Cheap flights from Chicago to St. Louis from $49

In general, December is the cheapest month to fly from Chicago to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $217. The month of November is another great option to travel to St. Louis, with average flight prices from Chicago averaging around $240.

The cheapest day to depart on your flight to St. Louis is on a Saturday when prices can be found for as low as $307. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $507. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

Flying to St. Louis from Chicago at noon is the least expensive time of day to depart. momondo users have found prices as low as $335 when looking at flights departing at noon. In the evening is when there is more demand to fly to St. Louis, so prices are often more expensive at around $467 per ticket.

Fly from Chicago O'Hare Intl to Lambert-St Louis for the best Chicago - Lambert-St Louis flight prices

You are more likely to see cheaper flights to St. Louis from Chicago when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $353 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from Chicago for as low as $165 on momondo.

There are 4 cabin classes available to choose from on Chicago to Lambert-St Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

No. A direct flight is the cheapest option for a flight between Chicago to St. Louis.

As of April 2026, prices for Chicago to St. Louis flights are approximately 38% more expensive when compared to flights at the same time last year.

Southwest and Delta are the most popular carriers operating from Chicago to Lambert-St Louis

United Airlines, American Airlines and Southern / Mokulele are the top three most popular airlines that fly to St. Louis from Chicago according to our data. United Airlines is the first choice among our users, with 55% of people opting to fly with this airline when traveling to St. Louis. Keep in mind that there are 5 different airlines that fly to St. Louis on a routine basis, so you have a few additional options to choose from.

Historically, on average around 18% of flights between Chicago and St. Louis have experienced a delay on any given week. The average delay length over the past 12 months has been 118 minutes.

Generally, flights departing in the morning tend to experience fewer delays. Flights in the evening have, in the past, seen delays more frequently in comparison.

Tuesday is statistically the day of the week which experiences the fewest number of delays on this flight route. Sunday has historically seen more delays on average compared to the rest of the week.

According to our data, Southwest have had the least number of delays on this route over the last 12 months; with about 12% of their flights experiencing any sort of delay.

Quincy (UIN) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

Flights via Burlington (BRL) offer the lowest average round-trip price of $156.

Flights connecting via Quincy (UIN) have the shortest average one-way travel time: 3h 35m.

Quincy (UIN) has the shortest average layover time for this route: 0h 38m.

The number of flights available between Chicago and St. Louis is 68 per day as of April 2026. The most frequent departure time is 6:00PM, with 51% of daily flights leaving in the evening.

As of April 2026, there are 479 flights per week flying from Chicago to St. Louis. The most common day of the week flights depart is Sun, with 17% of flights taking off on this day.