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Cheap flights from Florence, South Carolina to Buffalo from $335

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Florence, South Carolina to Buffalo departing on 3/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Florence, South Carolina to Buffalo

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:58 pm - 10:58 am
FLO
-
BUF
17h 00m
2 stops
American Airlines Logo
11:28 am - 11:57 pm
BUF
-
FLO
12h 29m
2 stops
$395American Airlines
Tue, Feb 17 - Sat, Feb 21
American Airlines Logo
5:58 pm - 11:38 pm
FLO
-
BUF
5h 40m
1 stop
American Airlines Logo
11:28 am - 11:57 pm
BUF
-
FLO
12h 29m
2 stops
$452American Airlines
Tue, Feb 17 - Sat, Feb 21
American Airlines Logo
5:58 pm - 11:38 pm
FLO
-
BUF
5h 40m
1 stop
American Airlines Logo
1:35 pm - 5:50 pm
BUF
-
FLO
4h 15m
1 stop
$489American Airlines
Tue, Feb 17 - Sat, Feb 21

American Airlines flights from Florence, South Carolina to Buffalo

Our best American Airlines deals on Florence, South Carolina to Buffalo flight tickets
American Airlines
Feb 17
FLO5:58 pmFlorence
17h 00m
2 stops
BUF10:58 amBuffalo
Feb 21
BUF11:28 amBuffalo
12h 29m
2 stops
FLO11:57 pmFlorence
$395
American Airlines
Feb 17
FLO5:58 pmFlorence
5h 40m
1 stop
BUF11:38 pmBuffalo
Feb 21
BUF11:28 amBuffalo
12h 29m
2 stops
FLO11:57 pmFlorence
$452
American Airlines
Feb 17
FLO5:58 pmFlorence
5h 40m
1 stop
BUF11:38 pmBuffalo
Feb 21
BUF1:35 pmBuffalo
4h 15m
1 stop
FLO5:50 pmFlorence
$489

momondo Fare Finder

 
Customize your flight search to find flights from Florence, South Carolina to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Florence, South Carolina to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Tue 2/17

5:58 pm-10:58 am

2 stops17h 00m

Buffalo

Sat 2/21

11:28 am-11:57 pm

2 stops12h 29m

$395

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Tue 2/17

5:58 pm-11:38 pm

1 stop5h 40m

Buffalo

Sat 2/21

11:28 am-11:57 pm

2 stops12h 29m

$452

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Tue 2/17

5:58 pm-11:38 pm

1 stop5h 40m

Buffalo

Sat 2/21

1:35 pm-5:50 pm

1 stop4h 15m

$489

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Fri 3/13

5:16 am-5:29 pm

2 stops12h 13m

$335

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Sat 3/14

6:25 pm-11:49 am

2 stops17h 24m

$343

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Tue 5/19

4:02 pm-2:21 pm

2 stops22h 19m

$371

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Sat 3/14

6:25 pm-11:50 pm

1 stop5h 25m

$383

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Wed 5/20

4:16 pm-10:04 pm

2 stops5h 48m

$388

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Fri 3/13

6:20 pm-11:50 pm

1 stop5h 30m

$413

FlorenceBuffalo

FLO - BUF

FLOBUF

Florence

Mon 5/18

4:16 pm-11:39 pm

2 stops7h 23m

$418

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Buffalo from

How to get the cheapest flight ticket from Florence, South Carolina to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Florence to Buffalo?

American Airlines is the most popular carrier operating from Florence to Buffalo

What airlines fly to Buffalo?

American Airlines, Delta and Southwest are the top three most popular airlines that fly to Buffalo from Florence, South Carolina according to our data. American Airlines is the first choice among our users, with 78% of people opting to fly with this airline when traveling to Buffalo. Keep in mind that there are 9 different airlines that fly to Buffalo on a routine basis, so you have a few additional options to choose from.

When to book flights from Florence, South Carolina to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Florence, South Carolina to Buffalo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Florence, South Carolina to Buffalo (FLO to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Florence, South Carolina to Buffalo

Fastest flight time

17h 00m

Direct flights

None
The fastest flight from Florence, South Carolina to Buffalo takes 17h 00m
There are no direct flights from Florence, South Carolina to Buffalo. There are no popular flight routes from Florence, South Carolina to Buffalo.
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  • How far is Florence to Buffalo by plane?

    Buffalo is 602.0 mi away from Florence. A reasonable flight in good conditions will take 17h 00m.

  • When did momondo last update prices for flights from Florence Airport to Buffalo Airport?

    Prices for flights from Florence Airport to Buffalo Airport are updated daily.

  • How old do you have to be to fly from Florence Airport to Buffalo Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Florence Airport to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The required travel and health documents for your Buffalo Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Buffalo Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Amherst
Grand Island
Tonawanda
Williamsville
Orchard Park
Lockport
West Seneca
Bowmansville
East Aurora
Eden
Angola

Why use momondo?

Why should I use momondo to find a flight deal from Florence to Buffalo?

It is quick and easy to find Florence to Buffalo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Buffalo that suits you.

Can I find flights from Florence to Buffalo with flexible booking policies on momondo?

Yes. All flights to Buffalo from Florence on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Florence to Buffalo?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Buffalo from Florence.

I’m not ready to book a flight from Florence to Buffalo right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Florence to Buffalo flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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