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Cheap flights from Santa Ana to Greenville from $156

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana to Greenville departing on 3/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Santa Ana to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
11:41 am - 11:39 pm
SNA
-
GSP
8h 58m
1 stop
American Airlines Logo
4:30 pm - 10:45 pm
GSP
-
SNA
9h 15m
1 stop
$419American Airlines
Tue, Mar 17 - Mon, Mar 23
Delta Logo
2:00 pm - 11:53 pm
SNA
-
GSP
6h 53m
1 stop
Delta Logo
8:45 am - 12:50 pm
GSP
-
SNA
7h 05m
1 stop
$420Delta
Thu, May 7 - Sun, May 10
American Airlines Logo
7:48 pm - 8:38 am
SNA
-
GSP
9h 50m
2 stops
American Airlines Logo
4:30 pm - 10:45 pm
GSP
-
SNA
9h 15m
1 stop
$425American Airlines
Tue, Mar 17 - Mon, Mar 23
Delta Logo
11:48 am - 9:38 pm
SNA
-
GSP
6h 50m
1 stop
Delta Logo
8:45 am - 12:50 pm
GSP
-
SNA
7h 05m
1 stop
$447Delta
Fri, May 8 - Sun, May 10
Delta Logo
5:11 pm - 9:02 am
SNA
-
GSP
12h 51m
2 stops
Delta Logo
8:45 am - 12:50 pm
GSP
-
SNA
7h 05m
1 stop
$452Delta
Fri, May 8 - Sun, May 10
Southwest Logo
10:35 am - 10:45 pm
SNA
-
GSP
9h 10m
2 stops
Southwest Logo
1:55 pm - 10:25 pm
GSP
-
SNA
11h 30m
2 stops
$466Southwest
Fri, Mar 13 - Mon, Mar 16
United Airlines Logo
12:15 pm - 9:59 pm
SNA
-
GSP
6h 44m
1 stop
United Airlines Logo
4:10 pm - 9:58 pm
GSP
-
SNA
8h 48m
1 stop
$480United Airlines
Wed, Apr 8 - Mon, Apr 13
Delta Logo
11:55 am - 9:25 pm
SNA
-
GSP
6h 30m
1 stop
Delta Logo
5:05 pm - 10:18 pm
GSP
-
SNA
8h 13m
1 stop
$506Delta
Thu, Jun 25 - Mon, Jun 29
United Airlines Logo
10:50 am - 8:47 pm
SNA
-
GSP
6h 57m
1 stop
United Airlines Logo
4:10 pm - 8:47 pm
GSP
-
SNA
7h 37m
1 stop
$507United Airlines
Wed, Apr 8 - Wed, Apr 15
Delta Logo
7:05 pm - 10:28 am
SNA
-
GSP
12h 23m
2 stops
Delta Logo
5:05 pm - 10:24 pm
GSP
-
SNA
8h 19m
1 stop
$511Delta
Mon, Jul 6 - Tue, Jul 14

Delta flights from Santa Ana to Greenville

Our best Delta deals on Santa Ana to Greenville flight tickets
Delta
May 7
SNA2:00 pmSanta Ana J. Wayne/Orange Cnty
6h 53m
1 stop
GSP11:53 pmGreenville
May 10
GSP8:45 amGreenville
7h 05m
1 stop
SNA12:50 pmSanta Ana J. Wayne/Orange Cnty
$420
Delta
May 8
SNA12:20 pmSanta Ana J. Wayne/Orange Cnty
8h 33m
1 stop
GSP11:53 pmGreenville
May 10
GSP8:45 amGreenville
7h 05m
1 stop
SNA12:50 pmSanta Ana J. Wayne/Orange Cnty
$447
Delta
May 8
SNA5:11 pmSanta Ana J. Wayne/Orange Cnty
12h 51m
2 stops
GSP9:02 amGreenville
May 10
GSP8:45 amGreenville
7h 05m
1 stop
SNA12:50 pmSanta Ana J. Wayne/Orange Cnty
$452

Southwest flights from Santa Ana to Greenville

Our best Southwest deals on Santa Ana to Greenville flight tickets
Southwest
Mar 13
SNA10:35 amSanta Ana J. Wayne/Orange Cnty
9h 10m
2 stops
GSP10:45 pmGreenville
Mar 16
GSP1:55 pmGreenville
11h 30m
2 stops
SNA10:25 pmSanta Ana J. Wayne/Orange Cnty
$466
Southwest
May 8
SNA8:35 amSanta Ana J. Wayne/Orange Cnty
10h 40m
2 stops
GSP10:15 pmGreenville
May 10
GSP6:30 amGreenville
10h 30m
2 stops
SNA2:00 pmSanta Ana J. Wayne/Orange Cnty
$517
Southwest
May 7
SNA10:25 amSanta Ana J. Wayne/Orange Cnty
8h 50m
2 stops
GSP10:15 pmGreenville
May 10
GSP6:30 amGreenville
10h 30m
2 stops
SNA2:00 pmSanta Ana J. Wayne/Orange Cnty
$539

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 9, 2026.
Use the filters below to find and compare flights from Santa Ana to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 3/17

11:41 am-11:39 pm

1 stop8h 58m

Greenville

Mon 3/23

4:30 pm-10:45 pm

1 stop9h 15m

$419

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Thu 5/7

2:00 pm-11:53 pm

1 stop6h 53m

Greenville

Sun 5/10

8:45 am-12:50 pm

1 stop7h 05m

$420

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 3/17

7:48 pm-8:38 am

2 stops9h 50m

Greenville

Mon 3/23

4:30 pm-10:45 pm

1 stop9h 15m

$425

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Fri 5/8

11:48 am-9:38 pm

1 stop6h 50m

Greenville

Sun 5/10

8:45 am-12:50 pm

1 stop7h 05m

$447

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Fri 5/8

5:11 pm-9:02 am

2 stops12h 51m

Greenville

Sun 5/10

8:45 am-12:50 pm

1 stop7h 05m

$452

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Fri 3/13

10:35 am-10:45 pm

2 stops9h 10m

Greenville

Mon 3/16

1:55 pm-10:25 pm

2 stops11h 30m

$466

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Wed 4/8

12:15 pm-9:59 pm

1 stop6h 44m

Greenville

Mon 4/13

4:10 pm-9:58 pm

1 stop8h 48m

$480

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Thu 6/25

11:55 am-9:25 pm

1 stop6h 30m

Greenville

Mon 6/29

5:05 pm-10:18 pm

1 stop8h 13m

$506

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Wed 4/8

10:50 am-8:47 pm

1 stop6h 57m

Greenville

Wed 4/15

4:10 pm-8:47 pm

1 stop7h 37m

$507

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Mon 7/6

7:05 pm-10:28 am

2 stops12h 23m

Greenville

Tue 7/14

5:05 pm-10:24 pm

1 stop8h 19m

$511

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Santa Ana to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Greenville?

The month of September is another great option to travel to Greenville, with average flight prices from Santa Ana averaging around $424.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Thursday is the cheapest day to fly to Greenville from Santa Ana. The lowest ticket price found for a Thursday departure recently was $122. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $307. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the morning. Flights from Santa Ana to Greenville during this time can be as low as $227. Flights to Greenville are more costly at noon, with an average ticket price of $304. Departure times at noon fall within the peak daily travel times, which is why tickets can be more expensive.

Can stopping save me money on Santa Ana to Greenville flights?

You could potentially save up to 15% on your flight if you consider stops on a Santa Ana to Greenville flight.

How have Santa Ana to Greenville flight prices changed over time?

When to book flights from Santa Ana to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana to Greenville (SNA to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana to Greenville

Fastest flight time

6h 24m

Direct flights

None
The fastest flight from Santa Ana to Greenville takes 6h 24m
There are no direct flights from Santa Ana to Greenville. There are no popular flight routes from Santa Ana to Greenville.
Search flight deals

  • How far is Santa Ana J. Wayne/Orange Cnty to Greenville by plane?

    Greenville is 2014.2 mi away from Santa Ana J. Wayne/Orange Cnty. Flights usually cover this in 6h 24m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport were last updated today.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents you'll need for your trip to Greenville Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Greenville Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santa Ana to Greenville?

Best airlines flying from Santa Ana to Greenville

Compare and see reviews for airlines that fly from Santa Ana to Greenville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $324Free CancellationRating
7.2
11,255 reviews
Search American Airlines flights
DeltaPriceFrom $337Free CancellationRating
7.9
8,173 reviews
Search Delta flights
United AirlinesPriceFrom $434Free CancellationRating
7.4
9,257 reviews
Search United Airlines flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Seneca
Greer
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to Greenville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Santa Ana to Greenville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Santa Ana to Greenville with flexible booking policies on momondo?

Flights from Santa Ana to Greenville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Santa Ana to Greenville?

momondo helps you find the best flight between Santa Ana and Greenville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santa Ana to Greenville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Santa Ana to Greenville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Greenville and let you know when they change.

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