What is the cheapest airline that flies from Des Moines to Greenville?

Allegiant Air, Delta, and Southwest are the most popular carriers operating from Des Moines to Greenville

When did momondo last update prices for flights from Des Moines Airport to Greenville Airport?

Prices for flights from Des Moines Airport to Greenville Airport are refreshed on a daily basis.

How many operators does momondo search for flights from Des Moines Airport to Greenville Airport?

The number of operators available for flights from Des Moines Airport to Greenville Airport is 2 as of January 2026.

How old do you have to be to fly from Des Moines Airport to Greenville Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Greenville Airport.

What documentation or ID do you need to fly to Greenville Airport?

The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$148 Cheap Flights from Des Moines to Greenville in 2026

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Find the cheapest flights from Des Moines to Greenville

Round-trip

One-way

Cheap round-trip flights

Enter your travel dates to find the best prices.

1:10 pm - 8:47 pm

DSM

GSP

6h 37m1 stop

6:30 am - 12:29 pm

GSP

DSM

6h 59m1 stop

$312United Airlines

Tue, Apr 7 - Sun, Apr 12

1:48 pm - 10:05 pm

DSM

GSP

7h 17m1 stop

8:21 pm - 11:40 pm

GSP

DSM

4h 19m1 stop

$338American Airlines

Thu, Feb 19 - Sun, Feb 22

1:10 pm - 10:45 pm

DSM

GSP

8h 35m2 stops

6:30 am - 12:29 pm

GSP

DSM

6h 59m1 stop

$349United Airlines

Tue, Apr 7 - Sun, Apr 12

1:10 pm - 10:45 pm

DSM

GSP

8h 35m2 stops

6:30 am - 12:29 pm

GSP

DSM

6h 59m1 stop

$351United Airlines

Tue, Apr 7 - Sun, Apr 12

6:00 am - 3:03 pm

DSM

GSP

8h 03m2 stops

5:20 am - 12:55 pm

GSP

DSM

8h 35m2 stops

$371American Airlines

Tue, Apr 7 - Sun, Apr 12

8:30 am - 3:54 pm

DSM

GSP

6h 24m1 stop

5:17 pm - 7:48 pm

GSP

DSM

27h 31m2 stops

$382Multiple Airlines

Thu, Feb 19 - Sun, Feb 22

2:18 pm - 11:57 pm

DSM

GSP

8h 39m2 stops

12:35 pm - 8:47 pm

GSP

DSM

9h 12m1 stop

$392American Airlines

Wed, Apr 8 - Mon, Apr 13

2:27 pm - 9:18 pm

DSM

GSP

5h 51m1 stop

7:39 pm - 11:59 pm

GSP

DSM

5h 20m1 stop

$415American Airlines

Thu, Jun 25 - Mon, Jun 29

1:16 pm - 10:16 pm

DSM

GSP

8h 00m1 stop

7:50 am - 4:24 pm

GSP

DSM

9h 34m1 stop

$462American Airlines

Thu, Jan 22 - Mon, Jan 26

7:43 am - 5:09 pm

DSM

GSP

8h 26m2 stops

7:50 am - 9:04 pm

GSP

DSM

14h 14m1 stop

$467American Airlines

Thu, Jan 22 - Mon, Jan 26

American Airlines flights from Des Moines to Greenville

Our best American Airlines deals on Des Moines to Greenville flight tickets

American Airlines

Feb 19

DSM1:48 pmDes Moines

7h 17m

1 stop

GSP10:05 pmGreenville

Feb 22

GSP8:21 pmGreenville

4h 19m

1 stop

DSM11:40 pmDes Moines

$338

American Airlines

Apr 7

DSM11:58 amDes Moines

8h 15m

2 stops

GSP9:13 pmGreenville

Apr 12

GSP5:20 amGreenville

8h 35m

2 stops

DSM12:55 pmDes Moines

$371

American Airlines

Apr 8

DSM2:18 pmDes Moines

8h 39m

2 stops

GSP11:57 pmGreenville

Apr 13

GSP12:35 pmGreenville

9h 12m

1 stop

DSM8:47 pmDes Moines

$392

United Airlines flights from Des Moines to Greenville

Our best United Airlines deals on Des Moines to Greenville flight tickets

United Airlines

Apr 7

DSM1:10 pmDes Moines

6h 37m

1 stop

GSP8:47 pmGreenville

Apr 12

GSP6:30 amGreenville

6h 59m

1 stop

DSM12:29 pmDes Moines

$312

United Airlines

Apr 7

DSM1:10 pmDes Moines

8h 35m

2 stops

GSP10:45 pmGreenville

Apr 12

GSP6:30 amGreenville

6h 59m

1 stop

DSM12:29 pmDes Moines

$349

United Airlines

Apr 7

DSM1:10 pmDes Moines

8h 35m

2 stops

GSP10:45 pmGreenville

Apr 12

GSP6:30 amGreenville

6h 59m

1 stop

DSM12:29 pmDes Moines

$351

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Tue 4/7

1:10 pm-8:47 pm

1 stop6h 37m

Greenville

Sun 4/12

6:30 am-12:29 pm

1 stop6h 59m

$312

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 2/19

1:48 pm-10:05 pm

1 stop7h 17m

Greenville

Sun 2/22

8:21 pm-11:40 pm

1 stop4h 19m

$338

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Tue 4/7

1:10 pm-10:45 pm

2 stops8h 35m

Greenville

Sun 4/12

6:30 am-12:29 pm

1 stop6h 59m

$349

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Tue 4/7

1:10 pm-10:45 pm

2 stops8h 35m

Greenville

Sun 4/12

6:30 am-12:29 pm

1 stop6h 59m

$351

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Tue 4/7

6:00 am-3:03 pm

2 stops8h 03m

Greenville

Sun 4/12

5:20 am-12:55 pm

2 stops8h 35m

$371

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 2/19

8:30 am-3:54 pm

1 stop6h 24m

Greenville

Sun 2/22

5:17 pm-7:48 pm

2 stops27h 31m

$382

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Wed 4/8

2:18 pm-11:57 pm

2 stops8h 39m

Greenville

Mon 4/13

12:35 pm-8:47 pm

1 stop9h 12m

$392

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 6/25

2:27 pm-9:18 pm

1 stop5h 51m

Greenville

Mon 6/29

7:39 pm-11:59 pm

1 stop5h 20m

$415

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 1/22

1:16 pm-10:16 pm

1 stop8h 00m

Greenville

Mon 1/26

7:50 am-4:24 pm

1 stop9h 34m

$462

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 1/22

7:43 am-5:09 pm

2 stops8h 26m

Greenville

Mon 1/26

7:50 am-9:04 pm

1 stop14h 14m

$467

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Des Moines to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Greenville?

The month of October is another great option to travel to Greenville, with average flight prices from Des Moines averaging around $295.

Can stopping save me money on Des Moines to Greenville flights?

You could potentially save up to 41% on your flight if you consider stops on a Des Moines to Greenville flight.

When to book flights from Des Moines to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Greenville according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Greenville (DSM to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Greenville

Fastest flight time	4h 26m
Direct flights	None

The fastest flight from Des Moines to Greenville takes 4h 26m

There are no direct flights from Des Moines to Greenville. There are no popular flight routes from Des Moines to Greenville.

Search flight deals

How far is Des Moines to Greenville by plane?
Des Moines and Greenville are 765.4 mi apart from one another. A reasonable flight in good conditions will take 4h 26m.
When did momondo last update prices for flights from Des Moines Airport to Greenville Airport?
Prices for flights from Des Moines Airport to Greenville Airport are refreshed on a daily basis.
How many operators does momondo search for flights from Des Moines Airport to Greenville Airport?
The number of operators available for flights from Des Moines Airport to Greenville Airport is 2 as of January 2026.
How old do you have to be to fly from Des Moines Airport to Greenville Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Greenville Airport.
What documentation or ID do you need to fly to Greenville Airport?
The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Des Moines to Greenville?
Based on momondo bookings for this flight route, the most popular airline on flight routes from Des Moines to Greenville is American Airlines (66% of total bookings). The next most popular airline is Delta (34%).

Best airlines flying from Des Moines to Greenville

Compare and see reviews for airlines that fly from Des Moines to Greenville with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $243	Free Cancellation	Rating 7.9 8,025 reviews		Search Delta flights
American Airlines	PriceFrom $296	Free Cancellation	Rating 7.2 11,094 reviews		Search American Airlines flights

Anderson

Simpsonville

Greenwood

Seneca

Greer

Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Greenville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Greenville from Des Moines.

Can I find flights from Des Moines to Greenville with flexible booking policies on momondo?

All flight searches from Des Moines to Greenville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Des Moines to Greenville?

Once you have performed a search for Des Moines to Greenville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Des Moines to Greenville right now. Can momondo alert me if prices change?

Price alerts on flights to Greenville from Des Moines are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.