Which layover airport has the shortest connection time from Santa Ana to Greenville?

Chicago (ORD) has the shortest average layover time for this route: 0h 53m.

Which layover airport offers the lowest fares from Santa Ana to Greenville?

Flights via Chicago (ORD) offer the lowest average round-trip price of $505.

Which layover airport has the shortest travel time from Santa Ana to Greenville?

Flights connecting via Dallas (DFW) have the shortest average one-way travel time: 7h 04m.

What is the cheapest airline that flies from Santa Ana J. Wayne/Orange Cnty to Greenville?

United Airlines and Delta are the most popular carriers operating from Santa Ana J. Wayne/Orange Cnty to Greenville

Which airport is the most popular layover for flights between Santa Ana and Greenville?

Dallas (DFW) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

What airlines fly to Greenville?

American Airlines, Delta and Spirit Airlines are the top three most popular airlines that fly to Greenville from Santa Ana according to our data. American Airlines is the first choice among our users, with 73% of people opting to fly with this airline when traveling to Greenville. Keep in mind that there are 7 different airlines that fly to Greenville on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?

Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport were last updated today.

How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?

As of August 2025, there are 4 operators available to choose from for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport.

How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport.

What documentation or ID do you need to fly to Greenville Airport?

The travel and health documents you'll need for your trip to Greenville Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Greenville Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$176 Cheap Flights from Santa Ana to Greenville in 2025

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Round-trip

One-way

Cheap round-trip flights

6:45 am - 4:16 pmSNA-GSP

6h 31m1 stop

4:27 pm - 10:12 pmGSP-SNA

8h 45m1 stop

$297Delta

Find Deal

Sat, Sep 13 - Thu, Sep 18

8:00 am - 11:34 pmSNA-GSP

12h 34m2 stops

6:13 pm - 10:12 pmGSP-SNA

6h 59m1 stop

$302Delta

Find Deal

Sat, Sep 13 - Thu, Sep 18

11:42 am - 10:25 pmSNA-GSP

7h 43m1 stop

7:15 am - 11:57 amGSP-SNA

7h 42m1 stop

$351American Airlines

Find Deal

Thu, Oct 2 - Sat, Oct 4

9:15 am - 10:58 pmSNA-GSP

10h 43m2 stops

4:14 pm - 9:47 pmGSP-SNA

8h 33m2 stops

$383American Airlines

Find Deal

Sat, Sep 13 - Thu, Sep 18

8:25 pm - 9:45 amSNA-GSP

10h 20m2 stops

10:20 am - 7:35 pmGSP-SNA

12h 15m2 stops

$447Southwest

Find Deal

Thu, Nov 13 - Sun, Nov 16

8:30 pm - 8:34 pmSNA-GSP

21h 04m3 stops

8:06 pm - 9:21 pmGSP-SNA

28h 15m3 stops

$453

Find Deal

Wed, Aug 20 - Sun, Aug 24

6:45 am - 5:35 pmSNA-GSP

31h 50m3 stops

8:06 pm - 9:21 pmGSP-SNA

28h 15m3 stops

$455

Find Deal

Thu, Aug 21 - Sun, Aug 24

9:05 pm - 8:51 amSNA-GSP

8h 46m1 stop

4:30 pm - 8:33 pmGSP-SNA

7h 03m1 stop

$522United Airlines

Find Deal

Tue, Aug 19 - Wed, Aug 20

9:05 pm - 8:51 amSNA-GSP

8h 46m1 stop

2:51 pm - 10:30 pmGSP-SNA

10h 39m2 stops

$528United Airlines

Find Deal

Tue, Aug 19 - Wed, Aug 20

7:20 am - 9:00 pmSNA-GSP

10h 40m2 stops

10:45 am - 5:45 pmGSP-SNA

10h 00m2 stops

$587Southwest

Find Deal

Thu, Sep 18 - Mon, Sep 22

Delta flights from Santa Ana to Greenville

Our best Delta deals on Santa Ana to Greenville flight tickets

Delta

Sep 13

SNA6:45 amSanta Ana J. Wayne/Orange Cnty

6h 31m

1 stop

GSP4:16 pmGreenville

Sep 18

GSP4:27 pmGreenville

8h 45m

1 stop

SNA10:12 pmSanta Ana J. Wayne/Orange Cnty

$297

Find similar

Delta

Sep 13

SNA8:00 amSanta Ana J. Wayne/Orange Cnty

12h 34m

2 stops

GSP11:34 pmGreenville

Sep 18

GSP6:13 pmGreenville

6h 59m

1 stop

SNA10:12 pmSanta Ana J. Wayne/Orange Cnty

$302

Find similar

Delta

Sep 21

SNA9:20 pmSanta Ana J. Wayne/Orange Cnty

8h 53m

1 stop

GSP9:13 amGreenville

Sep 25

GSP4:27 pmGreenville

8h 45m

1 stop

SNA10:12 pmSanta Ana J. Wayne/Orange Cnty

$324

Find similar

American Airlines flights from Santa Ana to Greenville

Our best American Airlines deals on Santa Ana to Greenville flight tickets

American Airlines

Oct 2

SNA11:42 amSanta Ana J. Wayne/Orange Cnty

7h 43m

1 stop

GSP10:25 pmGreenville

Oct 4

GSP7:15 amGreenville

7h 42m

1 stop

SNA11:57 amSanta Ana J. Wayne/Orange Cnty

$351

Find similar

American Airlines

Sep 13

SNA9:15 amSanta Ana J. Wayne/Orange Cnty

10h 43m

2 stops

GSP10:58 pmGreenville

Sep 18

GSP4:14 pmGreenville

8h 33m

2 stops

SNA9:47 pmSanta Ana J. Wayne/Orange Cnty

$383

Find similar

American Airlines

Nov 13

SNA7:55 amSanta Ana J. Wayne/Orange Cnty

8h 49m

1 stop

GSP7:44 pmGreenville

Nov 16

GSP6:12 amGreenville

7h 30m

1 stop

SNA10:42 amSanta Ana J. Wayne/Orange Cnty

$427

Find similar

Fly from

Fly to

Route

Depart

Return

Price

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Sat 9/13

6:45 am-4:16 pm

1 stop6h 31m

Greenville

Thu 9/18

4:27 pm-10:12 pm

1 stop8h 45m

$297

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Sat 9/13

8:00 am-11:34 pm

2 stops12h 34m

Greenville

Thu 9/18

6:13 pm-10:12 pm

1 stop6h 59m

$302

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Thu 10/2

11:42 am-10:25 pm

1 stop7h 43m

Greenville

Sat 10/4

7:15 am-11:57 am

1 stop7h 42m

$351

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Sat 9/13

9:15 am-10:58 pm

2 stops10h 43m

Greenville

Thu 9/18

4:14 pm-9:47 pm

2 stops8h 33m

$383

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Thu 11/13

8:25 pm-9:45 am

2 stops10h 20m

Greenville

Sun 11/16

10:20 am-7:35 pm

2 stops12h 15m

$447

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Wed 8/20

8:30 pm-8:34 pm

3 stops21h 04m

Greenville

Sun 8/24

8:06 pm-9:21 pm

3 stops28h 15m

$453

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Thu 8/21

6:45 am-5:35 pm

3 stops31h 50m

Greenville

Sun 8/24

8:06 pm-9:21 pm

3 stops28h 15m

$455

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 8/19

9:05 pm-8:51 am

1 stop8h 46m

Greenville

Wed 8/20

4:30 pm-8:33 pm

1 stop7h 03m

$522

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 8/19

9:05 pm-8:51 am

1 stop8h 46m

Greenville

Wed 8/20

2:51 pm-10:30 pm

2 stops10h 39m

$528

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Thu 9/18

7:20 am-9:00 pm

2 stops10h 40m

Greenville

Mon 9/22

10:45 am-5:45 pm

2 stops10h 00m

$587

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first

How to get the cheapest flight ticket from Santa Ana to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the cheapest month to fly to Greenville?

The month of July is another great option to travel to Greenville, with average flight prices from Santa Ana averaging around $387.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Thursday is the cheapest day to fly to Greenville from Santa Ana. The lowest ticket price found for a Thursday departure recently was $122. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $307. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the morning. Flights from Santa Ana to Greenville during this time can be as low as $212. Flights to Greenville are more costly in the evening, with an average ticket price of $439. Departure times in the evening fall within the peak daily travel times, which is why tickets can be more expensive.

How have Santa Ana to Greenville flight prices changed over time?

When to book flights from Santa Ana to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana to Greenville according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Santa Ana to Greenville (SNA to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana to Greenville

Best Price Found	$176
Fastest flight time	6h 31m
Direct flights	None
Airports in Greenville	1 airport

The best one-way flight to Greenville from Santa Ana in the past 72 hours is $176. The best round-trip flight deal from Santa Ana to Greenville found on momondo in the last 72 hours is $297.

The fastest flight from Santa Ana to Greenville takes 6h 31m

There are no direct flights from Santa Ana to Greenville. Popular non-direct route for this connection is Santa Ana J. Wayne/Orange Cnty Airport - Greenville Airport.

There is 1 airport near Greenville: Greenville (GSP)

Search flight deals

How far is Santa Ana J. Wayne/Orange Cnty to Greenville by plane?
Greenville is 2014.2 mi away from Santa Ana J. Wayne/Orange Cnty. Flights usually cover this in 6h 31m, depending on flying conditions and air traffic around both airports.
When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?
Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport were last updated today.
How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?
As of August 2025, there are 4 operators available to choose from for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport.
How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport.
What documentation or ID do you need to fly to Greenville Airport?
The travel and health documents you'll need for your trip to Greenville Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Greenville Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Santa Ana to Greenville?
Based on momondo bookings for flights between Santa Ana and Greenville, the leading airline is American Airlines, making up 62% of the total bookings. Other popular airlines include Delta with 21%, United Airlines with 12%, and Southwest with 5%.

Best airlines flying from Santa Ana to Greenville

Compare and see reviews for airlines that fly from Santa Ana to Greenville with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $336	Free Cancellation	Rating 7.2 10,000 reviews	Search American Airlines flights
United Airlines	PriceFrom $361	Free Cancellation	Rating 7.4 8,917 reviews	Search United Airlines flights
Delta	PriceFrom $377	Free Cancellation	Rating 8.0 7,985 reviews	Search Delta flights
Southwest	PriceFrom $388	Free Cancellation	Rating 8.0 4,244 reviews	Search Southwest flights

Anderson

Simpsonville

Greenwood

Seneca

Greer

Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to Greenville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Santa Ana to Greenville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Santa Ana to Greenville with flexible booking policies on momondo?

Flights from Santa Ana to Greenville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Santa Ana to Greenville?

momondo helps you find the best flight between Santa Ana and Greenville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santa Ana to Greenville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Santa Ana to Greenville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Greenville and let you know when they change.

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Cheap flights from Santa Ana to Greenville from $176

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana to Greenville departing on 12/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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Find the cheapest flights from Santa Ana to Greenville

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Delta flights from Santa Ana to Greenville

Our best Delta deals on Santa Ana to Greenville flight tickets

American Airlines flights from Santa Ana to Greenville

Our best American Airlines deals on Santa Ana to Greenville flight tickets

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See travel insights to Greenville from

How to get the cheapest flight ticket from Santa Ana to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Greenville?

The month of July is another great option to travel to Greenville, with average flight prices from Santa Ana averaging around $387.

What is the cheapest day to depart on your flight to Greenville?

What is the cheapest time of day to depart on your flight to Greenville?

How have Santa Ana to Greenville flight prices changed over time?

What is the cheapest airline that flies from Santa Ana J. Wayne/Orange Cnty to Greenville?

United Airlines and Delta are the most popular carriers operating from Santa Ana J. Wayne/Orange Cnty to Greenville

What airlines fly to Greenville?

Which airport is the most popular layover for flights between Santa Ana and Greenville?

Dallas (DFW) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport offers the lowest fares from Santa Ana to Greenville?

Flights via Chicago (ORD) offer the lowest average round-trip price of $505.

Which layover airport has the shortest travel time from Santa Ana to Greenville?

Flights connecting via Dallas (DFW) have the shortest average one-way travel time: 7h 04m.

Which layover airport has the shortest connection time from Santa Ana to Greenville?

Chicago (ORD) has the shortest average layover time for this route: 0h 53m.

When to book flights from Santa Ana to Greenville

Cheap Santa Ana to Greenville (SNA to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana to Greenville

Best Price Found

Fastest flight time

Direct flights

Airports in Greenville

How far is Santa Ana J. Wayne/Orange Cnty to Greenville by plane?

When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?

How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?

How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?

What documentation or ID do you need to fly to Greenville Airport?

What is the most popular airline from Santa Ana to Greenville?

Best airlines flying from Santa Ana to Greenville

Compare and see reviews for airlines that fly from Santa Ana to Greenville with momondo

Traveling to a place near Greenville?

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to Greenville?

Can I find flights from Santa Ana to Greenville with flexible booking policies on momondo?

How can momondo help me find flights from Santa Ana to Greenville?

I’m not ready to book a flight from Santa Ana to Greenville right now. Can momondo alert me if prices change?

An easier way to manage your Greenville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to the United States

Airports servicing South Carolina