What is the cheapest airline that flies from Des Moines to Missouri?

Southwest and United Airlines are the most popular carriers operating from Des Moines to Missouri

When did momondo last update prices for flights from Des Moines Airport to Missouri?

Prices for flights from Des Moines Airport to Missouri refresh daily.

How many operators does momondo search for flights from Des Moines Airport to Missouri?

There are 2 operators available for flights from Des Moines Airport to Missouri as of September 2026.

How old do you have to be to fly from Des Moines Airport to Missouri?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Missouri.

What documentation or ID do you need to fly to Missouri?

The necessary travel and health documents for your Missouri trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$171 Cheap Flights from Des Moines to Missouri in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Missouri

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

7:31 pm - 12:19 amDSM Des Moines-STL Lambert-St Louis

4h 48m1 stop Chicago O'Hare Intl

5:00 am - 8:56 amSTL Lambert-St Louis-DSM Des Moines

3h 56m1 stop Chicago O'Hare Intl

$271American Airlines

Wed, Oct 21 - Thu, Oct 22

3:11 pm - 7:41 pmDSM Des Moines-STL Lambert-St Louis

4h 30m1 stop Chicago O'Hare Intl

1:08 pm - 7:16 pmSTL Lambert-St Louis-DSM Des Moines

6h 08m1 stop Chicago O'Hare Intl

$271United Airlines

Tue, Oct 20 - Tue, Oct 27

6:35 pm - 11:15 pmDSM Des Moines-STL Lambert-St Louis

4h 40m1 stop Denver Intl

2:20 pm - 10:00 pmSTL Lambert-St Louis-DSM Des Moines

7h 40m2 stops Atlanta Hartsfield-Jackson Chicago Midway

$276Southwest

Tue, Oct 20 - Tue, Oct 27

2:01 pm - 8:57 pmDSM Des Moines-STL Lambert-St Louis

6h 56m1 stop Chicago O'Hare Intl

5:00 am - 8:56 amSTL Lambert-St Louis-DSM Des Moines

3h 56m1 stop Chicago O'Hare Intl

$281American Airlines

Wed, Oct 21 - Thu, Oct 22

7:31 pm - 12:19 amDSM Des Moines-STL Lambert-St Louis

4h 48m1 stop Chicago O'Hare Intl

5:00 am - 8:56 amSTL Lambert-St Louis-DSM Des Moines

3h 56m1 stop Chicago O'Hare Intl

$289American Airlines

Thu, Oct 22 - Fri, Oct 23

5:35 am - 3:00 pmDSM Des Moines-STL Lambert-St Louis

9h 25m2 stops Chicago Midway Atlanta Hartsfield-Jackson

5:25 am - 11:10 amSTL Lambert-St Louis-DSM Des Moines

5h 45m1 stop Chicago Midway

$294Southwest

Wed, Oct 21 - Thu, Oct 22

8:25 pm - 6:57 pmDSM Des Moines-STL Lambert-St Louis

22h 32m1 stop Denver Intl

6:35 pm - 1:59 pmSTL Lambert-St Louis-DSM Des Moines

43h 24m2 stops Atlanta Hartsfield-Jackson Philadelphia

$299Multiple Airlines

Fri, Oct 16 - Fri, Oct 23

5:35 am - 3:00 pmDSM Des Moines-STL Lambert-St Louis

9h 25m2 stops Chicago Midway Atlanta Hartsfield-Jackson

2:20 pm - 10:00 pmSTL Lambert-St Louis-DSM Des Moines

7h 40m2 stops Atlanta Hartsfield-Jackson Chicago Midway

$299Southwest

Tue, Oct 20 - Tue, Oct 27

7:31 pm - 12:19 amDSM Des Moines-STL Lambert-St Louis

4h 48m1 stop Chicago O'Hare Intl

7:29 am - 1:30 pmSTL Lambert-St Louis-DSM Des Moines

6h 01m1 stop Chicago O'Hare Intl

$299American Airlines

Thu, Oct 22 - Fri, Oct 23

6:05 am - 12:10 pmDSM Des Moines-STL Lambert-St Louis

6h 05m1 stop Chicago O'Hare Intl

1:08 pm - 5:28 pmSTL Lambert-St Louis-DSM Des Moines

4h 20m1 stop Chicago O'Hare Intl

$315United Airlines

Thu, Nov 26 - Sat, Nov 28

Cheap last minute flights

Enter your travel dates to find the best prices.

7:58 pm - 12:27 amDSM Des Moines-STL Lambert-St Louis

4h 29m1 stop Chicago O'Hare Intl

7:27 am - 1:59 pmSTL Lambert-St Louis-DSM Des Moines

6h 32m1 stop Chicago O'Hare Intl

$519American Airlines

Sat, Sep 26 - Sun, Sep 27

5:57 pm - 12:27 amDSM Des Moines-STL Lambert-St Louis

6h 30m1 stop Chicago O'Hare Intl

7:27 am - 1:59 pmSTL Lambert-St Louis-DSM Des Moines

6h 32m1 stop Chicago O'Hare Intl

$519American Airlines

Fri, Sep 25 - Sat, Sep 26

7:15 am - 1:05 pmDSM Des Moines-STL Lambert-St Louis

5h 50m1 stop Denver Intl

8:35 am - 1:55 pmSTL Lambert-St Louis-DSM Des Moines

5h 20m1 stop Denver Intl

$519Southwest

Tue, Sep 29 - Wed, Sep 30

3:11 pm - 7:01 pmDSM Des Moines-STL Lambert-St Louis

3h 50m1 stop Chicago O'Hare Intl

6:00 am - 10:31 amSTL Lambert-St Louis-DSM Des Moines

4h 31m1 stop Chicago O'Hare Intl

$519United Airlines

Fri, Sep 25 - Mon, Sep 28

10:30 am - 4:48 pmDSM Des Moines-STL Lambert-St Louis

6h 18m1 stop Chicago O'Hare Intl

7:21 am - 1:59 pmSTL Lambert-St Louis-DSM Des Moines

6h 38m1 stop Chicago O'Hare Intl

$519American Airlines

Tue, Sep 29 - Wed, Sep 30

6:10 am - 11:20 amDSM Des Moines-STL Lambert-St Louis

5h 10m1 stop Chicago Midway

3:05 pm - 10:00 pmSTL Lambert-St Louis-DSM Des Moines

6h 55m2 stops Atlanta Hartsfield-Jackson Chicago Midway

$524Southwest

Tue, Sep 29 - Wed, Sep 30

6:10 am - 1:55 pmDSM Des Moines-STL Lambert-St Louis

7h 45m2 stops Chicago Midway Nashville Intl

10:15 am - 10:00 pmSTL Lambert-St Louis-DSM Des Moines

11h 45m2 stops Nashville Intl Chicago Midway

$529Southwest

Tue, Sep 29 - Wed, Sep 30

3:50 pm - 7:05 pmDSM Des Moines-STL Lambert-St Louis

3h 15m1 stop Chicago Midway

8:30 am - 7:30 pmSTL Lambert-St Louis-DSM Des Moines

11h 00m2 stops Atlanta Hartsfield-Jackson Chicago Midway

$530Southwest

Fri, Sep 25 - Sat, Sep 26

10:57 am - 8:35 pmDSM Des Moines-STL Lambert-St Louis

9h 38m2 stops Minneapolis St Paul Detroit Metropolitan Wayne County

6:15 am - 10:17 amSTL Lambert-St Louis-DSM Des Moines

4h 02m1 stop Minneapolis St Paul

$584Delta

Sat, Sep 26 - Sun, Sep 27

10:57 am - 8:35 pmDSM Des Moines-STL Lambert-St Louis

9h 38m2 stops Minneapolis St Paul Detroit Metropolitan Wayne County

6:40 am - 4:48 pmSTL Lambert-St Louis-DSM Des Moines

10h 08m2 stops Detroit Metropolitan Wayne County Minneapolis St Paul

$980Delta

Sat, Sep 26 - Sun, Sep 27

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American Airlines flights from Des Moines to Missouri

Our best American Airlines deals on Des Moines to Missouri flight tickets

American Airlines

Oct 21

DSM2:01 pmDes Moines

6h 56m

1 stop

STL8:57 pmLambert-St Louis

Oct 22

STL5:00 amLambert-St Louis

3h 56m

1 stop

DSM8:56 amDes Moines

$281

American Airlines

Oct 22

DSM7:31 pmDes Moines

4h 48m

1 stop

STL12:19 amLambert-St Louis

Oct 23

STL5:00 amLambert-St Louis

3h 56m

1 stop

DSM8:56 amDes Moines

$289

American Airlines

Sep 26

DSM7:58 pmDes Moines

4h 29m

1 stop

STL12:27 amLambert-St Louis

Sep 27

STL7:27 amLambert-St Louis

6h 32m

1 stop

DSM1:59 pmDes Moines

$519

Southwest flights from Des Moines to Missouri

Our best Southwest deals on Des Moines to Missouri flight tickets

Southwest

Oct 20

DSM6:35 pmDes Moines

4h 40m

1 stop

STL11:15 pmLambert-St Louis

Oct 27

STL2:20 pmLambert-St Louis

7h 40m

2 stops

DSM10:00 pmDes Moines

$276

Southwest

Oct 21

DSM5:35 amDes Moines

9h 25m

2 stops

STL3:00 pmLambert-St Louis

Oct 22

STL5:25 amLambert-St Louis

5h 45m

1 stop

DSM11:10 amDes Moines

$294

Southwest

Oct 16

DSM7:10 pmDes Moines

4h 40m

1 stop

STL11:50 pmLambert-St Louis

Oct 23

STL6:10 pmLambert-St Louis

5h 05m

1 stop

DSM11:15 pmDes Moines

$307

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Quickest round-trip

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Wed 10/21

7:31 pm-12:19 am

1 stop4h 48m

Lambert-St Louis

Thu 10/22

5:00 am-8:56 am

1 stop3h 56m

$271

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Tue 10/20

3:11 pm-7:41 pm

1 stop4h 30m

Lambert-St Louis

Tue 10/27

1:08 pm-7:16 pm

1 stop6h 08m

$271

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Tue 10/20

6:35 pm-11:15 pm

1 stop4h 40m

Lambert-St Louis

Tue 10/27

2:20 pm-10:00 pm

2 stops7h 40m

$276

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Wed 10/21

2:01 pm-8:57 pm

1 stop6h 56m

Lambert-St Louis

Thu 10/22

5:00 am-8:56 am

1 stop3h 56m

$281

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Thu 10/22

7:31 pm-12:19 am

1 stop4h 48m

Lambert-St Louis

Fri 10/23

5:00 am-8:56 am

1 stop3h 56m

$289

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Wed 10/21

5:35 am-3:00 pm

2 stops9h 25m

Lambert-St Louis

Thu 10/22

5:25 am-11:10 am

1 stop5h 45m

$294

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Fri 10/16

8:25 pm-6:57 pm

1 stop22h 32m

Lambert-St Louis

Fri 10/23

6:35 pm-1:59 pm

2 stops43h 24m

$299

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Tue 10/20

5:35 am-3:00 pm

2 stops9h 25m

Lambert-St Louis

Tue 10/27

2:20 pm-10:00 pm

2 stops7h 40m

$299

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Thu 10/22

7:31 pm-12:19 am

1 stop4h 48m

Lambert-St Louis

Fri 10/23

7:29 am-1:30 pm

1 stop6h 01m

$299

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Thu 11/26

6:05 am-12:10 pm

1 stop6h 05m

Lambert-St Louis

Sat 11/28

1:08 pm-5:28 pm

1 stop4h 20m

$315

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Missouri

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Missouri?

In general, November is the cheapest month to fly from Des Moines to Missouri. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $0. If you aren’t able to travel to Missouri during the month of November, then flying in July is also cheap. Prices for this month can be found on momondo for an average of $0.

What is the cheapest day to depart on your flight to Missouri?

The cheapest day to depart from Des Moines to Missouri is on a Wednesday when prices can be found for as low as $364. Flights from Des Moines to Missouri on a Sunday will generally be more expensive and average around $462. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Missouri?

According to our data, the cheapest time of day to fly to Missouri is in the afternoon. momondo users have found flights departing from Des Moines to Missouri in the afternoon for as low as $367. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Missouri are more costly in the morning, with an average ticket price of $404. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Des Moines to Missouri flight route?

Fly from Des Moines to Lambert-St Louis for the best Des Moines - Missouri flight prices

What cabin class options are available on Des Moines to Missouri flights?

There is only 1 cabin class available to choose from on Des Moines to Missouri flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to Missouri flights?

No. A direct flight is the cheapest option for a flight between Des Moines to Missouri.

Cheap Des Moines to Missouri flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Missouri

Best Price Found	$171
Fastest flight time	4h 13m
Direct flights	None

The best one-way flight to Missouri from Des Moines in the past 72 hours is $171. The best round-trip flight deal from Des Moines to Missouri found on momondo in the last 72 hours is $271.

The fastest flight from Des Moines to Missouri takes 4h 13m

There are no direct flights from Des Moines to Missouri. Popular non-direct route for this connection is Des Moines Airport - Lambert-St Louis Airport.

Search flight deals

Frequently asked questions about flying from Des Moines to Missouri

When did momondo last update prices for flights from Des Moines Airport to Missouri?
Prices for flights from Des Moines Airport to Missouri refresh daily.
How many operators does momondo search for flights from Des Moines Airport to Missouri?
There are 2 operators available for flights from Des Moines Airport to Missouri as of September 2026.
How old do you have to be to fly from Des Moines Airport to Missouri?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Missouri.
What documentation or ID do you need to fly to Missouri?
The necessary travel and health documents for your Missouri trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular plane model from Des Moines to Missouri?
Based on momondo bookings for this flight route, the most popular plane model on flight routes from Des Moines to Missouri is Airbus A319 (22.22% of total bookings). The next most popular plane models are Airbus A320-100/200 (20.37%), Airbus A320neo (12.96%), and Boeing 737-800 (9.26%).

Best airlines flying from Des Moines to Missouri

Compare and see reviews for airlines that fly from Des Moines to Missouri with momondo

Airline	Rating	Free Cancellation	Price
Southwest	PriceFrom $107	Free Cancellation	Rating 8.0 4,199 reviews		Search Southwest flights
American Airlines	PriceFrom $158	Free Cancellation	Rating 7.0 12,074 reviews		Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Missouri?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Missouri for you.

Can I find flights from Des Moines to Missouri with flexible booking policies on momondo?

Yes. All flights to Missouri from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Missouri?

momondo helps you find the best flight between Des Moines and Missouri by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Missouri right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Missouri flights. All you need is a valid email address and we will do the rest; it is that quick and easy.