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Cheap flights from Buffalo to Panama City from $135

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to Panama City departing on 9/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Buffalo to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
12:58 pm - 5:33 pmBUF  Buffalo-ECP Panama City NW Florida Beaches
5h 35m1 stop Charlotte Douglas
American Airlines Logo
6:03 pm - 11:41 pmECP  Panama City NW Florida Beaches-BUF Buffalo
4h 38m1 stop Charlotte Douglas
$269American Airlines
Mon, Feb 1 - Mon, Feb 8
Delta Logo
6:59 pm - 10:47 pmBUF  Buffalo-ECP Panama City NW Florida Beaches
4h 48m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:00 am - 11:15 amECP  Panama City NW Florida Beaches-BUF Buffalo
4h 15m1 stop Atlanta Hartsfield-Jackson
$269Delta
Sat, Feb 6 - Sat, Feb 13
Delta Logo
6:55 pm - 11:18 pmBUF  Buffalo-ECP Panama City NW Florida Beaches
5h 23m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:20 pm - 11:59 pmECP  Panama City NW Florida Beaches-BUF Buffalo
4h 39m1 stop Atlanta Hartsfield-Jackson
$293Delta
Wed, Oct 21 - Mon, Oct 26
Delta Logo
6:59 pm - 11:25 pmBUF  Buffalo-ECP Panama City NW Florida Beaches
5h 26m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:19 pm - 11:52 pmECP  Panama City NW Florida Beaches-BUF Buffalo
4h 33m1 stop Atlanta Hartsfield-Jackson
$306Delta
Fri, Oct 2 - Mon, Oct 5
American Airlines Logo
12:58 pm - 5:33 pmBUF  Buffalo-ECP Panama City NW Florida Beaches
5h 35m1 stop Charlotte Douglas
American Airlines Logo
6:03 pm - 11:41 pmECP  Panama City NW Florida Beaches-BUF Buffalo
4h 38m1 stop Charlotte Douglas
$325American Airlines
Mon, Feb 1 - Mon, Feb 8
American Airlines Logo
6:00 am - 12:51 pmBUF  Buffalo-ECP Panama City NW Florida Beaches
7h 51m1 stop Washington, D.C. Reagan-National
American Airlines Logo
7:15 am - 3:06 pmECP  Panama City NW Florida Beaches-BUF Buffalo
6h 51m1 stop Charlotte Douglas
$325American Airlines
Wed, Oct 21 - Mon, Oct 26
Southwest Logo
8:50 am - 1:55 pmBUF  Buffalo-ECP Panama City NW Florida Beaches
6h 05m1 stop Baltimore/Washington
Southwest Logo
5:55 am - 2:35 pmECP  Panama City NW Florida Beaches-BUF Buffalo
7h 40m2 stops Lambert-St Louis Baltimore/Washington
$360Southwest
Sat, Sep 26 - Sat, Oct 10
Southwest Logo
6:00 am - 10:40 amBUF  Buffalo-ECP Panama City NW Florida Beaches
5h 40m1 stop Baltimore/Washington
Southwest Logo
5:55 am - 2:35 pmECP  Panama City NW Florida Beaches-BUF Buffalo
7h 40m2 stops Lambert-St Louis Baltimore/Washington
$360Southwest
Sat, Oct 3 - Sat, Oct 10
United Airlines Logo
6:00 am - 4:38 pmBUF  Buffalo-ECP Panama City NW Florida Beaches
11h 38m2 stops Newark Houston George Bush Intcntl
United Airlines Logo
6:30 am - 9:07 pmECP  Panama City NW Florida Beaches-BUF Buffalo
13h 37m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
$375United Airlines
Wed, Sep 9 - Tue, Sep 15
United Airlines Logo
7:00 am - 1:13 pmBUF  Buffalo-ECP Panama City NW Florida Beaches
7h 13m1 stop Chicago O'Hare Intl
United Airlines Logo
6:30 am - 9:07 pmECP  Panama City NW Florida Beaches-BUF Buffalo
13h 37m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
$450United Airlines
Tue, Sep 8 - Tue, Sep 15

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Southwest flights from Buffalo to Panama City, Florida

Our best Southwest deals on Buffalo to Panama City, Florida flight tickets
Southwest
Sep 26
BUF8:50 amBuffalo
6h 05m
1 stop
ECP1:55 pmPanama City NW Florida Beaches
Oct 10
ECP5:55 amPanama City NW Florida Beaches
7h 40m
2 stops
BUF2:35 pmBuffalo
$360
Southwest
Sep 26
BUF5:45 amBuffalo
9h 20m
2 stops
ECP2:05 pmPanama City NW Florida Beaches
Oct 10
ECP5:55 amPanama City NW Florida Beaches
7h 40m
2 stops
BUF2:35 pmBuffalo
$365
Southwest
Feb 1
BUF5:50 amBuffalo
10h 25m
2 stops
ECP3:15 pmPanama City NW Florida Beaches
Feb 8
ECP7:50 amPanama City NW Florida Beaches
9h 15m
2 stops
BUF6:05 pmBuffalo
$388

United Airlines flights from Buffalo to Panama City, Florida

Our best United Airlines deals on Buffalo to Panama City, Florida flight tickets
United Airlines
Sep 9
BUF6:00 amBuffalo
11h 38m
2 stops
ECP4:38 pmPanama City NW Florida Beaches
Sep 15
ECP6:30 amPanama City NW Florida Beaches
13h 37m
2 stops
BUF9:07 pmBuffalo
$375
United Airlines
Sep 7
BUF6:55 amBuffalo
7h 11m
1 stop
ECP1:06 pmPanama City NW Florida Beaches
Sep 15
ECP6:30 amPanama City NW Florida Beaches
13h 37m
2 stops
BUF9:07 pmBuffalo
$450
United Airlines
Jan 5
BUF7:00 amBuffalo
14h 06m
2 stops
ECP8:06 pmPanama City NW Florida Beaches
Jan 7
ECP10:25 amPanama City NW Florida Beaches
5h 22m
1 stop
BUF4:47 pmBuffalo
$451

momondo Fare Finder

 
Customize your flight search to find flights from Buffalo to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 16, 2026.
Use the filters below to find and compare flights from Buffalo to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Mon 2/1

12:58 pm-5:33 pm

1 stop5h 35m

Panama City NW Florida Beaches

Mon 2/8

6:03 pm-11:41 pm

1 stop4h 38m

$269
Quickest round-trip

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Sat 2/6

6:59 pm-10:47 pm

1 stop4h 48m

Panama City NW Florida Beaches

Sat 2/13

6:00 am-11:15 am

1 stop4h 15m

$269

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Wed 10/21

6:55 pm-11:18 pm

1 stop5h 23m

Panama City NW Florida Beaches

Mon 10/26

6:20 pm-11:59 pm

1 stop4h 39m

$293

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Fri 10/2

6:59 pm-11:25 pm

1 stop5h 26m

Panama City NW Florida Beaches

Mon 10/5

6:19 pm-11:52 pm

1 stop4h 33m

$306

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Mon 2/1

12:58 pm-5:33 pm

1 stop5h 35m

Panama City NW Florida Beaches

Mon 2/8

6:03 pm-11:41 pm

1 stop4h 38m

$325

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Wed 10/21

6:00 am-12:51 pm

1 stop7h 51m

Panama City NW Florida Beaches

Mon 10/26

7:15 am-3:06 pm

1 stop6h 51m

$325

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Sat 9/26

8:50 am-1:55 pm

1 stop6h 05m

Panama City NW Florida Beaches

Sat 10/10

5:55 am-2:35 pm

2 stops7h 40m

$360

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Sat 10/3

6:00 am-10:40 am

1 stop5h 40m

Panama City NW Florida Beaches

Sat 10/10

5:55 am-2:35 pm

2 stops7h 40m

$360

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Wed 9/9

6:00 am-4:38 pm

2 stops11h 38m

Panama City NW Florida Beaches

Tue 9/15

6:30 am-9:07 pm

2 stops13h 37m

$375

BuffaloPanama City

BUF Buffalo - ECP Panama City NW Florida Beaches

BUFECP

Buffalo

Tue 9/8

7:00 am-1:13 pm

1 stop7h 13m

Panama City NW Florida Beaches

Tue 9/15

6:30 am-9:07 pm

2 stops13h 37m

$450

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Buffalo to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from Buffalo is in August. Flight prices, which tend to average around $340, are often lower during this time because this is during the off-season. The month of January is another great option to travel to Panama City, Florida, with average flight prices from Buffalo averaging around $385.

Can stopping save me money on Buffalo to Panama City, Florida flights?

You could potentially save up to 70% on your flight if you consider stops on a Buffalo to Panama City, Florida flight.

When to book flights from Buffalo to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Buffalo to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Buffalo to Panama City, Florida (BUF to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Panama City, Florida

Fastest flight time

4h 55m

Direct flights

None
The fastest flight from Buffalo to Panama City, Florida takes 4h 55m
There are no direct flights from Buffalo to Panama City, Florida. There are no popular flight routes from Buffalo to Panama City, Florida.
Search flight deals

Frequently asked questions about flying from Buffalo to Panama City, Florida

  • How far is Buffalo to Panama City NW Florida Beaches by plane?

    A flight from Buffalo to Panama City NW Florida Beaches will travel around 955.1 mi. By plane, this route typically takes 4h 55m.

  • When did momondo last update prices for flights from Buffalo Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Buffalo Airport to Panama City NW Florida Beaches Airport were last updated today.

  • How many operators does momondo search for flights from Buffalo Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Buffalo Airport to Panama City NW Florida Beaches Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Buffalo Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The required travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City NW Florida Beaches Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Buffalo to Panama City, Florida?

Best airlines flying from Buffalo to Panama City, Florida

Compare and see reviews for airlines that fly from Buffalo to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $189Free CancellationRating
7.8
8,502 reviews
Search Delta flights
American AirlinesPriceFrom $304Free CancellationRating
7.1
11,947 reviews
Search American Airlines flights
SouthwestPriceFrom $361Free CancellationRating
8.0
4,217 reviews
Search Southwest flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to Panama City?

It is quick and easy to find Buffalo to Panama City flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama City that suits you.

Can I find flights from Buffalo to Panama City with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama City from Buffalo which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Buffalo to Panama City?

Once all potential Buffalo to Panama City flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Buffalo to Panama City right now. Can momondo alert me if prices change?

Price alerts on flights to Panama City from Buffalo are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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