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Cheap flights from Louisville to Florence from $437

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Louisville to Florence departing on 2/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Louisville to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:00 am - 5:50 pm
SDF
-
FLO
11h 50m
2 stops
American Airlines Logo
5:58 pm - 10:42 am
FLO
-
SDF
16h 44m
2 stops
$437American Airlines
Sat, Feb 28 - Wed, Mar 4
American Airlines Logo
8:00 pm - 11:57 pm
SDF
-
FLO
3h 57m
1 stop
American Airlines Logo
6:15 am - 9:51 am
FLO
-
SDF
3h 36m
1 stop
$501American Airlines
Sat, Feb 28 - Wed, Mar 4
American Airlines Logo
2:04 pm - 11:57 pm
SDF
-
FLO
9h 53m
2 stops
American Airlines Logo
5:58 pm - 11:05 pm
FLO
-
SDF
5h 07m
1 stop
$506American Airlines
Sat, Feb 28 - Wed, Mar 4
American Airlines Logo
8:02 pm - 11:57 pm
SDF
-
FLO
3h 55m
1 stop
American Airlines Logo
5:16 am - 9:02 am
FLO
-
SDF
3h 46m
1 stop
$702American Airlines
Thu, Feb 26 - Mon, Mar 2
American Airlines Logo
8:02 pm - 11:57 pm
SDF
-
FLO
3h 55m
1 stop
American Airlines Logo
5:16 am - 3:03 pm
FLO
-
SDF
9h 47m
2 stops
$707American Airlines
Thu, Feb 26 - Mon, Mar 2
American Airlines Logo
11:12 am - 5:50 pm
SDF
-
FLO
6h 38m
2 stops
American Airlines Logo
5:16 am - 3:03 pm
FLO
-
SDF
9h 47m
2 stops
$746American Airlines
Thu, Feb 26 - Mon, Mar 2

American Airlines flights from Louisville to Florence, South Carolina

Our best American Airlines deals on Louisville to Florence, South Carolina flight tickets
American Airlines
Feb 28
SDF6:00 amLouisville Intl
11h 50m
2 stops
FLO5:50 pmFlorence
Mar 4
FLO5:58 pmFlorence
16h 44m
2 stops
SDF10:42 amLouisville Intl
$437
American Airlines
Feb 28
SDF8:00 pmLouisville Intl
3h 57m
1 stop
FLO11:57 pmFlorence
Mar 4
FLO6:15 amFlorence
3h 36m
1 stop
SDF9:51 amLouisville Intl
$501
American Airlines
Feb 28
SDF2:04 pmLouisville Intl
9h 53m
2 stops
FLO11:57 pmFlorence
Mar 4
FLO5:58 pmFlorence
5h 07m
1 stop
SDF11:05 pmLouisville Intl
$506

momondo Fare Finder

 
Customize your flight search to find flights from Louisville to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 14, 2026.
Use the filters below to find and compare flights from Louisville to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

LouisvilleFlorence

SDF - FLO

SDFFLO

Louisville Intl

Sat 2/28

6:00 am-5:50 pm

2 stops11h 50m

Florence

Wed 3/4

5:58 pm-10:42 am

2 stops16h 44m

$437

LouisvilleFlorence

SDF - FLO

SDFFLO

Louisville Intl

Sat 2/28

8:00 pm-11:57 pm

1 stop3h 57m

Florence

Wed 3/4

6:15 am-9:51 am

1 stop3h 36m

$501

LouisvilleFlorence

SDF - FLO

SDFFLO

Louisville Intl

Sat 2/28

2:04 pm-11:57 pm

2 stops9h 53m

Florence

Wed 3/4

5:58 pm-11:05 pm

1 stop5h 07m

$506

LouisvilleFlorence

SDF - FLO

SDFFLO

Louisville Intl

Thu 2/26

8:02 pm-11:57 pm

1 stop3h 55m

Florence

Mon 3/2

5:16 am-9:02 am

1 stop3h 46m

$702

LouisvilleFlorence

SDF - FLO

SDFFLO

Louisville Intl

Thu 2/26

8:02 pm-11:57 pm

1 stop3h 55m

Florence

Mon 3/2

5:16 am-3:03 pm

2 stops9h 47m

$707

LouisvilleFlorence

SDF - FLO

SDFFLO

Louisville Intl

Thu 2/26

11:12 am-5:50 pm

2 stops6h 38m

Florence

Mon 3/2

5:16 am-3:03 pm

2 stops9h 47m

$746

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Louisville to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Florence, South Carolina?

American Airlines, Allegiant Air and Delta are the top three most popular airlines that fly to Florence, South Carolina from Louisville according to our data. American Airlines is the first choice among our users, with 42% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 8 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Louisville to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Louisville to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Louisville to Florence, South Carolina (SDF to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Louisville to Florence, South Carolina

Fastest flight time

3h 55m

Direct flights

None
The fastest flight from Louisville to Florence, South Carolina takes 3h 55m
There are no direct flights from Louisville to Florence, South Carolina. There are no popular flight routes from Louisville to Florence, South Carolina.
Search flight deals

  • How far is Louisville Intl to Florence by plane?

    There are 435.4 mi between Louisville Intl and Florence. A reasonable flight in good conditions will take 3h 55m.

  • When did momondo last update prices for flights from Louisville Intl Airport to Florence Airport?

    Prices for flights from Louisville Intl Airport to Florence Airport are updated daily.

  • How old do you have to be to fly from Louisville Intl Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Louisville Intl Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents required for your trip to Florence Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Florence Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Darlington
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Louisville to Florence?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Louisville to Florence. momondo saves you time and could save you money on your trip.

Can I find flights from Louisville to Florence with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Florence from Louisville with this policy.

How can momondo help me find flights from Louisville to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Louisville to Florence.

I’m not ready to book a flight from Louisville to Florence right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Louisville to Florence now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Florence and let you know when they change.

An easier way to manage your Florence, South Carolina trip

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