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Cheap flights from Knoxville to Panama City from $117

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Panama City departing on 2/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
6:35 am - 9:35 am
TYS
-
ECP
4h 00m
1 stop
Southwest Logo
7:30 am - 1:40 pm
ECP
-
TYS
5h 10m
1 stop
$233Southwest
Wed, Mar 18 - Wed, Mar 25
Delta Logo
6:38 pm - 11:04 pm
TYS
-
ECP
5h 26m
1 stop
Delta Logo
11:08 am - 4:06 pm
ECP
-
TYS
3h 58m
1 stop
$235Delta
Mon, Mar 16 - Mon, Mar 23
Southwest Logo
2:25 pm - 8:00 pm
TYS
-
ECP
6h 35m
1 stop
Southwest Logo
7:30 am - 8:05 pm
ECP
-
TYS
11h 35m
2 stops
$238Southwest
Wed, Mar 18 - Wed, Mar 25
Southwest Logo
6:35 am - 9:05 am
TYS
-
ECP
3h 30m
1 stop
Southwest Logo
9:55 am - 9:15 pm
ECP
-
TYS
10h 20m
2 stops
$240Southwest
Mon, Apr 13 - Thu, Apr 16
Southwest Logo
6:35 am - 1:10 pm
TYS
-
ECP
7h 35m
2 stops
Southwest Logo
7:30 am - 8:05 pm
ECP
-
TYS
11h 35m
2 stops
$243Southwest
Wed, Mar 18 - Wed, Mar 25
Southwest Logo
8:05 am - 7:35 pm
TYS
-
ECP
12h 30m
2 stops
Southwest Logo
9:55 am - 9:15 pm
ECP
-
TYS
10h 20m
2 stops
$251Southwest
Mon, Apr 13 - Thu, Apr 16
Southwest Logo
6:40 am - 9:10 am
TYS
-
ECP
3h 30m
1 stop
Southwest Logo
12:40 pm - 6:30 pm
ECP
-
TYS
4h 50m
1 stop
$257Southwest
Sun, Apr 19 - Sat, Apr 25
Southwest Logo
2:25 pm - 8:00 pm
TYS
-
ECP
6h 35m
1 stop
Southwest Logo
12:25 pm - 9:05 pm
ECP
-
TYS
7h 40m
1 stop
$261Southwest
Wed, Apr 1 - Sat, Apr 4
Southwest Logo
6:40 am - 3:30 pm
TYS
-
ECP
9h 50m
2 stops
Southwest Logo
12:40 pm - 6:30 pm
ECP
-
TYS
4h 50m
1 stop
$262Southwest
Sun, Apr 19 - Sat, Apr 25
Southwest Logo
6:35 am - 1:10 pm
TYS
-
ECP
7h 35m
2 stops
Southwest Logo
5:25 am - 12:55 pm
ECP
-
TYS
6h 30m
2 stops
$266Southwest
Wed, Apr 1 - Sun, Apr 5

Southwest flights from Knoxville to Panama City, Florida

Our best Southwest deals on Knoxville to Panama City, Florida flight tickets
Southwest
Mar 18
TYS6:35 amKnoxville McGhee Tyson
4h 00m
1 stop
ECP9:35 amPanama City NW Florida Beaches
Mar 25
ECP7:30 amPanama City NW Florida Beaches
5h 10m
1 stop
TYS1:40 pmKnoxville McGhee Tyson
$233
Southwest
Mar 18
TYS2:25 pmKnoxville McGhee Tyson
6h 35m
1 stop
ECP8:00 pmPanama City NW Florida Beaches
Mar 25
ECP7:30 amPanama City NW Florida Beaches
11h 35m
2 stops
TYS8:05 pmKnoxville McGhee Tyson
$238
Southwest
Apr 13
TYS6:35 amKnoxville McGhee Tyson
3h 30m
1 stop
ECP9:05 amPanama City NW Florida Beaches
Apr 16
ECP9:55 amPanama City NW Florida Beaches
10h 20m
2 stops
TYS9:15 pmKnoxville McGhee Tyson
$240

Delta flights from Knoxville to Panama City, Florida

Our best Delta deals on Knoxville to Panama City, Florida flight tickets
Delta
Mar 16
TYS6:38 pmKnoxville McGhee Tyson
5h 26m
1 stop
ECP11:04 pmPanama City NW Florida Beaches
Mar 23
ECP11:08 amPanama City NW Florida Beaches
3h 58m
1 stop
TYS4:06 pmKnoxville McGhee Tyson
$235
Delta
Mar 21
TYS5:40 amKnoxville McGhee Tyson
4h 00m
1 stop
ECP8:40 amPanama City NW Florida Beaches
Mar 24
ECP7:05 amPanama City NW Florida Beaches
3h 12m
1 stop
TYS11:17 amKnoxville McGhee Tyson
$300
Delta
Mar 16
TYS6:38 pmKnoxville McGhee Tyson
5h 26m
1 stop
ECP11:04 pmPanama City NW Florida Beaches
Mar 26
ECP6:43 pmPanama City NW Florida Beaches
4h 14m
1 stop
TYS11:57 pmKnoxville McGhee Tyson
$317

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Knoxville to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Wed 3/18

6:35 am-9:35 am

1 stop4h 00m

Panama City NW Florida Beaches

Wed 3/25

7:30 am-1:40 pm

1 stop5h 10m

$233

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Mon 3/16

6:38 pm-11:04 pm

1 stop5h 26m

Panama City NW Florida Beaches

Mon 3/23

11:08 am-4:06 pm

1 stop3h 58m

$235

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Wed 3/18

2:25 pm-8:00 pm

1 stop6h 35m

Panama City NW Florida Beaches

Wed 3/25

7:30 am-8:05 pm

2 stops11h 35m

$238

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Mon 4/13

6:35 am-9:05 am

1 stop3h 30m

Panama City NW Florida Beaches

Thu 4/16

9:55 am-9:15 pm

2 stops10h 20m

$240

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Wed 3/18

6:35 am-1:10 pm

2 stops7h 35m

Panama City NW Florida Beaches

Wed 3/25

7:30 am-8:05 pm

2 stops11h 35m

$243

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Mon 4/13

8:05 am-7:35 pm

2 stops12h 30m

Panama City NW Florida Beaches

Thu 4/16

9:55 am-9:15 pm

2 stops10h 20m

$251

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sun 4/19

6:40 am-9:10 am

1 stop3h 30m

Panama City NW Florida Beaches

Sat 4/25

12:40 pm-6:30 pm

1 stop4h 50m

$257

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Wed 4/1

2:25 pm-8:00 pm

1 stop6h 35m

Panama City NW Florida Beaches

Sat 4/4

12:25 pm-9:05 pm

1 stop7h 40m

$261

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sun 4/19

6:40 am-3:30 pm

2 stops9h 50m

Panama City NW Florida Beaches

Sat 4/25

12:40 pm-6:30 pm

1 stop4h 50m

$262

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Wed 4/1

6:35 am-1:10 pm

2 stops7h 35m

Panama City NW Florida Beaches

Sun 4/5

5:25 am-12:55 pm

2 stops6h 30m

$266

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Knoxville to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from Knoxville is in March. Flight prices, which tend to average around $350, are often lower during this time because this is during the off-season. The month of August is another great option to travel to Panama City, Florida, with average flight prices from Knoxville averaging around $356.

When to book flights from Knoxville to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Panama City, Florida (TYS to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Panama City, Florida

Fastest flight time

3h 30m

Direct flights

None
The fastest flight from Knoxville to Panama City, Florida takes 3h 30m
There are no direct flights from Knoxville to Panama City, Florida. There are no popular flight routes from Knoxville to Panama City, Florida.
Search flight deals

  • How far is Knoxville McGhee Tyson to Panama City NW Florida Beaches by plane?

    The distance between Knoxville McGhee Tyson and Panama City NW Florida Beaches is about 413.0 mi. In terms of flight time, this usually takes a little over 3h 30m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The travel and health documents you'll need for your trip to Panama City NW Florida Beaches Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama City NW Florida Beaches Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Panama City, Florida?

Best airlines flying from Knoxville to Panama City, Florida

Compare and see reviews for airlines that fly from Knoxville to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $228Free CancellationRating
7.9
8,128 reviews
Search Delta flights
American AirlinesPriceFrom $326Free CancellationRating
7.2
11,205 reviews
Search American Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Panama City?

Finding the right flight to Panama City from Knoxville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from Knoxville to Panama City with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama City from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Panama City?

momondo helps you find the best flight between Knoxville and Panama City by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Panama City right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Panama City now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama City and let you know when they change.

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