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Cheap flights from Knoxville to Italy from $427

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Italy departing on 3/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Italy

Cheap round-trip flights

Enter your travel dates to find the best prices.
Air Canada Logo
1:52 pm - 10:20 am
TYS
-
MXP
38h 28m
2 stops
Air Canada Logo
12:20 pm - 11:03 pm
MXP
-
TYS
16h 43m
2 stops
$491Air Canada
Wed, Apr 15 - Wed, Apr 22
Lufthansa Logo
1:50 pm - 4:15 pm
TYS
-
VCE
20h 25m
2 stops
Lufthansa Logo
1:00 pm - 8:47 pm
VCE
-
TYS
36h 47m
2 stops
$495Lufthansa
Tue, Mar 3 - Tue, Mar 10
United Airlines Logo
9:40 am - 10:20 am
TYS
-
MXP
42h 40m
2 stops
United Airlines Logo
3:20 pm - 11:03 pm
MXP
-
TYS
13h 43m
1 stop
$496United Airlines
Tue, Apr 14 - Wed, Apr 22
United Airlines Logo
10:55 am - 7:30 am
TYS
-
MXP
15h 35m
2 stops
United Airlines Logo
9:45 am - 10:19 am
MXP
-
TYS
29h 34m
2 stops
$497United Airlines
Tue, Mar 10 - Tue, Mar 17
British Airways Logo
8:48 pm - 1:25 pm
TYS
-
LIN
34h 37m
2 stops
British Airways Logo
7:25 am - 8:18 pm
LIN
-
TYS
18h 53m
2 stops
$503British Airways
Tue, Apr 14 - Wed, Apr 22
American Airlines Logo
5:06 pm - 3:00 pm
TYS
-
LIN
15h 54m
2 stops
American Airlines Logo
10:25 am - 9:57 pm
LIN
-
TYS
17h 32m
2 stops
$508American Airlines
Wed, Apr 15 - Wed, Apr 22
Delta Logo
7:38 am - 10:35 am
TYS
-
MXP
20h 57m
2 stops
Delta Logo
12:00 pm - 9:04 am
MXP
-
TYS
27h 04m
2 stops
$516Delta
Sun, Feb 15 - Wed, Feb 25
Delta Logo
7:38 am - 10:35 am
TYS
-
MXP
20h 57m
2 stops
Delta Logo
11:05 am - 9:04 am
MXP
-
TYS
27h 59m
1 stop
$517Delta
Sun, Feb 15 - Wed, Feb 25
American Airlines Logo
4:15 pm - 4:50 pm
TYS
-
VCE
19h 35m
2 stops
American Airlines Logo
1:40 pm - 9:05 pm
VCE
-
TYS
13h 25m
1 stop
$587American Airlines
Mon, Mar 23 - Wed, Apr 1
British Airways Logo
2:49 pm - 1:25 pm
TYS
-
LIN
16h 36m
2 stops
British Airways Logo
7:25 am - 9:57 pm
LIN
-
TYS
20h 32m
2 stops
$624British Airways
Wed, Apr 22 - Thu, Apr 30

United Airlines flights from Knoxville to Italy

Our best United Airlines deals on Knoxville to Italy flight tickets
United Airlines
Apr 14
TYS9:40 amKnoxville McGhee Tyson
42h 40m
2 stops
MXP10:20 amMilan Malpensa
Apr 22
MXP3:20 pmMilan Malpensa
13h 43m
1 stop
TYS11:03 pmKnoxville McGhee Tyson
$496
United Airlines
Mar 10
TYS10:55 amKnoxville McGhee Tyson
15h 35m
2 stops
MXP7:30 amMilan Malpensa
Mar 17
MXP9:45 amMilan Malpensa
29h 34m
2 stops
TYS10:19 amKnoxville McGhee Tyson
$497
United Airlines
Mar 19
TYS2:21 pmKnoxville McGhee Tyson
20h 54m
2 stops
VCE4:15 pmVenice Marco Polo
Mar 26
VCE6:40 amVenice Marco Polo
17h 49m
2 stops
TYS7:29 pmKnoxville McGhee Tyson
$507

American Airlines flights from Knoxville to Italy

Our best American Airlines deals on Knoxville to Italy flight tickets
American Airlines
Apr 15
TYS5:06 pmKnoxville McGhee Tyson
15h 54m
2 stops
LIN3:00 pmMilan Linate
Apr 22
LIN10:25 amMilan Linate
17h 32m
2 stops
TYS9:57 pmKnoxville McGhee Tyson
$508
American Airlines
Mar 23
TYS4:15 pmKnoxville McGhee Tyson
19h 35m
2 stops
VCE4:50 pmVenice Marco Polo
Apr 1
VCE1:40 pmVenice Marco Polo
13h 25m
1 stop
TYS9:05 pmKnoxville McGhee Tyson
$587
American Airlines
Mar 23
TYS5:47 pmKnoxville McGhee Tyson
18h 03m
2 stops
VCE4:50 pmVenice Marco Polo
Apr 1
VCE1:40 pmVenice Marco Polo
13h 25m
1 stop
TYS9:05 pmKnoxville McGhee Tyson
$588

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from Knoxville to Italy that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleMilan

TYS - MXP

TYSMXP

Knoxville McGhee Tyson

Wed 4/15

1:52 pm-10:20 am

2 stops38h 28m

Milan Malpensa

Wed 4/22

12:20 pm-11:03 pm

2 stops16h 43m

$491

KnoxvilleVenice

TYS - VCE

TYSVCE

Knoxville McGhee Tyson

Tue 3/3

1:50 pm-4:15 pm

2 stops20h 25m

Venice Marco Polo

Tue 3/10

1:00 pm-8:47 pm

2 stops36h 47m

$495

KnoxvilleMilan

TYS - MXP

TYSMXP

Knoxville McGhee Tyson

Tue 4/14

9:40 am-10:20 am

2 stops42h 40m

Milan Malpensa

Wed 4/22

3:20 pm-11:03 pm

1 stop13h 43m

$496

KnoxvilleMilan

TYS - MXP

TYSMXP

Knoxville McGhee Tyson

Tue 3/10

10:55 am-7:30 am

2 stops15h 35m

Milan Malpensa

Tue 3/17

9:45 am-10:19 am

2 stops29h 34m

$497

KnoxvilleMilan

TYS - LIN

TYSLIN

Knoxville McGhee Tyson

Tue 4/14

8:48 pm-1:25 pm

2 stops34h 37m

Milan Linate

Wed 4/22

7:25 am-8:18 pm

2 stops18h 53m

$503

KnoxvilleMilan

TYS - LIN

TYSLIN

Knoxville McGhee Tyson

Wed 4/15

5:06 pm-3:00 pm

2 stops15h 54m

Milan Linate

Wed 4/22

10:25 am-9:57 pm

2 stops17h 32m

$508

KnoxvilleMilan

TYS - MXP

TYSMXP

Knoxville McGhee Tyson

Sun 2/15

7:38 am-10:35 am

2 stops20h 57m

Milan Malpensa

Wed 2/25

12:00 pm-9:04 am

2 stops27h 04m

$516

KnoxvilleMilan

TYS - MXP

TYSMXP

Knoxville McGhee Tyson

Sun 2/15

7:38 am-10:35 am

2 stops20h 57m

Milan Malpensa

Wed 2/25

11:05 am-9:04 am

1 stop27h 59m

$517

KnoxvilleVenice

TYS - VCE

TYSVCE

Knoxville McGhee Tyson

Mon 3/23

4:15 pm-4:50 pm

2 stops19h 35m

Venice Marco Polo

Wed 4/1

1:40 pm-9:05 pm

1 stop13h 25m

$587

KnoxvilleMilan

TYS - LIN

TYSLIN

Knoxville McGhee Tyson

Wed 4/22

2:49 pm-1:25 pm

2 stops16h 36m

Milan Linate

Thu 4/30

7:25 am-9:57 pm

2 stops20h 32m

$624

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Italy from

How to get the cheapest flight ticket from Knoxville to Italy

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Italy?

The cheapest month to fly to Italy from Knoxville is in December. Flight prices, which tend to average around $705, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of December, then book flights to Italy from Knoxville during November instead. Flights to Italy in November, while not as cheap as those in December, still average around $783.

Can stopping save me money on Knoxville to Italy flights?

You could potentially save up to 46% on your flight if you consider stops on a Knoxville to Italy flight.

Cheap Knoxville to Italy flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Italy

Fastest flight time

13h 23m

Direct flights

None
The fastest flight from Knoxville to Italy takes 13h 23m
There are no direct flights from Knoxville to Italy. There are no popular flight routes from Knoxville to Italy.
Search flight deals

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Italy?

    Prices for flights from Knoxville McGhee Tyson Airport to Italy are refreshed on a daily basis.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Italy?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Italy?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Italy.

  • What documentation or ID do you need to fly to Italy?

    The travel and health documents you'll need for your trip to Italy may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Italy. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Knoxville to Italy

Compare and see reviews for airlines that fly from Knoxville to Italy with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $500Free CancellationRating
7.4
9,236 reviews
Search United Airlines flights
DeltaPriceFrom $501Free CancellationRating
7.9
8,146 reviews
Search Delta flights
American AirlinesPriceFrom $749Free CancellationRating
7.2
11,222 reviews
Search American Airlines flights
British AirwaysPriceFrom $765Free CancellationRating
6.7
7,715 reviews
Search British Airways flights
LufthansaPriceFrom $793Free CancellationRating
6.8
7,759 reviews
Search Lufthansa flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Italy?

It is quick and easy to find Knoxville to Italy flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Italy that suits you.

Can I find flights from Knoxville to Italy with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Knoxville to Italy flights to just show those with flexible booking policies.

How can momondo help me find flights from Knoxville to Italy?

momondo provides multiple filters to help you find the best flight to Italy from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to Italy right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Italy now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Italy and let you know when they change.

An easier way to manage your Italy trip

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