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Cheap flights from Buffalo to Panama City from $149

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to Panama City departing on 10/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Buffalo to Panama City

Cheap round-trip flights

American Airlines Logo
6:42 pm - 10:53 pmBUF-ECP
5h 11m1 stop
American Airlines Logo
6:49 am - 3:31 pmECP-BUF
7h 42m2 stops
$328American Airlines
Find Deal
mar., oct. 7 - mar., oct. 14
American Airlines Logo
1:00 pm - 5:15 pmBUF-ECP
5h 15m1 stop
American Airlines Logo
5:50 pm - 11:26 pmECP-BUF
4h 36m1 stop
$342American Airlines
Find Deal
vie., nov. 7 - mar., nov. 11
American Airlines Logo
6:42 pm - 10:53 pmBUF-ECP
5h 11m1 stop
American Airlines Logo
6:49 am - 3:31 pmECP-BUF
7h 42m2 stops
$367American Airlines
Find Deal
mar., oct. 7 - mar., oct. 14
American Airlines Logo
6:07 am - 1:12 pmBUF-ECP
8h 05m2 stops
American Airlines Logo
6:49 am - 6:18 pmECP-BUF
10h 29m2 stops
$372American Airlines
Find Deal
mar., oct. 7 - mar., oct. 14
Delta Logo
6:25 pm - 10:57 pmBUF-ECP
5h 32m1 stop
Delta Logo
6:00 am - 11:04 amECP-BUF
4h 04m1 stop
$395Delta
Find Deal
lun., dic. 1 - lun., dic. 8
Delta Logo
7:30 pm - 11:10 pmBUF-ECP
4h 40m1 stop
Delta Logo
6:00 am - 5:00 pmECP-BUF
10h 00m2 stops
$423Delta
Find Deal
vie., nov. 7 - mar., nov. 11
United Airlines Logo
7:07 am - 1:10 pmBUF-ECP
7h 03m1 stop
United Airlines Logo
11:10 am - 10:42 pmECP-BUF
10h 32m2 stops
$452United Airlines
Find Deal
dom., sep. 28 - jue., oct. 2
United Airlines Logo
7:07 am - 1:10 pmBUF-ECP
7h 03m1 stop
United Airlines Logo
6:30 am - 6:13 pmECP-BUF
10h 43m2 stops
$456United Airlines
Find Deal
dom., sep. 28 - sáb., oct. 4
Southwest Logo
6:00 am - 12:55 pmBUF-ECP
7h 55m2 stops
Southwest Logo
1:30 pm - 11:40 pmECP-BUF
9h 10m2 stops
$473Southwest
Find Deal
vie., nov. 7 - jue., nov. 13
Southwest Logo
6:15 am - 12:50 pmBUF-ECP
7h 35m2 stops
Southwest Logo
7:10 pm - 7:50 amECP-BUF
11h 40m2 stops
$621Southwest
Find Deal
dom., oct. 19 - dom., oct. 26

American Airlines flights from Buffalo to Panama City, Florida

Our best American Airlines deals on Buffalo to Panama City, Florida flight tickets
American Airlines
Oct 7
BUF6:42 pmBuffalo
5h 11m
1 stop
ECP10:53 pmPanama City NW Florida Beaches
Oct 14
ECP6:49 amPanama City NW Florida Beaches
7h 42m
2 stops
BUF3:31 pmBuffalo
$328
Find similar
American Airlines
Nov 7
BUF1:00 pmBuffalo
5h 15m
1 stop
ECP5:15 pmPanama City NW Florida Beaches
Nov 11
ECP5:50 pmPanama City NW Florida Beaches
4h 36m
1 stop
BUF11:26 pmBuffalo
$342
Find similar
American Airlines
Oct 7
BUF6:42 pmBuffalo
5h 11m
1 stop
ECP10:53 pmPanama City NW Florida Beaches
Oct 14
ECP6:49 amPanama City NW Florida Beaches
7h 42m
2 stops
BUF3:31 pmBuffalo
$367
Find similar

Delta flights from Buffalo to Panama City, Florida

Our best Delta deals on Buffalo to Panama City, Florida flight tickets
Delta
Dec 1
BUF6:25 pmBuffalo
5h 32m
1 stop
ECP10:57 pmPanama City NW Florida Beaches
Dec 8
ECP6:00 amPanama City NW Florida Beaches
4h 04m
1 stop
BUF11:04 amBuffalo
$395
Find similar
Delta
Nov 7
BUF7:30 pmBuffalo
4h 40m
1 stop
ECP11:10 pmPanama City NW Florida Beaches
Nov 11
ECP6:00 amPanama City NW Florida Beaches
10h 00m
2 stops
BUF5:00 pmBuffalo
$423
Find similar
Delta
Oct 1
BUF7:08 pmBuffalo
4h 55m
1 stop
ECP11:03 pmPanama City NW Florida Beaches
Oct 5
ECP6:00 amPanama City NW Florida Beaches
4h 01m
1 stop
BUF11:01 amBuffalo
$427
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Buffalo to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated septiembre 15, 2025.
Use the filters below to find and compare flights from Buffalo to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

mar. 10/7

6:42 pm-10:53 pm

1 stop5h 11m

Panama City NW Florida Beaches

mar. 10/14

6:49 am-3:31 pm

2 stops7h 42m

$328

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

vie. 11/7

1:00 pm-5:15 pm

1 stop5h 15m

Panama City NW Florida Beaches

mar. 11/11

5:50 pm-11:26 pm

1 stop4h 36m

$342

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

mar. 10/7

6:42 pm-10:53 pm

1 stop5h 11m

Panama City NW Florida Beaches

mar. 10/14

6:49 am-3:31 pm

2 stops7h 42m

$367

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

mar. 10/7

6:07 am-1:12 pm

2 stops8h 05m

Panama City NW Florida Beaches

mar. 10/14

6:49 am-6:18 pm

2 stops10h 29m

$372

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

lun. 12/1

6:25 pm-10:57 pm

1 stop5h 32m

Panama City NW Florida Beaches

lun. 12/8

6:00 am-11:04 am

1 stop4h 04m

$395

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

vie. 11/7

7:30 pm-11:10 pm

1 stop4h 40m

Panama City NW Florida Beaches

mar. 11/11

6:00 am-5:00 pm

2 stops10h 00m

$423

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

dom. 9/28

7:07 am-1:10 pm

1 stop7h 03m

Panama City NW Florida Beaches

jue. 10/2

11:10 am-10:42 pm

2 stops10h 32m

$452

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

dom. 9/28

7:07 am-1:10 pm

1 stop7h 03m

Panama City NW Florida Beaches

sáb. 10/4

6:30 am-6:13 pm

2 stops10h 43m

$456

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

vie. 11/7

6:00 am-12:55 pm

2 stops7h 55m

Panama City NW Florida Beaches

jue. 11/13

1:30 pm-11:40 pm

2 stops9h 10m

$473

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

dom. 10/19

6:15 am-12:50 pm

2 stops7h 35m

Panama City NW Florida Beaches

dom. 10/26

7:10 pm-7:50 am

2 stops11h 40m

$621

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Buffalo to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from Buffalo is in February. Flight prices, which tend to average around $372, are often lower during this time because this is during the off-season. The month of July is another great option to travel to Panama City, Florida, with average flight prices from Buffalo averaging around $376.

What is the cheapest day to depart on your flight to Panama City, Florida?

Our data shows that Tuesday is the least expensive day to fly to Panama City, Florida. Tickets to fly out on this day can be as low as $356. On the other hand, Saturday is the most expensive day to depart from Buffalo because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $575.

How far in advance should I book a flight to Panama City, Florida?

You are more likely to see cheaper flights to Panama City, Florida from Buffalo when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City, Florida for around $442 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City, Florida from Buffalo for as low as $366 on momondo.

Can stopping save me money on Buffalo to Panama City, Florida flights?

You could potentially save up to 1% on your flight if you consider stops on a Buffalo to Panama City, Florida flight.

When to book flights from Buffalo to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Buffalo to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Buffalo to Panama City, Florida (BUF to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Panama City, Florida

Direct flights

None
There are no direct flights from Buffalo to Panama City, Florida. There are no popular flight routes from Buffalo to Panama City, Florida.
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  • How far is Buffalo to Panama City NW Florida Beaches by plane?

    A flight from Buffalo to Panama City NW Florida Beaches will travel around 955.1 mi. By plane, this route typically takes 4h 40m.

  • When did momondo last update prices for flights from Buffalo Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Buffalo Airport to Panama City NW Florida Beaches Airport were last updated today.

  • How many operators does momondo search for flights from Buffalo Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Buffalo Airport to Panama City NW Florida Beaches Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Buffalo Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The required travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City NW Florida Beaches Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Buffalo to Panama City, Florida?

Best airlines flying from Buffalo to Panama City, Florida

Compare and see reviews for airlines that fly from Buffalo to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $286Free CancellationRating
7.9
7,954 reviews
Search Delta flights
American AirlinesPriceFrom $347Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
SouthwestPriceFrom $396Free CancellationRating
8.0
4,242 reviews
Search Southwest flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to Panama City?

It is quick and easy to find Buffalo to Panama City flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama City that suits you.

Can I find flights from Buffalo to Panama City with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama City from Buffalo which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Buffalo to Panama City?

Once all potential Buffalo to Panama City flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Buffalo to Panama City right now. Can momondo alert me if prices change?

Price alerts on flights to Panama City from Buffalo are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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