10:53 pmFlorence
Nov 19
FLO10:29 amFlorence
9h 56m
2 stops
MCO8:25 pmOrlando
$405
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Orlando Airport to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 26, 2025.
Use the filters below to find and compare flights from Orlando Airport to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Wed 11/12

4:27 pm-10:53 pm

1 stop6h 26m

Florence

Wed 11/19

6:15 am-11:21 am

1 stop5h 06m

$395

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Wed 11/12

4:27 pm-10:53 pm

1 stop6h 26m

Florence

Wed 11/19

10:29 am-7:24 pm

2 stops8h 55m

$400

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Wed 11/12

3:01 pm-10:53 pm

2 stops7h 52m

Florence

Wed 11/19

10:29 am-8:25 pm

2 stops9h 56m

$405

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Wed 3/25

5:00 am-10:24 am

1 stop5h 24m

Florence

Sat 3/28

2:30 pm-6:01 pm

1 stop3h 31m

$467

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Wed 3/25

7:58 am-2:05 pm

2 stops6h 07m

Florence

Sat 3/28

5:13 am-8:53 am

1 stop3h 40m

$472

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Fri 12/26

12:00 pm-6:05 pm

1 stop6h 05m

Florence

Thu 1/1

5:15 am-9:40 am

1 stop4h 25m

$475

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Fri 10/10

8:24 am-2:04 pm

1 stop5h 40m

Florence

Tue 10/14

6:14 am-1:50 pm

2 stops7h 36m

$477

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Fri 12/26

5:31 pm-12:15 am

1 stop6h 44m

Florence

Thu 1/1

5:15 am-1:27 pm

2 stops8h 12m

$480

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Fri 10/10

6:00 am-2:04 pm

2 stops8h 04m

Florence

Tue 10/14

3:19 pm-11:59 pm

2 stops8h 40m

$482

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Wed 3/25

6:21 am-2:05 pm

2 stops7h 44m

Florence

Sat 3/28

2:30 pm-12:09 am

2 stops9h 39m

$496

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

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How to get the cheapest flight ticket from Orlando Airport to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest time of day to depart on your flight to Florence, South Carolina?

According to our data, the cheapest time of day to fly to Florence, South Carolina is in the morning. momondo users have found flights departing from Orlando Airport to Florence, South Carolina in the morning for as low as $462. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. In the afternoon is when there is more demand to fly to Florence, South Carolina, so prices are often more expensive at around $590 per ticket.

When to book flights from Orlando Airport to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Orlando Airport to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Orlando Airport to Florence, South Carolina (MCO to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Orlando Airport to Florence, South Carolina

Direct flights

None
There are no direct flights from Orlando Airport to Florence, South Carolina. There are no popular flight routes from Orlando Airport to Florence, South Carolina.
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  • How far is Orlando to Florence by plane?

    Florence is 408.3 mi away from Orlando. By plane, this route typically takes 5h 24m.

  • When did momondo last update prices for flights from Orlando Airport to Florence Airport?

    Prices for flights from Orlando Airport to Florence Airport refresh daily.

  • How old do you have to be to fly from Orlando Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Orlando Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Orlando to Florence?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Orlando to Florence for you.

Can I find flights from Orlando to Florence with flexible booking policies on momondo?

Yes. All flights to Florence from Orlando on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Orlando to Florence?

momondo helps you find the best flight between Orlando and Florence by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Orlando to Florence right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Florence from Orlando. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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