What is the cheapest airline that flies from Des Moines to Greenville?

Delta, American Airlines, and Southwest are the most popular carriers operating from Des Moines to Greenville

When did momondo last update prices for flights from Des Moines Airport to Greenville Airport?

Prices for flights from Des Moines Airport to Greenville Airport are refreshed on a daily basis.

How many operators does momondo search for flights from Des Moines Airport to Greenville Airport?

The number of operators available for flights from Des Moines Airport to Greenville Airport is 2 as of August 2025.

How old do you have to be to fly from Des Moines Airport to Greenville Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Greenville Airport.

What documentation or ID do you need to fly to Greenville Airport?

The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$119 Cheap Flights from Des Moines to Greenville (DSM-GSP) in 2025

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Find the cheapest flights from Des Moines to Greenville (DSM-GSP)

Round-trip

One-way

Last minute

Cheap round-trip flights

1:24 pm - 7:44 pmDSM-GSP

5h 20m1 stop

8:14 pm - 11:44 pmGSP-DSM

4h 30m1 stop

$267American Airlines

Find Deal

Thu, Nov 13 - Sun, Nov 16

12:45 pm - 10:14 pmDSM-GSP

8h 29m1 stop

6:00 am - 12:04 pmGSP-DSM

7h 04m1 stop

$278Delta

Find Deal

Wed, Nov 12 - Mon, Nov 17

3:50 pm - 10:00 pmDSM-GSP

5h 10m1 stop

8:37 pm - 12:15 amGSP-DSM

4h 38m1 stop

$298American Airlines

Find Deal

Wed, Sep 17 - Sun, Sep 21

12:45 pm - 10:14 pmDSM-GSP

8h 29m1 stop

6:45 am - 10:18 amGSP-DSM

4h 33m1 stop

$328Delta

Find Deal

Thu, Nov 20 - Sun, Nov 23

7:15 am - 2:38 pmDSM-GSP

6h 23m1 stop

5:30 am - 10:38 amGSP-DSM

6h 08m1 stop

$332Delta

Find Deal

Tue, Aug 19 - Tue, Aug 26

7:32 am - 4:48 pmDSM-GSP

8h 16m2 stops

7:21 pm - 10:58 pmGSP-DSM

4h 37m1 stop

$337American Airlines

Find Deal

Tue, Aug 19 - Tue, Aug 26

8:00 am - 9:35 pmDSM-GSP

12h 35m2 stops

8:00 am - 11:35 pmGSP-DSM

16h 35m2 stops

$375Southwest

Find Deal

Thu, Nov 13 - Sun, Nov 16

6:00 am - 3:03 pmDSM-GSP

8h 03m1 stop

6:02 am - 12:23 pmGSP-DSM

7h 21m2 stops

$432United Airlines

Find Deal

Mon, Aug 18 - Fri, Aug 22

8:25 am - 6:05 pmDSM-GSP

8h 40m2 stops

1:50 pm - 10:50 pmGSP-DSM

10h 00m2 stops

$437Southwest

Find Deal

Tue, Aug 19 - Thu, Aug 21

6:24 am - 6:57 pmDSM-GSP

11h 33m2 stops

2:51 pm - 2:10 pmGSP-DSM

24h 19m2 stops

$583United Airlines

Find Deal

Mon, Aug 18 - Fri, Aug 22

Delta flights from Des Moines to Greenville

Our best Delta deals on Des Moines to Greenville flight tickets

Delta

Nov 12

DSM12:45 pmDes Moines

8h 29m

1 stop

GSP10:14 pmGreenville

Nov 17

GSP6:00 amGreenville

7h 04m

1 stop

DSM12:04 pmDes Moines

$278

Find similar

Delta

Nov 20

DSM12:45 pmDes Moines

8h 29m

1 stop

GSP10:14 pmGreenville

Nov 23

GSP6:45 amGreenville

4h 33m

1 stop

DSM10:18 amDes Moines

$328

Find similar

Delta

Aug 19

DSM7:15 amDes Moines

6h 23m

1 stop

GSP2:38 pmGreenville

Aug 26

GSP5:30 amGreenville

6h 08m

1 stop

DSM10:38 amDes Moines

$332

Find similar

American Airlines flights from Des Moines to Greenville

Our best American Airlines deals on Des Moines to Greenville flight tickets

American Airlines

Nov 13

DSM1:24 pmDes Moines

5h 20m

1 stop

GSP7:44 pmGreenville

Nov 16

GSP8:14 pmGreenville

4h 30m

1 stop

DSM11:44 pmDes Moines

$267

Find similar

American Airlines

Sep 17

DSM3:50 pmDes Moines

5h 10m

1 stop

GSP10:00 pmGreenville

Sep 21

GSP8:37 pmGreenville

4h 38m

1 stop

DSM12:15 amDes Moines

$298

Find similar

American Airlines

Aug 19

DSM7:32 amDes Moines

8h 16m

2 stops

GSP4:48 pmGreenville

Aug 26

GSP7:21 pmGreenville

4h 37m

1 stop

DSM10:58 pmDes Moines

$337

Find similar

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 11/13

1:24 pm-7:44 pm

1 stop5h 20m

Greenville

Sun 11/16

8:14 pm-11:44 pm

1 stop4h 30m

$267

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Wed 11/12

12:45 pm-10:14 pm

1 stop8h 29m

Greenville

Mon 11/17

6:00 am-12:04 pm

1 stop7h 04m

$278

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Wed 9/17

3:50 pm-10:00 pm

1 stop5h 10m

Greenville

Sun 9/21

8:37 pm-12:15 am

1 stop4h 38m

$298

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 11/20

12:45 pm-10:14 pm

1 stop8h 29m

Greenville

Sun 11/23

6:45 am-10:18 am

1 stop4h 33m

$328

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Tue 8/19

7:15 am-2:38 pm

1 stop6h 23m

Greenville

Tue 8/26

5:30 am-10:38 am

1 stop6h 08m

$332

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Tue 8/19

7:32 am-4:48 pm

2 stops8h 16m

Greenville

Tue 8/26

7:21 pm-10:58 pm

1 stop4h 37m

$337

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 11/13

8:00 am-9:35 pm

2 stops12h 35m

Greenville

Sun 11/16

8:00 am-11:35 pm

2 stops16h 35m

$375

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Mon 8/18

6:00 am-3:03 pm

1 stop8h 03m

Greenville

Fri 8/22

6:02 am-12:23 pm

2 stops7h 21m

$432

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Tue 8/19

8:25 am-6:05 pm

2 stops8h 40m

Greenville

Thu 8/21

1:50 pm-10:50 pm

2 stops10h 00m

$437

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Mon 8/18

6:24 am-6:57 pm

2 stops11h 33m

Greenville

Fri 8/22

2:51 pm-2:10 pm

2 stops24h 19m

$583

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Greenville?

The month of January is another great option to travel to Greenville, with average flight prices from Des Moines averaging around $333.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Friday is the cheapest day to fly to Greenville from Des Moines. The lowest ticket price found for a Friday departure recently was $349. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Tuesday because tickets tend to average around $608. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the afternoon. Flights from Des Moines to Greenville during this time can be as low as $373. Flights to Greenville are more costly in the morning, with an average ticket price of $437. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

When to book flights from Des Moines to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Greenville according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Greenville (DSM to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Greenville

Best Price Found	$119
Fastest flight time	3h 59m
Direct flights	None
Airports in Greenville	1 airport

The best one-way flight to Greenville from Des Moines in the past 72 hours is $119. The best round-trip flight deal from Des Moines to Greenville found on momondo in the last 72 hours is $267.

The fastest flight from Des Moines to Greenville takes 3h 59m

There are no direct flights from Des Moines to Greenville. Popular non-direct route for this connection is Des Moines Airport - Greenville Airport.

There is 1 airport near Greenville: Greenville (GSP)

Search flight deals

How far is Des Moines to Greenville by plane?
Des Moines and Greenville are 765.4 mi apart from one another. A reasonable flight in good conditions will take 5h 10m.
When did momondo last update prices for flights from Des Moines Airport to Greenville Airport?
Prices for flights from Des Moines Airport to Greenville Airport are refreshed on a daily basis.
How many operators does momondo search for flights from Des Moines Airport to Greenville Airport?
The number of operators available for flights from Des Moines Airport to Greenville Airport is 2 as of August 2025.
How old do you have to be to fly from Des Moines Airport to Greenville Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Greenville Airport.
What documentation or ID do you need to fly to Greenville Airport?
The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Des Moines to Greenville?
Based on momondo bookings for this flight route, the most popular airline on flight routes from Des Moines to Greenville is American Airlines (60% of total bookings). The next most popular airline is Delta (40%).

Best airlines flying from Des Moines to Greenville

Compare and see reviews for airlines that fly from Des Moines to Greenville with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $243	Free Cancellation	Rating 8.0 7,987 reviews		Search Delta flights
American Airlines	PriceFrom $296	Free Cancellation	Rating 7.2 10,000 reviews		Search American Airlines flights

Anderson

Simpsonville

Greenwood

Seneca

Greer

Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Greenville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Greenville from Des Moines.

Can I find flights from Des Moines to Greenville with flexible booking policies on momondo?

All flight searches from Des Moines to Greenville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Greenville?

Once you have performed a search for Des Moines to Greenville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Greenville right now. Can momondo alert me if prices change?

Price alerts on flights to Greenville from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.