Cheap flights from South Carolina to St. Louis from $84

In general, September is the cheapest month to fly from South Carolina to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $346. The month of February is another great option to travel to St. Louis, with average flight prices from South Carolina averaging around $346.

The cheapest day to depart on your flight to St. Louis is on a Wednesday when prices can be found for as low as $330. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $606. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

Flying to St. Louis from South Carolina in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $381 when looking at flights departing in the afternoon. At noon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $496 per ticket.

Fly from Charleston to Lambert-St Louis for the best South Carolina - Lambert-St Louis flight prices

There is only 1 cabin class available to choose from on South Carolina to St. Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

No. A direct flight is the cheapest option for a flight between South Carolina to St. Louis.

Southwest, Delta, and United Airlines are the most popular carriers operating from South Carolina to Lambert-St Louis

American Airlines, Delta and Southwest are the top three most popular airlines that fly to St. Louis from South Carolina according to our data. American Airlines is the first choice among our users, with 41% of people opting to fly with this airline when traveling to St. Louis. Keep in mind that there are 3 different airlines that fly to St. Louis on a routine basis, so you have a few additional options to choose from.

6 flights are operational weekly from South Carolina to St. Louis as of September 2026. The most popular departure day for this route is Mon, with 33% of flights per week taking off on this day.

Flight times from South Carolina to St. Louis vary, but if you’re flying out of Charleston and flying into St. Louis (one of the most popular routes), then the duration is 2h 05m on average. Another popular route from South Carolina to St. Louis is flying from Myrtle Beach to St. Louis, which will take roughly 4h. Keep in mind that layovers or delays could extend your travel time.