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Cheap flights from St. Louis to Panama City from $104

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Panama City departing on 12/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

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Delta Logo
6:00 am - 12:47 pmSTL-ECP
6h 47m1 stop
Delta Logo
6:00 am - 10:45 amECP-STL
4h 45m1 stop
$207Delta
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Thu, Dec 4 - Thu, Dec 11
Southwest Logo
10:15 am - 3:50 pmSTL-ECP
5h 35m1 stop
Southwest Logo
10:00 am - 5:25 pmECP-STL
7h 25m2 stops
$212Southwest
Find Deal
Thu, Dec 4 - Thu, Dec 11
Southwest Logo
5:45 am - 2:40 pmSTL-ECP
8h 55m2 stops
Southwest Logo
10:00 am - 5:25 pmECP-STL
7h 25m2 stops
$272Southwest
Find Deal
Thu, Dec 4 - Thu, Dec 11
United Airlines Logo
6:00 am - 12:02 pmSTL-ECP
6h 02m1 stop
United Airlines Logo
4:54 pm - 10:00 pmECP-STL
5h 06m1 stop
$289United Airlines
Find Deal
Tue, Jan 20 - Sun, Jan 25
United Airlines Logo
6:30 am - 4:12 pmSTL-ECP
9h 42m2 stops
United Airlines Logo
4:54 pm - 10:00 pmECP-STL
5h 06m1 stop
$294United Airlines
Find Deal
Tue, Jan 20 - Sun, Jan 25
American Airlines Logo
9:33 am - 5:33 pmSTL-ECP
8h 00m2 stops
American Airlines Logo
12:03 pm - 9:51 pmECP-STL
9h 48m2 stops
$299American Airlines
Find Deal
Tue, Jan 20 - Sun, Jan 25
Delta Logo
10:13 am - 1:27 pmSTL-ECP
3h 14m1 stop
Delta Logo
8:03 am - 2:49 pmECP-STL
6h 46m1 stop
$309Delta
Find Deal
Tue, Mar 3 - Wed, Mar 4
American Airlines Logo
7:00 am - 5:33 pmSTL-ECP
10h 33m2 stops
American Airlines Logo
6:03 pm - 10:21 amECP-STL
16h 18m2 stops
$312American Airlines
Find Deal
Thu, Feb 5 - Mon, Feb 9
United Airlines Logo
8:20 am - 4:03 pmSTL-ECP
7h 43m1 stop
United Airlines Logo
5:00 pm - 9:58 pmECP-STL
4h 58m1 stop
$314United Airlines
Find Deal
Tue, Nov 25 - Wed, Dec 10
American Airlines Logo
9:33 am - 5:33 pmSTL-ECP
8h 00m2 stops
American Airlines Logo
12:03 pm - 9:51 pmECP-STL
9h 48m2 stops
$324American Airlines
Find Deal
Sun, Jan 18 - Mon, Jan 26

American Airlines flights from St. Louis to Panama City, Florida

Our best American Airlines deals on St. Louis to Panama City, Florida flight tickets
American Airlines
Jan 20
STL9:33 amLambert-St Louis
8h 00m
2 stops
ECP5:33 pmPanama City NW Florida Beaches
Jan 25
ECP12:03 pmPanama City NW Florida Beaches
9h 48m
2 stops
STL9:51 pmLambert-St Louis
$299
Find similar
American Airlines
Feb 5
STL7:00 amLambert-St Louis
10h 33m
2 stops
ECP5:33 pmPanama City NW Florida Beaches
Feb 9
ECP6:03 pmPanama City NW Florida Beaches
16h 18m
2 stops
STL10:21 amLambert-St Louis
$312
Find similar
American Airlines
Jan 18
STL9:33 amLambert-St Louis
8h 00m
2 stops
ECP5:33 pmPanama City NW Florida Beaches
Jan 26
ECP12:03 pmPanama City NW Florida Beaches
9h 48m
2 stops
STL9:51 pmLambert-St Louis
$324
Find similar

Delta flights from St. Louis to Panama City, Florida

Our best Delta deals on St. Louis to Panama City, Florida flight tickets
Delta
Dec 4
STL6:00 amLambert-St Louis
6h 47m
1 stop
ECP12:47 pmPanama City NW Florida Beaches
Dec 11
ECP6:00 amPanama City NW Florida Beaches
4h 45m
1 stop
STL10:45 amLambert-St Louis
$207
Find similar
Delta
Mar 3
STL10:13 amLambert-St Louis
3h 14m
1 stop
ECP1:27 pmPanama City NW Florida Beaches
Mar 4
ECP8:03 amPanama City NW Florida Beaches
6h 46m
1 stop
STL2:49 pmLambert-St Louis
$309
Find similar
Delta
Nov 16
STL9:33 amLambert-St Louis
3h 14m
1 stop
ECP12:47 pmPanama City NW Florida Beaches
Nov 20
ECP9:23 amPanama City NW Florida Beaches
6h 44m
1 stop
STL4:07 pmLambert-St Louis
$338
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from St. Louis to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Thu 12/4

6:00 am-12:47 pm

1 stop6h 47m

Panama City NW Florida Beaches

Thu 12/11

6:00 am-10:45 am

1 stop4h 45m

$207

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Thu 12/4

10:15 am-3:50 pm

1 stop5h 35m

Panama City NW Florida Beaches

Thu 12/11

10:00 am-5:25 pm

2 stops7h 25m

$212

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Thu 12/4

5:45 am-2:40 pm

2 stops8h 55m

Panama City NW Florida Beaches

Thu 12/11

10:00 am-5:25 pm

2 stops7h 25m

$272

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Tue 1/20

6:00 am-12:02 pm

1 stop6h 02m

Panama City NW Florida Beaches

Sun 1/25

4:54 pm-10:00 pm

1 stop5h 06m

$289

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Tue 1/20

6:30 am-4:12 pm

2 stops9h 42m

Panama City NW Florida Beaches

Sun 1/25

4:54 pm-10:00 pm

1 stop5h 06m

$294

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Tue 1/20

9:33 am-5:33 pm

2 stops8h 00m

Panama City NW Florida Beaches

Sun 1/25

12:03 pm-9:51 pm

2 stops9h 48m

$299

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Tue 3/3

10:13 am-1:27 pm

1 stop3h 14m

Panama City NW Florida Beaches

Wed 3/4

8:03 am-2:49 pm

1 stop6h 46m

$309

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Thu 2/5

7:00 am-5:33 pm

2 stops10h 33m

Panama City NW Florida Beaches

Mon 2/9

6:03 pm-10:21 am

2 stops16h 18m

$312

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Tue 11/25

8:20 am-4:03 pm

1 stop7h 43m

Panama City NW Florida Beaches

Wed 12/10

5:00 pm-9:58 pm

1 stop4h 58m

$314

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sun 1/18

9:33 am-5:33 pm

2 stops8h 00m

Panama City NW Florida Beaches

Mon 1/26

12:03 pm-9:51 pm

2 stops9h 48m

$324

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from St. Louis to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from St. Louis is in October. Flight prices, which tend to average around $296, are often lower during this time because this is during the off-season. The month of September is another great option to travel to Panama City, Florida, with average flight prices from St. Louis averaging around $334.

What is the cheapest day to depart on your flight to Panama City, Florida?

Our data shows that Wednesday is the least expensive day to fly to Panama City, Florida. Tickets to fly out on this day can be as low as $353. On the other hand, Saturday is the most expensive day to depart from St. Louis because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $457.

What is the cheapest Lambert-St Louis to Panama City NW Florida Beaches flight route?

Fly from Lambert-St Louis to Panama City NW Florida Beaches for the best Lambert-St Louis - Panama City NW Florida Beaches flight prices

How far in advance should I book a flight to Panama City, Florida?

You are more likely to see cheaper flights to Panama City, Florida from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City, Florida for around $404 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City, Florida from St. Louis for as low as $300 on momondo.

What cabin class options are available on Lambert-St Louis to Panama City NW Florida Beaches flights?

There is only 1 cabin class available to choose from on Lambert-St Louis to Panama City NW Florida Beaches flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have St. Louis to Panama City, Florida flight prices changed over time?

As of November 2025, prices for St. Louis to Panama City, Florida flights are approximately 57% cheaper when compared to flights at the same time last year.

When to book flights from St. Louis to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Panama City, Florida (STL to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Panama City, Florida

Fastest flight time

1h 45m

Direct flights

Every day

Airports in Panama City, Florida

1 airport
The fastest flight from St. Louis to Panama City, Florida takes 1h 45m
Direct flights go from St. Louis to Panama City, Florida every day.
There is 1 airport near Panama City, Florida: Panama City NW Florida Beaches (ECP)
Search flight deals

  • How far is Lambert-St Louis to Panama City NW Florida Beaches by plane?

    The straight-line distance from Lambert-St Louis to Panama City NW Florida Beaches is 639.0 mi. 1h 45m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The necessary travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from St. Louis to Panama City, Florida?

  • What is the most popular airline from St. Louis to Panama City, Florida?

Best airlines flying from St. Louis to Panama City, Florida

Compare and see reviews for airlines that fly from St. Louis to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $186Free CancellationRating
7.9
8,002 reviews
Search Delta flights
American AirlinesPriceFrom $212Free CancellationRating
7.2
11,038 reviews
Search American Airlines flights
SouthwestPriceFrom $228Free CancellationRating
8.0
4,238 reviews
Search Southwest flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Panama City with flexible booking policies on momondo?

Flights from St. Louis to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from St. Louis to Panama City.

I’m not ready to book a flight from St. Louis to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for St. Louis to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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