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Cheap flights from Knoxville to Panama City from $187

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Panama City departing on 12/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
3:50 pm - 7:00 pmTYS-ECP
4h 10m1 stop
Delta Logo
1:32 pm - 6:58 pmECP-TYS
4h 26m1 stop
$187Delta
Find Deal
Sat, Dec 6 - Tue, Dec 9
American Airlines Logo
5:51 pm - 12:04 amTYS-ECP
7h 13m1 stop
American Airlines Logo
12:08 pm - 11:57 pmECP-TYS
10h 49m2 stops
$252American Airlines
Find Deal
Sat, Dec 6 - Tue, Dec 9
Delta Logo
2:41 pm - 7:00 pmTYS-ECP
5h 19m1 stop
Delta Logo
1:32 pm - 7:02 pmECP-TYS
4h 30m1 stop
$327Delta
Find Deal
Tue, Nov 18 - Tue, Nov 25
Delta Logo
5:35 am - 8:35 amTYS-ECP
4h 00m1 stop
Delta Logo
7:23 am - 1:44 pmECP-TYS
5h 21m1 stop
$337Delta
Find Deal
Thu, Nov 20 - Thu, Nov 27
American Airlines Logo
6:00 am - 2:13 pmTYS-ECP
9h 13m2 stops
American Airlines Logo
12:08 pm - 11:57 pmECP-TYS
10h 49m2 stops
$362American Airlines
Find Deal
Sat, Dec 6 - Tue, Dec 9
American Airlines Logo
6:00 am - 2:13 pmTYS-ECP
9h 13m2 stops
American Airlines Logo
12:08 pm - 11:57 pmECP-TYS
10h 49m2 stops
$382American Airlines
Find Deal
Sat, Dec 6 - Tue, Dec 9
Southwest Logo
6:30 am - 2:05 pmTYS-ECP
8h 35m1 stop
Southwest Logo
6:40 am - 10:00 pmECP-TYS
14h 20m2 stops
$494Southwest
Find Deal
Fri, Mar 20 - Sun, Mar 22
Southwest Logo
6:30 am - 12:50 pmTYS-ECP
7h 20m2 stops
Southwest Logo
6:40 am - 10:00 pmECP-TYS
14h 20m2 stops
$542Southwest
Find Deal
Fri, Mar 20 - Sun, Mar 22
United Airlines Logo
7:00 am - 9:19 amTYS-ECP
27h 19m1 stop
United Airlines Logo
6:30 am - 10:30 pmECP-TYS
15h 00m2 stops
$656United Airlines
Find Deal
Sat, Nov 8 - Thu, Nov 13
United Airlines Logo
4:50 pm - 4:23 pmTYS-ECP
24h 33m2 stops
United Airlines Logo
10:04 am - 11:44 pmECP-TYS
12h 40m1 stop
$671United Airlines
Find Deal
Sat, Nov 8 - Thu, Nov 13

Southwest flights from Knoxville to Panama City, Florida

Our best Southwest deals on Knoxville to Panama City, Florida flight tickets
Southwest
Mar 20
TYS6:30 amKnoxville McGhee Tyson
8h 35m
1 stop
ECP2:05 pmPanama City NW Florida Beaches
Mar 22
ECP6:40 amPanama City NW Florida Beaches
14h 20m
2 stops
TYS10:00 pmKnoxville McGhee Tyson
$494
Find similar
Southwest
Mar 20
TYS6:30 amKnoxville McGhee Tyson
7h 20m
2 stops
ECP12:50 pmPanama City NW Florida Beaches
Mar 22
ECP6:40 amPanama City NW Florida Beaches
14h 20m
2 stops
TYS10:00 pmKnoxville McGhee Tyson
$542
Find similar

Delta flights from Knoxville to Panama City, Florida

Our best Delta deals on Knoxville to Panama City, Florida flight tickets
Delta
Dec 6
TYS3:50 pmKnoxville McGhee Tyson
4h 10m
1 stop
ECP7:00 pmPanama City NW Florida Beaches
Dec 9
ECP1:32 pmPanama City NW Florida Beaches
4h 26m
1 stop
TYS6:58 pmKnoxville McGhee Tyson
$187
Find similar
Delta
Nov 18
TYS2:41 pmKnoxville McGhee Tyson
5h 19m
1 stop
ECP7:00 pmPanama City NW Florida Beaches
Nov 25
ECP1:32 pmPanama City NW Florida Beaches
4h 30m
1 stop
TYS7:02 pmKnoxville McGhee Tyson
$327
Find similar
Delta
Nov 20
TYS5:35 amKnoxville McGhee Tyson
4h 00m
1 stop
ECP8:35 amPanama City NW Florida Beaches
Nov 27
ECP7:23 amPanama City NW Florida Beaches
5h 21m
1 stop
TYS1:44 pmKnoxville McGhee Tyson
$337
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 24, 2025.
Use the filters below to find and compare flights from Knoxville to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sat 12/6

3:50 pm-7:00 pm

1 stop4h 10m

Panama City NW Florida Beaches

Tue 12/9

1:32 pm-6:58 pm

1 stop4h 26m

$187

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sat 12/6

5:51 pm-12:04 am

1 stop7h 13m

Panama City NW Florida Beaches

Tue 12/9

12:08 pm-11:57 pm

2 stops10h 49m

$252

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Tue 11/18

2:41 pm-7:00 pm

1 stop5h 19m

Panama City NW Florida Beaches

Tue 11/25

1:32 pm-7:02 pm

1 stop4h 30m

$327

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Thu 11/20

5:35 am-8:35 am

1 stop4h 00m

Panama City NW Florida Beaches

Thu 11/27

7:23 am-1:44 pm

1 stop5h 21m

$337

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sat 12/6

6:00 am-2:13 pm

2 stops9h 13m

Panama City NW Florida Beaches

Tue 12/9

12:08 pm-11:57 pm

2 stops10h 49m

$362

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sat 12/6

6:00 am-2:13 pm

2 stops9h 13m

Panama City NW Florida Beaches

Tue 12/9

12:08 pm-11:57 pm

2 stops10h 49m

$382

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Fri 3/20

6:30 am-2:05 pm

1 stop8h 35m

Panama City NW Florida Beaches

Sun 3/22

6:40 am-10:00 pm

2 stops14h 20m

$494

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Fri 3/20

6:30 am-12:50 pm

2 stops7h 20m

Panama City NW Florida Beaches

Sun 3/22

6:40 am-10:00 pm

2 stops14h 20m

$542

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sat 11/8

7:00 am-9:19 am

1 stop27h 19m

Panama City NW Florida Beaches

Thu 11/13

6:30 am-10:30 pm

2 stops15h 00m

$656

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sat 11/8

4:50 pm-4:23 pm

2 stops24h 33m

Panama City NW Florida Beaches

Thu 11/13

10:04 am-11:44 pm

1 stop12h 40m

$671

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Knoxville to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from Knoxville is in August. Flight prices, which tend to average around $356, are often lower during this time because this is during the off-season. The month of May is another great option to travel to Panama City, Florida, with average flight prices from Knoxville averaging around $388.

What is the cheapest day to depart on your flight to Panama City, Florida?

Our data shows that Tuesday is the least expensive day to fly to Panama City, Florida. Tickets to fly out on this day can be as low as $488. On the other hand, Saturday is the most expensive day to depart from Knoxville because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $607.

When to book flights from Knoxville to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Panama City, Florida (TYS to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Panama City, Florida

Direct flights

None
There are no direct flights from Knoxville to Panama City, Florida. There are no popular flight routes from Knoxville to Panama City, Florida.
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  • How far is Knoxville McGhee Tyson to Panama City NW Florida Beaches by plane?

    The distance between Knoxville McGhee Tyson and Panama City NW Florida Beaches is about 413.0 mi. In terms of flight time, this usually takes a little over 4h 00m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The travel and health documents you'll need for your trip to Panama City NW Florida Beaches Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama City NW Florida Beaches Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Panama City, Florida?

Best airlines flying from Knoxville to Panama City, Florida

Compare and see reviews for airlines that fly from Knoxville to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $258Free CancellationRating
7.9
7,982 reviews
Search Delta flights
American AirlinesPriceFrom $328Free CancellationRating
7.2
11,033 reviews
Search American Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Panama City?

Finding the right flight to Panama City from Knoxville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from Knoxville to Panama City with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama City from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Panama City?

momondo helps you find the best flight between Knoxville and Panama City by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Panama City right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Panama City now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama City and let you know when they change.

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