Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from St. Louis to Panama City from $158

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Panama City departing on 7/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from St. Louis to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
9:24 am - 4:12 pm
STL
-
ECP
6h 48m
1 stop
Delta Logo
6:48 pm - 11:53 pm
ECP
-
STL
5h 05m
1 stop
$315Delta
Wed, Jul 22 - Mon, Jul 27
Delta Logo
3:57 pm - 8:47 pm
STL
-
ECP
4h 50m
1 stop
Delta Logo
6:45 pm - 11:56 pm
ECP
-
STL
5h 11m
1 stop
$317Delta
Mon, Jun 15 - Fri, Jun 19
American Airlines Logo
5:43 am - 12:02 pm
STL
-
ECP
6h 19m
1 stop
American Airlines Logo
1:32 pm - 12:27 am
ECP
-
STL
10h 55m
2 stops
$320American Airlines
Sat, Sep 26 - Tue, Sep 29
American Airlines Logo
9:42 am - 4:21 pm
STL
-
ECP
6h 39m
1 stop
American Airlines Logo
4:16 pm - 12:16 am
ECP
-
STL
8h 00m
2 stops
$322American Airlines
Mon, Jun 15 - Fri, Jun 19
American Airlines Logo
10:34 am - 6:50 pm
STL
-
ECP
8h 16m
2 stops
American Airlines Logo
2:36 pm - 10:24 pm
ECP
-
STL
7h 48m
2 stops
$325American Airlines
Sat, Sep 26 - Tue, Sep 29
Southwest Logo
7:25 pm - 9:10 pm
STL
-
ECP
1h 45mnonstop
Southwest Logo
6:20 pm - 10:45 pm
ECP
-
STL
4h 25m
1 stop
$326Southwest
Wed, Jun 24 - Mon, Jun 29
Southwest Logo
12:40 pm - 7:45 pm
STL
-
ECP
7h 05m
2 stops
Southwest Logo
6:05 pm - 11:15 pm
ECP
-
STL
5h 10m
1 stop
$336Southwest
Tue, Jul 7 - Sat, Jul 11
Southwest Logo
7:25 pm - 9:10 pm
STL
-
ECP
1h 45mnonstop
Southwest Logo
5:30 pm - 7:20 pm
ECP
-
STL
1h 50mnonstop
$337Southwest
Wed, Jun 17 - Wed, Jun 24
Southwest Logo
2:50 pm - 9:50 pm
STL
-
ECP
7h 00m
1 stop
Southwest Logo
1:40 pm - 3:25 pm
ECP
-
STL
1h 45mnonstop
$338Southwest
Sun, Aug 16 - Sat, Aug 22
Delta Logo
7:00 am - 12:49 pm
STL
-
ECP
5h 49m
1 stop
Delta Logo
4:28 pm - 8:55 am
ECP
-
STL
16h 27m
1 stop
$340Delta
Thu, Sep 3 - Mon, Sep 14

Delta flights from St. Louis to Panama City, Florida

Our best Delta deals on St. Louis to Panama City, Florida flight tickets
Delta
Jun 15
STL3:57 pmLambert-St Louis
4h 50m
1 stop
ECP8:47 pmPanama City NW Florida Beaches
Jun 19
ECP6:45 pmPanama City NW Florida Beaches
5h 11m
1 stop
STL11:56 pmLambert-St Louis
$317
Delta
Sep 3
STL7:00 amLambert-St Louis
5h 49m
1 stop
ECP12:49 pmPanama City NW Florida Beaches
Sep 14
ECP4:28 pmPanama City NW Florida Beaches
16h 27m
1 stop
STL8:55 amLambert-St Louis
$340
Delta
Oct 22
STL5:30 pmLambert-St Louis
5h 17m
1 stop
ECP10:47 pmPanama City NW Florida Beaches
Nov 1
ECP7:05 pmPanama City NW Florida Beaches
13h 07m
1 stop
STL8:12 amLambert-St Louis
$350

American Airlines flights from St. Louis to Panama City, Florida

Our best American Airlines deals on St. Louis to Panama City, Florida flight tickets
American Airlines
Sep 26
STL5:43 amLambert-St Louis
6h 19m
1 stop
ECP12:02 pmPanama City NW Florida Beaches
Sep 29
ECP1:32 pmPanama City NW Florida Beaches
10h 55m
2 stops
STL12:27 amLambert-St Louis
$320
American Airlines
Jun 15
STL9:42 amLambert-St Louis
6h 39m
1 stop
ECP4:21 pmPanama City NW Florida Beaches
Jun 19
ECP4:16 pmPanama City NW Florida Beaches
8h 00m
2 stops
STL12:16 amLambert-St Louis
$322
American Airlines
Sep 26
STL10:34 amLambert-St Louis
8h 16m
2 stops
ECP6:50 pmPanama City NW Florida Beaches
Sep 29
ECP2:36 pmPanama City NW Florida Beaches
7h 48m
2 stops
STL10:24 pmLambert-St Louis
$325

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 25, 2026.
Use the filters below to find and compare flights from St. Louis to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Wed 7/22

9:24 am-4:12 pm

1 stop6h 48m

Panama City NW Florida Beaches

Mon 7/27

6:48 pm-11:53 pm

1 stop5h 05m

$315

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Mon 6/15

3:57 pm-8:47 pm

1 stop4h 50m

Panama City NW Florida Beaches

Fri 6/19

6:45 pm-11:56 pm

1 stop5h 11m

$317

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sat 9/26

5:43 am-12:02 pm

1 stop6h 19m

Panama City NW Florida Beaches

Tue 9/29

1:32 pm-12:27 am

2 stops10h 55m

$320

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Mon 6/15

9:42 am-4:21 pm

1 stop6h 39m

Panama City NW Florida Beaches

Fri 6/19

4:16 pm-12:16 am

2 stops8h 00m

$322

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sat 9/26

10:34 am-6:50 pm

2 stops8h 16m

Panama City NW Florida Beaches

Tue 9/29

2:36 pm-10:24 pm

2 stops7h 48m

$325

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Wed 6/24

7:25 pm-9:10 pm

Nonstop1h 45m

Panama City NW Florida Beaches

Mon 6/29

6:20 pm-10:45 pm

1 stop4h 25m

$326

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Tue 7/7

12:40 pm-7:45 pm

2 stops7h 05m

Panama City NW Florida Beaches

Sat 7/11

6:05 pm-11:15 pm

1 stop5h 10m

$336
Quickest round-trip

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Wed 6/17

7:25 pm-9:10 pm

Nonstop1h 45m

Panama City NW Florida Beaches

Wed 6/24

5:30 pm-7:20 pm

Nonstop1h 50m

$337

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sun 8/16

2:50 pm-9:50 pm

1 stop7h 00m

Panama City NW Florida Beaches

Sat 8/22

1:40 pm-3:25 pm

Nonstop1h 45m

$338

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Thu 9/3

7:00 am-12:49 pm

1 stop5h 49m

Panama City NW Florida Beaches

Mon 9/14

4:28 pm-8:55 am

1 stop16h 27m

$340

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Panama City from

How to get the cheapest flight ticket from St. Louis to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between St. Louis and Panama City, Florida?

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from St. Louis is in October. Flight prices, which tend to average around $280, are often lower during this time because this is during the off-season. The month of December is another great option to travel to Panama City, Florida, with average flight prices from St. Louis averaging around $288.

What is the cheapest day to depart on your flight to Panama City, Florida?

Our data shows that Tuesday is the least expensive day to fly to Panama City, Florida. Tickets to fly out on this day can be as low as $330. On the other hand, Saturday is the most expensive day to depart from St. Louis because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $447.

What is the cheapest Lambert-St Louis to Panama City NW Florida Beaches flight route?

Fly from Lambert-St Louis to Panama City NW Florida Beaches for the best Lambert-St Louis - Panama City NW Florida Beaches flight prices

How far in advance should I book a flight from St. Louis to Panama City, Florida?

You are more likely to see cheaper flights to Panama City, Florida from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City, Florida for around $352 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City, Florida from St. Louis for as low as $281 on momondo.

What cabin class options are available on St. Louis to Panama City, Florida flights?

There is only 1 cabin class available to choose from on St. Louis to Panama City, Florida flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on St. Louis to Panama City, Florida flights?

You could potentially save up to 2% on your flight if you consider stops on a St. Louis to Panama City, Florida flight.

How have St. Louis to Panama City, Florida flight prices changed over time?

As of May 2026, prices for St. Louis to Panama City, Florida flights are approximately 59% more expensive when compared to flights at the same time last year.

When to book flights from St. Louis to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Panama City, Florida (STL to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Panama City, Florida

Best Price Found

$443

Fastest flight time

1h 45m

Direct flights

Every day

Airports in Panama City, Florida

1 airport
The best flight deal from St. Louis to Panama City, Florida found on momondo in the last 72 hours is $443
The fastest flight from St. Louis to Panama City, Florida takes 1h 45m
Direct flights go from St. Louis to Panama City, Florida every day.
There is 1 airport in Panama City, Florida. From St. Louis there are direct flights to Panama City NW Florida Beaches (ECP).
Search flight deals

Frequently asked questions about flying from St. Louis to Panama City, Florida

  • How far is Lambert-St Louis to Panama City NW Florida Beaches by plane?

    The straight-line distance from Lambert-St Louis to Panama City NW Florida Beaches is 639.0 mi. 1h 45m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The necessary travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from St. Louis to Panama City, Florida?

  • What is the most popular airline from St. Louis to Panama City, Florida?

Best airlines flying from St. Louis to Panama City, Florida

Compare and see reviews for airlines that fly from St. Louis to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $176Free CancellationRating
7.9
8,433 reviews
Search Delta flights
American AirlinesPriceFrom $186Free CancellationRating
7.1
11,628 reviews
Search American Airlines flights
SouthwestPriceFrom $195Free CancellationRating
7.9
4,269 reviews
Search Southwest flights

  • Southwest Flights From St. Louis to Panama City, Florida

    The lowest priced Southwest flight from St. Louis to Panama City, Florida from the last 72 hours was $195. Generally, Southwest has 5 flights on this route every week with an average price of $415. Southwest is rated 7.9/10 by our users.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Panama City with flexible booking policies on momondo?

Flights from St. Louis to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from St. Louis to Panama City.

I’m not ready to book a flight from St. Louis to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for St. Louis to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your Panama City, Florida trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Wed 6/24
Wed 7/1
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States