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Cheap flights from St. Louis to Panama City from $122

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Panama City departing on 9/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from St. Louis to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:23 pm - 9:40 pm
STL
-
ECP
4h 17m
1 stop
Delta Logo
6:00 am - 9:54 am
ECP
-
STL
3h 54m
1 stop
$307Delta
Tue, Aug 4 - Wed, Aug 12
Southwest Logo
3:40 pm - 5:25 pm
STL
-
ECP
1h 45mnonstop
Southwest Logo
5:55 am - 7:45 am
ECP
-
STL
1h 50mnonstop
$318Southwest
Mon, Oct 5 - Sat, Oct 10
Southwest Logo
8:35 am - 3:00 pm
STL
-
ECP
6h 25m
2 stops
Southwest Logo
4:20 pm - 10:10 pm
ECP
-
STL
5h 50m
1 stop
$322Southwest
Tue, Aug 4 - Wed, Aug 12
Southwest Logo
12:45 pm - 8:30 pm
STL
-
ECP
7h 45m
2 stops
Southwest Logo
11:30 am - 7:55 pm
ECP
-
STL
8h 25m
2 stops
$327Southwest
Tue, Aug 4 - Wed, Aug 12
Delta Logo
1:04 pm - 6:35 pm
STL
-
ECP
5h 31m
1 stop
Delta Logo
6:00 am - 11:46 am
ECP
-
STL
5h 46m
1 stop
$328Delta
Sat, Aug 8 - Mon, Aug 10
Southwest Logo
8:35 am - 2:30 pm
STL
-
ECP
5h 55m
1 stop
Southwest Logo
10:15 am - 5:45 pm
ECP
-
STL
7h 30m
1 stop
$338Southwest
Thu, Oct 1 - Wed, Oct 7
Southwest Logo
8:35 am - 2:30 pm
STL
-
ECP
5h 55m
1 stop
Southwest Logo
7:40 am - 3:00 pm
ECP
-
STL
7h 20m
2 stops
$343Southwest
Thu, Oct 1 - Wed, Oct 7
Delta Logo
6:54 pm - 11:25 pm
STL
-
ECP
4h 31m
1 stop
Delta Logo
11:21 am - 4:23 pm
ECP
-
STL
5h 02m
1 stop
$348Delta
Thu, Oct 1 - Wed, Oct 7
Delta Logo
11:00 am - 3:25 pm
STL
-
ECP
4h 25m
1 stop
Delta Logo
6:51 pm - 11:58 pm
ECP
-
STL
5h 07m
1 stop
$349Delta
Mon, Aug 10 - Mon, Aug 17
Southwest Logo
5:15 am - 12:40 pm
STL
-
ECP
7h 25m
1 stop
Southwest Logo
7:05 am - 3:20 pm
ECP
-
STL
8h 15m
2 stops
$364Southwest
Sat, Aug 8 - Mon, Aug 10

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Southwest flights from St. Louis to Panama City, Florida

Our best Southwest deals on St. Louis to Panama City, Florida flight tickets
Southwest
Oct 5
STL3:40 pmLambert-St Louis
1h 45m
ECP5:25 pmPanama City NW Florida Beaches
Oct 10
ECP5:55 amPanama City NW Florida Beaches
1h 50m
STL7:45 amLambert-St Louis
$318
Southwest
Aug 4
STL8:35 amLambert-St Louis
6h 25m
2 stops
ECP3:00 pmPanama City NW Florida Beaches
Aug 12
ECP4:20 pmPanama City NW Florida Beaches
5h 50m
1 stop
STL10:10 pmLambert-St Louis
$322
Southwest
Aug 4
STL12:45 pmLambert-St Louis
7h 45m
2 stops
ECP8:30 pmPanama City NW Florida Beaches
Aug 12
ECP11:30 amPanama City NW Florida Beaches
8h 25m
2 stops
STL7:55 pmLambert-St Louis
$327

Delta flights from St. Louis to Panama City, Florida

Our best Delta deals on St. Louis to Panama City, Florida flight tickets
Delta
Aug 4
STL5:23 pmLambert-St Louis
4h 17m
1 stop
ECP9:40 pmPanama City NW Florida Beaches
Aug 12
ECP6:00 amPanama City NW Florida Beaches
3h 54m
1 stop
STL9:54 amLambert-St Louis
$307
Delta
Oct 1
STL6:54 pmLambert-St Louis
4h 31m
1 stop
ECP11:25 pmPanama City NW Florida Beaches
Oct 7
ECP11:21 amPanama City NW Florida Beaches
5h 02m
1 stop
STL4:23 pmLambert-St Louis
$348
Delta
Aug 10
STL11:00 amLambert-St Louis
4h 25m
1 stop
ECP3:25 pmPanama City NW Florida Beaches
Aug 17
ECP6:51 pmPanama City NW Florida Beaches
5h 07m
1 stop
STL11:58 pmLambert-St Louis
$349

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 7, 2026.
Use the filters below to find and compare flights from St. Louis to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Tue 8/4

5:23 pm-9:40 pm

1 stop4h 17m

Panama City NW Florida Beaches

Wed 8/12

6:00 am-9:54 am

1 stop3h 54m

$307
Quickest round-trip

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Mon 10/5

3:40 pm-5:25 pm

Nonstop1h 45m

Panama City NW Florida Beaches

Sat 10/10

5:55 am-7:45 am

Nonstop1h 50m

$318

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Tue 8/4

8:35 am-3:00 pm

2 stops6h 25m

Panama City NW Florida Beaches

Wed 8/12

4:20 pm-10:10 pm

1 stop5h 50m

$322

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Tue 8/4

12:45 pm-8:30 pm

2 stops7h 45m

Panama City NW Florida Beaches

Wed 8/12

11:30 am-7:55 pm

2 stops8h 25m

$327

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sat 8/8

1:04 pm-6:35 pm

1 stop5h 31m

Panama City NW Florida Beaches

Mon 8/10

6:00 am-11:46 am

1 stop5h 46m

$328

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Thu 10/1

8:35 am-2:30 pm

1 stop5h 55m

Panama City NW Florida Beaches

Wed 10/7

10:15 am-5:45 pm

1 stop7h 30m

$338

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Thu 10/1

8:35 am-2:30 pm

1 stop5h 55m

Panama City NW Florida Beaches

Wed 10/7

7:40 am-3:00 pm

2 stops7h 20m

$343

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Thu 10/1

6:54 pm-11:25 pm

1 stop4h 31m

Panama City NW Florida Beaches

Wed 10/7

11:21 am-4:23 pm

1 stop5h 02m

$348

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Mon 8/10

11:00 am-3:25 pm

1 stop4h 25m

Panama City NW Florida Beaches

Mon 8/17

6:51 pm-11:58 pm

1 stop5h 07m

$349

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sat 8/8

5:15 am-12:40 pm

1 stop7h 25m

Panama City NW Florida Beaches

Mon 8/10

7:05 am-3:20 pm

2 stops8h 15m

$364

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
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See travel insights to Panama City from

How to get the cheapest flight ticket from St. Louis to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between St. Louis and Panama City, Florida?

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from St. Louis is in December. Flight prices, which tend to average around $302, are often lower during this time because this is during the off-season. The month of November is another great option to travel to Panama City, Florida, with average flight prices from St. Louis averaging around $303.

What is the cheapest day to depart on your flight to Panama City, Florida?

Our data shows that Tuesday is the least expensive day to fly to Panama City, Florida. Tickets to fly out on this day can be as low as $364. On the other hand, Sunday is the most expensive day to depart from St. Louis because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $525.

What is the cheapest Lambert-St Louis to Panama City NW Florida Beaches flight route?

Fly from Lambert-St Louis to Panama City NW Florida Beaches for the best Lambert-St Louis - Panama City NW Florida Beaches flight prices

How far in advance should I book a flight from St. Louis to Panama City, Florida?

You are more likely to see cheaper flights to Panama City, Florida from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City, Florida for around $366 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City, Florida from St. Louis for as low as $324 on momondo.

What cabin class options are available on St. Louis to Panama City, Florida flights?

There is only 1 cabin class available to choose from on St. Louis to Panama City, Florida flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on St. Louis to Panama City, Florida flights?

No. A direct flight is the cheapest option for a flight between St. Louis to Panama City, Florida.

How have St. Louis to Panama City, Florida flight prices changed over time?

As of July 2026, prices for St. Louis to Panama City, Florida flights are approximately 22% more expensive when compared to flights at the same time last year.

When to book flights from St. Louis to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Panama City, Florida (STL to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Panama City, Florida

Best Price Found

$233

Fastest flight time

1h 45m

Direct flights

Every day

Airports in Panama City, Florida

1 airport
The best one-way flight to Panama City, Florida from St. Louis in the past 72 hours is $233. The best round-trip flight deal from St. Louis to Panama City, Florida found on momondo in the last 72 hours is $373.
The fastest flight from St. Louis to Panama City, Florida takes 1h 45m
Direct flights go from St. Louis to Panama City, Florida every day.
There is 1 airport in Panama City, Florida. From St. Louis there are direct flights to Panama City NW Florida Beaches (ECP).
Search flight deals

Frequently asked questions about flying from St. Louis to Panama City, Florida

  • How far is Lambert-St Louis to Panama City NW Florida Beaches by plane?

    The straight-line distance from Lambert-St Louis to Panama City NW Florida Beaches is 639.0 mi. 1h 45m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The necessary travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from St. Louis to Panama City, Florida?

  • What is the most popular airline from St. Louis to Panama City, Florida?

Best airlines flying from St. Louis to Panama City, Florida

Compare and see reviews for airlines that fly from St. Louis to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $176Free CancellationRating
7.8
8,450 reviews
Search Delta flights
American AirlinesPriceFrom $186Free CancellationRating
7.1
11,784 reviews
Search American Airlines flights
SouthwestPriceFrom $208Free CancellationRating
7.9
4,250 reviews
Search Southwest flights

  • Southwest Flights From St. Louis to Panama City, Florida

    The lowest priced Southwest flight from St. Louis to Panama City, Florida from the last 72 hours was $208. Generally, Southwest has 5 flights on this route every week with an average price of $427. Southwest is rated 7.9/10 by our users.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Panama City with flexible booking policies on momondo?

Flights from St. Louis to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from St. Louis to Panama City.

I’m not ready to book a flight from St. Louis to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for St. Louis to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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