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Cheap flights from Knoxville to Indianapolis from $135

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Indianapolis departing on 3/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to Indianapolis

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:00 am - 9:41 am
TYS
-
IND
4h 41m
1 stop
American Airlines Logo
7:13 am - 11:18 am
IND
-
TYS
4h 05m
1 stop
$300American Airlines
Fri, May 8 - Sat, May 9
United Airlines Logo
7:00 am - 11:17 am
TYS
-
IND
4h 17m
1 stop
United Airlines Logo
11:04 am - 4:52 pm
IND
-
TYS
5h 48m
1 stop
$317United Airlines
Fri, Apr 24 - Sun, Apr 26
Southwest Logo
6:35 am - 4:05 pm
TYS
-
IND
9h 30m
2 stops
Southwest Logo
6:45 am - 11:40 am
IND
-
TYS
4h 55m
1 stop
$350Southwest
Fri, May 8 - Sat, May 9
Multiple Airlines Logo
1:15 pm - 9:49 am
TYS
-
IND
20h 34m
1 stop
Multiple Airlines Logo
12:12 pm - 9:57 pm
IND
-
TYS
9h 45m
2 stops
$356Multiple Airlines
Fri, Apr 24 - Sun, Apr 26
Southwest Logo
6:35 am - 4:05 pm
TYS
-
IND
9h 30m
2 stops
Southwest Logo
5:10 am - 6:30 pm
IND
-
TYS
13h 20m
2 stops
$361Southwest
Fri, May 8 - Sat, May 9
Multiple Airlines Logo
9:43 pm - 10:32 pm
TYS
-
IND
24h 49m
1 stop
Multiple Airlines Logo
12:16 pm - 6:27 pm
IND
-
TYS
30h 11m
2 stops
$398Multiple Airlines
Sun, Mar 15 - Sun, Mar 22
United Airlines Logo
7:00 am - 1:08 pm
TYS
-
IND
6h 08m
1 stop
United Airlines Logo
7:01 am - 11:57 pm
IND
-
TYS
16h 56m
2 stops
$405United Airlines
Thu, May 14 - Thu, May 28
United Airlines Logo
6:45 am - 11:26 am
TYS
-
IND
4h 41m
1 stop
United Airlines Logo
4:05 pm - 8:37 pm
IND
-
TYS
4h 32m
1 stop
$407United Airlines
Tue, Feb 17 - Sat, Feb 21
Multiple Airlines Logo
4:04 pm - 11:04 am
TYS
-
IND
43h 00m
2 stops
Multiple Airlines Logo
5:45 am - 1:04 pm
IND
-
TYS
7h 19m
1 stop
$421Multiple Airlines
Tue, Feb 17 - Sat, Feb 21
United Airlines Logo
9:40 am - 6:57 pm
TYS
-
IND
9h 17m
1 stop
United Airlines Logo
7:53 pm - 3:15 pm
IND
-
TYS
19h 22m
1 stop
$427United Airlines
Sat, Feb 14 - Wed, Feb 18

American Airlines flights from Knoxville to Indianapolis

Our best American Airlines deals on Knoxville to Indianapolis flight tickets
American Airlines
May 8
TYS5:00 amKnoxville McGhee Tyson
4h 41m
1 stop
IND9:41 amIndianapolis
May 9
IND7:13 amIndianapolis
4h 05m
1 stop
TYS11:18 amKnoxville McGhee Tyson
$300
American Airlines
Apr 26
TYS5:00 amKnoxville McGhee Tyson
4h 41m
1 stop
IND9:41 amIndianapolis
Apr 28
IND9:57 amIndianapolis
5h 41m
1 stop
TYS3:38 pmKnoxville McGhee Tyson
$310

Southwest flights from Knoxville to Indianapolis

Our best Southwest deals on Knoxville to Indianapolis flight tickets
Southwest
Apr 26
TYS6:40 amKnoxville McGhee Tyson
5h 15m
1 stop
IND11:55 amIndianapolis
Apr 28
IND6:10 amIndianapolis
8h 10m
2 stops
TYS2:20 pmKnoxville McGhee Tyson
$340
Southwest
May 8
TYS6:35 amKnoxville McGhee Tyson
9h 30m
2 stops
IND4:05 pmIndianapolis
May 9
IND6:45 amIndianapolis
4h 55m
1 stop
TYS11:40 amKnoxville McGhee Tyson
$350
Southwest
May 8
TYS6:35 amKnoxville McGhee Tyson
9h 30m
2 stops
IND4:05 pmIndianapolis
May 9
IND5:10 amIndianapolis
13h 20m
2 stops
TYS6:30 pmKnoxville McGhee Tyson
$361

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Indianapolis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Knoxville to Indianapolis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Fri 5/8

5:00 am-9:41 am

1 stop4h 41m

Indianapolis

Sat 5/9

7:13 am-11:18 am

1 stop4h 05m

$300

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Fri 4/24

7:00 am-11:17 am

1 stop4h 17m

Indianapolis

Sun 4/26

11:04 am-4:52 pm

1 stop5h 48m

$317

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Fri 5/8

6:35 am-4:05 pm

2 stops9h 30m

Indianapolis

Sat 5/9

6:45 am-11:40 am

1 stop4h 55m

$350

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Fri 4/24

1:15 pm-9:49 am

1 stop20h 34m

Indianapolis

Sun 4/26

12:12 pm-9:57 pm

2 stops9h 45m

$356

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Fri 5/8

6:35 am-4:05 pm

2 stops9h 30m

Indianapolis

Sat 5/9

5:10 am-6:30 pm

2 stops13h 20m

$361

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Sun 3/15

9:43 pm-10:32 pm

1 stop24h 49m

Indianapolis

Sun 3/22

12:16 pm-6:27 pm

2 stops30h 11m

$398

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Thu 5/14

7:00 am-1:08 pm

1 stop6h 08m

Indianapolis

Thu 5/28

7:01 am-11:57 pm

2 stops16h 56m

$405

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Tue 2/17

6:45 am-11:26 am

1 stop4h 41m

Indianapolis

Sat 2/21

4:05 pm-8:37 pm

1 stop4h 32m

$407

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Tue 2/17

4:04 pm-11:04 am

2 stops43h 00m

Indianapolis

Sat 2/21

5:45 am-1:04 pm

1 stop7h 19m

$421

KnoxvilleIndianapolis

TYS - IND

TYSIND

Knoxville McGhee Tyson

Sat 2/14

9:40 am-6:57 pm

1 stop9h 17m

Indianapolis

Wed 2/18

7:53 pm-3:15 pm

1 stop19h 22m

$427

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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See travel insights to Indianapolis from

How to get the cheapest flight ticket from Knoxville to Indianapolis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Indianapolis?

In general, April is the cheapest month to fly from Knoxville to Indianapolis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $233. If you are unable to visit Indianapolis during the month of April, then departing from Knoxville during the month May is also very affordable. Most momondo users find prices during this month for around $246.

How have Knoxville to Indianapolis flight prices changed over time?

When to book flights from Knoxville to Indianapolis

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Indianapolis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Indianapolis (TYS to IND) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Indianapolis

Fastest flight time

3h 55m

Direct flights

None
The fastest flight from Knoxville to Indianapolis takes 3h 55m
There are no direct flights from Knoxville to Indianapolis. There are no popular flight routes from Knoxville to Indianapolis.
Search flight deals

  • How far is Knoxville McGhee Tyson to Indianapolis by plane?

    Knoxville McGhee Tyson and Indianapolis are 289.8 mi apart from one another. By plane, this route typically takes 3h 55m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Indianapolis Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Indianapolis Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Indianapolis Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Indianapolis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Indianapolis Airport.

  • What documentation or ID do you need to fly to Indianapolis Airport?

    The travel and health documents you'll need for your trip to Indianapolis Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Indianapolis Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Indianapolis?

Best airlines flying from Knoxville to Indianapolis

Compare and see reviews for airlines that fly from Knoxville to Indianapolis with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $208Free CancellationRating
7.9
8,138 reviews
Search Delta flights
American AirlinesPriceFrom $218Free CancellationRating
7.2
11,216 reviews
Search American Airlines flights

Traveling to a place near Indianapolis?

Book flights to Indianapolis if you plan to visit one of these locations
Terre Haute
Bloomington
Kokomo
Muncie
Plainfield
Anderson
Greenwood
Noblesville
Fishers
Carmel
Shelbyville
West Lafayette
Franklin
Brownsburg
Seymour
Speedway
Crawfordsville
Westfield
Greenfield
Mooresville

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Indianapolis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to Indianapolis for you.

Can I find flights from Knoxville to Indianapolis with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Knoxville to Indianapolis flights to just show those with flexible booking policies.

How can momondo help me find flights from Knoxville to Indianapolis?

momondo provides multiple filters to help you find the best flight to Indianapolis from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to Indianapolis right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Indianapolis flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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