Latest deals
Insights
When to book
FAQs
Price Alerts

Cheap flights from Louisville to Florence from $581

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Louisville to Florence departing on 4/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Louisville to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:00 pm - 10:42 pm
SDF
-
FLO
5h 42m
1 stop
American Airlines Logo
5:20 am - 8:38 am
FLO
-
SDF
3h 18m
1 stop
$581American Airlines
Tue, Apr 28 - Wed, May 6
American Airlines Logo
4:12 pm - 9:47 pm
SDF
-
FLO
5h 35m
1 stop
American Airlines Logo
6:15 am - 9:55 am
FLO
-
SDF
3h 40m
1 stop
$585American Airlines
Thu, Apr 30 - Tue, May 5
American Airlines Logo
6:00 am - 3:32 pm
SDF
-
FLO
9h 32m
2 stops
American Airlines Logo
5:20 am - 8:38 am
FLO
-
SDF
3h 18m
1 stop
$586American Airlines
Tue, Apr 28 - Wed, May 6
American Airlines Logo
11:20 am - 3:50 pm
SDF
-
FLO
4h 30m
1 stop
American Airlines Logo
6:15 am - 4:05 pm
FLO
-
SDF
9h 50m
2 stops
$590American Airlines
Thu, Apr 30 - Tue, May 5
American Airlines Logo
12:11 pm - 10:42 pm
SDF
-
FLO
10h 31m
2 stops
American Airlines Logo
4:02 pm - 11:48 pm
FLO
-
SDF
7h 46m
2 stops
$592American Airlines
Tue, Apr 28 - Tue, May 5
American Airlines Logo
11:16 am - 9:47 pm
SDF
-
FLO
10h 31m
2 stops
American Airlines Logo
4:02 pm - 11:48 pm
FLO
-
SDF
7h 46m
2 stops
$596American Airlines
Thu, Apr 30 - Tue, May 5
American Airlines Logo
9:43 am - 3:50 pm
SDF
-
FLO
6h 07m
1 stop
American Airlines Logo
6:15 am - 9:55 am
FLO
-
SDF
3h 40m
1 stop
$611American Airlines
Sat, Apr 25 - Tue, Apr 28
American Airlines Logo
4:30 pm - 9:47 pm
SDF
-
FLO
5h 17m
1 stop
American Airlines Logo
5:20 am - 10:30 am
FLO
-
SDF
5h 10m
1 stop
$615American Airlines
Sat, Apr 25 - Fri, May 1
American Airlines Logo
6:07 am - 3:50 pm
SDF
-
FLO
9h 43m
2 stops
American Airlines Logo
4:02 pm - 9:20 pm
FLO
-
SDF
5h 18m
1 stop
$616American Airlines
Sat, Apr 25 - Tue, Apr 28
American Airlines Logo
9:43 am - 3:50 pm
SDF
-
FLO
6h 07m
1 stop
American Airlines Logo
5:20 am - 8:38 am
FLO
-
SDF
3h 18m
1 stop
$619American Airlines
Fri, Apr 24 - Thu, Apr 30

American Airlines flights from Louisville to Florence, South Carolina

Our best American Airlines deals on Louisville to Florence, South Carolina flight tickets
American Airlines
Apr 28
SDF5:00 pmLouisville Intl
5h 42m
1 stop
FLO10:42 pmFlorence
May 5
FLO6:15 amFlorence
3h 40m
1 stop
SDF9:55 amLouisville Intl
$581
American Airlines
Apr 30
SDF4:12 pmLouisville Intl
5h 35m
1 stop
FLO9:47 pmFlorence
May 5
FLO6:15 amFlorence
3h 40m
1 stop
SDF9:55 amLouisville Intl
$585
American Airlines
Apr 28
SDF6:00 amLouisville Intl
9h 32m
2 stops
FLO3:32 pmFlorence
May 6
FLO5:20 amFlorence
3h 18m
1 stop
SDF8:38 amLouisville Intl
$586

momondo Fare Finder

 
Customize your flight search to find flights from Louisville to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 8, 2026.
Use the filters below to find and compare flights from Louisville to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

LouisvilleFlorence

SDF - FLO

SDFFLO

Louisville Intl

Tue 4/28

5:00 pm-10:42 pm

1 stop5h 42m

Florence

Wed 5/6

5:20 am-8:38 am

1 stop3h 18m

$581

LouisvilleFlorence

SDF - FLO

SDFFLO

Louisville Intl

Thu 4/30

4:12 pm-9:47 pm

1 stop5h 35m

Florence

Tue 5/5

6:15 am-9:55 am

1 stop3h 40m

$585

LouisvilleFlorence

SDF - FLO

SDFFLO

Louisville Intl

Tue 4/28

6:00 am-3:32 pm

2 stops9h 32m

Florence

Wed 5/6

5:20 am-8:38 am

1 stop3h 18m

$586

LouisvilleFlorence

SDF - FLO

SDFFLO

Louisville Intl

Thu 4/30

11:20 am-3:50 pm

1 stop4h 30m

Florence

Tue 5/5

6:15 am-4:05 pm

2 stops9h 50m

$590

LouisvilleFlorence

SDF - FLO

SDFFLO

Louisville Intl

Tue 4/28

12:11 pm-10:42 pm

2 stops10h 31m

Florence

Tue 5/5

4:02 pm-11:48 pm

2 stops7h 46m

$592

LouisvilleFlorence

SDF - FLO

SDFFLO

Louisville Intl

Thu 4/30

11:16 am-9:47 pm

2 stops10h 31m

Florence

Tue 5/5

4:02 pm-11:48 pm

2 stops7h 46m

$596

LouisvilleFlorence

SDF - FLO

SDFFLO

Louisville Intl

Sat 4/25

9:43 am-3:50 pm

1 stop6h 07m

Florence

Tue 4/28

6:15 am-9:55 am

1 stop3h 40m

$611

LouisvilleFlorence

SDF - FLO

SDFFLO

Louisville Intl

Sat 4/25

4:30 pm-9:47 pm

1 stop5h 17m

Florence

Fri 5/1

5:20 am-10:30 am

1 stop5h 10m

$615

LouisvilleFlorence

SDF - FLO

SDFFLO

Louisville Intl

Sat 4/25

6:07 am-3:50 pm

2 stops9h 43m

Florence

Tue 4/28

4:02 pm-9:20 pm

1 stop5h 18m

$616

LouisvilleFlorence

SDF - FLO

SDFFLO

Louisville Intl

Fri 4/24

9:43 am-3:50 pm

1 stop6h 07m

Florence

Thu 4/30

5:20 am-8:38 am

1 stop3h 18m

$619

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Louisville to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Florence, South Carolina?

American Airlines, Allegiant Air and Delta are the top three most popular airlines that fly to Florence, South Carolina from Louisville according to our data. American Airlines is the first choice among our users, with 40% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 9 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Louisville to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Louisville to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Louisville to Florence, South Carolina (SDF to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Louisville to Florence, South Carolina

Fastest flight time

5h 17m

Direct flights

None
The fastest flight from Louisville to Florence, South Carolina takes 5h 17m
There are no direct flights from Louisville to Florence, South Carolina. There are no popular flight routes from Louisville to Florence, South Carolina.
Search flight deals

Frequently asked questions about flying from Louisville to Florence, South Carolina

  • How far is Louisville Intl to Florence by plane?

    There are 435.4 mi between Louisville Intl and Florence. A reasonable flight in good conditions will take 5h 17m.

  • When did momondo last update prices for flights from Louisville Intl Airport to Florence Airport?

    Prices for flights from Louisville Intl Airport to Florence Airport are updated daily.

  • How old do you have to be to fly from Louisville Intl Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Louisville Intl Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents required for your trip to Florence Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Florence Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Lake City
Darlington
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Louisville to Florence?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Louisville to Florence. momondo saves you time and could save you money on your trip.

Can I find flights from Louisville to Florence with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Florence from Louisville with this policy.

How can momondo help me find flights from Louisville to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Louisville to Florence.

I’m not ready to book a flight from Louisville to Florence right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Louisville to Florence now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Florence and let you know when they change.

An easier way to manage your Florence, South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Fri 5/8
Fri 5/15
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States