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Cheap flights from Santa Ana, California to Greenville from $173

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana, California to Greenville departing on 4/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Santa Ana, California to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
9:20 pm - 9:09 am
SNA
-
GSP
8h 49m
1 stop
Delta Logo
5:42 am - 12:01 pm
GSP
-
SNA
9h 19m
1 stop
$331Delta
Thu, Apr 23 - Tue, Apr 28
Delta Logo
9:20 pm - 9:09 am
SNA
-
GSP
8h 49m
1 stop
Delta Logo
6:51 am - 5:53 pm
GSP
-
SNA
14h 02m
2 stops
$336Delta
Thu, Apr 23 - Tue, May 5
American Airlines Logo
1:23 pm - 10:40 pm
SNA
-
GSP
6h 17m
1 stop
American Airlines Logo
4:28 pm - 9:14 pm
GSP
-
SNA
7h 46m
1 stop
$346American Airlines
Wed, Apr 22 - Sat, Apr 25
American Airlines Logo
1:23 pm - 10:40 pm
SNA
-
GSP
6h 17m
1 stop
American Airlines Logo
5:20 am - 12:05 pm
GSP
-
SNA
9h 45m
2 stops
$357American Airlines
Wed, Apr 22 - Sat, Apr 25
Delta Logo
11:53 am - 9:38 pm
SNA
-
GSP
6h 45m
1 stop
Delta Logo
5:05 pm - 10:29 pm
GSP
-
SNA
8h 24m
1 stop
$359Delta
Wed, May 20 - Sat, May 23
American Airlines Logo
6:45 am - 4:21 pm
SNA
-
GSP
6h 36m
1 stop
American Airlines Logo
4:28 pm - 9:14 pm
GSP
-
SNA
7h 46m
1 stop
$363American Airlines
Sat, Apr 25 - Sat, May 2
United Airlines Logo
12:15 pm - 9:59 pm
SNA
-
GSP
6h 44m
1 stop
United Airlines Logo
6:36 am - 3:42 pm
GSP
-
SNA
12h 06m
2 stops
$368United Airlines
Sat, Apr 25 - Sat, May 2
Delta Logo
7:00 pm - 9:09 am
SNA
-
GSP
11h 09m
2 stops
Delta Logo
5:42 am - 5:53 pm
GSP
-
SNA
15h 11m
2 stops
$369Delta
Thu, Apr 23 - Tue, Apr 28
Delta Logo
9:20 pm - 9:09 am
SNA
-
GSP
8h 49m
1 stop
Delta Logo
5:42 am - 12:01 pm
GSP
-
SNA
9h 19m
1 stop
$390Delta
Thu, Apr 23 - Tue, May 5
Multiple Airlines Logo
3:22 pm - 11:26 am
SNA
-
GSP
17h 04m
1 stop
Multiple Airlines Logo
8:37 am - 10:05 am
GSP
-
SNA
52h 28m
2 stops
$396Multiple Airlines
Thu, Jul 2 - Thu, Jul 9

Delta flights from Santa Ana, California to Greenville

Our best Delta deals on Santa Ana, California to Greenville flight tickets
Delta
Apr 23
SNA9:20 pmSanta Ana J. Wayne/Orange Cnty
8h 49m
1 stop
GSP9:09 amGreenville
Apr 28
GSP5:42 amGreenville
9h 19m
1 stop
SNA12:01 pmSanta Ana J. Wayne/Orange Cnty
$331
Delta
Apr 23
SNA9:20 pmSanta Ana J. Wayne/Orange Cnty
8h 49m
1 stop
GSP9:09 amGreenville
May 5
GSP6:51 amGreenville
14h 02m
2 stops
SNA5:53 pmSanta Ana J. Wayne/Orange Cnty
$336
Delta
May 20
SNA11:53 amSanta Ana J. Wayne/Orange Cnty
6h 45m
1 stop
GSP9:38 pmGreenville
May 23
GSP5:05 pmGreenville
8h 24m
1 stop
SNA10:29 pmSanta Ana J. Wayne/Orange Cnty
$359

American Airlines flights from Santa Ana, California to Greenville

Our best American Airlines deals on Santa Ana, California to Greenville flight tickets
American Airlines
Apr 22
SNA1:23 pmSanta Ana J. Wayne/Orange Cnty
6h 17m
1 stop
GSP10:40 pmGreenville
Apr 25
GSP4:28 pmGreenville
7h 46m
1 stop
SNA9:14 pmSanta Ana J. Wayne/Orange Cnty
$346
American Airlines
Apr 22
SNA1:23 pmSanta Ana J. Wayne/Orange Cnty
6h 17m
1 stop
GSP10:40 pmGreenville
Apr 25
GSP5:20 amGreenville
9h 45m
2 stops
SNA12:05 pmSanta Ana J. Wayne/Orange Cnty
$357
American Airlines
Apr 25
SNA6:45 amSanta Ana J. Wayne/Orange Cnty
6h 36m
1 stop
GSP4:21 pmGreenville
May 2
GSP4:28 pmGreenville
7h 46m
1 stop
SNA9:14 pmSanta Ana J. Wayne/Orange Cnty
$363

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana, California to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 29, 2026.
Use the filters below to find and compare flights from Santa Ana, California to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Thu 4/23

9:20 pm-9:09 am

1 stop8h 49m

Greenville

Tue 4/28

5:42 am-12:01 pm

1 stop9h 19m

$331

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Thu 4/23

9:20 pm-9:09 am

1 stop8h 49m

Greenville

Tue 5/5

6:51 am-5:53 pm

2 stops14h 02m

$336
Quickest round-trip

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Wed 4/22

1:23 pm-10:40 pm

1 stop6h 17m

Greenville

Sat 4/25

4:28 pm-9:14 pm

1 stop7h 46m

$346

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Wed 4/22

1:23 pm-10:40 pm

1 stop6h 17m

Greenville

Sat 4/25

5:20 am-12:05 pm

2 stops9h 45m

$357

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Wed 5/20

11:53 am-9:38 pm

1 stop6h 45m

Greenville

Sat 5/23

5:05 pm-10:29 pm

1 stop8h 24m

$359

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Sat 4/25

6:45 am-4:21 pm

1 stop6h 36m

Greenville

Sat 5/2

4:28 pm-9:14 pm

1 stop7h 46m

$363

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Sat 4/25

12:15 pm-9:59 pm

1 stop6h 44m

Greenville

Sat 5/2

6:36 am-3:42 pm

2 stops12h 06m

$368

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Thu 4/23

7:00 pm-9:09 am

2 stops11h 09m

Greenville

Tue 4/28

5:42 am-5:53 pm

2 stops15h 11m

$369

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Thu 4/23

9:20 pm-9:09 am

1 stop8h 49m

Greenville

Tue 5/5

5:42 am-12:01 pm

1 stop9h 19m

$390

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Thu 7/2

3:22 pm-11:26 am

1 stop17h 04m

Greenville

Thu 7/9

8:37 am-10:05 am

2 stops52h 28m

$396

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Santa Ana, California to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santa Ana, California and Greenville?

What is the cheapest month to fly to Greenville?

The month of March is another great option to travel to Greenville, with average flight prices from Santa Ana, California averaging around $418.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Thursday is the cheapest day to fly to Greenville from Santa Ana, California. The lowest ticket price found for a Thursday departure recently was $122. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $307. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the morning. Flights from Santa Ana, California to Greenville during this time can be as low as $232. Flights to Greenville are more costly at noon, with an average ticket price of $306. Departure times at noon fall within the peak daily travel times, which is why tickets can be more expensive.

Can stopping save me money on Santa Ana, California to Greenville flights?

You could potentially save up to 10% on your flight if you consider stops on a Santa Ana, California to Greenville flight.

How have Santa Ana, California to Greenville flight prices changed over time?

When to book flights from Santa Ana, California to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana, California to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana, California to Greenville (SNA to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana, California to Greenville

Fastest flight time

6h 44m

Direct flights

None
The fastest flight from Santa Ana, California to Greenville takes 6h 44m
There are no direct flights from Santa Ana, California to Greenville. There are no popular flight routes from Santa Ana, California to Greenville.
Search flight deals

  • How far is Santa Ana J. Wayne/Orange Cnty to Greenville by plane?

    Greenville is 2014.2 mi away from Santa Ana J. Wayne/Orange Cnty. Flights usually cover this in 6h 44m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport were last updated today.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents you'll need for your trip to Greenville Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Greenville Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santa Ana, California to Greenville?

Best airlines flying from Santa Ana, California to Greenville

Compare and see reviews for airlines that fly from Santa Ana, California to Greenville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $324Free CancellationRating
7.1
11,521 reviews
Search American Airlines flights
DeltaPriceFrom $337Free CancellationRating
7.9
8,359 reviews
Search Delta flights
United AirlinesPriceFrom $389Free CancellationRating
7.4
9,509 reviews
Search United Airlines flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Greer
Seneca
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to Greenville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Santa Ana to Greenville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Santa Ana to Greenville with flexible booking policies on momondo?

Flights from Santa Ana to Greenville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Santa Ana to Greenville?

momondo helps you find the best flight between Santa Ana and Greenville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santa Ana to Greenville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Santa Ana to Greenville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Greenville and let you know when they change.

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