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Cheap flights from San Francisco to Knoxville from $129

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from San Francisco to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
8:00 am - 5:28 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
6h 28m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:26 am - 2:20 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
9h 54m1 stop Detroit Metropolitan Wayne County
$257Delta
Wed, Oct 28 - Sat, Oct 31
Multiple Airlines Logo
3:05 pm - 8:39 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
26h 34m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
9:33 pm - 12:52 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
18h 19m1 stop Las Vegas Harry Reid Intl
$263Multiple Airlines
Wed, Oct 28 - Thu, Nov 5
Multiple Airlines Logo
3:05 pm - 9:39 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
27h 34m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
9:33 pm - 12:52 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
18h 19m1 stop Las Vegas Harry Reid Intl
$268Multiple Airlines
Sat, Oct 31 - Thu, Nov 5
Delta Logo
9:55 pm - 9:34 amSFO  San Francisco-TYS Knoxville McGhee Tyson
8h 39m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:23 pm - 10:59 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
7h 36m1 stop Atlanta Hartsfield-Jackson
$270Delta
Mon, Oct 5 - Wed, Oct 7
Multiple Airlines Logo
7:14 pm - 8:39 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
22h 25m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
9:29 pm - 8:19 amTYS  Knoxville McGhee Tyson-SFO San Francisco
13h 50m1 stop Las Vegas Harry Reid Intl
$276Multiple Airlines
Wed, Oct 28 - Sun, Nov 1
American Airlines Logo
6:47 am - 4:36 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
6h 49m1 stop Dallas/Fort Worth
American Airlines Logo
4:49 pm - 11:07 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
9h 18m1 stop Charlotte Douglas
$325American Airlines
Wed, Oct 14 - Wed, Oct 21
Delta Logo
10:35 am - 11:02 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
9h 27m2 stops Seattle/Tacoma Intl Minneapolis St Paul
Delta Logo
5:40 am - 10:26 amTYS  Knoxville McGhee Tyson-SFO San Francisco
7h 46m1 stop Atlanta Hartsfield-Jackson
$350Delta
Wed, Oct 28 - Sat, Oct 31
American Airlines Logo
12:42 pm - 11:18 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
7h 36m1 stop Dallas/Fort Worth
American Airlines Logo
6:01 am - 12:23 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
9h 22m1 stop Charlotte Douglas
$363American Airlines
Thu, Oct 29 - Tue, Nov 3
United Airlines Logo
6:15 am - 3:49 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
6h 34m1 stop Denver Intl
United Airlines Logo
6:00 am - 10:30 amTYS  Knoxville McGhee Tyson-SFO San Francisco
7h 30m1 stop Chicago O'Hare Intl
$363United Airlines
Wed, Oct 21 - Thu, Oct 22
United Airlines Logo
6:15 am - 3:54 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
6h 39m1 stop Denver Intl
United Airlines Logo
6:45 am - 1:30 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
9h 45m1 stop Chicago O'Hare Intl
$363United Airlines
Sat, Oct 24 - Tue, Nov 3

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United Airlines flights from San Francisco to Knoxville

Our best United Airlines deals on San Francisco to Knoxville flight tickets
United Airlines
Sep 29
SFO12:45 pmSan Francisco
8h 14m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Sep 30
TYS6:00 amKnoxville McGhee Tyson
7h 30m
1 stop
SFO10:30 amSan Francisco
$378
United Airlines
Oct 27
SFO11:20 pmSan Francisco
9h 10m
1 stop
TYS11:30 amKnoxville McGhee Tyson
Oct 29
TYS9:45 amKnoxville McGhee Tyson
11h 02m
1 stop
SFO5:47 pmSan Francisco
$380
United Airlines
Sep 25
SFO11:10 pmSan Francisco
8h 27m
1 stop
TYS10:37 amKnoxville McGhee Tyson
Sep 26
TYS3:45 pmKnoxville McGhee Tyson
7h 29m
1 stop
SFO8:14 pmSan Francisco
$457

American Airlines flights from San Francisco to Knoxville

Our best American Airlines deals on San Francisco to Knoxville flight tickets
American Airlines
Oct 14
SFO6:47 amSan Francisco
6h 49m
1 stop
TYS4:36 pmKnoxville McGhee Tyson
Oct 21
TYS4:49 pmKnoxville McGhee Tyson
9h 18m
1 stop
SFO11:07 pmSan Francisco
$325
American Airlines
Oct 24
SFO8:00 amSan Francisco
8h 28m
1 stop
TYS7:28 pmKnoxville McGhee Tyson
Nov 4
TYS7:30 pmKnoxville McGhee Tyson
8h 09m
1 stop
SFO12:39 amSan Francisco
$376
American Airlines
Nov 19
SFO2:01 pmSan Francisco
6h 31m
1 stop
TYS11:32 pmKnoxville McGhee Tyson
Nov 23
TYS6:05 pmKnoxville McGhee Tyson
8h 05m
1 stop
SFO11:10 pmSan Francisco
$395

momondo Fare Finder

 
Use the filters below to find and compare flights from San Francisco to Knoxville that are best for you.

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Route

Depart

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Price

Cheapest round-trip

San FranciscoKnoxville

SFO San Francisco - TYS Knoxville McGhee Tyson

SFOTYS

San Francisco

Wed 10/28

8:00 am-5:28 pm

1 stop6h 28m

Knoxville McGhee Tyson

Sat 10/31

7:26 am-2:20 pm

1 stop9h 54m

$257

San FranciscoKnoxville

SFO San Francisco - TYS Knoxville McGhee Tyson

SFOTYS

San Francisco

Wed 10/28

3:05 pm-8:39 pm

1 stop26h 34m

Knoxville McGhee Tyson

Thu 11/5

9:33 pm-12:52 pm

1 stop18h 19m

$263

San FranciscoKnoxville

SFO San Francisco - TYS Knoxville McGhee Tyson

SFOTYS

San Francisco

Sat 10/31

3:05 pm-9:39 pm

1 stop27h 34m

Knoxville McGhee Tyson

Thu 11/5

9:33 pm-12:52 pm

1 stop18h 19m

$268

San FranciscoKnoxville

SFO San Francisco - TYS Knoxville McGhee Tyson

SFOTYS

San Francisco

Mon 10/5

9:55 pm-9:34 am

1 stop8h 39m

Knoxville McGhee Tyson

Wed 10/7

6:23 pm-10:59 pm

1 stop7h 36m

$270

San FranciscoKnoxville

SFO San Francisco - TYS Knoxville McGhee Tyson

SFOTYS

San Francisco

Wed 10/28

7:14 pm-8:39 pm

1 stop22h 25m

Knoxville McGhee Tyson

Sun 11/1

9:29 pm-8:19 am

1 stop13h 50m

$276

San FranciscoKnoxville

SFO San Francisco - TYS Knoxville McGhee Tyson

SFOTYS

San Francisco

Wed 10/14

6:47 am-4:36 pm

1 stop6h 49m

Knoxville McGhee Tyson

Wed 10/21

4:49 pm-11:07 pm

1 stop9h 18m

$325

San FranciscoKnoxville

SFO San Francisco - TYS Knoxville McGhee Tyson

SFOTYS

San Francisco

Wed 10/28

10:35 am-11:02 pm

2 stops9h 27m

Knoxville McGhee Tyson

Sat 10/31

5:40 am-10:26 am

1 stop7h 46m

$350

San FranciscoKnoxville

SFO San Francisco - TYS Knoxville McGhee Tyson

SFOTYS

San Francisco

Thu 10/29

12:42 pm-11:18 pm

1 stop7h 36m

Knoxville McGhee Tyson

Tue 11/3

6:01 am-12:23 pm

1 stop9h 22m

$363
Quickest round-trip

San FranciscoKnoxville

SFO San Francisco - TYS Knoxville McGhee Tyson

SFOTYS

San Francisco

Wed 10/21

6:15 am-3:49 pm

1 stop6h 34m

Knoxville McGhee Tyson

Thu 10/22

6:00 am-10:30 am

1 stop7h 30m

$363

San FranciscoKnoxville

SFO San Francisco - TYS Knoxville McGhee Tyson

SFOTYS

San Francisco

Sat 10/24

6:15 am-3:54 pm

1 stop6h 39m

Knoxville McGhee Tyson

Tue 11/3

6:45 am-1:30 pm

1 stop9h 45m

$363

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from San Francisco to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Francisco and Knoxville?

Prices are currently low for flights on this route.

Typical prices usually range from $388 to $585.
The lowest price recently found on this route was $257.

What is the cheapest month to fly to Knoxville?

The month of February is, on average, the cheapest month to fly to Knoxville from San Francisco, with most prices found around $409. If you aren’t able to travel during the month of February, then book flights to Knoxville from San Francisco during January instead. Flights to Knoxville in January, while not as cheap as those in February, still average around $429.

How far in advance should I book a flight from San Francisco to Knoxville?

You are more likely to see cheaper flights to Knoxville from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $509 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from San Francisco for as low as $334 on momondo.

How have San Francisco to Knoxville flight prices changed over time?

As of September 2026, prices for San Francisco to Knoxville flights are approximately 120% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Knoxville (SFO to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Knoxville

Best Price Found

$129

Fastest flight time

6h 10m

Direct flights

None
The best one-way flight to Knoxville from San Francisco in the past 72 hours is $129. The best round-trip flight deal from San Francisco to Knoxville found on momondo in the last 72 hours is $257.
The fastest flight from San Francisco to Knoxville takes 6h 10m
There are no direct flights from San Francisco to Knoxville. There are no popular flight routes from San Francisco to Knoxville.
Search flight deals

Frequently asked questions about flying from San Francisco to Knoxville

  • How far is San Francisco to Knoxville McGhee Tyson by plane?

    The straight-line distance from San Francisco to Knoxville McGhee Tyson is 2114.2 mi. In terms of flight time, this usually takes a little over 6h 10m.

  • When did momondo last update prices for flights from San Francisco Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Francisco Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Francisco Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Francisco Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from San Francisco to Knoxville?

Best airlines flying from San Francisco to Knoxville

Compare and see reviews for airlines that fly from San Francisco to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $220Free CancellationRating
5.6
2,600 reviews
Search Frontier flights
DeltaPriceFrom $328Free CancellationRating
7.8
8,568 reviews
Search Delta flights
United AirlinesPriceFrom $328Free CancellationRating
7.4
10,208 reviews
Search United Airlines flights
American AirlinesPriceFrom $328Free CancellationRating
7.1
12,056 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Alcoa
Corbin
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Dandridge
Lenoir City
Clinton
Rockford
Jefferson City

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Francisco to Knoxville for you.

Can I find flights from San Francisco to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for San Francisco to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from San Francisco to Knoxville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from San Francisco to Knoxville.

I’m not ready to book a flight from San Francisco to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Francisco to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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