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Cheap flights from South Carolina to Buffalo from $81

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Buffalo departing on 12/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from South Carolina to Buffalo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
10:33 pm - 2:15 pmCLT-BUF
15h 42m1 stop
Frontier Logo
3:18 pm - 9:50 amBUF-CLT
18h 32m1 stop
$187Frontier
Find Deal
Fri, Dec 5 - Mon, Dec 8
JetBlue Logo
3:30 pm - 11:55 pmCHS-BUF
8h 25m1 stop
JetBlue Logo
12:25 pm - 7:05 pmBUF-CHS
6h 40m1 stop
$189JetBlue
Find Deal
Thu, May 14 - Sun, May 17
Frontier Logo
8:52 am - 2:15 pmCLT-BUF
5h 23m1 stop
Frontier Logo
3:18 pm - 7:57 amBUF-CLT
16h 39m1 stop
$197Frontier
Find Deal
Sat, Dec 6 - Sat, Dec 13
Delta Logo
10:25 am - 5:39 pmCHS-BUF
7h 14m1 stop
Delta Logo
6:00 am - 1:37 pmBUF-CHS
7h 37m1 stop
$199Delta
Find Deal
Thu, Jan 15 - Sun, Jan 18
American Airlines Logo
6:22 am - 10:59 amSAV-BUF
4h 37m1 stop
American Airlines Logo
7:33 pm - 11:59 pmBUF-SAV
4h 26m1 stop
$199American Airlines
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Fri, Feb 13 - Sun, Feb 15
American Airlines Logo
8:08 pm - 11:59 pmCHS-BUF
3h 51m1 stop
American Airlines Logo
7:15 pm - 12:05 amBUF-CHS
4h 50m1 stop
$201American Airlines
Find Deal
Mon, Dec 29 - Mon, Jan 5
American Airlines Logo
8:24 pm - 12:07 amSAV-BUF
3h 43m1 stop
American Airlines Logo
6:00 am - 12:31 pmBUF-SAV
6h 31m1 stop
$201American Airlines
Find Deal
Sat, Dec 13 - Sun, Dec 14
Delta Logo
5:38 pm - 12:16 amSAV-BUF
6h 38m1 stop
Delta Logo
3:38 pm - 8:54 pmBUF-SAV
5h 16m1 stop
$203Delta
Find Deal
Sat, Feb 14 - Wed, Feb 18
United Airlines Logo
10:12 am - 11:15 pmSAV-BUF
13h 03m2 stops
United Airlines Logo
6:00 am - 1:04 pmBUF-SAV
7h 04m1 stop
$232United Airlines
Find Deal
Sat, Dec 6 - Sun, Dec 7
United Airlines Logo
10:00 am - 2:22 pmCAE-BUF
4h 22m1 stop
United Airlines Logo
11:35 am - 10:07 pmBUF-CAE
10h 32m2 stops
$337United Airlines
Find Deal
Thu, Dec 11 - Mon, Dec 15

Frontier flights from South Carolina to Buffalo

Our best Frontier deals on South Carolina to Buffalo flight tickets
Frontier
Dec 5
CLT10:33 pmCharlotte Douglas
15h 42m
1 stop
BUF2:15 pmBuffalo
Dec 8
BUF3:18 pmBuffalo
18h 32m
1 stop
CLT9:50 amCharlotte Douglas
$187
Find similar
Frontier
Dec 6
CLT8:52 amCharlotte Douglas
5h 23m
1 stop
BUF2:15 pmBuffalo
Dec 13
BUF3:18 pmBuffalo
16h 39m
1 stop
CLT7:57 amCharlotte Douglas
$197
Find similar
Frontier
Dec 12
CLT10:33 pmCharlotte Douglas
15h 42m
1 stop
BUF2:15 pmBuffalo
Dec 14
BUF3:18 pmBuffalo
18h 19m
1 stop
CLT9:37 amCharlotte Douglas
$212
Find similar

Delta flights from South Carolina to Buffalo

Our best Delta deals on South Carolina to Buffalo flight tickets
Delta
Jan 15
CHS10:25 amCharleston
7h 14m
1 stop
BUF5:39 pmBuffalo
Jan 18
BUF6:00 amBuffalo
7h 37m
1 stop
CHS1:37 pmCharleston
$199
Find similar
Delta
Feb 14
SAV5:38 pmSavannah/Hilton Head
6h 38m
1 stop
BUF12:16 amBuffalo
Feb 18
BUF3:38 pmBuffalo
5h 16m
1 stop
SAV8:54 pmSavannah/Hilton Head
$203
Find similar
Delta
Dec 29
CHS4:56 pmCharleston
6h 32m
1 stop
BUF11:28 pmBuffalo
Jan 7
BUF6:03 amBuffalo
4h 56m
1 stop
CHS10:59 amCharleston
$230
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 23, 2025.
Use the filters below to find and compare flights from South Carolina to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteBuffalo

CLT - BUF

CLTBUF

Charlotte Douglas

Fri 12/5

10:33 pm-2:15 pm

1 stop15h 42m

Buffalo

Mon 12/8

3:18 pm-9:50 am

1 stop18h 32m

$187

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Thu 5/14

3:30 pm-11:55 pm

1 stop8h 25m

Buffalo

Sun 5/17

12:25 pm-7:05 pm

1 stop6h 40m

$189

CharlotteBuffalo

CLT - BUF

CLTBUF

Charlotte Douglas

Sat 12/6

8:52 am-2:15 pm

1 stop5h 23m

Buffalo

Sat 12/13

3:18 pm-7:57 am

1 stop16h 39m

$197

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Thu 1/15

10:25 am-5:39 pm

1 stop7h 14m

Buffalo

Sun 1/18

6:00 am-1:37 pm

1 stop7h 37m

$199

SavannahBuffalo

SAV - BUF

SAVBUF

Savannah/Hilton Head

Fri 2/13

6:22 am-10:59 am

1 stop4h 37m

Buffalo

Sun 2/15

7:33 pm-11:59 pm

1 stop4h 26m

$199

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Mon 12/29

8:08 pm-11:59 pm

1 stop3h 51m

Buffalo

Mon 1/5

7:15 pm-12:05 am

1 stop4h 50m

$201

SavannahBuffalo

SAV - BUF

SAVBUF

Savannah/Hilton Head

Sat 12/13

8:24 pm-12:07 am

1 stop3h 43m

Buffalo

Sun 12/14

6:00 am-12:31 pm

1 stop6h 31m

$201

SavannahBuffalo

SAV - BUF

SAVBUF

Savannah/Hilton Head

Sat 2/14

5:38 pm-12:16 am

1 stop6h 38m

Buffalo

Wed 2/18

3:38 pm-8:54 pm

1 stop5h 16m

$203

SavannahBuffalo

SAV - BUF

SAVBUF

Savannah/Hilton Head

Sat 12/6

10:12 am-11:15 pm

2 stops13h 03m

Buffalo

Sun 12/7

6:00 am-1:04 pm

1 stop7h 04m

$232

ColumbiaBuffalo

CAE - BUF

CAEBUF

Columbia Metropolitan

Thu 12/11

10:00 am-2:22 pm

1 stop4h 22m

Buffalo

Mon 12/15

11:35 am-10:07 pm

2 stops10h 32m

$337

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Buffalo from

How to get the cheapest flight ticket from South Carolina to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of February, then book flights to Buffalo from South Carolina during October instead. Flights to Buffalo in October, while not as cheap as those in February, still average around $231.

What is the cheapest day to depart on your flight to Buffalo?

Our data shows that Tuesday is the least expensive day to fly to Buffalo. Tickets to fly out on this day can be as low as $266. Flights from South Carolina to Buffalo on a Sunday will generally be more expensive and average around $487. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Buffalo?

In the afternoon is the cheapest time of day to fly from South Carolina to Buffalo when you can find flight prices for as low as $290. Flying to Buffalo in the afternoon is an ideal time because this is during off-peak travel hours. At noon is when there is more demand to fly to Buffalo, so prices are often more expensive at around $332 per ticket.

How far in advance should I book a flight to Buffalo?

You are more likely to see cheaper flights to Buffalo from South Carolina when booking weeks ahead of your departure date. In general, you can expect to find flights to Buffalo for around $296 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Buffalo from South Carolina for as low as $220 on momondo.

Can stopping save me money on South Carolina to Buffalo flights?

You could potentially save up to 37% on your flight if you consider stops on a South Carolina to Buffalo flight.

Cheap South Carolina to Buffalo flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Buffalo

Fastest flight time

1h 34m

Direct flights

Mon, Wed, Thu, Fri, Sat and Sun

Airports in Buffalo

1 airport
The fastest flight from South Carolina to Buffalo takes 1h 34m
Direct flights go from South Carolina to Buffalo on Monday, Wednesday, Thursday, Friday, Saturday and Sunday. There are no airlines offering direct flights.
There is 1 airport near Buffalo: Buffalo (BUF)
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Buffalo Airport?

    Prices for flights from South Carolina to Buffalo Airport refresh daily.

  • How many operators does momondo search for flights from South Carolina to Buffalo Airport?

  • How old do you have to be to fly from South Carolina to Buffalo Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The necessary travel and health documents for your Buffalo Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from South Carolina to Buffalo

Compare and see reviews for airlines that fly from South Carolina to Buffalo with momondo
Airline
Rating
Free Cancellation
Price
JetBluePriceFrom $135Free CancellationRating
7.2
2,902 reviews
Search JetBlue flights
American AirlinesPriceFrom $195Free CancellationRating
7.2
11,046 reviews
Search American Airlines flights
United AirlinesPriceFrom $202Free CancellationRating
7.4
9,036 reviews
Search United Airlines flights
DeltaPriceFrom $216Free CancellationRating
7.9
7,997 reviews
Search Delta flights
SouthwestPriceFrom $236Free CancellationRating
8.0
4,252 reviews
Search Southwest flights

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Amherst
Tonawanda
Grand Island
Williamsville
Lockport
Orchard Park
West Seneca
East Aurora
Bowmansville
Eden
Angola

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Buffalo?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from South Carolina to Buffalo. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from South Carolina to Buffalo with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Buffalo from South Carolina with this policy.

How can momondo help me find flights from South Carolina to Buffalo?

Once you have performed a search for South Carolina to Buffalo flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from South Carolina to Buffalo right now. Can momondo alert me if prices change?

Price alerts on flights to Buffalo from South Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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