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Cheap flights from Des Moines to Greenville from $137

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Greenville departing on 11/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:34 am - 11:03 amDSM-GSP
4h 29m1 stop
Delta Logo
11:30 am - 7:34 pmGSP-DSM
9h 04m1 stop
$297Delta
Find Deal
Tue, Jan 20 - Tue, Jan 27
American Airlines Logo
1:16 pm - 11:26 pmDSM-GSP
9h 10m2 stops
American Airlines Logo
5:26 pm - 9:04 pmGSP-DSM
4h 38m1 stop
$302American Airlines
Find Deal
Tue, Jan 20 - Tue, Jan 27
American Airlines Logo
1:16 pm - 8:48 pmDSM-GSP
6h 32m2 stops
American Airlines Logo
6:00 am - 11:12 amGSP-DSM
6h 12m2 stops
$307American Airlines
Find Deal
Tue, Jan 20 - Tue, Jan 27
Delta Logo
7:34 am - 5:12 pmDSM-GSP
8h 38m1 stop
Delta Logo
11:30 am - 7:34 pmGSP-DSM
9h 04m1 stop
$313Delta
Find Deal
Thu, Jan 22 - Mon, Jan 26
United Airlines Logo
3:04 pm - 9:57 pmDSM-GSP
5h 53m1 stop
United Airlines Logo
11:49 am - 9:50 pmGSP-DSM
11h 01m2 stops
$318United Airlines
Find Deal
Thu, Jan 22 - Mon, Jan 26
Southwest Logo
8:35 am - 7:50 pmDSM-GSP
10h 15m2 stops
Southwest Logo
11:15 am - 7:20 pmGSP-DSM
9h 05m2 stops
$323Southwest
Find Deal
Thu, Jan 22 - Mon, Jan 26
Delta Logo
5:15 pm - 11:36 pmDSM-GSP
5h 21m1 stop
Delta Logo
6:45 am - 10:23 amGSP-DSM
4h 38m1 stop
$387Delta
Find Deal
Tue, Mar 31 - Wed, Apr 1
Delta Logo
3:17 pm - 10:06 pmDSM-GSP
5h 49m1 stop
Delta Logo
5:35 am - 10:42 amGSP-DSM
6h 07m1 stop
$407Delta
Find Deal
Thu, Nov 20 - Sun, Nov 23
United Airlines Logo
1:05 pm - 11:56 pmDSM-GSP
9h 51m2 stops
United Airlines Logo
4:17 pm - 11:44 pmGSP-DSM
8h 27m1 stop
$452United Airlines
Find Deal
Tue, Nov 11 - Fri, Nov 14
Southwest Logo
4:20 pm - 10:45 pmDSM-GSP
5h 25m2 stops
Southwest Logo
6:25 am - 1:40 pmGSP-DSM
8h 15m2 stops
$727Southwest
Find Deal
Fri, Mar 13 - Mon, Mar 16

United Airlines flights from Des Moines to Greenville

Our best United Airlines deals on Des Moines to Greenville flight tickets
United Airlines
Jan 22
DSM3:04 pmDes Moines
5h 53m
1 stop
GSP9:57 pmGreenville
Jan 26
GSP11:49 amGreenville
11h 01m
2 stops
DSM9:50 pmDes Moines
$318
Find similar
United Airlines
Nov 11
DSM1:05 pmDes Moines
9h 51m
2 stops
GSP11:56 pmGreenville
Nov 14
GSP4:17 pmGreenville
8h 27m
1 stop
DSM11:44 pmDes Moines
$452
Find similar
United Airlines
Nov 20
DSM1:05 pmDes Moines
9h 51m
2 stops
GSP11:56 pmGreenville
Nov 23
GSP9:10 amGreenville
6h 09m
1 stop
DSM2:19 pmDes Moines
$482
Find similar

American Airlines flights from Des Moines to Greenville

Our best American Airlines deals on Des Moines to Greenville flight tickets
American Airlines
Jan 20
DSM1:16 pmDes Moines
9h 10m
2 stops
GSP11:26 pmGreenville
Jan 27
GSP5:26 pmGreenville
4h 38m
1 stop
DSM9:04 pmDes Moines
$302
Find similar
American Airlines
Jan 20
DSM1:16 pmDes Moines
6h 32m
2 stops
GSP8:48 pmGreenville
Jan 27
GSP6:00 amGreenville
6h 12m
2 stops
DSM11:12 amDes Moines
$307
Find similar
American Airlines
Nov 11
DSM12:54 pmDes Moines
5h 07m
1 stop
GSP7:01 pmGreenville
Nov 14
GSP5:24 pmGreenville
7h 06m
1 stop
DSM11:30 pmDes Moines
$447
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Des Moines to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Des Moines to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Tue 1/20

5:34 am-11:03 am

1 stop4h 29m

Greenville

Tue 1/27

11:30 am-7:34 pm

1 stop9h 04m

$297

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Tue 1/20

1:16 pm-11:26 pm

2 stops9h 10m

Greenville

Tue 1/27

5:26 pm-9:04 pm

1 stop4h 38m

$302

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Tue 1/20

1:16 pm-8:48 pm

2 stops6h 32m

Greenville

Tue 1/27

6:00 am-11:12 am

2 stops6h 12m

$307

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 1/22

7:34 am-5:12 pm

1 stop8h 38m

Greenville

Mon 1/26

11:30 am-7:34 pm

1 stop9h 04m

$313

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 1/22

3:04 pm-9:57 pm

1 stop5h 53m

Greenville

Mon 1/26

11:49 am-9:50 pm

2 stops11h 01m

$318

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 1/22

8:35 am-7:50 pm

2 stops10h 15m

Greenville

Mon 1/26

11:15 am-7:20 pm

2 stops9h 05m

$323

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Tue 3/31

5:15 pm-11:36 pm

1 stop5h 21m

Greenville

Wed 4/1

6:45 am-10:23 am

1 stop4h 38m

$387

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 11/20

3:17 pm-10:06 pm

1 stop5h 49m

Greenville

Sun 11/23

5:35 am-10:42 am

1 stop6h 07m

$407

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Tue 11/11

1:05 pm-11:56 pm

2 stops9h 51m

Greenville

Fri 11/14

4:17 pm-11:44 pm

1 stop8h 27m

$452

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Fri 3/13

4:20 pm-10:45 pm

2 stops5h 25m

Greenville

Mon 3/16

6:25 am-1:40 pm

2 stops8h 15m

$727

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Des Moines to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Greenville?

The month of October is another great option to travel to Greenville, with average flight prices from Des Moines averaging around $295.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Friday is the cheapest day to fly to Greenville from Des Moines. The lowest ticket price found for a Friday departure recently was $349. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Tuesday because tickets tend to average around $608. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the afternoon. Flights from Des Moines to Greenville during this time can be as low as $373. Flights to Greenville are more costly in the morning, with an average ticket price of $437. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

Can stopping save me money on Des Moines to Greenville flights?

You could potentially save up to 60% on your flight if you consider stops on a Des Moines to Greenville flight.

When to book flights from Des Moines to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Greenville (DSM to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Greenville

Direct flights

None
There are no direct flights from Des Moines to Greenville. There are no popular flight routes from Des Moines to Greenville.
Search flight deals

  • How far is Des Moines to Greenville by plane?

    Des Moines and Greenville are 765.4 mi apart from one another. A reasonable flight in good conditions will take 4h 29m.

  • When did momondo last update prices for flights from Des Moines Airport to Greenville Airport?

    Prices for flights from Des Moines Airport to Greenville Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Des Moines Airport to Greenville Airport?

  • How old do you have to be to fly from Des Moines Airport to Greenville Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Greenville?

Best airlines flying from Des Moines to Greenville

Compare and see reviews for airlines that fly from Des Moines to Greenville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $243Free CancellationRating
7.9
7,998 reviews
Search Delta flights
American AirlinesPriceFrom $296Free CancellationRating
7.2
11,035 reviews
Search American Airlines flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Seneca
Greer
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Greenville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Greenville from Des Moines.

Can I find flights from Des Moines to Greenville with flexible booking policies on momondo?

All flight searches from Des Moines to Greenville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Greenville?

Once you have performed a search for Des Moines to Greenville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Greenville right now. Can momondo alert me if prices change?

Price alerts on flights to Greenville from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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