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Cheap flights from Knoxville to Gainesville from $160

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Gainesville departing on 10/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Gainesville

Cheap round-trip flights

American Airlines Logo
5:05 am - 10:21 amTYS-GNV
5h 16m1 stop
American Airlines Logo
4:43 pm - 11:03 pmGNV-TYS
6h 20m1 stop
$239American Airlines
Find Deal
Fri, Sep 5 - Tue, Sep 9
American Airlines Logo
5:19 pm - 11:59 pmTYS-GNV
6h 40m2 stops
American Airlines Logo
4:43 pm - 11:03 pmGNV-TYS
6h 20m1 stop
$244American Airlines
Find Deal
Fri, Sep 5 - Tue, Sep 9
American Airlines Logo
5:05 am - 10:21 amTYS-GNV
5h 16m1 stop
American Airlines Logo
2:00 pm - 7:46 pmGNV-TYS
5h 46m1 stop
$278American Airlines
Find Deal
Fri, Sep 12 - Sun, Sep 14
American Airlines Logo
3:09 pm - 11:59 pmTYS-GNV
8h 50m2 stops
American Airlines Logo
6:13 am - 1:43 pmGNV-TYS
7h 30m2 stops
$299American Airlines
Find Deal
Fri, Sep 5 - Tue, Sep 9
American Airlines Logo
2:08 pm - 11:59 pmTYS-GNV
9h 51m2 stops
American Airlines Logo
2:00 pm - 7:46 pmGNV-TYS
5h 46m1 stop
$332American Airlines
Find Deal
Fri, Sep 12 - Sun, Sep 14
American Airlines Logo
6:18 pm - 10:03 pmTYS-GNV
3h 45m1 stop
American Airlines Logo
8:03 pm - 11:45 pmGNV-TYS
3h 42m1 stop
$403American Airlines
Find Deal
Thu, Jan 1 - Wed, Jan 7
American Airlines Logo
5:05 am - 10:21 amTYS-GNV
5h 16m1 stop
American Airlines Logo
6:25 am - 12:23 pmGNV-TYS
5h 58m1 stop
$408American Airlines
Find Deal
Mon, Sep 8 - Thu, Sep 18
American Airlines Logo
7:43 pm - 11:26 pmTYS-GNV
3h 43m1 stop
American Airlines Logo
7:44 pm - 11:50 pmGNV-TYS
4h 06m1 stop
$452American Airlines
Find Deal
Fri, Oct 24 - Mon, Oct 27
American Airlines Logo
5:08 am - 10:47 amTYS-GNV
5h 39m1 stop
American Airlines Logo
6:24 am - 2:13 pmGNV-TYS
7h 49m2 stops
$453American Airlines
Find Deal
Thu, Jan 1 - Wed, Jan 7
Delta Logo
10:05 am - 2:59 pmTYS-GNV
4h 54m1 stop
Delta Logo
6:04 am - 9:00 amGNV-TYS
2h 56m1 stop
$517Delta
Find Deal
Fri, Oct 24 - Mon, Oct 27

American Airlines flights from Knoxville to Gainesville

Our best American Airlines deals on Knoxville to Gainesville flight tickets
American Airlines
Sep 5
TYS5:05 amKnoxville McGhee Tyson
5h 16m
1 stop
GNV10:21 amGainesville Regional
Sep 9
GNV4:43 pmGainesville Regional
6h 20m
1 stop
TYS11:03 pmKnoxville McGhee Tyson
$239
Find similar
American Airlines
Sep 5
TYS5:19 pmKnoxville McGhee Tyson
6h 40m
2 stops
GNV11:59 pmGainesville Regional
Sep 9
GNV4:43 pmGainesville Regional
6h 20m
1 stop
TYS11:03 pmKnoxville McGhee Tyson
$244
Find similar
American Airlines
Sep 12
TYS5:05 amKnoxville McGhee Tyson
5h 16m
1 stop
GNV10:21 amGainesville Regional
Sep 14
GNV2:00 pmGainesville Regional
5h 46m
1 stop
TYS7:46 pmKnoxville McGhee Tyson
$278
Find similar

Delta flights from Knoxville to Gainesville

Our best Delta deals on Knoxville to Gainesville flight tickets
Delta
Oct 24
TYS10:05 amKnoxville McGhee Tyson
4h 54m
1 stop
GNV2:59 pmGainesville Regional
Oct 27
GNV6:04 amGainesville Regional
2h 56m
1 stop
TYS9:00 amKnoxville McGhee Tyson
$517
Find similar
Delta
Aug 25
TYS5:45 amKnoxville McGhee Tyson
3h 47m
1 stop
GNV9:32 amGainesville Regional
Aug 26
GNV2:10 pmGainesville Regional
3h 09m
1 stop
TYS5:19 pmKnoxville McGhee Tyson
$592
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Gainesville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 21, 2025.
Use the filters below to find and compare flights from Knoxville to Gainesville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Fri 9/5

5:05 am-10:21 am

1 stop5h 16m

Gainesville Regional

Tue 9/9

4:43 pm-11:03 pm

1 stop6h 20m

$239

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Fri 9/5

5:19 pm-11:59 pm

2 stops6h 40m

Gainesville Regional

Tue 9/9

4:43 pm-11:03 pm

1 stop6h 20m

$244

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Fri 9/12

5:05 am-10:21 am

1 stop5h 16m

Gainesville Regional

Sun 9/14

2:00 pm-7:46 pm

1 stop5h 46m

$278

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Fri 9/5

3:09 pm-11:59 pm

2 stops8h 50m

Gainesville Regional

Tue 9/9

6:13 am-1:43 pm

2 stops7h 30m

$299

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Fri 9/12

2:08 pm-11:59 pm

2 stops9h 51m

Gainesville Regional

Sun 9/14

2:00 pm-7:46 pm

1 stop5h 46m

$332

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Thu 1/1

6:18 pm-10:03 pm

1 stop3h 45m

Gainesville Regional

Wed 1/7

8:03 pm-11:45 pm

1 stop3h 42m

$403

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Mon 9/8

5:05 am-10:21 am

1 stop5h 16m

Gainesville Regional

Thu 9/18

6:25 am-12:23 pm

1 stop5h 58m

$408

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Fri 10/24

7:43 pm-11:26 pm

1 stop3h 43m

Gainesville Regional

Mon 10/27

7:44 pm-11:50 pm

1 stop4h 06m

$452

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Thu 1/1

5:08 am-10:47 am

1 stop5h 39m

Gainesville Regional

Wed 1/7

6:24 am-2:13 pm

2 stops7h 49m

$453

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Fri 10/24

10:05 am-2:59 pm

1 stop4h 54m

Gainesville Regional

Mon 10/27

6:04 am-9:00 am

1 stop2h 56m

$517

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Gainesville from

How to get the cheapest flight ticket from Knoxville to Gainesville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Gainesville?

The cheapest day to depart on your flight to Gainesville is on a Tuesday when prices can be found for as low as $430. This is often the case because there is less demand to fly during this day of the week. Flights from Knoxville to Gainesville on a Friday will generally be more expensive and average around $550. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Gainesville?

In the morning is the cheapest time of day to fly from Knoxville to Gainesville when you can find flight prices for as low as $477. Flying to Gainesville in the morning is an ideal time because this is during off-peak travel hours. Flights to Gainesville are more costly in the afternoon, with an average ticket price of $488. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

When to book flights from Knoxville to Gainesville

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Gainesville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Gainesville (TYS to GNV) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Gainesville

Fastest flight time

1h 20m

Direct flights

Sat

Airports in Gainesville

1 airport
The fastest flight from Knoxville to Gainesville takes 1h 20m
Direct flights go from Knoxville to Gainesville on Saturday. There are no airlines offering direct flights.
There is 1 airport near Gainesville: Gainesville Regional (GNV)
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  • How far is Knoxville McGhee Tyson to Gainesville Regional by plane?

    The distance between Knoxville McGhee Tyson and Gainesville Regional is about 445.3 mi. Flights usually cover this in 3h 43m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Gainesville Regional Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Gainesville Regional Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Gainesville Regional Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Gainesville Regional Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Knoxville McGhee Tyson Airport to Gainesville Regional Airport.

  • What documentation or ID do you need to fly to Gainesville Regional Airport?

    The required travel and health documents for your Gainesville Regional Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Gainesville Regional Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Gainesville?

Best airlines flying from Knoxville to Gainesville

Compare and see reviews for airlines that fly from Knoxville to Gainesville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $228Free CancellationRating
7.9
7,981 reviews
Search Delta flights
American AirlinesPriceFrom $268Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Gainesville?

Book flights to Gainesville if you plan to visit one of these locations
Lake City
Alachua
Trenton

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Gainesville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to Gainesville. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to Gainesville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Gainesville from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Gainesville?

momondo helps you find the best flight between Knoxville and Gainesville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Gainesville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Gainesville, momondo offers a useful price alert feature which will track prices for flights to Gainesville from Knoxville and alert you when they change.

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