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Cheap flights from Des Moines to Missouri from $49

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Missouri departing on 9/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Des Moines to Missouri

Cheap round-trip flights

Southwest Logo
6:00 am - 7:05 amDSM-STL
1h 05mnonstop
Southwest Logo
9:40 pm - 10:50 pmSTL-DSM
1h 10mnonstop
$117Southwest
Find Deal
Thu, Sep 11 - Thu, Sep 18
Southwest Logo
5:35 am - 6:45 amDSM-STL
1h 10mnonstop
Southwest Logo
5:35 am - 12:10 pmSTL-DSM
6h 35m1 stop
$127Southwest
Find Deal
Thu, Oct 23 - Sat, Oct 25
Southwest Logo
8:35 am - 9:40 amDSM-STL
1h 05mnonstop
Southwest Logo
2:05 pm - 8:20 pmSTL-DSM
6h 15m2 stops
$132Southwest
Find Deal
Sat, Sep 13 - Sat, Sep 20
American Airlines Logo
4:25 pm - 9:53 pmDSM-STL
5h 28m1 stop
American Airlines Logo
8:42 am - 1:18 pmSTL-DSM
4h 36m1 stop
$159American Airlines
Find Deal
Tue, Sep 30 - Tue, Oct 7
Delta Logo
6:05 am - 1:22 pmDSM-STL
7h 17m1 stop
Delta Logo
6:00 am - 10:26 amSTL-DSM
4h 26m1 stop
$177Delta
Find Deal
Thu, Oct 23 - Sat, Oct 25
Delta Logo
10:55 am - 4:45 pmDSM-STL
5h 50m1 stop
Delta Logo
6:40 am - 5:16 pmSTL-DSM
10h 36m2 stops
$182Delta
Find Deal
Tue, Sep 30 - Tue, Oct 7
Frontier Logo
2:25 pm - 9:06 amDSM-STL
18h 41m1 stop
Frontier Logo
7:55 pm - 1:40 pmSTL-DSM
17h 45m1 stop
$205Frontier
Find Deal
Thu, Sep 18 - Sun, Sep 21
Frontier Logo
2:25 pm - 9:06 amDSM-STL
18h 41m1 stop
Frontier Logo
7:55 pm - 1:40 pmSTL-DSM
17h 45m1 stop
$223Frontier
Find Deal
Thu, Sep 11 - Thu, Sep 18
United Airlines Logo
11:35 am - 3:44 pmDSM-STL
4h 09m1 stop
United Airlines Logo
8:10 am - 2:20 pmSTL-DSM
6h 10m1 stop
$393United Airlines
Find Deal
Tue, Sep 2 - Sat, Sep 6
United Airlines Logo
1:10 pm - 11:44 pmDSM-STL
10h 34m2 stops
United Airlines Logo
5:15 am - 12:36 pmSTL-DSM
7h 21m1 stop
$416United Airlines
Find Deal
Fri, Sep 19 - Sun, Sep 21

Southwest flights from Des Moines to Missouri

Our best Southwest deals on Des Moines to Missouri flight tickets
Southwest
Sep 11
DSM6:00 amDes Moines
1h 05m
STL7:05 amLambert-St Louis
Sep 18
STL9:40 pmLambert-St Louis
1h 10m
DSM10:50 pmDes Moines
$117
Find similar
Southwest
Oct 23
DSM5:35 amDes Moines
1h 10m
STL6:45 amLambert-St Louis
Oct 25
STL5:35 amLambert-St Louis
6h 35m
1 stop
DSM12:10 pmDes Moines
$127
Find similar
Southwest
Sep 13
DSM8:35 amDes Moines
1h 05m
STL9:40 amLambert-St Louis
Sep 20
STL2:05 pmLambert-St Louis
6h 15m
2 stops
DSM8:20 pmDes Moines
$132
Find similar

American Airlines flights from Des Moines to Missouri

Our best American Airlines deals on Des Moines to Missouri flight tickets
American Airlines
Sep 30
DSM4:25 pmDes Moines
5h 28m
1 stop
STL9:53 pmLambert-St Louis
Oct 7
STL8:42 amLambert-St Louis
4h 36m
1 stop
DSM1:18 pmDes Moines
$159
Find similar
American Airlines
Aug 20
DSM3:49 pmDes Moines
4h 33m
1 stop
STL8:22 pmLambert-St Louis
Aug 21
STL8:50 amLambert-St Louis
3h 49m
1 stop
DSM12:39 pmDes Moines
$509
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momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 17, 2025.
Use the filters below to find and compare flights from Des Moines to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 9/11

6:00 am-7:05 am

Nonstop1h 05m

Lambert-St Louis

Thu 9/18

9:40 pm-10:50 pm

Nonstop1h 10m

$117

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 10/23

5:35 am-6:45 am

Nonstop1h 10m

Lambert-St Louis

Sat 10/25

5:35 am-12:10 pm

1 stop6h 35m

$127

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 9/13

8:35 am-9:40 am

Nonstop1h 05m

Lambert-St Louis

Sat 9/20

2:05 pm-8:20 pm

2 stops6h 15m

$132

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 9/30

4:25 pm-9:53 pm

1 stop5h 28m

Lambert-St Louis

Tue 10/7

8:42 am-1:18 pm

1 stop4h 36m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 10/23

6:05 am-1:22 pm

1 stop7h 17m

Lambert-St Louis

Sat 10/25

6:00 am-10:26 am

1 stop4h 26m

$177

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 9/30

10:55 am-4:45 pm

1 stop5h 50m

Lambert-St Louis

Tue 10/7

6:40 am-5:16 pm

2 stops10h 36m

$182

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 9/18

2:25 pm-9:06 am

1 stop18h 41m

Lambert-St Louis

Sun 9/21

7:55 pm-1:40 pm

1 stop17h 45m

$205

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 9/11

2:25 pm-9:06 am

1 stop18h 41m

Lambert-St Louis

Thu 9/18

7:55 pm-1:40 pm

1 stop17h 45m

$223

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 9/2

11:35 am-3:44 pm

1 stop4h 09m

Lambert-St Louis

Sat 9/6

8:10 am-2:20 pm

1 stop6h 10m

$393

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 9/19

1:10 pm-11:44 pm

2 stops10h 34m

Lambert-St Louis

Sun 9/21

5:15 am-12:36 pm

1 stop7h 21m

$416

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Missouri from

How to get the cheapest flight ticket from Des Moines to Missouri

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Missouri?

In general, September is the cheapest month to fly from Des Moines to Missouri. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $151. If you aren’t able to travel to Missouri during the month of September, then flying in August is also cheap. Prices for this month can be found on momondo for an average of $249.

What is the cheapest day to depart on your flight to Missouri?

The cheapest day to depart from Des Moines to Missouri is on a Tuesday when prices can be found for as low as $378. Flights from Des Moines to Missouri on a Saturday will generally be more expensive and average around $433. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Missouri?

According to our data, the cheapest time of day to fly to Missouri is in the afternoon. momondo users have found flights departing from Des Moines to Missouri in the afternoon for as low as $398. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Missouri are more costly in the morning, with an average ticket price of $411. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Des Moines to Missouri flight route?

Fly from Des Moines to Lambert-St Louis for the best Des Moines - Missouri flight prices

What cabin class options are available on Des Moines to Missouri flights?

There are 1 cabin classes available to choose from on Des Moines to Missouri flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to Missouri flights?

You could potentially save up to 26% on your flight if you consider stops on a Des Moines to Missouri flight.

Cheap Des Moines to Missouri flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Missouri

Best Price Found

$49

Fastest flight time

1h 05m

Direct flights

Mon, Wed, Fri and Sat

Airports in Missouri

2 airports
The best one-way flight to Missouri from Des Moines in the past 72 hours is $49. The best round-trip flight deal from Des Moines to Missouri found on momondo in the last 72 hours is $117.
The fastest flight from Des Moines to Missouri takes 1h 05m
Direct flights go from Des Moines to Missouri on Monday, Wednesday, Friday and Saturday. The only airline offering direct flights is Southwest.
There are 2 airports near Missouri: Kansas City (MCI), Lambert-St Louis (STL)
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  • When did momondo last update prices for flights from Des Moines Airport to Missouri?

    Prices for flights from Des Moines Airport to Missouri refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Missouri?

  • How old do you have to be to fly from Des Moines Airport to Missouri?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Missouri.

  • What documentation or ID do you need to fly to Missouri?

    The necessary travel and health documents for your Missouri trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Des Moines to Missouri?

Best airlines flying from Des Moines to Missouri

Compare and see reviews for airlines that fly from Des Moines to Missouri with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $97Free CancellationRating
8.0
4,246 reviews
Search Southwest flights
American AirlinesPriceFrom $218Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $218Free CancellationRating
7.4
8,919 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Missouri?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Missouri for you.

Can I find flights from Des Moines to Missouri with flexible booking policies on momondo?

Yes. All flights to Missouri from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Missouri?

momondo helps you find the best flight between Des Moines and Missouri by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Missouri right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Missouri flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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