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Cheap flights from Des Moines to Missouri from $59

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Missouri departing on 2/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Missouri

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:51 pm - 10:55 pm
DSM
-
STL
5h 04m1 stop
American Airlines Logo
11:55 am - 5:06 pm
STL
-
DSM
5h 11m1 stop
$181American Airlines
Thu, Jan 15 - Sat, Jan 17
Delta Logo
10:59 am - 8:43 pm
DSM
-
STL
9h 44m2 stops
Delta Logo
10:19 am - 5:08 pm
STL
-
DSM
6h 49m1 stop
$186Delta
Sat, Jan 24 - Sat, Jan 31
Southwest Logo
8:35 am - 1:55 pm
DSM
-
STL
5h 20m1 stop
Southwest Logo
3:00 pm - 9:20 pm
STL
-
DSM
6h 20m1 stop
$233Southwest
Wed, Jan 7 - Sun, Jan 11
Southwest Logo
8:35 am - 1:55 pm
DSM
-
STL
5h 20m1 stop
Southwest Logo
12:20 pm - 9:20 pm
STL
-
DSM
9h 00m2 stops
$238Southwest
Wed, Jan 7 - Sun, Jan 11
United Airlines Logo
3:35 pm - 9:13 pm
DSM
-
STL
5h 38m1 stop
United Airlines Logo
8:05 am - 2:33 pm
STL
-
DSM
6h 28m1 stop
$241United Airlines
Sat, Jan 17 - Wed, Jan 21
Southwest Logo
11:30 am - 8:15 pm
DSM
-
STL
8h 45m1 stop
Southwest Logo
1:45 pm - 2:55 pm
STL
-
DSM
1h 10mnonstop
$250Southwest
Thu, Jan 15 - Sat, Jan 17
American Airlines Logo
6:40 am - 1:36 pm
DSM
-
STL
6h 56m1 stop
American Airlines Logo
11:55 am - 5:06 pm
STL
-
DSM
5h 11m1 stop
$255American Airlines
Wed, Dec 31 - Wed, Jan 7
Multiple Airlines Logo
3:53 pm - 8:52 am
DSM
-
MCI
16h 59m1 stop
Multiple Airlines Logo
11:26 am - 10:46 pm
MCI
-
DSM
11h 20m1 stop
$262Multiple Airlines
Sun, Jan 25 - Sun, Feb 1
Multiple Airlines Logo
3:53 pm - 8:52 am
DSM
-
MCI
16h 59m1 stop
Multiple Airlines Logo
11:26 am - 10:46 pm
MCI
-
DSM
11h 20m1 stop
$263Multiple Airlines
Sun, Jan 25 - Sun, Feb 1
United Airlines Logo
8:00 am - 2:30 pm
DSM
-
STL
6h 30m1 stop
United Airlines Logo
9:57 am - 2:33 pm
STL
-
DSM
4h 36m1 stop
$266United Airlines
Fri, Jan 9 - Sat, Jan 10

American Airlines flights from Des Moines to Missouri

Our best American Airlines deals on Des Moines to Missouri flight tickets
American Airlines
Jan 15
DSM5:51 pmDes Moines
5h 04m
1 stop
STL10:55 pmLambert-St Louis
Jan 17
STL11:55 amLambert-St Louis
5h 11m
1 stop
DSM5:06 pmDes Moines
$181
Find similar
American Airlines
Dec 31
DSM6:40 amDes Moines
6h 56m
1 stop
STL1:36 pmLambert-St Louis
Jan 7
STL11:55 amLambert-St Louis
5h 11m
1 stop
DSM5:06 pmDes Moines
$255
Find similar
American Airlines
Dec 25
DSM6:40 amDes Moines
7h 29m
1 stop
STL2:09 pmLambert-St Louis
Dec 29
STL8:01 pmLambert-St Louis
3h 45m
1 stop
DSM11:46 pmDes Moines
$428
Find similar

United Airlines flights from Des Moines to Missouri

Our best United Airlines deals on Des Moines to Missouri flight tickets
United Airlines
Jan 17
DSM3:35 pmDes Moines
5h 38m
1 stop
STL9:13 pmLambert-St Louis
Jan 21
STL8:05 amLambert-St Louis
6h 28m
1 stop
DSM2:33 pmDes Moines
$241
Find similar
United Airlines
Jan 9
DSM8:00 amDes Moines
6h 30m
1 stop
STL2:30 pmLambert-St Louis
Jan 10
STL9:57 amLambert-St Louis
4h 36m
1 stop
DSM2:33 pmDes Moines
$266
Find similar
United Airlines
Jan 16
DSM8:00 amDes Moines
6h 30m
1 stop
STL2:30 pmLambert-St Louis
Jan 19
STL4:49 pmLambert-St Louis
5h 01m
1 stop
DSM9:50 pmDes Moines
$296
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 11, 2025.
Use the filters below to find and compare flights from Des Moines to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 1/15

5:51 pm-10:55 pm

1 stop5h 04m

Lambert-St Louis

Sat 1/17

11:55 am-5:06 pm

1 stop5h 11m

$181

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 1/24

10:59 am-8:43 pm

2 stops9h 44m

Lambert-St Louis

Sat 1/31

10:19 am-5:08 pm

1 stop6h 49m

$186

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 1/7

8:35 am-1:55 pm

1 stop5h 20m

Lambert-St Louis

Sun 1/11

3:00 pm-9:20 pm

1 stop6h 20m

$233

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 1/7

8:35 am-1:55 pm

1 stop5h 20m

Lambert-St Louis

Sun 1/11

12:20 pm-9:20 pm

2 stops9h 00m

$238

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 1/17

3:35 pm-9:13 pm

1 stop5h 38m

Lambert-St Louis

Wed 1/21

8:05 am-2:33 pm

1 stop6h 28m

$241

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 1/15

11:30 am-8:15 pm

1 stop8h 45m

Lambert-St Louis

Sat 1/17

1:45 pm-2:55 pm

Nonstop1h 10m

$250

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 12/31

6:40 am-1:36 pm

1 stop6h 56m

Lambert-St Louis

Wed 1/7

11:55 am-5:06 pm

1 stop5h 11m

$255

Des MoinesKansas City

DSM - MCI

DSMMCI

Des Moines

Sun 1/25

3:53 pm-8:52 am

1 stop16h 59m

Kansas City

Sun 2/1

11:26 am-10:46 pm

1 stop11h 20m

$262

Des MoinesKansas City

DSM - MCI

DSMMCI

Des Moines

Sun 1/25

3:53 pm-8:52 am

1 stop16h 59m

Kansas City

Sun 2/1

11:26 am-10:46 pm

1 stop11h 20m

$263

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 1/9

8:00 am-2:30 pm

1 stop6h 30m

Lambert-St Louis

Sat 1/10

9:57 am-2:33 pm

1 stop4h 36m

$266

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Missouri from

How to get the cheapest flight ticket from Des Moines to Missouri

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Missouri?

The cheapest day to depart from Des Moines to Missouri is on a Wednesday when prices can be found for as low as $368. Flights from Des Moines to Missouri on a Saturday will generally be more expensive and average around $428. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Missouri?

According to our data, the cheapest time of day to fly to Missouri is in the afternoon. momondo users have found flights departing from Des Moines to Missouri in the afternoon for as low as $388. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Missouri are more costly in the morning, with an average ticket price of $411. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Des Moines to Missouri flight route?

Fly from Des Moines to Lambert-St Louis for the best Des Moines - Missouri flight prices

What cabin class options are available on Des Moines to Missouri flights?

There is only 1 cabin class available to choose from on Des Moines to Missouri flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to Missouri flights?

No. A direct flight is the cheapest option for a flight between Des Moines to Missouri.

Cheap Des Moines to Missouri flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Missouri

Best Price Found

$186

Fastest flight time

1h 05m

Direct flights

Wed, Thu, Sat and Sun

Airports in Missouri

55 airports
The best one-way flight to Missouri from Des Moines in the past 72 hours is $186. The best round-trip flight deal from Des Moines to Missouri found on momondo in the last 72 hours is $340.
The fastest flight from Des Moines to Missouri takes 1h 05m
Direct flights go from Des Moines to Missouri on Wednesday, Thursday, Saturday and Sunday. There are no airlines offering direct flights.
There are 55 airports in Missouri. From Des Moines there are direct flights to Lambert-St Louis (STL).
Search flight deals

  • When did momondo last update prices for flights from Des Moines Airport to Missouri?

    Prices for flights from Des Moines Airport to Missouri refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Missouri?

  • How old do you have to be to fly from Des Moines Airport to Missouri?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Missouri.

  • What documentation or ID do you need to fly to Missouri?

    The necessary travel and health documents for your Missouri trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Des Moines to Missouri?

Best airlines flying from Des Moines to Missouri

Compare and see reviews for airlines that fly from Des Moines to Missouri with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $97Free CancellationRating
7.9
4,253 reviews
Search Southwest flights
American AirlinesPriceFrom $218Free CancellationRating
7.2
11,050 reviews
Search American Airlines flights
United AirlinesPriceFrom $218Free CancellationRating
7.4
9,095 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Missouri?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Missouri for you.

Can I find flights from Des Moines to Missouri with flexible booking policies on momondo?

Yes. All flights to Missouri from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Missouri?

momondo helps you find the best flight between Des Moines and Missouri by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Missouri right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Missouri flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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