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Cheap flights from St. Louis to Panama City from $109

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from St. Louis to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
2:50 pm - 4:35 pmSTL  Lambert-St Louis-ECP Panama City NW Florida Beaches
1h 45mnonstop
Southwest Logo
5:10 pm - 6:55 pmECP  Panama City NW Florida Beaches-STL Lambert-St Louis
1h 45mnonstop
$217Southwest
Mon, Sep 21 - Mon, Sep 28
Southwest Logo
12:20 pm - 2:05 pmSTL  Lambert-St Louis-ECP Panama City NW Florida Beaches
1h 45mnonstop
Southwest Logo
3:45 pm - 5:35 pmECP  Panama City NW Florida Beaches-STL Lambert-St Louis
1h 50mnonstop
$217Southwest
Sat, Sep 19 - Tue, Sep 22
Southwest Logo
1:55 pm - 3:40 pmSTL  Lambert-St Louis-ECP Panama City NW Florida Beaches
1h 45mnonstop
Southwest Logo
5:10 pm - 6:55 pmECP  Panama City NW Florida Beaches-STL Lambert-St Louis
1h 45mnonstop
$217Southwest
Tue, Sep 22 - Thu, Sep 24
Delta Logo
10:14 am - 4:37 pmSTL  Lambert-St Louis-ECP Panama City NW Florida Beaches
6h 23m1 stop Atlanta Hartsfield-Jackson
Delta Logo
11:21 am - 4:28 pmECP  Panama City NW Florida Beaches-STL Lambert-St Louis
5h 07m1 stop Atlanta Hartsfield-Jackson
$227Delta
Wed, Oct 28 - Mon, Nov 2
Delta Logo
5:46 pm - 11:05 pmSTL  Lambert-St Louis-ECP Panama City NW Florida Beaches
5h 19m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:12 am - 10:51 amECP  Panama City NW Florida Beaches-STL Lambert-St Louis
3h 39m1 stop Atlanta Hartsfield-Jackson
$227Delta
Sat, Oct 3 - Sat, Oct 10
American Airlines Logo
4:21 pm - 11:53 pmSTL  Lambert-St Louis-ECP Panama City NW Florida Beaches
7h 32m1 stop Charlotte Douglas
American Airlines Logo
6:42 pm - 11:59 pmECP  Panama City NW Florida Beaches-STL Lambert-St Louis
5h 17m1 stop Charlotte Douglas
$227American Airlines
Sat, Oct 17 - Sat, Oct 24
American Airlines Logo
4:21 pm - 11:53 pmSTL  Lambert-St Louis-ECP Panama City NW Florida Beaches
7h 32m1 stop Charlotte Douglas
American Airlines Logo
6:42 pm - 11:59 pmECP  Panama City NW Florida Beaches-STL Lambert-St Louis
5h 17m1 stop Charlotte Douglas
$268American Airlines
Sat, Oct 17 - Fri, Oct 23
United Airlines Logo
1:08 pm - 9:36 pmSTL  Lambert-St Louis-ECP Panama City NW Florida Beaches
8h 28m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
United Airlines Logo
4:55 pm - 10:26 pmECP  Panama City NW Florida Beaches-STL Lambert-St Louis
5h 31m1 stop Houston George Bush Intcntl
$268United Airlines
Fri, Nov 13 - Tue, Nov 17
American Airlines Logo
11:09 am - 6:31 pmSTL  Lambert-St Louis-ECP Panama City NW Florida Beaches
7h 22m1 stop Charlotte Douglas
American Airlines Logo
7:01 pm - 11:58 pmECP  Panama City NW Florida Beaches-STL Lambert-St Louis
4h 57m1 stop Charlotte Douglas
$304American Airlines
Fri, Jan 1 - Tue, Jan 5
United Airlines Logo
11:35 am - 10:18 pmSTL  Lambert-St Louis-ECP Panama City NW Florida Beaches
10h 43m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
United Airlines Logo
4:16 pm - 9:21 pmECP  Panama City NW Florida Beaches-STL Lambert-St Louis
5h 05m1 stop Chicago O'Hare Intl
$307United Airlines
Sat, Oct 3 - Sat, Oct 10

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Delta flights from St. Louis to Panama City, Florida

Our best Delta deals on St. Louis to Panama City, Florida flight tickets
Delta
Sep 22
STL7:05 amLambert-St Louis
5h 34m
1 stop
ECP12:39 pmPanama City NW Florida Beaches
Sep 24
ECP1:46 pmPanama City NW Florida Beaches
6h 12m
1 stop
STL7:58 pmLambert-St Louis
$227
Delta
Sep 26
STL5:46 pmLambert-St Louis
5h 19m
1 stop
ECP11:05 pmPanama City NW Florida Beaches
Sep 29
ECP7:35 amPanama City NW Florida Beaches
5h 48m
1 stop
STL1:23 pmLambert-St Louis
$237
Delta
Oct 2
STL4:59 pmLambert-St Louis
6h 26m
1 stop
ECP11:25 pmPanama City NW Florida Beaches
Oct 6
ECP6:00 amPanama City NW Florida Beaches
4h 51m
1 stop
STL10:51 amLambert-St Louis
$263

Southwest flights from St. Louis to Panama City, Florida

Our best Southwest deals on St. Louis to Panama City, Florida flight tickets
Southwest
Sep 19
STL12:20 pmLambert-St Louis
1h 45m
ECP2:05 pmPanama City NW Florida Beaches
Sep 22
ECP3:45 pmPanama City NW Florida Beaches
1h 50m
STL5:35 pmLambert-St Louis
$217
Southwest
Sep 21
STL5:45 amLambert-St Louis
5h 00m
1 stop
ECP10:45 amPanama City NW Florida Beaches
Sep 28
ECP5:10 pmPanama City NW Florida Beaches
1h 45m
STL6:55 pmLambert-St Louis
$222
Southwest
Oct 3
STL8:55 amLambert-St Louis
10h 55m
1 stop
ECP7:50 pmPanama City NW Florida Beaches
Oct 10
ECP5:55 amPanama City NW Florida Beaches
1h 50m
STL7:45 amLambert-St Louis
$228

momondo Fare Finder

 
Use the filters below to find and compare flights from St. Louis to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

St. LouisPanama City

STL Lambert-St Louis - ECP Panama City NW Florida Beaches

STLECP

Lambert-St Louis

Mon 9/21

2:50 pm-4:35 pm

Nonstop1h 45m

Panama City NW Florida Beaches

Mon 9/28

5:10 pm-6:55 pm

Nonstop1h 45m

$217

St. LouisPanama City

STL Lambert-St Louis - ECP Panama City NW Florida Beaches

STLECP

Lambert-St Louis

Sat 9/19

12:20 pm-2:05 pm

Nonstop1h 45m

Panama City NW Florida Beaches

Tue 9/22

3:45 pm-5:35 pm

Nonstop1h 50m

$217

St. LouisPanama City

STL Lambert-St Louis - ECP Panama City NW Florida Beaches

STLECP

Lambert-St Louis

Tue 9/22

1:55 pm-3:40 pm

Nonstop1h 45m

Panama City NW Florida Beaches

Thu 9/24

5:10 pm-6:55 pm

Nonstop1h 45m

$217

St. LouisPanama City

STL Lambert-St Louis - ECP Panama City NW Florida Beaches

STLECP

Lambert-St Louis

Wed 10/28

10:14 am-4:37 pm

1 stop6h 23m

Panama City NW Florida Beaches

Mon 11/2

11:21 am-4:28 pm

1 stop5h 07m

$227

St. LouisPanama City

STL Lambert-St Louis - ECP Panama City NW Florida Beaches

STLECP

Lambert-St Louis

Sat 10/3

5:46 pm-11:05 pm

1 stop5h 19m

Panama City NW Florida Beaches

Sat 10/10

7:12 am-10:51 am

1 stop3h 39m

$227

St. LouisPanama City

STL Lambert-St Louis - ECP Panama City NW Florida Beaches

STLECP

Lambert-St Louis

Sat 10/17

4:21 pm-11:53 pm

1 stop7h 32m

Panama City NW Florida Beaches

Sat 10/24

6:42 pm-11:59 pm

1 stop5h 17m

$227

St. LouisPanama City

STL Lambert-St Louis - ECP Panama City NW Florida Beaches

STLECP

Lambert-St Louis

Sat 10/17

4:21 pm-11:53 pm

1 stop7h 32m

Panama City NW Florida Beaches

Fri 10/23

6:42 pm-11:59 pm

1 stop5h 17m

$268

St. LouisPanama City

STL Lambert-St Louis - ECP Panama City NW Florida Beaches

STLECP

Lambert-St Louis

Fri 11/13

1:08 pm-9:36 pm

2 stops8h 28m

Panama City NW Florida Beaches

Tue 11/17

4:55 pm-10:26 pm

1 stop5h 31m

$268

St. LouisPanama City

STL Lambert-St Louis - ECP Panama City NW Florida Beaches

STLECP

Lambert-St Louis

Fri 1/1

11:09 am-6:31 pm

1 stop7h 22m

Panama City NW Florida Beaches

Tue 1/5

7:01 pm-11:58 pm

1 stop4h 57m

$304

St. LouisPanama City

STL Lambert-St Louis - ECP Panama City NW Florida Beaches

STLECP

Lambert-St Louis

Sat 10/3

11:35 am-10:18 pm

2 stops10h 43m

Panama City NW Florida Beaches

Sat 10/10

4:16 pm-9:21 pm

1 stop5h 05m

$307

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from St. Louis to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between St. Louis and Panama City, Florida?

Prices are currently low for flights on this route.

Typical prices usually range from $284 to $464.
The lowest price recently found on this route was $217.

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from St. Louis is in December. Flight prices, which tend to average around $302, are often lower during this time because this is during the off-season. The month of October is another great option to travel to Panama City, Florida, with average flight prices from St. Louis averaging around $332.

What is the cheapest day to depart on your flight to Panama City, Florida?

Our data shows that Tuesday is the least expensive day to fly to Panama City, Florida. Tickets to fly out on this day can be as low as $362. On the other hand, Sunday is the most expensive day to depart from St. Louis because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $549.

What is the cheapest Lambert-St Louis to Panama City NW Florida Beaches flight route?

Fly from Lambert-St Louis to Panama City NW Florida Beaches for the best Lambert-St Louis - Panama City NW Florida Beaches flight prices

How far in advance should I book a flight from St. Louis to Panama City, Florida?

You are more likely to see cheaper flights to Panama City, Florida from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City, Florida for around $375 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City, Florida from St. Louis for as low as $338 on momondo.

What cabin class options are available on St. Louis to Panama City, Florida flights?

There is only 1 cabin class available to choose from on St. Louis to Panama City, Florida flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on St. Louis to Panama City, Florida flights?

You could potentially save up to 49% on your flight if you consider stops on a St. Louis to Panama City, Florida flight.

How have St. Louis to Panama City, Florida flight prices changed over time?

As of August 2026, prices for St. Louis to Panama City, Florida flights are approximately 4% more expensive when compared to flights at the same time last year.

When to book flights from St. Louis to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Panama City, Florida (STL to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Panama City, Florida

Best Price Found

$109

Fastest flight time

1h 45m

Direct flights

Every day

Airports in Panama City, Florida

1 airport
The best one-way flight to Panama City, Florida from St. Louis in the past 72 hours is $109. The best round-trip flight deal from St. Louis to Panama City, Florida found on momondo in the last 72 hours is $217.
The fastest flight from St. Louis to Panama City, Florida takes 1h 45m
Direct flights go from St. Louis to Panama City, Florida every day.
There is 1 airport in Panama City, Florida. From St. Louis there are direct flights to Panama City NW Florida Beaches (ECP).
Search flight deals

Frequently asked questions about flying from St. Louis to Panama City, Florida

  • How far is Lambert-St Louis to Panama City NW Florida Beaches by plane?

    The straight-line distance from Lambert-St Louis to Panama City NW Florida Beaches is 639.0 mi. 1h 45m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The necessary travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from St. Louis to Panama City, Florida?

  • What is the most popular airline from St. Louis to Panama City, Florida?

Best airlines flying from St. Louis to Panama City, Florida

Compare and see reviews for airlines that fly from St. Louis to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $176Free CancellationRating
7.8
8,518 reviews
Search Delta flights
American AirlinesPriceFrom $226Free CancellationRating
7.1
11,988 reviews
Search American Airlines flights
SouthwestPriceFrom $242Free CancellationRating
8.0
4,214 reviews
Search Southwest flights

  • Southwest Flights From St. Louis to Panama City, Florida

    The lowest priced Southwest flight from St. Louis to Panama City, Florida from the last 72 hours was $242. Generally, Southwest has 6 flights on this route every week with an average price of $427. Southwest is rated 8.0/10 by our users.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Panama City with flexible booking policies on momondo?

Flights from St. Louis to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from St. Louis to Panama City.

I’m not ready to book a flight from St. Louis to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for St. Louis to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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