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Cheap flights from Santa Ana, California to Greenville from $173

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Santa Ana, California to Greenville departing on 5/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Santa Ana, California to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
12:15 pm - 10:00 pm
SNA
-
GSP
6h 45m
1 stop
Delta Logo
2:25 pm - 6:20 pm
GSP
-
SNA
6h 55m
1 stop
$395Delta
Tue, Sep 22 - Tue, Sep 29
American Airlines Logo
1:01 pm - 10:56 pm
SNA
-
GSP
6h 55m
1 stop
American Airlines Logo
6:30 am - 10:55 am
GSP
-
SNA
7h 25m
1 stop
$407American Airlines
Wed, Jun 24 - Tue, Jun 30
Delta Logo
12:15 pm - 10:00 pm
SNA
-
GSP
6h 45m
1 stop
Delta Logo
2:25 pm - 6:20 pm
GSP
-
SNA
6h 55m
1 stop
$408Delta
Wed, Sep 23 - Mon, Sep 28
Delta Logo
6:51 pm - 10:55 am
SNA
-
GSP
13h 04m
2 stops
Delta Logo
5:16 pm - 10:28 pm
GSP
-
SNA
8h 12m
1 stop
$413Delta
Mon, Jun 1 - Tue, Jun 9
United Airlines Logo
7:49 pm - 9:55 am
SNA
-
GSP
11h 06m
2 stops
United Airlines Logo
4:15 pm - 8:40 pm
GSP
-
SNA
7h 25m
1 stop
$417United Airlines
Tue, Jun 9 - Wed, Jun 17
Southwest Logo
11:10 am - 10:00 pm
SNA
-
GSP
7h 50m
2 stops
Southwest Logo
7:00 am - 2:10 pm
GSP
-
SNA
10h 10m
2 stops
$418Southwest
Wed, Jul 1 - Tue, Jul 7
Delta Logo
12:15 pm - 10:00 pm
SNA
-
GSP
6h 45m
1 stop
Delta Logo
3:42 pm - 10:14 pm
GSP
-
SNA
9h 32m
1 stop
$421Delta
Thu, Sep 24 - Sat, Sep 26
Delta Logo
12:18 pm - 11:59 pm
SNA
-
GSP
8h 41m
1 stop
Delta Logo
3:06 pm - 7:00 pm
GSP
-
SNA
6h 54m
1 stop
$431Delta
Fri, Jul 3 - Wed, Jul 8
American Airlines Logo
6:45 am - 7:24 pm
SNA
-
GSP
9h 39m
1 stop
American Airlines Logo
6:29 am - 12:11 pm
GSP
-
SNA
8h 42m
1 stop
$433American Airlines
Tue, Jun 2 - Wed, Jun 3
Southwest Logo
11:05 am - 10:00 pm
SNA
-
GSP
7h 55m
2 stops
Southwest Logo
7:00 am - 2:10 pm
GSP
-
SNA
10h 10m
2 stops
$441Southwest
Tue, Jun 9 - Wed, Jun 17

American Airlines flights from Santa Ana, California to Greenville

Our best American Airlines deals on Santa Ana, California to Greenville flight tickets
American Airlines
Jun 24
SNA1:01 pmSanta Ana J. Wayne/Orange Cnty
6h 55m
1 stop
GSP10:56 pmGreenville
Jun 30
GSP6:30 amGreenville
7h 25m
1 stop
SNA10:55 amSanta Ana J. Wayne/Orange Cnty
$407
American Airlines
Jun 2
SNA6:45 amSanta Ana J. Wayne/Orange Cnty
9h 39m
1 stop
GSP7:24 pmGreenville
Jun 3
GSP6:29 amGreenville
8h 42m
1 stop
SNA12:11 pmSanta Ana J. Wayne/Orange Cnty
$433
American Airlines
May 27
SNA1:01 pmSanta Ana J. Wayne/Orange Cnty
6h 56m
1 stop
GSP10:57 pmGreenville
Jun 4
GSP6:30 amGreenville
8h 41m
1 stop
SNA12:11 pmSanta Ana J. Wayne/Orange Cnty
$484

United Airlines flights from Santa Ana, California to Greenville

Our best United Airlines deals on Santa Ana, California to Greenville flight tickets
United Airlines
Jun 9
SNA7:49 pmSanta Ana J. Wayne/Orange Cnty
11h 06m
2 stops
GSP9:55 amGreenville
Jun 17
GSP4:15 pmGreenville
7h 25m
1 stop
SNA8:40 pmSanta Ana J. Wayne/Orange Cnty
$417
United Airlines
Jul 25
SNA7:49 pmSanta Ana J. Wayne/Orange Cnty
11h 06m
2 stops
GSP9:55 amGreenville
Jul 28
GSP4:15 pmGreenville
7h 25m
1 stop
SNA8:40 pmSanta Ana J. Wayne/Orange Cnty
$448
United Airlines
May 27
SNA7:45 amSanta Ana J. Wayne/Orange Cnty
10h 32m
2 stops
GSP9:17 pmGreenville
Jun 4
GSP4:15 pmGreenville
8h 46m
1 stop
SNA10:01 pmSanta Ana J. Wayne/Orange Cnty
$503

momondo Fare Finder

 
Customize your flight search to find flights from Santa Ana, California to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 14, 2026.
Use the filters below to find and compare flights from Santa Ana, California to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 9/22

12:15 pm-10:00 pm

1 stop6h 45m

Greenville

Tue 9/29

2:25 pm-6:20 pm

1 stop6h 55m

$395

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Wed 6/24

1:01 pm-10:56 pm

1 stop6h 55m

Greenville

Tue 6/30

6:30 am-10:55 am

1 stop7h 25m

$407

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Wed 9/23

12:15 pm-10:00 pm

1 stop6h 45m

Greenville

Mon 9/28

2:25 pm-6:20 pm

1 stop6h 55m

$408

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Mon 6/1

6:51 pm-10:55 am

2 stops13h 04m

Greenville

Tue 6/9

5:16 pm-10:28 pm

1 stop8h 12m

$413

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 6/9

7:49 pm-9:55 am

2 stops11h 06m

Greenville

Wed 6/17

4:15 pm-8:40 pm

1 stop7h 25m

$417

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Wed 7/1

11:10 am-10:00 pm

2 stops7h 50m

Greenville

Tue 7/7

7:00 am-2:10 pm

2 stops10h 10m

$418

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Thu 9/24

12:15 pm-10:00 pm

1 stop6h 45m

Greenville

Sat 9/26

3:42 pm-10:14 pm

1 stop9h 32m

$421

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Fri 7/3

12:18 pm-11:59 pm

1 stop8h 41m

Greenville

Wed 7/8

3:06 pm-7:00 pm

1 stop6h 54m

$431

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 6/2

6:45 am-7:24 pm

1 stop9h 39m

Greenville

Wed 6/3

6:29 am-12:11 pm

1 stop8h 42m

$433

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Tue 6/9

11:05 am-10:00 pm

2 stops7h 55m

Greenville

Wed 6/17

7:00 am-2:10 pm

2 stops10h 10m

$441

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Santa Ana, California to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Santa Ana, California and Greenville?

What is the cheapest month to fly to Greenville?

The month of March is another great option to travel to Greenville, with average flight prices from Santa Ana, California averaging around $389.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Thursday is the cheapest day to fly to Greenville from Santa Ana, California. The lowest ticket price found for a Thursday departure recently was $122. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $333. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the morning. Flights from Santa Ana, California to Greenville during this time can be as low as $245. Flights to Greenville are more costly at noon, with an average ticket price of $307. Departure times at noon fall within the peak daily travel times, which is why tickets can be more expensive.

Can stopping save me money on Santa Ana, California to Greenville flights?

You could potentially save up to 6% on your flight if you consider stops on a Santa Ana, California to Greenville flight.

How have Santa Ana, California to Greenville flight prices changed over time?

When to book flights from Santa Ana, California to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana, California to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Santa Ana, California to Greenville (SNA to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana, California to Greenville

Fastest flight time

6h 16m

Direct flights

None
The fastest flight from Santa Ana, California to Greenville takes 6h 16m
There are no direct flights from Santa Ana, California to Greenville. There are no popular flight routes from Santa Ana, California to Greenville.
Search flight deals

Frequently asked questions about flying from Santa Ana, California to Greenville

  • How far is Santa Ana J. Wayne/Orange Cnty to Greenville by plane?

    Greenville is 2014.2 mi away from Santa Ana J. Wayne/Orange Cnty. Flights usually cover this in 6h 16m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?

    Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport were last updated today.

  • How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?

  • How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents you'll need for your trip to Greenville Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Greenville Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Santa Ana, California to Greenville?

Best airlines flying from Santa Ana, California to Greenville

Compare and see reviews for airlines that fly from Santa Ana, California to Greenville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $324Free CancellationRating
7.1
11,664 reviews
Search American Airlines flights
United AirlinesPriceFrom $336Free CancellationRating
7.4
9,711 reviews
Search United Airlines flights
DeltaPriceFrom $337Free CancellationRating
7.9
8,454 reviews
Search Delta flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Greer
Seneca
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to Greenville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Santa Ana to Greenville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Santa Ana to Greenville with flexible booking policies on momondo?

Flights from Santa Ana to Greenville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Santa Ana to Greenville?

momondo helps you find the best flight between Santa Ana and Greenville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santa Ana to Greenville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Santa Ana to Greenville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Greenville and let you know when they change.

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