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Cheap flights from South Carolina to Buffalo from $80

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Buffalo departing on 9/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from South Carolina to Buffalo

Cheap round-trip flights

American Airlines Logo
6:29 pm - 12:12 amSAV-BUF
5h 43m1 stop
American Airlines Logo
7:40 am - 1:22 pmBUF-SAV
5h 42m1 stop
$159American Airlines
Find Deal
Thu, Sep 11 - Mon, Sep 15
American Airlines Logo
10:57 am - 5:01 pmCHS-BUF
6h 04m1 stop
American Airlines Logo
7:50 am - 12:43 pmBUF-CHS
4h 53m1 stop
$161American Airlines
Find Deal
Wed, Sep 3 - Sat, Sep 6
Southwest Logo
6:30 am - 12:30 pmMYR-BUF
6h 00m1 stop
Southwest Logo
4:05 pm - 7:45 pmBUF-MYR
3h 40m1 stop
$171Southwest
Find Deal
Tue, Sep 9 - Tue, Sep 9
JetBlue Logo
11:10 am - 7:04 pmCHS-BUF
7h 54m1 stop
JetBlue Logo
6:00 am - 10:25 amBUF-CHS
4h 25m1 stop
$181JetBlue
Find Deal
Sat, Sep 6 - Tue, Sep 9
Southwest Logo
6:30 am - 12:30 pmCLT-BUF
6h 00m1 stop
Southwest Logo
9:45 am - 3:15 pmBUF-CLT
5h 30m1 stop
$184Southwest
Find Deal
Wed, Sep 10 - Sat, Sep 13
Frontier Logo
9:37 pm - 4:16 pmCLT-BUF
18h 39m1 stop
Frontier Logo
7:05 pm - 8:46 pmBUF-CLT
25h 41m1 stop
$185Frontier
Find Deal
Sat, Aug 16 - Sat, Aug 23
Frontier Logo
9:41 pm - 10:17 amCLT-BUF
12h 36m1 stop
Frontier Logo
11:12 am - 8:46 pmBUF-CLT
9h 34m1 stop
$188Frontier
Find Deal
Sat, Aug 23 - Sun, Aug 31
JetBlue Logo
12:54 pm - 9:00 pmCHS-BUF
8h 06m1 stop
JetBlue Logo
6:00 am - 10:25 amBUF-CHS
4h 25m1 stop
$192JetBlue
Find Deal
Thu, Sep 4 - Tue, Sep 9
Delta Logo
5:20 pm - 10:36 pmCLT-BUF
5h 16m1 stop
Delta Logo
7:00 am - 1:23 pmBUF-CLT
6h 23m1 stop
$197Delta
Find Deal
Sat, Oct 4 - Tue, Oct 7
Delta Logo
7:37 pm - 12:53 amCLT-BUF
5h 16m1 stop
Delta Logo
6:04 am - 12:27 pmBUF-CLT
6h 23m1 stop
$212Delta
Find Deal
Fri, Sep 5 - Tue, Sep 9

Southwest flights from South Carolina to Buffalo

Our best Southwest deals on South Carolina to Buffalo flight tickets
Southwest
Sep 9
MYR6:30 amMyrtle Beach Intl
6h 00m
1 stop
BUF12:30 pmBuffalo
Sep 9
BUF4:05 pmBuffalo
3h 40m
1 stop
MYR7:45 pmMyrtle Beach Intl
$171
Find similar
Southwest
Oct 3
SAV7:45 pmSavannah/Hilton Head
4h 05m
1 stop
BUF11:50 pmBuffalo
Oct 13
BUF5:45 amBuffalo
4h 15m
1 stop
SAV10:00 amSavannah/Hilton Head
$184
Find similar
Southwest
Oct 9
CHS2:40 pmCharleston
6h 05m
1 stop
BUF8:45 pmBuffalo
Oct 13
BUF5:45 amBuffalo
4h 05m
1 stop
CHS9:50 amCharleston
$195
Find similar

JetBlue flights from South Carolina to Buffalo

Our best JetBlue deals on South Carolina to Buffalo flight tickets
JetBlue
Sep 6
CHS11:10 amCharleston
7h 54m
1 stop
BUF7:04 pmBuffalo
Sep 9
BUF6:00 amBuffalo
4h 25m
1 stop
CHS10:25 amCharleston
$181
Find similar
JetBlue
Sep 4
CHS12:54 pmCharleston
8h 06m
1 stop
BUF9:00 pmBuffalo
Sep 9
BUF6:00 amBuffalo
4h 25m
1 stop
CHS10:25 amCharleston
$192
Find similar
JetBlue
Sep 23
CHS11:10 amCharleston
7h 54m
1 stop
BUF7:04 pmBuffalo
Sep 30
BUF6:00 amBuffalo
4h 25m
1 stop
CHS10:25 amCharleston
$199
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 6, 2025.
Use the filters below to find and compare flights from South Carolina to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SavannahBuffalo

SAV - BUF

SAVBUF

Savannah/Hilton Head

Thu 9/11

6:29 pm-12:12 am

1 stop5h 43m

Buffalo

Mon 9/15

7:40 am-1:22 pm

1 stop5h 42m

$159

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Wed 9/3

10:57 am-5:01 pm

1 stop6h 04m

Buffalo

Sat 9/6

7:50 am-12:43 pm

1 stop4h 53m

$161

Myrtle BeachBuffalo

MYR - BUF

MYRBUF

Myrtle Beach Intl

Tue 9/9

6:30 am-12:30 pm

1 stop6h 00m

Buffalo

Tue 9/9

4:05 pm-7:45 pm

1 stop3h 40m

$171

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Sat 9/6

11:10 am-7:04 pm

1 stop7h 54m

Buffalo

Tue 9/9

6:00 am-10:25 am

1 stop4h 25m

$181

CharlotteBuffalo

CLT - BUF

CLTBUF

Charlotte Douglas

Wed 9/10

6:30 am-12:30 pm

1 stop6h 00m

Buffalo

Sat 9/13

9:45 am-3:15 pm

1 stop5h 30m

$184

CharlotteBuffalo

CLT - BUF

CLTBUF

Charlotte Douglas

Sat 8/16

9:37 pm-4:16 pm

1 stop18h 39m

Buffalo

Sat 8/23

7:05 pm-8:46 pm

1 stop25h 41m

$185

CharlotteBuffalo

CLT - BUF

CLTBUF

Charlotte Douglas

Sat 8/23

9:41 pm-10:17 am

1 stop12h 36m

Buffalo

Sun 8/31

11:12 am-8:46 pm

1 stop9h 34m

$188

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Thu 9/4

12:54 pm-9:00 pm

1 stop8h 06m

Buffalo

Tue 9/9

6:00 am-10:25 am

1 stop4h 25m

$192

CharlotteBuffalo

CLT - BUF

CLTBUF

Charlotte Douglas

Sat 10/4

5:20 pm-10:36 pm

1 stop5h 16m

Buffalo

Tue 10/7

7:00 am-1:23 pm

1 stop6h 23m

$197

CharlotteBuffalo

CLT - BUF

CLTBUF

Charlotte Douglas

Fri 9/5

7:37 pm-12:53 am

1 stop5h 16m

Buffalo

Tue 9/9

6:04 am-12:27 pm

1 stop6h 23m

$212

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Buffalo from

How to get the cheapest flight ticket from South Carolina to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of February, then book flights to Buffalo from South Carolina during September instead. Flights to Buffalo in September, while not as cheap as those in February, still average around $266.

What is the cheapest day to depart on your flight to Buffalo?

Our data shows that Tuesday is the least expensive day to fly to Buffalo. Tickets to fly out on this day can be as low as $266. Flights from South Carolina to Buffalo on a Sunday will generally be more expensive and average around $487. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Buffalo?

In the afternoon is the cheapest time of day to fly from South Carolina to Buffalo when you can find flight prices for as low as $290. Flying to Buffalo in the afternoon is an ideal time because this is during off-peak travel hours. At noon is when there is more demand to fly to Buffalo, so prices are often more expensive at around $332 per ticket.

How far in advance should I book a flight to Buffalo?

You are more likely to see cheaper flights to Buffalo from South Carolina when booking weeks ahead of your departure date. In general, you can expect to find flights to Buffalo for around $304 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Buffalo from South Carolina for as low as $227 on momondo.

Cheap South Carolina to Buffalo flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Buffalo

Best Price Found

$80

Fastest flight time

1h 44m

Direct flights

Every day

Airports in Buffalo

1 airport
The best one-way flight to Buffalo from South Carolina in the past 72 hours is $80. The best round-trip flight deal from South Carolina to Buffalo found on momondo in the last 72 hours is $159.
The fastest flight from South Carolina to Buffalo takes 1h 44m
Direct flights go from South Carolina to Buffalo every day.
There is 1 airport near Buffalo: Buffalo (BUF)
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Buffalo Airport?

    Prices for flights from South Carolina to Buffalo Airport refresh daily.

  • How many operators does momondo search for flights from South Carolina to Buffalo Airport?

  • How old do you have to be to fly from South Carolina to Buffalo Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The necessary travel and health documents for your Buffalo Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from South Carolina to Buffalo

Compare and see reviews for airlines that fly from South Carolina to Buffalo with momondo
Airline
Rating
Free Cancellation
Price
JetBluePriceFrom $160Free CancellationRating
7.2
2,915 reviews
Search JetBlue flights
United AirlinesPriceFrom $198Free CancellationRating
7.4
8,917 reviews
Search United Airlines flights
American AirlinesPriceFrom $200Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $207Free CancellationRating
8.0
7,985 reviews
Search Delta flights
SouthwestPriceFrom $233Free CancellationRating
8.0
4,244 reviews
Search Southwest flights

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Williamsville
Amherst
Tonawanda
Cheektowaga
Grand Island
Lockport
Orchard Park
West Seneca
East Aurora
Bowmansville
Eden
Angola

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Buffalo?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from South Carolina to Buffalo. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from South Carolina to Buffalo with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Buffalo from South Carolina with this policy.

How can momondo help me find flights from South Carolina to Buffalo?

Once you have performed a search for South Carolina to Buffalo flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from South Carolina to Buffalo right now. Can momondo alert me if prices change?

Price alerts on flights to Buffalo from South Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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