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Cheap flights from Manchester, New Hampshire to Des Moines from $170

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Manchester, New Hampshire to Des Moines departing on 8/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Manchester, New Hampshire to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
8:15 am - 12:34 pm
MHT
-
DSM
5h 19m
1 stop
American Airlines Logo
5:40 am - 2:17 pm
DSM
-
MHT
7h 37m
1 stop
$398American Airlines
Thu, Aug 20 - Sun, Aug 23
American Airlines Logo
5:12 pm - 11:44 pm
MHT
-
DSM
7h 32m
1 stop
American Airlines Logo
1:09 pm - 10:05 pm
DSM
-
MHT
7h 56m
1 stop
$428American Airlines
Fri, Aug 14 - Mon, Aug 17
United Airlines Logo
9:25 am - 5:18 pm
MHT
-
DSM
8h 53m
2 stops
United Airlines Logo
5:45 am - 7:00 pm
DSM
-
MHT
12h 15m
2 stops
$439United Airlines
Tue, Sep 1 - Sat, Sep 5
United Airlines Logo
9:25 am - 5:28 pm
MHT
-
DSM
9h 03m
2 stops
United Airlines Logo
6:00 am - 7:00 pm
DSM
-
MHT
12h 00m
2 stops
$439United Airlines
Sat, Aug 29 - Sat, Sep 5
American Airlines Logo
5:41 pm - 12:20 am
MHT
-
DSM
7h 39m
1 stop
American Airlines Logo
6:10 am - 4:38 pm
DSM
-
MHT
9h 28m
2 stops
$443American Airlines
Thu, Aug 20 - Sun, Aug 23
United Airlines Logo
2:46 pm - 11:44 pm
MHT
-
DSM
9h 58m
2 stops
United Airlines Logo
1:21 pm - 11:59 pm
DSM
-
MHT
9h 38m
2 stops
$474United Airlines
Thu, Aug 20 - Sun, Aug 23
Southwest Logo
5:50 pm - 9:55 pm
MHT
-
DSM
5h 05m
1 stop
Southwest Logo
5:20 am - 11:00 am
DSM
-
MHT
4h 40m
1 stop
$478Southwest
Wed, Oct 28 - Sun, Nov 29
Southwest Logo
1:50 pm - 9:55 pm
MHT
-
DSM
9h 05m
2 stops
Southwest Logo
5:20 am - 11:00 am
DSM
-
MHT
4h 40m
1 stop
$483Southwest
Wed, Oct 28 - Sun, Nov 29
American Airlines Logo
6:00 am - 12:34 pm
MHT
-
DSM
7h 34m
1 stop
American Airlines Logo
5:40 am - 2:17 pm
DSM
-
MHT
7h 37m
1 stop
$517American Airlines
Fri, Aug 14 - Mon, Aug 17
American Airlines Logo
5:12 pm - 11:44 pm
MHT
-
DSM
7h 32m
1 stop
American Airlines Logo
5:40 am - 2:17 pm
DSM
-
MHT
7h 37m
1 stop
$517American Airlines
Thu, Aug 13 - Mon, Aug 17

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American Airlines flights from Manchester, New Hampshire to Des Moines

Our best American Airlines deals on Manchester, New Hampshire to Des Moines flight tickets
American Airlines
Aug 20
MHT8:15 amManchester
5h 19m
1 stop
DSM12:34 pmDes Moines
Aug 23
DSM5:40 amDes Moines
7h 37m
1 stop
MHT2:17 pmManchester
$398
American Airlines
Aug 14
MHT5:12 pmManchester
7h 32m
1 stop
DSM11:44 pmDes Moines
Aug 17
DSM1:09 pmDes Moines
7h 56m
1 stop
MHT10:05 pmManchester
$428
American Airlines
Aug 20
MHT5:41 pmManchester
7h 39m
1 stop
DSM12:20 amDes Moines
Aug 24
DSM1:09 pmDes Moines
7h 56m
1 stop
MHT10:05 pmManchester
$440

United Airlines flights from Manchester, New Hampshire to Des Moines

Our best United Airlines deals on Manchester, New Hampshire to Des Moines flight tickets
United Airlines
Sep 1
MHT9:25 amManchester
8h 53m
2 stops
DSM5:18 pmDes Moines
Sep 5
DSM5:45 amDes Moines
12h 15m
2 stops
MHT7:00 pmManchester
$439
United Airlines
Aug 20
MHT2:46 pmManchester
9h 58m
2 stops
DSM11:44 pmDes Moines
Aug 23
DSM1:21 pmDes Moines
9h 38m
2 stops
MHT11:59 pmManchester
$474
United Airlines
Aug 20
MHT2:46 pmManchester
9h 58m
2 stops
DSM11:44 pmDes Moines
Aug 23
DSM1:21 pmDes Moines
9h 38m
3 stops
MHT11:59 pmManchester
$600

momondo Fare Finder

 
Customize your flight search to find flights from Manchester, New Hampshire to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 31, 2026.
Use the filters below to find and compare flights from Manchester, New Hampshire to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Thu 8/20

8:15 am-12:34 pm

1 stop5h 19m

Des Moines

Sun 8/23

5:40 am-2:17 pm

1 stop7h 37m

$398

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Fri 8/14

5:12 pm-11:44 pm

1 stop7h 32m

Des Moines

Mon 8/17

1:09 pm-10:05 pm

1 stop7h 56m

$428

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Tue 9/1

9:25 am-5:18 pm

2 stops8h 53m

Des Moines

Sat 9/5

5:45 am-7:00 pm

2 stops12h 15m

$439

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Sat 8/29

9:25 am-5:28 pm

2 stops9h 03m

Des Moines

Sat 9/5

6:00 am-7:00 pm

2 stops12h 00m

$439

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Thu 8/20

5:41 pm-12:20 am

1 stop7h 39m

Des Moines

Sun 8/23

6:10 am-4:38 pm

2 stops9h 28m

$443

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Thu 8/20

2:46 pm-11:44 pm

2 stops9h 58m

Des Moines

Sun 8/23

1:21 pm-11:59 pm

2 stops9h 38m

$474
Quickest round-trip

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Wed 10/28

5:50 pm-9:55 pm

1 stop5h 05m

Des Moines

Sun 11/29

5:20 am-11:00 am

1 stop4h 40m

$478

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Wed 10/28

1:50 pm-9:55 pm

2 stops9h 05m

Des Moines

Sun 11/29

5:20 am-11:00 am

1 stop4h 40m

$483

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Fri 8/14

6:00 am-12:34 pm

1 stop7h 34m

Des Moines

Mon 8/17

5:40 am-2:17 pm

1 stop7h 37m

$517

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Thu 8/13

5:12 pm-11:44 pm

1 stop7h 32m

Des Moines

Mon 8/17

5:40 am-2:17 pm

1 stop7h 37m

$517

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Manchester, New Hampshire to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Manchester, New Hampshire to Des Moines is on a Friday. Travelers who choose to depart for Des Moines on a Friday will often find tickets for as low as $126. Flights from Manchester, New Hampshire to Des Moines on a Sunday will generally be more expensive and average around $339. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

Can stopping save me money on Manchester, New Hampshire to Des Moines flights?

You could potentially save up to 45% on your flight if you consider stops on a Manchester, New Hampshire to Des Moines flight.

When to book flights from Manchester, New Hampshire to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Manchester, New Hampshire to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Manchester, New Hampshire to Des Moines (MHT to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Manchester, New Hampshire to Des Moines

Fastest flight time

4h 45m

Direct flights

None
The fastest flight from Manchester, New Hampshire to Des Moines takes 4h 45m
There are no direct flights from Manchester, New Hampshire to Des Moines. There are no popular flight routes from Manchester, New Hampshire to Des Moines.
Search flight deals

Frequently asked questions about flying from Manchester, New Hampshire to Des Moines

  • How far is Manchester to Des Moines by plane?

    A flight from Manchester to Des Moines will travel around 1133.4 mi. Typically, this will take 4h 45m by plane in normal conditions.

  • When did momondo last update prices for flights from Manchester Airport to Des Moines Airport?

    Prices for flights from Manchester Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from Manchester Airport to Des Moines Airport?

  • How old do you have to be to fly from Manchester Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Manchester Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Manchester, New Hampshire to Des Moines?

Best airlines flying from Manchester, New Hampshire to Des Moines

Compare and see reviews for airlines that fly from Manchester, New Hampshire to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $379Free CancellationRating
7.1
11,851 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Clive
Altoona
Pella
Urbandale
Johnston
Osceola
Newton
Boone
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Manchester to Des Moines?

It is quick and easy to find Manchester to Des Moines flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Des Moines that suits you.

Can I find flights from Manchester to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from Manchester on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Manchester to Des Moines?

momondo provides multiple filters to help you find the best flight to Des Moines from Manchester. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Manchester to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Manchester are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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