What is the cheapest airline that flies from Des Moines to Missouri?

United Airlines and Southwest are the most popular carriers operating from Des Moines to Missouri

When did momondo last update prices for flights from Des Moines Airport to Missouri?

Prices for flights from Des Moines Airport to Missouri refresh daily.

How many operators does momondo search for flights from Des Moines Airport to Missouri?

There are 2 operators available for flights from Des Moines Airport to Missouri as of July 2026.

How old do you have to be to fly from Des Moines Airport to Missouri?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Missouri.

What documentation or ID do you need to fly to Missouri?

The necessary travel and health documents for your Missouri trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$105 Cheap Flights from Des Moines to Missouri in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Missouri

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

7:00 am - 12:55 pm

DSM

STL

5h 55m

1 stop

8:06 pm - 12:35 am

STL

DSM

4h 29m

1 stop

$209American Airlines

Sat, Aug 22 - Sat, Aug 29

2:44 pm - 8:44 pm

DSM

STL

6h 00m

1 stop

11:01 am - 5:27 pm

STL

DSM

6h 26m

1 stop

$209American Airlines

Sat, Sep 12 - Sat, Sep 19

6:10 am - 9:35 am

DSM

STL

3h 25m

1 stop

6:30 am - 11:50 am

STL

DSM

5h 20m

1 stop

$209Southwest

Tue, Sep 8 - Tue, Sep 15

5:25 am - 10:05 am

DSM

STL

4h 40m

1 stop

7:15 pm - 11:00 pm

STL

DSM

3h 45m

1 stop

$209Southwest

Mon, Nov 2 - Thu, Nov 5

3:20 pm - 10:00 pm

DSM

STL

6h 40m

1 stop

8:30 am - 2:16 pm

STL

DSM

5h 46m

1 stop

$209United Airlines

Tue, Aug 25 - Tue, Sep 1

3:22 pm - 10:00 pm

DSM

STL

6h 38m

1 stop

8:00 am - 2:20 pm

STL

DSM

6h 20m

1 stop

$209United Airlines

Tue, Sep 8 - Tue, Sep 15

7:00 am - 10:23 am

DSM

STL

3h 23m

1 stop

6:15 am - 10:17 am

STL

DSM

4h 02m

1 stop

$209Delta

Thu, Sep 10 - Thu, Sep 17

5:40 am - 9:15 am

DSM

STL

3h 35m

1 stop

8:25 am - 11:30 am

STL

DSM

3h 05m

1 stop

$209Southwest

Thu, Sep 17 - Sat, Sep 19

7:49 pm - 12:14 am

DSM

STL

4h 25m

1 stop

6:00 am - 10:00 am

STL

DSM

4h 00m

1 stop

$253American Airlines

Fri, Sep 4 - Mon, Sep 7

7:49 pm - 12:14 am

DSM

STL

4h 25m

1 stop

5:00 am - 9:56 am

STL

DSM

4h 56m

1 stop

$282American Airlines

Thu, Aug 20 - Sun, Aug 30

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United Airlines flights from Des Moines to Missouri

Our best United Airlines deals on Des Moines to Missouri flight tickets

United Airlines

Sep 8

DSM3:22 pmDes Moines

6h 38m

1 stop

STL10:00 pmLambert-St Louis

Sep 15

STL8:00 amLambert-St Louis

6h 20m

1 stop

DSM2:20 pmDes Moines

$209

United Airlines

Aug 10

DSM6:50 pmDes Moines

4h 39m

1 stop

STL11:29 pmLambert-St Louis

Aug 13

STL6:00 amLambert-St Louis

4h 26m

1 stop

DSM10:26 amDes Moines

$425

United Airlines

Aug 10

DSM6:50 pmDes Moines

4h 39m

1 stop

STL11:29 pmLambert-St Louis

Aug 13

STL6:00 amLambert-St Louis

4h 26m

1 stop

DSM10:26 amDes Moines

$477

Southwest flights from Des Moines to Missouri

Our best Southwest deals on Des Moines to Missouri flight tickets

Southwest

Sep 8

DSM2:40 pmDes Moines

3h 15m

1 stop

STL5:55 pmLambert-St Louis

Sep 15

STL3:05 pmLambert-St Louis

6h 55m

2 stops

DSM10:00 pmDes Moines

$214

Southwest

Sep 8

DSM2:40 pmDes Moines

7h 35m

2 stops

STL10:15 pmLambert-St Louis

Sep 15

STL2:50 pmLambert-St Louis

6h 15m

2 stops

DSM9:05 pmDes Moines

$219

Southwest

Sep 17

DSM5:40 amDes Moines

3h 35m

1 stop

STL9:15 amLambert-St Louis

Sep 19

STL8:30 amLambert-St Louis

11h 00m

2 stops

DSM7:30 pmDes Moines

$220

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 8/22

7:00 am-12:55 pm

1 stop5h 55m

Lambert-St Louis

Sat 8/29

8:06 pm-12:35 am

1 stop4h 29m

$209

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 9/12

2:44 pm-8:44 pm

1 stop6h 00m

Lambert-St Louis

Sat 9/19

11:01 am-5:27 pm

1 stop6h 26m

$209

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 9/8

6:10 am-9:35 am

1 stop3h 25m

Lambert-St Louis

Tue 9/15

6:30 am-11:50 am

1 stop5h 20m

$209

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 11/2

5:25 am-10:05 am

1 stop4h 40m

Lambert-St Louis

Thu 11/5

7:15 pm-11:00 pm

1 stop3h 45m

$209

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 8/25

3:20 pm-10:00 pm

1 stop6h 40m

Lambert-St Louis

Tue 9/1

8:30 am-2:16 pm

1 stop5h 46m

$209

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 9/8

3:22 pm-10:00 pm

1 stop6h 38m

Lambert-St Louis

Tue 9/15

8:00 am-2:20 pm

1 stop6h 20m

$209

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 9/10

7:00 am-10:23 am

1 stop3h 23m

Lambert-St Louis

Thu 9/17

6:15 am-10:17 am

1 stop4h 02m

$209

Quickest round-trip

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 9/17

5:40 am-9:15 am

1 stop3h 35m

Lambert-St Louis

Sat 9/19

8:25 am-11:30 am

1 stop3h 05m

$209

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 9/4

7:49 pm-12:14 am

1 stop4h 25m

Lambert-St Louis

Mon 9/7

6:00 am-10:00 am

1 stop4h 00m

$253

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 8/20

7:49 pm-12:14 am

1 stop4h 25m

Lambert-St Louis

Sun 8/30

5:00 am-9:56 am

1 stop4h 56m

$282

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Missouri

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Missouri?

In general, November is the cheapest month to fly from Des Moines to Missouri. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $0. If you aren’t able to travel to Missouri during the month of November, then flying in August is also cheap. Prices for this month can be found on momondo for an average of $0.

What is the cheapest day to depart on your flight to Missouri?

The cheapest day to depart from Des Moines to Missouri is on a Tuesday when prices can be found for as low as $355. Flights from Des Moines to Missouri on a Friday will generally be more expensive and average around $409. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Missouri?

According to our data, the cheapest time of day to fly to Missouri is in the afternoon. momondo users have found flights departing from Des Moines to Missouri in the afternoon for as low as $360. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Missouri are more costly in the morning, with an average ticket price of $398. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Des Moines to Missouri flight route?

Fly from Des Moines to Lambert-St Louis for the best Des Moines - Missouri flight prices

What cabin class options are available on Des Moines to Missouri flights?

There is only 1 cabin class available to choose from on Des Moines to Missouri flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to Missouri flights?

No. A direct flight is the cheapest option for a flight between Des Moines to Missouri.

Cheap Des Moines to Missouri flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Missouri

Best Price Found	$462
Fastest flight time	4h 01m
Direct flights	None

The best flight deal from Des Moines to Missouri found on momondo in the last 72 hours is $462

The fastest flight from Des Moines to Missouri takes 4h 01m

There are no direct flights from Des Moines to Missouri. Popular non-direct route for this connection is Des Moines Airport - Lambert-St Louis Airport.

Search flight deals

Frequently asked questions about flying from Des Moines to Missouri

When did momondo last update prices for flights from Des Moines Airport to Missouri?
Prices for flights from Des Moines Airport to Missouri refresh daily.
How many operators does momondo search for flights from Des Moines Airport to Missouri?
There are 2 operators available for flights from Des Moines Airport to Missouri as of July 2026.
How old do you have to be to fly from Des Moines Airport to Missouri?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Missouri.
What documentation or ID do you need to fly to Missouri?
The necessary travel and health documents for your Missouri trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular plane model from Des Moines to Missouri?
Based on momondo bookings for this flight route, the most popular plane model on flight routes from Des Moines to Missouri is Airbus A320-100/200 (24.56% of total bookings). The next most popular plane models are Airbus A319 (21.05%), Airbus A320neo (12.28%), and Boeing 737-800 (8.77%).

Best airlines flying from Des Moines to Missouri

Compare and see reviews for airlines that fly from Des Moines to Missouri with momondo

Airline	Rating	Free Cancellation	Price
Southwest	PriceFrom $107	Free Cancellation	Rating 8.0 4,227 reviews		Search Southwest flights
American Airlines	PriceFrom $158	Free Cancellation	Rating 7.1 11,839 reviews		Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Missouri?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Missouri for you.

Can I find flights from Des Moines to Missouri with flexible booking policies on momondo?

Yes. All flights to Missouri from Des Moines on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Des Moines to Missouri?

momondo helps you find the best flight between Des Moines and Missouri by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Missouri right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to Missouri flights. All you need is a valid email address and we will do the rest; it is that quick and easy.