Cheap flights from South Carolina to St. Louis from $99

In general, October is the cheapest month to fly from South Carolina to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $158. The month of April is another great option to travel to St. Louis, with average flight prices from South Carolina averaging around $183.

The cheapest day to depart on your flight to St. Louis is on a Wednesday when prices can be found for as low as $336. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $606. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

Flying to St. Louis from South Carolina in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $381 when looking at flights departing in the afternoon. At noon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $527 per ticket.

Fly from Charleston to Lambert-St Louis for the best South Carolina - Lambert-St Louis flight prices

There is only 1 cabin class available to choose from on South Carolina to St. Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

No. A direct flight is the cheapest option for a flight between South Carolina to St. Louis.

Southwest, Frontier, and Delta are the most popular carriers operating from South Carolina to Lambert-St Louis

Delta, American Airlines and Southwest are the top three most popular airlines that fly to St. Louis from South Carolina according to our data. Delta is the first choice among our users, with 44% of people opting to fly with this airline when traveling to St. Louis. Keep in mind that there are 3 different airlines that fly to St. Louis on a routine basis, so you have a few additional options to choose from.

As of June 2026, there are 8 flights per day flying from South Carolina to St. Louis. The most common time of day flights depart is 4:00PM, with 88% of flights taking off in the afternoon.

58 flights are operational weekly from South Carolina to St. Louis as of June 2026. The most popular departure day for this route is Mon, with 22% of flights per week taking off on this day.