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Cheap flights from Buffalo to Panama City from $172

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to Panama City departing on 12/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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American Airlines Logo
7:13 pm - 11:49 pmBUF-ECP
5h 36m1 stop
American Airlines Logo
5:50 pm - 11:24 pmECP-BUF
4h 34m1 stop
$363American Airlines
Find Deal
Fri, Nov 28 - Wed, Dec 3
American Airlines Logo
6:00 am - 10:41 amBUF-ECP
5h 41m1 stop
American Airlines Logo
12:03 pm - 5:49 pmECP-BUF
4h 46m1 stop
$366American Airlines
Find Deal
Sat, Jan 3 - Sat, Jan 10
American Airlines Logo
7:13 pm - 11:49 pmBUF-ECP
5h 36m1 stop
American Airlines Logo
12:08 pm - 11:44 pmECP-BUF
10h 36m2 stops
$368American Airlines
Find Deal
Fri, Nov 28 - Wed, Dec 3
Delta Logo
12:05 pm - 3:26 pmBUF-ECP
4h 21m1 stop
Delta Logo
6:59 pm - 11:59 pmECP-BUF
4h 00m1 stop
$376Delta
Find Deal
Mon, Dec 1 - Mon, Dec 8
Delta Logo
6:10 am - 10:26 amBUF-ECP
5h 16m1 stop
Delta Logo
1:32 pm - 11:02 pmECP-BUF
8h 30m2 stops
$381Delta
Find Deal
Mon, Dec 1 - Mon, Dec 8
American Airlines Logo
7:15 pm - 11:53 pmBUF-ECP
5h 38m1 stop
American Airlines Logo
6:03 pm - 11:41 pmECP-BUF
4h 38m1 stop
$385American Airlines
Find Deal
Sun, Jan 4 - Sun, Jan 11
United Airlines Logo
6:30 am - 1:27 pmBUF-ECP
7h 57m1 stop
United Airlines Logo
6:30 am - 8:29 pmECP-BUF
12h 59m2 stops
$392United Airlines
Find Deal
Sat, Jan 3 - Sat, Jan 10
Southwest Logo
6:05 am - 2:30 pmBUF-ECP
9h 25m2 stops
Southwest Logo
2:35 pm - 9:50 pmECP-BUF
6h 15m2 stops
$447Southwest
Find Deal
Sat, Jan 3 - Sat, Jan 10
Southwest Logo
6:00 am - 2:50 pmBUF-ECP
9h 50m2 stops
Southwest Logo
7:35 am - 9:15 pmECP-BUF
12h 40m2 stops
$474Southwest
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Sun, Jan 4 - Sun, Jan 11
United Airlines Logo
6:00 am - 4:03 pmBUF-ECP
11h 03m2 stops
United Airlines Logo
6:30 am - 6:46 pmECP-BUF
11h 16m3 stops
$916United Airlines
Find Deal
Tue, Nov 18 - Sat, Nov 22

American Airlines flights from Buffalo to Panama City, Florida

Our best American Airlines deals on Buffalo to Panama City, Florida flight tickets
American Airlines
Nov 28
BUF7:13 pmBuffalo
5h 36m
1 stop
ECP11:49 pmPanama City NW Florida Beaches
Dec 3
ECP5:50 pmPanama City NW Florida Beaches
4h 34m
1 stop
BUF11:24 pmBuffalo
$363
Find similar
American Airlines
Jan 3
BUF6:00 amBuffalo
5h 41m
1 stop
ECP10:41 amPanama City NW Florida Beaches
Jan 10
ECP12:03 pmPanama City NW Florida Beaches
4h 46m
1 stop
BUF5:49 pmBuffalo
$366
Find similar
American Airlines
Nov 28
BUF7:13 pmBuffalo
5h 36m
1 stop
ECP11:49 pmPanama City NW Florida Beaches
Dec 3
ECP12:08 pmPanama City NW Florida Beaches
10h 36m
2 stops
BUF11:44 pmBuffalo
$368
Find similar

Southwest flights from Buffalo to Panama City, Florida

Our best Southwest deals on Buffalo to Panama City, Florida flight tickets
Southwest
Jan 3
BUF6:05 amBuffalo
9h 25m
2 stops
ECP2:30 pmPanama City NW Florida Beaches
Jan 10
ECP2:35 pmPanama City NW Florida Beaches
6h 15m
2 stops
BUF9:50 pmBuffalo
$447
Find similar
Southwest
Jan 4
BUF6:00 amBuffalo
9h 50m
2 stops
ECP2:50 pmPanama City NW Florida Beaches
Jan 11
ECP7:35 amPanama City NW Florida Beaches
12h 40m
2 stops
BUF9:15 pmBuffalo
$474
Find similar
Southwest
Dec 29
BUF8:50 amBuffalo
10h 05m
2 stops
ECP5:55 pmPanama City NW Florida Beaches
Jan 3
ECP6:00 pmPanama City NW Florida Beaches
4h 45m
1 stop
BUF11:45 pmBuffalo
$819
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Buffalo to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 5, 2025.
Use the filters below to find and compare flights from Buffalo to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Fri 11/28

7:13 pm-11:49 pm

1 stop5h 36m

Panama City NW Florida Beaches

Wed 12/3

5:50 pm-11:24 pm

1 stop4h 34m

$363

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Sat 1/3

6:00 am-10:41 am

1 stop5h 41m

Panama City NW Florida Beaches

Sat 1/10

12:03 pm-5:49 pm

1 stop4h 46m

$366

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Fri 11/28

7:13 pm-11:49 pm

1 stop5h 36m

Panama City NW Florida Beaches

Wed 12/3

12:08 pm-11:44 pm

2 stops10h 36m

$368

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Mon 12/1

12:05 pm-3:26 pm

1 stop4h 21m

Panama City NW Florida Beaches

Mon 12/8

6:59 pm-11:59 pm

1 stop4h 00m

$376

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Mon 12/1

6:10 am-10:26 am

1 stop5h 16m

Panama City NW Florida Beaches

Mon 12/8

1:32 pm-11:02 pm

2 stops8h 30m

$381

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Sun 1/4

7:15 pm-11:53 pm

1 stop5h 38m

Panama City NW Florida Beaches

Sun 1/11

6:03 pm-11:41 pm

1 stop4h 38m

$385

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Sat 1/3

6:30 am-1:27 pm

1 stop7h 57m

Panama City NW Florida Beaches

Sat 1/10

6:30 am-8:29 pm

2 stops12h 59m

$392

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Sat 1/3

6:05 am-2:30 pm

2 stops9h 25m

Panama City NW Florida Beaches

Sat 1/10

2:35 pm-9:50 pm

2 stops6h 15m

$447

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Sun 1/4

6:00 am-2:50 pm

2 stops9h 50m

Panama City NW Florida Beaches

Sun 1/11

7:35 am-9:15 pm

2 stops12h 40m

$474

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Tue 11/18

6:00 am-4:03 pm

2 stops11h 03m

Panama City NW Florida Beaches

Sat 11/22

6:30 am-6:46 pm

3 stops11h 16m

$916

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Buffalo to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from Buffalo is in February. Flight prices, which tend to average around $372, are often lower during this time because this is during the off-season. The month of July is another great option to travel to Panama City, Florida, with average flight prices from Buffalo averaging around $376.

What is the cheapest day to depart on your flight to Panama City, Florida?

Our data shows that Tuesday is the least expensive day to fly to Panama City, Florida. Tickets to fly out on this day can be as low as $356. On the other hand, Saturday is the most expensive day to depart from Buffalo because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $575.

How far in advance should I book a flight to Panama City, Florida?

You are more likely to see cheaper flights to Panama City, Florida from Buffalo when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City, Florida for around $440 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City, Florida from Buffalo for as low as $389 on momondo.

Can stopping save me money on Buffalo to Panama City, Florida flights?

You could potentially save up to 64% on your flight if you consider stops on a Buffalo to Panama City, Florida flight.

When to book flights from Buffalo to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Buffalo to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Buffalo to Panama City, Florida (BUF to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Panama City, Florida

Direct flights

None
There are no direct flights from Buffalo to Panama City, Florida. There are no popular flight routes from Buffalo to Panama City, Florida.
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  • How far is Buffalo to Panama City NW Florida Beaches by plane?

    A flight from Buffalo to Panama City NW Florida Beaches will travel around 955.1 mi. By plane, this route typically takes 4h 21m.

  • When did momondo last update prices for flights from Buffalo Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Buffalo Airport to Panama City NW Florida Beaches Airport were last updated today.

  • How many operators does momondo search for flights from Buffalo Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Buffalo Airport to Panama City NW Florida Beaches Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Buffalo Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The required travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City NW Florida Beaches Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Buffalo to Panama City, Florida?

Best airlines flying from Buffalo to Panama City, Florida

Compare and see reviews for airlines that fly from Buffalo to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $270Free CancellationRating
7.9
8,004 reviews
Search Delta flights
American AirlinesPriceFrom $292Free CancellationRating
7.2
11,042 reviews
Search American Airlines flights
SouthwestPriceFrom $381Free CancellationRating
8.0
4,240 reviews
Search Southwest flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to Panama City?

It is quick and easy to find Buffalo to Panama City flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama City that suits you.

Can I find flights from Buffalo to Panama City with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama City from Buffalo which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Buffalo to Panama City?

Once all potential Buffalo to Panama City flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Buffalo to Panama City right now. Can momondo alert me if prices change?

Price alerts on flights to Panama City from Buffalo are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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