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Cheap flights from Orlando Airport to Florence from $402

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Orlando Airport to Florence departing on 6/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Orlando Airport to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
10:00 am - 3:32 pm
MCO
-
FLO
5h 32m
1 stop
American Airlines Logo
5:20 am - 9:36 am
FLO
-
MCO
4h 16m
1 stop
$507American Airlines
Tue, Apr 28 - Sat, May 2
American Airlines Logo
11:12 am - 10:42 pm
MCO
-
FLO
11h 30m
2 stops
American Airlines Logo
4:16 pm - 9:59 pm
FLO
-
MCO
5h 43m
1 stop
$512American Airlines
Tue, Apr 28 - Sat, May 2
American Airlines Logo
7:00 am - 3:32 pm
MCO
-
FLO
8h 32m
2 stops
American Airlines Logo
5:20 am - 3:08 pm
FLO
-
MCO
9h 48m
2 stops
$517American Airlines
Tue, Apr 28 - Sat, May 2

American Airlines flights from Orlando Airport to Florence, South Carolina

Our best American Airlines deals on Orlando Airport to Florence, South Carolina flight tickets
American Airlines
Apr 28
MCO10:00 amOrlando
5h 32m
1 stop
FLO3:32 pmFlorence
May 2
FLO5:20 amFlorence
4h 16m
1 stop
MCO9:36 amOrlando
$507
American Airlines
Apr 28
MCO11:12 amOrlando
11h 30m
2 stops
FLO10:42 pmFlorence
May 2
FLO4:16 pmFlorence
5h 43m
1 stop
MCO9:59 pmOrlando
$512
American Airlines
Apr 28
MCO7:00 amOrlando
8h 32m
2 stops
FLO3:32 pmFlorence
May 2
FLO5:20 amFlorence
9h 48m
2 stops
MCO3:08 pmOrlando
$517

momondo Fare Finder

 
Customize your flight search to find flights from Orlando Airport to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 14, 2026.
Use the filters below to find and compare flights from Orlando Airport to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Tue 4/28

10:00 am-3:32 pm

1 stop5h 32m

Florence

Sat 5/2

5:20 am-9:36 am

1 stop4h 16m

$507

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Tue 4/28

11:12 am-10:42 pm

2 stops11h 30m

Florence

Sat 5/2

4:16 pm-9:59 pm

1 stop5h 43m

$512

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Tue 4/28

7:00 am-3:32 pm

2 stops8h 32m

Florence

Sat 5/2

5:20 am-3:08 pm

2 stops9h 48m

$517
Cheapest one-way

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Sat 6/20

3:32 pm-10:00 pm

1 stop6h 28m

$402

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Sat 6/20

7:34 am-2:10 pm

2 stops6h 36m

$407

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Sun 6/21

3:32 pm-10:00 pm

1 stop6h 28m

$427

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Sun 6/21

7:34 am-2:10 pm

2 stops6h 36m

$432
Quickest one-way

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Mon 6/22

9:00 am-2:10 pm

1 stop5h 10m

$447

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Mon 6/22

10:58 am-10:00 pm

2 stops11h 02m

$516

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Orlando Airport to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Orlando to Florence?

American Airlines is the most popular carrier operating from Orlando to Florence

What airlines fly to Florence, South Carolina?

Frontier, Spirit Airlines and American Airlines are the top three most popular airlines that fly to Florence, South Carolina from Orlando Airport according to our data. Frontier is the first choice among our users, with 40% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 5 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Orlando Airport to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Orlando Airport to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Orlando Airport to Florence, South Carolina (MCO to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Orlando Airport to Florence, South Carolina

Fastest flight time

5h 32m

Direct flights

None
The fastest flight from Orlando Airport to Florence, South Carolina takes 5h 32m
There are no direct flights from Orlando Airport to Florence, South Carolina. There are no popular flight routes from Orlando Airport to Florence, South Carolina.
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Frequently asked questions about flying from Orlando Airport to Florence, South Carolina

  • How far is Orlando to Florence by plane?

    Florence is 408.3 mi away from Orlando. By plane, this route typically takes 5h 32m.

  • When did momondo last update prices for flights from Orlando Airport to Florence Airport?

    Prices for flights from Orlando Airport to Florence Airport refresh daily.

  • How old do you have to be to fly from Orlando Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Orlando Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Lake City
Darlington
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Orlando to Florence?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Orlando to Florence for you.

Can I find flights from Orlando to Florence with flexible booking policies on momondo?

Yes. All flights to Florence from Orlando on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Orlando to Florence?

momondo helps you find the best flight between Orlando and Florence by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Orlando to Florence right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Florence from Orlando. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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