Cheap flights from Des Moines to Greenville from $155
This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Greenville departing on 9/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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American Airlines flights from Des Moines to Greenville
Our best American Airlines deals on Des Moines to Greenville flight tickets
Southwest flights from Des Moines to Greenville
Our best Southwest deals on Des Moines to Greenville flight tickets
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How to get the cheapest flight ticket from Des Moines to Greenville
Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip
What is the cheapest month to fly to Greenville?
The month of October is another great option to travel to Greenville, with average flight prices from Des Moines averaging around $323.
What is the cheapest day to depart on your flight to Greenville?
According to our data, Friday is the cheapest day to fly to Greenville from Des Moines. The lowest ticket price found for a Friday departure recently was $349. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Tuesday because tickets tend to average around $608. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.
What is the cheapest airline that flies from Des Moines to Greenville?
American Airlines and United Airlines are the most popular carriers operating from Des Moines to Greenville
What airlines fly to Greenville?
American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Greenville from Des Moines according to our data. American Airlines is the first choice among our users, with 79% of people opting to fly with this airline when traveling to Greenville. Keep in mind that there are 3 different airlines that fly to Greenville on a routine basis, so you have a few additional options to choose from.
When to book flights from Des Moines to Greenville
Cheap Des Moines to Greenville (DSM to GSP) flight deals and tips
Find info about flight duration, direct flights, and airports for your flight from Des Moines to Greenville
How far is Des Moines to Greenville by plane?
Des Moines and Greenville are 765.4 mi apart from one another. A reasonable flight in good conditions will take 4h 19m.
When did momondo last update prices for flights from Des Moines Airport to Greenville Airport?
Prices for flights from Des Moines Airport to Greenville Airport are refreshed on a daily basis.
How many operators does momondo search for flights from Des Moines Airport to Greenville Airport?
The number of operators available for flights from Des Moines Airport to Greenville Airport is 2 as of June 2025.
How old do you have to be to fly from Des Moines Airport to Greenville Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Greenville Airport.
What documentation or ID do you need to fly to Greenville Airport?
The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Des Moines to Greenville?
Based on momondo bookings for this flight route, the most popular airline on flight routes from Des Moines to Greenville is American Airlines (61% of total bookings). The next most popular airline is Delta (39%).
Best airlines flying from Des Moines to Greenville
Compare and see reviews for airlines that fly from Des Moines to Greenville with momondo
| Airline | Rating | Free Cancellation | Price | ||
|---|---|---|---|---|---|
| PriceFrom $286 | Free Cancellation | Rating 8.0 7,963 reviews | |||
| PriceFrom $296 | Free Cancellation | Rating 7.2 10,000 reviews |
Traveling to a place near Greenville?
Book flights to Greenville if you plan to visit one of these locationsWhy use momondo?
Why should I use momondo to find a flight deal from Des Moines to Greenville?
To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Greenville from Des Moines.
Can I find flights from Des Moines to Greenville with flexible booking policies on momondo?
All flight searches from Des Moines to Greenville on momondo can be filtered to show those which offer flexible booking policies.
How can momondo help me find flights from Des Moines to Greenville?
Once you have performed a search for Des Moines to Greenville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.
I’m not ready to book a flight from Des Moines to Greenville right now. Can momondo alert me if prices change?
Price alerts on flights to Greenville from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.