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Cheap flights from Santa Ana, California to Missouri from $64

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana, California to Missouri departing on 2/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Santa Ana, California to Missouri

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
10:30 am - 8:08 pm
SNA
-
STL
7h 38m1 stop
Frontier Logo
3:46 pm - 10:58 am
STL
-
SNA
21h 12m1 stop
$164Frontier
Mon, Jan 19 - Wed, Jan 28
Frontier Logo
2:39 pm - 8:48 pm
SNA
-
STL
28h 09m1 stop
Frontier Logo
3:46 pm - 10:58 am
STL
-
SNA
21h 12m1 stop
$166Frontier
Thu, Jan 22 - Wed, Jan 28
Spirit Airlines Logo
4:37 pm - 11:33 pm
SNA
-
MCI
4h 56m1 stop
Spirit Airlines Logo
7:00 am - 12:25 pm
MCI
-
SNA
7h 25m1 stop
$178Spirit Airlines
Thu, Jan 29 - Tue, Feb 3
Spirit Airlines Logo
1:20 pm - 11:33 pm
SNA
-
MCI
8h 13m1 stop
Spirit Airlines Logo
7:00 am - 3:42 pm
MCI
-
SNA
10h 42m1 stop
$186Spirit Airlines
Sat, Jan 24 - Sat, Jan 31
Multiple Airlines Logo
10:30 am - 8:08 pm
SNA
-
STL
7h 38m1 stop
Multiple Airlines Logo
3:46 pm - 8:57 pm
STL
-
SNA
31h 11m2 stops
$189Multiple Airlines
Mon, Jan 19 - Wed, Jan 28
Multiple Airlines Logo
1:20 pm - 11:33 pm
SNA
-
MCI
8h 13m1 stop
Multiple Airlines Logo
8:41 pm - 2:11 pm
MCI
-
SNA
19h 30m2 stops
$201Multiple Airlines
Wed, Feb 4 - Sun, Feb 8
United Airlines Logo
10:51 am - 9:58 pm
SNA
-
SGF
9h 07m1 stop
United Airlines Logo
9:00 am - 3:10 pm
SGF
-
SNA
8h 10m1 stop
$369United Airlines
Wed, Jan 28 - Sat, Jan 31
American Airlines Logo
7:50 am - 6:04 pm
SNA
-
SGF
8h 14m1 stop
American Airlines Logo
5:00 pm - 10:01 pm
SGF
-
SNA
7h 01m1 stop
$374American Airlines
Wed, Jan 7 - Mon, Jan 12
American Airlines Logo
12:38 pm - 9:19 pm
SNA
-
SGF
6h 41m2 stops
American Airlines Logo
5:00 pm - 10:01 pm
SGF
-
SNA
7h 01m1 stop
$379American Airlines
Wed, Jan 7 - Mon, Jan 12
United Airlines Logo
11:10 am - 8:24 pm
SNA
-
COU
7h 14m1 stop
United Airlines Logo
3:10 pm - 10:30 pm
COU
-
SNA
9h 20m1 stop
$383United Airlines
Sat, Feb 14 - Wed, Feb 18

Delta flights from Santa Ana, California to Missouri

Our best Delta deals on Santa Ana, California to Missouri flight tickets
Delta
Jan 22
SNA11:15 amSanta Ana J. Wayne/Orange Cnty
10h 10m
2 stops
STL11:25 pmLambert-St Louis
Jan 27
STL6:10 amLambert-St Louis
12h 24m
2 stops
SNA4:34 pmSanta Ana J. Wayne/Orange Cnty
$276
Find similar
Delta
Jan 22
SNA11:15 amSanta Ana J. Wayne/Orange Cnty
10h 10m
2 stops
STL11:25 pmLambert-St Louis
Jan 27
STL6:00 amLambert-St Louis
7h 49m
1 stop
SNA11:49 amSanta Ana J. Wayne/Orange Cnty
$324
Find similar
Delta
Jun 10
SNA5:05 pmSanta Ana J. Wayne/Orange Cnty
5h 15m
1 stop
MCI12:20 amKansas City
Jun 16
MCI6:40 amKansas City
7h 39m
1 stop
SNA12:19 pmSanta Ana J. Wayne/Orange Cnty
$367
Find similar

Alaska Airlines flights from Santa Ana, California to Missouri

Our best Alaska Airlines deals on Santa Ana, California to Missouri flight tickets
Alaska Airlines
Jan 22
SNA5:00 pmSanta Ana J. Wayne/Orange Cnty
18h 54m
1 stop
STL1:54 pmLambert-St Louis
Jan 27
STL2:50 pmLambert-St Louis
21h 15m
1 stop
SNA10:05 amSanta Ana J. Wayne/Orange Cnty
$332
Find similar
Alaska Airlines
Feb 26
SNA8:49 pmSanta Ana J. Wayne/Orange Cnty
22h 40m
1 stop
MCI9:29 pmKansas City
Mar 1
MCI2:49 pmKansas City
30h 17m
1 stop
SNA7:06 pmSanta Ana J. Wayne/Orange Cnty
$356
Find similar
Alaska Airlines
Jan 22
SNA12:33 pmSanta Ana J. Wayne/Orange Cnty
23h 21m
1 stop
STL1:54 pmLambert-St Louis
Jan 26
STL2:50 pmLambert-St Louis
9h 37m
1 stop
SNA10:27 pmSanta Ana J. Wayne/Orange Cnty
$358
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana, California to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 27, 2025.
Use the filters below to find and compare flights from Santa Ana, California to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Mon 1/19

10:30 am-8:08 pm

1 stop7h 38m

Lambert-St Louis

Wed 1/28

3:46 pm-10:58 am

1 stop21h 12m

$164

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Thu 1/22

2:39 pm-8:48 pm

1 stop28h 09m

Lambert-St Louis

Wed 1/28

3:46 pm-10:58 am

1 stop21h 12m

$166

Santa AnaKansas City

SNA - MCI

SNAMCI

Santa Ana J. Wayne/Orange Cnty

Thu 1/29

4:37 pm-11:33 pm

1 stop4h 56m

Kansas City

Tue 2/3

7:00 am-12:25 pm

1 stop7h 25m

$178

Santa AnaKansas City

SNA - MCI

SNAMCI

Santa Ana J. Wayne/Orange Cnty

Sat 1/24

1:20 pm-11:33 pm

1 stop8h 13m

Kansas City

Sat 1/31

7:00 am-3:42 pm

1 stop10h 42m

$186

Santa AnaSt. Louis

SNA - STL

SNASTL

Santa Ana J. Wayne/Orange Cnty

Mon 1/19

10:30 am-8:08 pm

1 stop7h 38m

Lambert-St Louis

Wed 1/28

3:46 pm-8:57 pm

2 stops31h 11m

$189

Santa AnaKansas City

SNA - MCI

SNAMCI

Santa Ana J. Wayne/Orange Cnty

Wed 2/4

1:20 pm-11:33 pm

1 stop8h 13m

Kansas City

Sun 2/8

8:41 pm-2:11 pm

2 stops19h 30m

$201

Santa AnaSpringfield

SNA - SGF

SNASGF

Santa Ana J. Wayne/Orange Cnty

Wed 1/28

10:51 am-9:58 pm

1 stop9h 07m

Springfield-Branson

Sat 1/31

9:00 am-3:10 pm

1 stop8h 10m

$369

Santa AnaSpringfield

SNA - SGF

SNASGF

Santa Ana J. Wayne/Orange Cnty

Wed 1/7

7:50 am-6:04 pm

1 stop8h 14m

Springfield-Branson

Mon 1/12

5:00 pm-10:01 pm

1 stop7h 01m

$374

Santa AnaSpringfield

SNA - SGF

SNASGF

Santa Ana J. Wayne/Orange Cnty

Wed 1/7

12:38 pm-9:19 pm

2 stops6h 41m

Springfield-Branson

Mon 1/12

5:00 pm-10:01 pm

1 stop7h 01m

$379

Santa AnaColumbia

SNA - COU

SNACOU

Santa Ana J. Wayne/Orange Cnty

Sat 2/14

11:10 am-8:24 pm

1 stop7h 14m

Columbia Regional

Wed 2/18

3:10 pm-10:30 pm

1 stop9h 20m

$383

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Missouri from

How to get the cheapest flight ticket from Santa Ana, California to Missouri

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Missouri?

In general, October is the cheapest month to fly from Santa Ana, California to Missouri. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $329. If you aren’t able to travel to Missouri during the month of October, then flying in August is also cheap. Prices for this month can be found on momondo for an average of $374.

What is the cheapest day to depart on your flight to Missouri?

The cheapest day to depart from Santa Ana, California to Missouri is on a Tuesday when prices can be found for as low as $396. Flights from Santa Ana, California to Missouri on a Saturday will generally be more expensive and average around $519. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Missouri?

According to our data, the cheapest time of day to fly to Missouri is in the evening. momondo users have found flights departing from Santa Ana, California to Missouri in the evening for as low as $352. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Missouri are more costly at noon, with an average ticket price of $456. Departure times at noon fall within the peak daily travel times, which is why tickets can be more expensive.

Cheap Santa Ana, California to Missouri flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana, California to Missouri

Fastest flight time

4h 56m

Direct flights

None
The fastest flight from Santa Ana, California to Missouri takes 4h 56m
There are no direct flights from Santa Ana, California to Missouri. There are no popular flight routes from Santa Ana, California to Missouri.
Search flight deals

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Missouri?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Missouri refresh daily.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Missouri?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Missouri?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Santa Ana J. Wayne/Orange Cnty Airport to Missouri.

  • What documentation or ID do you need to fly to Missouri?

    The travel and health documents required for your trip to Missouri can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Missouri. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Santa Ana, California to Missouri

Compare and see reviews for airlines that fly from Santa Ana, California to Missouri with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $128Free CancellationRating
7.9
8,019 reviews
Search Delta flights
Spirit AirlinesPriceFrom $141Free CancellationRating
6.3
8,210 reviews
Search Spirit Airlines flights
FrontierPriceFrom $150Free CancellationRating
5.8
3,071 reviews
Search Frontier flights
SouthwestPriceFrom $206Free CancellationRating
8.0
4,257 reviews
Search Southwest flights
American AirlinesPriceFrom $268Free CancellationRating
7.2
11,066 reviews
Search American Airlines flights
United AirlinesPriceFrom $293Free CancellationRating
7.4
9,114 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to Missouri?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Santa Ana to Missouri for you.

Can I find flights from Santa Ana to Missouri with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Santa Ana to Missouri flights to just show those with flexible booking policies.

How can momondo help me find flights from Santa Ana to Missouri?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Santa Ana to Missouri.

I’m not ready to book a flight from Santa Ana to Missouri right now. Can momondo alert me if prices change?

Price alerts on flights to Missouri from Santa Ana are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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