Cheap flights from Cleveland to St. Louis from $55

In general, October is the cheapest month to fly from Cleveland to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $247. The month of July is another great option to travel to St. Louis, with average flight prices from Cleveland averaging around $297.

The cheapest day to depart on your flight to St. Louis is on a Wednesday when prices can be found for as low as $387. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $470. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

Flying to St. Louis from Cleveland at noon is the least expensive time of day to depart. momondo users have found prices as low as $343 when looking at flights departing at noon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $426 per ticket.

Fly from Cleveland Hopkins Intl to Lambert-St Louis for the best Cleveland Hopkins Intl - Lambert-St Louis flight prices

You are more likely to see cheaper flights to St. Louis from Cleveland when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $358 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from Cleveland for as low as $236 on momondo.

There is only 1 cabin class available to choose from on Cleveland to St. Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 51% on your flight if you consider stops on a Cleveland to St. Louis flight.

As of September 2026, prices for Cleveland to St. Louis flights are approximately 39% more expensive when compared to flights at the same time last year.

Southwest is the most popular carrier operating from Cleveland Hopkins Intl to Lambert-St Louis

Southwest, Delta and United Airlines are the top three most popular airlines that fly to St. Louis from Cleveland according to our data. Southwest is the first choice among our users, with 54% of people opting to fly with this airline when traveling to St. Louis. Keep in mind that there are 5 different airlines that fly to St. Louis on a routine basis, so you have a few additional options to choose from.

Chicago (ORD) was the most common stop: 80% of momondo users choosing 1-stop flights on this route connected there.

Flights via Chicago (ORD) offer the lowest average round-trip price of $336.

Flights connecting via Chicago (MDW) have the shortest average one-way travel time: 3h 25m.

Chicago (MDW) has the shortest average layover time for this route: 1h 00m.

As of September 2026, there are 1 flights per day flying from Cleveland to St. Louis. The most common time of day flights depart is 7:00AM, with 75% of flights taking off at noon.

As of September 2026, there are 11 flights per week flying from Cleveland to St. Louis. The most common day of the week flights depart is Thu, with 27% of flights taking off on this day.