What airlines fly to Greenville?

American Airlines, Delta and Spirit Airlines are the top three most popular airlines that fly to Greenville from Santa Ana, California according to our data. American Airlines is the first choice among our users, with 74% of people opting to fly with this airline when traveling to Greenville. Keep in mind that there are 7 different airlines that fly to Greenville on a routine basis, so you have a few additional options to choose from.

Which layover airport has the shortest connection time from Santa Ana, California to Greenville?

Chicago (ORD) has the shortest average layover time for this route: 0h 53m.

Which layover airport offers the lowest fares from Santa Ana, California to Greenville?

Flights via Chicago (ORD) offer the lowest average round-trip price of $505.

What is the cheapest airline that flies from Santa Ana J. Wayne/Orange Cnty to Greenville?

American Airlines, Delta, and Southwest are the most popular carriers operating from Santa Ana J. Wayne/Orange Cnty to Greenville

Which layover airport has the shortest travel time from Santa Ana, California to Greenville?

Flights connecting via Dallas (DFW) have the shortest average one-way travel time: 7h 04m.

Which airport is the most popular layover for flights between Santa Ana, California and Greenville?

Dallas (DFW) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?

Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport were last updated today.

How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?

As of October 2025, there are 3 operators available to choose from for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport.

How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport.

What documentation or ID do you need to fly to Greenville Airport?

The travel and health documents you'll need for your trip to Greenville Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Greenville Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$180 Cheap Flights from Santa Ana to Greenville in 2025/26

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11:41 am - 10:01 pmSNA-GSP

7h 20m1 stop

12:02 pm - 5:59 pmGSP-SNA

8h 57m1 stop

$386American Airlines

Find Deal

qui, dez 4 - sex, dez 5

12:28 pm - 11:57 pmSNA-GSP

8h 29m2 stops

1:50 pm - 7:52 pmGSP-SNA

9h 02m1 stop

$391American Airlines

Find Deal

qui, dez 4 - sex, dez 5

12:28 pm - 11:57 pmSNA-GSP

8h 29m2 stops

6:01 am - 12:38 pmGSP-SNA

9h 37m2 stops

$423American Airlines

Find Deal

qui, dez 4 - sex, dez 5

9:20 pm - 9:02 amSNA-GSP

8h 42m1 stop

5:35 am - 1:00 pmGSP-SNA

10h 25m2 stops

$444Delta

Find Deal

dom, nov 23 - qua, dez 3

12:15 pm - 11:28 pmSNA-GSP

8h 13m1 stop

6:46 am - 11:30 amGSP-SNA

7h 44m1 stop

$447United Airlines

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qui, abr 2 - dom, abr 5

8:00 am - 11:59 pmSNA-GSP

12h 59m2 stops

6:50 am - 11:30 amGSP-SNA

7h 40m1 stop

$452United Airlines

Find Deal

seg, mar 2 - sáb, mar 21

7:15 am - 4:57 pmSNA-GSP

6h 42m1 stop

7:37 am - 1:08 pmGSP-SNA

8h 31m1 stop

$459American Airlines

Find Deal

ter, mar 3 - qua, mar 4

6:00 pm - 10:40 amSNA-GSP

13h 40m2 stops

12:35 pm - 8:30 pmGSP-SNA

10h 55m2 stops

$487Southwest

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seg, mar 2 - sáb, mar 21

7:05 pm - 10:05 amSNA-GSP

12h 00m2 stops

7:40 am - 3:35 pmGSP-SNA

10h 55m2 stops

$523Southwest

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sáb, dez 27 - qui, jan 1

7:15 am - 11:36 pmSNA-GSP

13h 21m2 stops

10:14 am - 6:17 pmGSP-SNA

11h 03m2 stops

$529Delta

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ter, mar 3 - qua, mar 4

American Airlines flights from Santa Ana, California to Greenville

Our best American Airlines deals on Santa Ana, California to Greenville flight tickets

American Airlines

Dec 4

SNA11:41 amSanta Ana J. Wayne/Orange Cnty

7h 20m

1 stop

GSP10:01 pmGreenville

Dec 5

GSP12:02 pmGreenville

8h 57m

1 stop

SNA5:59 pmSanta Ana J. Wayne/Orange Cnty

$386

Find similar

American Airlines

Dec 4

SNA12:28 pmSanta Ana J. Wayne/Orange Cnty

8h 29m

2 stops

GSP11:57 pmGreenville

Dec 5

GSP1:50 pmGreenville

9h 02m

1 stop

SNA7:52 pmSanta Ana J. Wayne/Orange Cnty

$391

Find similar

American Airlines

Dec 4

SNA12:28 pmSanta Ana J. Wayne/Orange Cnty

8h 29m

2 stops

GSP11:57 pmGreenville

Dec 5

GSP6:01 amGreenville

9h 37m

2 stops

SNA12:38 pmSanta Ana J. Wayne/Orange Cnty

$423

Find similar

Delta flights from Santa Ana, California to Greenville

Our best Delta deals on Santa Ana, California to Greenville flight tickets

Delta

Nov 23

SNA9:20 pmSanta Ana J. Wayne/Orange Cnty

8h 42m

1 stop

GSP9:02 amGreenville

Dec 3

GSP5:35 amGreenville

10h 25m

2 stops

SNA1:00 pmSanta Ana J. Wayne/Orange Cnty

$444

Find similar

Delta

Mar 3

SNA7:15 amSanta Ana J. Wayne/Orange Cnty

13h 21m

2 stops

GSP11:36 pmGreenville

Mar 4

GSP10:14 amGreenville

11h 03m

2 stops

SNA6:17 pmSanta Ana J. Wayne/Orange Cnty

$529

Find similar

Delta

Nov 23

SNA9:20 pmSanta Ana J. Wayne/Orange Cnty

8h 42m

1 stop

GSP9:02 amGreenville

Nov 26

GSP5:16 pmGreenville

8h 03m

1 stop

SNA10:19 pmSanta Ana J. Wayne/Orange Cnty

$569

Find similar

momondo Fare Finder

Use the filters below to find and compare flights from Santa Ana, California to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

qui 12/4

11:41 am-10:01 pm

1 stop7h 20m

Greenville

sex 12/5

12:02 pm-5:59 pm

1 stop8h 57m

$386

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

qui 12/4

12:28 pm-11:57 pm

2 stops8h 29m

Greenville

sex 12/5

1:50 pm-7:52 pm

1 stop9h 02m

$391

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

qui 12/4

12:28 pm-11:57 pm

2 stops8h 29m

Greenville

sex 12/5

6:01 am-12:38 pm

2 stops9h 37m

$423

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

dom 11/23

9:20 pm-9:02 am

1 stop8h 42m

Greenville

qua 12/3

5:35 am-1:00 pm

2 stops10h 25m

$444

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

qui 4/2

12:15 pm-11:28 pm

1 stop8h 13m

Greenville

dom 4/5

6:46 am-11:30 am

1 stop7h 44m

$447

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

seg 3/2

8:00 am-11:59 pm

2 stops12h 59m

Greenville

sáb 3/21

6:50 am-11:30 am

1 stop7h 40m

$452

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

ter 3/3

7:15 am-4:57 pm

1 stop6h 42m

Greenville

qua 3/4

7:37 am-1:08 pm

1 stop8h 31m

$459

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

seg 3/2

6:00 pm-10:40 am

2 stops13h 40m

Greenville

sáb 3/21

12:35 pm-8:30 pm

2 stops10h 55m

$487

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

sáb 12/27

7:05 pm-10:05 am

2 stops12h 00m

Greenville

qui 1/1

7:40 am-3:35 pm

2 stops10h 55m

$523

Santa AnaGreenville

SNA - GSP

SNAGSP

Santa Ana J. Wayne/Orange Cnty

ter 3/3

7:15 am-11:36 pm

2 stops13h 21m

Greenville

qua 3/4

10:14 am-6:17 pm

2 stops11h 03m

$529

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Santa Ana, California to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Layovers

What is the cheapest month to fly to Greenville?

The month of September is another great option to travel to Greenville, with average flight prices from Santa Ana, California averaging around $424.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Thursday is the cheapest day to fly to Greenville from Santa Ana, California. The lowest ticket price found for a Thursday departure recently was $122. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $294. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the morning. Flights from Santa Ana, California to Greenville during this time can be as low as $224. Flights to Greenville are more costly in the evening, with an average ticket price of $439. Departure times in the evening fall within the peak daily travel times, which is why tickets can be more expensive.

Can stopping save me money on Santa Ana, California to Greenville flights?

You could potentially save up to 53% on your flight if you consider stops on a Santa Ana, California to Greenville flight.

How have Santa Ana, California to Greenville flight prices changed over time?

When to book flights from Santa Ana, California to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Santa Ana, California to Greenville according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Santa Ana, California to Greenville (SNA to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana, California to Greenville

Direct flights	None

There are no direct flights from Santa Ana, California to Greenville. There are no popular flight routes from Santa Ana, California to Greenville.

Search flight deals

How far is Santa Ana J. Wayne/Orange Cnty to Greenville by plane?
Greenville is 2014.2 mi away from Santa Ana J. Wayne/Orange Cnty. Flights usually cover this in 6h 17m, depending on flying conditions and air traffic around both airports.
When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?
Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport were last updated today.
How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?
As of October 2025, there are 3 operators available to choose from for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport.
How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport.
What documentation or ID do you need to fly to Greenville Airport?
The travel and health documents you'll need for your trip to Greenville Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Greenville Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.
What is the most popular airline from Santa Ana, California to Greenville?
Based on momondo bookings for flights between Santa Ana, California and Greenville, the leading airline is American Airlines, making up 59% of the total bookings. Other popular airlines include Delta with 28% and United Airlines with 13%.

Best airlines flying from Santa Ana, California to Greenville

Compare and see reviews for airlines that fly from Santa Ana, California to Greenville with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $336	Free Cancellation	Rating 7.2 11,032 reviews	Search American Airlines flights
Delta	PriceFrom $337	Free Cancellation	Rating 7.9 7,994 reviews	Search Delta flights
United Airlines	PriceFrom $426	Free Cancellation	Rating 7.4 9,001 reviews	Search United Airlines flights

Anderson

Simpsonville

Greenwood

Seneca

Greer

Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to Greenville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Santa Ana to Greenville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Santa Ana to Greenville with flexible booking policies on momondo?

Flights from Santa Ana to Greenville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Santa Ana to Greenville?

momondo helps you find the best flight between Santa Ana and Greenville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santa Ana to Greenville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Santa Ana to Greenville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Greenville and let you know when they change.

An easier way to manage your Greenville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

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Cheap flights from Santa Ana, California to Greenville from $180

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Find the cheapest flights from Santa Ana, California to Greenville

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American Airlines flights from Santa Ana, California to Greenville

Our best American Airlines deals on Santa Ana, California to Greenville flight tickets

Delta flights from Santa Ana, California to Greenville

Our best Delta deals on Santa Ana, California to Greenville flight tickets

momondo Fare Finder

Use the filters below to find and compare flights from Santa Ana, California to Greenville that are best for you.

See travel insights to Greenville from

How to get the cheapest flight ticket from Santa Ana, California to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Greenville?

The month of September is another great option to travel to Greenville, with average flight prices from Santa Ana, California averaging around $424.

What is the cheapest day to depart on your flight to Greenville?

What is the cheapest time of day to depart on your flight to Greenville?

Can stopping save me money on Santa Ana, California to Greenville flights?

You could potentially save up to 53% on your flight if you consider stops on a Santa Ana, California to Greenville flight.

How have Santa Ana, California to Greenville flight prices changed over time?

What is the cheapest airline that flies from Santa Ana J. Wayne/Orange Cnty to Greenville?

American Airlines, Delta, and Southwest are the most popular carriers operating from Santa Ana J. Wayne/Orange Cnty to Greenville

What airlines fly to Greenville?

Which airport is the most popular layover for flights between Santa Ana, California and Greenville?

Dallas (DFW) was the most common stop: 67% of momondo users choosing 1-stop flights on this route connected there.

Which layover airport offers the lowest fares from Santa Ana, California to Greenville?

Flights via Chicago (ORD) offer the lowest average round-trip price of $505.

Which layover airport has the shortest travel time from Santa Ana, California to Greenville?

Flights connecting via Dallas (DFW) have the shortest average one-way travel time: 7h 04m.

Which layover airport has the shortest connection time from Santa Ana, California to Greenville?

Chicago (ORD) has the shortest average layover time for this route: 0h 53m.

When to book flights from Santa Ana, California to Greenville

Cheap Santa Ana, California to Greenville (SNA to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana, California to Greenville

Direct flights

How far is Santa Ana J. Wayne/Orange Cnty to Greenville by plane?

When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?

How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?

How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to Greenville Airport?

What documentation or ID do you need to fly to Greenville Airport?

What is the most popular airline from Santa Ana, California to Greenville?

Best airlines flying from Santa Ana, California to Greenville

Compare and see reviews for airlines that fly from Santa Ana, California to Greenville with momondo

Traveling to a place near Greenville?

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to Greenville?

Can I find flights from Santa Ana to Greenville with flexible booking policies on momondo?

How can momondo help me find flights from Santa Ana to Greenville?

I’m not ready to book a flight from Santa Ana to Greenville right now. Can momondo alert me if prices change?

An easier way to manage your Greenville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to the United States

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