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Cheap flights from Des Moines to Greenville from $185

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Des Moines to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
8:07 am - 1:15 pmDSM  Des Moines-GSP Greenville
4h 08m1 stop Charlotte Douglas
American Airlines Logo
5:21 pm - 11:03 pmGSP  Greenville-DSM Des Moines
6h 42m1 stop Charlotte Douglas
$325American Airlines
Sat, Jan 23 - Sat, Jan 23
American Airlines Logo
11:09 am - 7:09 pmDSM  Des Moines-GSP Greenville
7h 00m1 stop Charlotte Douglas
American Airlines Logo
6:47 pm - 12:33 amGSP  Greenville-DSM Des Moines
6h 46m1 stop Chicago O'Hare Intl
$325American Airlines
Sat, Dec 5 - Mon, Dec 7
American Airlines Logo
11:06 am - 7:21 pmDSM  Des Moines-GSP Greenville
7h 15m1 stop Chicago O'Hare Intl
American Airlines Logo
3:55 pm - 10:29 pmGSP  Greenville-DSM Des Moines
7h 34m1 stop Chicago O'Hare Intl
$325American Airlines
Sat, Jan 16 - Sat, Jan 23
United Airlines Logo
12:52 pm - 11:34 pmDSM  Des Moines-GSP Greenville
9h 42m2 stops Chicago O'Hare Intl Newark
United Airlines Logo
6:30 am - 12:17 pmGSP  Greenville-DSM Des Moines
6h 47m1 stop Chicago O'Hare Intl
$330United Airlines
Thu, Jan 21 - Sat, Jan 23
United Airlines Logo
11:27 am - 11:40 pmDSM  Des Moines-GSP Greenville
11h 13m2 stops Chicago O'Hare Intl Newark
United Airlines Logo
5:34 pm - 9:25 pmGSP  Greenville-DSM Des Moines
4h 51m1 stop Chicago O'Hare Intl
$330United Airlines
Sat, Dec 5 - Mon, Dec 7
United Airlines Logo
9:25 am - 7:07 pmDSM  Des Moines-GSP Greenville
8h 42m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl
United Airlines Logo
6:30 am - 10:41 amGSP  Greenville-DSM Des Moines
5h 11m1 stop Chicago O'Hare Intl
$330United Airlines
Sat, Jan 16 - Sat, Jan 23
Delta Logo
6:53 pm - 11:47 pmDSM  Des Moines-GSP Greenville
3h 54m1 stop Atlanta Hartsfield-Jackson
Delta Logo
10:57 am - 4:49 pmGSP  Greenville-DSM Des Moines
6h 52m1 stop Detroit Metropolitan Wayne County
$359Delta
Thu, Dec 10 - Sun, Dec 13
Delta Logo
5:30 am - 10:48 amDSM  Des Moines-GSP Greenville
4h 18m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:15 am - 12:41 pmGSP  Greenville-DSM Des Moines
7h 26m1 stop Atlanta Hartsfield-Jackson
$379Delta
Thu, Dec 24 - Thu, Dec 31
Southwest Logo
5:20 am - 12:15 pmDSM  Des Moines-GSP Greenville
5h 55m2 stops Chicago Midway Nashville Intl
Southwest Logo
2:50 pm - 10:05 pmGSP  Greenville-DSM Des Moines
8h 15m2 stops Baltimore/Washington Chicago Midway
$379Southwest
Sat, Dec 5 - Mon, Dec 7
Southwest Logo
6:00 am - 6:10 pmDSM  Des Moines-GSP Greenville
11h 10m2 stops Chicago Midway Nashville Intl
Southwest Logo
2:50 pm - 10:05 pmGSP  Greenville-DSM Des Moines
8h 15m2 stops Baltimore/Washington Chicago Midway
$397Southwest
Fri, Dec 4 - Mon, Dec 7

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American Airlines flights from Des Moines to Greenville

Our best American Airlines deals on Des Moines to Greenville flight tickets
American Airlines
Jan 16
DSM11:06 amDes Moines
7h 15m
1 stop
GSP7:21 pmGreenville
Jan 23
GSP3:55 pmGreenville
7h 34m
1 stop
DSM10:29 pmDes Moines
$325
American Airlines
Dec 10
DSM3:31 pmDes Moines
5h 21m
1 stop
GSP9:52 pmGreenville
Dec 13
GSP7:00 amGreenville
4h 58m
1 stop
DSM10:58 amDes Moines
$412
American Airlines
Dec 10
DSM7:14 amDes Moines
7h 56m
1 stop
GSP4:10 pmGreenville
Dec 13
GSP4:01 pmGreenville
7h 59m
2 stops
DSM11:00 pmDes Moines
$431

United Airlines flights from Des Moines to Greenville

Our best United Airlines deals on Des Moines to Greenville flight tickets
United Airlines
Jan 16
DSM9:25 amDes Moines
8h 42m
2 stops
GSP7:07 pmGreenville
Jan 23
GSP6:30 amGreenville
5h 11m
1 stop
DSM10:41 amDes Moines
$330
United Airlines
Jan 16
DSM9:25 amDes Moines
8h 42m
2 stops
GSP7:07 pmGreenville
Jan 23
GSP12:35 pmGreenville
9h 53m
2 stops
DSM9:28 pmDes Moines
$335
United Airlines
Jan 21
DSM6:15 amDes Moines
7h 07m
2 stops
GSP2:22 pmGreenville
Jan 23
GSP12:35 pmGreenville
9h 53m
2 stops
DSM9:28 pmDes Moines
$370

momondo Fare Finder

 
Use the filters below to find and compare flights from Des Moines to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesGreenville

DSM Des Moines - GSP Greenville

DSMGSP

Des Moines

Sat 1/23

8:07 am-1:15 pm

1 stop4h 08m

Greenville

Sat 1/23

5:21 pm-11:03 pm

1 stop6h 42m

$325

Des MoinesGreenville

DSM Des Moines - GSP Greenville

DSMGSP

Des Moines

Sat 12/5

11:09 am-7:09 pm

1 stop7h 00m

Greenville

Mon 12/7

6:47 pm-12:33 am

1 stop6h 46m

$325

Des MoinesGreenville

DSM Des Moines - GSP Greenville

DSMGSP

Des Moines

Sat 1/16

11:06 am-7:21 pm

1 stop7h 15m

Greenville

Sat 1/23

3:55 pm-10:29 pm

1 stop7h 34m

$325

Des MoinesGreenville

DSM Des Moines - GSP Greenville

DSMGSP

Des Moines

Thu 1/21

12:52 pm-11:34 pm

2 stops9h 42m

Greenville

Sat 1/23

6:30 am-12:17 pm

1 stop6h 47m

$330

Des MoinesGreenville

DSM Des Moines - GSP Greenville

DSMGSP

Des Moines

Sat 12/5

11:27 am-11:40 pm

2 stops11h 13m

Greenville

Mon 12/7

5:34 pm-9:25 pm

1 stop4h 51m

$330

Des MoinesGreenville

DSM Des Moines - GSP Greenville

DSMGSP

Des Moines

Sat 1/16

9:25 am-7:07 pm

2 stops8h 42m

Greenville

Sat 1/23

6:30 am-10:41 am

1 stop5h 11m

$330
Quickest round-trip

Des MoinesGreenville

DSM Des Moines - GSP Greenville

DSMGSP

Des Moines

Thu 12/10

6:53 pm-11:47 pm

1 stop3h 54m

Greenville

Sun 12/13

10:57 am-4:49 pm

1 stop6h 52m

$359

Des MoinesGreenville

DSM Des Moines - GSP Greenville

DSMGSP

Des Moines

Thu 12/24

5:30 am-10:48 am

1 stop4h 18m

Greenville

Thu 12/31

6:15 am-12:41 pm

1 stop7h 26m

$379

Des MoinesGreenville

DSM Des Moines - GSP Greenville

DSMGSP

Des Moines

Sat 12/5

5:20 am-12:15 pm

2 stops5h 55m

Greenville

Mon 12/7

2:50 pm-10:05 pm

2 stops8h 15m

$379

Des MoinesGreenville

DSM Des Moines - GSP Greenville

DSMGSP

Des Moines

Fri 12/4

6:00 am-6:10 pm

2 stops11h 10m

Greenville

Mon 12/7

2:50 pm-10:05 pm

2 stops8h 15m

$397

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Des Moines to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Greenville?

The month of September is another great option to travel to Greenville, with average flight prices from Des Moines averaging around $380.

Can stopping save me money on Des Moines to Greenville flights?

You could potentially save up to 64% on your flight if you consider stops on a Des Moines to Greenville flight.

When to book flights from Des Moines to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Greenville (DSM to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Greenville

Best Price Found

$185

Fastest flight time

3h 54m

Direct flights

None
The best one-way flight to Greenville from Des Moines in the past 72 hours is $185. The best round-trip flight deal from Des Moines to Greenville found on momondo in the last 72 hours is $325.
The fastest flight from Des Moines to Greenville takes 3h 54m
There are no direct flights from Des Moines to Greenville. There are no popular flight routes from Des Moines to Greenville.
Search flight deals

Frequently asked questions about flying from Des Moines to Greenville

  • How far is Des Moines to Greenville by plane?

    Des Moines and Greenville are 765.4 mi apart from one another. A reasonable flight in good conditions will take 3h 54m.

  • When did momondo last update prices for flights from Des Moines Airport to Greenville Airport?

    Prices for flights from Des Moines Airport to Greenville Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Des Moines Airport to Greenville Airport?

  • How old do you have to be to fly from Des Moines Airport to Greenville Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Greenville?

Best airlines flying from Des Moines to Greenville

Compare and see reviews for airlines that fly from Des Moines to Greenville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $316Free CancellationRating
7.8
8,701 reviews
Search Delta flights
American AirlinesPriceFrom $344Free CancellationRating
7.0
12,233 reviews
Search American Airlines flights
United AirlinesPriceFrom $362Free CancellationRating
7.3
10,470 reviews
Search United Airlines flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Greenwood
Simpsonville
Greer
Duncan
Seneca

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Greenville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Greenville from Des Moines.

Can I find flights from Des Moines to Greenville with flexible booking policies on momondo?

All flight searches from Des Moines to Greenville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Greenville?

Once you have performed a search for Des Moines to Greenville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Greenville right now. Can momondo alert me if prices change?

Price alerts on flights to Greenville from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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