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Cheap flights from Harrisburg to Florence from $437

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Harrisburg to Florence departing on 6/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Harrisburg to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
8:24 am - 2:10 pm
MDT
-
FLO
5h 46m
1 stop
American Airlines Logo
5:05 am - 11:37 am
FLO
-
MDT
6h 32m
1 stop
$437American Airlines
Thu, Jun 25 - Sun, Jun 28
American Airlines Logo
8:24 am - 2:10 pm
MDT
-
FLO
5h 46m
1 stop
American Airlines Logo
5:05 am - 6:28 pm
FLO
-
MDT
13h 23m
2 stops
$679American Airlines
Thu, Jun 25 - Sun, Jun 28
American Airlines Logo
6:42 am - 2:10 pm
MDT
-
FLO
7h 28m
2 stops
American Airlines Logo
2:35 pm - 11:08 pm
FLO
-
MDT
8h 33m
2 stops
$913American Airlines
Thu, Jun 25 - Sun, Jun 28

American Airlines flights from Harrisburg to Florence, South Carolina

Our best American Airlines deals on Harrisburg to Florence, South Carolina flight tickets
American Airlines
Jun 25
MDT8:24 amHarrisburg
5h 46m
1 stop
FLO2:10 pmFlorence
Jun 28
FLO5:05 amFlorence
6h 32m
1 stop
MDT11:37 amHarrisburg
$437
American Airlines
Jun 25
MDT8:24 amHarrisburg
5h 46m
1 stop
FLO2:10 pmFlorence
Jun 28
FLO5:05 amFlorence
13h 23m
2 stops
MDT6:28 pmHarrisburg
$679
American Airlines
Jun 25
MDT6:42 amHarrisburg
7h 28m
2 stops
FLO2:10 pmFlorence
Jun 28
FLO2:35 pmFlorence
8h 33m
2 stops
MDT11:08 pmHarrisburg
$913

momondo Fare Finder

 
Customize your flight search to find flights from Harrisburg to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 4, 2026.
Use the filters below to find and compare flights from Harrisburg to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

HarrisburgFlorence

MDT - FLO

MDTFLO

Harrisburg

Thu 6/25

8:24 am-2:10 pm

1 stop5h 46m

Florence

Sun 6/28

5:05 am-11:37 am

1 stop6h 32m

$437

HarrisburgFlorence

MDT - FLO

MDTFLO

Harrisburg

Thu 6/25

8:24 am-2:10 pm

1 stop5h 46m

Florence

Sun 6/28

5:05 am-6:28 pm

2 stops13h 23m

$679

HarrisburgFlorence

MDT - FLO

MDTFLO

Harrisburg

Thu 6/25

6:42 am-2:10 pm

2 stops7h 28m

Florence

Sun 6/28

2:35 pm-11:08 pm

2 stops8h 33m

$913

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Harrisburg to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Florence, South Carolina?

American Airlines, Southwest and Allegiant Air are the top three most popular airlines that fly to Florence, South Carolina from Harrisburg according to our data. American Airlines is the first choice among our users, with 39% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 6 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Harrisburg to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Harrisburg to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Harrisburg to Florence, South Carolina (MDT to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Harrisburg to Florence, South Carolina

Fastest flight time

5h 46m

Direct flights

None
The fastest flight from Harrisburg to Florence, South Carolina takes 5h 46m
There are no direct flights from Harrisburg to Florence, South Carolina. There are no popular flight routes from Harrisburg to Florence, South Carolina.
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Frequently asked questions about flying from Harrisburg to Florence, South Carolina

  • How far is Harrisburg to Florence by plane?

    Florence is 448.4 mi away from Harrisburg. A reasonable flight in good conditions will take 5h 46m.

  • When did momondo last update prices for flights from Harrisburg Airport to Florence Airport?

    Prices for flights from Harrisburg Airport to Florence Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Harrisburg Airport to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Harrisburg Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Darlington
Hartsville
Lake City
Bennettsville

Why use momondo?

Why should I use momondo to find a flight deal from Harrisburg to Florence?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Harrisburg to Florence for you.

Can I find flights from Harrisburg to Florence with flexible booking policies on momondo?

Yes. All flights to Florence from Harrisburg on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Harrisburg to Florence?

Once all potential Harrisburg to Florence flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Harrisburg to Florence right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Harrisburg to Florence flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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