Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from St. Louis to Panama City from $145

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Panama City departing on 1/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from St. Louis to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
7:10 am - 11:08 am
STL
-
ECP
3h 58m1 stop
Delta Logo
7:20 am - 11:54 am
ECP
-
STL
4h 34m1 stop
$289Delta
Sun, Jan 25 - Sat, Jan 31
American Airlines Logo
3:54 pm - 9:19 pm
STL
-
ECP
5h 25m1 stop
American Airlines Logo
12:03 pm - 8:13 pm
ECP
-
STL
8h 10m2 stops
$294American Airlines
Sat, Jan 24 - Sat, Jan 31
United Airlines Logo
6:30 am - 4:12 pm
STL
-
ECP
9h 42m2 stops
United Airlines Logo
6:30 am - 7:27 pm
ECP
-
STL
12h 57m2 stops
$299United Airlines
Sat, Jan 24 - Sat, Jan 31
Southwest Logo
12:45 pm - 2:30 pm
STL
-
ECP
1h 45mnonstop
Southwest Logo
7:30 am - 2:35 pm
ECP
-
STL
7h 05m1 stop
$309Southwest
Wed, Mar 11 - Tue, Mar 17
American Airlines Logo
6:00 am - 1:10 pm
STL
-
ECP
7h 10m1 stop
American Airlines Logo
1:34 pm - 9:51 pm
ECP
-
STL
8h 17m1 stop
$314American Airlines
Sat, Jan 17 - Tue, Jan 20
American Airlines Logo
6:58 pm - 11:52 pm
STL
-
ECP
4h 54m1 stop
American Airlines Logo
1:50 pm - 10:09 pm
ECP
-
STL
8h 19m2 stops
$319American Airlines
Thu, Feb 19 - Wed, Feb 25
American Airlines Logo
9:54 am - 5:33 pm
STL
-
ECP
7h 39m2 stops
American Airlines Logo
12:03 pm - 9:51 pm
ECP
-
STL
9h 48m2 stops
$324American Airlines
Mon, Jan 26 - Mon, Feb 2
Southwest Logo
8:50 pm - 11:55 am
STL
-
ECP
15h 05m2 stops
Southwest Logo
4:30 pm - 8:10 pm
ECP
-
STL
3h 40m1 stop
$325Southwest
Thu, Feb 19 - Mon, Feb 23
Southwest Logo
8:50 pm - 11:55 am
STL
-
ECP
15h 05m2 stops
Southwest Logo
8:00 am - 5:30 pm
ECP
-
STL
9h 30m2 stops
$330Southwest
Thu, Feb 19 - Wed, Feb 25
American Airlines Logo
6:58 pm - 11:52 pm
STL
-
ECP
4h 54m1 stop
American Airlines Logo
10:25 am - 6:08 pm
ECP
-
STL
7h 43m1 stop
$339American Airlines
Thu, Feb 19 - Mon, Feb 23

United Airlines flights from St. Louis to Panama City, Florida

Our best United Airlines deals on St. Louis to Panama City, Florida flight tickets
United Airlines
Jan 24
STL6:30 amLambert-St Louis
9h 42m
2 stops
ECP4:12 pmPanama City NW Florida Beaches
Jan 31
ECP6:30 amPanama City NW Florida Beaches
12h 57m
2 stops
STL7:27 pmLambert-St Louis
$299
Find similar
United Airlines
Jan 7
STL6:00 amLambert-St Louis
6h 02m
1 stop
ECP12:02 pmPanama City NW Florida Beaches
Jan 12
ECP4:54 pmPanama City NW Florida Beaches
5h 06m
1 stop
STL10:00 pmLambert-St Louis
$355
Find similar
United Airlines
Mar 3
STL6:00 amLambert-St Louis
6h 04m
1 stop
ECP12:04 pmPanama City NW Florida Beaches
Mar 4
ECP5:00 pmPanama City NW Florida Beaches
5h 14m
1 stop
STL10:14 pmLambert-St Louis
$359
Find similar

American Airlines flights from St. Louis to Panama City, Florida

Our best American Airlines deals on St. Louis to Panama City, Florida flight tickets
American Airlines
Jan 24
STL3:54 pmLambert-St Louis
5h 25m
1 stop
ECP9:19 pmPanama City NW Florida Beaches
Jan 31
ECP12:03 pmPanama City NW Florida Beaches
8h 10m
2 stops
STL8:13 pmLambert-St Louis
$294
Find similar
American Airlines
Jan 17
STL6:00 amLambert-St Louis
7h 10m
1 stop
ECP1:10 pmPanama City NW Florida Beaches
Jan 20
ECP1:34 pmPanama City NW Florida Beaches
8h 17m
1 stop
STL9:51 pmLambert-St Louis
$314
Find similar
American Airlines
Feb 19
STL6:58 pmLambert-St Louis
4h 54m
1 stop
ECP11:52 pmPanama City NW Florida Beaches
Feb 25
ECP1:50 pmPanama City NW Florida Beaches
8h 19m
2 stops
STL10:09 pmLambert-St Louis
$319
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 28, 2025.
Use the filters below to find and compare flights from St. Louis to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sun 1/25

7:10 am-11:08 am

1 stop3h 58m

Panama City NW Florida Beaches

Sat 1/31

7:20 am-11:54 am

1 stop4h 34m

$289

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sat 1/24

3:54 pm-9:19 pm

1 stop5h 25m

Panama City NW Florida Beaches

Sat 1/31

12:03 pm-8:13 pm

2 stops8h 10m

$294

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sat 1/24

6:30 am-4:12 pm

2 stops9h 42m

Panama City NW Florida Beaches

Sat 1/31

6:30 am-7:27 pm

2 stops12h 57m

$299

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Wed 3/11

12:45 pm-2:30 pm

Nonstop1h 45m

Panama City NW Florida Beaches

Tue 3/17

7:30 am-2:35 pm

1 stop7h 05m

$309

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sat 1/17

6:00 am-1:10 pm

1 stop7h 10m

Panama City NW Florida Beaches

Tue 1/20

1:34 pm-9:51 pm

1 stop8h 17m

$314

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Thu 2/19

6:58 pm-11:52 pm

1 stop4h 54m

Panama City NW Florida Beaches

Wed 2/25

1:50 pm-10:09 pm

2 stops8h 19m

$319

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Mon 1/26

9:54 am-5:33 pm

2 stops7h 39m

Panama City NW Florida Beaches

Mon 2/2

12:03 pm-9:51 pm

2 stops9h 48m

$324

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Thu 2/19

8:50 pm-11:55 am

2 stops15h 05m

Panama City NW Florida Beaches

Mon 2/23

4:30 pm-8:10 pm

1 stop3h 40m

$325

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Thu 2/19

8:50 pm-11:55 am

2 stops15h 05m

Panama City NW Florida Beaches

Wed 2/25

8:00 am-5:30 pm

2 stops9h 30m

$330

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Thu 2/19

6:58 pm-11:52 pm

1 stop4h 54m

Panama City NW Florida Beaches

Mon 2/23

10:25 am-6:08 pm

1 stop7h 43m

$339

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Panama City from

How to get the cheapest flight ticket from St. Louis to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from St. Louis is in October. Flight prices, which tend to average around $279, are often lower during this time because this is during the off-season. The month of December is another great option to travel to Panama City, Florida, with average flight prices from St. Louis averaging around $302.

What is the cheapest day to depart on your flight to Panama City, Florida?

Our data shows that Wednesday is the least expensive day to fly to Panama City, Florida. Tickets to fly out on this day can be as low as $353. On the other hand, Saturday is the most expensive day to depart from St. Louis because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $472.

What is the cheapest Lambert-St Louis to Panama City NW Florida Beaches flight route?

Fly from Lambert-St Louis to Panama City NW Florida Beaches for the best Lambert-St Louis - Panama City NW Florida Beaches flight prices

How far in advance should I book a flight to Panama City, Florida?

You are more likely to see cheaper flights to Panama City, Florida from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City, Florida for around $371 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City, Florida from St. Louis for as low as $311 on momondo.

What cabin class options are available on Lambert-St Louis to Panama City NW Florida Beaches flights?

There is only 1 cabin class available to choose from on Lambert-St Louis to Panama City NW Florida Beaches flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have St. Louis to Panama City, Florida flight prices changed over time?

As of December 2025, prices for St. Louis to Panama City, Florida flights are approximately 31% cheaper when compared to flights at the same time last year.

When to book flights from St. Louis to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Panama City, Florida (STL to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Panama City, Florida

Best Price Found

$374

Fastest flight time

1h 45m

Direct flights

Mon, Tue, Thu, Fri, Sat and Sun

Airports in Panama City, Florida

1 airport
The best flight deal from St. Louis to Panama City, Florida found on momondo in the last 72 hours is $374
The fastest flight from St. Louis to Panama City, Florida takes 1h 45m
Direct flights go from St. Louis to Panama City, Florida on Monday, Tuesday, Thursday, Friday, Saturday and Sunday. There are no airlines offering direct flights.
There is 1 airport in Panama City, Florida. From St. Louis there are direct flights to Panama City NW Florida Beaches (ECP).
Search flight deals

  • How far is Lambert-St Louis to Panama City NW Florida Beaches by plane?

    The straight-line distance from Lambert-St Louis to Panama City NW Florida Beaches is 639.0 mi. 1h 45m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The necessary travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from St. Louis to Panama City, Florida?

  • What is the most popular airline from St. Louis to Panama City, Florida?

Best airlines flying from St. Louis to Panama City, Florida

Compare and see reviews for airlines that fly from St. Louis to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $176Free CancellationRating
7.9
8,019 reviews
Search Delta flights
American AirlinesPriceFrom $212Free CancellationRating
7.2
11,073 reviews
Search American Airlines flights
SouthwestPriceFrom $228Free CancellationRating
8.0
4,256 reviews
Search Southwest flights

  • Southwest Flights From St. Louis to Panama City, Florida

    The lowest priced Southwest flight from St. Louis to Panama City, Florida from the last 72 hours was $228. Generally, Southwest has 1 flight on this route every week with an average price of $424. Southwest is rated 8.0/10 by our users.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Panama City with flexible booking policies on momondo?

Flights from St. Louis to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from St. Louis to Panama City.

I’m not ready to book a flight from St. Louis to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for St. Louis to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your Panama City, Florida trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Tue 1/27
Tue 2/3
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States