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Cheap flights from Florida to Florence from $348

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Florida to Florence departing on 5/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Florida to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
4:50 pm - 9:47 pm
TPA
-
FLO
4h 57m
1 stop
American Airlines Logo
5:20 am - 9:55 am
FLO
-
TPA
4h 35m
1 stop
$447American Airlines
Sat, Apr 18 - Sat, Apr 25
American Airlines Logo
3:33 pm - 9:47 pm
TPA
-
FLO
6h 14m
1 stop
American Airlines Logo
5:20 am - 4:09 pm
FLO
-
TPA
10h 49m
2 stops
$452American Airlines
Sat, Apr 18 - Sat, Apr 25
American Airlines Logo
7:22 pm - 12:02 am
FLL
-
FLO
4h 40m
1 stop
American Airlines Logo
11:15 am - 4:27 pm
FLO
-
FLL
5h 12m
1 stop
$471American Airlines
Thu, Sep 3 - Tue, Sep 8
American Airlines Logo
10:40 am - 3:50 pm
TPA
-
FLO
5h 10m
1 stop
American Airlines Logo
4:16 pm - 8:13 pm
FLO
-
TPA
3h 57m
1 stop
$471American Airlines
Sat, Apr 18 - Sun, Apr 19
American Airlines Logo
3:33 pm - 9:47 pm
TPA
-
FLO
6h 14m
1 stop
American Airlines Logo
5:20 am - 9:55 am
FLO
-
TPA
4h 35m
1 stop
$472American Airlines
Sun, May 10 - Sat, May 16
American Airlines Logo
4:50 pm - 9:47 pm
TPA
-
FLO
4h 57m
1 stop
American Airlines Logo
4:16 pm - 11:50 pm
FLO
-
TPA
7h 34m
2 stops
$476American Airlines
Sat, Apr 18 - Sun, Apr 19
American Airlines Logo
11:41 am - 3:50 pm
TPA
-
FLO
4h 09m
1 stop
American Airlines Logo
4:16 pm - 9:58 pm
FLO
-
TPA
5h 42m
1 stop
$477American Airlines
Wed, Apr 15 - Wed, Apr 22
American Airlines Logo
11:41 am - 3:50 pm
TPA
-
FLO
4h 09m
1 stop
American Airlines Logo
4:16 pm - 11:50 pm
FLO
-
TPA
7h 34m
2 stops
$482American Airlines
Wed, Apr 15 - Wed, Apr 22
American Airlines Logo
7:00 am - 3:50 pm
TPA
-
FLO
8h 50m
2 stops
American Airlines Logo
4:16 pm - 11:50 pm
FLO
-
TPA
7h 34m
2 stops
$487American Airlines
Wed, Apr 15 - Wed, Apr 22
American Airlines Logo
9:51 am - 3:50 pm
MCO
-
FLO
5h 59m
1 stop
American Airlines Logo
4:16 pm - 9:59 pm
FLO
-
MCO
5h 43m
1 stop
$495American Airlines
Fri, Apr 17 - Fri, Apr 24

American Airlines flights from Florida to Florence, South Carolina

Our best American Airlines deals on Florida to Florence, South Carolina flight tickets
American Airlines
Apr 18
TPA4:50 pmTampa
4h 57m
1 stop
FLO9:47 pmFlorence
Apr 25
FLO5:20 amFlorence
4h 35m
1 stop
TPA9:55 amTampa
$447
American Airlines
Apr 18
TPA3:33 pmTampa
6h 14m
1 stop
FLO9:47 pmFlorence
Apr 25
FLO5:20 amFlorence
10h 49m
2 stops
TPA4:09 pmTampa
$452
American Airlines
Sep 3
FLL7:22 pmFort Lauderdale
4h 40m
1 stop
FLO12:02 amFlorence
Sep 8
FLO11:15 amFlorence
5h 12m
1 stop
FLL4:27 pmFort Lauderdale
$471

momondo Fare Finder

 
Customize your flight search to find flights from Florida to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 22, 2026.
Use the filters below to find and compare flights from Florida to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sat 4/18

4:50 pm-9:47 pm

1 stop4h 57m

Florence

Sat 4/25

5:20 am-9:55 am

1 stop4h 35m

$447

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sat 4/18

3:33 pm-9:47 pm

1 stop6h 14m

Florence

Sat 4/25

5:20 am-4:09 pm

2 stops10h 49m

$452

Fort LauderdaleFlorence

FLL - FLO

FLLFLO

Fort Lauderdale

Thu 9/3

7:22 pm-12:02 am

1 stop4h 40m

Florence

Tue 9/8

11:15 am-4:27 pm

1 stop5h 12m

$471
Quickest round-trip

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sat 4/18

10:40 am-3:50 pm

1 stop5h 10m

Florence

Sun 4/19

4:16 pm-8:13 pm

1 stop3h 57m

$471

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sun 5/10

3:33 pm-9:47 pm

1 stop6h 14m

Florence

Sat 5/16

5:20 am-9:55 am

1 stop4h 35m

$472

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sat 4/18

4:50 pm-9:47 pm

1 stop4h 57m

Florence

Sun 4/19

4:16 pm-11:50 pm

2 stops7h 34m

$476

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Wed 4/15

11:41 am-3:50 pm

1 stop4h 09m

Florence

Wed 4/22

4:16 pm-9:58 pm

1 stop5h 42m

$477

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Wed 4/15

11:41 am-3:50 pm

1 stop4h 09m

Florence

Wed 4/22

4:16 pm-11:50 pm

2 stops7h 34m

$482

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Wed 4/15

7:00 am-3:50 pm

2 stops8h 50m

Florence

Wed 4/22

4:16 pm-11:50 pm

2 stops7h 34m

$487

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Fri 4/17

9:51 am-3:50 pm

1 stop5h 59m

Florence

Fri 4/24

4:16 pm-9:59 pm

1 stop5h 43m

$495

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Florida to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Florida to Florence, South Carolina flights?

You could potentially save up to 54% on your flight if you consider stops on a Florida to Florence, South Carolina flight.

Cheap Florida to Florence, South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florida to Florence, South Carolina

Fastest flight time

3h 50m

Direct flights

None
The fastest flight from Florida to Florence, South Carolina takes 3h 50m
There are no direct flights from Florida to Florence, South Carolina. There are no popular flight routes from Florida to Florence, South Carolina.
Search flight deals

  • When did momondo last update prices for flights from Florida to Florence Airport?

    Prices for flights from Florida to Florence Airport were last updated today.

  • How old do you have to be to fly from Florida to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Florida to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Lake City
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Florida to Florence?

Finding the right flight to Florence from Florida is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Florence quick and easy, saving you time and money.

Can I find flights from Florida to Florence with flexible booking policies on momondo?

All flight searches from Florida to Florence on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Florida to Florence?

momondo helps you find the best flight between Florida and Florence by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Florida to Florence right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Florence, momondo offers a useful price alert feature which will track prices for flights to Florence from Florida and alert you when they change.

An easier way to manage your Florence, South Carolina trip

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