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Cheap flights from Columbus Airport to Florence from $481

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Columbus Airport to Florence departing on 11/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

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American Airlines Logo
6:02 pm - 12:07 amCMH-FLO
6h 05m1 stop
American Airlines Logo
6:15 am - 12:08 pmFLO-CMH
5h 53m1 stop
$481American Airlines
Find Deal
Sat, Nov 15 - Wed, Nov 19
American Airlines Logo
4:02 pm - 12:07 amCMH-FLO
8h 05m2 stops
American Airlines Logo
6:15 am - 12:08 pmFLO-CMH
5h 53m1 stop
$486American Airlines
Find Deal
Sat, Nov 15 - Wed, Nov 19
American Airlines Logo
4:02 pm - 12:07 amCMH-FLO
8h 05m2 stops
American Airlines Logo
6:15 am - 3:28 pmFLO-CMH
9h 13m2 stops
$491American Airlines
Find Deal
Sat, Nov 15 - Wed, Nov 19
American Airlines Logo
6:02 pm - 11:41 pmCMH-FLO
5h 39m1 stop
American Airlines Logo
11:11 am - 5:32 pmFLO-CMH
6h 21m1 stop
$559American Airlines
Find Deal
Fri, Nov 21 - Sun, Nov 23
American Airlines Logo
2:37 pm - 11:41 pmCMH-FLO
9h 04m2 stops
American Airlines Logo
11:11 am - 3:23 pmFLO-CMH
4h 12m1 stop
$564American Airlines
Find Deal
Fri, Nov 21 - Sun, Nov 23
American Airlines Logo
12:16 pm - 11:41 pmCMH-FLO
11h 25m2 stops
American Airlines Logo
11:11 am - 6:54 pmFLO-CMH
7h 43m2 stops
$569American Airlines
Find Deal
Fri, Nov 21 - Sun, Nov 23
American Airlines Logo
8:17 pm - 11:41 pmCMH-FLO
3h 24m1 stop
American Airlines Logo
11:11 am - 5:32 pmFLO-CMH
6h 21m1 stop
$637American Airlines
Find Deal
Wed, Nov 26 - Sat, Nov 29
American Airlines Logo
2:34 pm - 11:41 pmCMH-FLO
9h 07m2 stops
American Airlines Logo
11:11 am - 3:23 pmFLO-CMH
4h 12m1 stop
$671American Airlines
Find Deal
Wed, Nov 26 - Sat, Nov 29
American Airlines Logo
2:34 pm - 11:41 pmCMH-FLO
9h 07m2 stops
American Airlines Logo
5:15 am - 11:37 amFLO-CMH
6h 22m2 stops
$743American Airlines
Find Deal
Wed, Nov 26 - Sat, Nov 29

American Airlines flights from Columbus Airport to Florence, South Carolina

Our best American Airlines deals on Columbus Airport to Florence, South Carolina flight tickets
American Airlines
Nov 15
CMH6:02 pmColumbus
6h 05m
1 stop
FLO12:07 amFlorence
Nov 19
FLO6:15 amFlorence
5h 53m
1 stop
CMH12:08 pmColumbus
$481
Find similar
American Airlines
Nov 15
CMH4:02 pmColumbus
8h 05m
2 stops
FLO12:07 amFlorence
Nov 19
FLO6:15 amFlorence
5h 53m
1 stop
CMH12:08 pmColumbus
$486
Find similar
American Airlines
Nov 15
CMH4:02 pmColumbus
8h 05m
2 stops
FLO12:07 amFlorence
Nov 19
FLO6:15 amFlorence
9h 13m
2 stops
CMH3:28 pmColumbus
$491
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Columbus Airport to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 2, 2025.
Use the filters below to find and compare flights from Columbus Airport to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Sat 11/15

6:02 pm-12:07 am

1 stop6h 05m

Florence

Wed 11/19

6:15 am-12:08 pm

1 stop5h 53m

$481

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Sat 11/15

4:02 pm-12:07 am

2 stops8h 05m

Florence

Wed 11/19

6:15 am-12:08 pm

1 stop5h 53m

$486

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Sat 11/15

4:02 pm-12:07 am

2 stops8h 05m

Florence

Wed 11/19

6:15 am-3:28 pm

2 stops9h 13m

$491

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Fri 11/21

6:02 pm-11:41 pm

1 stop5h 39m

Florence

Sun 11/23

11:11 am-5:32 pm

1 stop6h 21m

$559

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Fri 11/21

2:37 pm-11:41 pm

2 stops9h 04m

Florence

Sun 11/23

11:11 am-3:23 pm

1 stop4h 12m

$564

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Fri 11/21

12:16 pm-11:41 pm

2 stops11h 25m

Florence

Sun 11/23

11:11 am-6:54 pm

2 stops7h 43m

$569

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Wed 11/26

8:17 pm-11:41 pm

1 stop3h 24m

Florence

Sat 11/29

11:11 am-5:32 pm

1 stop6h 21m

$637

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Wed 11/26

2:34 pm-11:41 pm

2 stops9h 07m

Florence

Sat 11/29

11:11 am-3:23 pm

1 stop4h 12m

$671

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Wed 11/26

2:34 pm-11:41 pm

2 stops9h 07m

Florence

Sat 11/29

5:15 am-11:37 am

2 stops6h 22m

$743

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Columbus Airport to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Florence, South Carolina?

American Airlines, Breeze Airways and Delta are the top three most popular airlines that fly to Florence, South Carolina from Columbus Airport according to our data. American Airlines is the first choice among our users, with 54% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 7 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Columbus Airport to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Columbus Airport to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Columbus Airport to Florence, South Carolina (CMH to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbus Airport to Florence, South Carolina

Direct flights

None
There are no direct flights from Columbus Airport to Florence, South Carolina. There are no popular flight routes from Columbus Airport to Florence, South Carolina.
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  • How far is Columbus to Florence by plane?

    Florence is 436.0 mi away from Columbus. A reasonable flight in good conditions will take 3h 24m.

  • When did momondo last update prices for flights from Columbus Airport to Florence Airport?

    Prices for flights from Columbus Airport to Florence Airport were last updated today.

  • How old do you have to be to fly from Columbus Airport to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Columbus Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents required for your trip to Florence Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Florence Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Columbus to Florence?

It is quick and easy to find Columbus to Florence flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Florence that suits you.

Can I find flights from Columbus to Florence with flexible booking policies on momondo?

All flight searches from Columbus to Florence on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Columbus to Florence?

momondo provides multiple filters to help you find the best flight to Florence from Columbus. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Columbus to Florence right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Columbus to Florence now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Florence and let you know when they change.

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