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Cheap flights from San Francisco to Knoxville from $139

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Knoxville departing on 8/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from San Francisco to Knoxville

Cheap round-trip flights

Frontier Logo
10:49 am - 4:18 pmSFO-TYS
26h 29m1 stop
Frontier Logo
8:22 pm - 7:46 amTYS-SFO
14h 24m1 stop
$265Frontier
Find Deal
Sat, Oct 4 - Thu, Oct 9
Frontier Logo
10:49 am - 4:18 pmSFO-TYS
26h 29m1 stop
Frontier Logo
8:35 pm - 10:30 pmTYS-SFO
28h 55m1 stop
$267Frontier
Find Deal
Sat, Sep 6 - Mon, Sep 15
United Airlines Logo
10:45 pm - 10:29 amSFO-TYS
8h 44m1 stop
United Airlines Logo
4:40 pm - 8:54 pmTYS-SFO
7h 14m1 stop
$304United Airlines
Find Deal
Fri, Sep 26 - Sat, Sep 27
Delta Logo
6:15 am - 6:26 pmSFO-TYS
9h 11m1 stop
Delta Logo
12:25 pm - 5:47 pmTYS-SFO
8h 22m1 stop
$309Delta
Find Deal
Mon, Sep 15 - Wed, Sep 17
Delta Logo
6:15 am - 3:34 pmSFO-TYS
6h 19m1 stop
Delta Logo
4:19 pm - 8:25 pmTYS-SFO
7h 06m1 stop
$339Delta
Find Deal
Wed, Aug 13 - Thu, Aug 21
United Airlines Logo
11:44 pm - 10:05 amSFO-TYS
7h 21m1 stop
United Airlines Logo
7:00 am - 12:10 pmTYS-SFO
8h 10m1 stop
$363United Airlines
Find Deal
Thu, Nov 6 - Tue, Nov 11
Logo
11:59 pm - 4:12 pmSFO-TYS
13h 13m1 stop
Logo
10:54 am - 5:12 pmTYS-SFO
33h 18m3 stops
$416
Find Deal
Sun, Aug 10 - Wed, Aug 20
American Airlines Logo
11:23 am - 11:51 pmSFO-TYS
9h 28m1 stop
American Airlines Logo
5:37 pm - 10:09 pmTYS-SFO
7h 32m1 stop
$424American Airlines
Find Deal
Thu, Oct 23 - Sun, Oct 26
American Airlines Logo
12:45 am - 11:30 amSFO-TYS
7h 45m1 stop
American Airlines Logo
12:51 pm - 6:01 pmTYS-SFO
8h 10m1 stop
$442American Airlines
Find Deal
Thu, Aug 28 - Fri, Sep 5
Logo
6:18 pm - 10:26 pmSFO-TYS
25h 08m2 stops
Logo
7:20 am - 5:18 pmTYS-SFO
12h 58m2 stops
$468
Find Deal
Thu, Nov 6 - Mon, Nov 10

Frontier flights from San Francisco to Knoxville

Our best Frontier deals on San Francisco to Knoxville flight tickets
Frontier
Oct 4
SFO10:49 amSan Francisco
26h 29m
1 stop
TYS4:18 pmKnoxville McGhee Tyson
Oct 9
TYS8:22 pmKnoxville McGhee Tyson
14h 24m
1 stop
SFO7:46 amSan Francisco
$265
Find similar
Frontier
Sep 6
SFO10:49 amSan Francisco
26h 29m
1 stop
TYS4:18 pmKnoxville McGhee Tyson
Sep 15
TYS8:35 pmKnoxville McGhee Tyson
28h 55m
1 stop
SFO10:30 pmSan Francisco
$267
Find similar
Frontier
Aug 10
SFO6:37 amSan Francisco
6h 52m
1 stop
TYS4:29 pmKnoxville McGhee Tyson
Aug 21
TYS8:36 pmKnoxville McGhee Tyson
6h 43m
1 stop
SFO12:19 amSan Francisco
$278
Find similar

American Airlines flights from San Francisco to Knoxville

Our best American Airlines deals on San Francisco to Knoxville flight tickets
American Airlines
Aug 2
SFO12:13 pmSan Francisco
8h 46m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Aug 13
TYS3:04 pmKnoxville McGhee Tyson
9h 29m
1 stop
SFO9:33 pmSan Francisco
$412
Find similar
American Airlines
Oct 23
SFO11:23 amSan Francisco
9h 28m
1 stop
TYS11:51 pmKnoxville McGhee Tyson
Oct 26
TYS5:37 pmKnoxville McGhee Tyson
7h 32m
1 stop
SFO10:09 pmSan Francisco
$424
Find similar
American Airlines
Aug 28
SFO12:45 amSan Francisco
7h 45m
1 stop
TYS11:30 amKnoxville McGhee Tyson
Sep 5
TYS12:51 pmKnoxville McGhee Tyson
8h 10m
1 stop
SFO6:01 pmSan Francisco
$442
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from San Francisco to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sat 10/4

10:49 am-4:18 pm

1 stop26h 29m

Knoxville McGhee Tyson

Thu 10/9

8:22 pm-7:46 am

1 stop14h 24m

$265

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sat 9/6

10:49 am-4:18 pm

1 stop26h 29m

Knoxville McGhee Tyson

Mon 9/15

8:35 pm-10:30 pm

1 stop28h 55m

$267

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Fri 9/26

10:45 pm-10:29 am

1 stop8h 44m

Knoxville McGhee Tyson

Sat 9/27

4:40 pm-8:54 pm

1 stop7h 14m

$304

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 9/15

6:15 am-6:26 pm

1 stop9h 11m

Knoxville McGhee Tyson

Wed 9/17

12:25 pm-5:47 pm

1 stop8h 22m

$309

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Wed 8/13

6:15 am-3:34 pm

1 stop6h 19m

Knoxville McGhee Tyson

Thu 8/21

4:19 pm-8:25 pm

1 stop7h 06m

$339

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 11/6

11:44 pm-10:05 am

1 stop7h 21m

Knoxville McGhee Tyson

Tue 11/11

7:00 am-12:10 pm

1 stop8h 10m

$363

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sun 8/10

11:59 pm-4:12 pm

1 stop13h 13m

Knoxville McGhee Tyson

Wed 8/20

10:54 am-5:12 pm

3 stops33h 18m

$416

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 10/23

11:23 am-11:51 pm

1 stop9h 28m

Knoxville McGhee Tyson

Sun 10/26

5:37 pm-10:09 pm

1 stop7h 32m

$424

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 8/28

12:45 am-11:30 am

1 stop7h 45m

Knoxville McGhee Tyson

Fri 9/5

12:51 pm-6:01 pm

1 stop8h 10m

$442

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 11/6

6:18 pm-10:26 pm

2 stops25h 08m

Knoxville McGhee Tyson

Mon 11/10

7:20 am-5:18 pm

2 stops12h 58m

$468

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from San Francisco to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from San Francisco, with most prices found around $406. If you aren’t able to travel during the month of August, then book flights to Knoxville from San Francisco during February instead. Flights to Knoxville in February, while not as cheap as those in August, still average around $415.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from San Francisco to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $425. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from San Francisco to Knoxville for around $555.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from San Francisco to Knoxville when you can find flight prices for as low as $453. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $514.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $481 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from San Francisco for as low as $378 on momondo.

How have San Francisco to Knoxville flight prices changed over time?

As of July 2025, prices for San Francisco to Knoxville flights are approximately 32% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Knoxville (SFO to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Knoxville

Best Price Found

$139

Fastest flight time

6h 19m

Direct flights

None

Airports in Knoxville

1 airport
The best one-way flight to Knoxville from San Francisco in the past 72 hours is $139. The best round-trip flight deal from San Francisco to Knoxville found on momondo in the last 72 hours is $265.
The fastest flight from San Francisco to Knoxville takes 6h 19m
There are no direct flights from San Francisco to Knoxville. Popular non-direct route for this connection is San Francisco Airport - Knoxville McGhee Tyson Airport.
There is 1 airport near Knoxville: Knoxville McGhee Tyson (TYS)
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  • How far is San Francisco to Knoxville McGhee Tyson by plane?

    The straight-line distance from San Francisco to Knoxville McGhee Tyson is 2114.7 mi. In terms of flight time, this usually takes a little over 6h 19m.

  • When did momondo last update prices for flights from San Francisco Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Francisco Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Francisco Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Francisco Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from San Francisco to Knoxville?

  • What is the most popular airline from San Francisco to Knoxville?

Best airlines flying from San Francisco to Knoxville

Compare and see reviews for airlines that fly from San Francisco to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $149Free CancellationRating
5.9
3,239 reviews
Search Frontier flights
DeltaPriceFrom $308Free CancellationRating
8.0
7,981 reviews
Search Delta flights
American AirlinesPriceFrom $308Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $315Free CancellationRating
7.4
8,900 reviews
Search United Airlines flights

  • United Airlines Flights From San Francisco to Knoxville

    United Airlines is one of the most popular airlines flying from San Francisco to Knoxville, operating 1 flight/week on average for this route. A good United Airlines flight deal for San Francisco to Knoxville starts from $315 round-trip, up to an average price of $573. Our users have rated United Airlines at 7.4/10.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Newport
Alcoa
Lenoir City
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Francisco to Knoxville for you.

Can I find flights from San Francisco to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for San Francisco to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from San Francisco to Knoxville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from San Francisco to Knoxville.

I’m not ready to book a flight from San Francisco to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Francisco to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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