Latest deals
Insights
FAQs
Reviews
Price Alerts

Cheap flights from San Francisco to South America from $132

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to South America departing on 3/29. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from San Francisco to South America

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
5:00 am - 9:10 pm
SFO
-
MDE
14h 10m
1 stop
United Airlines Logo
9:45 am - 7:05 pm
MDE
-
SFO
11h 20m
1 stop
$376United Airlines
週三, 4月 15 - 週六, 5月 2
Avianca Logo
11:10 pm - 12:55 pm
SFO
-
MDE
10h 45m
1 stop
Avianca Logo
10:45 pm - 1:00 pm
MDE
-
SFO
16h 15m
2 stops
$377Avianca
週六, 2月 21 - 週一, 3月 9
Avianca Logo
11:10 pm - 12:55 pm
SFO
-
MDE
10h 45m
1 stop
Avianca Logo
10:45 pm - 1:00 pm
MDE
-
SFO
16h 15m
2 stops
$378Avianca
週六, 2月 21 - 週三, 3月 18
United Airlines Logo
12:45 am - 9:10 pm
SFO
-
MDE
18h 25m
1 stop
United Airlines Logo
9:45 am - 11:54 pm
MDE
-
SFO
16h 09m
1 stop
$380United Airlines
週六, 5月 16 - 週四, 5月 28
United Airlines Logo
5:00 am - 9:05 pm
SFO
-
MDE
14h 05m
1 stop
United Airlines Logo
9:45 am - 11:59 pm
MDE
-
SFO
16h 14m
1 stop
$381United Airlines
週日, 3月 8 - 週六, 3月 14
LATAM Airlines Logo
6:05 am - 9:20 pm
SFO
-
LIM
12h 15m
1 stop
LATAM Airlines Logo
12:15 pm - 11:49 pm
LIM
-
SFO
14h 34m
1 stop
$504LATAM Airlines
週五, 2月 20 - 週五, 2月 27
LATAM Airlines Logo
11:47 am - 5:00 am
SFO
-
LIM
14h 13m
1 stop
LATAM Airlines Logo
12:15 am - 3:03 pm
LIM
-
SFO
17h 48m
2 stops
$519LATAM Airlines
週三, 2月 25 - 週二, 3月 3
Copa Airlines Logo
1:12 am - 2:09 pm
SFO
-
UIO
10h 57m
1 stop
Copa Airlines Logo
6:00 am - 11:40 pm
UIO
-
SFO
19h 40m
1 stop
$533Copa Airlines
週二, 5月 5 - 週三, 5月 20
Copa Airlines Logo
12:54 am - 8:50 pm
SFO
-
GRU
14h 56m
1 stop
Copa Airlines Logo
5:25 am - 11:40 pm
GRU
-
SFO
22h 15m
1 stop
$640Copa Airlines
週日, 3月 1 - 週三, 3月 11
American Airlines Logo
10:46 am - 6:55 am
SFO
-
GRU
16h 09m
1 stop
American Airlines Logo
10:25 pm - 2:27 pm
GRU
-
SFO
20h 02m
1 stop
$644American Airlines
週五, 4月 17 - 週五, 4月 24

United Airlines flights from San Francisco to South America

Our best United Airlines deals on San Francisco to South America flight tickets
United Airlines
Apr 5
SFO12:45 amSan Francisco
18h 25m
1 stop
MDE9:10 pmMedellín Jose Maria Cordova Intl
Apr 21
MDE9:45 amMedellín Jose Maria Cordova Intl
16h 14m
1 stop
SFO11:59 pmSan Francisco
$376
United Airlines
May 16
SFO12:45 amSan Francisco
18h 25m
1 stop
MDE9:10 pmMedellín Jose Maria Cordova Intl
May 28
MDE9:45 amMedellín Jose Maria Cordova Intl
16h 09m
1 stop
SFO11:54 pmSan Francisco
$380
United Airlines
Mar 8
SFO5:00 amSan Francisco
14h 05m
1 stop
MDE9:05 pmMedellín Jose Maria Cordova Intl
Mar 14
MDE9:45 amMedellín Jose Maria Cordova Intl
16h 14m
1 stop
SFO11:59 pmSan Francisco
$381

Avianca flights from San Francisco to South America

Our best Avianca deals on San Francisco to South America flight tickets
Avianca
Feb 21
SFO11:10 pmSan Francisco
10h 45m
1 stop
MDE12:55 pmMedellín Jose Maria Cordova Intl
Mar 9
MDE10:45 pmMedellín Jose Maria Cordova Intl
16h 15m
2 stops
SFO1:00 pmSan Francisco
$377
Avianca
Feb 21
SFO11:10 pmSan Francisco
10h 45m
1 stop
MDE12:55 pmMedellín Jose Maria Cordova Intl
Mar 18
MDE10:45 pmMedellín Jose Maria Cordova Intl
16h 15m
2 stops
SFO1:00 pmSan Francisco
$378
Avianca
May 19
SFO11:55 pmSan Francisco
11h 15m
1 stop
MDE1:10 pmMedellín Jose Maria Cordova Intl
May 27
MDE2:10 pmMedellín Jose Maria Cordova Intl
10h 25m
1 stop
SFO10:35 pmSan Francisco
$394

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated 2月 5, 2026.
Use the filters below to find and compare flights from San Francisco to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

週三 4/15

5:00 am-9:10 pm

1 stop14h 10m

Medellín Jose Maria Cordova Intl

週六 5/2

9:45 am-7:05 pm

1 stop11h 20m

$376

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

週六 2/21

11:10 pm-12:55 pm

1 stop10h 45m

Medellín Jose Maria Cordova Intl

週一 3/9

10:45 pm-1:00 pm

2 stops16h 15m

$377

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

週六 2/21

11:10 pm-12:55 pm

1 stop10h 45m

Medellín Jose Maria Cordova Intl

週三 3/18

10:45 pm-1:00 pm

2 stops16h 15m

$378

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

週六 5/16

12:45 am-9:10 pm

1 stop18h 25m

Medellín Jose Maria Cordova Intl

週四 5/28

9:45 am-11:54 pm

1 stop16h 09m

$380

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

週日 3/8

5:00 am-9:05 pm

1 stop14h 05m

Medellín Jose Maria Cordova Intl

週六 3/14

9:45 am-11:59 pm

1 stop16h 14m

$381

San FranciscoLima

SFO - LIM

SFOLIM

San Francisco

週五 2/20

6:05 am-9:20 pm

1 stop12h 15m

Lima J Chavez Intl

週五 2/27

12:15 pm-11:49 pm

1 stop14h 34m

$504

San FranciscoLima

SFO - LIM

SFOLIM

San Francisco

週三 2/25

11:47 am-5:00 am

1 stop14h 13m

Lima J Chavez Intl

週二 3/3

12:15 am-3:03 pm

2 stops17h 48m

$519

San FranciscoQuito

SFO - UIO

SFOUIO

San Francisco

週二 5/5

1:12 am-2:09 pm

1 stop10h 57m

Quito Mariscal Sucr

週三 5/20

6:00 am-11:40 pm

1 stop19h 40m

$533

San FranciscoSao Paulo

SFO - GRU

SFOGRU

San Francisco

週日 3/1

12:54 am-8:50 pm

1 stop14h 56m

Sao Paulo Guarulhos Intl

週三 3/11

5:25 am-11:40 pm

1 stop22h 15m

$640

San FranciscoSao Paulo

SFO - GRU

SFOGRU

San Francisco

週五 4/17

10:46 am-6:55 am

1 stop16h 09m

Sao Paulo Guarulhos Intl

週五 4/24

10:25 pm-2:27 pm

1 stop20h 02m

$644

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

How to get the cheapest flight ticket from San Francisco to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

In general, September is the cheapest month to fly from San Francisco to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $628. If you aren’t able to travel during the month of September, then book flights to South America from San Francisco during February instead. Flights to South America in February, while not as cheap as those in September, still average around $632.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $701 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from San Francisco for as low as $657 on momondo.

Can stopping save me money on San Francisco to South America flights?

You could potentially save up to 11% on your flight if you consider stops on a San Francisco to South America flight.

Cheap San Francisco to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to South America

Fastest flight time

10h 20m

Direct flights

None
The fastest flight from San Francisco to South America takes 10h 20m
There are no direct flights from San Francisco to South America. There are no popular flight routes from San Francisco to South America.
Search flight deals

  • When did momondo last update prices for flights from San Francisco Airport to South America?

    Prices for flights from San Francisco Airport to South America are updated daily.

  • How many operators does momondo search for flights from San Francisco Airport to South America?

  • How old do you have to be to fly from San Francisco Airport to South America?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Francisco Airport to South America.

  • What documentation or ID do you need to fly to South America?

    The necessary travel and health documents for your South America trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from San Francisco to South America

Compare and see reviews for airlines that fly from San Francisco to South America with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $214Free CancellationRating
7.4
9,242 reviews
Search United Airlines flights
JetBluePriceFrom $224Free CancellationRating
7.2
2,895 reviews
Search JetBlue flights
LATAM AirlinesPriceFrom $258Free CancellationRating
7.5
1,917 reviews
Search LATAM Airlines flights
Copa AirlinesPriceFrom $293Free CancellationRating
7.5
1,556 reviews
Search Copa Airlines flights
DeltaPriceFrom $304Free CancellationRating
7.9
8,158 reviews
Search Delta flights
AviancaPriceFrom $307Free CancellationRating
6.5
2,498 reviews
Search Avianca flights
AeromexicoPriceFrom $453Free CancellationRating
7.4
1,578 reviews
Search Aeromexico flights
American AirlinesPriceFrom $463Free CancellationRating
7.2
11,243 reviews
Search American Airlines flights
Air CanadaPriceFrom $531Free CancellationRating
7.1
10,696 reviews
Search Air Canada flights
GOLPriceFrom $668Free CancellationRating
7.3
1,167 reviews
Search GOL flights

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to South America?

It is quick and easy to find San Francisco to South America flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South America that suits you.

Can I find flights from San Francisco to South America with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for San Francisco to South America flights to just show those with flexible booking policies.

How can momondo help me find flights from San Francisco to South America?

momondo provides multiple filters to help you find the best flight to South America from San Francisco. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from San Francisco to South America right now. Can momondo alert me if prices change?

If you are not ready to book a flight from San Francisco to South America now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South America and let you know when they change.

An easier way to manage your South America trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
週六 3/7
週六 3/14
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to South America

Popular cities in South America

Popular flights according to clicks in the last 7 days on momondo
Flights to Limafrom $187
Flights to Buenos Airesfrom $503
Flights to Sao Paulofrom $369
Flights to Bogotáfrom $159
Flights to Rio de Janeirofrom $488
Flights to Medellínfrom $165
Flights to Santiagofrom $376
Flights to Cartagenafrom $164
Flights to Quitofrom $295
Flights to Guayaquilfrom $165
Flights to Cuscofrom $336
Flights to Califrom $179