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Cheap flights from Manchester, New Hampshire to Des Moines from $299

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Manchester, New Hampshire to Des Moines departing on 1/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Manchester, New Hampshire to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:32 am - 12:46 pmMHT-DSM
8h 14m1 stop
American Airlines Logo
6:00 am - 11:34 amDSM-MHT
4h 34m1 stop
$299American Airlines
Find Deal
Sat, Jan 10 - Sat, Jan 17
American Airlines Logo
7:07 am - 11:25 amMHT-DSM
5h 18m1 stop
American Airlines Logo
2:16 pm - 10:52 pmDSM-MHT
7h 36m1 stop
$332American Airlines
Find Deal
Sat, Nov 1 - Thu, Nov 6
Southwest Logo
8:45 am - 2:55 pmMHT-DSM
7h 10m2 stops
Southwest Logo
6:45 am - 10:10 pmDSM-MHT
14h 25m2 stops
$388Southwest
Find Deal
Sat, Jan 10 - Sat, Jan 17
American Airlines Logo
6:00 am - 12:38 pmMHT-DSM
7h 38m1 stop
American Airlines Logo
5:00 am - 11:56 amDSM-MHT
5h 56m1 stop
$397American Airlines
Find Deal
Sat, Oct 25 - Thu, Oct 30
American Airlines Logo
5:45 am - 12:21 pmMHT-DSM
7h 36m1 stop
American Airlines Logo
6:00 am - 2:30 pmDSM-MHT
7h 30m1 stop
$407American Airlines
Find Deal
Tue, Mar 3 - Wed, Mar 4
United Airlines Logo
2:33 pm - 11:43 pmMHT-DSM
10h 10m2 stops
United Airlines Logo
8:00 am - 6:53 pmDSM-MHT
9h 53m2 stops
$417United Airlines
Find Deal
Tue, Mar 3 - Wed, Mar 4
Southwest Logo
5:30 am - 8:50 pmMHT-DSM
16h 20m2 stops
Southwest Logo
6:15 pm - 8:00 amDSM-MHT
12h 45m2 stops
$463Southwest
Find Deal
Sat, Nov 1 - Thu, Nov 6
United Airlines Logo
9:40 am - 10:27 pmMHT-DSM
13h 47m3 stops
United Airlines Logo
1:05 pm - 11:44 pmDSM-MHT
9h 39m2 stops
$581United Airlines
Find Deal
Sat, Oct 25 - Thu, Oct 30
Southwest Logo
9:15 am - 12:05 amMHT-DSM
15h 50m2 stops
Southwest Logo
5:30 am - 5:15 pmDSM-MHT
10h 45m2 stops
$610Southwest
Find Deal
Fri, Dec 26 - Mon, Dec 29
United Airlines Logo
2:27 pm - 12:14 pmMHT-DSM
22h 47m2 stops
United Airlines Logo
1:05 pm - 11:44 pmDSM-MHT
9h 39m2 stops
$629United Airlines
Find Deal
Fri, Nov 7 - Mon, Nov 10

American Airlines flights from Manchester, New Hampshire to Des Moines

Our best American Airlines deals on Manchester, New Hampshire to Des Moines flight tickets
American Airlines
Jan 10
MHT5:32 amManchester
8h 14m
1 stop
DSM12:46 pmDes Moines
Jan 17
DSM6:00 amDes Moines
4h 34m
1 stop
MHT11:34 amManchester
$299
Find similar
American Airlines
Nov 1
MHT7:07 amManchester
5h 18m
1 stop
DSM11:25 amDes Moines
Nov 6
DSM2:16 pmDes Moines
7h 36m
1 stop
MHT10:52 pmManchester
$332
Find similar
American Airlines
Oct 25
MHT6:00 amManchester
7h 38m
1 stop
DSM12:38 pmDes Moines
Oct 30
DSM5:00 amDes Moines
5h 56m
1 stop
MHT11:56 amManchester
$397
Find similar

Southwest flights from Manchester, New Hampshire to Des Moines

Our best Southwest deals on Manchester, New Hampshire to Des Moines flight tickets
Southwest
Jan 10
MHT8:45 amManchester
7h 10m
2 stops
DSM2:55 pmDes Moines
Jan 17
DSM6:45 amDes Moines
14h 25m
2 stops
MHT10:10 pmManchester
$388
Find similar
Southwest
Nov 1
MHT5:30 amManchester
16h 20m
2 stops
DSM8:50 pmDes Moines
Nov 6
DSM6:15 pmDes Moines
12h 45m
2 stops
MHT8:00 amManchester
$463
Find similar
Southwest
Dec 26
MHT9:15 amManchester
15h 50m
2 stops
DSM12:05 amDes Moines
Dec 29
DSM5:30 amDes Moines
10h 45m
2 stops
MHT5:15 pmManchester
$610
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Manchester, New Hampshire to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 6, 2025.
Use the filters below to find and compare flights from Manchester, New Hampshire to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Sat 1/10

5:32 am-12:46 pm

1 stop8h 14m

Des Moines

Sat 1/17

6:00 am-11:34 am

1 stop4h 34m

$299

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Sat 11/1

7:07 am-11:25 am

1 stop5h 18m

Des Moines

Thu 11/6

2:16 pm-10:52 pm

1 stop7h 36m

$332

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Sat 1/10

8:45 am-2:55 pm

2 stops7h 10m

Des Moines

Sat 1/17

6:45 am-10:10 pm

2 stops14h 25m

$388

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Sat 10/25

6:00 am-12:38 pm

1 stop7h 38m

Des Moines

Thu 10/30

5:00 am-11:56 am

1 stop5h 56m

$397

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Tue 3/3

5:45 am-12:21 pm

1 stop7h 36m

Des Moines

Wed 3/4

6:00 am-2:30 pm

1 stop7h 30m

$407

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Tue 3/3

2:33 pm-11:43 pm

2 stops10h 10m

Des Moines

Wed 3/4

8:00 am-6:53 pm

2 stops9h 53m

$417

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Sat 11/1

5:30 am-8:50 pm

2 stops16h 20m

Des Moines

Thu 11/6

6:15 pm-8:00 am

2 stops12h 45m

$463

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Sat 10/25

9:40 am-10:27 pm

3 stops13h 47m

Des Moines

Thu 10/30

1:05 pm-11:44 pm

2 stops9h 39m

$581

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Fri 12/26

9:15 am-12:05 am

2 stops15h 50m

Des Moines

Mon 12/29

5:30 am-5:15 pm

2 stops10h 45m

$610

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Fri 11/7

2:27 pm-12:14 pm

2 stops22h 47m

Des Moines

Mon 11/10

1:05 pm-11:44 pm

2 stops9h 39m

$629

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Des Moines from

How to get the cheapest flight ticket from Manchester, New Hampshire to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in May, then October is your next best option. Flight prices from Manchester, New Hampshire to Des Moines during October average around $386.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Manchester, New Hampshire to Des Moines is on a Friday. Travelers who choose to depart for Des Moines on a Friday will often find tickets for as low as $157. Flights from Manchester, New Hampshire to Des Moines on a Wednesday will generally be more expensive and average around $252. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the morning. momondo users have found flights departing from Manchester, New Hampshire to Des Moines in the morning for as low as $165. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the afternoon because they tend to be around $466. Of course, these prices can vary depending on the time of year and what airport you fly to.

Can stopping save me money on Manchester, New Hampshire to Des Moines flights?

You could potentially save up to 53% on your flight if you consider stops on a Manchester, New Hampshire to Des Moines flight.

When to book flights from Manchester, New Hampshire to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Manchester, New Hampshire to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Manchester, New Hampshire to Des Moines (MHT to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Manchester, New Hampshire to Des Moines

Direct flights

None
There are no direct flights from Manchester, New Hampshire to Des Moines. There are no popular flight routes from Manchester, New Hampshire to Des Moines.
Search flight deals

  • How far is Manchester to Des Moines by plane?

    A flight from Manchester to Des Moines will travel around 1133.4 mi. Typically, this will take 5h 18m by plane in normal conditions.

  • When did momondo last update prices for flights from Manchester Airport to Des Moines Airport?

    Prices for flights from Manchester Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from Manchester Airport to Des Moines Airport?

  • How old do you have to be to fly from Manchester Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Manchester Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Manchester, New Hampshire to Des Moines?

Best airlines flying from Manchester, New Hampshire to Des Moines

Compare and see reviews for airlines that fly from Manchester, New Hampshire to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $316Free CancellationRating
7.2
11,041 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Newton
Johnston
Boone
Osceola
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Manchester to Des Moines?

It is quick and easy to find Manchester to Des Moines flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Des Moines that suits you.

Can I find flights from Manchester to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from Manchester on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Manchester to Des Moines?

momondo provides multiple filters to help you find the best flight to Des Moines from Manchester. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Manchester to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Manchester are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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