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Cheap flights from Des Moines to Greenville from $354

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Greenville departing on 6/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:37 pm - 11:54 pm
DSM
-
GSP
4h 17m
1 stop
Delta Logo
5:16 pm - 10:29 pm
GSP
-
DSM
6h 13m
1 stop
$355Delta
Wed, Jul 8 - Tue, Jul 21
American Airlines Logo
6:00 am - 2:02 pm
DSM
-
GSP
7h 02m
1 stop
American Airlines Logo
5:19 pm - 10:49 pm
GSP
-
DSM
6h 30m
1 stop
$375American Airlines
Mon, Aug 10 - Mon, Aug 17
Southwest Logo
5:40 am - 6:20 pm
DSM
-
GSP
11h 40m
2 stops
Southwest Logo
8:40 am - 9:15 pm
GSP
-
DSM
13h 35m
2 stops
$385Southwest
Mon, Aug 10 - Mon, Aug 17
Delta Logo
5:45 am - 10:58 am
DSM
-
GSP
4h 13m
1 stop
Delta Logo
5:45 am - 10:14 am
GSP
-
DSM
5h 29m
1 stop
$407Delta
Thu, Sep 3 - Sun, Sep 6
American Airlines Logo
1:35 pm - 9:17 pm
DSM
-
GSP
6h 42m
1 stop
American Airlines Logo
7:05 pm - 10:49 pm
GSP
-
DSM
4h 44m
1 stop
$411American Airlines
Sun, Aug 9 - Mon, Aug 17
American Airlines Logo
6:02 am - 2:07 pm
DSM
-
GSP
7h 05m
2 stops
American Airlines Logo
8:00 am - 12:34 pm
GSP
-
DSM
5h 34m
1 stop
$413American Airlines
Sat, Jul 4 - Sat, Jul 11
American Airlines Logo
1:33 pm - 7:51 pm
DSM
-
GSP
5h 18m
1 stop
American Airlines Logo
7:14 pm - 11:50 pm
GSP
-
DSM
5h 36m
1 stop
$417American Airlines
Fri, Jun 26 - Mon, Jun 29
Southwest Logo
5:10 am - 3:50 pm
DSM
-
GSP
9h 40m
2 stops
Southwest Logo
12:50 pm - 10:50 pm
GSP
-
DSM
11h 00m
2 stops
$423Southwest
Sat, Jul 4 - Sat, Jul 11
Allegiant Air Logo
5:30 pm - 7:35 am
DSM
-
GSP
37h 05m
2 stops
Allegiant Air Logo
3:10 pm - 10:15 pm
GSP
-
DSM
8h 05m
1 stop
$426Allegiant Air
Fri, Jul 3 - Fri, Jul 10
American Airlines Logo
6:02 am - 2:18 pm
DSM
-
GSP
7h 16m
1 stop
American Airlines Logo
5:25 pm - 11:58 pm
GSP
-
DSM
7h 33m
1 stop
$427American Airlines
Sat, Jun 13 - Sat, Jun 20

United Airlines flights from Des Moines to Greenville

Our best United Airlines deals on Des Moines to Greenville flight tickets
United Airlines
Sep 1
DSM5:45 amDes Moines
8h 30m
1 stop
GSP3:15 pmGreenville
Sep 2
GSP6:10 pmGreenville
5h 18m
1 stop
DSM10:28 pmDes Moines
$435
United Airlines
Jul 8
DSM11:23 amDes Moines
11h 11m
2 stops
GSP11:34 pmGreenville
Jul 21
GSP5:10 pmGreenville
6h 25m
1 stop
DSM10:35 pmDes Moines
$440
United Airlines
Sep 1
DSM5:45 amDes Moines
10h 19m
2 stops
GSP5:04 pmGreenville
Sep 2
GSP5:50 amGreenville
11h 29m
2 stops
DSM4:19 pmDes Moines
$445

American Airlines flights from Des Moines to Greenville

Our best American Airlines deals on Des Moines to Greenville flight tickets
American Airlines
Aug 10
DSM6:00 amDes Moines
7h 02m
1 stop
GSP2:02 pmGreenville
Aug 17
GSP5:19 pmGreenville
6h 30m
1 stop
DSM10:49 pmDes Moines
$375
American Airlines
Aug 9
DSM1:35 pmDes Moines
6h 42m
1 stop
GSP9:17 pmGreenville
Aug 17
GSP7:05 pmGreenville
4h 44m
1 stop
DSM10:49 pmDes Moines
$411
American Airlines
Jul 4
DSM6:02 amDes Moines
7h 05m
2 stops
GSP2:07 pmGreenville
Jul 11
GSP8:00 amGreenville
5h 34m
1 stop
DSM12:34 pmDes Moines
$413

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 24, 2026.
Use the filters below to find and compare flights from Des Moines to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Wed 7/8

6:37 pm-11:54 pm

1 stop4h 17m

Greenville

Tue 7/21

5:16 pm-10:29 pm

1 stop6h 13m

$355

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Mon 8/10

6:00 am-2:02 pm

1 stop7h 02m

Greenville

Mon 8/17

5:19 pm-10:49 pm

1 stop6h 30m

$375

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Mon 8/10

5:40 am-6:20 pm

2 stops11h 40m

Greenville

Mon 8/17

8:40 am-9:15 pm

2 stops13h 35m

$385
Quickest round-trip

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 9/3

5:45 am-10:58 am

1 stop4h 13m

Greenville

Sun 9/6

5:45 am-10:14 am

1 stop5h 29m

$407

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sun 8/9

1:35 pm-9:17 pm

1 stop6h 42m

Greenville

Mon 8/17

7:05 pm-10:49 pm

1 stop4h 44m

$411

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sat 7/4

6:02 am-2:07 pm

2 stops7h 05m

Greenville

Sat 7/11

8:00 am-12:34 pm

1 stop5h 34m

$413

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Fri 6/26

1:33 pm-7:51 pm

1 stop5h 18m

Greenville

Mon 6/29

7:14 pm-11:50 pm

1 stop5h 36m

$417

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sat 7/4

5:10 am-3:50 pm

2 stops9h 40m

Greenville

Sat 7/11

12:50 pm-10:50 pm

2 stops11h 00m

$423

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Fri 7/3

5:30 pm-7:35 am

2 stops37h 05m

Greenville

Fri 7/10

3:10 pm-10:15 pm

1 stop8h 05m

$426

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sat 6/13

6:02 am-2:18 pm

1 stop7h 16m

Greenville

Sat 6/20

5:25 pm-11:58 pm

1 stop7h 33m

$427

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Des Moines to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Des Moines and Greenville?

What is the cheapest month to fly to Greenville?

The month of October is another great option to travel to Greenville, with average flight prices from Des Moines averaging around $295.

Can stopping save me money on Des Moines to Greenville flights?

You could potentially save up to 60% on your flight if you consider stops on a Des Moines to Greenville flight.

When to book flights from Des Moines to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Greenville (DSM to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Greenville

Fastest flight time

4h 02m

Direct flights

None
The fastest flight from Des Moines to Greenville takes 4h 02m
There are no direct flights from Des Moines to Greenville. There are no popular flight routes from Des Moines to Greenville.
Search flight deals

Frequently asked questions about flying from Des Moines to Greenville

  • How far is Des Moines to Greenville by plane?

    Des Moines and Greenville are 765.4 mi apart from one another. A reasonable flight in good conditions will take 4h 02m.

  • When did momondo last update prices for flights from Des Moines Airport to Greenville Airport?

    Prices for flights from Des Moines Airport to Greenville Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Des Moines Airport to Greenville Airport?

  • How old do you have to be to fly from Des Moines Airport to Greenville Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Greenville?

Best airlines flying from Des Moines to Greenville

Compare and see reviews for airlines that fly from Des Moines to Greenville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $243Free CancellationRating
7.9
8,436 reviews
Search Delta flights
American AirlinesPriceFrom $304Free CancellationRating
7.1
11,631 reviews
Search American Airlines flights
United AirlinesPriceFrom $362Free CancellationRating
7.4
9,749 reviews
Search United Airlines flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Greer
Seneca
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Greenville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Greenville from Des Moines.

Can I find flights from Des Moines to Greenville with flexible booking policies on momondo?

All flight searches from Des Moines to Greenville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Greenville?

Once you have performed a search for Des Moines to Greenville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Greenville right now. Can momondo alert me if prices change?

Price alerts on flights to Greenville from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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