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Cheap flights from Knoxville to Fort Myers from $135

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Fort Myers departing on 3/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Fort Myers

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
7:05 am - 2:05 pm
TYS
-
RSW
7h 00m
1 stop
Southwest Logo
7:20 am - 5:10 pm
RSW
-
TYS
9h 50m
1 stop
$254Southwest
Wed, Apr 15 - Wed, Apr 22
Southwest Logo
7:05 am - 3:40 pm
TYS
-
RSW
8h 35m
2 stops
Southwest Logo
7:20 am - 5:10 pm
RSW
-
TYS
9h 50m
1 stop
$260Southwest
Wed, Apr 15 - Wed, Apr 22
American Airlines Logo
5:00 am - 9:36 am
TYS
-
RSW
4h 36m
1 stop
American Airlines Logo
6:50 pm - 10:56 pm
RSW
-
TYS
4h 06m
1 stop
$269American Airlines
Wed, Apr 8 - Tue, Apr 14
American Airlines Logo
5:00 am - 11:31 am
TYS
-
RSW
6h 31m
1 stop
American Airlines Logo
6:50 pm - 10:56 pm
RSW
-
TYS
4h 06m
1 stop
$271American Airlines
Wed, Apr 8 - Tue, Apr 14
Southwest Logo
12:15 pm - 9:50 pm
TYS
-
RSW
9h 35m
1 stop
Southwest Logo
12:55 pm - 7:40 pm
RSW
-
TYS
6h 45m
1 stop
$275Southwest
Mon, Apr 13 - Tue, Apr 21
Southwest Logo
12:15 pm - 9:50 pm
TYS
-
RSW
9h 35m
1 stop
Southwest Logo
6:45 am - 5:10 pm
RSW
-
TYS
10h 25m
2 stops
$281Southwest
Mon, Apr 13 - Tue, Apr 21
American Airlines Logo
7:00 am - 2:12 pm
TYS
-
RSW
7h 12m
1 stop
American Airlines Logo
6:00 am - 12:45 pm
RSW
-
TYS
6h 45m
1 stop
$285American Airlines
Tue, Apr 28 - Sun, May 3
Southwest Logo
8:15 am - 8:35 pm
TYS
-
RSW
12h 20m
2 stops
Southwest Logo
12:55 pm - 8:50 pm
RSW
-
TYS
7h 55m
2 stops
$294Southwest
Wed, Apr 15 - Wed, Apr 22
Multiple Airlines Logo
6:00 am - 6:19 pm
TYS
-
RSW
12h 19m
1 stop
Multiple Airlines Logo
11:12 am - 10:36 am
RSW
-
TYS
47h 24m
2 stops
$297Multiple Airlines
Sun, Apr 12 - Mon, Apr 20
American Airlines Logo
5:00 am - 9:36 am
TYS
-
RSW
4h 36m
1 stop
American Airlines Logo
6:00 am - 12:45 pm
RSW
-
TYS
6h 45m
1 stop
$299American Airlines
Fri, May 1 - Sun, May 3

American Airlines flights from Knoxville to Fort Myers

Our best American Airlines deals on Knoxville to Fort Myers flight tickets
American Airlines
Apr 8
TYS5:00 amKnoxville McGhee Tyson
4h 36m
1 stop
RSW9:36 amFort Myers SW Florida Intl
Apr 14
RSW6:50 pmFort Myers SW Florida Intl
4h 06m
1 stop
TYS10:56 pmKnoxville McGhee Tyson
$269
American Airlines
Apr 8
TYS5:00 amKnoxville McGhee Tyson
6h 31m
1 stop
RSW11:31 amFort Myers SW Florida Intl
Apr 14
RSW6:50 pmFort Myers SW Florida Intl
4h 06m
1 stop
TYS10:56 pmKnoxville McGhee Tyson
$271
American Airlines
Apr 28
TYS7:00 amKnoxville McGhee Tyson
7h 12m
1 stop
RSW2:12 pmFort Myers SW Florida Intl
May 3
RSW6:00 amFort Myers SW Florida Intl
6h 45m
1 stop
TYS12:45 pmKnoxville McGhee Tyson
$285

Southwest flights from Knoxville to Fort Myers

Our best Southwest deals on Knoxville to Fort Myers flight tickets
Southwest
Apr 15
TYS7:05 amKnoxville McGhee Tyson
7h 00m
1 stop
RSW2:05 pmFort Myers SW Florida Intl
Apr 22
RSW7:20 amFort Myers SW Florida Intl
9h 50m
1 stop
TYS5:10 pmKnoxville McGhee Tyson
$254
Southwest
Apr 15
TYS7:05 amKnoxville McGhee Tyson
8h 35m
2 stops
RSW3:40 pmFort Myers SW Florida Intl
Apr 22
RSW7:20 amFort Myers SW Florida Intl
9h 50m
1 stop
TYS5:10 pmKnoxville McGhee Tyson
$260
Southwest
Apr 13
TYS12:15 pmKnoxville McGhee Tyson
9h 35m
1 stop
RSW9:50 pmFort Myers SW Florida Intl
Apr 21
RSW12:55 pmFort Myers SW Florida Intl
6h 45m
1 stop
TYS7:40 pmKnoxville McGhee Tyson
$275

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Fort Myers that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 8, 2026.
Use the filters below to find and compare flights from Knoxville to Fort Myers that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Wed 4/15

7:05 am-2:05 pm

1 stop7h 00m

Fort Myers SW Florida Intl

Wed 4/22

7:20 am-5:10 pm

1 stop9h 50m

$254

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Wed 4/15

7:05 am-3:40 pm

2 stops8h 35m

Fort Myers SW Florida Intl

Wed 4/22

7:20 am-5:10 pm

1 stop9h 50m

$260
Quickest round-trip

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Wed 4/8

5:00 am-9:36 am

1 stop4h 36m

Fort Myers SW Florida Intl

Tue 4/14

6:50 pm-10:56 pm

1 stop4h 06m

$269

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Wed 4/8

5:00 am-11:31 am

1 stop6h 31m

Fort Myers SW Florida Intl

Tue 4/14

6:50 pm-10:56 pm

1 stop4h 06m

$271

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Mon 4/13

12:15 pm-9:50 pm

1 stop9h 35m

Fort Myers SW Florida Intl

Tue 4/21

12:55 pm-7:40 pm

1 stop6h 45m

$275

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Mon 4/13

12:15 pm-9:50 pm

1 stop9h 35m

Fort Myers SW Florida Intl

Tue 4/21

6:45 am-5:10 pm

2 stops10h 25m

$281

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Tue 4/28

7:00 am-2:12 pm

1 stop7h 12m

Fort Myers SW Florida Intl

Sun 5/3

6:00 am-12:45 pm

1 stop6h 45m

$285

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Wed 4/15

8:15 am-8:35 pm

2 stops12h 20m

Fort Myers SW Florida Intl

Wed 4/22

12:55 pm-8:50 pm

2 stops7h 55m

$294

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Sun 4/12

6:00 am-6:19 pm

1 stop12h 19m

Fort Myers SW Florida Intl

Mon 4/20

11:12 am-10:36 am

2 stops47h 24m

$297

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Fri 5/1

5:00 am-9:36 am

1 stop4h 36m

Fort Myers SW Florida Intl

Sun 5/3

6:00 am-12:45 pm

1 stop6h 45m

$299

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Fort Myers from

How to get the cheapest flight ticket from Knoxville to Fort Myers

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Fort Myers?

In general, February is the cheapest month to fly from Knoxville to Fort Myers. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $180. If you are unable to visit Fort Myers during the month of February, then departing from Knoxville during the month August is also very affordable. Most momondo users find prices during this month for around $253.

Can stopping save me money on Knoxville to Fort Myers flights?

You could potentially save up to 7% on your flight if you consider stops on a Knoxville to Fort Myers flight.

How have Knoxville to Fort Myers flight prices changed over time?

As of March 2026, prices for Knoxville to Fort Myers flights are approximately 157% more expensive when compared to flights at the same time last year.

When to book flights from Knoxville to Fort Myers

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Fort Myers according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Fort Myers (TYS to RSW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Fort Myers

Fastest flight time

3h 32m

Direct flights

None
The fastest flight from Knoxville to Fort Myers takes 3h 32m
There are no direct flights from Knoxville to Fort Myers. There are no popular flight routes from Knoxville to Fort Myers.
Search flight deals

  • How far is Knoxville McGhee Tyson to Fort Myers SW Florida Intl by plane?

    Fort Myers SW Florida Intl is 654.7 mi away from Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 3h 32m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Fort Myers SW Florida Intl Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Fort Myers SW Florida Intl Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Fort Myers SW Florida Intl Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Fort Myers SW Florida Intl Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Fort Myers SW Florida Intl Airport.

  • What documentation or ID do you need to fly to Fort Myers SW Florida Intl Airport?

    The required travel and health documents for your Fort Myers SW Florida Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Fort Myers SW Florida Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Fort Myers?

Best airlines flying from Knoxville to Fort Myers

Compare and see reviews for airlines that fly from Knoxville to Fort Myers with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $223Free CancellationRating
7.9
8,269 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,397 reviews
Search American Airlines flights

Traveling to a place near Fort Myers?

Book flights to Fort Myers if you plan to visit one of these locations
Fort Myers Beach
Sanibel
Cape Coral
Captiva
Estero
Boca Grande
North Fort Myers
Lehigh Acres

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Fort Myers?

It is quick and easy to find Knoxville to Fort Myers flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Fort Myers that suits you.

Can I find flights from Knoxville to Fort Myers with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Knoxville to Fort Myers flights to just show those with flexible booking policies.

How can momondo help me find flights from Knoxville to Fort Myers?

Once you have performed a search for Knoxville to Fort Myers flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Knoxville to Fort Myers right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Fort Myers flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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