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Cheap flights from South Carolina to Buffalo from $72

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Buffalo departing on 10/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from South Carolina to Buffalo

Cheap round-trip flights

Frontier Logo
2:14 pm - 8:18 pmCLT-BUF
6h 04m1 stop
Frontier Logo
9:13 pm - 8:00 amBUF-CLT
10h 47m1 stop
$144Frontier
Find Deal
Fri, Oct 17 - Sun, Oct 19
Frontier Logo
2:14 pm - 8:18 pmCLT-BUF
6h 04m1 stop
Frontier Logo
9:13 pm - 12:44 pmBUF-CLT
15h 31m1 stop
$152Frontier
Find Deal
Mon, Oct 20 - Fri, Oct 24
JetBlue Logo
5:05 am - 10:19 amCHS-BUF
5h 14m1 stop
JetBlue Logo
7:00 am - 1:19 pmBUF-CHS
6h 19m1 stop
$181JetBlue
Find Deal
Sun, Nov 2 - Tue, Nov 4
JetBlue Logo
7:00 am - 2:04 pmCHS-BUF
7h 04m1 stop
JetBlue Logo
7:00 am - 1:19 pmBUF-CHS
6h 19m1 stop
$185JetBlue
Find Deal
Sat, Oct 25 - Tue, Oct 28
Delta Logo
7:05 pm - 11:39 pmCHS-BUF
4h 34m1 stop
Delta Logo
6:20 am - 10:42 amBUF-CHS
4h 22m1 stop
$217Delta
Find Deal
Thu, Oct 23 - Thu, Oct 30
Delta Logo
6:00 am - 10:31 amCLT-BUF
4h 31m1 stop
Delta Logo
11:15 am - 6:14 pmBUF-CLT
6h 59m1 stop
$217Delta
Find Deal
Thu, Oct 16 - Wed, Jan 14
United Airlines Logo
2:52 pm - 10:58 pmCHS-BUF
8h 06m2 stops
United Airlines Logo
5:00 am - 2:09 pmBUF-CHS
9h 09m2 stops
$218United Airlines
Find Deal
Fri, Oct 31 - Sun, Nov 2
Multiple Airlines Logo
2:14 pm - 8:18 pmCLT-BUF
6h 04m1 stop
Multiple Airlines Logo
9:13 pm - 7:47 amBUF-CLT
10h 34m1 stop
$222Multiple Airlines
Find Deal
Fri, Oct 17 - Mon, Oct 20
Multiple Airlines Logo
10:06 pm - 8:18 pmCLT-BUF
22h 12m1 stop
Multiple Airlines Logo
9:13 pm - 7:47 amBUF-CLT
10h 34m1 stop
$225Multiple Airlines
Find Deal
Thu, Oct 16 - Mon, Oct 20
United Airlines Logo
4:30 pm - 10:58 pmSAV-BUF
6h 28m1 stop
United Airlines Logo
12:15 pm - 7:27 pmBUF-SAV
7h 12m2 stops
$228United Airlines
Find Deal
Thu, Oct 30 - Sat, Nov 1

Delta flights from South Carolina to Buffalo

Our best Delta deals on South Carolina to Buffalo flight tickets
Delta
Oct 23
CHS7:05 pmCharleston
4h 34m
1 stop
BUF11:39 pmBuffalo
Oct 30
BUF6:20 amBuffalo
4h 22m
1 stop
CHS10:42 amCharleston
$217
Find similar
Delta
Mar 3
SAV5:35 pmSavannah/Hilton Head
6h 14m
1 stop
BUF11:49 pmBuffalo
Mar 4
BUF11:15 amBuffalo
5h 41m
1 stop
SAV4:56 pmSavannah/Hilton Head
$223
Find similar
Delta
Nov 7
CLT7:00 amCharlotte Douglas
6h 47m
1 stop
BUF1:47 pmBuffalo
Nov 10
BUF6:00 amBuffalo
5h 16m
1 stop
CLT11:16 amCharlotte Douglas
$237
Find similar

Frontier flights from South Carolina to Buffalo

Our best Frontier deals on South Carolina to Buffalo flight tickets
Frontier
Oct 17
CLT2:14 pmCharlotte Douglas
6h 04m
1 stop
BUF8:18 pmBuffalo
Oct 19
BUF9:13 pmBuffalo
10h 47m
1 stop
CLT8:00 amCharlotte Douglas
$144
Find similar
Frontier
Oct 20
CLT2:14 pmCharlotte Douglas
6h 04m
1 stop
BUF8:18 pmBuffalo
Oct 24
BUF9:13 pmBuffalo
15h 31m
1 stop
CLT12:44 pmCharlotte Douglas
$152
Find similar
Frontier
Oct 3
CLT8:51 pmCharlotte Douglas
21h 23m
1 stop
BUF6:14 pmBuffalo
Oct 5
BUF4:57 pmBuffalo
23h 28m
1 stop
CLT4:25 pmCharlotte Douglas
$169
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 25, 2025.
Use the filters below to find and compare flights from South Carolina to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteBuffalo

CLT - BUF

CLTBUF

Charlotte Douglas

Fri 10/17

2:14 pm-8:18 pm

1 stop6h 04m

Buffalo

Sun 10/19

9:13 pm-8:00 am

1 stop10h 47m

$144

CharlotteBuffalo

CLT - BUF

CLTBUF

Charlotte Douglas

Mon 10/20

2:14 pm-8:18 pm

1 stop6h 04m

Buffalo

Fri 10/24

9:13 pm-12:44 pm

1 stop15h 31m

$152

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Sun 11/2

5:05 am-10:19 am

1 stop5h 14m

Buffalo

Tue 11/4

7:00 am-1:19 pm

1 stop6h 19m

$181

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Sat 10/25

7:00 am-2:04 pm

1 stop7h 04m

Buffalo

Tue 10/28

7:00 am-1:19 pm

1 stop6h 19m

$185

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Thu 10/23

7:05 pm-11:39 pm

1 stop4h 34m

Buffalo

Thu 10/30

6:20 am-10:42 am

1 stop4h 22m

$217

CharlotteBuffalo

CLT - BUF

CLTBUF

Charlotte Douglas

Thu 10/16

6:00 am-10:31 am

1 stop4h 31m

Buffalo

Wed 1/14

11:15 am-6:14 pm

1 stop6h 59m

$217

CharlestonBuffalo

CHS - BUF

CHSBUF

Charleston

Fri 10/31

2:52 pm-10:58 pm

2 stops8h 06m

Buffalo

Sun 11/2

5:00 am-2:09 pm

2 stops9h 09m

$218

CharlotteBuffalo

CLT - BUF

CLTBUF

Charlotte Douglas

Fri 10/17

2:14 pm-8:18 pm

1 stop6h 04m

Buffalo

Mon 10/20

9:13 pm-7:47 am

1 stop10h 34m

$222

CharlotteBuffalo

CLT - BUF

CLTBUF

Charlotte Douglas

Thu 10/16

10:06 pm-8:18 pm

1 stop22h 12m

Buffalo

Mon 10/20

9:13 pm-7:47 am

1 stop10h 34m

$225

SavannahBuffalo

SAV - BUF

SAVBUF

Savannah/Hilton Head

Thu 10/30

4:30 pm-10:58 pm

1 stop6h 28m

Buffalo

Sat 11/1

12:15 pm-7:27 pm

2 stops7h 12m

$228

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Buffalo from

How to get the cheapest flight ticket from South Carolina to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of February, then book flights to Buffalo from South Carolina during October instead. Flights to Buffalo in October, while not as cheap as those in February, still average around $256.

What is the cheapest day to depart on your flight to Buffalo?

Our data shows that Tuesday is the least expensive day to fly to Buffalo. Tickets to fly out on this day can be as low as $266. Flights from South Carolina to Buffalo on a Sunday will generally be more expensive and average around $487. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Buffalo?

In the afternoon is the cheapest time of day to fly from South Carolina to Buffalo when you can find flight prices for as low as $290. Flying to Buffalo in the afternoon is an ideal time because this is during off-peak travel hours. At noon is when there is more demand to fly to Buffalo, so prices are often more expensive at around $332 per ticket.

How far in advance should I book a flight to Buffalo?

You are more likely to see cheaper flights to Buffalo from South Carolina when booking weeks ahead of your departure date. In general, you can expect to find flights to Buffalo for around $298 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Buffalo from South Carolina for as low as $222 on momondo.

Cheap South Carolina to Buffalo flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Buffalo

Fastest flight time

1h 34m

Direct flights

Every day

Airports in Buffalo

1 airport
The fastest flight from South Carolina to Buffalo takes 1h 34m
Direct flights go from South Carolina to Buffalo every day.
There is 1 airport near Buffalo: Buffalo (BUF)
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Buffalo Airport?

    Prices for flights from South Carolina to Buffalo Airport refresh daily.

  • How many operators does momondo search for flights from South Carolina to Buffalo Airport?

  • How old do you have to be to fly from South Carolina to Buffalo Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The necessary travel and health documents for your Buffalo Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from South Carolina to Buffalo

Compare and see reviews for airlines that fly from South Carolina to Buffalo with momondo
Airline
Rating
Free Cancellation
Price
JetBluePriceFrom $135Free CancellationRating
7.2
2,911 reviews
Search JetBlue flights
American AirlinesPriceFrom $195Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $198Free CancellationRating
7.4
8,928 reviews
Search United Airlines flights
DeltaPriceFrom $212Free CancellationRating
7.9
7,973 reviews
Search Delta flights
SouthwestPriceFrom $236Free CancellationRating
8.0
4,246 reviews
Search Southwest flights

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Tonawanda
Amherst
Williamsville
Grand Island
Orchard Park
Lockport
West Seneca
East Aurora
Bowmansville
Eden
Angola

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Buffalo?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from South Carolina to Buffalo. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from South Carolina to Buffalo with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Buffalo from South Carolina with this policy.

How can momondo help me find flights from South Carolina to Buffalo?

Once you have performed a search for South Carolina to Buffalo flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from South Carolina to Buffalo right now. Can momondo alert me if prices change?

Price alerts on flights to Buffalo from South Carolina are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Buffalo trip

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