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Cheap flights from Santa Ana, California to Greenville from $195

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana, California to Greenville departing on 10/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Santa Ana, California to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:15 am - 6:45 pmSNA  Santa Ana J. Wayne/Orange Cnty-GSP Greenville
8h 30m1 stop Charlotte Douglas
American Airlines Logo
7:46 am - 2:03 pmGSP  Greenville-SNA Santa Ana J. Wayne/Orange Cnty
9h 17m1 stop Dallas/Fort Worth
$305American Airlines
Tue, Oct 27 - Tue, Nov 3
Delta Logo
11:38 am - 8:37 pmSNA  Santa Ana J. Wayne/Orange Cnty-GSP Greenville
5h 59m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:00 pm - 6:29 pmGSP  Greenville-SNA Santa Ana J. Wayne/Orange Cnty
7h 29m1 stop Atlanta Hartsfield-Jackson
$305Delta
Wed, Sep 23 - Sat, Oct 3
Delta Logo
2:00 pm - 10:55 pmSNA  Santa Ana J. Wayne/Orange Cnty-GSP Greenville
5h 55m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:00 pm - 6:29 pmGSP  Greenville-SNA Santa Ana J. Wayne/Orange Cnty
7h 29m1 stop Atlanta Hartsfield-Jackson
$305Delta
Tue, Sep 22 - Sat, Oct 3
Delta Logo
2:00 pm - 10:55 pmSNA  Santa Ana J. Wayne/Orange Cnty-GSP Greenville
5h 55m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:00 pm - 6:29 pmGSP  Greenville-SNA Santa Ana J. Wayne/Orange Cnty
7h 29m1 stop Atlanta Hartsfield-Jackson
$305Delta
Sat, Sep 26 - Sat, Oct 3
American Airlines Logo
10:35 am - 10:17 pmSNA  Santa Ana J. Wayne/Orange Cnty-GSP Greenville
8h 42m1 stop Dallas/Fort Worth
American Airlines Logo
7:00 am - 10:50 amGSP  Greenville-SNA Santa Ana J. Wayne/Orange Cnty
6h 50m1 stop Dallas/Fort Worth
$370American Airlines
Fri, Sep 4 - Sat, Sep 5
American Airlines Logo
10:35 am - 10:11 pmSNA  Santa Ana J. Wayne/Orange Cnty-GSP Greenville
8h 36m1 stop Dallas/Fort Worth
American Airlines Logo
5:24 pm - 10:19 pmGSP  Greenville-SNA Santa Ana J. Wayne/Orange Cnty
7h 55m1 stop Dallas/Fort Worth
$392American Airlines
Tue, Sep 29 - Thu, Oct 1
United Airlines Logo
10:47 am - 11:18 pmSNA  Santa Ana J. Wayne/Orange Cnty-GSP Greenville
9h 31m1 stop Chicago O'Hare Intl
United Airlines Logo
4:29 pm - 10:00 pmGSP  Greenville-SNA Santa Ana J. Wayne/Orange Cnty
8h 31m1 stop Denver Intl
$394United Airlines
Fri, Nov 6 - Thu, Nov 12
Southwest Logo
7:30 am - 8:55 pmSNA  Santa Ana J. Wayne/Orange Cnty-GSP Greenville
10h 25m2 stops Austin Bergstrom Nashville Intl
Southwest Logo
8:25 am - 4:25 pmGSP  Greenville-SNA Santa Ana J. Wayne/Orange Cnty
11h 00m2 stops Baltimore/Washington San Jose
$401Southwest
Tue, Sep 29 - Thu, Oct 1
Southwest Logo
8:25 am - 9:00 pmSNA  Santa Ana J. Wayne/Orange Cnty-GSP Greenville
9h 35m2 stops Las Vegas Harry Reid Intl Nashville Intl
Southwest Logo
7:05 am - 2:00 pmGSP  Greenville-SNA Santa Ana J. Wayne/Orange Cnty
9h 55m2 stops Nashville Intl Denver Intl
$401Southwest
Tue, Oct 27 - Tue, Nov 3
United Airlines Logo
9:10 pm - 11:17 amSNA  Santa Ana J. Wayne/Orange Cnty-GSP Greenville
11h 07m1 stop Newark
United Airlines Logo
4:29 pm - 9:09 pmGSP  Greenville-SNA Santa Ana J. Wayne/Orange Cnty
7h 40m1 stop Denver Intl
$415United Airlines
Tue, Oct 27 - Wed, Nov 4

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United Airlines flights from Santa Ana, California to Greenville

Our best United Airlines deals on Santa Ana, California to Greenville flight tickets
United Airlines
Nov 6
SNA10:47 amSanta Ana J. Wayne/Orange Cnty
9h 31m
1 stop
GSP11:18 pmGreenville
Nov 12
GSP4:29 pmGreenville
8h 31m
1 stop
SNA10:00 pmSanta Ana J. Wayne/Orange Cnty
$394
United Airlines
Oct 27
SNA9:10 pmSanta Ana J. Wayne/Orange Cnty
11h 07m
1 stop
GSP11:17 amGreenville
Nov 4
GSP4:29 pmGreenville
8h 31m
1 stop
SNA10:00 pmSanta Ana J. Wayne/Orange Cnty
$415
United Airlines
Nov 6
SNA8:46 amSanta Ana J. Wayne/Orange Cnty
11h 32m
2 stops
GSP11:18 pmGreenville
Nov 12
GSP4:29 pmGreenville
7h 40m
1 stop
SNA9:09 pmSanta Ana J. Wayne/Orange Cnty
$418

Southwest flights from Santa Ana, California to Greenville

Our best Southwest deals on Santa Ana, California to Greenville flight tickets
Southwest
Sep 29
SNA7:30 amSanta Ana J. Wayne/Orange Cnty
10h 25m
2 stops
GSP8:55 pmGreenville
Oct 1
GSP8:25 amGreenville
11h 00m
2 stops
SNA4:25 pmSanta Ana J. Wayne/Orange Cnty
$401
Southwest
Nov 6
SNA8:15 amSanta Ana J. Wayne/Orange Cnty
8h 55m
2 stops
GSP8:10 pmGreenville
Nov 12
GSP6:40 amGreenville
9h 55m
2 stops
SNA1:35 pmSanta Ana J. Wayne/Orange Cnty
$423
Southwest
Sep 8
SNA7:30 amSanta Ana J. Wayne/Orange Cnty
10h 30m
2 stops
GSP9:00 pmGreenville
Sep 15
GSP7:00 amGreenville
9h 35m
2 stops
SNA1:35 pmSanta Ana J. Wayne/Orange Cnty
$445

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana, California to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 15, 2026.
Use the filters below to find and compare flights from Santa Ana, California to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santa AnaGreenville

SNA Santa Ana J. Wayne/Orange Cnty - GSP Greenville

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 10/27

7:15 am-6:45 pm

1 stop8h 30m

Greenville

Tue 11/3

7:46 am-2:03 pm

1 stop9h 17m

$305

Santa AnaGreenville

SNA Santa Ana J. Wayne/Orange Cnty - GSP Greenville

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Wed 9/23

11:38 am-8:37 pm

1 stop5h 59m

Greenville

Sat 10/3

2:00 pm-6:29 pm

1 stop7h 29m

$305
Quickest round-trip

Santa AnaGreenville

SNA Santa Ana J. Wayne/Orange Cnty - GSP Greenville

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 9/22

2:00 pm-10:55 pm

1 stop5h 55m

Greenville

Sat 10/3

2:00 pm-6:29 pm

1 stop7h 29m

$305

Santa AnaGreenville

SNA Santa Ana J. Wayne/Orange Cnty - GSP Greenville

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Sat 9/26

2:00 pm-10:55 pm

1 stop5h 55m

Greenville

Sat 10/3

2:00 pm-6:29 pm

1 stop7h 29m

$305

Santa AnaGreenville

SNA Santa Ana J. Wayne/Orange Cnty - GSP Greenville

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Fri 9/4

10:35 am-10:17 pm

1 stop8h 42m

Greenville

Sat 9/5

7:00 am-10:50 am

1 stop6h 50m

$370

Santa AnaGreenville

SNA Santa Ana J. Wayne/Orange Cnty - GSP Greenville

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 9/29

10:35 am-10:11 pm

1 stop8h 36m

Greenville

Thu 10/1

5:24 pm-10:19 pm

1 stop7h 55m

$392

Santa AnaGreenville

SNA Santa Ana J. Wayne/Orange Cnty - GSP Greenville

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Fri 11/6

10:47 am-11:18 pm

1 stop9h 31m

Greenville

Thu 11/12

4:29 pm-10:00 pm

1 stop8h 31m

$394

Santa AnaGreenville

SNA Santa Ana J. Wayne/Orange Cnty - GSP Greenville

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 9/29

7:30 am-8:55 pm

2 stops10h 25m

Greenville

Thu 10/1

8:25 am-4:25 pm

2 stops11h 00m

$401

Santa AnaGreenville

SNA Santa Ana J. Wayne/Orange Cnty - GSP Greenville

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 10/27

8:25 am-9:00 pm

2 stops9h 35m

Greenville

Tue 11/3

7:05 am-2:00 pm

2 stops9h 55m

$401

Santa AnaGreenville

SNA Santa Ana J. Wayne/Orange Cnty - GSP Greenville

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 10/27

9:10 pm-11:17 am

1 stop11h 07m

Greenville

Wed 11/4

4:29 pm-9:09 pm

1 stop7h 40m

$415

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Santa Ana, California to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Greenville?

The month of May is another great option to travel to Greenville, with average flight prices from Santa Ana, California averaging around $433.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Thursday is the cheapest day to fly to Greenville from Santa Ana, California. The lowest ticket price found for a Thursday departure recently was $198. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $349. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the morning. Flights from Santa Ana, California to Greenville during this time can be as low as $336. Flights to Greenville are more costly at noon, with an average ticket price of $358. Departure times at noon fall within the peak daily travel times, which is why tickets can be more expensive.

Can stopping save me money on Santa Ana, California to Greenville flights?

You could potentially save up to 17% on your flight if you consider stops on a Santa Ana, California to Greenville flight.

How have Santa Ana, California to Greenville flight prices changed over time?

When to book flights from Santa Ana, California to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana, California to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana, California to Greenville (SNA to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana, California to Greenville

Fastest flight time

6h 36m

Direct flights

None
The fastest flight from Santa Ana, California to Greenville takes 6h 36m
There are no direct flights from Santa Ana, California to Greenville. There are no popular flight routes from Santa Ana, California to Greenville.
Search flight deals

Frequently asked questions about flying from Santa Ana, California to Greenville

  • How far is Santa Ana J. Wayne/Orange Cnty to Greenville by plane?

    Greenville is 2014.2 mi away from Santa Ana J. Wayne/Orange Cnty. Flights usually cover this in 6h 36m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport were last updated today.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents you'll need for your trip to Greenville Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Greenville Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santa Ana, California to Greenville?

Best airlines flying from Santa Ana, California to Greenville

Compare and see reviews for airlines that fly from Santa Ana, California to Greenville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $333Free CancellationRating
7.8
8,508 reviews
Search Delta flights
United AirlinesPriceFrom $336Free CancellationRating
7.4
10,111 reviews
Search United Airlines flights
American AirlinesPriceFrom $390Free CancellationRating
7.1
11,941 reviews
Search American Airlines flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Greer
Seneca
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to Greenville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Santa Ana to Greenville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Santa Ana to Greenville with flexible booking policies on momondo?

Flights from Santa Ana to Greenville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Santa Ana to Greenville?

momondo helps you find the best flight between Santa Ana and Greenville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santa Ana to Greenville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Santa Ana to Greenville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Greenville and let you know when they change.

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