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Cheap flights from Manchester, New Hampshire to Des Moines from $264

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Manchester, New Hampshire to Des Moines departing on 7/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Manchester, New Hampshire to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
7:10 am - 11:35 am
MHT
-
DSM
5h 25m
1 stop
Southwest Logo
6:10 am - 11:50 am
DSM
-
MHT
4h 40m
1 stop
$364Southwest
Sun, Sep 13 - Wed, Sep 16
Southwest Logo
6:10 pm - 10:35 pm
MHT
-
DSM
5h 25m
1 stop
Southwest Logo
6:10 am - 5:35 pm
DSM
-
MHT
10h 25m
2 stops
$369Southwest
Sun, Sep 13 - Wed, Sep 16
American Airlines Logo
7:30 pm - 12:05 am
MHT
-
DSM
5h 35m
1 stop
American Airlines Logo
6:00 am - 12:25 pm
DSM
-
MHT
5h 25m
1 stop
$427American Airlines
Tue, Sep 22 - Sat, Sep 26
United Airlines Logo
9:25 am - 8:17 pm
MHT
-
DSM
11h 52m
2 stops
United Airlines Logo
6:00 am - 7:03 pm
DSM
-
MHT
12h 03m
2 stops
$433United Airlines
Tue, Sep 1 - Wed, Sep 2
United Airlines Logo
9:25 am - 5:02 pm
MHT
-
DSM
8h 37m
2 stops
United Airlines Logo
11:30 am - 11:56 pm
DSM
-
MHT
11h 26m
2 stops
$437United Airlines
Tue, Sep 22 - Sat, Sep 26
Southwest Logo
7:10 am - 3:15 pm
MHT
-
DSM
9h 05m
2 stops
Southwest Logo
6:10 am - 5:35 pm
DSM
-
MHT
10h 25m
2 stops
$440Southwest
Sun, Sep 13 - Wed, Sep 16
Southwest Logo
7:00 pm - 11:30 pm
MHT
-
DSM
5h 30m
1 stop
Southwest Logo
5:20 am - 10:50 am
DSM
-
MHT
4h 30m
1 stop
$467Southwest
Mon, Jul 13 - Tue, Jul 21
United Airlines Logo
9:25 am - 8:17 pm
MHT
-
DSM
11h 52m
2 stops
United Airlines Logo
11:34 am - 11:56 pm
DSM
-
MHT
11h 22m
2 stops
$470United Airlines
Tue, Sep 1 - Wed, Sep 2
Southwest Logo
1:30 pm - 11:30 pm
MHT
-
DSM
11h 00m
2 stops
Southwest Logo
5:20 am - 10:50 am
DSM
-
MHT
4h 30m
1 stop
$472Southwest
Mon, Jul 13 - Tue, Jul 21
Southwest Logo
1:30 pm - 11:30 pm
MHT
-
DSM
11h 00m
2 stops
Southwest Logo
7:00 pm - 8:30 am
DSM
-
MHT
12h 30m
2 stops
$477Southwest
Mon, Jul 13 - Tue, Jul 21

United Airlines flights from Manchester, New Hampshire to Des Moines

Our best United Airlines deals on Manchester, New Hampshire to Des Moines flight tickets
United Airlines
Sep 1
MHT9:25 amManchester
11h 52m
2 stops
DSM8:17 pmDes Moines
Sep 2
DSM6:00 amDes Moines
12h 03m
2 stops
MHT7:03 pmManchester
$433
United Airlines
Sep 22
MHT9:25 amManchester
8h 37m
2 stops
DSM5:02 pmDes Moines
Sep 26
DSM11:30 amDes Moines
11h 26m
2 stops
MHT11:56 pmManchester
$437
United Airlines
Sep 1
MHT9:25 amManchester
11h 52m
2 stops
DSM8:17 pmDes Moines
Sep 2
DSM11:34 amDes Moines
11h 22m
2 stops
MHT11:56 pmManchester
$470

American Airlines flights from Manchester, New Hampshire to Des Moines

Our best American Airlines deals on Manchester, New Hampshire to Des Moines flight tickets
American Airlines
May 23
MHT12:22 pmManchester
8h 10m
1 stop
DSM7:32 pmDes Moines
May 26
DSM1:37 pmDes Moines
8h 19m
1 stop
MHT10:56 pmManchester
$405
American Airlines
May 22
MHT5:32 pmManchester
7h 18m
1 stop
DSM11:50 pmDes Moines
May 26
DSM5:00 amDes Moines
5h 50m
1 stop
MHT11:50 amManchester
$426
American Airlines
Sep 22
MHT7:30 pmManchester
5h 35m
1 stop
DSM12:05 amDes Moines
Sep 26
DSM6:00 amDes Moines
5h 25m
1 stop
MHT12:25 pmManchester
$427

momondo Fare Finder

 
Customize your flight search to find flights from Manchester, New Hampshire to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 24, 2026.
Use the filters below to find and compare flights from Manchester, New Hampshire to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Sun 9/13

7:10 am-11:35 am

1 stop5h 25m

Des Moines

Wed 9/16

6:10 am-11:50 am

1 stop4h 40m

$364

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Sun 9/13

6:10 pm-10:35 pm

1 stop5h 25m

Des Moines

Wed 9/16

6:10 am-5:35 pm

2 stops10h 25m

$369

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Tue 9/22

7:30 pm-12:05 am

1 stop5h 35m

Des Moines

Sat 9/26

6:00 am-12:25 pm

1 stop5h 25m

$427

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Tue 9/1

9:25 am-8:17 pm

2 stops11h 52m

Des Moines

Wed 9/2

6:00 am-7:03 pm

2 stops12h 03m

$433

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Tue 9/22

9:25 am-5:02 pm

2 stops8h 37m

Des Moines

Sat 9/26

11:30 am-11:56 pm

2 stops11h 26m

$437

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Sun 9/13

7:10 am-3:15 pm

2 stops9h 05m

Des Moines

Wed 9/16

6:10 am-5:35 pm

2 stops10h 25m

$440
Quickest round-trip

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Mon 7/13

7:00 pm-11:30 pm

1 stop5h 30m

Des Moines

Tue 7/21

5:20 am-10:50 am

1 stop4h 30m

$467

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Tue 9/1

9:25 am-8:17 pm

2 stops11h 52m

Des Moines

Wed 9/2

11:34 am-11:56 pm

2 stops11h 22m

$470

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Mon 7/13

1:30 pm-11:30 pm

2 stops11h 00m

Des Moines

Tue 7/21

5:20 am-10:50 am

1 stop4h 30m

$472

ManchesterDes Moines

MHT - DSM

MHTDSM

Manchester

Mon 7/13

1:30 pm-11:30 pm

2 stops11h 00m

Des Moines

Tue 7/21

7:00 pm-8:30 am

2 stops12h 30m

$477

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Manchester, New Hampshire to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Manchester, New Hampshire to Des Moines is on a Thursday. Travelers who choose to depart for Des Moines on a Thursday will often find tickets for as low as $126. Flights from Manchester, New Hampshire to Des Moines on a Wednesday will generally be more expensive and average around $256. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

Can stopping save me money on Manchester, New Hampshire to Des Moines flights?

You could potentially save up to 29% on your flight if you consider stops on a Manchester, New Hampshire to Des Moines flight.

When to book flights from Manchester, New Hampshire to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Manchester, New Hampshire to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Manchester, New Hampshire to Des Moines (MHT to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Manchester, New Hampshire to Des Moines

Fastest flight time

4h 50m

Direct flights

None
The fastest flight from Manchester, New Hampshire to Des Moines takes 4h 50m
There are no direct flights from Manchester, New Hampshire to Des Moines. There are no popular flight routes from Manchester, New Hampshire to Des Moines.
Search flight deals

Frequently asked questions about flying from Manchester, New Hampshire to Des Moines

  • How far is Manchester to Des Moines by plane?

    A flight from Manchester to Des Moines will travel around 1133.4 mi. Typically, this will take 4h 50m by plane in normal conditions.

  • When did momondo last update prices for flights from Manchester Airport to Des Moines Airport?

    Prices for flights from Manchester Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from Manchester Airport to Des Moines Airport?

  • How old do you have to be to fly from Manchester Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Manchester Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Manchester, New Hampshire to Des Moines?

Best airlines flying from Manchester, New Hampshire to Des Moines

Compare and see reviews for airlines that fly from Manchester, New Hampshire to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $316Free CancellationRating
7.1
11,667 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Manchester to Des Moines?

It is quick and easy to find Manchester to Des Moines flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Des Moines that suits you.

Can I find flights from Manchester to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from Manchester on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Manchester to Des Moines?

momondo provides multiple filters to help you find the best flight to Des Moines from Manchester. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Manchester to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Manchester are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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