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Cheap flights from Knoxville to Panama City from $122

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Panama City departing on 8/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:25 pm - 10:40 pm
TYS
-
ECP
4h 15m
1 stop
American Airlines Logo
5:48 pm - 10:58 pm
ECP
-
TYS
4h 10m
1 stop
$243American Airlines
Thu, Aug 20 - Sat, Aug 29
American Airlines Logo
5:15 am - 11:12 am
TYS
-
ECP
6h 57m
1 stop
American Airlines Logo
6:40 am - 11:44 am
ECP
-
TYS
4h 04m
1 stop
$243American Airlines
Tue, Aug 25 - Tue, Sep 1
Delta Logo
5:40 am - 8:14 am
TYS
-
ECP
3h 34m
1 stop
Delta Logo
5:40 pm - 10:22 pm
ECP
-
TYS
3h 42m
1 stop
$243Delta
Sat, Oct 10 - Sat, Oct 24
Delta Logo
5:40 am - 8:14 am
TYS
-
ECP
3h 34m
1 stop
Delta Logo
6:00 am - 10:54 am
ECP
-
TYS
3h 54m
1 stop
$243Delta
Sat, Oct 10 - Thu, Oct 15
Southwest Logo
2:05 pm - 9:05 pm
TYS
-
ECP
8h 00m
1 stop
Southwest Logo
7:45 am - 12:05 pm
ECP
-
TYS
3h 20m
1 stop
$243Southwest
Thu, Sep 24 - Wed, Sep 30
Southwest Logo
2:05 pm - 9:05 pm
TYS
-
ECP
8h 00m
1 stop
Southwest Logo
6:00 am - 1:25 pm
ECP
-
TYS
6h 25m
1 stop
$245Southwest
Fri, Sep 11 - Mon, Sep 14
Southwest Logo
1:55 pm - 8:30 pm
TYS
-
ECP
7h 35m
2 stops
Southwest Logo
7:45 am - 12:05 pm
ECP
-
TYS
3h 20m
1 stop
$248Southwest
Tue, Aug 25 - Tue, Sep 1
American Airlines Logo
12:09 pm - 5:16 pm
TYS
-
ECP
6h 07m
1 stop
American Airlines Logo
5:48 pm - 10:58 pm
ECP
-
TYS
4h 10m
1 stop
$289American Airlines
Fri, Aug 28 - Fri, Sep 4
United Airlines Logo
5:20 pm - 8:06 pm
TYS
-
ECP
27h 46m
1 stop
United Airlines Logo
6:30 am - 7:34 pm
ECP
-
TYS
12h 04m
1 stop
$645United Airlines
Wed, Jan 6 - Sat, Jan 9
United Airlines Logo
7:00 am - 8:06 pm
TYS
-
ECP
14h 06m
1 stop
United Airlines Logo
6:30 am - 5:37 pm
ECP
-
TYS
10h 07m
1 stop
$645United Airlines
Wed, Jan 6 - Sat, Jan 9

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Delta flights from Knoxville to Panama City, Florida

Our best Delta deals on Knoxville to Panama City, Florida flight tickets
Delta
Aug 25
TYS2:16 pmKnoxville McGhee Tyson
5h 19m
1 stop
ECP6:35 pmPanama City NW Florida Beaches
Sep 1
ECP5:26 pmPanama City NW Florida Beaches
5h 26m
1 stop
TYS11:52 pmKnoxville McGhee Tyson
$243
Delta
Sep 18
TYS6:13 pmKnoxville McGhee Tyson
3h 50m
1 stop
ECP9:03 pmPanama City NW Florida Beaches
Sep 22
ECP7:35 amPanama City NW Florida Beaches
4h 46m
1 stop
TYS1:21 pmKnoxville McGhee Tyson
$266
Delta
Sep 17
TYS7:25 pmKnoxville McGhee Tyson
5h 00m
1 stop
ECP11:25 pmPanama City NW Florida Beaches
Sep 23
ECP5:30 pmPanama City NW Florida Beaches
5h 25m
1 stop
TYS11:55 pmKnoxville McGhee Tyson
$269

Southwest flights from Knoxville to Panama City, Florida

Our best Southwest deals on Knoxville to Panama City, Florida flight tickets
Southwest
Sep 11
TYS2:05 pmKnoxville McGhee Tyson
8h 00m
1 stop
ECP9:05 pmPanama City NW Florida Beaches
Sep 14
ECP6:00 amPanama City NW Florida Beaches
6h 25m
1 stop
TYS1:25 pmKnoxville McGhee Tyson
$245
Southwest
Aug 25
TYS1:55 pmKnoxville McGhee Tyson
7h 35m
2 stops
ECP8:30 pmPanama City NW Florida Beaches
Sep 1
ECP7:45 amPanama City NW Florida Beaches
3h 20m
1 stop
TYS12:05 pmKnoxville McGhee Tyson
$248
Southwest
Aug 25
TYS8:05 amKnoxville McGhee Tyson
11h 05m
2 stops
ECP6:10 pmPanama City NW Florida Beaches
Sep 1
ECP10:30 amPanama City NW Florida Beaches
7h 25m
2 stops
TYS6:55 pmKnoxville McGhee Tyson
$253

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 1, 2026.
Use the filters below to find and compare flights from Knoxville to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Thu 8/20

7:25 pm-10:40 pm

1 stop4h 15m

Panama City NW Florida Beaches

Sat 8/29

5:48 pm-10:58 pm

1 stop4h 10m

$243

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Tue 8/25

5:15 am-11:12 am

1 stop6h 57m

Panama City NW Florida Beaches

Tue 9/1

6:40 am-11:44 am

1 stop4h 04m

$243
Quickest round-trip

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sat 10/10

5:40 am-8:14 am

1 stop3h 34m

Panama City NW Florida Beaches

Sat 10/24

5:40 pm-10:22 pm

1 stop3h 42m

$243

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sat 10/10

5:40 am-8:14 am

1 stop3h 34m

Panama City NW Florida Beaches

Thu 10/15

6:00 am-10:54 am

1 stop3h 54m

$243

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Thu 9/24

2:05 pm-9:05 pm

1 stop8h 00m

Panama City NW Florida Beaches

Wed 9/30

7:45 am-12:05 pm

1 stop3h 20m

$243

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Fri 9/11

2:05 pm-9:05 pm

1 stop8h 00m

Panama City NW Florida Beaches

Mon 9/14

6:00 am-1:25 pm

1 stop6h 25m

$245

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Tue 8/25

1:55 pm-8:30 pm

2 stops7h 35m

Panama City NW Florida Beaches

Tue 9/1

7:45 am-12:05 pm

1 stop3h 20m

$248

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Fri 8/28

12:09 pm-5:16 pm

1 stop6h 07m

Panama City NW Florida Beaches

Fri 9/4

5:48 pm-10:58 pm

1 stop4h 10m

$289

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Wed 1/6

5:20 pm-8:06 pm

1 stop27h 46m

Panama City NW Florida Beaches

Sat 1/9

6:30 am-7:34 pm

1 stop12h 04m

$645

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Wed 1/6

7:00 am-8:06 pm

1 stop14h 06m

Panama City NW Florida Beaches

Sat 1/9

6:30 am-5:37 pm

1 stop10h 07m

$645

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Knoxville to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Panama City, Florida?

Prices are currently low for flights on this route.

Typical prices usually range from $278 to $393.
The lowest price recently found on this route was $243.

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from Knoxville is in May. Flight prices, which tend to average around $312, are often lower during this time because this is during the off-season. The month of January is another great option to travel to Panama City, Florida, with average flight prices from Knoxville averaging around $326.

When to book flights from Knoxville to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Panama City, Florida (TYS to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Panama City, Florida

Fastest flight time

2h 53m

Direct flights

None
The fastest flight from Knoxville to Panama City, Florida takes 2h 53m
There are no direct flights from Knoxville to Panama City, Florida. There are no popular flight routes from Knoxville to Panama City, Florida.
Search flight deals

Frequently asked questions about flying from Knoxville to Panama City, Florida

  • How far is Knoxville McGhee Tyson to Panama City NW Florida Beaches by plane?

    The distance between Knoxville McGhee Tyson and Panama City NW Florida Beaches is about 413.0 mi. In terms of flight time, this usually takes a little over 2h 53m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Knoxville McGhee Tyson Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The travel and health documents you'll need for your trip to Panama City NW Florida Beaches Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Panama City NW Florida Beaches Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Panama City, Florida?

Best airlines flying from Knoxville to Panama City, Florida

Compare and see reviews for airlines that fly from Knoxville to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $173Free CancellationRating
7.8
8,497 reviews
Search Delta flights
SouthwestPriceFrom $247Free CancellationRating
8.0
4,229 reviews
Search Southwest flights
American AirlinesPriceFrom $326Free CancellationRating
7.1
11,845 reviews
Search American Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Panama City?

Finding the right flight to Panama City from Knoxville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from Knoxville to Panama City with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Panama City from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Panama City?

momondo helps you find the best flight between Knoxville and Panama City by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Panama City right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Panama City now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama City and let you know when they change.

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