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Cheap flights from San Francisco to South America from $165

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to South America departing on 1/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from San Francisco to South America

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
11:59 pm - 10:05 pmSFO-MDE
19h 06m1 stop
United Airlines Logo
1:15 am - 12:09 pmMDE-SFO
13h 54m1 stop
$451United Airlines
Find Deal
Wed, Dec 3 - Mon, Dec 15
United Airlines Logo
12:43 am - 10:05 pmSFO-MDE
18h 22m1 stop
United Airlines Logo
10:45 am - 9:05 pmMDE-SFO
13h 20m1 stop
$452United Airlines
Find Deal
Fri, Dec 5 - Wed, Dec 10
LATAM Airlines Logo
6:00 am - 7:30 pmSFO-BOG
10h 30m1 stop
LATAM Airlines Logo
7:00 am - 7:56 pmBOG-SFO
15h 56m2 stops
$453LATAM Airlines
Find Deal
Wed, Feb 4 - Wed, Feb 25
Avianca Logo
1:35 am - 4:00 pmSFO-BOG
11h 25m1 stop
Avianca Logo
9:10 am - 9:50 pmBOG-SFO
15h 40m1 stop
$454Avianca
Find Deal
Sat, Jan 17 - Sat, Jan 24
LATAM Airlines Logo
9:35 pm - 2:25 pmSFO-BOG
13h 50m1 stop
LATAM Airlines Logo
10:55 am - 12:20 amBOG-SFO
16h 25m2 stops
$460LATAM Airlines
Find Deal
Thu, Nov 27 - Thu, Dec 4
Avianca Logo
1:35 am - 4:00 pmSFO-BOG
11h 25m1 stop
Avianca Logo
9:10 am - 9:50 pmBOG-SFO
15h 40m1 stop
$461Avianca
Find Deal
Sat, Feb 14 - Sat, Feb 21
American Airlines Logo
8:00 am - 9:00 amSFO-SCL
20h 00m1 stop
American Airlines Logo
10:30 pm - 12:40 pmSCL-SFO
19h 10m2 stops
$499American Airlines
Find Deal
Thu, Jan 22 - Mon, Feb 2
Copa Airlines Logo
1:42 am - 11:32 pmSFO-SCL
18h 50m1 stop
Copa Airlines Logo
2:34 am - 6:25 pmSCL-SFO
18h 51m1 stop
$502Copa Airlines
Find Deal
Sat, Apr 11 - Sat, Apr 18
American Airlines Logo
12:17 am - 8:15 amSFO-SCL
26h 58m1 stop
American Airlines Logo
10:30 pm - 12:40 pmSCL-SFO
19h 10m2 stops
$507American Airlines
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Sun, Jan 11 - Mon, Feb 2
Copa Airlines Logo
1:42 am - 3:14 amSFO-SCL
22h 32m1 stop
Copa Airlines Logo
12:16 am - 11:40 pmSCL-SFO
26h 24m1 stop
$522Copa Airlines
Find Deal
Wed, Apr 15 - Wed, Apr 29

LATAM Airlines flights from San Francisco to South America

Our best LATAM Airlines deals on San Francisco to South America flight tickets
LATAM Airlines
Feb 4
SFO6:00 amSan Francisco
10h 30m
1 stop
BOG7:30 pmBogotá El Dorado
Feb 25
BOG7:00 amBogotá El Dorado
15h 56m
2 stops
SFO7:56 pmSan Francisco
$453
Find similar
LATAM Airlines
Nov 27
SFO9:35 pmSan Francisco
13h 50m
1 stop
BOG2:25 pmBogotá El Dorado
Dec 4
BOG9:00 amBogotá El Dorado
12h 16m
1 stop
SFO6:16 pmSan Francisco
$459
Find similar
LATAM Airlines
Nov 27
SFO9:35 pmSan Francisco
13h 50m
1 stop
BOG2:25 pmBogotá El Dorado
Dec 4
BOG10:55 amBogotá El Dorado
16h 25m
2 stops
SFO12:20 amSan Francisco
$460
Find similar

Avianca flights from San Francisco to South America

Our best Avianca deals on San Francisco to South America flight tickets
Avianca
Jan 17
SFO1:35 amSan Francisco
11h 25m
1 stop
BOG4:00 pmBogotá El Dorado
Jan 24
BOG9:10 amBogotá El Dorado
15h 40m
1 stop
SFO9:50 pmSan Francisco
$454
Find similar
Avianca
Feb 14
SFO1:35 amSan Francisco
11h 25m
1 stop
BOG4:00 pmBogotá El Dorado
Feb 21
BOG9:10 amBogotá El Dorado
15h 40m
1 stop
SFO9:50 pmSan Francisco
$461
Find similar
Avianca
Jan 24
SFO11:10 pmSan Francisco
10h 45m
1 stop
MDE12:55 pmMedellín Jose Maria Cordova Intl
Jan 28
MDE2:10 pmMedellín Jose Maria Cordova Intl
10h 40m
1 stop
SFO9:50 pmSan Francisco
$468
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 17, 2025.
Use the filters below to find and compare flights from San Francisco to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

Wed 12/3

11:59 pm-10:05 pm

1 stop19h 06m

Medellín Jose Maria Cordova Intl

Mon 12/15

1:15 am-12:09 pm

1 stop13h 54m

$451

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

Fri 12/5

12:43 am-10:05 pm

1 stop18h 22m

Medellín Jose Maria Cordova Intl

Wed 12/10

10:45 am-9:05 pm

1 stop13h 20m

$452

San FranciscoBogotá

SFO - BOG

SFOBOG

San Francisco

Wed 2/4

6:00 am-7:30 pm

1 stop10h 30m

Bogotá El Dorado

Wed 2/25

7:00 am-7:56 pm

2 stops15h 56m

$453

San FranciscoBogotá

SFO - BOG

SFOBOG

San Francisco

Sat 1/17

1:35 am-4:00 pm

1 stop11h 25m

Bogotá El Dorado

Sat 1/24

9:10 am-9:50 pm

1 stop15h 40m

$454

San FranciscoBogotá

SFO - BOG

SFOBOG

San Francisco

Thu 11/27

9:35 pm-2:25 pm

1 stop13h 50m

Bogotá El Dorado

Thu 12/4

10:55 am-12:20 am

2 stops16h 25m

$460

San FranciscoBogotá

SFO - BOG

SFOBOG

San Francisco

Sat 2/14

1:35 am-4:00 pm

1 stop11h 25m

Bogotá El Dorado

Sat 2/21

9:10 am-9:50 pm

1 stop15h 40m

$461

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Thu 1/22

8:00 am-9:00 am

1 stop20h 00m

Santiago Arturo Merino Benitez

Mon 2/2

10:30 pm-12:40 pm

2 stops19h 10m

$499

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sat 4/11

1:42 am-11:32 pm

1 stop18h 50m

Santiago Arturo Merino Benitez

Sat 4/18

2:34 am-6:25 pm

1 stop18h 51m

$502

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sun 1/11

12:17 am-8:15 am

1 stop26h 58m

Santiago Arturo Merino Benitez

Mon 2/2

10:30 pm-12:40 pm

2 stops19h 10m

$507

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Wed 4/15

1:42 am-3:14 am

1 stop22h 32m

Santiago Arturo Merino Benitez

Wed 4/29

12:16 am-11:40 pm

1 stop26h 24m

$522

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from San Francisco to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

In general, September is the cheapest month to fly from San Francisco to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $616. If you aren’t able to travel during the month of September, then book flights to South America from San Francisco during October instead. Flights to South America in October, while not as cheap as those in September, still average around $642.

What is the cheapest day to depart on your flight to South America?

The cheapest day to depart from San Francisco to South America is on a Tuesday when prices can be found for as low as $688. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from San Francisco to South America for around $773.

What is the cheapest time of day to depart on your flight to South America?

Our data shows that the cheapest San Francisco to South America flights are usually those with departure times in the morning. Our users have found flights to South America in the morning for as low as $726. If you have a flexible travel schedule, then try to avoid flying at noon when prices are $738 on average. Flights to South America from San Francisco at noon are generally more expensive because this time of day is more convenient for travelers’ schedules.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $717 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from San Francisco for as low as $634 on momondo.

Can stopping save me money on San Francisco to South America flights?

You could potentially save up to 5% on your flight if you consider stops on a San Francisco to South America flight.

Cheap San Francisco to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to South America

Direct flights

None
There are no direct flights from San Francisco to South America. There are no popular flight routes from San Francisco to South America.
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  • When did momondo last update prices for flights from San Francisco Airport to South America?

    Prices for flights from San Francisco Airport to South America are updated daily.

  • How many operators does momondo search for flights from San Francisco Airport to South America?

  • How old do you have to be to fly from San Francisco Airport to South America?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Francisco Airport to South America.

  • What documentation or ID do you need to fly to South America?

    The necessary travel and health documents for your South America trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from San Francisco to South America

Compare and see reviews for airlines that fly from San Francisco to South America with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $366Free CancellationRating
7.9
8,007 reviews
Search Delta flights
AviancaPriceFrom $381Free CancellationRating
6.6
2,475 reviews
Search Avianca flights
United AirlinesPriceFrom $392Free CancellationRating
7.4
9,015 reviews
Search United Airlines flights
LATAM AirlinesPriceFrom $399Free CancellationRating
7.5
1,876 reviews
Search LATAM Airlines flights
Copa AirlinesPriceFrom $403Free CancellationRating
7.6
1,566 reviews
Search Copa Airlines flights
JetBluePriceFrom $409Free CancellationRating
7.2
2,905 reviews
Search JetBlue flights
American AirlinesPriceFrom $463Free CancellationRating
7.2
11,048 reviews
Search American Airlines flights
Air CanadaPriceFrom $531Free CancellationRating
7.1
10,459 reviews
Search Air Canada flights
AeromexicoPriceFrom $652Free CancellationRating
7.4
1,660 reviews
Search Aeromexico flights
GOLPriceFrom $765Free CancellationRating
7.3
1,129 reviews
Search GOL flights

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to South America?

It is quick and easy to find San Francisco to South America flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South America that suits you.

Can I find flights from San Francisco to South America with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for San Francisco to South America flights to just show those with flexible booking policies.

How can momondo help me find flights from San Francisco to South America?

momondo provides multiple filters to help you find the best flight to South America from San Francisco. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from San Francisco to South America right now. Can momondo alert me if prices change?

If you are not ready to book a flight from San Francisco to South America now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South America and let you know when they change.

An easier way to manage your South America trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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Find better results for your trip to South America

Popular cities in South America

Popular flights according to clicks in the last 7 days on momondo
Flights to Limafrom $300
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Flights to Bogotáfrom $182
Flights to Sao Paulofrom $300
Flights to Rio de Janeirofrom $451
Flights to Medellínfrom $166
Flights to Santiagofrom $356
Flights to Cartagenafrom $167
Flights to Quitofrom $231
Flights to Cuscofrom $426
Flights to Guayaquilfrom $208
Flights to Califrom $187