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Cheap flights from Orlando Airport to Florence from $318

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Orlando Airport to Florence departing on 8/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Orlando Airport to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
10:57 am - 2:56 pm
MCO
-
FLO
3h 59m
1 stop
American Airlines Logo
6:22 am - 12:31 pm
FLO
-
MCO
6h 09m
1 stop
$447American Airlines
Sat, Aug 22 - Sat, Aug 29
American Airlines Logo
7:00 am - 1:18 pm
MCO
-
FLO
6h 18m
1 stop
American Airlines Logo
5:09 am - 11:44 am
FLO
-
MCO
6h 35m
1 stop
$481American Airlines
Wed, Sep 16 - Sun, Oct 4
American Airlines Logo
12:01 pm - 10:59 pm
MCO
-
FLO
10h 58m
2 stops
American Airlines Logo
2:35 pm - 8:21 pm
FLO
-
MCO
5h 46m
1 stop
$503American Airlines
Sat, Nov 14 - Sat, Nov 21
American Airlines Logo
5:36 pm - 10:59 pm
MCO
-
FLO
5h 23m
1 stop
American Airlines Logo
3:22 pm - 8:07 pm
FLO
-
MCO
4h 45m
1 stop
$515American Airlines
Fri, Aug 28 - Mon, Aug 31
American Airlines Logo
11:50 am - 10:58 pm
MCO
-
FLO
11h 08m
2 stops
American Airlines Logo
2:36 pm - 8:59 pm
FLO
-
MCO
6h 23m
1 stop
$527American Airlines
Wed, Sep 16 - Sun, Oct 4
American Airlines Logo
5:30 pm - 12:03 am
MCO
-
FLO
6h 33m
1 stop
American Airlines Logo
6:33 pm - 9:58 pm
FLO
-
MCO
3h 25m
1 stop
$532American Airlines
Sat, Nov 21 - Sat, Nov 28
American Airlines Logo
11:50 am - 10:58 pm
MCO
-
FLO
11h 08m
2 stops
American Airlines Logo
2:36 pm - 8:59 pm
FLO
-
MCO
6h 23m
1 stop
$537American Airlines
Wed, Sep 16 - Sun, Oct 4
American Airlines Logo
9:28 am - 3:09 pm
MCO
-
FLO
5h 41m
1 stop
American Airlines Logo
5:09 am - 9:21 am
FLO
-
MCO
4h 12m
1 stop
$551American Airlines
Sat, Nov 14 - Fri, Nov 20
American Airlines Logo
5:35 pm - 11:37 pm
MCO
-
FLO
6h 02m
1 stop
American Airlines Logo
5:17 am - 9:13 am
FLO
-
MCO
3h 56m
1 stop
$552American Airlines
Fri, Jul 31 - Tue, Aug 4
American Airlines Logo
5:35 pm - 11:37 pm
MCO
-
FLO
6h 02m
1 stop
American Airlines Logo
3:22 pm - 7:25 pm
FLO
-
MCO
4h 03m
1 stop
$577American Airlines
Tue, Aug 4 - Wed, Aug 12

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American Airlines flights from Orlando Airport to Florence, South Carolina

Our best American Airlines deals on Orlando Airport to Florence, South Carolina flight tickets
American Airlines
Aug 22
MCO10:57 amOrlando
3h 59m
1 stop
FLO2:56 pmFlorence
Aug 29
FLO6:22 amFlorence
6h 09m
1 stop
MCO12:31 pmOrlando
$447
American Airlines
Sep 16
MCO7:00 amOrlando
6h 18m
1 stop
FLO1:18 pmFlorence
Oct 4
FLO5:09 amFlorence
6h 35m
1 stop
MCO11:44 amOrlando
$481
American Airlines
Nov 14
MCO12:01 pmOrlando
10h 58m
2 stops
FLO10:59 pmFlorence
Nov 21
FLO2:35 pmFlorence
5h 46m
1 stop
MCO8:21 pmOrlando
$503

momondo Fare Finder

 
Customize your flight search to find flights from Orlando Airport to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 21, 2026.
Use the filters below to find and compare flights from Orlando Airport to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Sat 8/22

10:57 am-2:56 pm

1 stop3h 59m

Florence

Sat 8/29

6:22 am-12:31 pm

1 stop6h 09m

$447

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Wed 9/16

7:00 am-1:18 pm

1 stop6h 18m

Florence

Sun 10/4

5:09 am-11:44 am

1 stop6h 35m

$481

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Sat 11/14

12:01 pm-10:59 pm

2 stops10h 58m

Florence

Sat 11/21

2:35 pm-8:21 pm

1 stop5h 46m

$503

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Fri 8/28

5:36 pm-10:59 pm

1 stop5h 23m

Florence

Mon 8/31

3:22 pm-8:07 pm

1 stop4h 45m

$515

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Wed 9/16

11:50 am-10:58 pm

2 stops11h 08m

Florence

Sun 10/4

2:36 pm-8:59 pm

1 stop6h 23m

$527

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Sat 11/21

5:30 pm-12:03 am

1 stop6h 33m

Florence

Sat 11/28

6:33 pm-9:58 pm

1 stop3h 25m

$532

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Wed 9/16

11:50 am-10:58 pm

2 stops11h 08m

Florence

Sun 10/4

2:36 pm-8:59 pm

1 stop6h 23m

$537
Quickest round-trip

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Sat 11/14

9:28 am-3:09 pm

1 stop5h 41m

Florence

Fri 11/20

5:09 am-9:21 am

1 stop4h 12m

$551

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Fri 7/31

5:35 pm-11:37 pm

1 stop6h 02m

Florence

Tue 8/4

5:17 am-9:13 am

1 stop3h 56m

$552

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Tue 8/4

5:35 pm-11:37 pm

1 stop6h 02m

Florence

Wed 8/12

3:22 pm-7:25 pm

1 stop4h 03m

$577

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Orlando Airport to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Orlando to Florence?

American Airlines is the most popular carrier operating from Orlando to Florence

What airlines fly to Florence, South Carolina?

Frontier, Breeze Airways and American Airlines are the top three most popular airlines that fly to Florence, South Carolina from Orlando Airport according to our data. Frontier is the first choice among our users, with 58% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 4 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Orlando Airport to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Orlando Airport to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Orlando Airport to Florence, South Carolina (MCO to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Orlando Airport to Florence, South Carolina

Fastest flight time

3h 46m

Direct flights

None
The fastest flight from Orlando Airport to Florence, South Carolina takes 3h 46m
There are no direct flights from Orlando Airport to Florence, South Carolina. There are no popular flight routes from Orlando Airport to Florence, South Carolina.
Search flight deals

Frequently asked questions about flying from Orlando Airport to Florence, South Carolina

  • How far is Orlando to Florence by plane?

    Florence is 408.3 mi away from Orlando. By plane, this route typically takes 3h 46m.

  • When did momondo last update prices for flights from Orlando Airport to Florence Airport?

    Prices for flights from Orlando Airport to Florence Airport refresh daily.

  • How old do you have to be to fly from Orlando Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Orlando Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Darlington
Hartsville
Lake City
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Orlando to Florence?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Orlando to Florence for you.

Can I find flights from Orlando to Florence with flexible booking policies on momondo?

Yes. All flights to Florence from Orlando on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Orlando to Florence?

momondo helps you find the best flight between Orlando and Florence by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Orlando to Florence right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Florence from Orlando. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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