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Cheap flights from Columbus Airport to Florence from $384

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Columbus Airport to Florence departing on 8/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Columbus Airport to Florence

Cheap round-trip flights

American Airlines Logo
6:00 am - 10:53 amCMH-FLO
4h 53m1 stop
American Airlines Logo
6:14 am - 12:36 pmFLO-CMH
6h 22m1 stop
$475American Airlines
Find Deal
Sun, Sep 7 - Sat, Sep 13
American Airlines Logo
8:16 pm - 12:13 amCMH-FLO
3h 57m1 stop
American Airlines Logo
6:14 am - 4:48 pmFLO-CMH
10h 34m2 stops
$480American Airlines
Find Deal
Sun, Sep 7 - Sat, Sep 13
American Airlines Logo
5:37 am - 4:32 pmCMH-FLO
10h 55m2 stops
American Airlines Logo
6:14 am - 4:48 pmFLO-CMH
10h 34m2 stops
$485American Airlines
Find Deal
Sun, Sep 7 - Sat, Sep 13
American Airlines Logo
4:50 pm - 11:02 pmCMH-FLO
6h 12m1 stop
American Airlines Logo
5:09 am - 9:54 amFLO-CMH
4h 45m1 stop
$509American Airlines
Find Deal
Wed, Aug 13 - Sun, Aug 17
American Airlines Logo
6:50 am - 3:04 pmCMH-FLO
8h 14m2 stops
American Airlines Logo
5:09 am - 9:54 amFLO-CMH
4h 45m1 stop
$514American Airlines
Find Deal
Wed, Aug 13 - Sun, Aug 17
American Airlines Logo
6:30 am - 3:04 pmCMH-FLO
8h 34m2 stops
American Airlines Logo
5:09 am - 3:24 pmFLO-CMH
10h 15m2 stops
$519American Airlines
Find Deal
Wed, Aug 13 - Sun, Aug 17

American Airlines flights from Columbus Airport to Florence, South Carolina

Our best American Airlines deals on Columbus Airport to Florence, South Carolina flight tickets
American Airlines
Sep 7
CMH6:00 amColumbus
4h 53m
1 stop
FLO10:53 amFlorence
Sep 13
FLO6:14 amFlorence
6h 22m
1 stop
CMH12:36 pmColumbus
$475
Find similar
American Airlines
Sep 7
CMH8:16 pmColumbus
3h 57m
1 stop
FLO12:13 amFlorence
Sep 13
FLO6:14 amFlorence
10h 34m
2 stops
CMH4:48 pmColumbus
$480
Find similar
American Airlines
Sep 7
CMH5:37 amColumbus
10h 55m
2 stops
FLO4:32 pmFlorence
Sep 13
FLO6:14 amFlorence
10h 34m
2 stops
CMH4:48 pmColumbus
$485
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Columbus Airport to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Columbus Airport to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Sun 9/7

6:00 am-10:53 am

1 stop4h 53m

Florence

Sat 9/13

6:14 am-12:36 pm

1 stop6h 22m

$475

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Sun 9/7

8:16 pm-12:13 am

1 stop3h 57m

Florence

Sat 9/13

6:14 am-4:48 pm

2 stops10h 34m

$480

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Sun 9/7

5:37 am-4:32 pm

2 stops10h 55m

Florence

Sat 9/13

6:14 am-4:48 pm

2 stops10h 34m

$485

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Wed 8/13

4:50 pm-11:02 pm

1 stop6h 12m

Florence

Sun 8/17

5:09 am-9:54 am

1 stop4h 45m

$509

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Wed 8/13

6:50 am-3:04 pm

2 stops8h 14m

Florence

Sun 8/17

5:09 am-9:54 am

1 stop4h 45m

$514

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Wed 8/13

6:30 am-3:04 pm

2 stops8h 34m

Florence

Sun 8/17

5:09 am-3:24 pm

2 stops10h 15m

$519

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Sat 8/9

6:02 pm-11:59 pm

1 stop5h 57m

$384

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Sat 8/9

6:00 am-2:09 pm

2 stops8h 09m

$389

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Sun 8/10

10:31 am-2:09 pm

1 stop3h 38m

$418

ColumbusFlorence

CMH - FLO

CMHFLO

Columbus

Sun 8/10

1:12 pm-11:59 pm

2 stops10h 47m

$423

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Columbus Airport to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Columbus to Florence?

American Airlines is the most popular carrier operating from Columbus to Florence

What airlines fly to Florence, South Carolina?

American Airlines, Breeze Airways and Delta are the top three most popular airlines that fly to Florence, South Carolina from Columbus Airport according to our data. American Airlines is the first choice among our users, with 56% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 7 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Columbus Airport to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Columbus Airport to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Columbus Airport to Florence, South Carolina (CMH to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Columbus Airport to Florence, South Carolina

Best Price Found

$384

Fastest flight time

3h 38m

Direct flights

None

Airports in Florence, South Carolina

1 airport
The best one-way flight to Florence, South Carolina from Columbus Airport in the past 72 hours is $384. The best round-trip flight deal from Columbus Airport to Florence, South Carolina found on momondo in the last 72 hours is $475.
The fastest flight from Columbus Airport to Florence, South Carolina takes 3h 38m
There are no direct flights from Columbus Airport to Florence, South Carolina. Popular non-direct route for this connection is Columbus Airport - Florence Airport.
There is 1 airport near Florence, South Carolina: Florence (FLO)
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  • How far is Columbus to Florence by plane?

    Florence is 436.0 mi away from Columbus. A reasonable flight in good conditions will take 3h 57m.

  • When did momondo last update prices for flights from Columbus Airport to Florence Airport?

    Prices for flights from Columbus Airport to Florence Airport were last updated today.

  • How many operators does momondo search for flights from Columbus Airport to Florence Airport?

  • How old do you have to be to fly from Columbus Airport to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Columbus Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents required for your trip to Florence Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Florence Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Columbus Airport to Florence, South Carolina?

Best airlines flying from Columbus Airport to Florence, South Carolina

Compare and see reviews for airlines that fly from Columbus Airport to Florence, South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $356Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Lake City
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Columbus to Florence?

It is quick and easy to find Columbus to Florence flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Florence that suits you.

Can I find flights from Columbus to Florence with flexible booking policies on momondo?

All flight searches from Columbus to Florence on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Columbus to Florence?

momondo provides multiple filters to help you find the best flight to Florence from Columbus. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Columbus to Florence right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Columbus to Florence now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Florence and let you know when they change.

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