Cheap flights from Cleveland to St. Louis from $54

In general, October is the cheapest month to fly from Cleveland to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $286. The month of July is another great option to travel to St. Louis, with average flight prices from Cleveland averaging around $297.

The cheapest day to depart on your flight to St. Louis is on a Saturday when prices can be found for as low as $387. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $471. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

Flying to St. Louis from Cleveland in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $361 when looking at flights departing in the afternoon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $431 per ticket.

Fly from Cleveland Hopkins Intl to Lambert-St Louis for the best Cleveland Hopkins Intl - Lambert-St Louis flight prices

You are more likely to see cheaper flights to St. Louis from Cleveland when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $365 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from Cleveland for as low as $221 on momondo.

There is only 1 cabin class available to choose from on Cleveland to St. Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 58% on your flight if you consider stops on a Cleveland to St. Louis flight.

As of October 2026, prices for Cleveland to St. Louis flights are approximately 49% cheaper when compared to flights at the same time last year.

Southwest, Frontier, and Delta are the most popular carriers operating from Cleveland Hopkins Intl to Lambert-St Louis

Southwest, Delta and United Airlines are the top three most popular airlines that fly to St. Louis from Cleveland according to our data. Southwest is the first choice among our users, with 56% of people opting to fly with this airline when traveling to St. Louis. Keep in mind that there are 5 different airlines that fly to St. Louis on a routine basis, so you have a few additional options to choose from.

Chicago (ORD) was the most common stop: 80% of momondo users choosing 1-stop flights on this route connected there.

Flights via Chicago (ORD) offer the lowest average round-trip price of $336.

Flights connecting via Chicago (MDW) have the shortest average one-way travel time: 3h 25m.

Chicago (MDW) has the shortest average layover time for this route: 1h 00m.