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Cheap flights from Manchester, New Hampshire to Des Moines from $214

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Manchester, New Hampshire to Des Moines departing on 7/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Manchester, New Hampshire to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
6:15 pm - 10:45 pm
MHT
-
DSM
5h 30m
1 stop
Southwest Logo
4:40 pm - 10:00 pm
DSM
-
MHT
4h 20m
1 stop
$399Southwest
Wed, Jul 1 - Mon, Jul 6
Southwest Logo
7:00 pm - 11:35 pm
MHT
-
DSM
5h 35m
1 stop
Southwest Logo
6:10 am - 11:50 am
DSM
-
MHT
4h 40m
1 stop
$427Southwest
Thu, Jul 30 - Tue, Aug 4
American Airlines Logo
6:18 pm - 12:01 am
MHT
-
DSM
6h 43m
1 stop
American Airlines Logo
1:35 pm - 11:37 pm
DSM
-
MHT
9h 02m
2 stops
$432American Airlines
Thu, Jul 30 - Tue, Aug 4
American Airlines Logo
12:01 pm - 6:03 pm
MHT
-
DSM
7h 02m
1 stop
American Airlines Logo
5:00 am - 11:31 am
DSM
-
MHT
5h 31m
1 stop
$437American Airlines
Fri, Jul 3 - Tue, Jul 7
American Airlines Logo
12:03 pm - 8:18 pm
MHT
-
DSM
9h 15m
2 stops
American Airlines Logo
8:53 am - 5:47 pm
DSM
-
MHT
7h 54m
1 stop
$442American Airlines
Fri, Jul 3 - Tue, Jul 7
American Airlines Logo
2:54 pm - 12:01 am
MHT
-
DSM
10h 07m
2 stops
American Airlines Logo
5:00 am - 2:29 pm
DSM
-
MHT
8h 29m
2 stops
$447American Airlines
Fri, Jul 3 - Tue, Jul 7
Southwest Logo
5:45 am - 3:05 pm
MHT
-
DSM
10h 20m
2 stops
Southwest Logo
4:40 pm - 12:10 am
DSM
-
MHT
6h 30m
2 stops
$457Southwest
Wed, Jul 15 - Fri, Jul 17
United Airlines Logo
2:46 pm - 11:44 pm
MHT
-
DSM
9h 58m
2 stops
United Airlines Logo
6:00 am - 7:00 pm
DSM
-
MHT
12h 00m
2 stops
$472United Airlines
Tue, Sep 1 - Wed, Sep 2
American Airlines Logo
6:18 pm - 12:01 am
MHT
-
DSM
6h 43m
1 stop
American Airlines Logo
5:00 am - 11:31 am
DSM
-
MHT
5h 31m
1 stop
$476American Airlines
Thu, Jul 23 - Thu, Jul 30
American Airlines Logo
7:00 am - 1:21 pm
MHT
-
DSM
7h 21m
1 stop
American Airlines Logo
3:22 pm - 11:51 pm
DSM
-
MHT
7h 29m
1 stop
$477American Airlines
Thu, Jun 25 - Tue, Jun 30

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Southwest flights from Manchester, New Hampshire to Des Moines

Our best Southwest deals on Manchester, New Hampshire to Des Moines flight tickets
Southwest
Jul 30
MHT7:00 pmManchester
5h 35m
1 stop
DSM11:35 pmDes Moines
Aug 4
DSM6:10 amDes Moines
4h 40m
1 stop
MHT11:50 amManchester
$427
Southwest
Jul 15
MHT5:45 amManchester
10h 20m
2 stops
DSM3:05 pmDes Moines
Jul 17
DSM4:40 pmDes Moines
6h 30m
2 stops
MHT12:10 amManchester
$457
Southwest
Jul 30
MHT1:30 pmManchester
11h 05m
2 stops
DSM11:35 pmDes Moines
Aug 4
DSM6:10 amDes Moines
10h 25m
2 stops
MHT5:35 pmManchester
$503

American Airlines flights from Manchester, New Hampshire to Des Moines

Our best American Airlines deals on Manchester, New Hampshire to Des Moines flight tickets
American Airlines
Jul 30
MHT6:18 pmManchester
6h 43m
1 stop
DSM12:01 amDes Moines
Aug 4
DSM1:35 pmDes Moines
9h 02m
2 stops
MHT11:37 pmManchester
$432
American Airlines
Jul 3
MHT12:01 pmManchester
7h 02m
1 stop
DSM6:03 pmDes Moines
Jul 7
DSM5:00 amDes Moines
5h 31m
1 stop
MHT11:31 amManchester
$437
American Airlines
Jul 3
MHT12:03 pmManchester
9h 15m
2 stops
DSM8:18 pmDes Moines
Jul 7
DSM8:53 amDes Moines
7h 54m
1 stop
MHT5:47 pmManchester
$442

momondo Fare Finder

 
Customize your flight search to find flights from Manchester, New Hampshire to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 9, 2026.
Use the filters below to find and compare flights from Manchester, New Hampshire to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Wed 7/1

6:15 pm-10:45 pm

1 stop5h 30m

Des Moines

Mon 7/6

4:40 pm-10:00 pm

1 stop4h 20m

$399

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Thu 7/30

7:00 pm-11:35 pm

1 stop5h 35m

Des Moines

Tue 8/4

6:10 am-11:50 am

1 stop4h 40m

$427

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Thu 7/30

6:18 pm-12:01 am

1 stop6h 43m

Des Moines

Tue 8/4

1:35 pm-11:37 pm

2 stops9h 02m

$432

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Fri 7/3

12:01 pm-6:03 pm

1 stop7h 02m

Des Moines

Tue 7/7

5:00 am-11:31 am

1 stop5h 31m

$437

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Fri 7/3

12:03 pm-8:18 pm

2 stops9h 15m

Des Moines

Tue 7/7

8:53 am-5:47 pm

1 stop7h 54m

$442

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Fri 7/3

2:54 pm-12:01 am

2 stops10h 07m

Des Moines

Tue 7/7

5:00 am-2:29 pm

2 stops8h 29m

$447

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Wed 7/15

5:45 am-3:05 pm

2 stops10h 20m

Des Moines

Fri 7/17

4:40 pm-12:10 am

2 stops6h 30m

$457

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Tue 9/1

2:46 pm-11:44 pm

2 stops9h 58m

Des Moines

Wed 9/2

6:00 am-7:00 pm

2 stops12h 00m

$472

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Thu 7/23

6:18 pm-12:01 am

1 stop6h 43m

Des Moines

Thu 7/30

5:00 am-11:31 am

1 stop5h 31m

$476

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Thu 6/25

7:00 am-1:21 pm

1 stop7h 21m

Des Moines

Tue 6/30

3:22 pm-11:51 pm

1 stop7h 29m

$477

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Manchester, New Hampshire to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Manchester, New Hampshire to Des Moines is on a Saturday. Travelers who choose to depart for Des Moines on a Saturday will often find tickets for as low as $148. Flights from Manchester, New Hampshire to Des Moines on a Sunday will generally be more expensive and average around $298. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

Can stopping save me money on Manchester, New Hampshire to Des Moines flights?

You could potentially save up to 29% on your flight if you consider stops on a Manchester, New Hampshire to Des Moines flight.

When to book flights from Manchester, New Hampshire to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Manchester, New Hampshire to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Manchester, New Hampshire to Des Moines (MHT to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Manchester, New Hampshire to Des Moines

Fastest flight time

5h 35m

Direct flights

None
The fastest flight from Manchester, New Hampshire to Des Moines takes 5h 35m
There are no direct flights from Manchester, New Hampshire to Des Moines. There are no popular flight routes from Manchester, New Hampshire to Des Moines.
Search flight deals

Frequently asked questions about flying from Manchester, New Hampshire to Des Moines

  • How far is Manchester to Des Moines by plane?

    A flight from Manchester to Des Moines will travel around 1133.4 mi. Typically, this will take 5h 35m by plane in normal conditions.

  • When did momondo last update prices for flights from Manchester Airport to Des Moines Airport?

    Prices for flights from Manchester Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from Manchester Airport to Des Moines Airport?

  • How old do you have to be to fly from Manchester Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Manchester Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Manchester, New Hampshire to Des Moines?

Best airlines flying from Manchester, New Hampshire to Des Moines

Compare and see reviews for airlines that fly from Manchester, New Hampshire to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $316Free CancellationRating
7.1
11,640 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Pella
Urbandale
Osceola
Johnston
Newton
Boone
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Manchester to Des Moines?

It is quick and easy to find Manchester to Des Moines flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Des Moines that suits you.

Can I find flights from Manchester to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from Manchester on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Manchester to Des Moines?

momondo provides multiple filters to help you find the best flight to Des Moines from Manchester. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Manchester to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Manchester are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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