Cheap flights from South Carolina to Indianapolis from $49

In general, July is the cheapest month to fly from South Carolina to Indianapolis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $45. If you are unable to visit Indianapolis during the month of July, then departing from South Carolina during the month June is also very affordable. Most momondo users find prices during this month for around $49.

Flying to Indianapolis from South Carolina in the evening is the least expensive time of day to depart. momondo users have found prices as low as $113 when looking at flights departing in the evening. If you have a flexible travel schedule, then try to avoid flying in the afternoon when prices are $149 on average. Flights to Indianapolis from South Carolina in the afternoon are generally more expensive because this time of day is more convenient for travelers’ schedules.

Fly from Charleston to Indianapolis for the best South Carolina - Indianapolis flight prices

You are more likely to see cheaper flights to Indianapolis from South Carolina when booking weeks ahead of your departure date. In general, you can expect to find flights to Indianapolis for around $339 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Indianapolis from South Carolina for as low as $133 on momondo.

No. A direct flight is the cheapest option for a flight between South Carolina to Indianapolis.

Allegiant Air, Delta, and United Airlines are the most popular carriers operating from South Carolina to Indianapolis

American Airlines, Delta and Allegiant Air are the top three most popular airlines that fly to Indianapolis from South Carolina according to our data. American Airlines is the first choice among our users, with 43% of people opting to fly with this airline when traveling to Indianapolis. Keep in mind that there are 7 different airlines that fly to Indianapolis on a routine basis, so you have a few additional options to choose from.

As of May 2026, 38 flights take off from South Carolina and land in Indianapolis each week. The most common flight departure day for this route is Wed, with 21% of weekly flights taking off on this day.

Flight times from South Carolina to Indianapolis vary, but if you’re flying out of Myrtle Beach and flying into Indianapolis (one of the most popular routes), then the duration is 1h 46m on average. Another popular route from South Carolina to Indianapolis is flying from Charleston to Indianapolis, which will take roughly 1h 54m. Keep in mind that layovers or delays could extend your travel time.