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Cheap flights from San Francisco to Knoxville from $100

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Knoxville departing on 2/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Francisco to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
6:15 am - 7:18 pm
SFO
-
TYS
10h 03m
1 stop
Frontier Logo
6:51 pm - 12:28 am
TYS
-
SFO
8h 37m
1 stop
$200Frontier
Mon, Feb 23 - Fri, Feb 27
Frontier Logo
6:00 am - 3:28 pm
SFO
-
TYS
6h 28m
1 stop
Frontier Logo
4:28 pm - 12:22 am
TYS
-
SFO
10h 54m
1 stop
$221Frontier
Mon, Apr 13 - Sun, Apr 19
Frontier Logo
6:00 am - 3:28 pm
SFO
-
TYS
6h 28m
1 stop
Frontier Logo
4:20 pm - 12:23 am
TYS
-
SFO
11h 03m
1 stop
$260Frontier
Mon, Apr 6 - Mon, Apr 13
Frontier Logo
6:00 am - 3:28 pm
SFO
-
TYS
6h 28m
1 stop
Frontier Logo
4:20 pm - 12:23 am
TYS
-
SFO
11h 03m
1 stop
$281Frontier
Mon, Apr 6 - Fri, Apr 10
Multiple Airlines Logo
9:04 pm - 3:25 pm
SFO
-
TYS
15h 21m
1 stop
Multiple Airlines Logo
6:30 am - 7:14 pm
TYS
-
SFO
39h 44m
2 stops
$306Multiple Airlines
Sun, Mar 8 - Sun, Mar 15
Frontier Logo
6:00 am - 3:28 pm
SFO
-
TYS
6h 28m
1 stop
Frontier Logo
4:20 pm - 12:23 am
TYS
-
SFO
11h 03m
1 stop
$315Frontier
Mon, Apr 6 - Fri, Apr 10
Multiple Airlines Logo
6:29 pm - 10:36 am
SFO
-
TYS
13h 07m
2 stops
Multiple Airlines Logo
1:43 pm - 2:26 pm
TYS
-
SFO
27h 43m
1 stop
$324Multiple Airlines
Tue, Apr 7 - Mon, Apr 13
Frontier Logo
8:48 am - 6:06 pm
SFO
-
TYS
30h 18m
1 stop
Frontier Logo
8:13 pm - 6:20 pm
TYS
-
SFO
25h 07m
2 stops
$328Frontier
Thu, Feb 26 - Mon, Mar 2
American Airlines Logo
11:28 pm - 11:18 am
SFO
-
TYS
8h 50m
1 stop
American Airlines Logo
3:58 pm - 9:28 pm
TYS
-
SFO
8h 30m
1 stop
$329American Airlines
Sun, Apr 26 - Sat, May 2
Multiple Airlines Logo
9:04 pm - 3:25 pm
SFO
-
TYS
15h 21m
1 stop
Multiple Airlines Logo
6:30 am - 7:14 pm
TYS
-
SFO
39h 44m
2 stops
$330Multiple Airlines
Sun, Mar 8 - Sun, Mar 15

Delta flights from San Francisco to Knoxville

Our best Delta deals on San Francisco to Knoxville flight tickets
Delta
Apr 1
SFO5:50 amSan Francisco
7h 53m
1 stop
TYS4:43 pmKnoxville McGhee Tyson
Apr 10
TYS7:40 amKnoxville McGhee Tyson
10h 02m
1 stop
SFO2:42 pmSan Francisco
$383
Delta
Apr 1
SFO1:05 pmSan Francisco
17h 11m
2 stops
TYS9:16 amKnoxville McGhee Tyson
Apr 9
TYS7:40 amKnoxville McGhee Tyson
10h 02m
1 stop
SFO2:42 pmSan Francisco
$392
Delta
Apr 7
SFO4:03 pmSan Francisco
14h 13m
2 stops
TYS9:16 amKnoxville McGhee Tyson
Apr 9
TYS7:40 amKnoxville McGhee Tyson
10h 02m
1 stop
SFO2:42 pmSan Francisco
$393

Frontier flights from San Francisco to Knoxville

Our best Frontier deals on San Francisco to Knoxville flight tickets
Frontier
Feb 23
SFO6:15 amSan Francisco
10h 03m
1 stop
TYS7:18 pmKnoxville McGhee Tyson
Feb 27
TYS6:51 pmKnoxville McGhee Tyson
8h 37m
1 stop
SFO12:28 amSan Francisco
$200
Frontier
Apr 13
SFO6:00 amSan Francisco
6h 28m
1 stop
TYS3:28 pmKnoxville McGhee Tyson
Apr 19
TYS4:28 pmKnoxville McGhee Tyson
10h 54m
1 stop
SFO12:22 amSan Francisco
$221
Frontier
Apr 6
SFO6:00 amSan Francisco
6h 28m
1 stop
TYS3:28 pmKnoxville McGhee Tyson
Apr 13
TYS4:20 pmKnoxville McGhee Tyson
11h 03m
1 stop
SFO12:23 amSan Francisco
$260

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 8, 2026.
Use the filters below to find and compare flights from San Francisco to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 2/23

6:15 am-7:18 pm

1 stop10h 03m

Knoxville McGhee Tyson

Fri 2/27

6:51 pm-12:28 am

1 stop8h 37m

$200

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 4/13

6:00 am-3:28 pm

1 stop6h 28m

Knoxville McGhee Tyson

Sun 4/19

4:28 pm-12:22 am

1 stop10h 54m

$221

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 4/6

6:00 am-3:28 pm

1 stop6h 28m

Knoxville McGhee Tyson

Mon 4/13

4:20 pm-12:23 am

1 stop11h 03m

$260

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 4/6

6:00 am-3:28 pm

1 stop6h 28m

Knoxville McGhee Tyson

Fri 4/10

4:20 pm-12:23 am

1 stop11h 03m

$281

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sun 3/8

9:04 pm-3:25 pm

1 stop15h 21m

Knoxville McGhee Tyson

Sun 3/15

6:30 am-7:14 pm

2 stops39h 44m

$306

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 4/6

6:00 am-3:28 pm

1 stop6h 28m

Knoxville McGhee Tyson

Fri 4/10

4:20 pm-12:23 am

1 stop11h 03m

$315

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Tue 4/7

6:29 pm-10:36 am

2 stops13h 07m

Knoxville McGhee Tyson

Mon 4/13

1:43 pm-2:26 pm

1 stop27h 43m

$324

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 2/26

8:48 am-6:06 pm

1 stop30h 18m

Knoxville McGhee Tyson

Mon 3/2

8:13 pm-6:20 pm

2 stops25h 07m

$328

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sun 4/26

11:28 pm-11:18 am

1 stop8h 50m

Knoxville McGhee Tyson

Sat 5/2

3:58 pm-9:28 pm

1 stop8h 30m

$329

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sun 3/8

9:04 pm-3:25 pm

1 stop15h 21m

Knoxville McGhee Tyson

Sun 3/15

6:30 am-7:14 pm

2 stops39h 44m

$330

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from San Francisco to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from San Francisco, with most prices found around $383. If you aren’t able to travel during the month of August, then book flights to Knoxville from San Francisco during July instead. Flights to Knoxville in July, while not as cheap as those in August, still average around $415.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $478 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from San Francisco for as low as $390 on momondo.

How have San Francisco to Knoxville flight prices changed over time?

As of February 2026, prices for San Francisco to Knoxville flights are approximately 39% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Knoxville (SFO to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Knoxville

Fastest flight time

7h 41m

Direct flights

None
The fastest flight from San Francisco to Knoxville takes 7h 41m
There are no direct flights from San Francisco to Knoxville. There are no popular flight routes from San Francisco to Knoxville.
Search flight deals

  • How far is San Francisco to Knoxville McGhee Tyson by plane?

    The straight-line distance from San Francisco to Knoxville McGhee Tyson is 2114.7 mi. In terms of flight time, this usually takes a little over 7h 41m.

  • When did momondo last update prices for flights from San Francisco Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Francisco Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Francisco Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Francisco Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from San Francisco to Knoxville?

  • What is the most popular airline from San Francisco to Knoxville?

Best airlines flying from San Francisco to Knoxville

Compare and see reviews for airlines that fly from San Francisco to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $89Free CancellationRating
5.7
3,051 reviews
Search Frontier flights
DeltaPriceFrom $308Free CancellationRating
7.9
8,174 reviews
Search Delta flights
American AirlinesPriceFrom $308Free CancellationRating
7.2
11,258 reviews
Search American Airlines flights
United AirlinesPriceFrom $328Free CancellationRating
7.4
9,259 reviews
Search United Airlines flights

  • United Airlines Flights From San Francisco to Knoxville

    United Airlines is one of the most popular airlines flying from San Francisco to Knoxville, operating 2 flights/week on average for this route. A good United Airlines flight deal for San Francisco to Knoxville starts from $328 round-trip, up to an average price of $555. Our users have rated United Airlines at 7.4/10.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Francisco to Knoxville for you.

Can I find flights from San Francisco to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for San Francisco to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from San Francisco to Knoxville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from San Francisco to Knoxville.

I’m not ready to book a flight from San Francisco to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Francisco to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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