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Cheap flights from Knoxville to Indianapolis from $133

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Indianapolis departing on 9/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to Indianapolis

Cheap round-trip flights

American Airlines Logo
5:45 pm - 10:02 pmTYS-IND
4h 17m1 stop
American Airlines Logo
1:04 pm - 8:43 pmIND-TYS
7h 39m1 stop
$225American Airlines
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Tue, Dec 16 - Thu, Jan 1
Delta Logo
5:25 am - 9:00 amTYS-IND
3h 35m1 stop
Delta Logo
11:26 am - 2:46 pmIND-TYS
3h 20m1 stop
$239Delta
Find Deal
Tue, Nov 11 - Sat, Nov 15
American Airlines Logo
7:18 am - 3:18 pmTYS-IND
8h 00m1 stop
American Airlines Logo
6:56 pm - 11:50 pmIND-TYS
4h 54m1 stop
$249American Airlines
Find Deal
Thu, Oct 2 - Mon, Oct 6
Allegiant Air Logo
8:38 am - 11:38 pmTYS-IND
15h 00m1 stop
Allegiant Air Logo
3:15 pm - 11:38 pmIND-TYS
8h 23m1 stop
$264Allegiant Air
Find Deal
Fri, Oct 3 - Mon, Oct 6
Multiple Airlines Logo
4:04 pm - 9:00 pmTYS-IND
28h 56m1 stop
Multiple Airlines Logo
1:57 pm - 11:14 pmIND-TYS
9h 17m1 stop
$271Multiple Airlines
Find Deal
Tue, Nov 11 - Fri, Nov 14
Allegiant Air Logo
8:40 am - 2:32 pmTYS-IND
5h 52m1 stop
Allegiant Air Logo
3:22 pm - 11:14 pmIND-TYS
7h 52m1 stop
$277Allegiant Air
Find Deal
Fri, Nov 7 - Mon, Nov 10
American Airlines Logo
7:38 am - 3:19 pmTYS-IND
7h 41m1 stop
American Airlines Logo
8:11 pm - 11:47 pmIND-TYS
3h 36m1 stop
$278American Airlines
Find Deal
Tue, Dec 16 - Mon, Dec 29
Delta Logo
5:25 am - 9:04 amTYS-IND
3h 39m1 stop
Delta Logo
2:42 pm - 7:27 pmIND-TYS
4h 45m1 stop
$283Delta
Find Deal
Mon, Dec 15 - Tue, Dec 30
United Airlines Logo
9:10 am - 3:46 pmTYS-IND
6h 36m1 stop
United Airlines Logo
11:20 am - 5:00 pmIND-TYS
5h 40m1 stop
$377United Airlines
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Mon, Dec 15 - Thu, Jan 1
United Airlines Logo
1:52 pm - 5:44 pmTYS-IND
3h 52m1 stop
United Airlines Logo
5:45 am - 10:56 amIND-TYS
5h 11m1 stop
$424United Airlines
Find Deal
Tue, Dec 16 - Sun, Dec 28

Delta flights from Knoxville to Indianapolis

Our best Delta deals on Knoxville to Indianapolis flight tickets
Delta
Nov 11
TYS5:25 amKnoxville McGhee Tyson
3h 35m
1 stop
IND9:00 amIndianapolis
Nov 15
IND11:26 amIndianapolis
3h 20m
1 stop
TYS2:46 pmKnoxville McGhee Tyson
$239
Find similar
Delta
Dec 15
TYS5:25 amKnoxville McGhee Tyson
3h 39m
1 stop
IND9:04 amIndianapolis
Dec 30
IND2:42 pmIndianapolis
4h 45m
1 stop
TYS7:27 pmKnoxville McGhee Tyson
$283
Find similar
Delta
Sep 30
TYS6:08 pmKnoxville McGhee Tyson
3h 56m
1 stop
IND10:04 pmIndianapolis
Oct 4
IND6:51 pmIndianapolis
4h 53m
1 stop
TYS11:44 pmKnoxville McGhee Tyson
$304
Find similar

Allegiant Air flights from Knoxville to Indianapolis

Our best Allegiant Air deals on Knoxville to Indianapolis flight tickets
Allegiant Air
Oct 3
TYS8:38 amKnoxville McGhee Tyson
15h 00m
1 stop
IND11:38 pmIndianapolis
Oct 6
IND3:15 pmIndianapolis
8h 23m
1 stop
TYS11:38 pmKnoxville McGhee Tyson
$264
Find similar
Allegiant Air
Nov 7
TYS8:40 amKnoxville McGhee Tyson
5h 52m
1 stop
IND2:32 pmIndianapolis
Nov 10
IND3:22 pmIndianapolis
7h 52m
1 stop
TYS11:14 pmKnoxville McGhee Tyson
$277
Find similar
Allegiant Air
Oct 2
TYS5:44 pmKnoxville McGhee Tyson
17h 33m
2 stops
IND11:17 amIndianapolis
Oct 6
IND3:15 pmIndianapolis
8h 23m
1 stop
TYS11:38 pmKnoxville McGhee Tyson
$316
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Indianapolis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Knoxville to Indianapolis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Tue 12/16

5:45 pm-10:02 pm

1 stop4h 17m

Indianapolis

Thu 1/1

1:04 pm-8:43 pm

1 stop7h 39m

$225

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Tue 11/11

5:25 am-9:00 am

1 stop3h 35m

Indianapolis

Sat 11/15

11:26 am-2:46 pm

1 stop3h 20m

$239

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Thu 10/2

7:18 am-3:18 pm

1 stop8h 00m

Indianapolis

Mon 10/6

6:56 pm-11:50 pm

1 stop4h 54m

$249

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Fri 10/3

8:38 am-11:38 pm

1 stop15h 00m

Indianapolis

Mon 10/6

3:15 pm-11:38 pm

1 stop8h 23m

$264

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Tue 11/11

4:04 pm-9:00 pm

1 stop28h 56m

Indianapolis

Fri 11/14

1:57 pm-11:14 pm

1 stop9h 17m

$271

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Fri 11/7

8:40 am-2:32 pm

1 stop5h 52m

Indianapolis

Mon 11/10

3:22 pm-11:14 pm

1 stop7h 52m

$277

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Tue 12/16

7:38 am-3:19 pm

1 stop7h 41m

Indianapolis

Mon 12/29

8:11 pm-11:47 pm

1 stop3h 36m

$278

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Mon 12/15

5:25 am-9:04 am

1 stop3h 39m

Indianapolis

Tue 12/30

2:42 pm-7:27 pm

1 stop4h 45m

$283

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Mon 12/15

9:10 am-3:46 pm

1 stop6h 36m

Indianapolis

Thu 1/1

11:20 am-5:00 pm

1 stop5h 40m

$377

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Tue 12/16

1:52 pm-5:44 pm

1 stop3h 52m

Indianapolis

Sun 12/28

5:45 am-10:56 am

1 stop5h 11m

$424

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Indianapolis from

How to get the cheapest flight ticket from Knoxville to Indianapolis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Indianapolis?

In general, April is the cheapest month to fly from Knoxville to Indianapolis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $233. If you are unable to visit Indianapolis during the month of April, then departing from Knoxville during the month May is also very affordable. Most momondo users find prices during this month for around $246.

What is the cheapest day to depart on your flight to Indianapolis?

Our data shows that Saturday is the least expensive day to fly to Indianapolis. Tickets to fly out on this day can be as low as $238. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Indianapolis on Sunday is $522.

What is the cheapest time of day to depart on your flight to Indianapolis?

Flying to Indianapolis from Knoxville in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $238 when looking at flights departing in the afternoon. If you have a flexible travel schedule, then try to avoid flying at noon when prices are $387 on average. Flights to Indianapolis from Knoxville at noon are generally more expensive because this time of day is more convenient for travelers’ schedules.

How have Knoxville to Indianapolis flight prices changed over time?

When to book flights from Knoxville to Indianapolis

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Indianapolis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Indianapolis (TYS to IND) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Indianapolis

Direct flights

None
There are no direct flights from Knoxville to Indianapolis. There are no popular flight routes from Knoxville to Indianapolis.
Search flight deals

  • How far is Knoxville McGhee Tyson to Indianapolis by plane?

    Knoxville McGhee Tyson and Indianapolis are 289.8 mi apart from one another. By plane, this route typically takes 3h 12m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Indianapolis Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Indianapolis Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Indianapolis Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Indianapolis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Indianapolis Airport.

  • What documentation or ID do you need to fly to Indianapolis Airport?

    The travel and health documents you'll need for your trip to Indianapolis Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Indianapolis Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Indianapolis?

Best airlines flying from Knoxville to Indianapolis

Compare and see reviews for airlines that fly from Knoxville to Indianapolis with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $208Free CancellationRating
7.9
7,961 reviews
Search Delta flights
American AirlinesPriceFrom $218Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $223Free CancellationRating
7.4
8,926 reviews
Search United Airlines flights

Traveling to a place near Indianapolis?

Book flights to Indianapolis if you plan to visit one of these locations
Terre Haute
Bloomington
Kokomo
Muncie
Anderson
Plainfield
Greenwood
Noblesville
Fishers
Carmel
Shelbyville
West Lafayette
Seymour
Franklin
Brownsburg
Crawfordsville
Speedway
Greenfield
Westfield
Mooresville

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Indianapolis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to Indianapolis for you.

Can I find flights from Knoxville to Indianapolis with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Knoxville to Indianapolis flights to just show those with flexible booking policies.

How can momondo help me find flights from Knoxville to Indianapolis?

momondo provides multiple filters to help you find the best flight to Indianapolis from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to Indianapolis right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Indianapolis flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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