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Cheap flights from Des Moines to Greenville from $159

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
2:59 pm - 10:12 pmDSM  Des Moines-GSP Greenville
6h 13m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:05 am - 10:51 amGSP  Greenville-DSM Des Moines
4h 46m1 stop Atlanta Hartsfield-Jackson
$325Delta
Wed, Nov 18 - Mon, Nov 23
Delta Logo
4:07 pm - 10:51 pmDSM  Des Moines-GSP Greenville
5h 44m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:00 am - 10:42 amGSP  Greenville-DSM Des Moines
4h 42m1 stop Atlanta Hartsfield-Jackson
$325Delta
Sat, Oct 10 - Tue, Oct 13
American Airlines Logo
1:30 pm - 6:59 pmDSM  Des Moines-GSP Greenville
4h 29m1 stop Charlotte Douglas
American Airlines Logo
6:32 am - 12:04 pmGSP  Greenville-DSM Des Moines
6h 32m1 stop Charlotte Douglas
$325American Airlines
Wed, Sep 23 - Tue, Sep 29
American Airlines Logo
2:26 pm - 9:00 pmDSM  Des Moines-GSP Greenville
5h 34m1 stop Washington, D.C. Reagan-National
American Airlines Logo
5:25 pm - 11:07 pmGSP  Greenville-DSM Des Moines
6h 42m1 stop Dallas/Fort Worth
$325American Airlines
Mon, Oct 5 - Thu, Oct 8
United Airlines Logo
3:11 pm - 9:17 pmDSM  Des Moines-GSP Greenville
5h 06m1 stop Chicago O'Hare Intl
United Airlines Logo
5:46 pm - 11:35 pmGSP  Greenville-DSM Des Moines
6h 49m1 stop Chicago O'Hare Intl
$325United Airlines
Tue, Oct 13 - Tue, Oct 20
Delta Logo
11:27 am - 6:02 pmDSM  Des Moines-GSP Greenville
5h 35m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:00 am - 10:42 amGSP  Greenville-DSM Des Moines
4h 42m1 stop Atlanta Hartsfield-Jackson
$325Delta
Sat, Oct 10 - Tue, Oct 13
United Airlines Logo
3:11 pm - 9:17 pmDSM  Des Moines-GSP Greenville
5h 06m1 stop Chicago O'Hare Intl
United Airlines Logo
6:00 am - 2:15 pmGSP  Greenville-DSM Des Moines
9h 15m2 stops Newark Chicago O'Hare Intl
$330United Airlines
Mon, Sep 28 - Wed, Sep 30
United Airlines Logo
11:27 am - 11:13 pmDSM  Des Moines-GSP Greenville
10h 46m2 stops Chicago O'Hare Intl Newark
United Airlines Logo
5:46 pm - 9:23 pmGSP  Greenville-DSM Des Moines
4h 37m1 stop Chicago O'Hare Intl
$330United Airlines
Sat, Oct 10 - Tue, Oct 13
Southwest Logo
4:30 pm - 10:50 pmDSM  Des Moines-GSP Greenville
5h 20m2 stops Chicago Midway Nashville Intl
Southwest Logo
6:25 am - 11:10 amGSP  Greenville-DSM Des Moines
5h 45m2 stops Nashville Intl Chicago Midway
$335Southwest
Mon, Oct 5 - Thu, Oct 8
Southwest Logo
5:50 am - 7:35 pmDSM  Des Moines-GSP Greenville
12h 45m2 stops Chicago Midway Baltimore/Washington
Southwest Logo
1:25 pm - 10:00 pmGSP  Greenville-DSM Des Moines
9h 35m2 stops Baltimore/Washington Chicago Midway
$341Southwest
Sat, Oct 10 - Tue, Oct 13

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American Airlines flights from Des Moines to Greenville

Our best American Airlines deals on Des Moines to Greenville flight tickets
American Airlines
Sep 23
DSM1:30 pmDes Moines
4h 29m
1 stop
GSP6:59 pmGreenville
Sep 29
GSP6:32 amGreenville
6h 32m
1 stop
DSM12:04 pmDes Moines
$325
American Airlines
Oct 10
DSM9:26 amDes Moines
7h 42m
1 stop
GSP6:08 pmGreenville
Oct 13
GSP4:55 pmGreenville
6h 50m
1 stop
DSM10:45 pmDes Moines
$358
American Airlines
Nov 18
DSM11:09 amDes Moines
4h 41m
1 stop
GSP4:50 pmGreenville
Nov 22
GSP3:28 pmGreenville
8h 17m
1 stop
DSM10:45 pmDes Moines
$371

United Airlines flights from Des Moines to Greenville

Our best United Airlines deals on Des Moines to Greenville flight tickets
United Airlines
Sep 28
DSM3:11 pmDes Moines
5h 06m
1 stop
GSP9:17 pmGreenville
Sep 30
GSP6:00 amGreenville
9h 15m
2 stops
DSM2:15 pmDes Moines
$330
United Airlines
Oct 13
DSM3:11 pmDes Moines
5h 06m
1 stop
GSP9:17 pmGreenville
Oct 20
GSP6:00 amGreenville
9h 15m
2 stops
DSM2:15 pmDes Moines
$332
United Airlines
Oct 10
DSM11:27 amDes Moines
4h 38m
1 stop
GSP5:05 pmGreenville
Oct 13
GSP6:00 amGreenville
9h 15m
2 stops
DSM2:15 pmDes Moines
$363

momondo Fare Finder

 
Use the filters below to find and compare flights from Des Moines to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesGreenville

DSM Des Moines - GSP Greenville

DSMGSP

Des Moines

Wed 11/18

2:59 pm-10:12 pm

1 stop6h 13m

Greenville

Mon 11/23

7:05 am-10:51 am

1 stop4h 46m

$325

Des MoinesGreenville

DSM Des Moines - GSP Greenville

DSMGSP

Des Moines

Sat 10/10

4:07 pm-10:51 pm

1 stop5h 44m

Greenville

Tue 10/13

7:00 am-10:42 am

1 stop4h 42m

$325

Des MoinesGreenville

DSM Des Moines - GSP Greenville

DSMGSP

Des Moines

Wed 9/23

1:30 pm-6:59 pm

1 stop4h 29m

Greenville

Tue 9/29

6:32 am-12:04 pm

1 stop6h 32m

$325

Des MoinesGreenville

DSM Des Moines - GSP Greenville

DSMGSP

Des Moines

Mon 10/5

2:26 pm-9:00 pm

1 stop5h 34m

Greenville

Thu 10/8

5:25 pm-11:07 pm

1 stop6h 42m

$325

Des MoinesGreenville

DSM Des Moines - GSP Greenville

DSMGSP

Des Moines

Tue 10/13

3:11 pm-9:17 pm

1 stop5h 06m

Greenville

Tue 10/20

5:46 pm-11:35 pm

1 stop6h 49m

$325
Quickest round-trip

Des MoinesGreenville

DSM Des Moines - GSP Greenville

DSMGSP

Des Moines

Sat 10/10

11:27 am-6:02 pm

1 stop5h 35m

Greenville

Tue 10/13

7:00 am-10:42 am

1 stop4h 42m

$325

Des MoinesGreenville

DSM Des Moines - GSP Greenville

DSMGSP

Des Moines

Mon 9/28

3:11 pm-9:17 pm

1 stop5h 06m

Greenville

Wed 9/30

6:00 am-2:15 pm

2 stops9h 15m

$330

Des MoinesGreenville

DSM Des Moines - GSP Greenville

DSMGSP

Des Moines

Sat 10/10

11:27 am-11:13 pm

2 stops10h 46m

Greenville

Tue 10/13

5:46 pm-9:23 pm

1 stop4h 37m

$330

Des MoinesGreenville

DSM Des Moines - GSP Greenville

DSMGSP

Des Moines

Mon 10/5

4:30 pm-10:50 pm

2 stops5h 20m

Greenville

Thu 10/8

6:25 am-11:10 am

2 stops5h 45m

$335

Des MoinesGreenville

DSM Des Moines - GSP Greenville

DSMGSP

Des Moines

Sat 10/10

5:50 am-7:35 pm

2 stops12h 45m

Greenville

Tue 10/13

1:25 pm-10:00 pm

2 stops9h 35m

$341

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Des Moines to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Greenville?

The month of January is another great option to travel to Greenville, with average flight prices from Des Moines averaging around $386.

Can stopping save me money on Des Moines to Greenville flights?

You could potentially save up to 55% on your flight if you consider stops on a Des Moines to Greenville flight.

When to book flights from Des Moines to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Greenville (DSM to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Greenville

Best Price Found

$159

Fastest flight time

4h 29m

Direct flights

None
The best one-way flight to Greenville from Des Moines in the past 72 hours is $159. The best round-trip flight deal from Des Moines to Greenville found on momondo in the last 72 hours is $325.
The fastest flight from Des Moines to Greenville takes 4h 29m
There are no direct flights from Des Moines to Greenville. There are no popular flight routes from Des Moines to Greenville.
Search flight deals

Frequently asked questions about flying from Des Moines to Greenville

  • How far is Des Moines to Greenville by plane?

    Des Moines and Greenville are 765.4 mi apart from one another. A reasonable flight in good conditions will take 4h 29m.

  • When did momondo last update prices for flights from Des Moines Airport to Greenville Airport?

    Prices for flights from Des Moines Airport to Greenville Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Des Moines Airport to Greenville Airport?

  • How old do you have to be to fly from Des Moines Airport to Greenville Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Greenville?

Best airlines flying from Des Moines to Greenville

Compare and see reviews for airlines that fly from Des Moines to Greenville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $316Free CancellationRating
7.8
8,573 reviews
Search Delta flights
American AirlinesPriceFrom $333Free CancellationRating
7.1
12,044 reviews
Search American Airlines flights
United AirlinesPriceFrom $362Free CancellationRating
7.4
10,171 reviews
Search United Airlines flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Greer
Duncan
Seneca

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Greenville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Greenville from Des Moines.

Can I find flights from Des Moines to Greenville with flexible booking policies on momondo?

All flight searches from Des Moines to Greenville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Greenville?

Once you have performed a search for Des Moines to Greenville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Greenville right now. Can momondo alert me if prices change?

Price alerts on flights to Greenville from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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