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Cheap flights from Knoxville to Panama City from $279

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Panama City departing on 5/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
6:40 am - 9:00 am
TYS
-
ECP
3h 20m1 stop
Southwest Logo
12:40 pm - 6:30 pm
ECP
-
TYS
4h 50m1 stop
$279Southwest
sáb., may. 2 - sáb., may. 9
Southwest Logo
6:40 am - 1:00 pm
TYS
-
ECP
7h 20m2 stops
Southwest Logo
12:40 pm - 6:30 pm
ECP
-
TYS
4h 50m1 stop
$284Southwest
sáb., may. 2 - sáb., may. 9
Southwest Logo
6:40 am - 2:30 pm
TYS
-
ECP
8h 50m2 stops
Southwest Logo
7:55 am - 6:30 pm
ECP
-
TYS
9h 35m2 stops
$295Southwest
sáb., may. 2 - sáb., may. 9
Southwest Logo
6:35 am - 9:05 am
TYS
-
ECP
3h 30m1 stop
Southwest Logo
2:50 pm - 9:05 pm
ECP
-
TYS
5h 15m1 stop
$309Southwest
sáb., mar. 7 - sáb., mar. 14
Southwest Logo
6:35 am - 3:20 pm
TYS
-
ECP
9h 45m2 stops
Southwest Logo
2:50 pm - 9:05 pm
ECP
-
TYS
5h 15m1 stop
$314Southwest
sáb., mar. 7 - sáb., mar. 14
Delta Logo
5:40 am - 9:12 am
TYS
-
ECP
4h 32m1 stop
Delta Logo
6:00 am - 10:15 am
ECP
-
TYS
3h 15m1 stop
$317Delta
mar., ene. 6 - sáb., ene. 10
Southwest Logo
6:35 am - 3:20 pm
TYS
-
ECP
9h 45m2 stops
Southwest Logo
6:35 am - 9:05 pm
ECP
-
TYS
13h 30m2 stops
$325Southwest
sáb., mar. 7 - sáb., mar. 14
Delta Logo
5:40 am - 9:12 am
TYS
-
ECP
4h 32m1 stop
Delta Logo
5:14 pm - 11:45 pm
ECP
-
TYS
5h 31m1 stop
$327Delta
jue., ene. 8 - lun., ene. 12
Southwest Logo
3:45 pm - 9:20 pm
TYS
-
ECP
6h 35m1 stop
Southwest Logo
4:55 pm - 9:15 pm
ECP
-
TYS
3h 20m1 stop
$328Southwest
vie., mar. 6 - vie., mar. 13
Southwest Logo
6:30 am - 5:20 pm
TYS
-
ECP
11h 50m2 stops
Southwest Logo
4:55 pm - 9:15 pm
ECP
-
TYS
3h 20m1 stop
$333Southwest
vie., mar. 6 - vie., mar. 13

Delta flights from Knoxville to Panama City, Florida

Our best Delta deals on Knoxville to Panama City, Florida flight tickets
Delta
Jan 6
TYS5:40 amKnoxville McGhee Tyson
4h 32m
1 stop
ECP9:12 amPanama City NW Florida Beaches
Jan 10
ECP6:00 amPanama City NW Florida Beaches
3h 15m
1 stop
TYS10:15 amKnoxville McGhee Tyson
$317
Find similar
Delta
Jan 8
TYS5:40 amKnoxville McGhee Tyson
4h 32m
1 stop
ECP9:12 amPanama City NW Florida Beaches
Jan 12
ECP5:14 pmPanama City NW Florida Beaches
5h 31m
1 stop
TYS11:45 pmKnoxville McGhee Tyson
$327
Find similar
Delta
Jan 4
TYS6:59 pmKnoxville McGhee Tyson
4h 43m
1 stop
ECP10:42 pmPanama City NW Florida Beaches
Jan 10
ECP7:20 amPanama City NW Florida Beaches
5h 30m
1 stop
TYS1:50 pmKnoxville McGhee Tyson
$337
Find similar

Southwest flights from Knoxville to Panama City, Florida

Our best Southwest deals on Knoxville to Panama City, Florida flight tickets
Southwest
May 2
TYS6:40 amKnoxville McGhee Tyson
3h 20m
1 stop
ECP9:00 amPanama City NW Florida Beaches
May 9
ECP12:40 pmPanama City NW Florida Beaches
4h 50m
1 stop
TYS6:30 pmKnoxville McGhee Tyson
$279
Find similar
Southwest
May 2
TYS6:40 amKnoxville McGhee Tyson
7h 20m
2 stops
ECP1:00 pmPanama City NW Florida Beaches
May 9
ECP12:40 pmPanama City NW Florida Beaches
4h 50m
1 stop
TYS6:30 pmKnoxville McGhee Tyson
$284
Find similar
Southwest
May 2
TYS6:40 amKnoxville McGhee Tyson
8h 50m
2 stops
ECP2:30 pmPanama City NW Florida Beaches
May 9
ECP7:55 amPanama City NW Florida Beaches
9h 35m
2 stops
TYS6:30 pmKnoxville McGhee Tyson
$295
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated diciembre 8, 2025.
Use the filters below to find and compare flights from Knoxville to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

sáb. 5/2

6:40 am-9:00 am

1 stop3h 20m

Panama City NW Florida Beaches

sáb. 5/9

12:40 pm-6:30 pm

1 stop4h 50m

$279

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

sáb. 5/2

6:40 am-1:00 pm

2 stops7h 20m

Panama City NW Florida Beaches

sáb. 5/9

12:40 pm-6:30 pm

1 stop4h 50m

$284

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

sáb. 5/2

6:40 am-2:30 pm

2 stops8h 50m

Panama City NW Florida Beaches

sáb. 5/9

7:55 am-6:30 pm

2 stops9h 35m

$295

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

sáb. 3/7

6:35 am-9:05 am

1 stop3h 30m

Panama City NW Florida Beaches

sáb. 3/14

2:50 pm-9:05 pm

1 stop5h 15m

$309

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

sáb. 3/7

6:35 am-3:20 pm

2 stops9h 45m

Panama City NW Florida Beaches

sáb. 3/14

2:50 pm-9:05 pm

1 stop5h 15m

$314

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

mar. 1/6

5:40 am-9:12 am

1 stop4h 32m

Panama City NW Florida Beaches

sáb. 1/10

6:00 am-10:15 am

1 stop3h 15m

$317

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

sáb. 3/7

6:35 am-3:20 pm

2 stops9h 45m

Panama City NW Florida Beaches

sáb. 3/14

6:35 am-9:05 pm

2 stops13h 30m

$325

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

jue. 1/8

5:40 am-9:12 am

1 stop4h 32m

Panama City NW Florida Beaches

lun. 1/12

5:14 pm-11:45 pm

1 stop5h 31m

$327

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

vie. 3/6

3:45 pm-9:20 pm

1 stop6h 35m

Panama City NW Florida Beaches

vie. 3/13

4:55 pm-9:15 pm

1 stop3h 20m

$328

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

vie. 3/6

6:30 am-5:20 pm

2 stops11h 50m

Panama City NW Florida Beaches

vie. 3/13

4:55 pm-9:15 pm

1 stop3h 20m

$333

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Knoxville to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from Knoxville is in August. Flight prices, which tend to average around $356, are often lower during this time because this is during the off-season. The month of November is another great option to travel to Panama City, Florida, with average flight prices from Knoxville averaging around $384.

What is the cheapest day to depart on your flight to Panama City, Florida?

Our data shows that Tuesday is the least expensive day to fly to Panama City, Florida. Tickets to fly out on this day can be as low as $488. On the other hand, Saturday is the most expensive day to depart from Knoxville because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $607.

When to book flights from Knoxville to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Panama City, Florida (TYS to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Panama City, Florida

Fastest flight time

3h 20m

Direct flights

None
The fastest flight from Knoxville to Panama City, Florida takes 3h 20m
There are no direct flights from Knoxville to Panama City, Florida. There are no popular flight routes from Knoxville to Panama City, Florida.
Search flight deals

  • How far is Knoxville McGhee Tyson to Panama City NW Florida Beaches by plane?

    The distance between Knoxville McGhee Tyson and Panama City NW Florida Beaches is about 413.0 mi. In terms of flight time, this usually takes a little over 3h 20m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The travel and health documents you'll need for your trip to Panama City NW Florida Beaches Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama City NW Florida Beaches Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Panama City, Florida?

Best airlines flying from Knoxville to Panama City, Florida

Compare and see reviews for airlines that fly from Knoxville to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $258Free CancellationRating
7.9
8,013 reviews
Search Delta flights
American AirlinesPriceFrom $326Free CancellationRating
7.2
11,042 reviews
Search American Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Panama City?

Finding the right flight to Panama City from Knoxville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from Knoxville to Panama City with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama City from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Panama City?

momondo helps you find the best flight between Knoxville and Panama City by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Panama City right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Panama City now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama City and let you know when they change.

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