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Cheap flights from Knoxville to Fort Myers from $150

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Fort Myers departing on 12/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to Fort Myers

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
3:57 pm - 9:33 pmTYS-RSW
5h 36m1 stop
Delta Logo
4:12 pm - 8:05 pmRSW-TYS
3h 53m1 stop
$259Delta
Find Deal
Wed, Dec 3 - Wed, Dec 10
Delta Logo
8:35 am - 12:32 pmTYS-RSW
3h 57m1 stop
Delta Logo
5:38 pm - 11:28 pmRSW-TYS
5h 50m1 stop
$279Delta
Find Deal
Sat, Dec 6 - Mon, Dec 8
American Airlines Logo
8:07 am - 2:06 pmTYS-RSW
5h 59m1 stop
American Airlines Logo
4:03 pm - 9:22 pmRSW-TYS
5h 19m1 stop
$314American Airlines
Find Deal
Tue, Nov 11 - Mon, Dec 8
United Airlines Logo
1:59 pm - 8:12 pmTYS-RSW
6h 13m1 stop
United Airlines Logo
9:00 am - 9:02 pmRSW-TYS
12h 02m2 stops
$334United Airlines
Find Deal
Wed, Jan 7 - Sat, Jan 10
United Airlines Logo
11:10 am - 9:59 pmTYS-RSW
10h 49m2 stops
United Airlines Logo
9:00 am - 9:02 pmRSW-TYS
12h 02m2 stops
$339United Airlines
Find Deal
Wed, Jan 7 - Sat, Jan 10
Southwest Logo
7:50 am - 4:25 pmTYS-RSW
8h 35m1 stop
Southwest Logo
5:05 pm - 10:10 pmRSW-TYS
5h 05m1 stop
$343Southwest
Find Deal
Mon, Mar 16 - Fri, Mar 20
Multiple Airlines Logo
11:24 am - 2:18 pmTYS-RSW
26h 54m3 stops
Multiple Airlines Logo
6:25 am - 9:49 pmRSW-TYS
15h 24m2 stops
$367Multiple Airlines
Find Deal
Tue, Nov 11 - Mon, Dec 8
Southwest Logo
1:20 pm - 9:55 pmTYS-RSW
8h 35m1 stop
Southwest Logo
6:15 am - 12:45 pmRSW-TYS
6h 30m2 stops
$369Southwest
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Mon, Mar 16 - Fri, Mar 20
American Airlines Logo
12:17 pm - 5:45 pmTYS-RSW
5h 28m1 stop
American Airlines Logo
7:51 pm - 11:41 pmRSW-TYS
3h 50m1 stop
$376American Airlines
Find Deal
Wed, Feb 11 - Tue, Feb 17
Multiple Airlines Logo
11:24 am - 2:18 pmTYS-RSW
26h 54m3 stops
Multiple Airlines Logo
6:25 am - 9:49 pmRSW-TYS
15h 24m3 stops
$393Multiple Airlines
Find Deal
Tue, Nov 11 - Mon, Dec 8

American Airlines flights from Knoxville to Fort Myers

Our best American Airlines deals on Knoxville to Fort Myers flight tickets
American Airlines
Nov 11
TYS8:07 amKnoxville McGhee Tyson
5h 59m
1 stop
RSW2:06 pmFort Myers SW Florida Intl
Dec 8
RSW4:03 pmFort Myers SW Florida Intl
5h 19m
1 stop
TYS9:22 pmKnoxville McGhee Tyson
$314
Find similar
American Airlines
Feb 11
TYS12:17 pmKnoxville McGhee Tyson
5h 28m
1 stop
RSW5:45 pmFort Myers SW Florida Intl
Feb 17
RSW7:51 pmFort Myers SW Florida Intl
3h 50m
1 stop
TYS11:41 pmKnoxville McGhee Tyson
$376
Find similar
American Airlines
Nov 16
TYS8:04 pmKnoxville McGhee Tyson
4h 23m
1 stop
RSW12:27 amFort Myers SW Florida Intl
Nov 23
RSW6:13 amFort Myers SW Florida Intl
4h 06m
1 stop
TYS10:19 amKnoxville McGhee Tyson
$426
Find similar

Delta flights from Knoxville to Fort Myers

Our best Delta deals on Knoxville to Fort Myers flight tickets
Delta
Dec 3
TYS3:57 pmKnoxville McGhee Tyson
5h 36m
1 stop
RSW9:33 pmFort Myers SW Florida Intl
Dec 10
RSW4:12 pmFort Myers SW Florida Intl
3h 53m
1 stop
TYS8:05 pmKnoxville McGhee Tyson
$259
Find similar
Delta
Dec 6
TYS8:35 amKnoxville McGhee Tyson
3h 57m
1 stop
RSW12:32 pmFort Myers SW Florida Intl
Dec 8
RSW5:38 pmFort Myers SW Florida Intl
5h 50m
1 stop
TYS11:28 pmKnoxville McGhee Tyson
$279
Find similar
Delta
Mar 10
TYS5:30 amKnoxville McGhee Tyson
4h 32m
1 stop
RSW10:02 amFort Myers SW Florida Intl
Mar 11
RSW5:35 amFort Myers SW Florida Intl
3h 38m
1 stop
TYS9:13 amKnoxville McGhee Tyson
$299
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Fort Myers that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 20, 2025.
Use the filters below to find and compare flights from Knoxville to Fort Myers that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Wed 12/3

3:57 pm-9:33 pm

1 stop5h 36m

Fort Myers SW Florida Intl

Wed 12/10

4:12 pm-8:05 pm

1 stop3h 53m

$259

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Sat 12/6

8:35 am-12:32 pm

1 stop3h 57m

Fort Myers SW Florida Intl

Mon 12/8

5:38 pm-11:28 pm

1 stop5h 50m

$279

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Tue 11/11

8:07 am-2:06 pm

1 stop5h 59m

Fort Myers SW Florida Intl

Mon 12/8

4:03 pm-9:22 pm

1 stop5h 19m

$314

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Wed 1/7

1:59 pm-8:12 pm

1 stop6h 13m

Fort Myers SW Florida Intl

Sat 1/10

9:00 am-9:02 pm

2 stops12h 02m

$334

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Wed 1/7

11:10 am-9:59 pm

2 stops10h 49m

Fort Myers SW Florida Intl

Sat 1/10

9:00 am-9:02 pm

2 stops12h 02m

$339

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Mon 3/16

7:50 am-4:25 pm

1 stop8h 35m

Fort Myers SW Florida Intl

Fri 3/20

5:05 pm-10:10 pm

1 stop5h 05m

$343

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Tue 11/11

11:24 am-2:18 pm

3 stops26h 54m

Fort Myers SW Florida Intl

Mon 12/8

6:25 am-9:49 pm

2 stops15h 24m

$367

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Mon 3/16

1:20 pm-9:55 pm

1 stop8h 35m

Fort Myers SW Florida Intl

Fri 3/20

6:15 am-12:45 pm

2 stops6h 30m

$369

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Wed 2/11

12:17 pm-5:45 pm

1 stop5h 28m

Fort Myers SW Florida Intl

Tue 2/17

7:51 pm-11:41 pm

1 stop3h 50m

$376

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Tue 11/11

11:24 am-2:18 pm

3 stops26h 54m

Fort Myers SW Florida Intl

Mon 12/8

6:25 am-9:49 pm

3 stops15h 24m

$393

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Fort Myers from

How to get the cheapest flight ticket from Knoxville to Fort Myers

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Fort Myers?

In general, August is the cheapest month to fly from Knoxville to Fort Myers. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $253. If you are unable to visit Fort Myers during the month of August, then departing from Knoxville during the month January is also very affordable. Most momondo users find prices during this month for around $283.

What is the cheapest day to depart on your flight to Fort Myers?

The cheapest day to depart from Knoxville to Fort Myers is on a Wednesday when prices can be found for as low as $283. Flights from Knoxville to Fort Myers on a Sunday will generally be more expensive and average around $496. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Fort Myers?

The cheapest time of day to fly to Fort Myers is in the evening when flights can be purchased for as low as $286. Flights in the morning are often more expensive with an average ticket price of $358.

Can stopping save me money on Knoxville to Fort Myers flights?

You could potentially save up to 35% on your flight if you consider stops on a Knoxville to Fort Myers flight.

When to book flights from Knoxville to Fort Myers

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Fort Myers according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Fort Myers (TYS to RSW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Fort Myers

Direct flights

None
There are no direct flights from Knoxville to Fort Myers. There are no popular flight routes from Knoxville to Fort Myers.
Search flight deals

  • How far is Knoxville McGhee Tyson to Fort Myers SW Florida Intl by plane?

    Fort Myers SW Florida Intl is 654.7 mi away from Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 3h 57m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Fort Myers SW Florida Intl Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Fort Myers SW Florida Intl Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Fort Myers SW Florida Intl Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Fort Myers SW Florida Intl Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Fort Myers SW Florida Intl Airport.

  • What documentation or ID do you need to fly to Fort Myers SW Florida Intl Airport?

    The required travel and health documents for your Fort Myers SW Florida Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Fort Myers SW Florida Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Fort Myers?

Best airlines flying from Knoxville to Fort Myers

Compare and see reviews for airlines that fly from Knoxville to Fort Myers with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $223Free CancellationRating
7.9
7,978 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,024 reviews
Search American Airlines flights

Traveling to a place near Fort Myers?

Book flights to Fort Myers if you plan to visit one of these locations
Fort Myers Beach
Sanibel
Cape Coral
Captiva
Estero
North Fort Myers
Boca Grande
Lehigh Acres

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Fort Myers?

It is quick and easy to find Knoxville to Fort Myers flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Fort Myers that suits you.

Can I find flights from Knoxville to Fort Myers with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Knoxville to Fort Myers flights to just show those with flexible booking policies.

How can momondo help me find flights from Knoxville to Fort Myers?

Once you have performed a search for Knoxville to Fort Myers flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Knoxville to Fort Myers right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Fort Myers flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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