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Cheap flights from Knoxville to Indianapolis from $132

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Indianapolis departing on 1/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
12:55 pm - 11:15 pm
TYS
-
IND
10h 20m1 stop
Allegiant Air Logo
9:00 am - 11:05 pm
IND
-
TYS
14h 05m1 stop
$199Allegiant Air
Mon, Feb 2 - Thu, Feb 5
Multiple Airlines Logo
9:29 am - 7:31 pm
TYS
-
IND
10h 02m1 stop
Multiple Airlines Logo
7:30 am - 11:05 pm
IND
-
TYS
15h 35m1 stop
$201Multiple Airlines
Thu, Jan 15 - Thu, Jan 22
Multiple Airlines Logo
1:39 pm - 9:43 am
TYS
-
IND
44h 04m2 stops
Multiple Airlines Logo
7:30 am - 11:05 pm
IND
-
TYS
15h 35m1 stop
$207Multiple Airlines
Thu, Jan 15 - Thu, Jan 22
Multiple Airlines Logo
6:00 am - 10:48 pm
TYS
-
IND
16h 48m2 stops
Multiple Airlines Logo
9:00 am - 11:05 pm
IND
-
TYS
14h 05m1 stop
$209Multiple Airlines
Mon, Feb 2 - Thu, Feb 5
Multiple Airlines Logo
12:55 pm - 2:43 pm
TYS
-
IND
25h 48m1 stop
Multiple Airlines Logo
10:38 am - 5:28 pm
IND
-
TYS
6h 50m1 stop
$222Multiple Airlines
Fri, Jan 9 - Mon, Jan 12
United Airlines Logo
2:25 pm - 7:02 pm
TYS
-
IND
4h 37m1 stop
United Airlines Logo
7:15 am - 1:24 pm
IND
-
TYS
6h 09m1 stop
$237United Airlines
Tue, Jan 13 - Tue, Jan 20
Multiple Airlines Logo
7:15 am - 10:48 pm
TYS
-
IND
15h 33m3 stops
Multiple Airlines Logo
9:00 am - 11:05 pm
IND
-
TYS
14h 05m1 stop
$240Multiple Airlines
Mon, Feb 2 - Thu, Feb 5
Multiple Airlines Logo
1:39 pm - 10:42 am
TYS
-
IND
21h 03m2 stops
Multiple Airlines Logo
7:30 am - 11:05 pm
IND
-
TYS
15h 35m1 stop
$246Multiple Airlines
Sun, Jan 11 - Sun, Jan 18
United Airlines Logo
11:10 am - 2:57 pm
TYS
-
IND
3h 47m1 stop
United Airlines Logo
2:00 pm - 8:52 pm
IND
-
TYS
6h 52m1 stop
$251United Airlines
Wed, Jan 7 - Sat, Jan 10
American Airlines Logo
5:17 pm - 11:27 pm
TYS
-
IND
6h 10m1 stop
American Airlines Logo
6:10 am - 1:54 pm
IND
-
TYS
7h 44m2 stops
$256American Airlines
Wed, Jan 7 - Sat, Jan 10

United Airlines flights from Knoxville to Indianapolis

Our best United Airlines deals on Knoxville to Indianapolis flight tickets
United Airlines
Jan 13
TYS2:25 pmKnoxville McGhee Tyson
4h 37m
1 stop
IND7:02 pmIndianapolis
Jan 20
IND7:15 amIndianapolis
6h 09m
1 stop
TYS1:24 pmKnoxville McGhee Tyson
$237
Find similar
United Airlines
Dec 31
TYS5:45 amKnoxville McGhee Tyson
4h 44m
1 stop
IND10:29 amIndianapolis
Jan 4
IND5:45 amIndianapolis
5h 11m
1 stop
TYS10:56 amKnoxville McGhee Tyson
$315
Find similar
United Airlines
Feb 6
TYS6:45 amKnoxville McGhee Tyson
4h 47m
1 stop
IND11:32 amIndianapolis
Feb 9
IND11:25 amIndianapolis
5h 28m
1 stop
TYS4:53 pmKnoxville McGhee Tyson
$317
Find similar

American Airlines flights from Knoxville to Indianapolis

Our best American Airlines deals on Knoxville to Indianapolis flight tickets
American Airlines
Feb 21
TYS6:00 amKnoxville McGhee Tyson
7h 47m
1 stop
IND1:47 pmIndianapolis
Feb 22
IND5:29 pmIndianapolis
6h 25m
1 stop
TYS11:54 pmKnoxville McGhee Tyson
$284
Find similar
American Airlines
Jan 7
TYS6:05 amKnoxville McGhee Tyson
4h 16m
1 stop
IND10:21 amIndianapolis
Jan 9
IND8:35 amIndianapolis
5h 19m
1 stop
TYS1:54 pmKnoxville McGhee Tyson
$304
Find similar
American Airlines
Dec 30
TYS7:48 amKnoxville McGhee Tyson
5h 30m
1 stop
IND1:18 pmIndianapolis
Jan 1
IND11:00 amIndianapolis
4h 56m
1 stop
TYS3:56 pmKnoxville McGhee Tyson
$320
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Indianapolis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Knoxville to Indianapolis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Mon 2/2

12:55 pm-11:15 pm

1 stop10h 20m

Indianapolis

Thu 2/5

9:00 am-11:05 pm

1 stop14h 05m

$199

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Thu 1/15

9:29 am-7:31 pm

1 stop10h 02m

Indianapolis

Thu 1/22

7:30 am-11:05 pm

1 stop15h 35m

$201

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Thu 1/15

1:39 pm-9:43 am

2 stops44h 04m

Indianapolis

Thu 1/22

7:30 am-11:05 pm

1 stop15h 35m

$207

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Mon 2/2

6:00 am-10:48 pm

2 stops16h 48m

Indianapolis

Thu 2/5

9:00 am-11:05 pm

1 stop14h 05m

$209

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Fri 1/9

12:55 pm-2:43 pm

1 stop25h 48m

Indianapolis

Mon 1/12

10:38 am-5:28 pm

1 stop6h 50m

$222

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Tue 1/13

2:25 pm-7:02 pm

1 stop4h 37m

Indianapolis

Tue 1/20

7:15 am-1:24 pm

1 stop6h 09m

$237

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Mon 2/2

7:15 am-10:48 pm

3 stops15h 33m

Indianapolis

Thu 2/5

9:00 am-11:05 pm

1 stop14h 05m

$240

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Sun 1/11

1:39 pm-10:42 am

2 stops21h 03m

Indianapolis

Sun 1/18

7:30 am-11:05 pm

1 stop15h 35m

$246

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Wed 1/7

11:10 am-2:57 pm

1 stop3h 47m

Indianapolis

Sat 1/10

2:00 pm-8:52 pm

1 stop6h 52m

$251

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Wed 1/7

5:17 pm-11:27 pm

1 stop6h 10m

Indianapolis

Sat 1/10

6:10 am-1:54 pm

2 stops7h 44m

$256

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
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See travel insights to Indianapolis from

How to get the cheapest flight ticket from Knoxville to Indianapolis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Indianapolis?

In general, April is the cheapest month to fly from Knoxville to Indianapolis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $233. If you are unable to visit Indianapolis during the month of April, then departing from Knoxville during the month December is also very affordable. Most momondo users find prices during this month for around $242.

What is the cheapest day to depart on your flight to Indianapolis?

Our data shows that Saturday is the least expensive day to fly to Indianapolis. Tickets to fly out on this day can be as low as $238. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Indianapolis on Sunday is $522.

What is the cheapest time of day to depart on your flight to Indianapolis?

Flying to Indianapolis from Knoxville in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $238 when looking at flights departing in the afternoon. If you have a flexible travel schedule, then try to avoid flying at noon when prices are $387 on average. Flights to Indianapolis from Knoxville at noon are generally more expensive because this time of day is more convenient for travelers’ schedules.

How have Knoxville to Indianapolis flight prices changed over time?

As of December 2025, prices for Knoxville to Indianapolis flights are approximately 76% more expensive when compared to flights at the same time last year.

When to book flights from Knoxville to Indianapolis

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Indianapolis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Indianapolis (TYS to IND) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Indianapolis

Fastest flight time

5h 16m

Direct flights

None
The fastest flight from Knoxville to Indianapolis takes 5h 16m
There are no direct flights from Knoxville to Indianapolis. There are no popular flight routes from Knoxville to Indianapolis.
Search flight deals

  • How far is Knoxville McGhee Tyson to Indianapolis by plane?

    Knoxville McGhee Tyson and Indianapolis are 289.8 mi apart from one another. By plane, this route typically takes 5h 16m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Indianapolis Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Indianapolis Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Indianapolis Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Indianapolis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Indianapolis Airport.

  • What documentation or ID do you need to fly to Indianapolis Airport?

    The travel and health documents you'll need for your trip to Indianapolis Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Indianapolis Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Indianapolis?

Best airlines flying from Knoxville to Indianapolis

Compare and see reviews for airlines that fly from Knoxville to Indianapolis with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $208Free CancellationRating
7.9
8,005 reviews
Search Delta flights
American AirlinesPriceFrom $218Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights

Traveling to a place near Indianapolis?

Book flights to Indianapolis if you plan to visit one of these locations
Terre Haute
Bloomington
Kokomo
Muncie
Anderson
Plainfield
Greenwood
Noblesville
Fishers
Carmel
Shelbyville
West Lafayette
Seymour
Franklin
Brownsburg
Speedway
Crawfordsville
Greenfield
Westfield
Mooresville

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Indianapolis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to Indianapolis for you.

Can I find flights from Knoxville to Indianapolis with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Knoxville to Indianapolis flights to just show those with flexible booking policies.

How can momondo help me find flights from Knoxville to Indianapolis?

momondo provides multiple filters to help you find the best flight to Indianapolis from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to Indianapolis right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Indianapolis flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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