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Cheap flights from Buffalo to Panama City from $160

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Buffalo to Panama City departing on 2/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:00 am - 12:10 pm
BUF
-
ECP
7h 10m1 stop
Delta Logo
5:14 pm - 11:56 pm
ECP
-
BUF
5h 42m1 stop
$269Delta
Sat, Jan 17 - Sat, Jan 17
Delta Logo
2:10 pm - 7:50 pm
BUF
-
ECP
6h 40m1 stop
Delta Logo
5:14 pm - 11:56 pm
ECP
-
BUF
5h 42m1 stop
$294Delta
Wed, Jan 14 - Sat, Jan 17
Delta Logo
3:38 pm - 10:51 pm
BUF
-
ECP
8h 13m2 stops
Delta Logo
7:20 am - 1:14 pm
ECP
-
BUF
4h 54m1 stop
$299Delta
Wed, Jan 14 - Sat, Jan 17
American Airlines Logo
12:58 pm - 5:33 pm
BUF
-
ECP
5h 35m1 stop
American Airlines Logo
12:03 pm - 6:13 pm
ECP
-
BUF
5h 10m1 stop
$319American Airlines
Fri, Jan 30 - Thu, Feb 5
American Airlines Logo
7:00 am - 11:33 am
BUF
-
ECP
5h 33m1 stop
American Airlines Logo
1:34 pm - 10:40 pm
ECP
-
BUF
8h 06m2 stops
$324American Airlines
Fri, Jan 30 - Thu, Feb 5
Southwest Logo
1:20 pm - 6:10 pm
BUF
-
ECP
5h 50m1 stop
Southwest Logo
7:35 am - 1:55 pm
ECP
-
BUF
5h 20m1 stop
$327Southwest
Wed, Feb 4 - Mon, Feb 9
American Airlines Logo
5:12 am - 11:33 am
BUF
-
ECP
7h 21m2 stops
American Airlines Logo
1:34 pm - 10:40 pm
ECP
-
BUF
8h 06m2 stops
$329American Airlines
Fri, Jan 30 - Thu, Feb 5
Delta Logo
6:00 am - 12:10 pm
BUF
-
ECP
7h 10m1 stop
Delta Logo
6:09 pm - 11:28 pm
ECP
-
BUF
4h 19m1 stop
$353Delta
Fri, Jan 30 - Thu, Feb 5
American Airlines Logo
12:58 pm - 5:33 pm
BUF
-
ECP
5h 35m1 stop
American Airlines Logo
1:34 pm - 10:40 pm
ECP
-
BUF
8h 06m2 stops
$358American Airlines
Wed, Jan 21 - Sun, Jan 25
Southwest Logo
1:20 pm - 6:10 pm
BUF
-
ECP
5h 50m1 stop
Southwest Logo
7:35 am - 2:05 pm
ECP
-
BUF
5h 30m1 stop
$363Southwest
Wed, Jan 21 - Sun, Jan 25

Delta flights from Buffalo to Panama City, Florida

Our best Delta deals on Buffalo to Panama City, Florida flight tickets
Delta
Jan 17
BUF6:00 amBuffalo
7h 10m
1 stop
ECP12:10 pmPanama City NW Florida Beaches
Jan 17
ECP5:14 pmPanama City NW Florida Beaches
5h 42m
1 stop
BUF11:56 pmBuffalo
$269
Find similar
Delta
Jan 14
BUF2:10 pmBuffalo
6h 40m
1 stop
ECP7:50 pmPanama City NW Florida Beaches
Jan 17
ECP5:14 pmPanama City NW Florida Beaches
5h 42m
1 stop
BUF11:56 pmBuffalo
$294
Find similar
Delta
Jan 14
BUF3:38 pmBuffalo
8h 13m
2 stops
ECP10:51 pmPanama City NW Florida Beaches
Jan 17
ECP7:20 amPanama City NW Florida Beaches
4h 54m
1 stop
BUF1:14 pmBuffalo
$299
Find similar

American Airlines flights from Buffalo to Panama City, Florida

Our best American Airlines deals on Buffalo to Panama City, Florida flight tickets
American Airlines
Jan 30
BUF12:58 pmBuffalo
5h 35m
1 stop
ECP5:33 pmPanama City NW Florida Beaches
Feb 5
ECP12:03 pmPanama City NW Florida Beaches
5h 10m
1 stop
BUF6:13 pmBuffalo
$319
Find similar
American Airlines
Jan 30
BUF7:00 amBuffalo
5h 33m
1 stop
ECP11:33 amPanama City NW Florida Beaches
Feb 5
ECP1:34 pmPanama City NW Florida Beaches
8h 06m
2 stops
BUF10:40 pmBuffalo
$324
Find similar
American Airlines
Jan 30
BUF5:12 amBuffalo
7h 21m
2 stops
ECP11:33 amPanama City NW Florida Beaches
Feb 5
ECP1:34 pmPanama City NW Florida Beaches
8h 06m
2 stops
BUF10:40 pmBuffalo
$329
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Buffalo to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 21, 2025.
Use the filters below to find and compare flights from Buffalo to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Sat 1/17

6:00 am-12:10 pm

1 stop7h 10m

Panama City NW Florida Beaches

Sat 1/17

5:14 pm-11:56 pm

1 stop5h 42m

$269

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Wed 1/14

2:10 pm-7:50 pm

1 stop6h 40m

Panama City NW Florida Beaches

Sat 1/17

5:14 pm-11:56 pm

1 stop5h 42m

$294

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Wed 1/14

3:38 pm-10:51 pm

2 stops8h 13m

Panama City NW Florida Beaches

Sat 1/17

7:20 am-1:14 pm

1 stop4h 54m

$299

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Fri 1/30

12:58 pm-5:33 pm

1 stop5h 35m

Panama City NW Florida Beaches

Thu 2/5

12:03 pm-6:13 pm

1 stop5h 10m

$319

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Fri 1/30

7:00 am-11:33 am

1 stop5h 33m

Panama City NW Florida Beaches

Thu 2/5

1:34 pm-10:40 pm

2 stops8h 06m

$324

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Wed 2/4

1:20 pm-6:10 pm

1 stop5h 50m

Panama City NW Florida Beaches

Mon 2/9

7:35 am-1:55 pm

1 stop5h 20m

$327

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Fri 1/30

5:12 am-11:33 am

2 stops7h 21m

Panama City NW Florida Beaches

Thu 2/5

1:34 pm-10:40 pm

2 stops8h 06m

$329

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Fri 1/30

6:00 am-12:10 pm

1 stop7h 10m

Panama City NW Florida Beaches

Thu 2/5

6:09 pm-11:28 pm

1 stop4h 19m

$353

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Wed 1/21

12:58 pm-5:33 pm

1 stop5h 35m

Panama City NW Florida Beaches

Sun 1/25

1:34 pm-10:40 pm

2 stops8h 06m

$358

BuffaloPanama City

BUF - ECP

BUFECP

Buffalo

Wed 1/21

1:20 pm-6:10 pm

1 stop5h 50m

Panama City NW Florida Beaches

Sun 1/25

7:35 am-2:05 pm

1 stop5h 30m

$363

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Buffalo to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Buffalo and Panama City, Florida?

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from Buffalo is in November. Flight prices, which tend to average around $349, are often lower during this time because this is during the off-season. The month of February is another great option to travel to Panama City, Florida, with average flight prices from Buffalo averaging around $372.

What is the cheapest day to depart on your flight to Panama City, Florida?

Our data shows that Tuesday is the least expensive day to fly to Panama City, Florida. Tickets to fly out on this day can be as low as $356. On the other hand, Saturday is the most expensive day to depart from Buffalo because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $575.

How far in advance should I book a flight to Panama City, Florida?

You are more likely to see cheaper flights to Panama City, Florida from Buffalo when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City, Florida for around $432 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City, Florida from Buffalo for as low as $391 on momondo.

Can stopping save me money on Buffalo to Panama City, Florida flights?

You could potentially save up to 48% on your flight if you consider stops on a Buffalo to Panama City, Florida flight.

When to book flights from Buffalo to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Buffalo to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Buffalo to Panama City, Florida (BUF to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Buffalo to Panama City, Florida

Fastest flight time

4h 25m

Direct flights

None
The fastest flight from Buffalo to Panama City, Florida takes 4h 25m
There are no direct flights from Buffalo to Panama City, Florida. There are no popular flight routes from Buffalo to Panama City, Florida.
Search flight deals

  • How far is Buffalo to Panama City NW Florida Beaches by plane?

    A flight from Buffalo to Panama City NW Florida Beaches will travel around 955.1 mi. By plane, this route typically takes 4h 25m.

  • When did momondo last update prices for flights from Buffalo Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Buffalo Airport to Panama City NW Florida Beaches Airport were last updated today.

  • How many operators does momondo search for flights from Buffalo Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Buffalo Airport to Panama City NW Florida Beaches Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Buffalo Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The required travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City NW Florida Beaches Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Buffalo to Panama City, Florida?

Best airlines flying from Buffalo to Panama City, Florida

Compare and see reviews for airlines that fly from Buffalo to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $270Free CancellationRating
7.9
8,014 reviews
Search Delta flights
American AirlinesPriceFrom $292Free CancellationRating
7.2
11,051 reviews
Search American Airlines flights
SouthwestPriceFrom $381Free CancellationRating
8.0
4,254 reviews
Search Southwest flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from Buffalo to Panama City?

It is quick and easy to find Buffalo to Panama City flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama City that suits you.

Can I find flights from Buffalo to Panama City with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama City from Buffalo which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Buffalo to Panama City?

Once all potential Buffalo to Panama City flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Buffalo to Panama City right now. Can momondo alert me if prices change?

Price alerts on flights to Panama City from Buffalo are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Panama City, Florida trip

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