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Cheap flights from San Francisco to South America from $187

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to South America departing on 3/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from San Francisco to South America

Cheap round-trip flights

Enter your travel dates to find the best prices.
Avianca Logo
11:10 pm - 12:55 pm
SFO
-
MDE
10h 45m
1 stop
Avianca Logo
2:10 pm - 11:20 pm
MDE
-
SFO
12h 10m
1 stop
$390Avianca
Sun, Jan 25 - Tue, Feb 24
Multiple Airlines Logo
12:45 am - 9:10 pm
SFO
-
MDE
18h 25m
1 stop
Multiple Airlines Logo
9:45 am - 6:43 pm
MDE
-
SFO
10h 58m
1 stop
$393Multiple Airlines
Wed, Apr 15 - Wed, Apr 22
Multiple Airlines Logo
4:45 pm - 9:10 pm
SFO
-
MDE
26h 25m
1 stop
Multiple Airlines Logo
9:45 am - 6:43 pm
MDE
-
SFO
10h 58m
1 stop
$394Multiple Airlines
Tue, Apr 7 - Tue, Apr 21
United Airlines Logo
4:45 pm - 9:10 pm
SFO
-
MDE
26h 25m
1 stop
United Airlines Logo
9:45 am - 6:43 pm
MDE
-
SFO
10h 58m
1 stop
$397United Airlines
Tue, Apr 7 - Tue, Apr 21
United Airlines Logo
11:59 pm - 10:05 pm
SFO
-
MDE
19h 06m
1 stop
United Airlines Logo
10:45 am - 11:59 pm
MDE
-
SFO
16h 14m
1 stop
$426United Airlines
Sun, Feb 15 - Fri, Feb 27
Copa Airlines Logo
1:23 am - 5:07 pm
SFO
-
BOG
13h 44m
1 stop
Copa Airlines Logo
12:08 pm - 11:40 pm
BOG
-
SFO
13h 32m
1 stop
$447Copa Airlines
Fri, Apr 10 - Sun, Apr 19
Copa Airlines Logo
12:42 am - 12:20 am
SFO
-
BOG
20h 38m
1 stop
Copa Airlines Logo
10:40 am - 11:20 pm
BOG
-
SFO
15h 40m
1 stop
$448Copa Airlines
Sun, Jan 25 - Fri, Feb 6
LATAM Airlines Logo
6:28 pm - 5:25 pm
SFO
-
SCL
19h 57m
2 stops
LATAM Airlines Logo
11:00 pm - 4:57 pm
SCL
-
SFO
20h 57m
2 stops
$583LATAM Airlines
Mon, Apr 20 - Mon, May 4
LATAM Airlines Logo
8:00 am - 7:15 am
SFO
-
SCL
20h 15m
1 stop
LATAM Airlines Logo
11:00 pm - 4:57 pm
SCL
-
SFO
20h 57m
2 stops
$608LATAM Airlines
Mon, Apr 20 - Mon, May 4
American Airlines Logo
11:32 am - 8:10 am
SFO
-
GRU
16h 38m
1 stop
American Airlines Logo
10:35 pm - 1:09 pm
GRU
-
SFO
18h 34m
1 stop
$626American Airlines
Sun, Mar 8 - Tue, Mar 24

Avianca flights from San Francisco to South America

Our best Avianca deals on San Francisco to South America flight tickets
Avianca
Jan 25
SFO11:10 pmSan Francisco
10h 45m
1 stop
MDE12:55 pmMedellín Jose Maria Cordova Intl
Feb 24
MDE2:10 pmMedellín Jose Maria Cordova Intl
12h 10m
1 stop
SFO11:20 pmSan Francisco
$390
Avianca
Mar 7
SFO1:35 amSan Francisco
14h 35m
2 stops
MDE7:10 pmMedellín Jose Maria Cordova Intl
Mar 14
MDE2:10 pmMedellín Jose Maria Cordova Intl
11h 30m
1 stop
SFO11:40 pmSan Francisco
$396
Avianca
Mar 7
SFO1:35 amSan Francisco
13h 40m
2 stops
MDE6:15 pmMedellín Jose Maria Cordova Intl
Mar 14
MDE10:40 amMedellín Jose Maria Cordova Intl
15h 00m
2 stops
SFO11:40 pmSan Francisco
$402

United Airlines flights from San Francisco to South America

Our best United Airlines deals on San Francisco to South America flight tickets
United Airlines
Apr 7
SFO4:45 pmSan Francisco
26h 25m
1 stop
MDE9:10 pmMedellín Jose Maria Cordova Intl
Apr 21
MDE9:45 amMedellín Jose Maria Cordova Intl
10h 58m
1 stop
SFO6:43 pmSan Francisco
$397
United Airlines
Jan 19
SFO5:00 amSan Francisco
14h 05m
1 stop
MDE10:05 pmMedellín Jose Maria Cordova Intl
Feb 6
MDE10:45 amMedellín Jose Maria Cordova Intl
16h 14m
1 stop
SFO11:59 pmSan Francisco
$398
United Airlines
Feb 15
SFO11:59 pmSan Francisco
19h 06m
1 stop
MDE10:05 pmMedellín Jose Maria Cordova Intl
Feb 27
MDE10:45 amMedellín Jose Maria Cordova Intl
16h 14m
1 stop
SFO11:59 pmSan Francisco
$426

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 15, 2026.
Use the filters below to find and compare flights from San Francisco to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

Sun 1/25

11:10 pm-12:55 pm

1 stop10h 45m

Medellín Jose Maria Cordova Intl

Tue 2/24

2:10 pm-11:20 pm

1 stop12h 10m

$390

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

Wed 4/15

12:45 am-9:10 pm

1 stop18h 25m

Medellín Jose Maria Cordova Intl

Wed 4/22

9:45 am-6:43 pm

1 stop10h 58m

$393

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

Tue 4/7

4:45 pm-9:10 pm

1 stop26h 25m

Medellín Jose Maria Cordova Intl

Tue 4/21

9:45 am-6:43 pm

1 stop10h 58m

$394

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

Tue 4/7

4:45 pm-9:10 pm

1 stop26h 25m

Medellín Jose Maria Cordova Intl

Tue 4/21

9:45 am-6:43 pm

1 stop10h 58m

$397

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

Sun 2/15

11:59 pm-10:05 pm

1 stop19h 06m

Medellín Jose Maria Cordova Intl

Fri 2/27

10:45 am-11:59 pm

1 stop16h 14m

$426

San FranciscoBogotá

SFO - BOG

SFOBOG

San Francisco

Fri 4/10

1:23 am-5:07 pm

1 stop13h 44m

Bogotá El Dorado

Sun 4/19

12:08 pm-11:40 pm

1 stop13h 32m

$447

San FranciscoBogotá

SFO - BOG

SFOBOG

San Francisco

Sun 1/25

12:42 am-12:20 am

1 stop20h 38m

Bogotá El Dorado

Fri 2/6

10:40 am-11:20 pm

1 stop15h 40m

$448

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 4/20

6:28 pm-5:25 pm

2 stops19h 57m

Santiago Arturo Merino Benitez

Mon 5/4

11:00 pm-4:57 pm

2 stops20h 57m

$583

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 4/20

8:00 am-7:15 am

1 stop20h 15m

Santiago Arturo Merino Benitez

Mon 5/4

11:00 pm-4:57 pm

2 stops20h 57m

$608

San FranciscoSao Paulo

SFO - GRU

SFOGRU

San Francisco

Sun 3/8

11:32 am-8:10 am

1 stop16h 38m

Sao Paulo Guarulhos Intl

Tue 3/24

10:35 pm-1:09 pm

1 stop18h 34m

$626

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from San Francisco to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

In general, September is the cheapest month to fly from San Francisco to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $621. If you aren’t able to travel during the month of September, then book flights to South America from San Francisco during February instead. Flights to South America in February, while not as cheap as those in September, still average around $638.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $702 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from San Francisco for as low as $650 on momondo.

Can stopping save me money on San Francisco to South America flights?

You could potentially save up to 4% on your flight if you consider stops on a San Francisco to South America flight.

Cheap San Francisco to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to South America

Fastest flight time

9h 30m

Direct flights

None
The fastest flight from San Francisco to South America takes 9h 30m
There are no direct flights from San Francisco to South America. There are no popular flight routes from San Francisco to South America.
Search flight deals

  • When did momondo last update prices for flights from San Francisco Airport to South America?

    Prices for flights from San Francisco Airport to South America are updated daily.

  • How many operators does momondo search for flights from San Francisco Airport to South America?

  • How old do you have to be to fly from San Francisco Airport to South America?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Francisco Airport to South America.

  • What documentation or ID do you need to fly to South America?

    The necessary travel and health documents for your South America trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from San Francisco to South America

Compare and see reviews for airlines that fly from San Francisco to South America with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $214Free CancellationRating
7.4
9,164 reviews
Search United Airlines flights
JetBluePriceFrom $224Free CancellationRating
7.2
2,887 reviews
Search JetBlue flights
LATAM AirlinesPriceFrom $258Free CancellationRating
7.5
1,906 reviews
Search LATAM Airlines flights
DeltaPriceFrom $280Free CancellationRating
7.9
8,051 reviews
Search Delta flights
Copa AirlinesPriceFrom $303Free CancellationRating
7.6
1,559 reviews
Search Copa Airlines flights
AviancaPriceFrom $310Free CancellationRating
6.6
2,492 reviews
Search Avianca flights
AeromexicoPriceFrom $453Free CancellationRating
7.4
1,596 reviews
Search Aeromexico flights
American AirlinesPriceFrom $463Free CancellationRating
7.2
11,136 reviews
Search American Airlines flights
Air CanadaPriceFrom $531Free CancellationRating
7.1
10,624 reviews
Search Air Canada flights
GOLPriceFrom $668Free CancellationRating
7.3
1,151 reviews
Search GOL flights

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to South America?

It is quick and easy to find San Francisco to South America flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South America that suits you.

Can I find flights from San Francisco to South America with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for San Francisco to South America flights to just show those with flexible booking policies.

How can momondo help me find flights from San Francisco to South America?

momondo provides multiple filters to help you find the best flight to South America from San Francisco. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from San Francisco to South America right now. Can momondo alert me if prices change?

If you are not ready to book a flight from San Francisco to South America now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South America and let you know when they change.

An easier way to manage your South America trip

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Find better results for your trip to South America

Popular cities in South America

Popular flights according to clicks in the last 7 days on momondo
Flights to Limafrom $188
Flights to Buenos Airesfrom $491
Flights to Sao Paulofrom $377
Flights to Bogotáfrom $165
Flights to Rio de Janeirofrom $447
Flights to Medellínfrom $178
Flights to Santiagofrom $332
Flights to Cartagenafrom $170
Flights to Quitofrom $232
Flights to Cuscofrom $369
Flights to Guayaquilfrom $177
Flights to Califrom $200