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Cheap flights from Knoxville to Indianapolis from $109

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Indianapolis departing on 4/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to Indianapolis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
9:32 pm - 10:32 am
TYS
-
IND
13h 00m
2 stops
Multiple Airlines Logo
5:59 pm - 10:24 pm
IND
-
TYS
28h 25m
1 stop
$242Multiple Airlines
Thu, Apr 23 - Sun, Apr 26
Multiple Airlines Logo
1:14 pm - 10:32 am
TYS
-
IND
21h 18m
2 stops
Multiple Airlines Logo
5:59 pm - 5:30 pm
IND
-
TYS
23h 31m
1 stop
$248Multiple Airlines
Thu, Apr 23 - Sun, Apr 26
Multiple Airlines Logo
5:10 pm - 7:38 am
TYS
-
IND
14h 28m
1 stop
Multiple Airlines Logo
5:59 pm - 10:24 pm
IND
-
TYS
28h 25m
1 stop
$252Multiple Airlines
Thu, Apr 23 - Sun, Apr 26
Multiple Airlines Logo
5:10 pm - 7:38 am
TYS
-
IND
14h 28m
1 stop
Multiple Airlines Logo
5:59 pm - 10:24 pm
IND
-
TYS
28h 25m
1 stop
$256Multiple Airlines
Thu, Apr 23 - Sun, Apr 26
Delta Logo
5:40 am - 10:28 am
TYS
-
IND
4h 48m
1 stop
Delta Logo
7:05 am - 11:17 am
IND
-
TYS
4h 12m
1 stop
$271Delta
Wed, Apr 15 - Wed, Apr 22
Multiple Airlines Logo
9:32 pm - 10:34 am
TYS
-
IND
13h 02m
2 stops
Multiple Airlines Logo
5:59 pm - 10:24 pm
IND
-
TYS
28h 25m
1 stop
$274Multiple Airlines
Sun, Apr 19 - Sun, Apr 26
Southwest Logo
7:05 am - 5:15 pm
TYS
-
IND
10h 10m
2 stops
Southwest Logo
10:40 am - 5:10 pm
IND
-
TYS
6h 30m
1 stop
$276Southwest
Wed, Apr 15 - Wed, Apr 22
Multiple Airlines Logo
5:10 pm - 11:23 am
TYS
-
IND
18h 13m
2 stops
Multiple Airlines Logo
8:34 pm - 9:48 pm
IND
-
TYS
25h 14m
1 stop
$285Multiple Airlines
Thu, Apr 9 - Thu, Apr 16
United Airlines Logo
7:00 am - 11:17 am
TYS
-
IND
4h 17m
1 stop
United Airlines Logo
6:00 am - 10:08 am
IND
-
TYS
4h 08m
1 stop
$287United Airlines
Thu, Apr 9 - Thu, Apr 16
American Airlines Logo
5:00 am - 9:41 am
TYS
-
IND
4h 41m
1 stop
American Airlines Logo
3:48 pm - 8:18 pm
IND
-
TYS
4h 30m
1 stop
$304American Airlines
Fri, May 15 - Sat, May 16

United Airlines flights from Knoxville to Indianapolis

Our best United Airlines deals on Knoxville to Indianapolis flight tickets
United Airlines
Apr 9
TYS7:00 amKnoxville McGhee Tyson
4h 17m
1 stop
IND11:17 amIndianapolis
Apr 16
IND6:00 amIndianapolis
4h 08m
1 stop
TYS10:08 amKnoxville McGhee Tyson
$287
United Airlines
Apr 10
TYS7:00 amKnoxville McGhee Tyson
5h 52m
1 stop
IND12:52 pmIndianapolis
Apr 17
IND4:10 pmIndianapolis
6h 24m
1 stop
TYS10:34 pmKnoxville McGhee Tyson
$357
United Airlines
Mar 28
TYS7:00 amKnoxville McGhee Tyson
4h 21m
1 stop
IND11:21 amIndianapolis
Apr 1
IND6:00 amIndianapolis
4h 08m
1 stop
TYS10:08 amKnoxville McGhee Tyson
$437

Allegiant Air flights from Knoxville to Indianapolis

Our best Allegiant Air deals on Knoxville to Indianapolis flight tickets
Allegiant Air
Mar 20
TYS9:26 amKnoxville McGhee Tyson
7h 53m
1 stop
IND5:19 pmIndianapolis
Mar 23
IND6:41 pmIndianapolis
19h 29m
1 stop
TYS2:10 pmKnoxville McGhee Tyson
$348
Allegiant Air
Mar 20
TYS9:26 amKnoxville McGhee Tyson
7h 53m
1 stop
IND5:19 pmIndianapolis
Mar 23
IND6:41 pmIndianapolis
19h 29m
1 stop
TYS2:10 pmKnoxville McGhee Tyson
$378
Allegiant Air
Mar 19
TYS9:00 amKnoxville McGhee Tyson
14h 33m
1 stop
IND11:33 pmIndianapolis
Mar 23
IND6:41 pmIndianapolis
19h 29m
1 stop
TYS2:10 pmKnoxville McGhee Tyson
$388

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Indianapolis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 17, 2026.
Use the filters below to find and compare flights from Knoxville to Indianapolis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Thu 4/23

9:32 pm-10:32 am

2 stops13h 00m

Indianapolis

Sun 4/26

5:59 pm-10:24 pm

1 stop28h 25m

$242

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Thu 4/23

1:14 pm-10:32 am

2 stops21h 18m

Indianapolis

Sun 4/26

5:59 pm-5:30 pm

1 stop23h 31m

$248

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Thu 4/23

5:10 pm-7:38 am

1 stop14h 28m

Indianapolis

Sun 4/26

5:59 pm-10:24 pm

1 stop28h 25m

$252

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Thu 4/23

5:10 pm-7:38 am

1 stop14h 28m

Indianapolis

Sun 4/26

5:59 pm-10:24 pm

1 stop28h 25m

$256

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Wed 4/15

5:40 am-10:28 am

1 stop4h 48m

Indianapolis

Wed 4/22

7:05 am-11:17 am

1 stop4h 12m

$271

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Sun 4/19

9:32 pm-10:34 am

2 stops13h 02m

Indianapolis

Sun 4/26

5:59 pm-10:24 pm

1 stop28h 25m

$274

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Wed 4/15

7:05 am-5:15 pm

2 stops10h 10m

Indianapolis

Wed 4/22

10:40 am-5:10 pm

1 stop6h 30m

$276

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Thu 4/9

5:10 pm-11:23 am

2 stops18h 13m

Indianapolis

Thu 4/16

8:34 pm-9:48 pm

1 stop25h 14m

$285
Quickest round-trip

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Thu 4/9

7:00 am-11:17 am

1 stop4h 17m

Indianapolis

Thu 4/16

6:00 am-10:08 am

1 stop4h 08m

$287

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Fri 5/15

5:00 am-9:41 am

1 stop4h 41m

Indianapolis

Sat 5/16

3:48 pm-8:18 pm

1 stop4h 30m

$304

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Knoxville to Indianapolis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Indianapolis?

In general, May is the cheapest month to fly from Knoxville to Indianapolis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $238. If you are unable to visit Indianapolis during the month of May, then departing from Knoxville during the month August is also very affordable. Most momondo users find prices during this month for around $248.

How have Knoxville to Indianapolis flight prices changed over time?

When to book flights from Knoxville to Indianapolis

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Indianapolis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Indianapolis (TYS to IND) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Indianapolis

Fastest flight time

3h 55m

Direct flights

None
The fastest flight from Knoxville to Indianapolis takes 3h 55m
There are no direct flights from Knoxville to Indianapolis. There are no popular flight routes from Knoxville to Indianapolis.
Search flight deals

  • How far is Knoxville McGhee Tyson to Indianapolis by plane?

    Knoxville McGhee Tyson and Indianapolis are 289.8 mi apart from one another. By plane, this route typically takes 3h 55m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Indianapolis Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Indianapolis Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Indianapolis Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Indianapolis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Indianapolis Airport.

  • What documentation or ID do you need to fly to Indianapolis Airport?

    The travel and health documents you'll need for your trip to Indianapolis Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Indianapolis Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Indianapolis?

Best airlines flying from Knoxville to Indianapolis

Compare and see reviews for airlines that fly from Knoxville to Indianapolis with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $208Free CancellationRating
7.9
8,288 reviews
Search Delta flights
American AirlinesPriceFrom $218Free CancellationRating
7.1
11,468 reviews
Search American Airlines flights

Traveling to a place near Indianapolis?

Book flights to Indianapolis if you plan to visit one of these locations
Terre Haute
Bloomington
Kokomo
Muncie
Plainfield
Anderson
Greenwood
Noblesville
Carmel
Fishers
Shelbyville
Franklin
Seymour
West Lafayette
Speedway
Brownsburg
Crawfordsville
Westfield
Greenfield
Mooresville

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Indianapolis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to Indianapolis for you.

Can I find flights from Knoxville to Indianapolis with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Knoxville to Indianapolis flights to just show those with flexible booking policies.

How can momondo help me find flights from Knoxville to Indianapolis?

momondo provides multiple filters to help you find the best flight to Indianapolis from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to Indianapolis right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Indianapolis flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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