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Cheap flights from Knoxville to Gainesville from $268

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Gainesville departing on 6/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Gainesville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:59 pm - 12:33 am
TYS
-
GNV
4h 34m
1 stop
American Airlines Logo
7:32 pm - 11:47 pm
GNV
-
TYS
4h 15m
1 stop
$359American Airlines
Fri, Jun 19 - Fri, Jun 26
Delta Logo
5:40 am - 9:30 am
TYS
-
GNV
3h 50m
1 stop
Delta Logo
7:04 pm - 11:54 pm
GNV
-
TYS
4h 50m
1 stop
$387Delta
Fri, Jun 12 - Sun, Jun 14
American Airlines Logo
1:00 pm - 11:59 pm
TYS
-
GNV
10h 59m
2 stops
American Airlines Logo
7:32 pm - 11:47 pm
GNV
-
TYS
4h 15m
1 stop
$392American Airlines
Fri, Jun 12 - Sun, Jun 14
Delta Logo
11:56 am - 2:55 pm
TYS
-
GNV
2h 59m
1 stop
Delta Logo
7:01 pm - 11:52 pm
GNV
-
TYS
4h 51m
1 stop
$403Delta
Wed, Jun 3 - Mon, Aug 3
American Airlines Logo
1:00 pm - 11:59 pm
TYS
-
GNV
10h 59m
2 stops
American Airlines Logo
7:32 pm - 11:51 pm
GNV
-
TYS
4h 19m
1 stop
$408American Airlines
Wed, Jun 3 - Mon, Aug 3
American Airlines Logo
3:40 pm - 11:59 pm
TYS
-
GNV
8h 19m
2 stops
American Airlines Logo
7:32 pm - 11:47 pm
GNV
-
TYS
4h 15m
1 stop
$432American Airlines
Sat, Jun 13 - Sun, Jun 14
American Airlines Logo
3:40 pm - 11:59 pm
TYS
-
GNV
8h 19m
2 stops
American Airlines Logo
7:32 pm - 11:47 pm
GNV
-
TYS
4h 15m
1 stop
$433American Airlines
Fri, Jun 19 - Fri, Jun 26
Delta Logo
5:40 am - 9:25 am
TYS
-
GNV
3h 45m
1 stop
Delta Logo
6:33 am - 9:38 am
GNV
-
TYS
3h 05m
1 stop
$447Delta
Fri, Jun 5 - Tue, Jun 9
American Airlines Logo
3:40 pm - 11:59 pm
TYS
-
GNV
8h 19m
2 stops
American Airlines Logo
7:32 pm - 11:47 pm
GNV
-
TYS
4h 15m
1 stop
$452American Airlines
Fri, Jun 5 - Tue, Jun 9
American Airlines Logo
1:00 pm - 11:59 pm
TYS
-
GNV
10h 59m
2 stops
American Airlines Logo
6:30 am - 3:15 pm
GNV
-
TYS
8h 45m
2 stops
$457American Airlines
Fri, Jun 5 - Tue, Jun 9

American Airlines flights from Knoxville to Gainesville

Our best American Airlines deals on Knoxville to Gainesville flight tickets
American Airlines
Jun 19
TYS7:59 pmKnoxville McGhee Tyson
4h 34m
1 stop
GNV12:33 amGainesville Regional
Jun 26
GNV7:32 pmGainesville Regional
4h 15m
1 stop
TYS11:47 pmKnoxville McGhee Tyson
$359
American Airlines
Jun 12
TYS1:00 pmKnoxville McGhee Tyson
10h 59m
2 stops
GNV11:59 pmGainesville Regional
Jun 14
GNV7:32 pmGainesville Regional
4h 15m
1 stop
TYS11:47 pmKnoxville McGhee Tyson
$392
American Airlines
Jun 3
TYS1:00 pmKnoxville McGhee Tyson
10h 59m
2 stops
GNV11:59 pmGainesville Regional
Aug 3
GNV7:32 pmGainesville Regional
4h 19m
1 stop
TYS11:51 pmKnoxville McGhee Tyson
$408

Delta flights from Knoxville to Gainesville

Our best Delta deals on Knoxville to Gainesville flight tickets
Delta
Jun 12
TYS5:40 amKnoxville McGhee Tyson
3h 50m
1 stop
GNV9:30 amGainesville Regional
Jun 14
GNV7:04 pmGainesville Regional
4h 50m
1 stop
TYS11:54 pmKnoxville McGhee Tyson
$387
Delta
Jun 3
TYS11:56 amKnoxville McGhee Tyson
2h 59m
1 stop
GNV2:55 pmGainesville Regional
Aug 3
GNV7:01 pmGainesville Regional
4h 51m
1 stop
TYS11:52 pmKnoxville McGhee Tyson
$403
Delta
Jun 5
TYS5:40 amKnoxville McGhee Tyson
3h 45m
1 stop
GNV9:25 amGainesville Regional
Jun 9
GNV6:33 amGainesville Regional
3h 05m
1 stop
TYS9:38 amKnoxville McGhee Tyson
$447

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Gainesville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 23, 2026.
Use the filters below to find and compare flights from Knoxville to Gainesville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Fri 6/19

7:59 pm-12:33 am

1 stop4h 34m

Gainesville Regional

Fri 6/26

7:32 pm-11:47 pm

1 stop4h 15m

$359

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Fri 6/12

5:40 am-9:30 am

1 stop3h 50m

Gainesville Regional

Sun 6/14

7:04 pm-11:54 pm

1 stop4h 50m

$387

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Fri 6/12

1:00 pm-11:59 pm

2 stops10h 59m

Gainesville Regional

Sun 6/14

7:32 pm-11:47 pm

1 stop4h 15m

$392

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Wed 6/3

11:56 am-2:55 pm

1 stop2h 59m

Gainesville Regional

Mon 8/3

7:01 pm-11:52 pm

1 stop4h 51m

$403

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Wed 6/3

1:00 pm-11:59 pm

2 stops10h 59m

Gainesville Regional

Mon 8/3

7:32 pm-11:51 pm

1 stop4h 19m

$408

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Sat 6/13

3:40 pm-11:59 pm

2 stops8h 19m

Gainesville Regional

Sun 6/14

7:32 pm-11:47 pm

1 stop4h 15m

$432

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Fri 6/19

3:40 pm-11:59 pm

2 stops8h 19m

Gainesville Regional

Fri 6/26

7:32 pm-11:47 pm

1 stop4h 15m

$433
Quickest round-trip

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Fri 6/5

5:40 am-9:25 am

1 stop3h 45m

Gainesville Regional

Tue 6/9

6:33 am-9:38 am

1 stop3h 05m

$447

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Fri 6/5

3:40 pm-11:59 pm

2 stops8h 19m

Gainesville Regional

Tue 6/9

7:32 pm-11:47 pm

1 stop4h 15m

$452

KnoxvilleGainesville

TYS - GNV

TYSGNV

Knoxville McGhee Tyson

Fri 6/5

1:00 pm-11:59 pm

2 stops10h 59m

Gainesville Regional

Tue 6/9

6:30 am-3:15 pm

2 stops8h 45m

$457

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
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See travel insights to Gainesville from

How to get the cheapest flight ticket from Knoxville to Gainesville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest Knoxville McGhee Tyson to Gainesville Regional flight route?

Fly from Knoxville McGhee Tyson to Gainesville Regional for the best Knoxville McGhee Tyson - Gainesville Regional flight prices

What cabin class options are available on Knoxville to Gainesville flights?

There is only 1 cabin class available to choose from on Knoxville to Gainesville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Knoxville to Gainesville flights?

You could potentially save up to 61% on your flight if you consider stops on a Knoxville to Gainesville flight.

When to book flights from Knoxville to Gainesville

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Gainesville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Gainesville (TYS to GNV) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Gainesville

Fastest flight time

3h 45m

Direct flights

None
The fastest flight from Knoxville to Gainesville takes 3h 45m
There are no direct flights from Knoxville to Gainesville. There are no popular flight routes from Knoxville to Gainesville.
Search flight deals

Frequently asked questions about flying from Knoxville to Gainesville

  • How far is Knoxville McGhee Tyson to Gainesville Regional by plane?

    The distance between Knoxville McGhee Tyson and Gainesville Regional is about 445.3 mi. Flights usually cover this in 3h 45m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Gainesville Regional Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Gainesville Regional Airport are updated daily.

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Gainesville Regional Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Knoxville McGhee Tyson Airport to Gainesville Regional Airport.

  • What documentation or ID do you need to fly to Gainesville Regional Airport?

    The required travel and health documents for your Gainesville Regional Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Gainesville Regional Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Gainesville?

Book flights to Gainesville if you plan to visit one of these locations
Lake City
Alachua
Trenton

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Gainesville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to Gainesville. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to Gainesville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Gainesville from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Gainesville?

momondo helps you find the best flight between Knoxville and Gainesville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Knoxville to Gainesville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Gainesville, momondo offers a useful price alert feature which will track prices for flights to Gainesville from Knoxville and alert you when they change.

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