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Cheap flights from Iowa to Greenville from $138

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Iowa to Greenville departing on 4/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Iowa to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
7:28 am - 3:14 pm
DSM
-
GSP
6h 46m
1 stop
Delta Logo
5:42 am - 11:05 am
GSP
-
DSM
6h 23m
1 stop
$263Delta
mar., abr. 21 - mié., abr. 22
American Airlines Logo
5:01 pm - 11:03 pm
DSM
-
GSP
5h 02m
1 stop
American Airlines Logo
5:20 am - 11:30 am
GSP
-
DSM
7h 10m
2 stops
$268American Airlines
mar., abr. 21 - mié., abr. 22
American Airlines Logo
6:00 am - 3:03 pm
DSM
-
GSP
8h 03m
2 stops
American Airlines Logo
5:20 am - 11:30 am
GSP
-
DSM
7h 10m
2 stops
$273American Airlines
mar., abr. 21 - mié., abr. 22
Southwest Logo
5:30 am - 8:00 pm
DSM
-
GSP
13h 30m
2 stops
Southwest Logo
5:05 pm - 10:10 pm
GSP
-
DSM
6h 05m
2 stops
$279Southwest
mar., abr. 28 - mar., may. 5
United Airlines Logo
6:00 am - 11:54 am
OMA
-
GSP
4h 54m
1 stop
United Airlines Logo
7:00 am - 2:20 pm
GSP
-
OMA
8h 20m
1 stop
$290United Airlines
mié., abr. 22 - sáb., abr. 25
Delta Logo
6:31 pm - 11:56 pm
DSM
-
GSP
4h 25m
1 stop
Delta Logo
11:35 am - 7:28 pm
GSP
-
DSM
8h 53m
1 stop
$290Delta
lun., abr. 27 - mar., may. 5
Southwest Logo
4:20 pm - 9:40 pm
OMA
-
GSP
4h 20m
1 stop
Southwest Logo
5:05 pm - 10:20 pm
GSP
-
OMA
6h 15m
2 stops
$293Southwest
mar., abr. 14 - mié., abr. 22
United Airlines Logo
3:22 pm - 8:47 pm
OMA
-
GSP
4h 25m
1 stop
United Airlines Logo
6:00 am - 3:44 pm
GSP
-
OMA
10h 44m
2 stops
$295United Airlines
mié., abr. 22 - sáb., abr. 25
American Airlines Logo
5:01 pm - 11:03 pm
DSM
-
GSP
5h 02m
1 stop
American Airlines Logo
6:00 am - 1:46 pm
GSP
-
DSM
8h 46m
2 stops
$295American Airlines
lun., abr. 27 - mar., may. 5
Multiple Airlines Logo
11:00 am - 7:29 am
DSM
-
GSP
19h 29m
2 stops
Multiple Airlines Logo
4:03 pm - 5:54 pm
GSP
-
DSM
26h 51m
1 stop
$331Multiple Airlines
mié., jun. 17 - dom., jun. 21

United Airlines flights from Iowa to Greenville

Our best United Airlines deals on Iowa to Greenville flight tickets
United Airlines
Apr 22
OMA6:00 amOmaha Eppley Airfield
4h 54m
1 stop
GSP11:54 amGreenville
Apr 25
GSP7:00 amGreenville
8h 20m
1 stop
OMA2:20 pmOmaha Eppley Airfield
$290
United Airlines
Apr 22
OMA3:22 pmOmaha Eppley Airfield
4h 25m
1 stop
GSP8:47 pmGreenville
Apr 25
GSP6:00 amGreenville
10h 44m
2 stops
OMA3:44 pmOmaha Eppley Airfield
$295
United Airlines
Apr 21
OMA6:00 amOmaha Eppley Airfield
7h 12m
2 stops
GSP2:12 pmGreenville
Apr 30
GSP4:35 pmGreenville
8h 07m
1 stop
OMA11:42 pmOmaha Eppley Airfield
$313

Southwest flights from Iowa to Greenville

Our best Southwest deals on Iowa to Greenville flight tickets
Southwest
Apr 28
DSM5:30 amDes Moines
13h 30m
2 stops
GSP8:00 pmGreenville
May 5
GSP5:05 pmGreenville
6h 05m
2 stops
DSM10:10 pmDes Moines
$279
Southwest
Apr 14
OMA4:20 pmOmaha Eppley Airfield
4h 20m
1 stop
GSP9:40 pmGreenville
Apr 22
GSP5:05 pmGreenville
6h 15m
2 stops
OMA10:20 pmOmaha Eppley Airfield
$293
Southwest
Apr 22
OMA1:55 pmOmaha Eppley Airfield
6h 45m
2 stops
GSP9:40 pmGreenville
Apr 25
GSP6:25 amGreenville
4h 10m
1 stop
OMA9:35 amOmaha Eppley Airfield
$296

momondo Fare Finder

 
Customize your flight search to find flights from Iowa to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated marzo 25, 2026.
Use the filters below to find and compare flights from Iowa to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

mar. 4/21

7:28 am-3:14 pm

1 stop6h 46m

Greenville

mié. 4/22

5:42 am-11:05 am

1 stop6h 23m

$263

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

mar. 4/21

5:01 pm-11:03 pm

1 stop5h 02m

Greenville

mié. 4/22

5:20 am-11:30 am

2 stops7h 10m

$268

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

mar. 4/21

6:00 am-3:03 pm

2 stops8h 03m

Greenville

mié. 4/22

5:20 am-11:30 am

2 stops7h 10m

$273

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

mar. 4/28

5:30 am-8:00 pm

2 stops13h 30m

Greenville

mar. 5/5

5:05 pm-10:10 pm

2 stops6h 05m

$279

OmahaGreenville

OMA - GSP

OMAGSP

Omaha Eppley Airfield

mié. 4/22

6:00 am-11:54 am

1 stop4h 54m

Greenville

sáb. 4/25

7:00 am-2:20 pm

1 stop8h 20m

$290

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

lun. 4/27

6:31 pm-11:56 pm

1 stop4h 25m

Greenville

mar. 5/5

11:35 am-7:28 pm

1 stop8h 53m

$290
Quickest round-trip

OmahaGreenville

OMA - GSP

OMAGSP

Omaha Eppley Airfield

mar. 4/14

4:20 pm-9:40 pm

1 stop4h 20m

Greenville

mié. 4/22

5:05 pm-10:20 pm

2 stops6h 15m

$293

OmahaGreenville

OMA - GSP

OMAGSP

Omaha Eppley Airfield

mié. 4/22

3:22 pm-8:47 pm

1 stop4h 25m

Greenville

sáb. 4/25

6:00 am-3:44 pm

2 stops10h 44m

$295

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

lun. 4/27

5:01 pm-11:03 pm

1 stop5h 02m

Greenville

mar. 5/5

6:00 am-1:46 pm

2 stops8h 46m

$295

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

mié. 6/17

11:00 am-7:29 am

2 stops19h 29m

Greenville

dom. 6/21

4:03 pm-5:54 pm

1 stop26h 51m

$331

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Iowa to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Greenville?

The month of October is another great option to travel to Greenville, with average flight prices from Iowa averaging around $295.

Can stopping save me money on Iowa to Greenville flights?

You could potentially save up to 18% on your flight if you consider stops on a Iowa to Greenville flight.

Cheap Iowa to Greenville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Iowa to Greenville

Fastest flight time

4h 13m

Direct flights

None
The fastest flight from Iowa to Greenville takes 4h 13m
There are no direct flights from Iowa to Greenville. There are no popular flight routes from Iowa to Greenville.
Search flight deals

  • When did momondo last update prices for flights from Iowa to Greenville Airport?

    Prices for flights from Iowa to Greenville Airport were last updated today.

  • How many operators does momondo search for flights from Iowa to Greenville Airport?

  • How old do you have to be to fly from Iowa to Greenville Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Iowa to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents you'll need for your trip to Greenville Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Greenville Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Iowa to Greenville

Compare and see reviews for airlines that fly from Iowa to Greenville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $243Free CancellationRating
7.9
8,327 reviews
Search Delta flights
United AirlinesPriceFrom $248Free CancellationRating
7.4
9,478 reviews
Search United Airlines flights
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,493 reviews
Search American Airlines flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Greer
Seneca
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Iowa to Greenville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Greenville from Iowa.

Can I find flights from Iowa to Greenville with flexible booking policies on momondo?

All flight searches from Iowa to Greenville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Iowa to Greenville?

momondo provides multiple filters to help you find the best flight to Greenville from Iowa. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Iowa to Greenville right now. Can momondo alert me if prices change?

Price alerts on flights to Greenville from Iowa are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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