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Cheap flights from South Carolina to Indianapolis from $86

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Indianapolis departing on 9/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from South Carolina to Indianapolis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
3:13 pm - 6:38 pmCHS  Charleston-IND Indianapolis
27h 25m1 stop Orlando
Multiple Airlines Logo
7:33 pm - 8:38 amIND  Indianapolis-CHS Charleston
13h 05m1 stop Orlando
$166Multiple Airlines
Tue, Sep 1 - Tue, Sep 8
Frontier Logo
8:56 am - 6:38 pmCLT  Charlotte Douglas-IND Indianapolis
9h 42m1 stop Orlando
Frontier Logo
11:21 am - 8:35 amIND  Indianapolis-CLT Charlotte Douglas
21h 14m1 stop Orlando
$176Frontier
Tue, Sep 1 - Tue, Sep 15
Multiple Airlines Logo
3:42 pm - 6:46 pmCHS  Charleston-IND Indianapolis
27h 04m1 stop Orlando
Multiple Airlines Logo
11:21 am - 8:38 amIND  Indianapolis-CHS Charleston
21h 17m1 stop Orlando
$179Multiple Airlines
Wed, Sep 9 - Tue, Sep 15
Frontier Logo
9:52 pm - 10:25 amCLT  Charlotte Douglas-IND Indianapolis
12h 33m1 stop Orlando
Frontier Logo
9:20 pm - 3:16 pmIND  Indianapolis-CLT Charlotte Douglas
17h 56m1 stop Orlando
$181Frontier
Tue, Sep 8 - Mon, Sep 14
Delta Logo
2:00 pm - 5:47 pmGSP  Greenville-IND Indianapolis
3h 47m1 stop Atlanta Hartsfield-Jackson
Delta Logo
8:00 am - 1:05 pmIND  Indianapolis-GSP Greenville
5h 05m1 stop Atlanta Hartsfield-Jackson
$233Delta
Sat, Oct 24 - Tue, Oct 27
Delta Logo
7:00 am - 10:25 amGSP  Greenville-IND Indianapolis
3h 25m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:00 pm - 9:51 pmIND  Indianapolis-GSP Greenville
4h 51m1 stop Atlanta Hartsfield-Jackson
$233Delta
Sat, Oct 17 - Mon, Oct 19
American Airlines Logo
7:41 pm - 11:41 pmGSP  Greenville-IND Indianapolis
4h 00m1 stop Charlotte Douglas
American Airlines Logo
6:50 am - 11:03 amIND  Indianapolis-GSP Greenville
4h 13m1 stop Chicago O'Hare Intl
$233American Airlines
Mon, Sep 14 - Thu, Sep 17
Southwest Logo
6:40 am - 3:05 pmGSP  Greenville-IND Indianapolis
8h 25m2 stops Nashville Intl Dallas Love Field
Southwest Logo
4:05 pm - 8:00 pmIND  Indianapolis-GSP Greenville
3h 55m1 stop Baltimore/Washington
$239Southwest
Sat, Oct 24 - Tue, Oct 27
Southwest Logo
5:35 pm - 10:15 pmCHS  Charleston-IND Indianapolis
4h 40m1 stop Baltimore/Washington
Southwest Logo
5:30 am - 10:20 amIND  Indianapolis-CHS Charleston
4h 50m1 stop Baltimore/Washington
$240Southwest
Sat, Nov 7 - Mon, Nov 9
American Airlines Logo
3:33 pm - 9:30 pmSAV  Savannah/Hilton Head-IND Indianapolis
5h 57m1 stop Washington, D.C. Reagan-National
American Airlines Logo
10:51 am - 3:40 pmIND  Indianapolis-SAV Savannah/Hilton Head
4h 49m1 stop Charlotte Douglas
$263American Airlines
Wed, Sep 9 - Wed, Sep 16

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Delta flights from South Carolina to Indianapolis

Our best Delta deals on South Carolina to Indianapolis flight tickets
Delta
Sep 8
GSP5:45 amGreenville
5h 59m
1 stop
IND11:44 amIndianapolis
Sep 11
IND6:00 amIndianapolis
3h 25m
1 stop
GSP9:25 amGreenville
$268
Delta
Sep 12
CAE6:00 amColumbia Metropolitan
4h 26m
1 stop
IND10:26 amIndianapolis
Sep 14
IND4:43 pmIndianapolis
4h 28m
1 stop
CAE9:11 pmColumbia Metropolitan
$296
Delta
Aug 29
CAE6:11 amColumbia Metropolitan
4h 15m
1 stop
IND10:26 amIndianapolis
Sep 1
IND7:02 amIndianapolis
6h 12m
1 stop
CAE1:14 pmColumbia Metropolitan
$299

Frontier flights from South Carolina to Indianapolis

Our best Frontier deals on South Carolina to Indianapolis flight tickets
Frontier
Sep 1
CLT8:56 amCharlotte Douglas
9h 42m
1 stop
IND6:38 pmIndianapolis
Sep 15
IND11:21 amIndianapolis
21h 14m
1 stop
CLT8:35 amCharlotte Douglas
$176
Frontier
Sep 8
CLT9:52 pmCharlotte Douglas
12h 33m
1 stop
IND10:25 amIndianapolis
Sep 16
IND11:21 amIndianapolis
21h 14m
1 stop
CLT8:35 amCharlotte Douglas
$181
Frontier
Sep 23
CLT9:40 pmCharlotte Douglas
11h 51m
1 stop
IND9:31 amIndianapolis
Sep 29
IND11:21 amIndianapolis
27h 55m
1 stop
CLT3:16 pmCharlotte Douglas
$182

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Indianapolis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 11, 2026.
Use the filters below to find and compare flights from South Carolina to Indianapolis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonIndianapolis

CHS Charleston - IND Indianapolis

CHSIND

Charleston

Tue 9/1

3:13 pm-6:38 pm

1 stop27h 25m

Indianapolis

Tue 9/8

7:33 pm-8:38 am

1 stop13h 05m

$166

CharlotteIndianapolis

CLT Charlotte Douglas - IND Indianapolis

CLTIND

Charlotte Douglas

Tue 9/1

8:56 am-6:38 pm

1 stop9h 42m

Indianapolis

Tue 9/15

11:21 am-8:35 am

1 stop21h 14m

$176

CharlestonIndianapolis

CHS Charleston - IND Indianapolis

CHSIND

Charleston

Wed 9/9

3:42 pm-6:46 pm

1 stop27h 04m

Indianapolis

Tue 9/15

11:21 am-8:38 am

1 stop21h 17m

$179

CharlotteIndianapolis

CLT Charlotte Douglas - IND Indianapolis

CLTIND

Charlotte Douglas

Tue 9/8

9:52 pm-10:25 am

1 stop12h 33m

Indianapolis

Mon 9/14

9:20 pm-3:16 pm

1 stop17h 56m

$181

GreenvilleIndianapolis

GSP Greenville - IND Indianapolis

GSPIND

Greenville

Sat 10/24

2:00 pm-5:47 pm

1 stop3h 47m

Indianapolis

Tue 10/27

8:00 am-1:05 pm

1 stop5h 05m

$233

GreenvilleIndianapolis

GSP Greenville - IND Indianapolis

GSPIND

Greenville

Sat 10/17

7:00 am-10:25 am

1 stop3h 25m

Indianapolis

Mon 10/19

5:00 pm-9:51 pm

1 stop4h 51m

$233
Quickest round-trip

GreenvilleIndianapolis

GSP Greenville - IND Indianapolis

GSPIND

Greenville

Mon 9/14

7:41 pm-11:41 pm

1 stop4h 00m

Indianapolis

Thu 9/17

6:50 am-11:03 am

1 stop4h 13m

$233

GreenvilleIndianapolis

GSP Greenville - IND Indianapolis

GSPIND

Greenville

Sat 10/24

6:40 am-3:05 pm

2 stops8h 25m

Indianapolis

Tue 10/27

4:05 pm-8:00 pm

1 stop3h 55m

$239

CharlestonIndianapolis

CHS Charleston - IND Indianapolis

CHSIND

Charleston

Sat 11/7

5:35 pm-10:15 pm

1 stop4h 40m

Indianapolis

Mon 11/9

5:30 am-10:20 am

1 stop4h 50m

$240

SavannahIndianapolis

SAV Savannah/Hilton Head - IND Indianapolis

SAVIND

Savannah/Hilton Head

Wed 9/9

3:33 pm-9:30 pm

1 stop5h 57m

Indianapolis

Wed 9/16

10:51 am-3:40 pm

1 stop4h 49m

$263

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Indianapolis from

How to get the cheapest flight ticket from South Carolina to Indianapolis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Indianapolis?

In general, January is the cheapest month to fly from South Carolina to Indianapolis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $308. If you are unable to visit Indianapolis during the month of January, then departing from South Carolina during the month July is also very affordable. Most momondo users find prices during this month for around $342.

What is the cheapest day to depart on your flight to Indianapolis?

Our data shows that Friday is the least expensive day to fly to Indianapolis. Tickets to fly out on this day can be as low as $138. Be sure to avoid booking your departure on a Saturday as prices are generally higher than usual. According to our data, the average ticket price to Indianapolis on Saturday is $154.

What is the cheapest South Carolina to Indianapolis flight route?

Fly from Myrtle Beach Intl to Indianapolis for the best South Carolina - Indianapolis flight prices

What cabin class options are available on South Carolina to Indianapolis flights?

There is only 1 cabin class available to choose from on South Carolina to Indianapolis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on South Carolina to Indianapolis flights?

No. A direct flight is the cheapest option for a flight between South Carolina to Indianapolis.

Cheap South Carolina to Indianapolis flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Indianapolis

Best Price Found

$107

Fastest flight time

1h 36m

Direct flights

Every day

Airports in Indianapolis

1 airport
The best one-way flight to Indianapolis from South Carolina in the past 72 hours is $107. The best round-trip flight deal from South Carolina to Indianapolis found on momondo in the last 72 hours is $96.
The fastest flight from South Carolina to Indianapolis takes 1h 36m
Direct flights go from South Carolina to Indianapolis every day.
There is 1 airport in Indianapolis. From South Carolina there are direct flights to Indianapolis (IND).
Search flight deals

Frequently asked questions about flying from South Carolina to Indianapolis

  • When did momondo last update prices for flights from South Carolina to Indianapolis Airport?

    Prices for flights from South Carolina to Indianapolis Airport refresh daily.

  • How many operators does momondo search for flights from South Carolina to Indianapolis Airport?

  • How old do you have to be to fly from South Carolina to Indianapolis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from South Carolina to Indianapolis Airport.

  • What documentation or ID do you need to fly to Indianapolis Airport?

    The required travel and health documents for your Indianapolis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Indianapolis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from South Carolina to Indianapolis?

Best airlines flying from South Carolina to Indianapolis

Compare and see reviews for airlines that fly from South Carolina to Indianapolis with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $76Free CancellationRating
7.3
679 reviews
Search Allegiant Air flights
DeltaPriceFrom $183Free CancellationRating
7.8
8,506 reviews
Search Delta flights
SouthwestPriceFrom $189Free CancellationRating
8.0
4,218 reviews
Search Southwest flights
United AirlinesPriceFrom $190Free CancellationRating
7.4
10,102 reviews
Search United Airlines flights
American AirlinesPriceFrom $273Free CancellationRating
7.1
11,902 reviews
Search American Airlines flights

Traveling to a place near Indianapolis?

Book flights to Indianapolis if you plan to visit one of these locations
Terre Haute
Bloomington
Kokomo
Muncie
Greenwood
Anderson
Plainfield
Noblesville
Carmel
West Lafayette
Speedway
Fishers
Franklin
Westfield
Seymour
Shelbyville
Brownsburg
Crawfordsville
Greenfield
Mooresville

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Indianapolis?

It is quick and easy to find South Carolina to Indianapolis flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Indianapolis that suits you.

Can I find flights from South Carolina to Indianapolis with flexible booking policies on momondo?

Yes. All flights to Indianapolis from South Carolina on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from South Carolina to Indianapolis?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Indianapolis from South Carolina.

I’m not ready to book a flight from South Carolina to Indianapolis right now. Can momondo alert me if prices change?

Yes. momondo can track prices for South Carolina to Indianapolis flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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