What is the cheapest airline that flies from Iowa to Greenville?

Delta, Southwest, and American Airlines are the most popular carriers operating from Iowa to Greenville

How long does it take to fly to Greenville?

Flight times from Iowa to Greenville vary, but if you’re flying out of Cedar Rapids and flying into Charlotte (one of the most popular routes), then the duration is 2h 11m on average. Another popular route from Iowa to Greenville is flying from Des Moines to Charlotte, which will take roughly 2h 19m. Keep in mind that layovers or delays could extend your travel time.

What airlines fly to Greenville?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Greenville from Iowa according to our data. American Airlines is the first choice among our users, with 79% of people opting to fly with this airline when traveling to Greenville. Keep in mind that there are 3 different airlines that fly to Greenville on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Iowa to Greenville Airport?

Prices for flights from Iowa to Greenville Airport were last updated today.

How many operators does momondo search for flights from Iowa to Greenville Airport?

There are 4 operators available for flights from Iowa to Greenville Airport as of September 2025.

How old do you have to be to fly from Iowa to Greenville Airport?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Iowa to Greenville Airport.

What documentation or ID do you need to fly to Greenville Airport?

The travel and health documents you'll need for your trip to Greenville Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Greenville Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$224 Cheap Flights from Iowa to Greenville in 2025/26

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Find the cheapest flights from Iowa to Greenville

Round-trip

One-way

Last minute

Cheap round-trip flights

6:00 am - 10:52 amMLI-GSP

3h 52m1 stop

6:12 am - 9:20 amGSP-MLI

4h 08m1 stop

$249American Airlines

Find Deal

Tue, Oct 28 - Mon, Nov 3

5:35 am - 1:10 pmDSM-GSP

6h 35m1 stop

10:07 am - 1:32 pmGSP-DSM

4h 25m1 stop

$251Delta

Find Deal

Tue, Nov 11 - Tue, Nov 18

6:30 am - 11:49 amCID-GSP

4h 19m1 stop

10:00 am - 9:20 pmGSP-CID

12h 20m2 stops

$254United Airlines

Find Deal

Thu, Nov 27 - Wed, Dec 3

7:46 pm - 3:05 pmOMA-GSP

18h 19m2 stops

5:21 pm - 9:18 amGSP-OMA

16h 57m1 stop

$284Multiple Airlines

Find Deal

Thu, Nov 13 - Sun, Nov 16

9:19 am - 12:37 pmDSM-GSP

26h 18m1 stop

9:53 pm - 11:24 pmGSP-DSM

26h 31m1 stop

$290Allegiant Air

Find Deal

Thu, Nov 20 - Mon, Nov 24

9:19 am - 12:37 pmDSM-GSP

26h 18m1 stop

8:03 pm - 9:09 pmGSP-DSM

26h 06m1 stop

$324Multiple Airlines

Find Deal

Thu, Nov 20 - Sun, Nov 23

1:05 pm - 11:56 pmDSM-GSP

9h 51m2 stops

2:55 pm - 11:44 pmGSP-DSM

9h 49m2 stops

$331United Airlines

Find Deal

Tue, Nov 11 - Tue, Nov 18

9:19 am - 12:37 pmDSM-GSP

26h 18m1 stop

9:34 pm - 8:29 amGSP-DSM

11h 55m1 stop

$351Allegiant Air

Find Deal

Thu, Nov 20 - Sat, Nov 22

12:40 pm - 7:25 pmOMA-GSP

5h 45m2 stops

8:00 am - 5:10 pmGSP-OMA

10h 10m2 stops

$457Southwest

Find Deal

Thu, Nov 13 - Sun, Nov 16

12:40 pm - 7:25 pmOMA-GSP

5h 45m2 stops

8:00 am - 7:15 pmGSP-OMA

12h 15m2 stops

$458Southwest

Find Deal

Thu, Nov 13 - Sun, Nov 16

Delta flights from Iowa to Greenville

Our best Delta deals on Iowa to Greenville flight tickets

Delta

Nov 11

DSM5:35 amDes Moines

6h 35m

1 stop

GSP1:10 pmGreenville

Nov 18

GSP10:07 amGreenville

4h 25m

1 stop

DSM1:32 pmDes Moines

$251

Find similar

Delta

Oct 25

DSM5:15 pmDes Moines

5h 40m

1 stop

GSP11:55 pmGreenville

Oct 28

GSP6:35 amGreenville

4h 30m

1 stop

DSM10:05 amDes Moines

$254

Find similar

Delta

Nov 27

CID12:29 pmCedar Rapids

10h 16m

2 stops

GSP11:45 pmGreenville

Dec 3

GSP7:27 amGreenville

9h 18m

2 stops

CID3:45 pmCedar Rapids

$289

Find similar

American Airlines flights from Iowa to Greenville

Our best American Airlines deals on Iowa to Greenville flight tickets

American Airlines

Oct 28

MLI6:00 amMoline Quad-City

3h 52m

1 stop

GSP10:52 amGreenville

Nov 3

GSP6:12 amGreenville

4h 08m

1 stop

MLI9:20 amMoline Quad-City

$249

Find similar

American Airlines

Oct 28

MLI6:00 amMoline Quad-City

10h 05m

2 stops

GSP5:05 pmGreenville

Nov 3

GSP6:12 amGreenville

4h 08m

1 stop

MLI9:20 amMoline Quad-City

$254

Find similar

American Airlines

Nov 11

DSM2:19 pmDes Moines

7h 41m

2 stops

GSP11:00 pmGreenville

Nov 18

GSP7:38 amGreenville

5h 46m

1 stop

DSM12:24 pmDes Moines

$256

Find similar

Fly from

Fly to

Route

Depart

Return

Price

MolineGreenville

MLI - GSP

MLIGSP

Moline Quad-City

Tue 10/28

6:00 am-10:52 am

1 stop3h 52m

Greenville

Mon 11/3

6:12 am-9:20 am

1 stop4h 08m

$249

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Tue 11/11

5:35 am-1:10 pm

1 stop6h 35m

Greenville

Tue 11/18

10:07 am-1:32 pm

1 stop4h 25m

$251

Cedar RapidsGreenville

CID - GSP

CIDGSP

Cedar Rapids

Thu 11/27

6:30 am-11:49 am

1 stop4h 19m

Greenville

Wed 12/3

10:00 am-9:20 pm

2 stops12h 20m

$254

OmahaGreenville

OMA - GSP

OMAGSP

Omaha Eppley Airfield

Thu 11/13

7:46 pm-3:05 pm

2 stops18h 19m

Greenville

Sun 11/16

5:21 pm-9:18 am

1 stop16h 57m

$284

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 11/20

9:19 am-12:37 pm

1 stop26h 18m

Greenville

Mon 11/24

9:53 pm-11:24 pm

1 stop26h 31m

$290

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 11/20

9:19 am-12:37 pm

1 stop26h 18m

Greenville

Sun 11/23

8:03 pm-9:09 pm

1 stop26h 06m

$324

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Tue 11/11

1:05 pm-11:56 pm

2 stops9h 51m

Greenville

Tue 11/18

2:55 pm-11:44 pm

2 stops9h 49m

$331

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 11/20

9:19 am-12:37 pm

1 stop26h 18m

Greenville

Sat 11/22

9:34 pm-8:29 am

1 stop11h 55m

$351

OmahaGreenville

OMA - GSP

OMAGSP

Omaha Eppley Airfield

Thu 11/13

12:40 pm-7:25 pm

2 stops5h 45m

Greenville

Sun 11/16

8:00 am-5:10 pm

2 stops10h 10m

$457

OmahaGreenville

OMA - GSP

OMAGSP

Omaha Eppley Airfield

Thu 11/13

12:40 pm-7:25 pm

2 stops5h 45m

Greenville

Sun 11/16

8:00 am-7:15 pm

2 stops12h 15m

$458

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Iowa to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Greenville?

The month of October is another great option to travel to Greenville, with average flight prices from Iowa averaging around $304.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Friday is the cheapest day to fly to Greenville from Iowa. The lowest ticket price found for a Friday departure recently was $349. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Tuesday because tickets tend to average around $608. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the afternoon. Flights from Iowa to Greenville during this time can be as low as $373. Flights to Greenville are more costly in the morning, with an average ticket price of $437. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

Can stopping save me money on Iowa to Greenville flights?

You could potentially save up to 18% on your flight if you consider stops on a Iowa to Greenville flight.

Cheap Iowa to Greenville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Iowa to Greenville

Direct flights	None

There are no direct flights from Iowa to Greenville. There are no popular flight routes from Iowa to Greenville.

Search flight deals

When did momondo last update prices for flights from Iowa to Greenville Airport?
Prices for flights from Iowa to Greenville Airport were last updated today.
How many operators does momondo search for flights from Iowa to Greenville Airport?
There are 4 operators available for flights from Iowa to Greenville Airport as of September 2025.
How old do you have to be to fly from Iowa to Greenville Airport?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Iowa to Greenville Airport.
What documentation or ID do you need to fly to Greenville Airport?
The travel and health documents you'll need for your trip to Greenville Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Greenville Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Iowa to Greenville

Compare and see reviews for airlines that fly from Iowa to Greenville with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $232	Free Cancellation	Rating 7.9 7,964 reviews	Search Delta flights
American Airlines	PriceFrom $248	Free Cancellation	Rating 7.2 10,000 reviews	Search American Airlines flights
United Airlines	PriceFrom $248	Free Cancellation	Rating 7.4 8,924 reviews	Search United Airlines flights

Anderson

Simpsonville

Greenwood

Seneca

Greer

Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Iowa to Greenville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Greenville from Iowa.

Can I find flights from Iowa to Greenville with flexible booking policies on momondo?

All flight searches from Iowa to Greenville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Iowa to Greenville?

momondo provides multiple filters to help you find the best flight to Greenville from Iowa. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Iowa to Greenville right now. Can momondo alert me if prices change?

Price alerts on flights to Greenville from Iowa are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Greenville trip

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Cheap flights from Iowa to Greenville from $224

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Iowa to Greenville departing on 10/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

Big names and deals

Big names and deals

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Filter for what you want

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Find the cheapest flights from Iowa to Greenville

Cheap round-trip flights

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Cheap last minute flights

Delta flights from Iowa to Greenville

Our best Delta deals on Iowa to Greenville flight tickets

American Airlines flights from Iowa to Greenville

Our best American Airlines deals on Iowa to Greenville flight tickets

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Use the filters below to find and compare flights from Iowa to Greenville that are best for you.

See travel insights to Greenville from

How to get the cheapest flight ticket from Iowa to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Greenville?

The month of October is another great option to travel to Greenville, with average flight prices from Iowa averaging around $304.

What is the cheapest day to depart on your flight to Greenville?

What is the cheapest time of day to depart on your flight to Greenville?

Can stopping save me money on Iowa to Greenville flights?

You could potentially save up to 18% on your flight if you consider stops on a Iowa to Greenville flight.

What is the cheapest airline that flies from Iowa to Greenville?

Delta, Southwest, and American Airlines are the most popular carriers operating from Iowa to Greenville

What airlines fly to Greenville?

How long does it take to fly to Greenville?

Cheap Iowa to Greenville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Iowa to Greenville

Direct flights

When did momondo last update prices for flights from Iowa to Greenville Airport?

How many operators does momondo search for flights from Iowa to Greenville Airport?

How old do you have to be to fly from Iowa to Greenville Airport?

What documentation or ID do you need to fly to Greenville Airport?

Best airlines flying from Iowa to Greenville

Compare and see reviews for airlines that fly from Iowa to Greenville with momondo

Traveling to a place near Greenville?

Why use momondo?

Why should I use momondo to find a flight deal from Iowa to Greenville?

Can I find flights from Iowa to Greenville with flexible booking policies on momondo?

How can momondo help me find flights from Iowa to Greenville?

I’m not ready to book a flight from Iowa to Greenville right now. Can momondo alert me if prices change?

An easier way to manage your Greenville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to the United States

Airports servicing South Carolina