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Cheap flights from Knoxville to Fort Myers from $126

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Fort Myers departing on 8/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Fort Myers

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
8:10 am - 2:08 pm
TYS
-
RSW
5h 58m
1 stop
American Airlines Logo
7:20 am - 1:31 pm
RSW
-
TYS
6h 11m
1 stop
$251American Airlines
Tue, Aug 18 - Tue, Aug 25
Southwest Logo
7:00 am - 5:00 pm
TYS
-
RSW
10h 00m
2 stops
Southwest Logo
7:20 am - 1:05 pm
RSW
-
TYS
5h 45m
1 stop
$256Southwest
Tue, Aug 18 - Tue, Aug 25
Southwest Logo
7:00 am - 5:00 pm
TYS
-
RSW
10h 00m
2 stops
Southwest Logo
7:30 am - 6:55 pm
RSW
-
TYS
11h 25m
2 stops
$261Southwest
Tue, Aug 18 - Tue, Aug 25
Southwest Logo
8:05 am - 7:50 pm
TYS
-
RSW
11h 45m
2 stops
Southwest Logo
11:35 am - 5:50 pm
RSW
-
TYS
6h 15m
1 stop
$304Southwest
Tue, Sep 29 - Sat, Oct 3
Delta Logo
5:45 am - 9:49 am
TYS
-
RSW
4h 04m
1 stop
Delta Logo
7:50 pm - 11:59 pm
RSW
-
TYS
4h 09m
1 stop
$307Delta
Wed, Oct 14 - Mon, Oct 19
Southwest Logo
7:15 am - 5:05 pm
TYS
-
RSW
9h 50m
2 stops
Southwest Logo
7:15 am - 1:10 pm
RSW
-
TYS
5h 55m
1 stop
$309Southwest
Wed, Oct 14 - Mon, Oct 19
Delta Logo
12:01 pm - 4:44 pm
TYS
-
RSW
4h 43m
1 stop
Delta Logo
8:09 am - 12:28 pm
RSW
-
TYS
4h 19m
1 stop
$314Delta
Fri, Sep 4 - Sun, Sep 6
Delta Logo
5:45 am - 9:49 am
TYS
-
RSW
4h 04m
1 stop
Delta Logo
7:50 pm - 11:59 pm
RSW
-
TYS
4h 09m
1 stop
$317Delta
Wed, Oct 14 - Mon, Oct 19
American Airlines Logo
5:15 am - 10:14 am
TYS
-
RSW
4h 59m
1 stop
American Airlines Logo
8:00 am - 3:13 pm
RSW
-
TYS
7h 13m
1 stop
$319American Airlines
Fri, Aug 21 - Sun, Aug 23
Delta Logo
6:12 pm - 12:40 am
TYS
-
RSW
6h 28m
1 stop
Delta Logo
5:35 am - 9:36 am
RSW
-
TYS
4h 01m
1 stop
$325Delta
Mon, Aug 31 - Mon, Sep 7

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Delta flights from Knoxville to Fort Myers

Our best Delta deals on Knoxville to Fort Myers flight tickets
Delta
Oct 14
TYS5:45 amKnoxville McGhee Tyson
4h 04m
1 stop
RSW9:49 amFort Myers SW Florida Intl
Oct 19
RSW7:50 pmFort Myers SW Florida Intl
4h 09m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
$269
Delta
Aug 15
TYS5:00 pmKnoxville McGhee Tyson
4h 18m
1 stop
RSW9:18 pmFort Myers SW Florida Intl
Sep 17
RSW5:30 amFort Myers SW Florida Intl
3h 59m
1 stop
TYS9:29 amKnoxville McGhee Tyson
$283
Delta
Oct 14
TYS5:45 amKnoxville McGhee Tyson
4h 04m
1 stop
RSW9:49 amFort Myers SW Florida Intl
Oct 19
RSW7:50 pmFort Myers SW Florida Intl
4h 09m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
$307

American Airlines flights from Knoxville to Fort Myers

Our best American Airlines deals on Knoxville to Fort Myers flight tickets
American Airlines
Aug 18
TYS8:10 amKnoxville McGhee Tyson
5h 58m
1 stop
RSW2:08 pmFort Myers SW Florida Intl
Aug 25
RSW7:20 amFort Myers SW Florida Intl
6h 11m
1 stop
TYS1:31 pmKnoxville McGhee Tyson
$251
American Airlines
Aug 21
TYS5:15 amKnoxville McGhee Tyson
4h 59m
1 stop
RSW10:14 amFort Myers SW Florida Intl
Aug 23
RSW8:00 amFort Myers SW Florida Intl
7h 13m
1 stop
TYS3:13 pmKnoxville McGhee Tyson
$319
American Airlines
Aug 21
TYS12:09 pmKnoxville McGhee Tyson
5h 32m
1 stop
RSW5:41 pmFort Myers SW Florida Intl
Aug 28
RSW3:02 pmFort Myers SW Florida Intl
5h 57m
1 stop
TYS8:59 pmKnoxville McGhee Tyson
$329

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Fort Myers that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 23, 2026.
Use the filters below to find and compare flights from Knoxville to Fort Myers that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Tue 8/18

8:10 am-2:08 pm

1 stop5h 58m

Fort Myers SW Florida Intl

Tue 8/25

7:20 am-1:31 pm

1 stop6h 11m

$251

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Tue 8/18

7:00 am-5:00 pm

2 stops10h 00m

Fort Myers SW Florida Intl

Tue 8/25

7:20 am-1:05 pm

1 stop5h 45m

$256

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Tue 8/18

7:00 am-5:00 pm

2 stops10h 00m

Fort Myers SW Florida Intl

Tue 8/25

7:30 am-6:55 pm

2 stops11h 25m

$261

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Tue 9/29

8:05 am-7:50 pm

2 stops11h 45m

Fort Myers SW Florida Intl

Sat 10/3

11:35 am-5:50 pm

1 stop6h 15m

$304
Quickest round-trip

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Wed 10/14

5:45 am-9:49 am

1 stop4h 04m

Fort Myers SW Florida Intl

Mon 10/19

7:50 pm-11:59 pm

1 stop4h 09m

$307

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Wed 10/14

7:15 am-5:05 pm

2 stops9h 50m

Fort Myers SW Florida Intl

Mon 10/19

7:15 am-1:10 pm

1 stop5h 55m

$309

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Fri 9/4

12:01 pm-4:44 pm

1 stop4h 43m

Fort Myers SW Florida Intl

Sun 9/6

8:09 am-12:28 pm

1 stop4h 19m

$314

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Wed 10/14

5:45 am-9:49 am

1 stop4h 04m

Fort Myers SW Florida Intl

Mon 10/19

7:50 pm-11:59 pm

1 stop4h 09m

$317

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Fri 8/21

5:15 am-10:14 am

1 stop4h 59m

Fort Myers SW Florida Intl

Sun 8/23

8:00 am-3:13 pm

1 stop7h 13m

$319

KnoxvilleFort Myers

TYS - RSW

TYSRSW

Knoxville McGhee Tyson

Mon 8/31

6:12 pm-12:40 am

1 stop6h 28m

Fort Myers SW Florida Intl

Mon 9/7

5:35 am-9:36 am

1 stop4h 01m

$325

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Fort Myers from

How to get the cheapest flight ticket from Knoxville to Fort Myers

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Fort Myers?

Prices are currently low for flights on this route.

Typical prices usually range from $268 to $368.
The lowest price recently found on this route was $251.

What is the cheapest month to fly to Fort Myers?

In general, February is the cheapest month to fly from Knoxville to Fort Myers. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $236. If you are unable to visit Fort Myers during the month of February, then departing from Knoxville during the month July is also very affordable. Most momondo users find prices during this month for around $330.

Can stopping save me money on Knoxville to Fort Myers flights?

You could potentially save up to 6% on your flight if you consider stops on a Knoxville to Fort Myers flight.

How have Knoxville to Fort Myers flight prices changed over time?

As of July 2026, prices for Knoxville to Fort Myers flights are approximately 167% more expensive when compared to flights at the same time last year.

When to book flights from Knoxville to Fort Myers

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Fort Myers according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Fort Myers (TYS to RSW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Fort Myers

Fastest flight time

4h 04m

Direct flights

None
The fastest flight from Knoxville to Fort Myers takes 4h 04m
There are no direct flights from Knoxville to Fort Myers. There are no popular flight routes from Knoxville to Fort Myers.
Search flight deals

Frequently asked questions about flying from Knoxville to Fort Myers

  • How far is Knoxville McGhee Tyson to Fort Myers SW Florida Intl by plane?

    Fort Myers SW Florida Intl is 654.7 mi away from Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 4h 04m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Fort Myers SW Florida Intl Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Fort Myers SW Florida Intl Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Fort Myers SW Florida Intl Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Fort Myers SW Florida Intl Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Fort Myers SW Florida Intl Airport.

  • What documentation or ID do you need to fly to Fort Myers SW Florida Intl Airport?

    The required travel and health documents for your Fort Myers SW Florida Intl Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Fort Myers SW Florida Intl Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Fort Myers?

Best airlines flying from Knoxville to Fort Myers

Compare and see reviews for airlines that fly from Knoxville to Fort Myers with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,832 reviews
Search American Airlines flights
DeltaPriceFrom $253Free CancellationRating
7.8
8,479 reviews
Search Delta flights

Traveling to a place near Fort Myers?

Book flights to Fort Myers if you plan to visit one of these locations
Fort Myers Beach
Sanibel
Cape Coral
Captiva
Estero
Lehigh Acres
Boca Grande
North Fort Myers

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Fort Myers?

It is quick and easy to find Knoxville to Fort Myers flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Fort Myers that suits you.

Can I find flights from Knoxville to Fort Myers with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Knoxville to Fort Myers flights to just show those with flexible booking policies.

How can momondo help me find flights from Knoxville to Fort Myers?

Once you have performed a search for Knoxville to Fort Myers flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Knoxville to Fort Myers right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Knoxville to Fort Myers flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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