What airlines fly to Panama City, Florida?

Delta, Allegiant Air and Southwest are the top three most popular airlines that fly to Panama City, Florida from Knoxville according to our data. Delta is the first choice among our users, with 59% of people opting to fly with this airline when traveling to Panama City, Florida. Keep in mind that there are 4 different airlines that fly to Panama City, Florida on a routine basis, so you have a few additional options to choose from.

Which airport is the most popular layover for flights between Knoxville and Panama City, Florida?

Nashville (BNA) was the most common stop: 40% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport has the shortest travel time from Knoxville to Panama City, Florida?

Flights connecting via Atlanta (ATL) have the shortest average one-way travel time: 3h 29m.

What is the cheapest airline that flies from Knoxville McGhee Tyson to Panama City NW Florida Beaches?

Delta, Southwest, and American Airlines are the most popular carriers operating from Knoxville McGhee Tyson to Panama City NW Florida Beaches

Which layover airport offers the lowest fares from Knoxville to Panama City, Florida?

Flights via Charlotte (CLT) offer the lowest average round-trip price of $258.

Which layover airport has the shortest connection time from Knoxville to Panama City, Florida?

Charlotte (CLT) has the shortest average layover time for this route: 1h 13m.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport?

Prices for flights from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport were last updated today.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport?

The number of operators available for flights from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport is 3 as of November 2026.

How old do you have to be to fly from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport.

What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

The travel and health documents you'll need for your trip to Panama City NW Florida Beaches Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama City NW Florida Beaches Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$130 Cheap Flights from Knoxville to Panama City, Florida in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Panama City

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One-way

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Cheap round-trip flights

Enter your travel dates to find the best prices.

5:40 am - 8:44 amTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

4h 04m1 stop Atlanta Hartsfield-Jackson

1:38 pm - 7:34 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

4h 56m1 stop Atlanta Hartsfield-Jackson

$259Delta

Fri, Nov 27 - Fri, Dec 4

7:05 am - 9:35 amTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

3h 30m1 stop Nashville Intl

6:25 pm - 10:40 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

3h 15m1 stop Nashville Intl

$333Southwest

Thu, Dec 17 - Tue, Dec 22

6:05 pm - 11:47 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

6h 42m1 stop Charlotte Douglas

7:51 am - 3:26 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

6h 35m1 stop Charlotte Douglas

$343American Airlines

Mon, Nov 30 - Mon, Dec 7

7:20 pm - 9:19 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

2h 59m1 stop Atlanta Hartsfield-Jackson

7:05 pm - 11:46 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

3h 41m1 stop Atlanta Hartsfield-Jackson

$359Delta

Sun, Mar 14 - Sun, Mar 21

7:05 am - 9:35 amTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

3h 30m1 stop Nashville Intl

9:55 am - 10:40 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

11h 45m2 stops Austin Bergstrom Nashville Intl

$394Southwest

Thu, Dec 17 - Tue, Dec 22

6:50 am - 10:39 amTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

4h 49m1 stop Charlotte Douglas

11:04 am - 11:46 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

11h 42m2 stops Charlotte Douglas Chicago O'Hare Intl

$430American Airlines

Fri, Nov 27 - Fri, Dec 4

10:35 am - 3:06 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

5h 31m1 stop Atlanta Hartsfield-Jackson

7:10 am - 11:27 amECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

3h 17m1 stop Atlanta Hartsfield-Jackson

$447Delta

Sun, Nov 29 - Sun, Dec 6

12:50 pm - 8:35 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

8h 45m2 stops Orlando Nashville Intl

9:55 am - 10:40 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

11h 45m2 stops Austin Bergstrom Nashville Intl

$473Southwest

Thu, Dec 17 - Tue, Dec 22

11:43 am - 9:58 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

11h 15m1 stop Houston George Bush Intcntl

2:58 pm - 10:55 amECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

18h 57m1 stop Houston George Bush Intcntl

$775United Airlines

Mon, Dec 21 - Thu, Dec 24

11:43 am - 9:58 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

11h 15m1 stop Houston George Bush Intcntl

6:23 am - 6:49 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

11h 26m1 stop Houston George Bush Intcntl

$785United Airlines

Mon, Dec 21 - Thu, Dec 24

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United Airlines flights from Knoxville to Panama City, Florida

Our best United Airlines deals on Knoxville to Panama City, Florida flight tickets

United Airlines

Dec 21

TYS11:43 amKnoxville McGhee Tyson

11h 15m

1 stop

ECP9:58 pmPanama City NW Florida Beaches

Dec 24

ECP2:58 pmPanama City NW Florida Beaches

18h 57m

1 stop

TYS10:55 amKnoxville McGhee Tyson

$775

United Airlines

Dec 21

TYS11:43 amKnoxville McGhee Tyson

11h 15m

1 stop

ECP9:58 pmPanama City NW Florida Beaches

Dec 24

ECP6:23 amPanama City NW Florida Beaches

11h 26m

1 stop

TYS6:49 pmKnoxville McGhee Tyson

$785

United Airlines

Dec 21

TYS11:43 amKnoxville McGhee Tyson

11h 15m

1 stop

ECP9:58 pmPanama City NW Florida Beaches

Dec 24

ECP6:23 amPanama City NW Florida Beaches

31h 19m

2 stops

TYS2:42 pmKnoxville McGhee Tyson

$844

Southwest flights from Knoxville to Panama City, Florida

Our best Southwest deals on Knoxville to Panama City, Florida flight tickets

Southwest

Dec 17

TYS7:05 amKnoxville McGhee Tyson

3h 30m

1 stop

ECP9:35 amPanama City NW Florida Beaches

Dec 22

ECP6:25 pmPanama City NW Florida Beaches

3h 15m

1 stop

TYS10:40 pmKnoxville McGhee Tyson

$333

Southwest

Dec 17

TYS7:05 amKnoxville McGhee Tyson

3h 30m

1 stop

ECP9:35 amPanama City NW Florida Beaches

Dec 22

ECP9:55 amPanama City NW Florida Beaches

11h 45m

2 stops

TYS10:40 pmKnoxville McGhee Tyson

$394

Southwest

Dec 17

TYS12:50 pmKnoxville McGhee Tyson

8h 45m

2 stops

ECP8:35 pmPanama City NW Florida Beaches

Dec 22

ECP9:55 amPanama City NW Florida Beaches

11h 45m

2 stops

TYS10:40 pmKnoxville McGhee Tyson

$473

momondo Fare Finder

Use the filters below to find and compare flights from Knoxville to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvillePanama City

TYS Knoxville McGhee Tyson - ECP Panama City NW Florida Beaches

TYSECP

Knoxville McGhee Tyson

Fri 11/27

5:40 am-8:44 am

1 stop4h 04m

Panama City NW Florida Beaches

Fri 12/4

1:38 pm-7:34 pm

1 stop4h 56m

$259

KnoxvillePanama City

TYS Knoxville McGhee Tyson - ECP Panama City NW Florida Beaches

TYSECP

Knoxville McGhee Tyson

Thu 12/17

7:05 am-9:35 am

1 stop3h 30m

Panama City NW Florida Beaches

Tue 12/22

6:25 pm-10:40 pm

1 stop3h 15m

$333

KnoxvillePanama City

TYS Knoxville McGhee Tyson - ECP Panama City NW Florida Beaches

TYSECP

Knoxville McGhee Tyson

Mon 11/30

6:05 pm-11:47 pm

1 stop6h 42m

Panama City NW Florida Beaches

Mon 12/7

7:51 am-3:26 pm

1 stop6h 35m

$343

Quickest round-trip

KnoxvillePanama City

TYS Knoxville McGhee Tyson - ECP Panama City NW Florida Beaches

TYSECP

Knoxville McGhee Tyson

Sun 3/14

7:20 pm-9:19 pm

1 stop2h 59m

Panama City NW Florida Beaches

Sun 3/21

7:05 pm-11:46 pm

1 stop3h 41m

$359

KnoxvillePanama City

TYS Knoxville McGhee Tyson - ECP Panama City NW Florida Beaches

TYSECP

Knoxville McGhee Tyson

Thu 12/17

7:05 am-9:35 am

1 stop3h 30m

Panama City NW Florida Beaches

Tue 12/22

9:55 am-10:40 pm

2 stops11h 45m

$394

KnoxvillePanama City

TYS Knoxville McGhee Tyson - ECP Panama City NW Florida Beaches

TYSECP

Knoxville McGhee Tyson

Fri 11/27

6:50 am-10:39 am

1 stop4h 49m

Panama City NW Florida Beaches

Fri 12/4

11:04 am-11:46 pm

2 stops11h 42m

$430

KnoxvillePanama City

TYS Knoxville McGhee Tyson - ECP Panama City NW Florida Beaches

TYSECP

Knoxville McGhee Tyson

Sun 11/29

10:35 am-3:06 pm

1 stop5h 31m

Panama City NW Florida Beaches

Sun 12/6

7:10 am-11:27 am

1 stop3h 17m

$447

KnoxvillePanama City

TYS Knoxville McGhee Tyson - ECP Panama City NW Florida Beaches

TYSECP

Knoxville McGhee Tyson

Thu 12/17

12:50 pm-8:35 pm

2 stops8h 45m

Panama City NW Florida Beaches

Tue 12/22

9:55 am-10:40 pm

2 stops11h 45m

$473

KnoxvillePanama City

TYS Knoxville McGhee Tyson - ECP Panama City NW Florida Beaches

TYSECP

Knoxville McGhee Tyson

Mon 12/21

11:43 am-9:58 pm

1 stop11h 15m

Panama City NW Florida Beaches

Thu 12/24

2:58 pm-10:55 am

1 stop18h 57m

$775

KnoxvillePanama City

TYS Knoxville McGhee Tyson - ECP Panama City NW Florida Beaches

TYSECP

Knoxville McGhee Tyson

Mon 12/21

11:43 am-9:58 pm

1 stop11h 15m

Panama City NW Florida Beaches

Thu 12/24

6:23 am-6:49 pm

1 stop11h 26m

$785

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first

How to get the cheapest flight ticket from Knoxville to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the typical price of a round-trip flight between Knoxville and Panama City, Florida?

Prices are currently low for flights on this route.

Typical prices usually range from $287 to $346.
The lowest price recently found on this route was $259.

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from Knoxville is in November. Flight prices, which tend to average around $292, are often lower during this time because this is during the off-season. The month of May is another great option to travel to Panama City, Florida, with average flight prices from Knoxville averaging around $312.

When to book flights from Knoxville to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Knoxville to Panama City, Florida (TYS to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Panama City, Florida

Best Price Found	$130
Fastest flight time	2h 59m
Direct flights	None

The best one-way flight to Panama City, Florida from Knoxville in the past 72 hours is $130. The best round-trip flight deal from Knoxville to Panama City, Florida found on momondo in the last 72 hours is $259.

The fastest flight from Knoxville to Panama City, Florida takes 2h 59m

There are no direct flights from Knoxville to Panama City, Florida. There are no popular flight routes from Knoxville to Panama City, Florida.

Search flight deals

Frequently asked questions about flying from Knoxville to Panama City, Florida

How far is Knoxville McGhee Tyson to Panama City NW Florida Beaches by plane?
The distance between Knoxville McGhee Tyson and Panama City NW Florida Beaches is about 413.0 mi. In terms of flight time, this usually takes a little over 2h 59m.
When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport?
Prices for flights from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport were last updated today.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport?
The number of operators available for flights from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport is 3 as of November 2026.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport.
What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?
The travel and health documents you'll need for your trip to Panama City NW Florida Beaches Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama City NW Florida Beaches Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Knoxville to Panama City, Florida?
momondo data reveals that the most frequently booked airline on the route from Knoxville to Panama City, Florida is Delta, representing 48% of all bookings. The subsequent popular airlines are Southwest at 43% and American Airlines at 9%.

Best airlines flying from Knoxville to Panama City, Florida

Compare and see reviews for airlines that fly from Knoxville to Panama City, Florida with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $216	Free Cancellation	Rating 7.0 12,228 reviews	Search American Airlines flights
Southwest	PriceFrom $242	Free Cancellation	Rating 8.0 4,213 reviews	Search Southwest flights
Delta	PriceFrom $265	Free Cancellation	Rating 7.8 8,701 reviews	Search Delta flights

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Port St. Joe

Seaside

Mexico Beach

Seagrove Beach

Freeport

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Panama City?

Finding the right flight to Panama City from Knoxville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from Knoxville to Panama City with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama City from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Panama City?

momondo helps you find the best flight between Knoxville and Panama City by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Panama City right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Panama City now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama City and let you know when they change.

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Cheap flights from Knoxville to Panama City from $130

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Panama City departing on 11/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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United Airlines flights from Knoxville to Panama City, Florida

Our best United Airlines deals on Knoxville to Panama City, Florida flight tickets

Southwest flights from Knoxville to Panama City, Florida

Our best Southwest deals on Knoxville to Panama City, Florida flight tickets

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Use the filters below to find and compare flights from Knoxville to Panama City, Florida that are best for you.

See travel insights to Panama City from

How to get the cheapest flight ticket from Knoxville to Panama City, Florida

What is the typical price of a round-trip flight between Knoxville and Panama City, Florida?

What is the cheapest month to fly to Panama City, Florida?

What is the cheapest airline that flies from Knoxville McGhee Tyson to Panama City NW Florida Beaches?

What airlines fly to Panama City, Florida?

Which airport is the most popular layover for flights between Knoxville and Panama City, Florida?

Which layover airport offers the lowest fares from Knoxville to Panama City, Florida?

Which layover airport has the shortest travel time from Knoxville to Panama City, Florida?

Which layover airport has the shortest connection time from Knoxville to Panama City, Florida?

When to book flights from Knoxville to Panama City, Florida

Cheap Knoxville to Panama City, Florida (TYS to ECP) flight deals and tips

Best Price Found

Fastest flight time

Direct flights

Frequently asked questions about flying from Knoxville to Panama City, Florida

Best airlines flying from Knoxville to Panama City, Florida

Compare and see reviews for airlines that fly from Knoxville to Panama City, Florida with momondo

Traveling to a place near Panama City?

Why use momondo?

An easier way to manage your Panama City, Florida trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to the United States

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List of cabin classes available on flights landing in Panama City. Availability may vary depending on flight origin and airline.

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