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Cheap flights from Knoxville to Fort Myers from $150

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Fort Myers departing on 5/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Fort Myers

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
2:53 pm - 8:45 pm
TYS
-
RSW
5h 52m1 stop
American Airlines Logo
7:16 am - 11:52 am
RSW
-
TYS
4h 36m1 stop
$227American Airlines
Sat, Feb 21 - Tue, Feb 24
American Airlines Logo
2:53 pm - 8:45 pm
TYS
-
RSW
5h 52m1 stop
American Airlines Logo
6:00 am - 11:17 am
RSW
-
TYS
5h 17m1 stop
$237American Airlines
Sat, Feb 21 - Sat, Feb 28
American Airlines Logo
5:57 pm - 12:28 am
TYS
-
RSW
6h 31m1 stop
American Airlines Logo
5:47 pm - 10:54 pm
RSW
-
TYS
5h 07m1 stop
$258American Airlines
Fri, Feb 13 - Tue, Feb 17
American Airlines Logo
7:00 am - 1:03 pm
TYS
-
RSW
6h 03m1 stop
American Airlines Logo
7:47 pm - 11:54 pm
RSW
-
TYS
4h 07m1 stop
$268American Airlines
Mon, Feb 23 - Fri, Feb 27
Multiple Airlines Logo
12:55 pm - 11:01 am
TYS
-
RSW
22h 06m2 stops
Multiple Airlines Logo
7:31 am - 11:09 am
RSW
-
TYS
27h 38m2 stops
$272Multiple Airlines
Fri, Jan 23 - Fri, Jan 30
Multiple Airlines Logo
8:30 am - 8:00 pm
TYS
-
RSW
35h 30m3 stops
Multiple Airlines Logo
7:31 am - 11:09 am
RSW
-
TYS
27h 38m2 stops
$288Multiple Airlines
Fri, Jan 23 - Fri, Jan 30
American Airlines Logo
2:50 pm - 8:45 pm
TYS
-
RSW
5h 55m1 stop
American Airlines Logo
7:47 pm - 11:54 pm
RSW
-
TYS
4h 07m1 stop
$299American Airlines
Fri, Feb 20 - Mon, Feb 23
Multiple Airlines Logo
8:30 am - 8:00 pm
TYS
-
RSW
35h 30m3 stops
Multiple Airlines Logo
2:34 pm - 5:09 pm
RSW
-
TYS
26h 35m3 stops
$309Multiple Airlines
Fri, Jan 23 - Fri, Jan 30
American Airlines Logo
5:14 pm - 11:33 pm
TYS
-
RSW
6h 19m1 stop
American Airlines Logo
6:35 pm - 10:54 pm
RSW
-
TYS
4h 19m1 stop
$327American Airlines
Sun, Jan 11 - Thu, Jan 22
Delta Logo
6:41 pm - 12:32 am
TYS
-
RSW
5h 51m1 stop
Delta Logo
6:35 am - 11:08 am
RSW
-
TYS
4h 33m1 stop
$338Delta
Fri, Jan 23 - Fri, Jan 30

Southwest flights from Knoxville to Fort Myers

Our best Southwest deals on Knoxville to Fort Myers flight tickets
Southwest
Mar 23
TYS1:20 pmKnoxville McGhee Tyson
8h 35m
1 stop
RSW9:55 pmFort Myers SW Florida Intl
Mar 28
RSW2:40 pmFort Myers SW Florida Intl
7h 30m
1 stop
TYS10:10 pmKnoxville McGhee Tyson
$358
Find similar
Southwest
Mar 8
TYS7:40 amKnoxville McGhee Tyson
12h 15m
1 stop
RSW7:55 pmFort Myers SW Florida Intl
Mar 11
RSW10:20 amFort Myers SW Florida Intl
10h 50m
2 stops
TYS9:10 pmKnoxville McGhee Tyson
$378
Find similar
Southwest
Apr 11
TYS6:40 amKnoxville McGhee Tyson
12h 05m
2 stops
RSW6:45 pmFort Myers SW Florida Intl
Apr 19
RSW8:25 amFort Myers SW Florida Intl
10h 35m
2 stops
TYS7:00 pmKnoxville McGhee Tyson
$383
Find similar

American Airlines flights from Knoxville to Fort Myers

Our best American Airlines deals on Knoxville to Fort Myers flight tickets
American Airlines
Feb 21
TYS2:53 pmKnoxville McGhee Tyson
5h 52m
1 stop
RSW8:45 pmFort Myers SW Florida Intl
Feb 24
RSW7:16 amFort Myers SW Florida Intl
4h 36m
1 stop
TYS11:52 amKnoxville McGhee Tyson
$227
Find similar
American Airlines
Feb 21
TYS2:53 pmKnoxville McGhee Tyson
5h 52m
1 stop
RSW8:45 pmFort Myers SW Florida Intl
Feb 28
RSW6:00 amFort Myers SW Florida Intl
5h 17m
1 stop
TYS11:17 amKnoxville McGhee Tyson
$237
Find similar
American Airlines
Feb 13
TYS5:57 pmKnoxville McGhee Tyson
6h 31m
1 stop
RSW12:28 amFort Myers SW Florida Intl
Feb 17
RSW5:47 pmFort Myers SW Florida Intl
5h 07m
1 stop
TYS10:54 pmKnoxville McGhee Tyson
$258
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Fort Myers that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 28, 2025.
Use the filters below to find and compare flights from Knoxville to Fort Myers that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Sat 2/21

2:53 pm-8:45 pm

1 stop5h 52m

Fort Myers SW Florida Intl

Tue 2/24

7:16 am-11:52 am

1 stop4h 36m

$227

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Sat 2/21

2:53 pm-8:45 pm

1 stop5h 52m

Fort Myers SW Florida Intl

Sat 2/28

6:00 am-11:17 am

1 stop5h 17m

$237

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Fri 2/13

5:57 pm-12:28 am

1 stop6h 31m

Fort Myers SW Florida Intl

Tue 2/17

5:47 pm-10:54 pm

1 stop5h 07m

$258

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Mon 2/23

7:00 am-1:03 pm

1 stop6h 03m

Fort Myers SW Florida Intl

Fri 2/27

7:47 pm-11:54 pm

1 stop4h 07m

$268

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Fri 1/23

12:55 pm-11:01 am

2 stops22h 06m

Fort Myers SW Florida Intl

Fri 1/30

7:31 am-11:09 am

2 stops27h 38m

$272

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Fri 1/23

8:30 am-8:00 pm

3 stops35h 30m

Fort Myers SW Florida Intl

Fri 1/30

7:31 am-11:09 am

2 stops27h 38m

$288

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Fri 2/20

2:50 pm-8:45 pm

1 stop5h 55m

Fort Myers SW Florida Intl

Mon 2/23

7:47 pm-11:54 pm

1 stop4h 07m

$299

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Fri 1/23

8:30 am-8:00 pm

3 stops35h 30m

Fort Myers SW Florida Intl

Fri 1/30

2:34 pm-5:09 pm

3 stops26h 35m

$309

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Sun 1/11

5:14 pm-11:33 pm

1 stop6h 19m

Fort Myers SW Florida Intl

Thu 1/22

6:35 pm-10:54 pm

1 stop4h 19m

$327

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Fri 1/23

6:41 pm-12:32 am

1 stop5h 51m

Fort Myers SW Florida Intl

Fri 1/30

6:35 am-11:08 am

1 stop4h 33m

$338

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Fort Myers from

How to get the cheapest flight ticket from Knoxville to Fort Myers

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Fort Myers?

In general, August is the cheapest month to fly from Knoxville to Fort Myers. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $253. If you are unable to visit Fort Myers during the month of August, then departing from Knoxville during the month February is also very affordable. Most momondo users find prices during this month for around $268.

What is the cheapest day to depart on your flight to Fort Myers?

The cheapest day to depart from Knoxville to Fort Myers is on a Wednesday when prices can be found for as low as $283. Flights from Knoxville to Fort Myers on a Sunday will generally be more expensive and average around $496. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Fort Myers?

The cheapest time of day to fly to Fort Myers is in the evening when flights can be purchased for as low as $286. Flights in the morning are often more expensive with an average ticket price of $358.

Can stopping save me money on Knoxville to Fort Myers flights?

You could potentially save up to 35% on your flight if you consider stops on a Knoxville to Fort Myers flight.

When to book flights from Knoxville to Fort Myers

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Fort Myers according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Fort Myers (TYS to RSW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Fort Myers

Fastest flight time

3h 46m

Direct flights

None
The fastest flight from Knoxville to Fort Myers takes 3h 46m
There are no direct flights from Knoxville to Fort Myers. There are no popular flight routes from Knoxville to Fort Myers.
Search flight deals

  • How far is Knoxville McGhee Tyson to Fort Myers SW Florida Intl by plane?

    Fort Myers SW Florida Intl is 654.7 mi away from Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 3h 46m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Fort Myers SW Florida Intl Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Fort Myers SW Florida Intl Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Fort Myers SW Florida Intl Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Fort Myers SW Florida Intl Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Fort Myers SW Florida Intl Airport.

  • What documentation or ID do you need to fly to Fort Myers SW Florida Intl Airport?

    The required travel and health documents for your Fort Myers SW Florida Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Fort Myers SW Florida Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Fort Myers?

Best airlines flying from Knoxville to Fort Myers

Compare and see reviews for airlines that fly from Knoxville to Fort Myers with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $223Free CancellationRating
7.9
8,019 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,072 reviews
Search American Airlines flights

Traveling to a place near Fort Myers?

Book flights to Fort Myers if you plan to visit one of these locations
Fort Myers Beach
Sanibel
Cape Coral
Captiva
Estero
Boca Grande
North Fort Myers
Lehigh Acres

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Fort Myers?

It is quick and easy to find Knoxville to Fort Myers flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Fort Myers that suits you.

Can I find flights from Knoxville to Fort Myers with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Knoxville to Fort Myers flights to just show those with flexible booking policies.

How can momondo help me find flights from Knoxville to Fort Myers?

Once you have performed a search for Knoxville to Fort Myers flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Knoxville to Fort Myers right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Fort Myers flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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