What is the cheapest airline that flies from San Francisco to South America?

Copa Airlines, American Airlines, and United Airlines are the most popular carriers operating from San Francisco to South America

What airlines fly to South America?

Copa Airlines, Avianca and United Airlines are the top three most popular airlines that fly to South America from San Francisco according to our data. Copa Airlines is the first choice among our users, with 33% of people opting to fly with this airline when traveling to South America. Keep in mind that there are 10 different airlines that fly to South America on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from San Francisco Airport to South America?

Prices for flights from San Francisco Airport to South America are updated daily.

How many operators does momondo search for flights from San Francisco Airport to South America?

There are 10 operators available for flights from San Francisco Airport to South America as of March 2026.

How old do you have to be to fly from San Francisco Airport to South America?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Francisco Airport to South America.

What documentation or ID do you need to fly to South America?

The necessary travel and health documents for your South America trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$167 Cheap Flights from San Francisco to South America in 2026

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Find the cheapest flights from San Francisco to South America

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

11:55 pm - 1:10 pm

SFO

MDE

11h 15m

1 stop

2:10 pm - 10:35 pm

MDE

SFO

10h 25m

1 stop

$377Avianca

Thu, May 7 - Thu, May 14

11:55 pm - 1:10 pm

SFO

MDE

11h 15m

1 stop

2:10 pm - 11:55 pm

MDE

SFO

11h 45m

1 stop

$380Avianca

Thu, May 7 - Sat, May 16

11:55 pm - 1:10 pm

SFO

MDE

11h 15m

1 stop

9:30 am - 10:35 pm

MDE

SFO

15h 05m

2 stops

$382Avianca

Thu, May 7 - Thu, May 14

8:37 pm - 9:40 am

SFO

MDE

11h 03m

1 stop

12:40 pm - 11:40 pm

MDE

SFO

13h 00m

1 stop

$389Copa Airlines

Thu, Apr 9 - Mon, Apr 20

6:00 am - 7:15 pm

SFO

BOG

11h 15m

1 stop

8:40 am - 8:24 pm

BOG

SFO

13h 44m

2 stops

$502LATAM Airlines

Wed, Apr 15 - Sat, Apr 25

1:12 am - 5:07 pm

SFO

BOG

13h 55m

1 stop

7:00 am - 11:40 pm

BOG

SFO

18h 40m

1 stop

$503Copa Airlines

Mon, May 4 - Sat, May 16

11:59 pm - 11:00 pm

SFO

LIM

21h 01m

1 stop

12:55 am - 11:59 pm

LIM

SFO

25h 04m

1 stop

$522United Airlines

Sun, Apr 12 - Tue, May 12

4:15 pm - 10:00 pm

SFO

LIM

27h 45m

2 stops

1:30 pm - 1:21 pm

LIM

SFO

25h 51m

2 stops

$537LATAM Airlines

Fri, Aug 14 - Mon, Aug 31

11:10 am - 9:50 am

SFO

GRU

18h 40m

1 stop

9:00 pm - 8:47 pm

GRU

SFO

27h 47m

1 stop

$761Air Canada

Sun, Sep 13 - Mon, Sep 21

11:46 pm - 9:50 am

SFO

GRU

30h 04m

1 stop

9:00 pm - 5:29 pm

GRU

SFO

24h 29m

2 stops

$766Air Canada

Sat, Sep 19 - Wed, Sep 30

Avianca flights from San Francisco to South America

Our best Avianca deals on San Francisco to South America flight tickets

Avianca

May 7

SFO11:55 pmSan Francisco

11h 15m

1 stop

MDE1:10 pmMedellín Jose Maria Cordova Intl

May 14

MDE2:10 pmMedellín Jose Maria Cordova Intl

10h 25m

1 stop

SFO10:35 pmSan Francisco

$377

Avianca

May 7

SFO11:55 pmSan Francisco

11h 15m

1 stop

MDE1:10 pmMedellín Jose Maria Cordova Intl

May 16

MDE2:10 pmMedellín Jose Maria Cordova Intl

11h 45m

1 stop

SFO11:55 pmSan Francisco

$380

Avianca

May 7

SFO11:55 pmSan Francisco

11h 15m

1 stop

MDE1:10 pmMedellín Jose Maria Cordova Intl

May 14

MDE9:30 amMedellín Jose Maria Cordova Intl

15h 05m

2 stops

SFO10:35 pmSan Francisco

$382

Delta flights from San Francisco to South America

Our best Delta deals on San Francisco to South America flight tickets

Delta

May 9

SFO11:58 pmSan Francisco

11h 42m

1 stop

BOG1:40 pmBogotá El Dorado

Jun 2

BOG9:00 amBogotá El Dorado

16h 24m

1 stop

SFO11:24 pmSan Francisco

$509

Delta

Mar 28

SFO2:20 pmSan Francisco

21h 20m

1 stop

BOG1:40 pmBogotá El Dorado

Apr 6

BOG9:00 amBogotá El Dorado

16h 19m

1 stop

SFO11:19 pmSan Francisco

$515

Delta

Mar 31

SFO11:35 pmSan Francisco

17h 10m

2 stops

BOG6:45 pmBogotá El Dorado

Apr 4

BOG2:55 pmBogotá El Dorado

21h 57m

1 stop

SFO10:52 amSan Francisco

$520

momondo Fare Finder

Use the filters below to find and compare flights from San Francisco to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Quickest round-trip

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

Thu 5/7

11:55 pm-1:10 pm

1 stop11h 15m

Medellín Jose Maria Cordova Intl

Thu 5/14

2:10 pm-10:35 pm

1 stop10h 25m

$377

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

Thu 5/7

11:55 pm-1:10 pm

1 stop11h 15m

Medellín Jose Maria Cordova Intl

Sat 5/16

2:10 pm-11:55 pm

1 stop11h 45m

$380

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

Thu 5/7

11:55 pm-1:10 pm

1 stop11h 15m

Medellín Jose Maria Cordova Intl

Thu 5/14

9:30 am-10:35 pm

2 stops15h 05m

$382

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

Thu 4/9

8:37 pm-9:40 am

1 stop11h 03m

Medellín Jose Maria Cordova Intl

Mon 4/20

12:40 pm-11:40 pm

1 stop13h 00m

$389

San FranciscoBogotá

SFO - BOG

SFOBOG

San Francisco

Wed 4/15

6:00 am-7:15 pm

1 stop11h 15m

Bogotá El Dorado

Sat 4/25

8:40 am-8:24 pm

2 stops13h 44m

$502

San FranciscoBogotá

SFO - BOG

SFOBOG

San Francisco

Mon 5/4

1:12 am-5:07 pm

1 stop13h 55m

Bogotá El Dorado

Sat 5/16

7:00 am-11:40 pm

1 stop18h 40m

$503

San FranciscoLima

SFO - LIM

SFOLIM

San Francisco

Sun 4/12

11:59 pm-11:00 pm

1 stop21h 01m

Lima J Chavez Intl

Tue 5/12

12:55 am-11:59 pm

1 stop25h 04m

$522

San FranciscoLima

SFO - LIM

SFOLIM

San Francisco

Fri 8/14

4:15 pm-10:00 pm

2 stops27h 45m

Lima J Chavez Intl

Mon 8/31

1:30 pm-1:21 pm

2 stops25h 51m

$537

San FranciscoSao Paulo

SFO - GRU

SFOGRU

San Francisco

Sun 9/13

11:10 am-9:50 am

1 stop18h 40m

Sao Paulo Guarulhos Intl

Mon 9/21

9:00 pm-8:47 pm

1 stop27h 47m

$761

San FranciscoSao Paulo

SFO - GRU

SFOGRU

San Francisco

Sat 9/19

11:46 pm-9:50 am

1 stop30h 04m

Sao Paulo Guarulhos Intl

Wed 9/30

9:00 pm-5:29 pm

2 stops24h 29m

$766

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from San Francisco to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South America?

In general, February is the cheapest month to fly from San Francisco to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $612. If you aren’t able to travel during the month of February, then book flights to South America from San Francisco during October instead. Flights to South America in October, while not as cheap as those in February, still average around $621.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $691 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from San Francisco for as low as $632 on momondo.

Can stopping save me money on San Francisco to South America flights?

You could potentially save up to 20% on your flight if you consider stops on a San Francisco to South America flight.

Cheap San Francisco to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to South America

Fastest flight time	9h 38m
Direct flights	None

The fastest flight from San Francisco to South America takes 9h 38m

There are no direct flights from San Francisco to South America. There are no popular flight routes from San Francisco to South America.

Search flight deals

When did momondo last update prices for flights from San Francisco Airport to South America?
Prices for flights from San Francisco Airport to South America are updated daily.
How many operators does momondo search for flights from San Francisco Airport to South America?
There are 10 operators available for flights from San Francisco Airport to South America as of March 2026.
How old do you have to be to fly from San Francisco Airport to South America?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Francisco Airport to South America.
What documentation or ID do you need to fly to South America?
The necessary travel and health documents for your South America trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from San Francisco to South America

Compare and see reviews for airlines that fly from San Francisco to South America with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $214	Free Cancellation	Rating 7.4 9,469 reviews	Search United Airlines flights
JetBlue	PriceFrom $224	Free Cancellation	Rating 7.2 2,904 reviews	Search JetBlue flights
LATAM Airlines	PriceFrom $258	Free Cancellation	Rating 7.4 1,908 reviews	Search LATAM Airlines flights
Copa Airlines	PriceFrom $269	Free Cancellation	Rating 7.5 1,577 reviews	Search Copa Airlines flights
Delta	PriceFrom $282	Free Cancellation	Rating 7.9 8,322 reviews	Search Delta flights
Avianca	PriceFrom $312	Free Cancellation	Rating 6.5 2,505 reviews	Search Avianca flights
GOL	PriceFrom $415	Free Cancellation	Rating 7.3 1,195 reviews	Search GOL flights
Aeromexico	PriceFrom $453	Free Cancellation	Rating 7.4 1,560 reviews	Search Aeromexico flights
American Airlines	PriceFrom $459	Free Cancellation	Rating 7.1 11,491 reviews	Search American Airlines flights
Air Canada	PriceFrom $565	Free Cancellation	Rating 7.1 10,836 reviews	Search Air Canada flights

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to South America?

It is quick and easy to find San Francisco to South America flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South America that suits you.

Can I find flights from San Francisco to South America with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for San Francisco to South America flights to just show those with flexible booking policies.

How can momondo help me find flights from San Francisco to South America?

momondo provides multiple filters to help you find the best flight to South America from San Francisco. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from San Francisco to South America right now. Can momondo alert me if prices change?

If you are not ready to book a flight from San Francisco to South America now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South America and let you know when they change.