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Cheap flights from San Francisco to Knoxville from $129

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Knoxville departing on 8/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from San Francisco to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
6:00 am - 7:24 pm
SFO
-
TYS
10h 24m
1 stop
Frontier Logo
8:19 pm - 12:18 am
TYS
-
SFO
6h 59m
1 stop
$244Frontier
Wed, Aug 5 - Wed, Aug 12
Delta Logo
10:00 pm - 9:36 am
SFO
-
TYS
8h 36m
1 stop
Delta Logo
6:12 pm - 11:58 pm
TYS
-
SFO
8h 46m
1 stop
$257Delta
Thu, Aug 6 - Tue, Aug 11
Frontier Logo
7:04 pm - 7:24 pm
SFO
-
TYS
21h 20m
1 stop
Frontier Logo
8:19 pm - 3:46 pm
TYS
-
SFO
22h 27m
1 stop
$271Frontier
Thu, Aug 6 - Wed, Aug 12
Southwest Logo
6:35 am - 4:30 pm
SFO
-
TYS
6h 55m
1 stop
Southwest Logo
5:45 pm - 9:55 pm
TYS
-
SFO
7h 10m
1 stop
$272Southwest
Wed, Aug 26 - Thu, Aug 27
Southwest Logo
6:35 am - 4:30 pm
SFO
-
TYS
6h 55m
1 stop
Southwest Logo
7:10 am - 2:40 pm
TYS
-
SFO
10h 30m
2 stops
$278Southwest
Wed, Aug 26 - Thu, Aug 27
American Airlines Logo
12:38 pm - 11:18 pm
SFO
-
TYS
7h 40m
1 stop
American Airlines Logo
6:05 pm - 10:40 pm
TYS
-
SFO
7h 35m
1 stop
$282American Airlines
Fri, Aug 14 - Mon, Aug 17
Multiple Airlines Logo
11:00 am - 9:46 pm
SFO
-
TYS
7h 46m
1 stop
Multiple Airlines Logo
8:30 am - 6:45 pm
TYS
-
SFO
37h 15m
2 stops
$285Multiple Airlines
Mon, Aug 24 - Fri, Aug 28
Delta Logo
6:00 am - 3:30 pm
SFO
-
TYS
6h 30m
1 stop
Delta Logo
10:28 am - 2:47 pm
TYS
-
SFO
7h 19m
1 stop
$286Delta
Mon, Aug 24 - Fri, Aug 28
Frontier Logo
6:00 am - 7:24 pm
SFO
-
TYS
10h 24m
1 stop
Frontier Logo
8:19 pm - 12:18 am
TYS
-
SFO
6h 59m
1 stop
$297Frontier
Wed, Jul 29 - Wed, Aug 5
Frontier Logo
6:00 am - 7:24 pm
SFO
-
TYS
10h 24m
1 stop
Frontier Logo
8:19 pm - 12:18 am
TYS
-
SFO
6h 59m
1 stop
$298Frontier
Mon, Aug 3 - Fri, Aug 7

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American Airlines flights from San Francisco to Knoxville

Our best American Airlines deals on San Francisco to Knoxville flight tickets
American Airlines
Aug 14
SFO12:38 pmSan Francisco
7h 40m
1 stop
TYS11:18 pmKnoxville McGhee Tyson
Aug 17
TYS6:05 pmKnoxville McGhee Tyson
7h 35m
1 stop
SFO10:40 pmSan Francisco
$282
American Airlines
Aug 4
SFO11:20 pmSan Francisco
8h 58m
1 stop
TYS11:18 amKnoxville McGhee Tyson
Aug 11
TYS5:15 amKnoxville McGhee Tyson
9h 13m
1 stop
SFO11:28 amSan Francisco
$304
American Airlines
Jul 22
SFO10:05 pmSan Francisco
7h 26m
1 stop
TYS8:31 amKnoxville McGhee Tyson
Aug 4
TYS5:31 pmKnoxville McGhee Tyson
7h 57m
1 stop
SFO10:28 pmSan Francisco
$464

Delta flights from San Francisco to Knoxville

Our best Delta deals on San Francisco to Knoxville flight tickets
Delta
Aug 6
SFO10:00 pmSan Francisco
8h 36m
1 stop
TYS9:36 amKnoxville McGhee Tyson
Aug 11
TYS6:12 pmKnoxville McGhee Tyson
8h 46m
1 stop
SFO11:58 pmSan Francisco
$257
Delta
Aug 24
SFO6:00 amSan Francisco
6h 30m
1 stop
TYS3:30 pmKnoxville McGhee Tyson
Aug 28
TYS10:28 amKnoxville McGhee Tyson
7h 19m
1 stop
SFO2:47 pmSan Francisco
$286
Delta
Sep 29
SFO11:35 pmSan Francisco
6h 54m
1 stop
TYS9:29 amKnoxville McGhee Tyson
Oct 6
TYS11:45 amKnoxville McGhee Tyson
9h 35m
1 stop
SFO6:20 pmSan Francisco
$379

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 8, 2026.
Use the filters below to find and compare flights from San Francisco to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Wed 8/5

6:00 am-7:24 pm

1 stop10h 24m

Knoxville McGhee Tyson

Wed 8/12

8:19 pm-12:18 am

1 stop6h 59m

$244

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 8/6

10:00 pm-9:36 am

1 stop8h 36m

Knoxville McGhee Tyson

Tue 8/11

6:12 pm-11:58 pm

1 stop8h 46m

$257

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 8/6

7:04 pm-7:24 pm

1 stop21h 20m

Knoxville McGhee Tyson

Wed 8/12

8:19 pm-3:46 pm

1 stop22h 27m

$271

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Wed 8/26

6:35 am-4:30 pm

1 stop6h 55m

Knoxville McGhee Tyson

Thu 8/27

5:45 pm-9:55 pm

1 stop7h 10m

$272

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Wed 8/26

6:35 am-4:30 pm

1 stop6h 55m

Knoxville McGhee Tyson

Thu 8/27

7:10 am-2:40 pm

2 stops10h 30m

$278

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Fri 8/14

12:38 pm-11:18 pm

1 stop7h 40m

Knoxville McGhee Tyson

Mon 8/17

6:05 pm-10:40 pm

1 stop7h 35m

$282

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 8/24

11:00 am-9:46 pm

1 stop7h 46m

Knoxville McGhee Tyson

Fri 8/28

8:30 am-6:45 pm

2 stops37h 15m

$285
Quickest round-trip

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 8/24

6:00 am-3:30 pm

1 stop6h 30m

Knoxville McGhee Tyson

Fri 8/28

10:28 am-2:47 pm

1 stop7h 19m

$286

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Wed 7/29

6:00 am-7:24 pm

1 stop10h 24m

Knoxville McGhee Tyson

Wed 8/5

8:19 pm-12:18 am

1 stop6h 59m

$297

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 8/3

6:00 am-7:24 pm

1 stop10h 24m

Knoxville McGhee Tyson

Fri 8/7

8:19 pm-12:18 am

1 stop6h 59m

$298

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from San Francisco to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Francisco and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of February is, on average, the cheapest month to fly to Knoxville from San Francisco, with most prices found around $409. If you aren’t able to travel during the month of February, then book flights to Knoxville from San Francisco during August instead. Flights to Knoxville in August, while not as cheap as those in February, still average around $423.

How far in advance should I book a flight from San Francisco to Knoxville?

You are more likely to see cheaper flights to Knoxville from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $493 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from San Francisco for as low as $334 on momondo.

How have San Francisco to Knoxville flight prices changed over time?

As of July 2026, prices for San Francisco to Knoxville flights are approximately 19% cheaper when compared to flights at the same time last year.

When to book flights from San Francisco to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Knoxville (SFO to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Knoxville

Fastest flight time

6h 37m

Direct flights

None
The fastest flight from San Francisco to Knoxville takes 6h 37m
There are no direct flights from San Francisco to Knoxville. There are no popular flight routes from San Francisco to Knoxville.
Search flight deals

Frequently asked questions about flying from San Francisco to Knoxville

  • How far is San Francisco to Knoxville McGhee Tyson by plane?

    The straight-line distance from San Francisco to Knoxville McGhee Tyson is 2114.2 mi. In terms of flight time, this usually takes a little over 6h 37m.

  • When did momondo last update prices for flights from San Francisco Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Francisco Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Francisco Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Francisco Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from San Francisco to Knoxville?

  • What is the most popular airline from San Francisco to Knoxville?

Best airlines flying from San Francisco to Knoxville

Compare and see reviews for airlines that fly from San Francisco to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $89Free CancellationRating
5.6
2,835 reviews
Search Frontier flights
American AirlinesPriceFrom $308Free CancellationRating
7.1
11,783 reviews
Search American Airlines flights
DeltaPriceFrom $308Free CancellationRating
7.8
8,451 reviews
Search Delta flights
United AirlinesPriceFrom $328Free CancellationRating
7.4
9,945 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Murphy
Crossville
Oak Ridge
Kodak
Newport
Lenoir City
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Francisco to Knoxville for you.

Can I find flights from San Francisco to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for San Francisco to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from San Francisco to Knoxville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from San Francisco to Knoxville.

I’m not ready to book a flight from San Francisco to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Francisco to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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