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Cheap flights from Des Moines to Greenville from $139

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Greenville departing on 8/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
9:23 am - 7:30 am
DSM
-
GSP
21h 07m
1 stop
Allegiant Air Logo
3:30 pm - 11:14 pm
GSP
-
DSM
32h 44m
2 stops
$322Allegiant Air
Thu, Jul 30 - Thu, Aug 6
United Airlines Logo
3:22 pm - 9:18 pm
DSM
-
GSP
4h 56m
1 stop
United Airlines Logo
4:19 pm - 11:33 pm
GSP
-
DSM
8h 14m
1 stop
$336United Airlines
Wed, Sep 9 - Mon, Sep 14
United Airlines Logo
8:00 am - 7:45 pm
DSM
-
GSP
10h 45m
2 stops
United Airlines Logo
4:19 pm - 11:33 pm
GSP
-
DSM
8h 14m
1 stop
$341United Airlines
Wed, Sep 9 - Mon, Sep 14
American Airlines Logo
5:10 pm - 10:50 pm
DSM
-
GSP
4h 40m
1 stop
American Airlines Logo
1:37 pm - 6:41 pm
GSP
-
DSM
6h 04m
1 stop
$355American Airlines
Tue, Aug 18 - Tue, Aug 25
United Airlines Logo
8:00 am - 7:05 pm
DSM
-
GSP
10h 05m
2 stops
United Airlines Logo
5:43 pm - 9:23 pm
GSP
-
DSM
4h 40m
1 stop
$360United Airlines
Tue, Aug 18 - Tue, Aug 25
Delta Logo
4:11 pm - 10:30 pm
DSM
-
GSP
5h 19m
1 stop
Delta Logo
5:20 pm - 10:37 pm
GSP
-
DSM
6h 17m
1 stop
$362Delta
Sat, Aug 29 - Sat, Sep 5
Southwest Logo
7:15 am - 4:45 pm
DSM
-
GSP
8h 30m
2 stops
Southwest Logo
7:00 am - 1:55 pm
GSP
-
DSM
7h 55m
2 stops
$366Southwest
Tue, Aug 18 - Tue, Aug 25
American Airlines Logo
1:08 pm - 8:29 pm
DSM
-
GSP
6h 21m
1 stop
American Airlines Logo
7:39 am - 1:25 pm
GSP
-
DSM
6h 46m
1 stop
$372American Airlines
Thu, Sep 3 - Sun, Sep 6
American Airlines Logo
6:12 am - 2:04 pm
DSM
-
GSP
6h 52m
1 stop
American Airlines Logo
6:45 am - 1:25 pm
GSP
-
DSM
7h 40m
1 stop
$391American Airlines
Sun, Aug 2 - Sat, Aug 8
Southwest Logo
5:10 am - 1:05 pm
DSM
-
GSP
6h 55m
2 stops
Southwest Logo
11:05 am - 8:45 pm
GSP
-
DSM
10h 40m
2 stops
$392Southwest
Sun, Aug 2 - Sat, Aug 8

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American Airlines flights from Des Moines to Greenville

Our best American Airlines deals on Des Moines to Greenville flight tickets
American Airlines
Aug 18
DSM5:10 pmDes Moines
4h 40m
1 stop
GSP10:50 pmGreenville
Aug 25
GSP1:37 pmGreenville
6h 04m
1 stop
DSM6:41 pmDes Moines
$355
American Airlines
Sep 3
DSM1:08 pmDes Moines
6h 21m
1 stop
GSP8:29 pmGreenville
Sep 6
GSP7:39 amGreenville
6h 46m
1 stop
DSM1:25 pmDes Moines
$372
American Airlines
Aug 2
DSM6:12 amDes Moines
6h 52m
1 stop
GSP2:04 pmGreenville
Aug 8
GSP6:45 amGreenville
7h 40m
1 stop
DSM1:25 pmDes Moines
$391

Southwest flights from Des Moines to Greenville

Our best Southwest deals on Des Moines to Greenville flight tickets
Southwest
Aug 18
DSM7:15 amDes Moines
8h 30m
2 stops
GSP4:45 pmGreenville
Aug 25
GSP7:00 amGreenville
7h 55m
2 stops
DSM1:55 pmDes Moines
$366
Southwest
Aug 2
DSM5:10 amDes Moines
6h 55m
2 stops
GSP1:05 pmGreenville
Aug 8
GSP11:05 amGreenville
10h 40m
2 stops
DSM8:45 pmDes Moines
$392
Southwest
Aug 4
DSM6:10 amDes Moines
9h 35m
2 stops
GSP4:45 pmGreenville
Aug 10
GSP1:05 pmGreenville
10h 05m
2 stops
DSM10:10 pmDes Moines
$423

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 6, 2026.
Use the filters below to find and compare flights from Des Moines to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 7/30

9:23 am-7:30 am

1 stop21h 07m

Greenville

Thu 8/6

3:30 pm-11:14 pm

2 stops32h 44m

$322

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Wed 9/9

3:22 pm-9:18 pm

1 stop4h 56m

Greenville

Mon 9/14

4:19 pm-11:33 pm

1 stop8h 14m

$336

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Wed 9/9

8:00 am-7:45 pm

2 stops10h 45m

Greenville

Mon 9/14

4:19 pm-11:33 pm

1 stop8h 14m

$341
Quickest round-trip

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Tue 8/18

5:10 pm-10:50 pm

1 stop4h 40m

Greenville

Tue 8/25

1:37 pm-6:41 pm

1 stop6h 04m

$355

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Tue 8/18

8:00 am-7:05 pm

2 stops10h 05m

Greenville

Tue 8/25

5:43 pm-9:23 pm

1 stop4h 40m

$360

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sat 8/29

4:11 pm-10:30 pm

1 stop5h 19m

Greenville

Sat 9/5

5:20 pm-10:37 pm

1 stop6h 17m

$362

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Tue 8/18

7:15 am-4:45 pm

2 stops8h 30m

Greenville

Tue 8/25

7:00 am-1:55 pm

2 stops7h 55m

$366

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 9/3

1:08 pm-8:29 pm

1 stop6h 21m

Greenville

Sun 9/6

7:39 am-1:25 pm

1 stop6h 46m

$372

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sun 8/2

6:12 am-2:04 pm

1 stop6h 52m

Greenville

Sat 8/8

6:45 am-1:25 pm

1 stop7h 40m

$391

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sun 8/2

5:10 am-1:05 pm

2 stops6h 55m

Greenville

Sat 8/8

11:05 am-8:45 pm

2 stops10h 40m

$392

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Des Moines to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Greenville?

What is the cheapest month to fly to Greenville?

The month of October is another great option to travel to Greenville, with average flight prices from Des Moines averaging around $304.

Can stopping save me money on Des Moines to Greenville flights?

You could potentially save up to 32% on your flight if you consider stops on a Des Moines to Greenville flight.

When to book flights from Des Moines to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Greenville (DSM to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Greenville

Fastest flight time

4h 05m

Direct flights

None
The fastest flight from Des Moines to Greenville takes 4h 05m
There are no direct flights from Des Moines to Greenville. There are no popular flight routes from Des Moines to Greenville.
Search flight deals

Frequently asked questions about flying from Des Moines to Greenville

  • How far is Des Moines to Greenville by plane?

    Des Moines and Greenville are 765.4 mi apart from one another. A reasonable flight in good conditions will take 4h 05m.

  • When did momondo last update prices for flights from Des Moines Airport to Greenville Airport?

    Prices for flights from Des Moines Airport to Greenville Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Des Moines Airport to Greenville Airport?

  • How old do you have to be to fly from Des Moines Airport to Greenville Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Greenville?

Best airlines flying from Des Moines to Greenville

Compare and see reviews for airlines that fly from Des Moines to Greenville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $243Free CancellationRating
7.8
8,452 reviews
Search Delta flights
American AirlinesPriceFrom $304Free CancellationRating
7.1
11,782 reviews
Search American Airlines flights
United AirlinesPriceFrom $362Free CancellationRating
7.4
9,938 reviews
Search United Airlines flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Greer
Seneca
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Greenville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Greenville from Des Moines.

Can I find flights from Des Moines to Greenville with flexible booking policies on momondo?

All flight searches from Des Moines to Greenville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Greenville?

Once you have performed a search for Des Moines to Greenville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Greenville right now. Can momondo alert me if prices change?

Price alerts on flights to Greenville from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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