Cheap flights from Knoxville to Florida Keys from $65

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Florida Keys departing on 4/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
8:00 am - 10:11 am
TYS
-
EYW
2h 11mnonstop
Allegiant Air Logo
11:01 am - 1:16 pm
EYW
-
TYS
2h 15mnonstop
$65Allegiant Air
Mon, Apr 27 - Fri, May 1
Allegiant Air Logo
8:00 am - 10:11 am
TYS
-
EYW
2h 11mnonstop
Allegiant Air Logo
11:01 am - 1:16 pm
EYW
-
TYS
2h 15mnonstop
$66Allegiant Air
Mon, Apr 27 - Fri, May 1
Allegiant Air Logo
8:00 am - 10:11 am
TYS
-
EYW
2h 11mnonstop
Allegiant Air Logo
11:01 am - 1:16 pm
EYW
-
TYS
2h 15mnonstop
$77Allegiant Air
Fri, May 8 - Mon, May 11
Allegiant Air Logo
7:30 am - 9:41 am
TYS
-
EYW
2h 11mnonstop
Allegiant Air Logo
10:31 am - 12:46 pm
EYW
-
TYS
2h 15mnonstop
$83Allegiant Air
Fri, Jul 17 - Mon, Jul 20
Allegiant Air Logo
7:30 am - 9:41 am
TYS
-
EYW
2h 11mnonstop
Allegiant Air Logo
10:31 am - 12:46 pm
EYW
-
TYS
2h 15mnonstop
$84Allegiant Air
Fri, Jul 17 - Mon, Jul 20
Allegiant Air Logo
8:00 am - 10:11 am
TYS
-
EYW
2h 11mnonstop
Allegiant Air Logo
11:01 am - 1:16 pm
EYW
-
TYS
2h 15mnonstop
$86Allegiant Air
Fri, May 8 - Mon, May 11
Allegiant Air Logo
8:00 am - 10:11 am
TYS
-
EYW
2h 11mnonstop
Allegiant Air Logo
11:01 am - 1:16 pm
EYW
-
TYS
2h 15mnonstop
$93Allegiant Air
Fri, Apr 24 - Mon, Apr 27
Frontier Logo
8:32 pm - 5:38 am
TYS
-
MIA
9h 06m
1 stop
Frontier Logo
6:30 am - 7:33 pm
MIA
-
TYS
13h 03m
1 stop
$205Frontier
Mon, May 11 - Mon, May 18
Multiple Airlines Logo
9:40 pm - 8:27 am
TYS
-
MIA
34h 47m
2 stops
Multiple Airlines Logo
8:47 pm - 8:56 pm
MIA
-
TYS
24h 09m
1 stop
$214Multiple Airlines
Thu, May 14 - Wed, May 20
Frontier Logo
4:28 pm - 5:05 am
TYS
-
MIA
12h 37m
1 stop
Frontier Logo
7:00 am - 3:33 pm
MIA
-
TYS
8h 33m
1 stop
$225Frontier
Sun, Apr 26 - Sun, May 3

Frontier flights from Knoxville to Florida Keys

Our best Frontier deals on Knoxville to Florida Keys flight tickets
Frontier
May 11
TYS8:32 pmKnoxville McGhee Tyson
9h 06m
1 stop
MIA5:38 amMiami
May 18
MIA6:30 amMiami
13h 03m
1 stop
TYS7:33 pmKnoxville McGhee Tyson
$205
Frontier
Apr 26
TYS4:28 pmKnoxville McGhee Tyson
12h 37m
1 stop
MIA5:05 amMiami
May 3
MIA7:00 amMiami
8h 33m
1 stop
TYS3:33 pmKnoxville McGhee Tyson
$225
Frontier
Apr 26
TYS4:28 pmKnoxville McGhee Tyson
12h 37m
1 stop
MIA5:05 amMiami
Apr 30
MIA7:00 amMiami
8h 33m
1 stop
TYS3:33 pmKnoxville McGhee Tyson
$256

Southwest flights from Knoxville to Florida Keys

Our best Southwest deals on Knoxville to Florida Keys flight tickets
Southwest
May 13
TYS8:15 amKnoxville McGhee Tyson
6h 00m
1 stop
MIA2:15 pmMiami
May 20
MIA12:10 pmMiami
7h 30m
1 stop
TYS7:40 pmKnoxville McGhee Tyson
$295
Southwest
May 12
TYS7:05 amKnoxville McGhee Tyson
5h 35m
1 stop
MIA12:40 pmMiami
May 19
MIA6:15 amMiami
8h 05m
2 stops
TYS2:20 pmKnoxville McGhee Tyson
$300
Southwest
May 13
TYS8:15 amKnoxville McGhee Tyson
12h 25m
2 stops
MIA8:40 pmMiami
May 20
MIA7:20 amMiami
9h 50m
2 stops
TYS5:10 pmKnoxville McGhee Tyson
$305

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 14, 2026.
Use the filters below to find and compare flights from Knoxville to Florida Keys that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Mon 4/27

8:00 am-10:11 am

Nonstop2h 11m

Key West

Fri 5/1

11:01 am-1:16 pm

Nonstop2h 15m

$65

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Mon 4/27

8:00 am-10:11 am

Nonstop2h 11m

Key West

Fri 5/1

11:01 am-1:16 pm

Nonstop2h 15m

$66

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Fri 5/8

8:00 am-10:11 am

Nonstop2h 11m

Key West

Mon 5/11

11:01 am-1:16 pm

Nonstop2h 15m

$77

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Fri 7/17

7:30 am-9:41 am

Nonstop2h 11m

Key West

Mon 7/20

10:31 am-12:46 pm

Nonstop2h 15m

$83

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Fri 7/17

7:30 am-9:41 am

Nonstop2h 11m

Key West

Mon 7/20

10:31 am-12:46 pm

Nonstop2h 15m

$84

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Fri 5/8

8:00 am-10:11 am

Nonstop2h 11m

Key West

Mon 5/11

11:01 am-1:16 pm

Nonstop2h 15m

$86

KnoxvilleKey West

TYS - EYW

TYSEYW

Knoxville McGhee Tyson

Fri 4/24

8:00 am-10:11 am

Nonstop2h 11m

Key West

Mon 4/27

11:01 am-1:16 pm

Nonstop2h 15m

$93

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Mon 5/11

8:32 pm-5:38 am

1 stop9h 06m

Miami

Mon 5/18

6:30 am-7:33 pm

1 stop13h 03m

$205

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Thu 5/14

9:40 pm-8:27 am

2 stops34h 47m

Miami

Wed 5/20

8:47 pm-8:56 pm

1 stop24h 09m

$214

KnoxvilleMiami

TYS - MIA

TYSMIA

Knoxville McGhee Tyson

Sun 4/26

4:28 pm-5:05 am

1 stop12h 37m

Miami

Sun 5/3

7:00 am-3:33 pm

1 stop8h 33m

$225

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Florida Keys from

How to get the cheapest flight ticket from Knoxville to Florida Keys

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Florida Keys?

The month of July is another great option to travel to Florida Keys, with average flight prices from Knoxville averaging around $371.

What is the cheapest day to depart on your flight to Florida Keys?

The cheapest day to depart from Knoxville to Florida Keys is on a Friday when prices can be found for as low as $481. The most expensive day to fly to Florida Keys is Sunday, with ticket prices averaging around $600.

What is the cheapest time of day to depart on your flight to Florida Keys?

According to our data, the cheapest time of day to fly to Florida Keys is in the afternoon. momondo users have found flights departing from Knoxville to Florida Keys in the afternoon for as low as $403. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights in the morning are often more expensive with an average ticket price of $580.

What is the cheapest Knoxville McGhee Tyson to Florida Keys flight route?

Fly from Knoxville McGhee Tyson to Key West for the best Knoxville McGhee Tyson - Florida Keys flight prices

How far in advance should I book a flight to Florida Keys?

You are more likely to see cheaper flights to Florida Keys from Knoxville when booking weeks ahead of your departure date. In general, you can expect to find flights to Florida Keys for around $403 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Florida Keys from Knoxville for as low as $324 on momondo.

What cabin class options are available on Knoxville McGhee Tyson to Florida Keys flights?

There is only 1 cabin class available to choose from on Knoxville McGhee Tyson to Florida Keys flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Knoxville to Florida Keys flights?

No. A direct flight is the cheapest option for a flight between Knoxville to Florida Keys.

Cheap Knoxville to Florida Keys flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Florida Keys

Fastest flight time

2h 07m

Direct flights

Every day

Airports in Florida Keys

3 airports
The fastest flight from Knoxville to Florida Keys takes 2h 07m
Direct flights go from Knoxville to Florida Keys every day.
There are 3 airports in Florida Keys. From Knoxville there are direct flights to Miami (MIA).

Frequently asked questions about flying from Knoxville to Florida Keys

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Florida Keys?

    Prices for flights from Knoxville McGhee Tyson Airport to Florida Keys refresh daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Florida Keys?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Florida Keys?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Knoxville McGhee Tyson Airport to Florida Keys.

  • What documentation or ID do you need to fly to Florida Keys?

    The travel and health documents required for your trip to Florida Keys can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Florida Keys. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Knoxville to Florida Keys?

Best airlines flying from Knoxville to Florida Keys

Compare and see reviews for airlines that fly from Knoxville to Florida Keys with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $84Free CancellationRating
7.3
707 reviews
Search Allegiant Air flights
American AirlinesPriceFrom $250Free CancellationRating
7.1
11,580 reviews
Search American Airlines flights
DeltaPriceFrom $273Free CancellationRating
7.9
8,404 reviews
Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Florida Keys?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Knoxville to Florida Keys for you.

Can I find flights from Knoxville to Florida Keys with flexible booking policies on momondo?

All flight searches from Knoxville to Florida Keys on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to Florida Keys?

momondo provides multiple filters to help you find the best flight to Florida Keys from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to Florida Keys right now. Can momondo alert me if prices change?

Price alerts on flights to Florida Keys from Knoxville are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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1 adult
Thu 5/14
Thu 5/21

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