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Cheap flights from St. Louis to Panama City from $86

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Panama City departing on 10/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

American Airlines Logo
7:23 am - 2:10 pmSTL-ECP
6h 47m1 stop
American Airlines Logo
2:40 pm - 7:30 pmECP-STL
4h 50m1 stop
$207American Airlines
Find Deal
Mon, Oct 27 - Sat, Nov 1
American Airlines Logo
5:11 am - 10:58 amSTL-ECP
5h 47m1 stop
American Airlines Logo
5:30 am - 4:04 pmECP-STL
10h 34m2 stops
$212American Airlines
Find Deal
Mon, Oct 27 - Sat, Nov 1
Delta Logo
7:10 am - 1:20 pmSTL-ECP
6h 10m1 stop
Delta Logo
6:00 am - 10:26 amECP-STL
4h 26m1 stop
$227Delta
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Fri, Oct 3 - Tue, Oct 7
United Airlines Logo
4:35 pm - 9:59 pmSTL-ECP
5h 24m1 stop
United Airlines Logo
4:55 pm - 10:06 pmECP-STL
5h 11m1 stop
$237United Airlines
Find Deal
Sat, Feb 7 - Sat, Feb 14
United Airlines Logo
6:00 am - 12:02 pmSTL-ECP
6h 02m1 stop
United Airlines Logo
6:40 am - 2:18 pmECP-STL
7h 38m2 stops
$242United Airlines
Find Deal
Sat, Feb 7 - Sat, Feb 14
Delta Logo
6:00 am - 10:19 amSTL-ECP
4h 19m1 stop
Delta Logo
6:00 am - 12:35 pmECP-STL
6h 35m1 stop
$243Delta
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Tue, Nov 4 - Fri, Nov 7
Delta Logo
5:11 pm - 11:03 pmSTL-ECP
5h 52m1 stop
Delta Logo
6:29 pm - 11:41 pmECP-STL
5h 12m1 stop
$246Delta
Find Deal
Sat, Oct 4 - Mon, Oct 6
Delta Logo
6:00 am - 12:40 pmSTL-ECP
6h 40m1 stop
Delta Logo
7:05 pm - 11:40 pmECP-STL
4h 35m1 stop
$249Delta
Find Deal
Tue, Feb 24 - Thu, Feb 26
Southwest Logo
8:35 am - 10:20 amSTL-ECP
1h 45mnonstop
Southwest Logo
4:10 pm - 9:00 pmECP-STL
4h 50m1 stop
$269Southwest
Find Deal
Mon, Oct 27 - Sat, Nov 1
Southwest Logo
10:15 am - 3:15 pmSTL-ECP
5h 00m1 stop
Southwest Logo
3:15 pm - 5:00 pmECP-STL
1h 45mnonstop
$295Southwest
Find Deal
Wed, Oct 8 - Wed, Oct 15

Delta flights from St. Louis to Panama City, Florida

Our best Delta deals on St. Louis to Panama City, Florida flight tickets
Delta
Oct 3
STL7:10 amLambert-St Louis
6h 10m
1 stop
ECP1:20 pmPanama City NW Florida Beaches
Oct 7
ECP6:00 amPanama City NW Florida Beaches
4h 26m
1 stop
STL10:26 amLambert-St Louis
$227
Find similar
Delta
Nov 4
STL6:00 amLambert-St Louis
4h 19m
1 stop
ECP10:19 amPanama City NW Florida Beaches
Nov 7
ECP6:00 amPanama City NW Florida Beaches
6h 35m
1 stop
STL12:35 pmLambert-St Louis
$243
Find similar
Delta
Oct 4
STL5:11 pmLambert-St Louis
5h 52m
1 stop
ECP11:03 pmPanama City NW Florida Beaches
Oct 6
ECP6:29 pmPanama City NW Florida Beaches
5h 12m
1 stop
STL11:41 pmLambert-St Louis
$246
Find similar

American Airlines flights from St. Louis to Panama City, Florida

Our best American Airlines deals on St. Louis to Panama City, Florida flight tickets
American Airlines
Oct 27
STL7:23 amLambert-St Louis
6h 47m
1 stop
ECP2:10 pmPanama City NW Florida Beaches
Nov 1
ECP2:40 pmPanama City NW Florida Beaches
4h 50m
1 stop
STL7:30 pmLambert-St Louis
$207
Find similar
American Airlines
Oct 27
STL5:11 amLambert-St Louis
5h 47m
1 stop
ECP10:58 amPanama City NW Florida Beaches
Nov 1
ECP5:30 amPanama City NW Florida Beaches
10h 34m
2 stops
STL4:04 pmLambert-St Louis
$212
Find similar
American Airlines
Oct 19
STL6:00 amLambert-St Louis
7h 21m
1 stop
ECP1:21 pmPanama City NW Florida Beaches
Oct 23
ECP3:38 pmPanama City NW Florida Beaches
5h 13m
1 stop
STL8:51 pmLambert-St Louis
$252
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from St. Louis to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Mon 10/27

7:23 am-2:10 pm

1 stop6h 47m

Panama City NW Florida Beaches

Sat 11/1

2:40 pm-7:30 pm

1 stop4h 50m

$207

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Mon 10/27

5:11 am-10:58 am

1 stop5h 47m

Panama City NW Florida Beaches

Sat 11/1

5:30 am-4:04 pm

2 stops10h 34m

$212

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Fri 10/3

7:10 am-1:20 pm

1 stop6h 10m

Panama City NW Florida Beaches

Tue 10/7

6:00 am-10:26 am

1 stop4h 26m

$227

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sat 2/7

4:35 pm-9:59 pm

1 stop5h 24m

Panama City NW Florida Beaches

Sat 2/14

4:55 pm-10:06 pm

1 stop5h 11m

$237

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sat 2/7

6:00 am-12:02 pm

1 stop6h 02m

Panama City NW Florida Beaches

Sat 2/14

6:40 am-2:18 pm

2 stops7h 38m

$242

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Tue 11/4

6:00 am-10:19 am

1 stop4h 19m

Panama City NW Florida Beaches

Fri 11/7

6:00 am-12:35 pm

1 stop6h 35m

$243

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sat 10/4

5:11 pm-11:03 pm

1 stop5h 52m

Panama City NW Florida Beaches

Mon 10/6

6:29 pm-11:41 pm

1 stop5h 12m

$246

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Tue 2/24

6:00 am-12:40 pm

1 stop6h 40m

Panama City NW Florida Beaches

Thu 2/26

7:05 pm-11:40 pm

1 stop4h 35m

$249

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Mon 10/27

8:35 am-10:20 am

Nonstop1h 45m

Panama City NW Florida Beaches

Sat 11/1

4:10 pm-9:00 pm

1 stop4h 50m

$269

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Wed 10/8

10:15 am-3:15 pm

1 stop5h 00m

Panama City NW Florida Beaches

Wed 10/15

3:15 pm-5:00 pm

Nonstop1h 45m

$295

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from St. Louis to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from St. Louis is in September. Flight prices, which tend to average around $361, are often lower during this time because this is during the off-season. The month of January is another great option to travel to Panama City, Florida, with average flight prices from St. Louis averaging around $404.

What is the cheapest day to depart on your flight to Panama City, Florida?

Our data shows that Tuesday is the least expensive day to fly to Panama City, Florida. Tickets to fly out on this day can be as low as $355. On the other hand, Saturday is the most expensive day to depart from St. Louis because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $473.

What is the cheapest Lambert-St Louis to Panama City NW Florida Beaches flight route?

Fly from Lambert-St Louis to Panama City NW Florida Beaches for the best Lambert-St Louis - Panama City NW Florida Beaches flight prices

How far in advance should I book a flight to Panama City, Florida?

You are more likely to see cheaper flights to Panama City, Florida from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City, Florida for around $410 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City, Florida from St. Louis for as low as $300 on momondo.

What cabin class options are available on Lambert-St Louis to Panama City NW Florida Beaches flights?

There is only 1 cabin class available to choose from on Lambert-St Louis to Panama City NW Florida Beaches flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have St. Louis to Panama City, Florida flight prices changed over time?

As of September 2025, prices for St. Louis to Panama City, Florida flights are approximately 111% more expensive when compared to flights at the same time last year.

When to book flights from St. Louis to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Panama City, Florida (STL to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Panama City, Florida

Best Price Found

$192

Fastest flight time

1h 45m

Direct flights

Every day

Airports in Panama City, Florida

1 airport
The best flight deal from St. Louis to Panama City, Florida found on momondo in the last 72 hours is $192
The fastest flight from St. Louis to Panama City, Florida takes 1h 45m
Direct flights go from St. Louis to Panama City, Florida every day.
There is 1 airport near Panama City, Florida: Panama City NW Florida Beaches (ECP)
Search flight deals

  • How far is Lambert-St Louis to Panama City NW Florida Beaches by plane?

    The straight-line distance from Lambert-St Louis to Panama City NW Florida Beaches is 639.0 mi. 1h 45m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The necessary travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from St. Louis to Panama City, Florida?

  • What is the most popular airline from St. Louis to Panama City, Florida?

Best airlines flying from St. Louis to Panama City, Florida

Compare and see reviews for airlines that fly from St. Louis to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $102Free CancellationRating
7.2
702 reviews
Search Allegiant Air flights
DeltaPriceFrom $186Free CancellationRating
7.9
7,960 reviews
Search Delta flights
American AirlinesPriceFrom $212Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
SouthwestPriceFrom $232Free CancellationRating
8.0
4,248 reviews
Search Southwest flights

  • Southwest Flights From St. Louis to Panama City, Florida

    The lowest priced Southwest flight from St. Louis to Panama City, Florida from the last 72 hours was $232. Generally, Southwest has 5 flights on this route every week with an average price of $435. Southwest is rated 8.0/10 by our users.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Panama City with flexible booking policies on momondo?

Flights from St. Louis to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from St. Louis to Panama City.

I’m not ready to book a flight from St. Louis to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for St. Louis to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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