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Cheap flights from Florence, South Carolina to Buffalo from $634

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Florence, South Carolina to Buffalo departing on 8/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Florence, South Carolina to Buffalo

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
3:22 pm - 9:55 pmFLO  Florence-BUF Buffalo
6h 33m1 stop Charlotte Douglas
American Airlines Logo
4:49 pm - 10:59 pmBUF  Buffalo-FLO Florence
6h 10m1 stop Charlotte Douglas
$634American Airlines
Sat, Aug 22 - Mon, Aug 24
American Airlines Logo
3:22 pm - 11:56 pmFLO  Florence-BUF Buffalo
8h 34m2 stops Charlotte Douglas Philadelphia
American Airlines Logo
6:59 pm - 10:59 pmBUF  Buffalo-FLO Florence
4h 00m1 stop Charlotte Douglas
$697American Airlines
Sat, Aug 22 - Mon, Aug 24
American Airlines Logo
6:22 am - 4:24 pmFLO  Florence-BUF Buffalo
10h 02m2 stops Charlotte Douglas Washington, D.C. Reagan-National
American Airlines Logo
5:00 am - 2:56 pmBUF  Buffalo-FLO Florence
9h 56m2 stops Washington, D.C. Reagan-National Charlotte Douglas
$829American Airlines
Sat, Aug 22 - Mon, Aug 24

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American Airlines flights from Florence, South Carolina to Buffalo

Our best American Airlines deals on Florence, South Carolina to Buffalo flight tickets
American Airlines
Aug 22
FLO3:22 pmFlorence
6h 33m
1 stop
BUF9:55 pmBuffalo
Aug 24
BUF4:49 pmBuffalo
6h 10m
1 stop
FLO10:59 pmFlorence
$634
American Airlines
Aug 22
FLO3:22 pmFlorence
8h 34m
2 stops
BUF11:56 pmBuffalo
Aug 24
BUF6:59 pmBuffalo
4h 00m
1 stop
FLO10:59 pmFlorence
$697
American Airlines
Aug 22
FLO6:22 amFlorence
10h 02m
2 stops
BUF4:24 pmBuffalo
Aug 24
BUF5:00 amBuffalo
9h 56m
2 stops
FLO2:56 pmFlorence
$829

momondo Fare Finder

 
Customize your flight search to find flights from Florence, South Carolina to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 11, 2026.
Use the filters below to find and compare flights from Florence, South Carolina to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

FlorenceBuffalo

FLO Florence - BUF Buffalo

FLOBUF

Florence

Sat 8/22

3:22 pm-9:55 pm

1 stop6h 33m

Buffalo

Mon 8/24

4:49 pm-10:59 pm

1 stop6h 10m

$634
Quickest round-trip

FlorenceBuffalo

FLO Florence - BUF Buffalo

FLOBUF

Florence

Sat 8/22

3:22 pm-11:56 pm

2 stops8h 34m

Buffalo

Mon 8/24

6:59 pm-10:59 pm

1 stop4h 00m

$697

FlorenceBuffalo

FLO Florence - BUF Buffalo

FLOBUF

Florence

Sat 8/22

6:22 am-4:24 pm

2 stops10h 02m

Buffalo

Mon 8/24

5:00 am-2:56 pm

2 stops9h 56m

$829

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

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How to get the cheapest flight ticket from Florence, South Carolina to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Buffalo?

American Airlines, Breeze Airways and Delta are the top three most popular airlines that fly to Buffalo from Florence, South Carolina according to our data. American Airlines is the first choice among our users, with 76% of people opting to fly with this airline when traveling to Buffalo. Keep in mind that there are 7 different airlines that fly to Buffalo on a routine basis, so you have a few additional options to choose from.

When to book flights from Florence, South Carolina to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Florence, South Carolina to Buffalo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Florence, South Carolina to Buffalo (FLO to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florence, South Carolina to Buffalo

Fastest flight time

6h 33m

Direct flights

None
The fastest flight from Florence, South Carolina to Buffalo takes 6h 33m
There are no direct flights from Florence, South Carolina to Buffalo. There are no popular flight routes from Florence, South Carolina to Buffalo.
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Frequently asked questions about flying from Florence, South Carolina to Buffalo

  • How far is Florence to Buffalo by plane?

    Buffalo is 602.0 mi away from Florence. A reasonable flight in good conditions will take 6h 33m.

  • When did momondo last update prices for flights from Florence Airport to Buffalo Airport?

    Prices for flights from Florence Airport to Buffalo Airport are updated daily.

  • How old do you have to be to fly from Florence Airport to Buffalo Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Florence Airport to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The required travel and health documents for your Buffalo Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Buffalo Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Amherst
Tonawanda
Williamsville
Orchard Park
Grand Island
Bowmansville
West Seneca
Lockport
East Aurora
Angola

Why use momondo?

Why should I use momondo to find a flight deal from Florence to Buffalo?

It is quick and easy to find Florence to Buffalo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Buffalo that suits you.

Can I find flights from Florence to Buffalo with flexible booking policies on momondo?

Yes. All flights to Buffalo from Florence on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Florence to Buffalo?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Buffalo from Florence.

I’m not ready to book a flight from Florence to Buffalo right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Florence to Buffalo flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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