Cheap flights from St. Louis to Pittsburgh from $121

In general, December is the cheapest month to fly from St. Louis to Pittsburgh. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $263. The month of November is another great option to travel to Pittsburgh, with average flight prices from St. Louis averaging around $282.

The cheapest day to depart on your flight to Pittsburgh is on a Wednesday when prices can be found for as low as $288. This is often the case because there is less demand to fly during this day of the week. Flights from St. Louis to Pittsburgh on a Sunday will generally be more expensive and average around $554. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

Our data shows that the cheapest St. Louis to Pittsburgh flights are usually those with departure times in the afternoon. Our users have found flights to Pittsburgh in the afternoon for as low as $289. Flights to Pittsburgh are more costly in the evening, with an average ticket price of $404. Departure times in the evening fall within the peak daily travel times, which is why tickets can be more expensive.

Fly from Lambert-St Louis to Pittsburgh for the best Lambert-St Louis - Pittsburgh flight prices

There is only 1 cabin class available to choose from on St. Louis to Pittsburgh flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 24% on your flight if you consider stops on a St. Louis to Pittsburgh flight.

Southwest and United Airlines are the most popular carriers operating from Lambert-St Louis to Pittsburgh

Southwest, American Airlines and United Airlines are the top three most popular airlines that fly to Pittsburgh from St. Louis according to our data. Southwest is the first choice among our users, with 79% of people opting to fly with this airline when traveling to Pittsburgh. Keep in mind that there are 4 different airlines that fly to Pittsburgh on a routine basis, so you have a few additional options to choose from.

Chicago (ORD) was the most common stop: 60% of momondo users choosing 1-stop flights on this route connected there.

Flights via Chicago (ORD) offer the lowest average round-trip price of $279.

Flights connecting via Chicago (MDW) have the shortest average one-way travel time: 3h 15m.

Nashville (BNA) has the shortest average layover time for this route: 0h 48m.

As of October 2026, 1 flights take off from St. Louis and land in Pittsburgh each day. The most common flight departure time for this route is 10:00AM, with 66% of daily flights taking off at noon.

The number of flights available between St. Louis and Pittsburgh is 10 per week as of October 2026. The most frequent departure day is Mon, with 20% of weekly flights leaving on this day.