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Cheap flights from South Carolina to St. Louis from $67

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to St. Louis departing on 3/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from South Carolina to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
4:18 pm - 11:25 pm
CLT
-
STL
8h 07m
1 stop
Frontier Logo
8:41 am - 12:36 am
STL
-
CLT
14h 55m
1 stop
$160Frontier
Thu, Apr 9 - Mon, Apr 13
Frontier Logo
8:05 pm - 11:19 pm
CLT
-
STL
28h 14m
1 stop
Frontier Logo
4:55 pm - 2:41 pm
STL
-
CLT
20h 46m
1 stop
$171Frontier
Wed, Apr 29 - Wed, May 13
American Airlines Logo
5:10 am - 8:35 am
MYR
-
STL
4h 25m
1 stop
American Airlines Logo
6:06 am - 11:39 am
STL
-
MYR
4h 33m
1 stop
$189American Airlines
Sat, Feb 21 - Mon, Feb 23
American Airlines Logo
7:26 am - 8:30 am
CLT
-
STL
2h 04mnonstop
American Airlines Logo
7:00 am - 10:02 am
STL
-
CLT
2h 02mnonstop
$191American Airlines
Wed, Apr 29 - Wed, May 13
United Airlines Logo
3:15 pm - 9:08 pm
MYR
-
STL
6h 53m
1 stop
United Airlines Logo
7:45 am - 2:17 pm
STL
-
MYR
5h 32m
1 stop
$192United Airlines
Mon, Mar 30 - Mon, Apr 6
United Airlines Logo
5:03 pm - 9:08 pm
CHS
-
STL
5h 05m
1 stop
United Airlines Logo
7:45 am - 1:51 pm
STL
-
CHS
5h 06m
1 stop
$192United Airlines
Tue, May 5 - Tue, May 12
Delta Logo
3:57 pm - 11:14 pm
MYR
-
STL
8h 17m
1 stop
Delta Logo
4:41 pm - 12:14 am
STL
-
MYR
6h 33m
1 stop
$197Delta
Fri, Apr 17 - Mon, Apr 20
Delta Logo
5:35 am - 8:30 am
SAV
-
STL
3h 55m
1 stop
Delta Logo
6:50 pm - 11:59 pm
STL
-
SAV
4h 09m
1 stop
$197Delta
Fri, May 1 - Mon, May 4
Multiple Airlines Logo
3:16 pm - 6:50 am
CLT
-
STL
16h 34m
2 stops
Multiple Airlines Logo
8:12 pm - 6:54 pm
STL
-
CLT
21h 42m
1 stop
$199Multiple Airlines
Tue, Apr 28 - Sat, May 9
Multiple Airlines Logo
3:35 pm - 6:50 am
CHS
-
STL
16h 15m
2 stops
Multiple Airlines Logo
4:55 pm - 9:38 am
STL
-
CHS
15h 43m
1 stop
$260Multiple Airlines
Tue, May 5 - Tue, May 12

United Airlines flights from South Carolina to St. Louis

Our best United Airlines deals on South Carolina to St. Louis flight tickets
United Airlines
May 5
CHS5:03 pmCharleston
5h 05m
1 stop
STL9:08 pmLambert-St Louis
May 12
STL7:45 amLambert-St Louis
5h 06m
1 stop
CHS1:51 pmCharleston
$192
United Airlines
Jul 14
CLT10:24 amCharlotte Douglas
6h 22m
1 stop
STL3:46 pmLambert-St Louis
Jul 18
STL1:13 pmLambert-St Louis
7h 16m
1 stop
CLT9:29 pmCharlotte Douglas
$201
United Airlines
Feb 27
CHS5:05 pmCharleston
5h 35m
1 stop
STL9:40 pmLambert-St Louis
Mar 2
STL6:25 amLambert-St Louis
5h 05m
1 stop
CHS12:30 pmCharleston
$205

Delta flights from South Carolina to St. Louis

Our best Delta deals on South Carolina to St. Louis flight tickets
Delta
May 1
SAV5:35 amSavannah/Hilton Head
3h 55m
1 stop
STL8:30 amLambert-St Louis
May 4
STL6:50 pmLambert-St Louis
4h 09m
1 stop
SAV11:59 pmSavannah/Hilton Head
$197
Delta
Feb 21
MYR6:00 amMyrtle Beach Intl
4h 06m
1 stop
STL9:06 amLambert-St Louis
Feb 23
STL6:47 pmLambert-St Louis
4h 10m
1 stop
MYR11:57 pmMyrtle Beach Intl
$205
Delta
Jun 18
CHS7:10 amCharleston
7h 07m
1 stop
STL1:17 pmLambert-St Louis
Jun 23
STL3:42 pmLambert-St Louis
5h 03m
1 stop
CHS9:45 pmCharleston
$207

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 9, 2026.
Use the filters below to find and compare flights from South Carolina to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Thu 4/9

4:18 pm-11:25 pm

1 stop8h 07m

Lambert-St Louis

Mon 4/13

8:41 am-12:36 am

1 stop14h 55m

$160

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Wed 4/29

8:05 pm-11:19 pm

1 stop28h 14m

Lambert-St Louis

Wed 5/13

4:55 pm-2:41 pm

1 stop20h 46m

$171

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Sat 2/21

5:10 am-8:35 am

1 stop4h 25m

Lambert-St Louis

Mon 2/23

6:06 am-11:39 am

1 stop4h 33m

$189

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Wed 4/29

7:26 am-8:30 am

Nonstop2h 04m

Lambert-St Louis

Wed 5/13

7:00 am-10:02 am

Nonstop2h 02m

$191

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Mon 3/30

3:15 pm-9:08 pm

1 stop6h 53m

Lambert-St Louis

Mon 4/6

7:45 am-2:17 pm

1 stop5h 32m

$192

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

Tue 5/5

5:03 pm-9:08 pm

1 stop5h 05m

Lambert-St Louis

Tue 5/12

7:45 am-1:51 pm

1 stop5h 06m

$192

Myrtle BeachSt. Louis

MYR - STL

MYRSTL

Myrtle Beach Intl

Fri 4/17

3:57 pm-11:14 pm

1 stop8h 17m

Lambert-St Louis

Mon 4/20

4:41 pm-12:14 am

1 stop6h 33m

$197

SavannahSt. Louis

SAV - STL

SAVSTL

Savannah/Hilton Head

Fri 5/1

5:35 am-8:30 am

1 stop3h 55m

Lambert-St Louis

Mon 5/4

6:50 pm-11:59 pm

1 stop4h 09m

$197

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Tue 4/28

3:16 pm-6:50 am

2 stops16h 34m

Lambert-St Louis

Sat 5/9

8:12 pm-6:54 pm

1 stop21h 42m

$199

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

Tue 5/5

3:35 pm-6:50 am

2 stops16h 15m

Lambert-St Louis

Tue 5/12

4:55 pm-9:38 am

1 stop15h 43m

$260

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from South Carolina to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, September is the cheapest month to fly from South Carolina to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $308. The month of August is another great option to travel to St. Louis, with average flight prices from South Carolina averaging around $342.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Thursday when prices can be found for as low as $336. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $631. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from South Carolina in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $388 when looking at flights departing in the afternoon. At noon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $606 per ticket.

What is the cheapest South Carolina to Lambert-St Louis flight route?

Fly from Charleston to Lambert-St Louis for the best South Carolina - Lambert-St Louis flight prices

What cabin class options are available on South Carolina to Lambert-St Louis flights?

There is only 1 cabin class available to choose from on South Carolina to Lambert-St Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on South Carolina to St. Louis flights?

You could potentially save up to 31% on your flight if you consider stops on a South Carolina to St. Louis flight.

Cheap South Carolina to St. Louis flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to St. Louis

Best Price Found

$376

Fastest flight time

2h 00m

Direct flights

Every day

Airports in St. Louis

1 airport
The best flight deal from South Carolina to St. Louis found on momondo in the last 72 hours is $376
The fastest flight from South Carolina to St. Louis takes 2h 00m
Direct flights go from South Carolina to St. Louis every day.
There is 1 airport in St. Louis. From South Carolina there are direct flights to Lambert-St Louis (STL).
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Lambert-St Louis Airport?

    Prices for flights from South Carolina to Lambert-St Louis Airport were last updated today.

  • How many operators does momondo search for flights from South Carolina to Lambert-St Louis Airport?

  • How old do you have to be to fly from South Carolina to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The required travel and health documents for your Lambert-St Louis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lambert-St Louis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from South Carolina to St. Louis?

Best airlines flying from South Carolina to St. Louis

Compare and see reviews for airlines that fly from South Carolina to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $128Free CancellationRating
7.9
8,178 reviews
Search Delta flights
American AirlinesPriceFrom $229Free CancellationRating
7.2
11,259 reviews
Search American Airlines flights
SouthwestPriceFrom $287Free CancellationRating
8.0
4,280 reviews
Search Southwest flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
Florissant
O'Fallon
Collinsville
St. Peters
Fenton
Wentzville
Alton
Farmington
Clayton
Edwardsville
Eureka
Festus
Litchfield
Glencoe
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to St. Louis?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from South Carolina to St. Louis. momondo saves you time and could save you money on your trip.

Can I find flights from South Carolina to St. Louis with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to St. Louis flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to St. Louis?

Once all potential South Carolina to St. Louis flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from South Carolina to St. Louis right now. Can momondo alert me if prices change?

Price alerts on flights to St. Louis from South Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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