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Cheap flights from St. Louis to Panama City from $158

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Panama City departing on 6/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from St. Louis to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
5:40 am - 11:35 am
STL
-
ECP
5h 55m
1 stop
Southwest Logo
7:20 am - 1:35 pm
ECP
-
STL
6h 15m
1 stop
$315Southwest
Mon, May 18 - Sat, May 23
Southwest Logo
3:00 pm - 9:30 pm
STL
-
ECP
6h 30m
1 stop
Southwest Logo
5:25 pm - 11:15 pm
ECP
-
STL
5h 50m
1 stop
$316Southwest
Mon, May 4 - Mon, May 11
Southwest Logo
3:00 pm - 9:30 pm
STL
-
ECP
6h 30m
1 stop
Southwest Logo
6:25 pm - 10:00 pm
ECP
-
STL
3h 35m
1 stop
$317Southwest
Fri, Apr 24 - Tue, Apr 28
Southwest Logo
1:45 pm - 7:50 pm
STL
-
ECP
6h 05m
2 stops
Southwest Logo
12:40 pm - 7:10 pm
ECP
-
STL
6h 30m
1 stop
$320Southwest
Mon, May 18 - Sat, May 23
Southwest Logo
8:30 am - 3:30 pm
STL
-
ECP
7h 00m
2 stops
Southwest Logo
6:50 pm - 12:15 am
ECP
-
STL
5h 25m
1 stop
$321Southwest
Sun, May 3 - Sun, May 10
Southwest Logo
5:25 am - 1:15 pm
STL
-
ECP
7h 50m
2 stops
Southwest Logo
5:35 pm - 11:15 pm
ECP
-
STL
5h 40m
1 stop
$322Southwest
Sun, Apr 26 - Fri, May 1
Southwest Logo
8:25 am - 4:20 pm
STL
-
ECP
7h 55m
2 stops
Southwest Logo
12:05 pm - 8:00 pm
ECP
-
STL
7h 55m
2 stops
$325Southwest
Tue, May 5 - Tue, May 12
Southwest Logo
8:25 am - 4:20 pm
STL
-
ECP
7h 55m
2 stops
Southwest Logo
12:05 pm - 8:00 pm
ECP
-
STL
7h 55m
2 stops
$326Southwest
Wed, May 6 - Wed, May 13
Southwest Logo
6:00 am - 1:15 pm
STL
-
ECP
7h 15m
2 stops
Southwest Logo
7:10 am - 2:55 pm
ECP
-
STL
7h 45m
2 stops
$327Southwest
Sun, Apr 26 - Fri, May 1
Southwest Logo
6:40 pm - 8:25 pm
STL
-
ECP
1h 45mnonstop
Southwest Logo
5:25 pm - 8:55 pm
ECP
-
STL
3h 30m
1 stop
$330Southwest
Tue, May 5 - Mon, May 11

American Airlines flights from St. Louis to Panama City, Florida

Our best American Airlines deals on St. Louis to Panama City, Florida flight tickets
American Airlines
May 17
STL7:05 amLambert-St Louis
5h 31m
1 stop
ECP12:36 pmPanama City NW Florida Beaches
May 20
ECP10:50 amPanama City NW Florida Beaches
11h 29m
2 stops
STL10:19 pmLambert-St Louis
$342
American Airlines
Jun 16
STL5:08 amLambert-St Louis
5h 56m
1 stop
ECP11:04 amPanama City NW Florida Beaches
Jun 20
ECP6:45 pmPanama City NW Florida Beaches
4h 59m
1 stop
STL11:44 pmLambert-St Louis
$367
American Airlines
May 17
STL7:05 amLambert-St Louis
5h 31m
1 stop
ECP12:36 pmPanama City NW Florida Beaches
May 20
ECP7:21 amPanama City NW Florida Beaches
9h 20m
2 stops
STL4:41 pmLambert-St Louis
$372

Southwest flights from St. Louis to Panama City, Florida

Our best Southwest deals on St. Louis to Panama City, Florida flight tickets
Southwest
May 18
STL5:40 amLambert-St Louis
5h 55m
1 stop
ECP11:35 amPanama City NW Florida Beaches
May 18
ECP5:25 pmPanama City NW Florida Beaches
5h 50m
1 stop
STL11:15 pmLambert-St Louis
$315
Southwest
May 4
STL3:00 pmLambert-St Louis
6h 30m
1 stop
ECP9:30 pmPanama City NW Florida Beaches
May 11
ECP5:25 pmPanama City NW Florida Beaches
5h 50m
1 stop
STL11:15 pmLambert-St Louis
$316
Southwest
Apr 24
STL3:00 pmLambert-St Louis
6h 30m
1 stop
ECP9:30 pmPanama City NW Florida Beaches
Apr 28
ECP6:25 pmPanama City NW Florida Beaches
3h 35m
1 stop
STL10:00 pmLambert-St Louis
$317

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 9, 2026.
Use the filters below to find and compare flights from St. Louis to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Mon 5/18

5:40 am-11:35 am

1 stop5h 55m

Panama City NW Florida Beaches

Sat 5/23

7:20 am-1:35 pm

1 stop6h 15m

$315

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Mon 5/4

3:00 pm-9:30 pm

1 stop6h 30m

Panama City NW Florida Beaches

Mon 5/11

5:25 pm-11:15 pm

1 stop5h 50m

$316

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Fri 4/24

3:00 pm-9:30 pm

1 stop6h 30m

Panama City NW Florida Beaches

Tue 4/28

6:25 pm-10:00 pm

1 stop3h 35m

$317

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Mon 5/18

1:45 pm-7:50 pm

2 stops6h 05m

Panama City NW Florida Beaches

Sat 5/23

12:40 pm-7:10 pm

1 stop6h 30m

$320

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sun 5/3

8:30 am-3:30 pm

2 stops7h 00m

Panama City NW Florida Beaches

Sun 5/10

6:50 pm-12:15 am

1 stop5h 25m

$321

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sun 4/26

5:25 am-1:15 pm

2 stops7h 50m

Panama City NW Florida Beaches

Fri 5/1

5:35 pm-11:15 pm

1 stop5h 40m

$322

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Tue 5/5

8:25 am-4:20 pm

2 stops7h 55m

Panama City NW Florida Beaches

Tue 5/12

12:05 pm-8:00 pm

2 stops7h 55m

$325

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Wed 5/6

8:25 am-4:20 pm

2 stops7h 55m

Panama City NW Florida Beaches

Wed 5/13

12:05 pm-8:00 pm

2 stops7h 55m

$326

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Sun 4/26

6:00 am-1:15 pm

2 stops7h 15m

Panama City NW Florida Beaches

Fri 5/1

7:10 am-2:55 pm

2 stops7h 45m

$327
Quickest round-trip

St. LouisPanama City

STL - ECP

STLECP

Lambert-St Louis

Tue 5/5

6:40 pm-8:25 pm

Nonstop1h 45m

Panama City NW Florida Beaches

Mon 5/11

5:25 pm-8:55 pm

1 stop3h 30m

$330

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from St. Louis to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between St. Louis and Panama City, Florida?

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from St. Louis is in October. Flight prices, which tend to average around $279, are often lower during this time because this is during the off-season. The month of December is another great option to travel to Panama City, Florida, with average flight prices from St. Louis averaging around $288.

What is the cheapest day to depart on your flight to Panama City, Florida?

Our data shows that Tuesday is the least expensive day to fly to Panama City, Florida. Tickets to fly out on this day can be as low as $314. On the other hand, Saturday is the most expensive day to depart from St. Louis because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $455.

What is the cheapest Lambert-St Louis to Panama City NW Florida Beaches flight route?

Fly from Lambert-St Louis to Panama City NW Florida Beaches for the best Lambert-St Louis - Panama City NW Florida Beaches flight prices

How far in advance should I book a flight to Panama City, Florida?

You are more likely to see cheaper flights to Panama City, Florida from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Panama City, Florida for around $350 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Panama City, Florida from St. Louis for as low as $292 on momondo.

What cabin class options are available on Lambert-St Louis to Panama City NW Florida Beaches flights?

There is only 1 cabin class available to choose from on Lambert-St Louis to Panama City NW Florida Beaches flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on St. Louis to Panama City, Florida flights?

You could potentially save up to 9% on your flight if you consider stops on a St. Louis to Panama City, Florida flight.

How have St. Louis to Panama City, Florida flight prices changed over time?

As of April 2026, prices for St. Louis to Panama City, Florida flights are approximately 11% cheaper when compared to flights at the same time last year.

When to book flights from St. Louis to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Panama City, Florida (STL to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Panama City, Florida

Best Price Found

$357

Fastest flight time

1h 45m

Direct flights

Every day

Airports in Panama City, Florida

1 airport
The best flight deal from St. Louis to Panama City, Florida found on momondo in the last 72 hours is $357
The fastest flight from St. Louis to Panama City, Florida takes 1h 45m
Direct flights go from St. Louis to Panama City, Florida every day.
There is 1 airport in Panama City, Florida. From St. Louis there are direct flights to Panama City NW Florida Beaches (ECP).
Search flight deals

Frequently asked questions about flying from St. Louis to Panama City, Florida

  • How far is Lambert-St Louis to Panama City NW Florida Beaches by plane?

    The straight-line distance from Lambert-St Louis to Panama City NW Florida Beaches is 639.0 mi. 1h 45m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The necessary travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from St. Louis to Panama City, Florida?

  • What is the most popular airline from St. Louis to Panama City, Florida?

Best airlines flying from St. Louis to Panama City, Florida

Compare and see reviews for airlines that fly from St. Louis to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $176Free CancellationRating
7.9
8,392 reviews
Search Delta flights
American AirlinesPriceFrom $186Free CancellationRating
7.1
11,561 reviews
Search American Airlines flights
SouthwestPriceFrom $201Free CancellationRating
8.0
4,338 reviews
Search Southwest flights

  • Southwest Flights From St. Louis to Panama City, Florida

    The lowest priced Southwest flight from St. Louis to Panama City, Florida from the last 72 hours was $201. Generally, Southwest has 5 flights on this route every week with an average price of $422. Southwest is rated 8.0/10 by our users.

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Panama City?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Panama City. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Panama City with flexible booking policies on momondo?

Flights from St. Louis to Panama City with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from St. Louis to Panama City.

I’m not ready to book a flight from St. Louis to Panama City right now. Can momondo alert me if prices change?

Yes. momondo can track prices for St. Louis to Panama City flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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