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Cheap flights from Des Moines to Greenville from $186

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Greenville departing on 5/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
7:28 am - 3:14 pm
DSM
-
GSP
6h 46m
1 stop
Delta Logo
5:42 am - 11:05 am
GSP
-
DSM
6h 23m
1 stop
$263Delta
Sal, Nis 21 - Çar, Nis 22
American Airlines Logo
5:01 pm - 11:03 pm
DSM
-
GSP
5h 02m
1 stop
American Airlines Logo
5:20 am - 11:30 am
GSP
-
DSM
7h 10m
2 stops
$268American Airlines
Sal, Nis 21 - Çar, Nis 22
American Airlines Logo
6:00 am - 3:03 pm
DSM
-
GSP
8h 03m
2 stops
American Airlines Logo
5:20 am - 11:30 am
GSP
-
DSM
7h 10m
2 stops
$273American Airlines
Sal, Nis 21 - Çar, Nis 22
Southwest Logo
5:30 am - 8:00 pm
DSM
-
GSP
13h 30m
2 stops
Southwest Logo
5:05 pm - 10:10 pm
GSP
-
DSM
6h 05m
2 stops
$279Southwest
Sal, Nis 28 - Sal, May 5
American Airlines Logo
5:01 pm - 11:03 pm
DSM
-
GSP
5h 02m
1 stop
American Airlines Logo
6:30 am - 1:20 pm
GSP
-
DSM
7h 50m
1 stop
$290American Airlines
Sal, Nis 21 - Cmt, Nis 25
American Airlines Logo
1:38 pm - 9:13 pm
DSM
-
GSP
6h 35m
1 stop
American Airlines Logo
7:02 am - 1:46 pm
GSP
-
DSM
7h 44m
2 stops
$295American Airlines
Sal, Nis 21 - Cmt, Nis 25
American Airlines Logo
6:00 am - 3:03 pm
DSM
-
GSP
8h 03m
2 stops
American Airlines Logo
7:02 am - 1:46 pm
GSP
-
DSM
7h 44m
2 stops
$300American Airlines
Sal, Nis 21 - Cmt, Nis 25
Southwest Logo
5:25 am - 5:50 pm
DSM
-
GSP
11h 25m
2 stops
Southwest Logo
5:05 pm - 10:10 pm
GSP
-
DSM
6h 05m
2 stops
$307Southwest
Pzt, Nis 27 - Sal, May 5
American Airlines Logo
2:16 pm - 7:46 pm
DSM
-
GSP
4h 30m
1 stop
American Airlines Logo
5:12 pm - 11:59 pm
GSP
-
DSM
7h 47m
1 stop
$317American Airlines
Pzt, May 4 - Per, May 7
American Airlines Logo
5:01 pm - 11:02 pm
DSM
-
GSP
5h 01m
1 stop
American Airlines Logo
5:20 am - 11:30 am
GSP
-
DSM
7h 10m
2 stops
$322American Airlines
Cmt, May 16 - Çar, May 20

Delta flights from Des Moines to Greenville

Our best Delta deals on Des Moines to Greenville flight tickets
Delta
Apr 21
DSM7:28 amDes Moines
6h 46m
1 stop
GSP3:14 pmGreenville
Apr 22
GSP5:42 amGreenville
6h 23m
1 stop
DSM11:05 amDes Moines
$263
Delta
May 19
DSM6:41 pmDes Moines
4h 02m
1 stop
GSP11:43 pmGreenville
Jun 11
GSP8:52 amGreenville
6h 09m
1 stop
DSM2:01 pmDes Moines
$335
Delta
Apr 13
DSM7:28 amDes Moines
6h 46m
1 stop
GSP3:14 pmGreenville
Apr 21
GSP11:35 amGreenville
8h 53m
1 stop
DSM7:28 pmDes Moines
$375

American Airlines flights from Des Moines to Greenville

Our best American Airlines deals on Des Moines to Greenville flight tickets
American Airlines
Apr 21
DSM5:01 pmDes Moines
5h 02m
1 stop
GSP11:03 pmGreenville
Apr 22
GSP5:20 amGreenville
7h 10m
2 stops
DSM11:30 amDes Moines
$268
American Airlines
Apr 21
DSM6:00 amDes Moines
8h 03m
2 stops
GSP3:03 pmGreenville
Apr 22
GSP5:20 amGreenville
7h 10m
2 stops
DSM11:30 amDes Moines
$273
American Airlines
Apr 21
DSM5:01 pmDes Moines
5h 02m
1 stop
GSP11:03 pmGreenville
Apr 25
GSP6:30 amGreenville
7h 50m
1 stop
DSM1:20 pmDes Moines
$290

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated Mart 28, 2026.
Use the filters below to find and compare flights from Des Moines to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sal 4/21

7:28 am-3:14 pm

1 stop6h 46m

Greenville

Çar 4/22

5:42 am-11:05 am

1 stop6h 23m

$263

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sal 4/21

5:01 pm-11:03 pm

1 stop5h 02m

Greenville

Çar 4/22

5:20 am-11:30 am

2 stops7h 10m

$268

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sal 4/21

6:00 am-3:03 pm

2 stops8h 03m

Greenville

Çar 4/22

5:20 am-11:30 am

2 stops7h 10m

$273

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sal 4/28

5:30 am-8:00 pm

2 stops13h 30m

Greenville

Sal 5/5

5:05 pm-10:10 pm

2 stops6h 05m

$279

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sal 4/21

5:01 pm-11:03 pm

1 stop5h 02m

Greenville

Cmt 4/25

6:30 am-1:20 pm

1 stop7h 50m

$290

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sal 4/21

1:38 pm-9:13 pm

1 stop6h 35m

Greenville

Cmt 4/25

7:02 am-1:46 pm

2 stops7h 44m

$295

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sal 4/21

6:00 am-3:03 pm

2 stops8h 03m

Greenville

Cmt 4/25

7:02 am-1:46 pm

2 stops7h 44m

$300

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Pzt 4/27

5:25 am-5:50 pm

2 stops11h 25m

Greenville

Sal 5/5

5:05 pm-10:10 pm

2 stops6h 05m

$307

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Pzt 5/4

2:16 pm-7:46 pm

1 stop4h 30m

Greenville

Per 5/7

5:12 pm-11:59 pm

1 stop7h 47m

$317
Quickest round-trip

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Cmt 5/16

5:01 pm-11:02 pm

1 stop5h 01m

Greenville

Çar 5/20

5:20 am-11:30 am

2 stops7h 10m

$322

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
1
2

See travel insights to Greenville from

How to get the cheapest flight ticket from Des Moines to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Greenville?

What is the cheapest month to fly to Greenville?

The month of October is another great option to travel to Greenville, with average flight prices from Des Moines averaging around $295.

Can stopping save me money on Des Moines to Greenville flights?

You could potentially save up to 43% on your flight if you consider stops on a Des Moines to Greenville flight.

When to book flights from Des Moines to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Greenville (DSM to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Greenville

Fastest flight time

4h 02m

Direct flights

None
The fastest flight from Des Moines to Greenville takes 4h 02m
There are no direct flights from Des Moines to Greenville. There are no popular flight routes from Des Moines to Greenville.
Search flight deals

  • How far is Des Moines to Greenville by plane?

    Des Moines and Greenville are 765.4 mi apart from one another. A reasonable flight in good conditions will take 4h 02m.

  • When did momondo last update prices for flights from Des Moines Airport to Greenville Airport?

    Prices for flights from Des Moines Airport to Greenville Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Des Moines Airport to Greenville Airport?

  • How old do you have to be to fly from Des Moines Airport to Greenville Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Greenville?

Best airlines flying from Des Moines to Greenville

Compare and see reviews for airlines that fly from Des Moines to Greenville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $243Free CancellationRating
7.9
8,356 reviews
Search Delta flights
American AirlinesPriceFrom $296Free CancellationRating
7.1
11,520 reviews
Search American Airlines flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Greer
Seneca
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Greenville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Greenville from Des Moines.

Can I find flights from Des Moines to Greenville with flexible booking policies on momondo?

All flight searches from Des Moines to Greenville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Greenville?

Once you have performed a search for Des Moines to Greenville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Greenville right now. Can momondo alert me if prices change?

Price alerts on flights to Greenville from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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