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Cheap flights from Knoxville to Fort Myers from $150

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Fort Myers departing on 7/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Fort Myers

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
10:26 am - 2:35 pm
TYS
-
RSW
4h 09m
1 stop
Delta Logo
6:50 am - 11:05 am
RSW
-
TYS
4h 15m
1 stop
$261Delta
Wed, Aug 5 - Tue, Aug 11
American Airlines Logo
5:00 am - 9:36 am
TYS
-
RSW
4h 36m
1 stop
American Airlines Logo
7:41 pm - 11:55 pm
RSW
-
TYS
4h 14m
1 stop
$278American Airlines
Thu, May 14 - Wed, May 20
Southwest Logo
7:00 am - 5:00 pm
TYS
-
RSW
10h 00m
2 stops
Southwest Logo
2:35 pm - 6:55 pm
RSW
-
TYS
4h 20m
1 stop
$284Southwest
Wed, Aug 5 - Tue, Aug 11
American Airlines Logo
5:03 am - 9:08 am
TYS
-
RSW
4h 05m
1 stop
American Airlines Logo
6:26 am - 10:38 am
RSW
-
TYS
4h 12m
1 stop
$299American Airlines
Sat, Jul 11 - Wed, Jul 15
Delta Logo
5:40 am - 9:47 am
TYS
-
RSW
4h 07m
1 stop
Delta Logo
5:59 pm - 11:56 pm
RSW
-
TYS
5h 57m
1 stop
$311Delta
Wed, May 20 - Wed, May 20
Delta Logo
5:40 am - 9:47 am
TYS
-
RSW
4h 07m
1 stop
Delta Logo
5:35 am - 9:34 am
RSW
-
TYS
3h 59m
1 stop
$319Delta
Wed, May 20 - Sun, May 24
Southwest Logo
12:50 pm - 9:35 pm
TYS
-
RSW
8h 45m
1 stop
Southwest Logo
10:30 am - 6:30 pm
RSW
-
TYS
8h 00m
1 stop
$329Southwest
Wed, May 13 - Sat, May 23
American Airlines Logo
7:04 am - 2:12 pm
TYS
-
RSW
7h 08m
1 stop
American Airlines Logo
7:41 pm - 11:55 pm
RSW
-
TYS
4h 14m
1 stop
$331American Airlines
Tue, May 12 - Fri, May 15
Southwest Logo
7:00 am - 5:00 pm
TYS
-
RSW
10h 00m
2 stops
Southwest Logo
7:30 am - 6:55 pm
RSW
-
TYS
11h 25m
2 stops
$338Southwest
Wed, Aug 5 - Tue, Aug 11
Southwest Logo
8:05 am - 5:20 pm
TYS
-
RSW
9h 15m
1 stop
Southwest Logo
9:20 am - 8:50 pm
RSW
-
TYS
11h 30m
2 stops
$342Southwest
Thu, May 14 - Wed, May 20

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Delta flights from Knoxville to Fort Myers

Our best Delta deals on Knoxville to Fort Myers flight tickets
Delta
Aug 5
TYS10:26 amKnoxville McGhee Tyson
4h 09m
1 stop
RSW2:35 pmFort Myers SW Florida Intl
Aug 11
RSW6:50 amFort Myers SW Florida Intl
4h 15m
1 stop
TYS11:05 amKnoxville McGhee Tyson
$261
Delta
May 20
TYS5:40 amKnoxville McGhee Tyson
4h 07m
1 stop
RSW9:47 amFort Myers SW Florida Intl
May 20
RSW5:59 pmFort Myers SW Florida Intl
5h 57m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
$311
Delta
May 20
TYS5:40 amKnoxville McGhee Tyson
4h 07m
1 stop
RSW9:47 amFort Myers SW Florida Intl
May 24
RSW5:35 amFort Myers SW Florida Intl
3h 59m
1 stop
TYS9:34 amKnoxville McGhee Tyson
$319

American Airlines flights from Knoxville to Fort Myers

Our best American Airlines deals on Knoxville to Fort Myers flight tickets
American Airlines
May 14
TYS5:00 amKnoxville McGhee Tyson
4h 36m
1 stop
RSW9:36 amFort Myers SW Florida Intl
May 20
RSW7:41 pmFort Myers SW Florida Intl
4h 14m
1 stop
TYS11:55 pmKnoxville McGhee Tyson
$278
American Airlines
Jul 11
TYS5:03 amKnoxville McGhee Tyson
4h 05m
1 stop
RSW9:08 amFort Myers SW Florida Intl
Jul 15
RSW6:26 amFort Myers SW Florida Intl
4h 12m
1 stop
TYS10:38 amKnoxville McGhee Tyson
$299
American Airlines
May 12
TYS7:04 amKnoxville McGhee Tyson
7h 08m
1 stop
RSW2:12 pmFort Myers SW Florida Intl
May 15
RSW7:41 pmFort Myers SW Florida Intl
4h 14m
1 stop
TYS11:55 pmKnoxville McGhee Tyson
$331

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Fort Myers that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 21, 2026.
Use the filters below to find and compare flights from Knoxville to Fort Myers that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Wed 8/5

10:26 am-2:35 pm

1 stop4h 09m

Fort Myers SW Florida Intl

Tue 8/11

6:50 am-11:05 am

1 stop4h 15m

$261

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Thu 5/14

5:00 am-9:36 am

1 stop4h 36m

Fort Myers SW Florida Intl

Wed 5/20

7:41 pm-11:55 pm

1 stop4h 14m

$278

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Wed 8/5

7:00 am-5:00 pm

2 stops10h 00m

Fort Myers SW Florida Intl

Tue 8/11

2:35 pm-6:55 pm

1 stop4h 20m

$284

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Sat 7/11

5:03 am-9:08 am

1 stop4h 05m

Fort Myers SW Florida Intl

Wed 7/15

6:26 am-10:38 am

1 stop4h 12m

$299

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Wed 5/20

5:40 am-9:47 am

1 stop4h 07m

Fort Myers SW Florida Intl

Wed 5/20

5:59 pm-11:56 pm

1 stop5h 57m

$311
Quickest round-trip

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Wed 5/20

5:40 am-9:47 am

1 stop4h 07m

Fort Myers SW Florida Intl

Sun 5/24

5:35 am-9:34 am

1 stop3h 59m

$319

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Wed 5/13

12:50 pm-9:35 pm

1 stop8h 45m

Fort Myers SW Florida Intl

Sat 5/23

10:30 am-6:30 pm

1 stop8h 00m

$329

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Tue 5/12

7:04 am-2:12 pm

1 stop7h 08m

Fort Myers SW Florida Intl

Fri 5/15

7:41 pm-11:55 pm

1 stop4h 14m

$331

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Wed 8/5

7:00 am-5:00 pm

2 stops10h 00m

Fort Myers SW Florida Intl

Tue 8/11

7:30 am-6:55 pm

2 stops11h 25m

$338

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Thu 5/14

8:05 am-5:20 pm

1 stop9h 15m

Fort Myers SW Florida Intl

Wed 5/20

9:20 am-8:50 pm

2 stops11h 30m

$342

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Fort Myers from

How to get the cheapest flight ticket from Knoxville to Fort Myers

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Fort Myers?

What is the cheapest month to fly to Fort Myers?

In general, February is the cheapest month to fly from Knoxville to Fort Myers. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $180. If you are unable to visit Fort Myers during the month of February, then departing from Knoxville during the month August is also very affordable. Most momondo users find prices during this month for around $253.

Can stopping save me money on Knoxville to Fort Myers flights?

You could potentially save up to 7% on your flight if you consider stops on a Knoxville to Fort Myers flight.

How have Knoxville to Fort Myers flight prices changed over time?

As of April 2026, prices for Knoxville to Fort Myers flights are approximately 1% cheaper when compared to flights at the same time last year.

When to book flights from Knoxville to Fort Myers

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Fort Myers according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Fort Myers (TYS to RSW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Fort Myers

Fastest flight time

3h 55m

Direct flights

None
The fastest flight from Knoxville to Fort Myers takes 3h 55m
There are no direct flights from Knoxville to Fort Myers. There are no popular flight routes from Knoxville to Fort Myers.
Search flight deals

Frequently asked questions about flying from Knoxville to Fort Myers

  • How far is Knoxville McGhee Tyson to Fort Myers SW Florida Intl by plane?

    Fort Myers SW Florida Intl is 654.7 mi away from Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 3h 55m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Fort Myers SW Florida Intl Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Fort Myers SW Florida Intl Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Fort Myers SW Florida Intl Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Fort Myers SW Florida Intl Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Fort Myers SW Florida Intl Airport.

  • What documentation or ID do you need to fly to Fort Myers SW Florida Intl Airport?

    The required travel and health documents for your Fort Myers SW Florida Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Fort Myers SW Florida Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Fort Myers?

Best airlines flying from Knoxville to Fort Myers

Compare and see reviews for airlines that fly from Knoxville to Fort Myers with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,645 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,434 reviews
Search Delta flights

Traveling to a place near Fort Myers?

Book flights to Fort Myers if you plan to visit one of these locations
Fort Myers Beach
Sanibel
Cape Coral
Captiva
Estero
Boca Grande
North Fort Myers
Lehigh Acres

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Fort Myers?

It is quick and easy to find Knoxville to Fort Myers flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Fort Myers that suits you.

Can I find flights from Knoxville to Fort Myers with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Knoxville to Fort Myers flights to just show those with flexible booking policies.

How can momondo help me find flights from Knoxville to Fort Myers?

Once you have performed a search for Knoxville to Fort Myers flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Knoxville to Fort Myers right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Fort Myers flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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