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Cheap flights from South Carolina to St. Louis from $101

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to St. Louis departing on 6/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from South Carolina to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
10:14 pm - 6:53 pm
CLT
-
STL
21h 39m
1 stop
Frontier Logo
8:08 pm - 6:18 pm
STL
-
CLT
21h 10m
1 stop
$199Frontier
Wed, Jul 1 - Wed, Jul 8
Frontier Logo
12:29 pm - 11:49 pm
CLT
-
STL
12h 20m
1 stop
Frontier Logo
4:17 pm - 11:34 am
STL
-
CLT
18h 17m
1 stop
$200Frontier
Wed, Jun 24 - Wed, Jul 1
Southwest Logo
1:25 pm - 2:25 pm
CLT
-
STL
2h 00mnonstop
Southwest Logo
4:50 pm - 7:40 pm
STL
-
CLT
1h 50mnonstop
$217Southwest
Wed, Jun 24 - Wed, Jul 1
Multiple Airlines Logo
8:25 am - 11:59 pm
GSP
-
STL
16h 34m
1 stop
Multiple Airlines Logo
4:52 pm - 7:56 pm
STL
-
GSP
26h 04m
2 stops
$221Multiple Airlines
Thu, Jul 9 - Wed, Jul 15
Multiple Airlines Logo
8:25 am - 11:59 pm
GSP
-
STL
16h 34m
1 stop
Multiple Airlines Logo
6:33 pm - 7:35 am
STL
-
GSP
36h 02m
2 stops
$226Multiple Airlines
Thu, Jul 9 - Tue, Jul 14
Southwest Logo
1:50 pm - 3:00 pm
CHS
-
STL
2h 10mnonstop
Southwest Logo
3:15 pm - 6:15 pm
STL
-
CHS
2h 00mnonstop
$237Southwest
Tue, Jul 14 - Wed, Jul 22
United Airlines Logo
11:31 am - 3:46 pm
CHS
-
STL
5h 15m
1 stop
United Airlines Logo
1:13 pm - 9:48 pm
STL
-
CHS
7h 35m
1 stop
$257United Airlines
Tue, Jul 14 - Wed, Jul 22
American Airlines Logo
8:04 pm - 12:16 am
CHS
-
STL
5h 12m
1 stop
American Airlines Logo
6:13 pm - 11:59 pm
STL
-
CHS
4h 46m
1 stop
$285American Airlines
Thu, Jun 4 - Mon, Jun 8
American Airlines Logo
5:50 am - 10:12 am
CAE
-
STL
5h 22m
1 stop
American Airlines Logo
6:00 am - 3:25 pm
STL
-
CAE
8h 25m
1 stop
$306American Airlines
Tue, Jun 9 - Tue, Jun 16
United Airlines Logo
10:35 am - 3:46 pm
CAE
-
STL
6h 11m
1 stop
United Airlines Logo
1:13 pm - 9:16 pm
STL
-
CAE
7h 03m
1 stop
$348United Airlines
Tue, May 26 - Sat, May 30

Frontier flights from South Carolina to St. Louis

Our best Frontier deals on South Carolina to St. Louis flight tickets
Frontier
Jul 1
CLT10:14 pmCharlotte Douglas
21h 39m
1 stop
STL6:53 pmLambert-St Louis
Jul 8
STL8:08 pmLambert-St Louis
21h 10m
1 stop
CLT6:18 pmCharlotte Douglas
$199
Frontier
Jun 24
CLT12:29 pmCharlotte Douglas
12h 20m
1 stop
STL11:49 pmLambert-St Louis
Jul 1
STL4:17 pmLambert-St Louis
18h 17m
1 stop
CLT11:34 amCharlotte Douglas
$200
Frontier
Jul 14
CLT7:14 pmCharlotte Douglas
25h 09m
1 stop
STL7:23 pmLambert-St Louis
Jul 21
STL4:09 pmLambert-St Louis
23h 26m
1 stop
CLT4:35 pmCharlotte Douglas
$201

Southwest flights from South Carolina to St. Louis

Our best Southwest deals on South Carolina to St. Louis flight tickets
Southwest
Jun 24
CLT1:25 pmCharlotte Douglas
2h 00m
STL2:25 pmLambert-St Louis
Jul 1
STL4:50 pmLambert-St Louis
1h 50m
CLT7:40 pmCharlotte Douglas
$217
Southwest
Jul 1
CLT1:25 pmCharlotte Douglas
2h 00m
STL2:25 pmLambert-St Louis
Jul 8
STL9:40 amLambert-St Louis
5h 00m
1 stop
CLT3:40 pmCharlotte Douglas
$227
Southwest
Aug 17
CLT11:50 amCharlotte Douglas
1h 55m
STL12:45 pmLambert-St Louis
Oct 21
STL3:00 pmLambert-St Louis
1h 50m
CLT5:50 pmCharlotte Douglas
$228

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 15, 2026.
Use the filters below to find and compare flights from South Carolina to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Wed 7/1

10:14 pm-6:53 pm

1 stop21h 39m

Lambert-St Louis

Wed 7/8

8:08 pm-6:18 pm

1 stop21h 10m

$199

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Wed 6/24

12:29 pm-11:49 pm

1 stop12h 20m

Lambert-St Louis

Wed 7/1

4:17 pm-11:34 am

1 stop18h 17m

$200
Quickest round-trip

CharlotteSt. Louis

CLT - STL

CLTSTL

Charlotte Douglas

Wed 6/24

1:25 pm-2:25 pm

Nonstop2h 00m

Lambert-St Louis

Wed 7/1

4:50 pm-7:40 pm

Nonstop1h 50m

$217

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Thu 7/9

8:25 am-11:59 pm

1 stop16h 34m

Lambert-St Louis

Wed 7/15

4:52 pm-7:56 pm

2 stops26h 04m

$221

GreenvilleSt. Louis

GSP - STL

GSPSTL

Greenville

Thu 7/9

8:25 am-11:59 pm

1 stop16h 34m

Lambert-St Louis

Tue 7/14

6:33 pm-7:35 am

2 stops36h 02m

$226

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

Tue 7/14

1:50 pm-3:00 pm

Nonstop2h 10m

Lambert-St Louis

Wed 7/22

3:15 pm-6:15 pm

Nonstop2h 00m

$237

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

Tue 7/14

11:31 am-3:46 pm

1 stop5h 15m

Lambert-St Louis

Wed 7/22

1:13 pm-9:48 pm

1 stop7h 35m

$257

CharlestonSt. Louis

CHS - STL

CHSSTL

Charleston

Thu 6/4

8:04 pm-12:16 am

1 stop5h 12m

Lambert-St Louis

Mon 6/8

6:13 pm-11:59 pm

1 stop4h 46m

$285

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

Tue 6/9

5:50 am-10:12 am

1 stop5h 22m

Lambert-St Louis

Tue 6/16

6:00 am-3:25 pm

1 stop8h 25m

$306

ColumbiaSt. Louis

CAE - STL

CAESTL

Columbia Metropolitan

Tue 5/26

10:35 am-3:46 pm

1 stop6h 11m

Lambert-St Louis

Sat 5/30

1:13 pm-9:16 pm

1 stop7h 03m

$348

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from South Carolina to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, June is the cheapest month to fly from South Carolina to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $108. The month of October is another great option to travel to St. Louis, with average flight prices from South Carolina averaging around $158.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Thursday when prices can be found for as low as $287. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $606. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from South Carolina in the morning is the least expensive time of day to depart. momondo users have found prices as low as $357 when looking at flights departing in the morning. At noon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $538 per ticket.

What is the cheapest South Carolina to Lambert-St Louis flight route?

Fly from Charleston to Lambert-St Louis for the best South Carolina - Lambert-St Louis flight prices

Cheap South Carolina to St. Louis flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to St. Louis

Best Price Found

$219

Fastest flight time

1h 55m

Direct flights

Every day

Airports in St. Louis

1 airport
The best one-way flight to St. Louis from South Carolina in the past 72 hours is $219. The best round-trip flight deal from South Carolina to St. Louis found on momondo in the last 72 hours is $388.
The fastest flight from South Carolina to St. Louis takes 1h 55m
Direct flights go from South Carolina to St. Louis every day.
There is 1 airport in St. Louis. From South Carolina there are direct flights to Lambert-St Louis (STL).
Search flight deals

Frequently asked questions about flying from South Carolina to St. Louis

  • When did momondo last update prices for flights from South Carolina to Lambert-St Louis Airport?

    Prices for flights from South Carolina to Lambert-St Louis Airport were last updated today.

  • How many operators does momondo search for flights from South Carolina to Lambert-St Louis Airport?

  • How old do you have to be to fly from South Carolina to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The required travel and health documents for your Lambert-St Louis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lambert-St Louis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from South Carolina to St. Louis?

Best airlines flying from South Carolina to St. Louis

Compare and see reviews for airlines that fly from South Carolina to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $128Free CancellationRating
7.9
8,453 reviews
Search Delta flights
American AirlinesPriceFrom $229Free CancellationRating
7.1
11,662 reviews
Search American Airlines flights
SouthwestPriceFrom $281Free CancellationRating
8.0
4,299 reviews
Search Southwest flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
O'Fallon
Florissant
St. Peters
Collinsville
Alton
Wentzville
Fenton
Farmington
Festus
Clayton
Eureka
Litchfield
Edwardsville
Shrewsbury
Grafton

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to St. Louis?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from South Carolina to St. Louis. momondo saves you time and could save you money on your trip.

Can I find flights from South Carolina to St. Louis with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to St. Louis flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to St. Louis?

Once all potential South Carolina to St. Louis flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from South Carolina to St. Louis right now. Can momondo alert me if prices change?

Price alerts on flights to St. Louis from South Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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