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Cheap flights from Cleveland to Florence from $438

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Cleveland to Florence departing on 12/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Cleveland to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
12:20 pm - 12:03 amCLE-FLO
11h 43m2 stops
American Airlines Logo
6:31 pm - 11:50 amFLO-CLE
17h 19m2 stops
$498American Airlines
Find Deal
Thu, Dec 11 - Sat, Dec 13
American Airlines Logo
1:08 pm - 6:05 pmCLE-FLO
4h 57m1 stop
American Airlines Logo
6:31 pm - 12:45 amFLO-CLE
6h 14m1 stop
$518American Airlines
Find Deal
Thu, Dec 11 - Sat, Dec 13
American Airlines Logo
5:40 pm - 12:03 amCLE-FLO
6h 23m1 stop
American Airlines Logo
5:15 am - 11:59 amFLO-CLE
6h 44m2 stops
$523American Airlines
Find Deal
Thu, Dec 11 - Sat, Dec 13
American Airlines Logo
5:40 pm - 12:03 amCLE-FLO
6h 23m1 stop
American Airlines Logo
11:16 am - 5:10 pmFLO-CLE
5h 54m1 stop
$545American Airlines
Find Deal
Thu, Dec 11 - Sun, Dec 14
American Airlines Logo
6:17 am - 10:51 amCLE-FLO
4h 34m1 stop
American Airlines Logo
11:16 am - 8:13 pmFLO-CLE
8h 57m2 stops
$550American Airlines
Find Deal
Thu, Dec 11 - Sun, Dec 14
American Airlines Logo
6:30 am - 10:45 amCLE-FLO
4h 15m1 stop
American Airlines Logo
10:29 am - 3:43 pmFLO-CLE
5h 14m1 stop
$559American Airlines
Find Deal
Thu, Nov 20 - Mon, Nov 24
American Airlines Logo
1:16 pm - 11:41 pmCLE-FLO
10h 25m2 stops
American Airlines Logo
6:15 am - 12:33 pmFLO-CLE
6h 18m1 stop
$564American Airlines
Find Deal
Thu, Nov 20 - Mon, Nov 24
American Airlines Logo
11:11 am - 6:07 pmCLE-FLO
6h 56m2 stops
American Airlines Logo
10:29 am - 7:11 pmFLO-CLE
8h 42m2 stops
$569American Airlines
Find Deal
Thu, Nov 20 - Mon, Nov 24
American Airlines Logo
6:45 am - 10:24 amCLE-FLO
3h 39m1 stop
American Airlines Logo
2:30 pm - 7:33 pmFLO-CLE
5h 03m1 stop
$925American Airlines
Find Deal
Sun, Mar 22 - Mon, Mar 23
American Airlines Logo
8:15 pm - 11:38 pmCLE-FLO
3h 23m1 stop
American Airlines Logo
2:30 pm - 10:41 pmFLO-CLE
8h 11m2 stops
$930American Airlines
Find Deal
Sun, Mar 22 - Mon, Mar 23

American Airlines flights from Cleveland to Florence, South Carolina

Our best American Airlines deals on Cleveland to Florence, South Carolina flight tickets
American Airlines
Dec 11
CLE12:20 pmCleveland Hopkins Intl
11h 43m
2 stops
FLO12:03 amFlorence
Dec 13
FLO6:31 pmFlorence
17h 19m
2 stops
CLE11:50 amCleveland Hopkins Intl
$498
Find similar
American Airlines
Dec 11
CLE1:08 pmCleveland Hopkins Intl
4h 57m
1 stop
FLO6:05 pmFlorence
Dec 13
FLO6:31 pmFlorence
6h 14m
1 stop
CLE12:45 amCleveland Hopkins Intl
$518
Find similar
American Airlines
Dec 11
CLE5:40 pmCleveland Hopkins Intl
6h 23m
1 stop
FLO12:03 amFlorence
Dec 13
FLO5:15 amFlorence
6h 44m
2 stops
CLE11:59 amCleveland Hopkins Intl
$523
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Cleveland to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 5, 2025.
Use the filters below to find and compare flights from Cleveland to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Thu 12/11

12:20 pm-12:03 am

2 stops11h 43m

Florence

Sat 12/13

6:31 pm-11:50 am

2 stops17h 19m

$498

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Thu 12/11

1:08 pm-6:05 pm

1 stop4h 57m

Florence

Sat 12/13

6:31 pm-12:45 am

1 stop6h 14m

$518

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Thu 12/11

5:40 pm-12:03 am

1 stop6h 23m

Florence

Sat 12/13

5:15 am-11:59 am

2 stops6h 44m

$523

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Thu 12/11

5:40 pm-12:03 am

1 stop6h 23m

Florence

Sun 12/14

11:16 am-5:10 pm

1 stop5h 54m

$545

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Thu 12/11

6:17 am-10:51 am

1 stop4h 34m

Florence

Sun 12/14

11:16 am-8:13 pm

2 stops8h 57m

$550

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Thu 11/20

6:30 am-10:45 am

1 stop4h 15m

Florence

Mon 11/24

10:29 am-3:43 pm

1 stop5h 14m

$559

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Thu 11/20

1:16 pm-11:41 pm

2 stops10h 25m

Florence

Mon 11/24

6:15 am-12:33 pm

1 stop6h 18m

$564

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Thu 11/20

11:11 am-6:07 pm

2 stops6h 56m

Florence

Mon 11/24

10:29 am-7:11 pm

2 stops8h 42m

$569

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Sun 3/22

6:45 am-10:24 am

1 stop3h 39m

Florence

Mon 3/23

2:30 pm-7:33 pm

1 stop5h 03m

$925

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Sun 3/22

8:15 pm-11:38 pm

1 stop3h 23m

Florence

Mon 3/23

2:30 pm-10:41 pm

2 stops8h 11m

$930

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Cleveland to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Cleveland Hopkins Intl to Florence?

American Airlines is the most popular carrier operating from Cleveland Hopkins Intl to Florence

What airlines fly to Florence, South Carolina?

American Airlines, Breeze Airways and Delta are the top three most popular airlines that fly to Florence, South Carolina from Cleveland according to our data. American Airlines is the first choice among our users, with 34% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 8 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Cleveland to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Cleveland to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Cleveland to Florence, South Carolina (CLE to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Cleveland to Florence, South Carolina

Direct flights

None
There are no direct flights from Cleveland to Florence, South Carolina. There are no popular flight routes from Cleveland to Florence, South Carolina.
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  • How far is Cleveland Hopkins Intl to Florence by plane?

    There are 515.1 mi between Cleveland Hopkins Intl and Florence. In terms of flight time, this usually takes a little over 3h 23m.

  • When did momondo last update prices for flights from Cleveland Hopkins Intl Airport to Florence Airport?

    Prices for flights from Cleveland Hopkins Intl Airport to Florence Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Cleveland Hopkins Intl Airport to Florence Airport?

  • How old do you have to be to fly from Cleveland Hopkins Intl Airport to Florence Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Cleveland Hopkins Intl Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The necessary travel and health documents for your Florence Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Cleveland to Florence, South Carolina?

Best airlines flying from Cleveland to Florence, South Carolina

Compare and see reviews for airlines that fly from Cleveland to Florence, South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $325Free CancellationRating
7.2
11,042 reviews
Search American Airlines flights

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Cleveland to Florence?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Florence from Cleveland.

Can I find flights from Cleveland to Florence with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Florence from Cleveland with this policy.

How can momondo help me find flights from Cleveland to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Cleveland to Florence.

I’m not ready to book a flight from Cleveland to Florence right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Cleveland to Florence flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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