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Cheap flights from Knoxville to Indianapolis from $118

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Indianapolis departing on 12/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

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Multiple Airlines Logo
6:30 am - 6:24 pmTYS-IND
11h 54m1 stop
Multiple Airlines Logo
8:00 am - 10:42 pmIND-TYS
14h 42m1 stop
$216Multiple Airlines
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Thu, Dec 4 - Sun, Dec 7
Multiple Airlines Logo
9:23 am - 10:58 amTYS-IND
25h 35m1 stop
Multiple Airlines Logo
8:00 am - 10:42 pmIND-TYS
14h 42m1 stop
$232Multiple Airlines
Find Deal
Fri, Dec 5 - Sun, Dec 7
Multiple Airlines Logo
7:30 am - 9:36 pmTYS-IND
38h 06m2 stops
Multiple Airlines Logo
5:05 am - 12:57 pmIND-TYS
7h 52m1 stop
$234Multiple Airlines
Find Deal
Sat, Nov 15 - Wed, Nov 19
Allegiant Air Logo
8:20 am - 7:57 pmTYS-IND
11h 37m1 stop
Allegiant Air Logo
8:00 am - 10:42 pmIND-TYS
14h 42m1 stop
$259Allegiant Air
Find Deal
Fri, Dec 5 - Sun, Dec 7
American Airlines Logo
8:06 am - 12:07 pmTYS-IND
4h 01m1 stop
American Airlines Logo
1:04 pm - 8:43 pmIND-TYS
7h 39m1 stop
$279American Airlines
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Tue, Dec 16 - Tue, Dec 30
American Airlines Logo
6:00 am - 12:36 pmTYS-IND
6h 36m1 stop
American Airlines Logo
8:11 pm - 11:47 pmIND-TYS
3h 36m1 stop
$284American Airlines
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Tue, Dec 16 - Mon, Dec 29
Delta Logo
7:30 am - 11:15 amTYS-IND
3h 45m1 stop
Delta Logo
6:05 am - 11:47 amIND-TYS
5h 42m1 stop
$317Delta
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Tue, Mar 10 - Wed, Mar 11
Allegiant Air Logo
9:35 pm - 9:07 amTYS-IND
11h 32m1 stop
Allegiant Air Logo
8:00 am - 10:26 pmIND-TYS
14h 26m1 stop
$333Allegiant Air
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Fri, Nov 21 - Sun, Nov 23
United Airlines Logo
1:52 pm - 5:44 pmTYS-IND
3h 52m1 stop
United Airlines Logo
7:15 am - 11:59 pmIND-TYS
16h 44m2 stops
$404United Airlines
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Tue, Dec 16 - Thu, Jan 1
United Airlines Logo
7:00 am - 11:23 amTYS-IND
4h 23m1 stop
United Airlines Logo
7:15 am - 2:48 pmIND-TYS
7h 33m2 stops
$449United Airlines
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Tue, Dec 16 - Thu, Jan 1

American Airlines flights from Knoxville to Indianapolis

Our best American Airlines deals on Knoxville to Indianapolis flight tickets
American Airlines
Dec 16
TYS8:06 amKnoxville McGhee Tyson
4h 01m
1 stop
IND12:07 pmIndianapolis
Dec 30
IND1:04 pmIndianapolis
7h 39m
1 stop
TYS8:43 pmKnoxville McGhee Tyson
$279
Find similar
American Airlines
Dec 16
TYS6:00 amKnoxville McGhee Tyson
6h 36m
1 stop
IND12:36 pmIndianapolis
Dec 29
IND8:11 pmIndianapolis
3h 36m
1 stop
TYS11:47 pmKnoxville McGhee Tyson
$284
Find similar
American Airlines
Dec 16
TYS6:05 amKnoxville McGhee Tyson
4h 19m
1 stop
IND10:24 amIndianapolis
Dec 30
IND5:32 pmIndianapolis
4h 26m
1 stop
TYS9:58 pmKnoxville McGhee Tyson
$299
Find similar

United Airlines flights from Knoxville to Indianapolis

Our best United Airlines deals on Knoxville to Indianapolis flight tickets
United Airlines
Dec 16
TYS1:52 pmKnoxville McGhee Tyson
3h 52m
1 stop
IND5:44 pmIndianapolis
Jan 1
IND7:15 amIndianapolis
16h 44m
2 stops
TYS11:59 pmKnoxville McGhee Tyson
$404
Find similar
United Airlines
Dec 16
TYS7:00 amKnoxville McGhee Tyson
4h 23m
1 stop
IND11:23 amIndianapolis
Jan 1
IND7:15 amIndianapolis
7h 33m
2 stops
TYS2:48 pmKnoxville McGhee Tyson
$449
Find similar
United Airlines
Dec 16
TYS1:52 pmKnoxville McGhee Tyson
9h 04m
2 stops
IND10:56 pmIndianapolis
Dec 29
IND6:00 amIndianapolis
4h 15m
1 stop
TYS10:15 amKnoxville McGhee Tyson
$591
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Indianapolis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from Knoxville to Indianapolis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Thu 12/4

6:30 am-6:24 pm

1 stop11h 54m

Indianapolis

Sun 12/7

8:00 am-10:42 pm

1 stop14h 42m

$216

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Fri 12/5

9:23 am-10:58 am

1 stop25h 35m

Indianapolis

Sun 12/7

8:00 am-10:42 pm

1 stop14h 42m

$232

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Sat 11/15

7:30 am-9:36 pm

2 stops38h 06m

Indianapolis

Wed 11/19

5:05 am-12:57 pm

1 stop7h 52m

$234

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Fri 12/5

8:20 am-7:57 pm

1 stop11h 37m

Indianapolis

Sun 12/7

8:00 am-10:42 pm

1 stop14h 42m

$259

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Tue 12/16

8:06 am-12:07 pm

1 stop4h 01m

Indianapolis

Tue 12/30

1:04 pm-8:43 pm

1 stop7h 39m

$279

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Tue 12/16

6:00 am-12:36 pm

1 stop6h 36m

Indianapolis

Mon 12/29

8:11 pm-11:47 pm

1 stop3h 36m

$284

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Tue 3/10

7:30 am-11:15 am

1 stop3h 45m

Indianapolis

Wed 3/11

6:05 am-11:47 am

1 stop5h 42m

$317

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Fri 11/21

9:35 pm-9:07 am

1 stop11h 32m

Indianapolis

Sun 11/23

8:00 am-10:26 pm

1 stop14h 26m

$333

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Tue 12/16

1:52 pm-5:44 pm

1 stop3h 52m

Indianapolis

Thu 1/1

7:15 am-11:59 pm

2 stops16h 44m

$404

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Tue 12/16

7:00 am-11:23 am

1 stop4h 23m

Indianapolis

Thu 1/1

7:15 am-2:48 pm

2 stops7h 33m

$449

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Indianapolis from

How to get the cheapest flight ticket from Knoxville to Indianapolis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Indianapolis?

In general, April is the cheapest month to fly from Knoxville to Indianapolis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $233. If you are unable to visit Indianapolis during the month of April, then departing from Knoxville during the month May is also very affordable. Most momondo users find prices during this month for around $246.

What is the cheapest day to depart on your flight to Indianapolis?

Our data shows that Saturday is the least expensive day to fly to Indianapolis. Tickets to fly out on this day can be as low as $238. Be sure to avoid booking your departure on a Sunday as prices are generally higher than usual. According to our data, the average ticket price to Indianapolis on Sunday is $522.

What is the cheapest time of day to depart on your flight to Indianapolis?

Flying to Indianapolis from Knoxville in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $238 when looking at flights departing in the afternoon. If you have a flexible travel schedule, then try to avoid flying at noon when prices are $387 on average. Flights to Indianapolis from Knoxville at noon are generally more expensive because this time of day is more convenient for travelers’ schedules.

How have Knoxville to Indianapolis flight prices changed over time?

As of November 2025, prices for Knoxville to Indianapolis flights are approximately 37% cheaper when compared to flights at the same time last year.

When to book flights from Knoxville to Indianapolis

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Indianapolis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Indianapolis (TYS to IND) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Indianapolis

Direct flights

None
There are no direct flights from Knoxville to Indianapolis. There are no popular flight routes from Knoxville to Indianapolis.
Search flight deals

  • How far is Knoxville McGhee Tyson to Indianapolis by plane?

    Knoxville McGhee Tyson and Indianapolis are 289.8 mi apart from one another. By plane, this route typically takes 3h 45m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Indianapolis Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Indianapolis Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Indianapolis Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Indianapolis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Indianapolis Airport.

  • What documentation or ID do you need to fly to Indianapolis Airport?

    The travel and health documents you'll need for your trip to Indianapolis Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Indianapolis Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Indianapolis?

Best airlines flying from Knoxville to Indianapolis

Compare and see reviews for airlines that fly from Knoxville to Indianapolis with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $208Free CancellationRating
7.9
8,002 reviews
Search Delta flights
American AirlinesPriceFrom $218Free CancellationRating
7.2
11,038 reviews
Search American Airlines flights
United AirlinesPriceFrom $223Free CancellationRating
7.4
8,997 reviews
Search United Airlines flights

Traveling to a place near Indianapolis?

Book flights to Indianapolis if you plan to visit one of these locations
Terre Haute
Bloomington
Kokomo
Muncie
Anderson
Plainfield
Greenwood
Noblesville
Fishers
Carmel
Shelbyville
West Lafayette
Seymour
Franklin
Speedway
Crawfordsville
Brownsburg
Greenfield
Westfield
Mooresville

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Indianapolis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to Indianapolis for you.

Can I find flights from Knoxville to Indianapolis with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Knoxville to Indianapolis flights to just show those with flexible booking policies.

How can momondo help me find flights from Knoxville to Indianapolis?

momondo provides multiple filters to help you find the best flight to Indianapolis from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to Indianapolis right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Indianapolis flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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