What is the cheapest airline that flies from Des Moines to Missouri?

Southwest, Delta, and Frontier are the most popular carriers operating from Des Moines to Missouri

What airlines fly to Missouri?

Southwest, American Airlines and United Airlines are the top three most popular airlines that fly to Missouri from Des Moines according to our data. Southwest is the first choice among our users, with 59% of people opting to fly with this airline when traveling to Missouri. Keep in mind that there are 3 different airlines that fly to Missouri on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Des Moines Airport to Missouri?

Prices for flights from Des Moines Airport to Missouri refresh daily.

How many operators does momondo search for flights from Des Moines Airport to Missouri?

There is 1 operator available for flights from Des Moines Airport to Missouri as of April 2026.

How old do you have to be to fly from Des Moines Airport to Missouri?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Missouri.

What documentation or ID do you need to fly to Missouri?

The necessary travel and health documents for your Missouri trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$70 Cheap Flights from Des Moines to Missouri in 2026

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Not ready to book? to track prices.

Search flight deals

Find the cheapest flights from Des Moines to Missouri

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

5:30 am - 11:30 am

DSM

STL

6h 00m

1 stop

3:55 pm - 9:15 pm

STL

DSM

5h 20m

1 stop

$279Southwest

Wed, Apr 29 - Wed, May 6

5:30 am - 9:30 am

DSM

STL

4h 00m

1 stop

3:10 pm - 10:10 pm

STL

DSM

7h 00m

2 stops

$284Southwest

Wed, Apr 29 - Wed, May 6

5:30 am - 11:30 am

DSM

STL

6h 00m

1 stop

5:40 am - 11:30 am

STL

DSM

5h 50m

1 stop

$288Southwest

Tue, Apr 21 - Sat, Apr 25

5:30 am - 3:15 pm

DSM

STL

9h 45m

2 stops

3:10 pm - 10:10 pm

STL

DSM

7h 00m

2 stops

$289Southwest

Wed, Apr 29 - Wed, May 6

5:30 am - 3:15 pm

DSM

STL

9h 45m

2 stops

5:40 am - 11:30 am

STL

DSM

5h 50m

1 stop

$293Southwest

Tue, Apr 21 - Sat, Apr 25

4:00 pm - 9:29 pm

DSM

STL

5h 29m

1 stop

5:36 pm - 9:03 pm

STL

DSM

3h 27m

1 stop

$297Delta

Sat, May 16 - Sat, May 23

11:57 am - 6:00 pm

DSM

STL

6h 03m

1 stop

6:45 am - 3:44 pm

STL

DSM

8h 59m

2 stops

$302Delta

Sat, May 16 - Sat, May 23

9:06 am - 8:41 pm

DSM

MCI

11h 35m

1 stop

8:49 am - 8:16 pm

MCI

DSM

11h 27m

1 stop

$614United Airlines

Sat, May 9 - Wed, May 13

7:06 pm - 1:07 pm

DSM

MCI

18h 01m

1 stop

9:05 am - 12:12 am

MCI

DSM

15h 07m

1 stop

$616American Airlines

Mon, Jun 8 - Sat, Jun 13

5:30 am - 8:41 pm

DSM

MCI

15h 11m

1 stop

6:00 am - 4:15 pm

MCI

DSM

10h 15m

1 stop

$623United Airlines

Sat, May 9 - Wed, May 13

Delta flights from Des Moines to Missouri

Our best Delta deals on Des Moines to Missouri flight tickets

Delta

Apr 16

DSM6:31 pmDes Moines

5h 05m

1 stop

STL11:36 pmLambert-St Louis

Apr 23

STL6:20 amLambert-St Louis

3h 56m

1 stop

DSM10:16 amDes Moines

$311

Delta

May 29

DSM6:41 pmDes Moines

5h 18m

1 stop

STL11:59 pmLambert-St Louis

May 31

STL6:21 amLambert-St Louis

6h 03m

1 stop

DSM12:24 pmDes Moines

$317

Delta

Apr 14

DSM7:00 amDes Moines

6h 05m

2 stops

STL1:05 pmLambert-St Louis

Apr 18

STL6:48 amLambert-St Louis

8h 53m

2 stops

DSM3:41 pmDes Moines

$335

United Airlines flights from Des Moines to Missouri

Our best United Airlines deals on Des Moines to Missouri flight tickets

United Airlines

Jun 2

DSM6:00 amDes Moines

6h 11m

1 stop

STL12:11 pmLambert-St Louis

Jun 3

STL6:00 amLambert-St Louis

4h 27m

1 stop

DSM10:27 amDes Moines

$349

United Airlines

Jun 2

DSM1:35 pmDes Moines

7h 08m

1 stop

STL8:43 pmLambert-St Louis

Jun 3

STL6:00 amLambert-St Louis

4h 27m

1 stop

DSM10:27 amDes Moines

$359

United Airlines

Apr 6

DSM3:21 pmDes Moines

5h 52m

1 stop

STL9:13 pmLambert-St Louis

Apr 8

STL7:45 amLambert-St Louis

4h 44m

1 stop

DSM12:29 pmDes Moines

$365

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 4/29

5:30 am-11:30 am

1 stop6h 00m

Lambert-St Louis

Wed 5/6

3:55 pm-9:15 pm

1 stop5h 20m

$279

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 4/29

5:30 am-9:30 am

1 stop4h 00m

Lambert-St Louis

Wed 5/6

3:10 pm-10:10 pm

2 stops7h 00m

$284

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 4/21

5:30 am-11:30 am

1 stop6h 00m

Lambert-St Louis

Sat 4/25

5:40 am-11:30 am

1 stop5h 50m

$288

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 4/29

5:30 am-3:15 pm

2 stops9h 45m

Lambert-St Louis

Wed 5/6

3:10 pm-10:10 pm

2 stops7h 00m

$289

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 4/21

5:30 am-3:15 pm

2 stops9h 45m

Lambert-St Louis

Sat 4/25

5:40 am-11:30 am

1 stop5h 50m

$293

Quickest round-trip

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 5/16

4:00 pm-9:29 pm

1 stop5h 29m

Lambert-St Louis

Sat 5/23

5:36 pm-9:03 pm

1 stop3h 27m

$297

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 5/16

11:57 am-6:00 pm

1 stop6h 03m

Lambert-St Louis

Sat 5/23

6:45 am-3:44 pm

2 stops8h 59m

$302

Des MoinesKansas City

DSM - MCI

DSMMCI

Des Moines

Sat 5/9

9:06 am-8:41 pm

1 stop11h 35m

Kansas City

Wed 5/13

8:49 am-8:16 pm

1 stop11h 27m

$614

Des MoinesKansas City

DSM - MCI

DSMMCI

Des Moines

Mon 6/8

7:06 pm-1:07 pm

1 stop18h 01m

Kansas City

Sat 6/13

9:05 am-12:12 am

1 stop15h 07m

$616

Des MoinesKansas City

DSM - MCI

DSMMCI

Des Moines

Sat 5/9

5:30 am-8:41 pm

1 stop15h 11m

Kansas City

Wed 5/13

6:00 am-4:15 pm

1 stop10h 15m

$623

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Missouri

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest day to depart on your flight to Missouri?

The cheapest day to depart from Des Moines to Missouri is on a Wednesday when prices can be found for as low as $350. Flights from Des Moines to Missouri on a Sunday will generally be more expensive and average around $418. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Missouri?

According to our data, the cheapest time of day to fly to Missouri is in the afternoon. momondo users have found flights departing from Des Moines to Missouri in the afternoon for as low as $364. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Missouri are more costly in the morning, with an average ticket price of $396. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Des Moines to Missouri flight route?

Fly from Des Moines to Lambert-St Louis for the best Des Moines - Missouri flight prices

What cabin class options are available on Des Moines to Missouri flights?

There is only 1 cabin class available to choose from on Des Moines to Missouri flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to Missouri flights?

No. A direct flight is the cheapest option for a flight between Des Moines to Missouri.

Cheap Des Moines to Missouri flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Missouri

Best Price Found	$462
Fastest flight time	4h 15m
Direct flights	None

The best flight deal from Des Moines to Missouri found on momondo in the last 72 hours is $462

The fastest flight from Des Moines to Missouri takes 4h 15m

There are no direct flights from Des Moines to Missouri. Popular non-direct route for this connection is Des Moines Airport - Lambert-St Louis Airport.

Search flight deals

Frequently asked questions about flying from Des Moines to Missouri

When did momondo last update prices for flights from Des Moines Airport to Missouri?
Prices for flights from Des Moines Airport to Missouri refresh daily.
How many operators does momondo search for flights from Des Moines Airport to Missouri?
There is 1 operator available for flights from Des Moines Airport to Missouri as of April 2026.
How old do you have to be to fly from Des Moines Airport to Missouri?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Missouri.
What documentation or ID do you need to fly to Missouri?
The necessary travel and health documents for your Missouri trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular plane model from Des Moines to Missouri?
Based on momondo bookings for this flight route, the most popular plane model on flight routes from Des Moines to Missouri is Airbus A320-100/200 (22.03% of total bookings). The next most popular plane models are Boeing 737 MAX 8 (18.64%), Airbus A319 (15.25%), and Airbus A320neo (5.93%).

Best airlines flying from Des Moines to Missouri

Compare and see reviews for airlines that fly from Des Moines to Missouri with momondo

Airline	Rating	Free Cancellation	Price
Southwest	PriceFrom $107	Free Cancellation	Rating 8.0 4,337 reviews	Search Southwest flights
United Airlines	PriceFrom $218	Free Cancellation	Rating 7.4 9,533 reviews	Search United Airlines flights
American Airlines	PriceFrom $218	Free Cancellation	Rating 7.1 11,549 reviews	Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Missouri?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Missouri for you.

Can I find flights from Des Moines to Missouri with flexible booking policies on momondo?

Yes. All flights to Missouri from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Missouri?

momondo helps you find the best flight between Des Moines and Missouri by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Missouri right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Missouri flights. All you need is a valid email address and we will do the rest; it is that quick and easy.