Latest deals
Insights
When to book
FAQs
Price Alerts

Cheap flights from Florence, South Carolina to Buffalo from $534

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Florence, South Carolina to Buffalo departing on 4/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Florence, South Carolina to Buffalo

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:15 am - 12:46 pm
FLO
-
BUF
6h 31m
1 stop
American Airlines Logo
12:29 pm - 9:47 pm
BUF
-
FLO
9h 18m
2 stops
$534American Airlines
Tue, Apr 7 - Sat, Apr 11
American Airlines Logo
4:02 pm - 11:39 pm
FLO
-
BUF
7h 37m
2 stops
American Airlines Logo
12:29 pm - 9:47 pm
BUF
-
FLO
9h 18m
2 stops
$539American Airlines
Tue, Apr 7 - Sat, Apr 11
American Airlines Logo
2:35 pm - 6:41 pm
FLO
-
BUF
4h 06m
1 stop
American Airlines Logo
5:25 am - 2:10 pm
BUF
-
FLO
8h 45m
2 stops
$566American Airlines
Fri, Jun 26 - Mon, Jun 29
American Airlines Logo
2:35 pm - 9:23 pm
FLO
-
BUF
6h 48m
2 stops
American Airlines Logo
6:02 am - 2:10 pm
BUF
-
FLO
8h 08m
2 stops
$629American Airlines
Thu, Jun 25 - Wed, Jul 1
American Airlines Logo
2:35 pm - 9:23 pm
FLO
-
BUF
6h 48m
2 stops
American Airlines Logo
6:02 am - 2:10 pm
BUF
-
FLO
8h 08m
2 stops
$635American Airlines
Thu, Jun 25 - Mon, Jun 29
American Airlines Logo
2:35 pm - 6:39 pm
FLO
-
BUF
4h 04m
1 stop
American Airlines Logo
6:02 am - 2:10 pm
BUF
-
FLO
8h 08m
2 stops
$643American Airlines
Sat, Jun 27 - Wed, Jul 1
American Airlines Logo
5:05 am - 4:25 pm
FLO
-
BUF
11h 20m
2 stops
American Airlines Logo
5:25 am - 2:10 pm
BUF
-
FLO
8h 45m
2 stops
$647American Airlines
Fri, Jun 26 - Mon, Jun 29
American Airlines Logo
2:35 pm - 6:39 pm
FLO
-
BUF
4h 04m
1 stop
American Airlines Logo
6:02 am - 2:10 pm
BUF
-
FLO
8h 08m
2 stops
$649American Airlines
Sat, Jun 27 - Mon, Jun 29
American Airlines Logo
2:35 pm - 6:41 pm
FLO
-
BUF
4h 06m
1 stop
American Airlines Logo
6:25 am - 10:00 pm
BUF
-
FLO
15h 35m
1 stop
$683American Airlines
Fri, Jun 26 - Mon, Jun 29
American Airlines Logo
2:35 pm - 6:41 pm
FLO
-
BUF
4h 06m
1 stop
American Airlines Logo
6:02 am - 2:10 pm
BUF
-
FLO
8h 08m
2 stops
$694American Airlines
Thu, Jun 25 - Wed, Jul 1

American Airlines flights from Florence, South Carolina to Buffalo

Our best American Airlines deals on Florence, South Carolina to Buffalo flight tickets
American Airlines
Apr 7
FLO6:15 amFlorence
6h 31m
1 stop
BUF12:46 pmBuffalo
Apr 11
BUF12:29 pmBuffalo
9h 18m
2 stops
FLO9:47 pmFlorence
$534
American Airlines
Apr 7
FLO4:02 pmFlorence
7h 37m
2 stops
BUF11:39 pmBuffalo
Apr 11
BUF12:29 pmBuffalo
9h 18m
2 stops
FLO9:47 pmFlorence
$539
American Airlines
Jun 26
FLO2:35 pmFlorence
4h 06m
1 stop
BUF6:41 pmBuffalo
Jun 29
BUF5:25 amBuffalo
8h 45m
2 stops
FLO2:10 pmFlorence
$566

momondo Fare Finder

 
Customize your flight search to find flights from Florence, South Carolina to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 23, 2026.
Use the filters below to find and compare flights from Florence, South Carolina to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Tue 4/7

6:15 am-12:46 pm

1 stop6h 31m

Buffalo

Sat 4/11

12:29 pm-9:47 pm

2 stops9h 18m

$534

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Tue 4/7

4:02 pm-11:39 pm

2 stops7h 37m

Buffalo

Sat 4/11

12:29 pm-9:47 pm

2 stops9h 18m

$539

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Fri 6/26

2:35 pm-6:41 pm

1 stop4h 06m

Buffalo

Mon 6/29

5:25 am-2:10 pm

2 stops8h 45m

$566

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Thu 6/25

2:35 pm-9:23 pm

2 stops6h 48m

Buffalo

Wed 7/1

6:02 am-2:10 pm

2 stops8h 08m

$629

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Thu 6/25

2:35 pm-9:23 pm

2 stops6h 48m

Buffalo

Mon 6/29

6:02 am-2:10 pm

2 stops8h 08m

$635
Quickest round-trip

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Sat 6/27

2:35 pm-6:39 pm

1 stop4h 04m

Buffalo

Wed 7/1

6:02 am-2:10 pm

2 stops8h 08m

$643

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Fri 6/26

5:05 am-4:25 pm

2 stops11h 20m

Buffalo

Mon 6/29

5:25 am-2:10 pm

2 stops8h 45m

$647

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Sat 6/27

2:35 pm-6:39 pm

1 stop4h 04m

Buffalo

Mon 6/29

6:02 am-2:10 pm

2 stops8h 08m

$649

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Fri 6/26

2:35 pm-6:41 pm

1 stop4h 06m

Buffalo

Mon 6/29

6:25 am-10:00 pm

1 stop15h 35m

$683

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Thu 6/25

2:35 pm-6:41 pm

1 stop4h 06m

Buffalo

Wed 7/1

6:02 am-2:10 pm

2 stops8h 08m

$694

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Buffalo from

How to get the cheapest flight ticket from Florence, South Carolina to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Buffalo?

American Airlines, Delta and Breeze Airways are the top three most popular airlines that fly to Buffalo from Florence, South Carolina according to our data. American Airlines is the first choice among our users, with 79% of people opting to fly with this airline when traveling to Buffalo. Keep in mind that there are 9 different airlines that fly to Buffalo on a routine basis, so you have a few additional options to choose from.

When to book flights from Florence, South Carolina to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Florence, South Carolina to Buffalo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Florence, South Carolina to Buffalo (FLO to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florence, South Carolina to Buffalo

Fastest flight time

4h 06m

Direct flights

None
The fastest flight from Florence, South Carolina to Buffalo takes 4h 06m
There are no direct flights from Florence, South Carolina to Buffalo. There are no popular flight routes from Florence, South Carolina to Buffalo.
Search flight deals

  • How far is Florence to Buffalo by plane?

    Buffalo is 602.0 mi away from Florence. A reasonable flight in good conditions will take 4h 06m.

  • When did momondo last update prices for flights from Florence Airport to Buffalo Airport?

    Prices for flights from Florence Airport to Buffalo Airport are updated daily.

  • How old do you have to be to fly from Florence Airport to Buffalo Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Florence Airport to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The required travel and health documents for your Buffalo Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Buffalo Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Amherst
Grand Island
Tonawanda
Orchard Park
Williamsville
Lockport
West Seneca
Bowmansville
East Aurora
Eden
Angola

Why use momondo?

Why should I use momondo to find a flight deal from Florence to Buffalo?

It is quick and easy to find Florence to Buffalo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Buffalo that suits you.

Can I find flights from Florence to Buffalo with flexible booking policies on momondo?

Yes. All flights to Buffalo from Florence on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Florence to Buffalo?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Buffalo from Florence.

I’m not ready to book a flight from Florence to Buffalo right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Florence to Buffalo flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Buffalo trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Wed 4/22
Wed 4/29
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States