What is the cheapest airline that flies from San Francisco to South America?

Avianca, American Airlines, and United Airlines are the most popular carriers operating from San Francisco to South America

What airlines fly to South America?

Copa Airlines, Avianca and United Airlines are the top three most popular airlines that fly to South America from San Francisco according to our data. Copa Airlines is the first choice among our users, with 31% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 10 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from San Francisco Airport to South America?

Prices for flights from San Francisco Airport to South America are updated daily.

How many operators does momondo search for flights from San Francisco Airport to South America?

There are 10 operators available for flights from San Francisco Airport to South America as of February 2026.

How old do you have to be to fly from San Francisco Airport to South America?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Francisco Airport to South America.

What documentation or ID do you need to fly to South America?

The necessary travel and health documents for your South America trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$173 Cheap Flights from San Francisco to South America in 2026

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Find the cheapest flights from San Francisco to South America

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

2:15 pm - 4:50 pm

SFO

MDE

24h 35m

2 stops

6:20 am - 11:55 pm

MDE

SFO

19h 35m

2 stops

$378Avianca

Thu, May 7 - Sat, May 16

2:30 am - 8:45 pm

SFO

MDE

16h 15m

2 stops

2:10 pm - 11:55 pm

MDE

SFO

11h 45m

1 stop

$380Avianca

Tue, May 12 - Tue, May 19

12:45 am - 9:10 pm

SFO

MDE

18h 25m

1 stop

9:45 am - 7:16 am

MDE

SFO

23h 31m

1 stop

$391United Airlines

Wed, Apr 8 - Mon, Apr 20

6:55 pm - 7:20 pm

SFO

BOG

22h 25m

1 stop

8:30 am - 7:16 am

BOG

SFO

24h 46m

1 stop

$392United Airlines

Sat, Apr 11 - Sun, Apr 19

1:54 am - 1:20 am

SFO

LIM

21h 26m

1 stop

10:30 am - 11:40 pm

LIM

SFO

15h 10m

1 stop

$511Copa Airlines

Mon, Mar 16 - Tue, Mar 24

1:20 pm - 4:10 am

SFO

LIM

12h 50m

1 stop

6:30 am - 10:20 pm

LIM

SFO

17h 50m

2 stops

$515American Airlines

Mon, Mar 16 - Tue, Mar 31

10:55 pm - 11:25 pm

SFO

LIM

21h 30m

1 stop

6:05 am - 9:16 pm

LIM

SFO

17h 11m

1 stop

$523American Airlines

Mon, Mar 2 - Mon, Mar 9

8:00 am - 5:00 am

SFO

LIM

19h 00m

1 stop

12:00 pm - 12:46 am

LIM

SFO

14h 46m

1 stop

$525LATAM Airlines

Tue, May 5 - Mon, May 18

6:00 am - 5:40 am

SFO

GRU

18h 40m

1 stop

11:45 pm - 1:06 pm

GRU

SFO

17h 21m

1 stop

$626LATAM Airlines

Mon, Mar 2 - Wed, Mar 11

12:54 am - 6:30 am

SFO

GRU

24h 36m

1 stop

5:25 am - 11:40 pm

GRU

SFO

22h 15m

1 stop

$640Copa Airlines

Sun, Mar 1 - Wed, Mar 11

GOL flights from San Francisco to South America

Our best GOL deals on San Francisco to South America flight tickets

GOL

Mar 1

SFO10:55 pmSan Francisco

12h 20m

1 stop

BOG2:15 pmBogotá El Dorado

Mar 10

BOG7:05 amBogotá El Dorado

16h 11m

1 stop

SFO9:16 pmSan Francisco

$436

GOL

Mar 6

SFO11:35 pmSan Francisco

20h 55m

1 stop

BOG11:30 pmBogotá El Dorado

Mar 9

BOG2:15 pmBogotá El Dorado

20h 56m

2 stops

SFO9:11 amSan Francisco

$448

GOL

Mar 23

SFO7:25 amSan Francisco

13h 14m

1 stop

MDE10:39 pmMedellín Jose Maria Cordova Intl

Mar 30

MDE6:00 amMedellín Jose Maria Cordova Intl

30h 50m

1 stop

SFO10:50 amSan Francisco

$449

United Airlines flights from San Francisco to South America

Our best United Airlines deals on San Francisco to South America flight tickets

United Airlines

Feb 21

SFO5:00 amSan Francisco

14h 35m

1 stop

BOG10:35 pmBogotá El Dorado

Mar 12

BOG1:30 amBogotá El Dorado

24h 29m

1 stop

SFO11:59 pmSan Francisco

$388

United Airlines

Feb 21

SFO11:59 pmSan Francisco

26h 11m

1 stop

BOG5:10 amBogotá El Dorado

Mar 12

BOG1:30 amBogotá El Dorado

24h 29m

1 stop

SFO11:59 pmSan Francisco

$389

United Airlines

Apr 8

SFO12:45 amSan Francisco

18h 25m

1 stop

MDE9:10 pmMedellín Jose Maria Cordova Intl

Apr 20

MDE9:45 amMedellín Jose Maria Cordova Intl

23h 31m

1 stop

SFO7:16 amSan Francisco

$391

momondo Fare Finder

Use the filters below to find and compare flights from San Francisco to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

Thu 5/7

2:15 pm-4:50 pm

2 stops24h 35m

Medellín Jose Maria Cordova Intl

Sat 5/16

6:20 am-11:55 pm

2 stops19h 35m

$378

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

Tue 5/12

2:30 am-8:45 pm

2 stops16h 15m

Medellín Jose Maria Cordova Intl

Tue 5/19

2:10 pm-11:55 pm

1 stop11h 45m

$380

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

Wed 4/8

12:45 am-9:10 pm

1 stop18h 25m

Medellín Jose Maria Cordova Intl

Mon 4/20

9:45 am-7:16 am

1 stop23h 31m

$391

San FranciscoBogotá

SFO - BOG

SFOBOG

San Francisco

Sat 4/11

6:55 pm-7:20 pm

1 stop22h 25m

Bogotá El Dorado

Sun 4/19

8:30 am-7:16 am

1 stop24h 46m

$392

San FranciscoLima

SFO - LIM

SFOLIM

San Francisco

Mon 3/16

1:54 am-1:20 am

1 stop21h 26m

Lima J Chavez Intl

Tue 3/24

10:30 am-11:40 pm

1 stop15h 10m

$511

San FranciscoLima

SFO - LIM

SFOLIM

San Francisco

Mon 3/16

1:20 pm-4:10 am

1 stop12h 50m

Lima J Chavez Intl

Tue 3/31

6:30 am-10:20 pm

2 stops17h 50m

$515

San FranciscoLima

SFO - LIM

SFOLIM

San Francisco

Mon 3/2

10:55 pm-11:25 pm

1 stop21h 30m

Lima J Chavez Intl

Mon 3/9

6:05 am-9:16 pm

1 stop17h 11m

$523

San FranciscoLima

SFO - LIM

SFOLIM

San Francisco

Tue 5/5

8:00 am-5:00 am

1 stop19h 00m

Lima J Chavez Intl

Mon 5/18

12:00 pm-12:46 am

1 stop14h 46m

$525

San FranciscoSao Paulo

SFO - GRU

SFOGRU

San Francisco

Mon 3/2

6:00 am-5:40 am

1 stop18h 40m

Sao Paulo Guarulhos Intl

Wed 3/11

11:45 pm-1:06 pm

1 stop17h 21m

$626

San FranciscoSao Paulo

SFO - GRU

SFOGRU

San Francisco

Sun 3/1

12:54 am-6:30 am

1 stop24h 36m

Sao Paulo Guarulhos Intl

Wed 3/11

5:25 am-11:40 pm

1 stop22h 15m

$640

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from San Francisco to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South America?

In general, February is the cheapest month to fly from San Francisco to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $623. If you aren’t able to travel during the month of February, then book flights to South America from San Francisco during September instead. Flights to South America in September, while not as cheap as those in February, still average around $632.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $698 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from San Francisco for as low as $652 on momondo.

Can stopping save me money on San Francisco to South America flights?

You could potentially save up to 28% on your flight if you consider stops on a San Francisco to South America flight.

Cheap San Francisco to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to South America

Fastest flight time	10h 00m
Direct flights	None

The fastest flight from San Francisco to South America takes 10h 00m

There are no direct flights from San Francisco to South America. There are no popular flight routes from San Francisco to South America.

Search flight deals

When did momondo last update prices for flights from San Francisco Airport to South America?
Prices for flights from San Francisco Airport to South America are updated daily.
How many operators does momondo search for flights from San Francisco Airport to South America?
There are 10 operators available for flights from San Francisco Airport to South America as of February 2026.
How old do you have to be to fly from San Francisco Airport to South America?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Francisco Airport to South America.
What documentation or ID do you need to fly to South America?
The necessary travel and health documents for your South America trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from San Francisco to South America

Compare and see reviews for airlines that fly from San Francisco to South America with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $214	Free Cancellation	Rating 7.4 9,299 reviews	Search United Airlines flights
JetBlue	PriceFrom $224	Free Cancellation	Rating 7.2 2,899 reviews	Search JetBlue flights
LATAM Airlines	PriceFrom $258	Free Cancellation	Rating 7.5 1,919 reviews	Search LATAM Airlines flights
Copa Airlines	PriceFrom $291	Free Cancellation	Rating 7.5 1,555 reviews	Search Copa Airlines flights
Avianca	PriceFrom $308	Free Cancellation	Rating 6.6 2,496 reviews	Search Avianca flights
Delta	PriceFrom $332	Free Cancellation	Rating 7.9 8,204 reviews	Search Delta flights
Aeromexico	PriceFrom $453	Free Cancellation	Rating 7.4 1,577 reviews	Search Aeromexico flights
American Airlines	PriceFrom $463	Free Cancellation	Rating 7.2 11,291 reviews	Search American Airlines flights
Air Canada	PriceFrom $531	Free Cancellation	Rating 7.1 10,722 reviews	Search Air Canada flights
GOL	PriceFrom $668	Free Cancellation	Rating 7.3 1,171 reviews	Search GOL flights

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to South America?

It is quick and easy to find San Francisco to South America flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South America that suits you.

Can I find flights from San Francisco to South America with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for San Francisco to South America flights to just show those with flexible booking policies.

How can momondo help me find flights from San Francisco to South America?

momondo provides multiple filters to help you find the best flight to South America from San Francisco. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from San Francisco to South America right now. Can momondo alert me if prices change?

If you are not ready to book a flight from San Francisco to South America now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South America and let you know when they change.