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Cheap flights from Knoxville to New York from $149

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to New York departing on 4/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to New York

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
8:15 am - 11:55 am
TYS
-
ISP
3h 40m
1 stop
Southwest Logo
6:30 am - 5:10 pm
ISP
-
TYS
10h 40m
2 stops
$300Southwest
Wed, May 6 - Wed, May 13
Southwest Logo
12:50 pm - 10:10 pm
TYS
-
ISP
9h 20m
2 stops
Southwest Logo
6:30 am - 5:10 pm
ISP
-
TYS
10h 40m
2 stops
$305Southwest
Wed, May 6 - Wed, May 13
Multiple Airlines Logo
6:44 pm - 5:55 pm
TYS
-
ISP
23h 11m
2 stops
Multiple Airlines Logo
4:07 pm - 5:30 pm
ISP
-
TYS
25h 23m
1 stop
$367Multiple Airlines
Thu, Apr 2 - Thu, Apr 16
Southwest Logo
8:25 am - 12:35 pm
TYS
-
ISP
4h 10m
1 stop
Southwest Logo
6:10 am - 5:10 pm
ISP
-
TYS
11h 00m
2 stops
$372Southwest
Fri, Sep 4 - Mon, Sep 7
Southwest Logo
6:30 am - 5:20 pm
TYS
-
ISP
10h 50m
2 stops
Southwest Logo
6:00 am - 6:10 pm
ISP
-
TYS
12h 10m
2 stops
$384Southwest
Thu, Apr 2 - Thu, Apr 16
Southwest Logo
2:05 pm - 10:05 pm
TYS
-
ISP
8h 00m
2 stops
Southwest Logo
6:10 am - 5:10 pm
ISP
-
TYS
11h 00m
2 stops
$407Southwest
Fri, Sep 4 - Mon, Sep 7
Multiple Airlines Logo
2:06 pm - 10:30 am
TYS
-
ISP
20h 24m
1 stop
Multiple Airlines Logo
8:00 am - 10:36 am
ISP
-
TYS
26h 36m
2 stops
$414Multiple Airlines
Fri, Apr 3 - Tue, Apr 7
Southwest Logo
1:20 pm - 10:40 pm
TYS
-
ISP
9h 20m
1 stop
Southwest Logo
4:30 pm - 9:15 pm
ISP
-
TYS
4h 45m
1 stop
$432Southwest
Thu, Apr 2 - Thu, Apr 16
Southwest Logo
7:50 am - 11:40 am
TYS
-
ISP
3h 50m
1 stop
Southwest Logo
4:05 pm - 8:50 pm
ISP
-
TYS
4h 45m
1 stop
$437Southwest
Fri, Apr 3 - Tue, Apr 7
Southwest Logo
6:30 am - 5:20 pm
TYS
-
ISP
10h 50m
2 stops
Southwest Logo
6:30 am - 5:10 pm
ISP
-
TYS
10h 40m
2 stops
$447Southwest
Fri, Apr 3 - Tue, Apr 7

Southwest flights from Knoxville to Islip, New York

Our best Southwest deals on Knoxville to Islip, New York flight tickets
Southwest
May 6
TYS8:15 amKnoxville McGhee Tyson
3h 40m
1 stop
ISP11:55 amIslip Long Island
May 13
ISP6:30 amIslip Long Island
10h 40m
2 stops
TYS5:10 pmKnoxville McGhee Tyson
$300
Southwest
May 6
TYS12:50 pmKnoxville McGhee Tyson
9h 20m
2 stops
ISP10:10 pmIslip Long Island
May 13
ISP6:30 amIslip Long Island
10h 40m
2 stops
TYS5:10 pmKnoxville McGhee Tyson
$305
Southwest
Sep 4
TYS8:25 amKnoxville McGhee Tyson
4h 10m
1 stop
ISP12:35 pmIslip Long Island
Sep 7
ISP6:10 amIslip Long Island
11h 00m
2 stops
TYS5:10 pmKnoxville McGhee Tyson
$372

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Islip, New York that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 22, 2026.
Use the filters below to find and compare flights from Knoxville to Islip, New York that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleIslip

TYS - ISP

TYSISP

Knoxville McGhee Tyson

Wed 5/6

8:15 am-11:55 am

1 stop3h 40m

Islip Long Island

Wed 5/13

6:30 am-5:10 pm

2 stops10h 40m

$300

KnoxvilleIslip

TYS - ISP

TYSISP

Knoxville McGhee Tyson

Wed 5/6

12:50 pm-10:10 pm

2 stops9h 20m

Islip Long Island

Wed 5/13

6:30 am-5:10 pm

2 stops10h 40m

$305

KnoxvilleIslip

TYS - ISP

TYSISP

Knoxville McGhee Tyson

Thu 4/2

6:44 pm-5:55 pm

2 stops23h 11m

Islip Long Island

Thu 4/16

4:07 pm-5:30 pm

1 stop25h 23m

$367

KnoxvilleIslip

TYS - ISP

TYSISP

Knoxville McGhee Tyson

Fri 9/4

8:25 am-12:35 pm

1 stop4h 10m

Islip Long Island

Mon 9/7

6:10 am-5:10 pm

2 stops11h 00m

$372

KnoxvilleIslip

TYS - ISP

TYSISP

Knoxville McGhee Tyson

Thu 4/2

6:30 am-5:20 pm

2 stops10h 50m

Islip Long Island

Thu 4/16

6:00 am-6:10 pm

2 stops12h 10m

$384

KnoxvilleIslip

TYS - ISP

TYSISP

Knoxville McGhee Tyson

Fri 9/4

2:05 pm-10:05 pm

2 stops8h 00m

Islip Long Island

Mon 9/7

6:10 am-5:10 pm

2 stops11h 00m

$407

KnoxvilleIslip

TYS - ISP

TYSISP

Knoxville McGhee Tyson

Fri 4/3

2:06 pm-10:30 am

1 stop20h 24m

Islip Long Island

Tue 4/7

8:00 am-10:36 am

2 stops26h 36m

$414

KnoxvilleIslip

TYS - ISP

TYSISP

Knoxville McGhee Tyson

Thu 4/2

1:20 pm-10:40 pm

1 stop9h 20m

Islip Long Island

Thu 4/16

4:30 pm-9:15 pm

1 stop4h 45m

$432
Quickest round-trip

KnoxvilleIslip

TYS - ISP

TYSISP

Knoxville McGhee Tyson

Fri 4/3

7:50 am-11:40 am

1 stop3h 50m

Islip Long Island

Tue 4/7

4:05 pm-8:50 pm

1 stop4h 45m

$437

KnoxvilleIslip

TYS - ISP

TYSISP

Knoxville McGhee Tyson

Fri 4/3

6:30 am-5:20 pm

2 stops10h 50m

Islip Long Island

Tue 4/7

6:30 am-5:10 pm

2 stops10h 40m

$447

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
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See travel insights to New York from

How to get the cheapest flight ticket from Knoxville to Islip, New York

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Knoxville McGhee Tyson to Islip Long Island?

Southwest is the most popular carrier operating from Knoxville McGhee Tyson to Islip Long Island

What airlines fly to Islip, New York?

Delta, American Airlines and United Airlines are the top three most popular airlines that fly to Islip, New York from Knoxville according to our data. Delta is the first choice among our users, with 46% of people opting to fly with this airline when traveling to Islip, New York. Keep in mind that there are 5 different airlines that fly to Islip, New York on a routine basis, so you have a few additional options to choose from.

When to book flights from Knoxville to Islip, New York

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Islip, New York according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Islip, New York (TYS to ISP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Islip, New York

Fastest flight time

3h 40m

Direct flights

None
The fastest flight from Knoxville to Islip, New York takes 3h 40m
There are no direct flights from Knoxville to Islip, New York. There are no popular flight routes from Knoxville to Islip, New York.
Search flight deals

  • How far is Knoxville McGhee Tyson to Islip Long Island by plane?

    The straight-line distance from Knoxville McGhee Tyson to Islip Long Island is 666.2 mi. A reasonable flight in good conditions will take 3h 40m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Islip Long Island Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Islip Long Island Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Islip Long Island Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Islip Long Island Airport.

  • What documentation or ID do you need to fly to Islip Long Island Airport?

    The travel and health documents you'll need for your trip to Islip Long Island Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Islip Long Island Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near New York?

Book flights to New York if you plan to visit one of these locations
Montauk
Riverhead
Sag Harbor
Southampton
Amagansett

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Islip?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to Islip for you.

Can I find flights from Knoxville to Islip with flexible booking policies on momondo?

momondo does allow users to show only those flights to Islip from Knoxville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Knoxville to Islip?

momondo helps you find the best flight between Knoxville and Islip by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Islip right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Islip, momondo offers a useful price alert feature which will track prices for flights to Islip from Knoxville and alert you when they change.

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