What is the cheapest airline that flies from Des Moines to Missouri?

Southwest, United Airlines, and Frontier are the most popular carriers operating from Des Moines to Missouri

When did momondo last update prices for flights from Des Moines Airport to Missouri?

Prices for flights from Des Moines Airport to Missouri refresh daily.

How many operators does momondo search for flights from Des Moines Airport to Missouri?

There are 2 operators available for flights from Des Moines Airport to Missouri as of May 2026.

How old do you have to be to fly from Des Moines Airport to Missouri?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Missouri.

What documentation or ID do you need to fly to Missouri?

The necessary travel and health documents for your Missouri trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$145 Cheap Flights from Des Moines to Missouri in 2026

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Find the cheapest flights from Des Moines to Missouri

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

10:54 am - 4:46 pm

DSM

STL

5h 52m

1 stop

6:20 am - 10:18 am

STL

DSM

3h 58m

1 stop

$293Delta

Tue, Jul 28 - Wed, Aug 5

6:00 am - 6:36 pm

DSM

STL

12h 36m

2 stops

7:03 pm - 12:59 pm

STL

DSM

17h 56m

1 stop

$297Multiple Airlines

Sun, Aug 2 - Tue, Aug 4

10:54 am - 3:13 pm

DSM

STL

4h 19m

1 stop

6:20 am - 10:18 am

STL

DSM

3h 58m

1 stop

$305Delta

Tue, Jul 28 - Mon, Aug 3

5:20 am - 2:45 pm

DSM

STL

9h 25m

2 stops

5:50 am - 11:25 am

STL

DSM

5h 35m

1 stop

$310Southwest

Wed, Jul 1 - Sun, Jul 5

3:24 pm - 9:26 pm

DSM

STL

6h 02m

1 stop

6:00 am - 10:17 am

STL

DSM

4h 17m

1 stop

$313United Airlines

Mon, Jul 27 - Wed, Jul 29

6:00 am - 6:36 pm

DSM

STL

12h 36m

2 stops

7:03 pm - 8:54 pm

STL

DSM

25h 51m

1 stop

$314Multiple Airlines

Sun, Aug 2 - Wed, Aug 5

6:00 am - 6:36 pm

DSM

STL

12h 36m

2 stops

7:03 pm - 12:59 pm

STL

DSM

17h 56m

1 stop

$316Multiple Airlines

Thu, Jul 30 - Tue, Aug 4

4:48 pm - 11:59 pm

DSM

STL

7h 11m

1 stop

7:55 pm - 12:01 am

STL

DSM

4h 06m

1 stop

$317American Airlines

Sat, Jun 27 - Sun, Jul 5

6:40 pm - 11:10 pm

DSM

MCI

4h 30m

1 stop

9:50 am - 1:55 pm

MCI

DSM

4h 05m

1 stop

$347Southwest

Tue, Sep 22 - Wed, Sep 23

10:59 am - 9:50 am

DSM

MCI

46h 51m

2 stops

6:57 pm - 10:15 pm

MCI

DSM

27h 18m

1 stop

$427Allegiant Air

Wed, Jul 8 - Sun, Jul 12

United Airlines flights from Des Moines to Missouri

Our best United Airlines deals on Des Moines to Missouri flight tickets

United Airlines

Jul 27

DSM3:24 pmDes Moines

6h 02m

1 stop

STL9:26 pmLambert-St Louis

Jul 29

STL6:00 amLambert-St Louis

4h 17m

1 stop

DSM10:17 amDes Moines

$313

United Airlines

Jun 30

DSM6:52 pmDes Moines

4h 37m

1 stop

STL11:29 pmLambert-St Louis

Jul 1

STL7:20 amLambert-St Louis

7h 07m

1 stop

DSM2:27 pmDes Moines

$363

United Airlines

Jun 9

DSM6:00 amDes Moines

6h 11m

1 stop

STL12:11 pmLambert-St Louis

Jun 10

STL6:00 amLambert-St Louis

4h 30m

1 stop

DSM10:30 amDes Moines

$389

Southwest flights from Des Moines to Missouri

Our best Southwest deals on Des Moines to Missouri flight tickets

Southwest

Jul 1

DSM5:20 amDes Moines

9h 25m

2 stops

STL2:45 pmLambert-St Louis

Jul 5

STL5:50 amLambert-St Louis

5h 35m

1 stop

DSM11:25 amDes Moines

$310

Southwest

Jul 4

DSM6:10 amDes Moines

8h 35m

2 stops

STL2:45 pmLambert-St Louis

Jul 11

STL5:40 amLambert-St Louis

5h 55m

1 stop

DSM11:35 amDes Moines

$326

Southwest

Sep 7

DSM5:40 amDes Moines

9h 40m

2 stops

STL3:20 pmLambert-St Louis

Sep 9

STL3:05 pmLambert-St Louis

6h 50m

2 stops

DSM9:55 pmDes Moines

$329

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 7/28

10:54 am-4:46 pm

1 stop5h 52m

Lambert-St Louis

Wed 8/5

6:20 am-10:18 am

1 stop3h 58m

$293

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sun 8/2

6:00 am-6:36 pm

2 stops12h 36m

Lambert-St Louis

Tue 8/4

7:03 pm-12:59 pm

1 stop17h 56m

$297

Quickest round-trip

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 7/28

10:54 am-3:13 pm

1 stop4h 19m

Lambert-St Louis

Mon 8/3

6:20 am-10:18 am

1 stop3h 58m

$305

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 7/1

5:20 am-2:45 pm

2 stops9h 25m

Lambert-St Louis

Sun 7/5

5:50 am-11:25 am

1 stop5h 35m

$310

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 7/27

3:24 pm-9:26 pm

1 stop6h 02m

Lambert-St Louis

Wed 7/29

6:00 am-10:17 am

1 stop4h 17m

$313

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sun 8/2

6:00 am-6:36 pm

2 stops12h 36m

Lambert-St Louis

Wed 8/5

7:03 pm-8:54 pm

1 stop25h 51m

$314

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 7/30

6:00 am-6:36 pm

2 stops12h 36m

Lambert-St Louis

Tue 8/4

7:03 pm-12:59 pm

1 stop17h 56m

$316

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 6/27

4:48 pm-11:59 pm

1 stop7h 11m

Lambert-St Louis

Sun 7/5

7:55 pm-12:01 am

1 stop4h 06m

$317

Des MoinesKansas City

DSM - MCI

DSMMCI

Des Moines

Tue 9/22

6:40 pm-11:10 pm

1 stop4h 30m

Kansas City

Wed 9/23

9:50 am-1:55 pm

1 stop4h 05m

$347

Des MoinesKansas City

DSM - MCI

DSMMCI

Des Moines

Wed 7/8

10:59 am-9:50 am

2 stops46h 51m

Kansas City

Sun 7/12

6:57 pm-10:15 pm

1 stop27h 18m

$427

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Missouri

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Missouri?

In general, November is the cheapest month to fly from Des Moines to Missouri. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $0. If you aren’t able to travel to Missouri during the month of November, then flying in May is also cheap. Prices for this month can be found on momondo for an average of $70.

What is the cheapest day to depart on your flight to Missouri?

The cheapest day to depart from Des Moines to Missouri is on a Tuesday when prices can be found for as low as $356. Flights from Des Moines to Missouri on a Friday will generally be more expensive and average around $409. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Missouri?

According to our data, the cheapest time of day to fly to Missouri is in the afternoon. momondo users have found flights departing from Des Moines to Missouri in the afternoon for as low as $360. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Missouri are more costly in the morning, with an average ticket price of $389. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Des Moines to Missouri flight route?

Fly from Des Moines to Lambert-St Louis for the best Des Moines - Missouri flight prices

What cabin class options are available on Des Moines to Missouri flights?

There is only 1 cabin class available to choose from on Des Moines to Missouri flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to Missouri flights?

No. A direct flight is the cheapest option for a flight between Des Moines to Missouri.

Cheap Des Moines to Missouri flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Missouri

Best Price Found	$462
Fastest flight time	3h 28m
Direct flights	None

The best flight deal from Des Moines to Missouri found on momondo in the last 72 hours is $462

The fastest flight from Des Moines to Missouri takes 3h 28m

There are no direct flights from Des Moines to Missouri. Popular non-direct route for this connection is Des Moines Airport - Lambert-St Louis Airport.

Search flight deals

Frequently asked questions about flying from Des Moines to Missouri

When did momondo last update prices for flights from Des Moines Airport to Missouri?
Prices for flights from Des Moines Airport to Missouri refresh daily.
How many operators does momondo search for flights from Des Moines Airport to Missouri?
There are 2 operators available for flights from Des Moines Airport to Missouri as of May 2026.
How old do you have to be to fly from Des Moines Airport to Missouri?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Missouri.
What documentation or ID do you need to fly to Missouri?
The necessary travel and health documents for your Missouri trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular plane model from Des Moines to Missouri?
Based on momondo bookings for this flight route, the most popular plane model on flight routes from Des Moines to Missouri is Airbus A320-100/200 (22.58% of total bookings). The next most popular plane models are Airbus A319 (19.35%), Boeing 737 MAX 8 (11.29%), and Airbus A320neo (11.29%).

Best airlines flying from Des Moines to Missouri

Compare and see reviews for airlines that fly from Des Moines to Missouri with momondo

Airline	Rating	Free Cancellation	Price
Southwest	PriceFrom $97	Free Cancellation	Rating 7.9 4,270 reviews		Search Southwest flights
American Airlines	PriceFrom $158	Free Cancellation	Rating 7.1 11,631 reviews		Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Missouri?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Missouri for you.

Can I find flights from Des Moines to Missouri with flexible booking policies on momondo?

Yes. All flights to Missouri from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Missouri?

momondo helps you find the best flight between Des Moines and Missouri by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Missouri right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Missouri flights. All you need is a valid email address and we will do the rest; it is that quick and easy.