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Cheap flights from San Francisco to South America from $178

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to South America departing on 3/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Francisco to South America

Cheap round-trip flights

Enter your travel dates to find the best prices.
Avianca Logo
1:20 pm - 6:05 am
SFO
-
MDE
13h 45m
2 stops
Avianca Logo
2:10 pm - 9:50 pm
MDE
-
SFO
10h 40m
1 stop
$378Avianca
Wed, Feb 25 - Wed, Mar 4
United Airlines Logo
4:10 pm - 10:05 pm
SFO
-
MDE
26h 55m
1 stop
United Airlines Logo
10:45 am - 7:04 pm
MDE
-
SFO
11h 19m
1 stop
$379United Airlines
Mon, Feb 9 - Sat, Feb 14
Avianca Logo
1:20 pm - 6:05 am
SFO
-
MDE
13h 45m
2 stops
Avianca Logo
10:40 am - 9:50 pm
MDE
-
SFO
14h 10m
2 stops
$384Avianca
Wed, Feb 25 - Wed, Mar 4
United Airlines Logo
7:10 pm - 10:05 pm
SFO
-
MDE
23h 55m
1 stop
United Airlines Logo
10:45 am - 7:31 am
MDE
-
SFO
23h 46m
1 stop
$388United Airlines
Mon, Feb 9 - Wed, Feb 18
Avianca Logo
11:10 pm - 12:55 pm
SFO
-
MDE
10h 45m
1 stop
Avianca Logo
10:15 pm - 12:00 pm
MDE
-
SFO
16h 45m
2 stops
$397Avianca
Mon, Feb 23 - Mon, Mar 2
Copa Airlines Logo
12:42 am - 3:40 pm
SFO
-
LIM
11h 58m
1 stop
Copa Airlines Logo
3:30 am - 11:16 pm
LIM
-
SFO
22h 46m
1 stop
$511Copa Airlines
Mon, Feb 23 - Mon, Mar 2
Copa Airlines Logo
12:42 am - 2:09 pm
SFO
-
UIO
10h 27m
1 stop
Copa Airlines Logo
6:03 am - 11:16 pm
UIO
-
SFO
20h 13m
1 stop
$533Copa Airlines
Mon, Feb 23 - Wed, Mar 4
LATAM Airlines Logo
11:05 am - 5:35 am
SFO
-
SCL
15h 30m
1 stop
LATAM Airlines Logo
11:25 pm - 11:59 am
SCL
-
SFO
15h 34m
1 stop
$615LATAM Airlines
Wed, Jun 3 - Wed, Jul 15
LATAM Airlines Logo
11:45 pm - 5:35 am
SFO
-
SCL
26h 50m
2 stops
LATAM Airlines Logo
11:00 pm - 9:21 pm
SCL
-
SFO
25h 21m
2 stops
$620LATAM Airlines
Tue, Jun 2 - Mon, Jul 13
American Airlines Logo
9:25 am - 8:10 am
SFO
-
GRU
17h 45m
2 stops
American Airlines Logo
11:00 pm - 3:05 pm
GRU
-
SFO
20h 05m
1 stop
$630American Airlines
Mon, Mar 2 - Tue, Mar 17

United Airlines flights from San Francisco to South America

Our best United Airlines deals on San Francisco to South America flight tickets
United Airlines
Feb 9
SFO7:10 pmSan Francisco
23h 55m
1 stop
MDE10:05 pmMedellín Jose Maria Cordova Intl
Feb 19
MDE10:45 amMedellín Jose Maria Cordova Intl
16h 14m
1 stop
SFO11:59 pmSan Francisco
$379
United Airlines
Feb 9
SFO7:10 pmSan Francisco
23h 55m
1 stop
MDE10:05 pmMedellín Jose Maria Cordova Intl
Feb 18
MDE10:45 amMedellín Jose Maria Cordova Intl
23h 46m
1 stop
SFO7:31 amSan Francisco
$388
United Airlines
Jan 31
SFO11:59 pmSan Francisco
19h 36m
1 stop
BOG10:35 pmBogotá El Dorado
Feb 8
BOG8:15 amBogotá El Dorado
15h 50m
1 stop
SFO9:05 pmSan Francisco
$430

Delta flights from San Francisco to South America

Our best Delta deals on San Francisco to South America flight tickets
Delta
Feb 1
SFO11:05 pmSan Francisco
17h 25m
1 stop
BOG7:30 pmBogotá El Dorado
Feb 12
BOG6:35 pmBogotá El Dorado
19h 01m
2 stops
SFO10:36 amSan Francisco
$465
Delta
Feb 10
SFO6:49 pmSan Francisco
22h 31m
2 stops
BOG8:20 pmBogotá El Dorado
Mar 2
BOG6:15 amBogotá El Dorado
20h 34m
2 stops
SFO11:49 pmSan Francisco
$470
Delta
Jan 29
SFO11:40 amSan Francisco
15h 20m
2 stops
LIM6:00 amLima J Chavez Intl
Feb 15
LIM11:40 pmLima J Chavez Intl
13h 56m
1 stop
SFO10:36 amSan Francisco
$537

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 27, 2026.
Use the filters below to find and compare flights from San Francisco to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

Wed 2/25

1:20 pm-6:05 am

2 stops13h 45m

Medellín Jose Maria Cordova Intl

Wed 3/4

2:10 pm-9:50 pm

1 stop10h 40m

$378

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

Mon 2/9

4:10 pm-10:05 pm

1 stop26h 55m

Medellín Jose Maria Cordova Intl

Sat 2/14

10:45 am-7:04 pm

1 stop11h 19m

$379

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

Wed 2/25

1:20 pm-6:05 am

2 stops13h 45m

Medellín Jose Maria Cordova Intl

Wed 3/4

10:40 am-9:50 pm

2 stops14h 10m

$384

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

Mon 2/9

7:10 pm-10:05 pm

1 stop23h 55m

Medellín Jose Maria Cordova Intl

Wed 2/18

10:45 am-7:31 am

1 stop23h 46m

$388

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

Mon 2/23

11:10 pm-12:55 pm

1 stop10h 45m

Medellín Jose Maria Cordova Intl

Mon 3/2

10:15 pm-12:00 pm

2 stops16h 45m

$397

San FranciscoLima

SFO - LIM

SFOLIM

San Francisco

Mon 2/23

12:42 am-3:40 pm

1 stop11h 58m

Lima J Chavez Intl

Mon 3/2

3:30 am-11:16 pm

1 stop22h 46m

$511

San FranciscoQuito

SFO - UIO

SFOUIO

San Francisco

Mon 2/23

12:42 am-2:09 pm

1 stop10h 27m

Quito Mariscal Sucr

Wed 3/4

6:03 am-11:16 pm

1 stop20h 13m

$533

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Wed 6/3

11:05 am-5:35 am

1 stop15h 30m

Santiago Arturo Merino Benitez

Wed 7/15

11:25 pm-11:59 am

1 stop15h 34m

$615

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 6/2

11:45 pm-5:35 am

2 stops26h 50m

Santiago Arturo Merino Benitez

Mon 7/13

11:00 pm-9:21 pm

2 stops25h 21m

$620

San FranciscoSao Paulo

SFO - GRU

SFOGRU

San Francisco

Mon 3/2

9:25 am-8:10 am

2 stops17h 45m

Sao Paulo Guarulhos Intl

Tue 3/17

11:00 pm-3:05 pm

1 stop20h 05m

$630

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from San Francisco to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

In general, September is the cheapest month to fly from San Francisco to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $628. If you aren’t able to travel during the month of September, then book flights to South America from San Francisco during February instead. Flights to South America in February, while not as cheap as those in September, still average around $636.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $701 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from San Francisco for as low as $656 on momondo.

Can stopping save me money on San Francisco to South America flights?

You could potentially save up to 11% on your flight if you consider stops on a San Francisco to South America flight.

Cheap San Francisco to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to South America

Fastest flight time

9h 30m

Direct flights

None
The fastest flight from San Francisco to South America takes 9h 30m
There are no direct flights from San Francisco to South America. There are no popular flight routes from San Francisco to South America.
Search flight deals

  • When did momondo last update prices for flights from San Francisco Airport to South America?

    Prices for flights from San Francisco Airport to South America are updated daily.

  • How many operators does momondo search for flights from San Francisco Airport to South America?

  • How old do you have to be to fly from San Francisco Airport to South America?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Francisco Airport to South America.

  • What documentation or ID do you need to fly to South America?

    The necessary travel and health documents for your South America trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from San Francisco to South America

Compare and see reviews for airlines that fly from San Francisco to South America with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $214Free CancellationRating
7.4
9,209 reviews
Search United Airlines flights
JetBluePriceFrom $224Free CancellationRating
7.2
2,890 reviews
Search JetBlue flights
LATAM AirlinesPriceFrom $258Free CancellationRating
7.5
1,915 reviews
Search LATAM Airlines flights
Copa AirlinesPriceFrom $293Free CancellationRating
7.5
1,560 reviews
Search Copa Airlines flights
DeltaPriceFrom $304Free CancellationRating
7.9
8,123 reviews
Search Delta flights
AviancaPriceFrom $309Free CancellationRating
6.6
2,486 reviews
Search Avianca flights
AeromexicoPriceFrom $453Free CancellationRating
7.4
1,589 reviews
Search Aeromexico flights
American AirlinesPriceFrom $463Free CancellationRating
7.2
11,201 reviews
Search American Airlines flights
Air CanadaPriceFrom $531Free CancellationRating
7.1
10,666 reviews
Search Air Canada flights
GOLPriceFrom $668Free CancellationRating
7.3
1,159 reviews
Search GOL flights

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to South America?

It is quick and easy to find San Francisco to South America flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South America that suits you.

Can I find flights from San Francisco to South America with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for San Francisco to South America flights to just show those with flexible booking policies.

How can momondo help me find flights from San Francisco to South America?

momondo provides multiple filters to help you find the best flight to South America from San Francisco. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from San Francisco to South America right now. Can momondo alert me if prices change?

If you are not ready to book a flight from San Francisco to South America now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South America and let you know when they change.

An easier way to manage your South America trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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Find better results for your trip to South America

Popular cities in South America

Popular flights according to clicks in the last 7 days on momondo
Flights to Limafrom $239
Flights to Buenos Airesfrom $475
Flights to Sao Paulofrom $352
Flights to Bogotáfrom $162
Flights to Rio de Janeirofrom $486
Flights to Medellínfrom $168
Flights to Santiagofrom $357
Flights to Cartagenafrom $139
Flights to Quitofrom $278
Flights to Cuscofrom $457
Flights to Guayaquilfrom $54
Flights to Califrom $168