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Cheap flights from Knoxville to Istanbul from $454

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Istanbul departing on 8/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Knoxville to Istanbul

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
12:09 pm - 3:00 pmTYS  Knoxville McGhee Tyson-IST Istanbul
19h 51m2 stops Charlotte Douglas London Heathrow
American Airlines Logo
8:15 am - 7:43 pmIST  Istanbul-TYS Knoxville McGhee Tyson
18h 28m2 stops London Heathrow Chicago O'Hare Intl
$904American Airlines
Mon, Sep 7 - Tue, Sep 22
British Airways Logo
7:38 am - 12:50 amTYS  Knoxville McGhee Tyson-IST Istanbul
33h 12m2 stops Philadelphia London Heathrow
British Airways Logo
2:55 pm - 8:43 pmIST  Istanbul-TYS Knoxville McGhee Tyson
37h 48m2 stops London Heathrow Philadelphia
$909British Airways
Sun, Dec 13 - Sat, Dec 19
Lufthansa Logo
6:02 pm - 9:15 pmTYS  Knoxville McGhee Tyson-IST Istanbul
44h 13m2 stops Chicago O'Hare Intl Frankfurt am Main
Lufthansa Logo
1:55 pm - 12:23 amIST  Istanbul-TYS Knoxville McGhee Tyson
17h 28m2 stops Frankfurt am Main Chicago O'Hare Intl
$934Lufthansa
Mon, Sep 7 - Tue, Sep 22
Lufthansa Logo
1:10 pm - 2:05 amTYS  Knoxville McGhee Tyson-IST Istanbul
29h 55m2 stops Washington, D.C. Dulles Intl Munich Franz Josef Strauss
Lufthansa Logo
3:45 am - 10:49 pmIST  Istanbul-TYS Knoxville McGhee Tyson
26h 04m2 stops Munich Franz Josef Strauss Chicago O'Hare Intl
$951Lufthansa
Thu, Sep 10 - Wed, Sep 16
United Airlines Logo
1:10 pm - 9:15 pmTYS  Knoxville McGhee Tyson-IST Istanbul
25h 05m2 stops Washington, D.C. Dulles Intl Frankfurt am Main
United Airlines Logo
5:40 am - 8:49 pmIST  Istanbul-TYS Knoxville McGhee Tyson
22h 09m2 stops Frankfurt am Main Chicago O'Hare Intl
$979United Airlines
Tue, Sep 22 - Tue, Sep 29
United Airlines Logo
1:10 pm - 9:25 pmTYS  Knoxville McGhee Tyson-IST Istanbul
25h 15m2 stops Washington, D.C. Dulles Intl Frankfurt am Main
United Airlines Logo
5:40 am - 8:49 pmIST  Istanbul-TYS Knoxville McGhee Tyson
22h 09m2 stops Frankfurt am Main Chicago O'Hare Intl
$998United Airlines
Wed, Sep 23 - Wed, Sep 30
American Airlines Logo
8:15 pm - 12:40 amTYS  Knoxville McGhee Tyson-IST Istanbul
21h 25m2 stops Chicago O'Hare Intl London Heathrow
American Airlines Logo
8:15 am - 10:54 pmIST  Istanbul-TYS Knoxville McGhee Tyson
21h 39m2 stops London Heathrow Charlotte Douglas
$1,037American Airlines
Thu, Oct 1 - Tue, Oct 13
United Airlines Logo
12:05 pm - 4:55 pmTYS  Knoxville McGhee Tyson-IST Istanbul
21h 50m2 stops Houston George Bush Intcntl Frankfurt am Main
United Airlines Logo
5:40 am - 2:42 pmIST  Istanbul-TYS Knoxville McGhee Tyson
40h 02m2 stops Frankfurt am Main Washington, D.C. Dulles Intl
$1,045United Airlines
Fri, Sep 25 - Fri, Oct 2
British Airways Logo
5:00 pm - 1:50 pmTYS  Knoxville McGhee Tyson-IST Istanbul
36h 50m2 stops Chicago O'Hare Intl London Heathrow
British Airways Logo
6:45 pm - 11:42 pmIST  Istanbul-TYS Knoxville McGhee Tyson
36h 57m2 stops London Heathrow Chicago O'Hare Intl
$1,051British Airways
Sun, Nov 15 - Wed, Nov 18
United Airlines Logo
11:25 am - 10:45 pmTYS  Knoxville McGhee Tyson-IST Istanbul
27h 20m2 stops Newark Frankfurt am Main
United Airlines Logo
1:55 pm - 11:59 pmIST  Istanbul-TYS Knoxville McGhee Tyson
18h 04m2 stops London Heathrow Washington, D.C. Dulles Intl
$1,086United Airlines
Sun, Nov 15 - Wed, Nov 18

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British Airways flights from Knoxville to Istanbul Airport

Our best British Airways deals on Knoxville to Istanbul Airport flight tickets
British Airways
Dec 13
TYS7:38 amKnoxville McGhee Tyson
33h 12m
2 stops
IST12:50 amIstanbul
Dec 19
IST2:55 pmIstanbul
37h 48m
2 stops
TYS8:43 pmKnoxville McGhee Tyson
$909
British Airways
Nov 15
TYS5:00 pmKnoxville McGhee Tyson
36h 50m
2 stops
IST1:50 pmIstanbul
Nov 18
IST6:45 pmIstanbul
36h 57m
2 stops
TYS11:42 pmKnoxville McGhee Tyson
$1,051

United Airlines flights from Knoxville to Istanbul Airport

Our best United Airlines deals on Knoxville to Istanbul Airport flight tickets
United Airlines
Sep 22
TYS1:10 pmKnoxville McGhee Tyson
25h 05m
2 stops
IST9:15 pmIstanbul
Sep 29
IST5:40 amIstanbul
22h 09m
2 stops
TYS8:49 pmKnoxville McGhee Tyson
$979
United Airlines
Sep 23
TYS1:10 pmKnoxville McGhee Tyson
25h 15m
2 stops
IST9:25 pmIstanbul
Sep 30
IST5:40 amIstanbul
22h 09m
2 stops
TYS8:49 pmKnoxville McGhee Tyson
$998
United Airlines
Sep 25
TYS12:05 pmKnoxville McGhee Tyson
21h 50m
2 stops
IST4:55 pmIstanbul
Oct 2
IST5:40 amIstanbul
40h 02m
2 stops
TYS2:42 pmKnoxville McGhee Tyson
$1,045

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Istanbul Airport that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 12, 2026.
Use the filters below to find and compare flights from Knoxville to Istanbul Airport that are best for you.

Fly from

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Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

KnoxvilleIstanbul

TYS Knoxville McGhee Tyson - IST Istanbul

TYSIST

Knoxville McGhee Tyson

Mon 9/7

12:09 pm-3:00 pm

2 stops19h 51m

Istanbul

Tue 9/22

8:15 am-7:43 pm

2 stops18h 28m

$904

KnoxvilleIstanbul

TYS Knoxville McGhee Tyson - IST Istanbul

TYSIST

Knoxville McGhee Tyson

Sun 12/13

7:38 am-12:50 am

2 stops33h 12m

Istanbul

Sat 12/19

2:55 pm-8:43 pm

2 stops37h 48m

$909

KnoxvilleIstanbul

TYS Knoxville McGhee Tyson - IST Istanbul

TYSIST

Knoxville McGhee Tyson

Mon 9/7

6:02 pm-9:15 pm

2 stops44h 13m

Istanbul

Tue 9/22

1:55 pm-12:23 am

2 stops17h 28m

$934

KnoxvilleIstanbul

TYS Knoxville McGhee Tyson - IST Istanbul

TYSIST

Knoxville McGhee Tyson

Thu 9/10

1:10 pm-2:05 am

2 stops29h 55m

Istanbul

Wed 9/16

3:45 am-10:49 pm

2 stops26h 04m

$951

KnoxvilleIstanbul

TYS Knoxville McGhee Tyson - IST Istanbul

TYSIST

Knoxville McGhee Tyson

Tue 9/22

1:10 pm-9:15 pm

2 stops25h 05m

Istanbul

Tue 9/29

5:40 am-8:49 pm

2 stops22h 09m

$979

KnoxvilleIstanbul

TYS Knoxville McGhee Tyson - IST Istanbul

TYSIST

Knoxville McGhee Tyson

Wed 9/23

1:10 pm-9:25 pm

2 stops25h 15m

Istanbul

Wed 9/30

5:40 am-8:49 pm

2 stops22h 09m

$998

KnoxvilleIstanbul

TYS Knoxville McGhee Tyson - IST Istanbul

TYSIST

Knoxville McGhee Tyson

Thu 10/1

8:15 pm-12:40 am

2 stops21h 25m

Istanbul

Tue 10/13

8:15 am-10:54 pm

2 stops21h 39m

$1,037

KnoxvilleIstanbul

TYS Knoxville McGhee Tyson - IST Istanbul

TYSIST

Knoxville McGhee Tyson

Fri 9/25

12:05 pm-4:55 pm

2 stops21h 50m

Istanbul

Fri 10/2

5:40 am-2:42 pm

2 stops40h 02m

$1,045

KnoxvilleIstanbul

TYS Knoxville McGhee Tyson - IST Istanbul

TYSIST

Knoxville McGhee Tyson

Sun 11/15

5:00 pm-1:50 pm

2 stops36h 50m

Istanbul

Wed 11/18

6:45 pm-11:42 pm

2 stops36h 57m

$1,051

KnoxvilleIstanbul

TYS Knoxville McGhee Tyson - IST Istanbul

TYSIST

Knoxville McGhee Tyson

Sun 11/15

11:25 am-10:45 pm

2 stops27h 20m

Istanbul

Wed 11/18

1:55 pm-11:59 pm

2 stops18h 04m

$1,086

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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See travel insights to Istanbul from

How to get the cheapest flight ticket from Knoxville to Istanbul Airport

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Knoxville McGhee Tyson to Istanbul?

Lufthansa is the most popular carrier operating from Knoxville McGhee Tyson to Istanbul

When to book flights from Knoxville to Istanbul Airport

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Istanbul Airport according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Istanbul Airport (TYS to IST) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Istanbul Airport

Fastest flight time

24h 00m

Direct flights

None
The fastest flight from Knoxville to Istanbul Airport takes 24h 00m
There are no direct flights from Knoxville to Istanbul Airport. There are no popular flight routes from Knoxville to Istanbul Airport.
Search flight deals

Frequently asked questions about flying from Knoxville to Istanbul Airport

  • How far is Knoxville McGhee Tyson to Istanbul by plane?

    Knoxville McGhee Tyson and Istanbul are 5606.4 mi apart from one another. 24h 00m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Istanbul Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Istanbul Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Istanbul Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Istanbul Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Istanbul Airport.

  • What documentation or ID do you need to fly to Istanbul Airport?

    The travel and health documents you'll need for your trip to Istanbul Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Istanbul Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Istanbul Airport?

Best airlines flying from Knoxville to Istanbul Airport

Compare and see reviews for airlines that fly from Knoxville to Istanbul Airport with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $554Free CancellationRating
7.4
10,115 reviews
Search United Airlines flights
LufthansaPriceFrom $858Free CancellationRating
6.8
8,182 reviews
Search Lufthansa flights

Traveling to a place near Istanbul?

Book flights to Istanbul if you plan to visit one of these locations
Yalova

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Istanbul?

Finding the right flight to Istanbul from Knoxville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Istanbul quick and easy, saving you time and money.

Can I find flights from Knoxville to Istanbul with flexible booking policies on momondo?

All flight searches from Knoxville to Istanbul on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to Istanbul?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Istanbul from Knoxville.

I’m not ready to book a flight from Knoxville to Istanbul right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Istanbul from Knoxville. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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