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Cheap flights from Buffalo to Panama City from $171

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to Panama City departing on 3/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Buffalo to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
3:10 pm - 8:25 pm
BUF
-
ECP
6h 15m
2 stops
Southwest Logo
7:15 am - 2:35 pm
ECP
-
BUF
6h 20m
2 stops
$340Southwest
Tue, Apr 14 - Tue, Apr 21
Delta Logo
6:01 am - 12:10 pm
BUF
-
ECP
7h 09m
1 stop
Delta Logo
6:43 pm - 11:46 pm
ECP
-
BUF
4h 03m
1 stop
$341Delta
Mon, Mar 2 - Mon, Mar 9
Delta Logo
10:23 am - 7:47 pm
BUF
-
ECP
10h 24m
2 stops
Delta Logo
5:30 pm - 9:42 am
ECP
-
BUF
15h 12m
2 stops
$345Delta
Wed, Mar 11 - Wed, Mar 18
Delta Logo
6:01 am - 1:20 pm
BUF
-
ECP
8h 19m
2 stops
Delta Logo
6:43 pm - 11:46 pm
ECP
-
BUF
4h 03m
1 stop
$346Delta
Mon, Mar 2 - Mon, Mar 9
American Airlines Logo
4:04 pm - 11:49 pm
BUF
-
ECP
8h 45m
2 stops
American Airlines Logo
1:20 pm - 10:50 pm
ECP
-
BUF
8h 30m
2 stops
$351American Airlines
Mon, Mar 2 - Mon, Mar 9
American Airlines Logo
7:28 pm - 11:46 pm
BUF
-
ECP
5h 18m
1 stop
American Airlines Logo
7:21 am - 1:05 pm
ECP
-
BUF
4h 44m
1 stop
$353American Airlines
Wed, Apr 29 - Mon, May 4
Delta Logo
1:30 pm - 12:14 pm
BUF
-
ECP
23h 44m
1 stop
Delta Logo
6:47 pm - 11:59 pm
ECP
-
BUF
4h 12m
1 stop
$361Delta
Sat, May 9 - Mon, May 18
American Airlines Logo
7:28 pm - 11:46 pm
BUF
-
ECP
5h 18m
1 stop
American Airlines Logo
3:38 pm - 9:34 pm
ECP
-
BUF
4h 56m
1 stop
$363American Airlines
Sun, Apr 26 - Sat, May 2
Delta Logo
6:00 am - 10:15 am
BUF
-
ECP
5h 15m
1 stop
Delta Logo
5:49 am - 11:01 am
ECP
-
BUF
4h 12m
1 stop
$364Delta
Sun, Apr 26 - Sat, May 2
Delta Logo
6:02 am - 3:36 pm
BUF
-
ECP
10h 34m
2 stops
Delta Logo
5:30 pm - 11:46 pm
ECP
-
BUF
5h 16m
1 stop
$366Delta
Wed, Mar 11 - Wed, Mar 18

Southwest flights from Buffalo to Panama City, Florida

Our best Southwest deals on Buffalo to Panama City, Florida flight tickets
Southwest
Apr 14
BUF3:10 pmBuffalo
6h 15m
2 stops
ECP8:25 pmPanama City NW Florida Beaches
Apr 21
ECP7:15 amPanama City NW Florida Beaches
6h 20m
2 stops
BUF2:35 pmBuffalo
$340
Southwest
May 9
BUF2:00 pmBuffalo
4h 50m
1 stop
ECP5:50 pmPanama City NW Florida Beaches
May 17
ECP5:35 amPanama City NW Florida Beaches
7h 40m
2 stops
BUF2:15 pmBuffalo
$418
Southwest
May 9
BUF12:30 pmBuffalo
7h 30m
2 stops
ECP7:00 pmPanama City NW Florida Beaches
May 17
ECP5:35 amPanama City NW Florida Beaches
7h 40m
2 stops
BUF2:15 pmBuffalo
$424

United Airlines flights from Buffalo to Panama City, Florida

Our best United Airlines deals on Buffalo to Panama City, Florida flight tickets
United Airlines
Mar 11
BUF7:00 amBuffalo
7h 14m
1 stop
ECP1:14 pmPanama City NW Florida Beaches
Mar 14
ECP2:10 pmPanama City NW Florida Beaches
5h 36m
1 stop
BUF8:46 pmBuffalo
$402
United Airlines
Mar 11
BUF1:52 pmBuffalo
9h 05m
2 stops
ECP9:57 pmPanama City NW Florida Beaches
Mar 14
ECP2:10 pmPanama City NW Florida Beaches
5h 36m
1 stop
BUF8:46 pmBuffalo
$426
United Airlines
Mar 3
BUF7:00 amBuffalo
10h 11m
2 stops
ECP4:11 pmPanama City NW Florida Beaches
Mar 4
ECP1:01 pmPanama City NW Florida Beaches
9h 43m
2 stops
BUF11:44 pmBuffalo
$439

momondo Fare Finder

 
Customize your flight search to find flights from Buffalo to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 9, 2026.
Use the filters below to find and compare flights from Buffalo to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Tue 4/14

3:10 pm-8:25 pm

2 stops6h 15m

Panama City NW Florida Beaches

Tue 4/21

7:15 am-2:35 pm

2 stops6h 20m

$340

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Mon 3/2

6:01 am-12:10 pm

1 stop7h 09m

Panama City NW Florida Beaches

Mon 3/9

6:43 pm-11:46 pm

1 stop4h 03m

$341

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Wed 3/11

10:23 am-7:47 pm

2 stops10h 24m

Panama City NW Florida Beaches

Wed 3/18

5:30 pm-9:42 am

2 stops15h 12m

$345

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Mon 3/2

6:01 am-1:20 pm

2 stops8h 19m

Panama City NW Florida Beaches

Mon 3/9

6:43 pm-11:46 pm

1 stop4h 03m

$346

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Mon 3/2

4:04 pm-11:49 pm

2 stops8h 45m

Panama City NW Florida Beaches

Mon 3/9

1:20 pm-10:50 pm

2 stops8h 30m

$351

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Wed 4/29

7:28 pm-11:46 pm

1 stop5h 18m

Panama City NW Florida Beaches

Mon 5/4

7:21 am-1:05 pm

1 stop4h 44m

$353

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Sat 5/9

1:30 pm-12:14 pm

1 stop23h 44m

Panama City NW Florida Beaches

Mon 5/18

6:47 pm-11:59 pm

1 stop4h 12m

$361

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Sun 4/26

7:28 pm-11:46 pm

1 stop5h 18m

Panama City NW Florida Beaches

Sat 5/2

3:38 pm-9:34 pm

1 stop4h 56m

$363

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Sun 4/26

6:00 am-10:15 am

1 stop5h 15m

Panama City NW Florida Beaches

Sat 5/2

5:49 am-11:01 am

1 stop4h 12m

$364

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Wed 3/11

6:02 am-3:36 pm

2 stops10h 34m

Panama City NW Florida Beaches

Wed 3/18

5:30 pm-11:46 pm

1 stop5h 16m

$366

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Buffalo to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from Buffalo is in November. Flight prices, which tend to average around $349, are often lower during this time because this is during the off-season. The month of July is another great option to travel to Panama City, Florida, with average flight prices from Buffalo averaging around $376.

Can stopping save me money on Buffalo to Panama City, Florida flights?

You could potentially save up to 54% on your flight if you consider stops on a Buffalo to Panama City, Florida flight.

When to book flights from Buffalo to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Buffalo to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Buffalo to Panama City, Florida (BUF to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Panama City, Florida

Fastest flight time

4h 07m

Direct flights

None
The fastest flight from Buffalo to Panama City, Florida takes 4h 07m
There are no direct flights from Buffalo to Panama City, Florida. There are no popular flight routes from Buffalo to Panama City, Florida.
Search flight deals

  • How far is Buffalo to Panama City NW Florida Beaches by plane?

    A flight from Buffalo to Panama City NW Florida Beaches will travel around 955.1 mi. By plane, this route typically takes 4h 07m.

  • When did momondo last update prices for flights from Buffalo Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Buffalo Airport to Panama City NW Florida Beaches Airport were last updated today.

  • How many operators does momondo search for flights from Buffalo Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Buffalo Airport to Panama City NW Florida Beaches Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Buffalo Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The required travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City NW Florida Beaches Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Buffalo to Panama City, Florida?

Best airlines flying from Buffalo to Panama City, Florida

Compare and see reviews for airlines that fly from Buffalo to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $222Free CancellationRating
7.9
8,174 reviews
Search Delta flights
American AirlinesPriceFrom $292Free CancellationRating
7.2
11,258 reviews
Search American Airlines flights
SouthwestPriceFrom $381Free CancellationRating
8.0
4,282 reviews
Search Southwest flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to Panama City?

It is quick and easy to find Buffalo to Panama City flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama City that suits you.

Can I find flights from Buffalo to Panama City with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama City from Buffalo which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Buffalo to Panama City?

Once all potential Buffalo to Panama City flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Buffalo to Panama City right now. Can momondo alert me if prices change?

Price alerts on flights to Panama City from Buffalo are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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