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Cheap flights from San Francisco to Knoxville from $163

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from San Francisco to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
5:57 pm - 6:42 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
45h 45m2 stops San Diego Phoenix Sky Harbor Intl
Multiple Airlines Logo
7:30 am - 8:49 amTYS  Knoxville McGhee Tyson-SFO San Francisco
28h 19m1 stop Las Vegas Harry Reid Intl
$225Multiple Airlines
Tue, Jan 19 - Mon, Feb 8
Multiple Airlines Logo
6:30 pm - 8:25 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
22h 55m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
12:57 pm - 9:16 amTYS  Knoxville McGhee Tyson-SFO San Francisco
23h 19m2 stops Orlando Sanford Intl Dallas/Fort Worth
$310Multiple Airlines
Thu, Dec 3 - Thu, Dec 10
American Airlines Logo
12:49 pm - 11:40 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
7h 51m1 stop Dallas/Fort Worth
American Airlines Logo
6:02 pm - 11:09 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
8h 07m1 stop Charlotte Douglas
$325American Airlines
Thu, Dec 3 - Thu, Dec 10
American Airlines Logo
5:00 am - 3:21 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
7h 21m1 stop Charlotte Douglas
American Airlines Logo
10:20 am - 4:59 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
9h 39m1 stop Charlotte Douglas
$325American Airlines
Tue, Dec 1 - Wed, Dec 9
Delta Logo
9:59 pm - 10:01 amSFO  San Francisco-TYS Knoxville McGhee Tyson
9h 02m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:40 am - 1:24 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
10h 44m2 stops Atlanta Hartsfield-Jackson Seattle/Tacoma Intl
$373Delta
Tue, Dec 1 - Wed, Dec 9
Delta Logo
11:59 pm - 10:01 amSFO  San Francisco-TYS Knoxville McGhee Tyson
7h 02m1 stop Atlanta Hartsfield-Jackson
Delta Logo
12:32 pm - 6:56 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
9h 24m1 stop Atlanta Hartsfield-Jackson
$377Delta
Mon, Dec 7 - Thu, Dec 10
United Airlines Logo
12:45 am - 11:12 amSFO  San Francisco-TYS Knoxville McGhee Tyson
7h 27m1 stop Houston George Bush Intcntl
United Airlines Logo
4:43 pm - 9:23 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
7h 40m1 stop Denver Intl
$377United Airlines
Sun, Dec 6 - Mon, Dec 14
United Airlines Logo
12:45 am - 11:12 amSFO  San Francisco-TYS Knoxville McGhee Tyson
7h 27m1 stop Houston George Bush Intcntl
United Airlines Logo
7:35 pm - 1:30 amTYS  Knoxville McGhee Tyson-SFO San Francisco
8h 55m1 stop Washington, D.C. Dulles Intl
$377United Airlines
Sun, Dec 13 - Mon, Dec 21
Southwest Logo
6:20 am - 4:10 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
6h 50m1 stop Denver Intl
Southwest Logo
7:10 am - 2:40 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
10h 30m2 stops Nashville Intl Denver Intl
$382Southwest
Sat, Dec 5 - Sat, Dec 12
Southwest Logo
5:05 am - 7:50 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
11h 45m2 stops Phoenix Sky Harbor Intl Nashville Intl
Southwest Logo
7:55 am - 1:50 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
8h 55m1 stop Baltimore/Washington
$382Southwest
Wed, Dec 2 - Wed, Dec 9

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American Airlines flights from San Francisco to Knoxville

Our best American Airlines deals on San Francisco to Knoxville flight tickets
American Airlines
Dec 1
SFO5:00 amSan Francisco
7h 21m
1 stop
TYS3:21 pmKnoxville McGhee Tyson
Dec 9
TYS10:20 amKnoxville McGhee Tyson
9h 39m
1 stop
SFO4:59 pmSan Francisco
$325
American Airlines
Dec 1
SFO5:00 amSan Francisco
8h 36m
1 stop
TYS4:36 pmKnoxville McGhee Tyson
Dec 5
TYS5:30 amKnoxville McGhee Tyson
7h 52m
1 stop
SFO10:22 amSan Francisco
$377
American Airlines
Nov 17
SFO5:00 amSan Francisco
7h 23m
1 stop
TYS3:23 pmKnoxville McGhee Tyson
Nov 18
TYS6:50 amKnoxville McGhee Tyson
9h 17m
1 stop
SFO1:07 pmSan Francisco
$403

Delta flights from San Francisco to Knoxville

Our best Delta deals on San Francisco to Knoxville flight tickets
Delta
Dec 1
SFO9:59 pmSan Francisco
9h 02m
1 stop
TYS10:01 amKnoxville McGhee Tyson
Dec 9
TYS5:40 amKnoxville McGhee Tyson
10h 44m
2 stops
SFO1:24 pmSan Francisco
$373
Delta
Nov 23
SFO6:00 amSan Francisco
8h 49m
1 stop
TYS5:49 pmKnoxville McGhee Tyson
Dec 2
TYS12:32 pmKnoxville McGhee Tyson
9h 29m
1 stop
SFO7:01 pmSan Francisco
$398
Delta
Apr 6
SFO10:30 pmSan Francisco
9h 36m
1 stop
TYS11:06 amKnoxville McGhee Tyson
Apr 10
TYS2:25 pmKnoxville McGhee Tyson
10h 10m
1 stop
SFO9:35 pmSan Francisco
$403

momondo Fare Finder

 
Use the filters below to find and compare flights from San Francisco to Knoxville that are best for you.

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Route

Depart

Return

Price

Cheapest round-trip

San FranciscoKnoxville

SFO San Francisco - TYS Knoxville McGhee Tyson

SFOTYS

San Francisco

Tue 1/19

5:57 pm-6:42 pm

2 stops45h 45m

Knoxville McGhee Tyson

Mon 2/8

7:30 am-8:49 am

1 stop28h 19m

$225

San FranciscoKnoxville

SFO San Francisco - TYS Knoxville McGhee Tyson

SFOTYS

San Francisco

Thu 12/3

6:30 pm-8:25 pm

1 stop22h 55m

Knoxville McGhee Tyson

Thu 12/10

12:57 pm-9:16 am

2 stops23h 19m

$310

San FranciscoKnoxville

SFO San Francisco - TYS Knoxville McGhee Tyson

SFOTYS

San Francisco

Thu 12/3

12:49 pm-11:40 pm

1 stop7h 51m

Knoxville McGhee Tyson

Thu 12/10

6:02 pm-11:09 pm

1 stop8h 07m

$325

San FranciscoKnoxville

SFO San Francisco - TYS Knoxville McGhee Tyson

SFOTYS

San Francisco

Tue 12/1

5:00 am-3:21 pm

1 stop7h 21m

Knoxville McGhee Tyson

Wed 12/9

10:20 am-4:59 pm

1 stop9h 39m

$325

San FranciscoKnoxville

SFO San Francisco - TYS Knoxville McGhee Tyson

SFOTYS

San Francisco

Tue 12/1

9:59 pm-10:01 am

1 stop9h 02m

Knoxville McGhee Tyson

Wed 12/9

5:40 am-1:24 pm

2 stops10h 44m

$373

San FranciscoKnoxville

SFO San Francisco - TYS Knoxville McGhee Tyson

SFOTYS

San Francisco

Mon 12/7

11:59 pm-10:01 am

1 stop7h 02m

Knoxville McGhee Tyson

Thu 12/10

12:32 pm-6:56 pm

1 stop9h 24m

$377
Quickest round-trip

San FranciscoKnoxville

SFO San Francisco - TYS Knoxville McGhee Tyson

SFOTYS

San Francisco

Sun 12/6

12:45 am-11:12 am

1 stop7h 27m

Knoxville McGhee Tyson

Mon 12/14

4:43 pm-9:23 pm

1 stop7h 40m

$377

San FranciscoKnoxville

SFO San Francisco - TYS Knoxville McGhee Tyson

SFOTYS

San Francisco

Sun 12/13

12:45 am-11:12 am

1 stop7h 27m

Knoxville McGhee Tyson

Mon 12/21

7:35 pm-1:30 am

1 stop8h 55m

$377

San FranciscoKnoxville

SFO San Francisco - TYS Knoxville McGhee Tyson

SFOTYS

San Francisco

Sat 12/5

6:20 am-4:10 pm

1 stop6h 50m

Knoxville McGhee Tyson

Sat 12/12

7:10 am-2:40 pm

2 stops10h 30m

$382

San FranciscoKnoxville

SFO San Francisco - TYS Knoxville McGhee Tyson

SFOTYS

San Francisco

Wed 12/2

5:05 am-7:50 pm

2 stops11h 45m

Knoxville McGhee Tyson

Wed 12/9

7:55 am-1:50 pm

1 stop8h 55m

$382

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from San Francisco to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Francisco and Knoxville?

Prices are currently low for flights on this route.

Typical prices usually range from $498 to $848.
The lowest price recently found on this route was $225.

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from San Francisco, with most prices found around $386. If you aren’t able to travel during the month of January, then book flights to Knoxville from San Francisco during October instead. Flights to Knoxville in October, while not as cheap as those in January, still average around $405.

How far in advance should I book a flight from San Francisco to Knoxville?

You are more likely to see cheaper flights to Knoxville from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $499 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from San Francisco for as low as $334 on momondo.

How have San Francisco to Knoxville flight prices changed over time?

As of November 2026, prices for San Francisco to Knoxville flights are approximately 107% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Knoxville (SFO to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Knoxville

Best Price Found

$163

Fastest flight time

6h 21m

Direct flights

None
The best one-way flight to Knoxville from San Francisco in the past 72 hours is $163. The best round-trip flight deal from San Francisco to Knoxville found on momondo in the last 72 hours is $225.
The fastest flight from San Francisco to Knoxville takes 6h 21m
There are no direct flights from San Francisco to Knoxville. There are no popular flight routes from San Francisco to Knoxville.
Search flight deals

Frequently asked questions about flying from San Francisco to Knoxville

  • How far is San Francisco to Knoxville McGhee Tyson by plane?

    The straight-line distance from San Francisco to Knoxville McGhee Tyson is 2114.2 mi. In terms of flight time, this usually takes a little over 6h 21m.

  • When did momondo last update prices for flights from San Francisco Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Francisco Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Francisco Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Francisco Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from San Francisco to Knoxville?

Best airlines flying from San Francisco to Knoxville

Compare and see reviews for airlines that fly from San Francisco to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $220Free CancellationRating
5.5
2,512 reviews
Search Frontier flights
SouthwestPriceFrom $238Free CancellationRating
8.0
4,215 reviews
Search Southwest flights
DeltaPriceFrom $295Free CancellationRating
7.8
8,699 reviews
Search Delta flights
United AirlinesPriceFrom $328Free CancellationRating
7.3
10,460 reviews
Search United Airlines flights
American AirlinesPriceFrom $328Free CancellationRating
7.0
12,228 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Kodak
Oak Ridge
Lenoir City
Newport
Dandridge
Clinton
Rockford
Jefferson City

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Francisco to Knoxville for you.

Can I find flights from San Francisco to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for San Francisco to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from San Francisco to Knoxville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from San Francisco to Knoxville.

I’m not ready to book a flight from San Francisco to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Francisco to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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