Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from San Francisco to Knoxville from $131

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Knoxville departing on 7/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from San Francisco to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
6:00 am - 7:36 pm
SFO
-
TYS
10h 36m
1 stop
Frontier Logo
8:32 pm - 11:36 am
TYS
-
SFO
18h 04m
1 stop
$302Frontier
Mon, Jul 27 - Mon, Aug 3
Multiple Airlines Logo
11:42 am - 3:58 pm
SFO
-
TYS
25h 16m
1 stop
Multiple Airlines Logo
6:30 am - 1:17 pm
TYS
-
SFO
9h 47m
1 stop
$313Multiple Airlines
Thu, Sep 24 - Mon, Sep 28
Multiple Airlines Logo
9:00 pm - 3:58 pm
SFO
-
TYS
15h 58m
1 stop
Multiple Airlines Logo
6:30 am - 1:17 pm
TYS
-
SFO
9h 47m
1 stop
$316Multiple Airlines
Thu, Sep 24 - Mon, Sep 28
Multiple Airlines Logo
7:11 pm - 10:24 pm
SFO
-
TYS
24h 13m
2 stops
Multiple Airlines Logo
2:47 pm - 10:25 am
TYS
-
SFO
22h 38m
1 stop
$323Multiple Airlines
Wed, Jul 15 - Mon, Aug 10
Multiple Airlines Logo
4:51 pm - 3:58 pm
SFO
-
TYS
20h 07m
1 stop
Multiple Airlines Logo
6:30 am - 9:18 pm
TYS
-
SFO
17h 48m
2 stops
$327Multiple Airlines
Thu, Sep 24 - Mon, Sep 28
Frontier Logo
6:00 am - 3:29 pm
SFO
-
TYS
6h 29m
1 stop
Frontier Logo
4:27 pm - 12:15 am
TYS
-
SFO
10h 48m
1 stop
$335Frontier
Thu, Oct 8 - Sun, Oct 11
Multiple Airlines Logo
3:11 pm - 9:46 pm
SFO
-
TYS
27h 35m
1 stop
Multiple Airlines Logo
10:30 am - 10:57 pm
TYS
-
SFO
15h 27m
2 stops
$338Multiple Airlines
Thu, Aug 20 - Tue, Aug 25
Frontier Logo
6:00 am - 7:36 pm
SFO
-
TYS
10h 36m
1 stop
Frontier Logo
8:32 pm - 8:54 pm
TYS
-
SFO
27h 22m
1 stop
$344Frontier
Mon, Aug 3 - Wed, Aug 5
Frontier Logo
6:00 am - 7:36 pm
SFO
-
TYS
10h 36m
1 stop
Frontier Logo
8:32 pm - 11:36 am
TYS
-
SFO
18h 04m
1 stop
$348Frontier
Wed, Jul 15 - Mon, Aug 10
Multiple Airlines Logo
11:42 am - 5:18 pm
SFO
-
TYS
26h 36m
1 stop
Multiple Airlines Logo
6:30 am - 11:45 pm
TYS
-
SFO
20h 15m
1 stop
$350Multiple Airlines
Wed, Sep 23 - Mon, Sep 28

Frontier flights from San Francisco to Knoxville

Our best Frontier deals on San Francisco to Knoxville flight tickets
Frontier
Jul 27
SFO6:00 amSan Francisco
10h 36m
1 stop
TYS7:36 pmKnoxville McGhee Tyson
Aug 3
TYS8:32 pmKnoxville McGhee Tyson
18h 04m
1 stop
SFO11:36 amSan Francisco
$302
Frontier
Oct 8
SFO6:00 amSan Francisco
6h 29m
1 stop
TYS3:29 pmKnoxville McGhee Tyson
Oct 11
TYS4:27 pmKnoxville McGhee Tyson
10h 48m
1 stop
SFO12:15 amSan Francisco
$335
Frontier
Aug 3
SFO6:00 amSan Francisco
10h 36m
1 stop
TYS7:36 pmKnoxville McGhee Tyson
Aug 5
TYS8:32 pmKnoxville McGhee Tyson
27h 22m
1 stop
SFO8:54 pmSan Francisco
$344

Delta flights from San Francisco to Knoxville

Our best Delta deals on San Francisco to Knoxville flight tickets
Delta
Jul 6
SFO11:59 pmSan Francisco
8h 06m
1 stop
TYS11:05 amKnoxville McGhee Tyson
Jul 9
TYS7:15 amKnoxville McGhee Tyson
10h 02m
1 stop
SFO2:17 pmSan Francisco
$389
Delta
Jun 6
SFO10:25 pmSan Francisco
9h 02m
1 stop
TYS10:27 amKnoxville McGhee Tyson
Jun 11
TYS3:54 pmKnoxville McGhee Tyson
8h 55m
1 stop
SFO9:49 pmSan Francisco
$414
Delta
Jun 1
SFO10:55 pmSan Francisco
7h 39m
1 stop
TYS9:34 amKnoxville McGhee Tyson
Jun 8
TYS6:42 pmKnoxville McGhee Tyson
8h 11m
1 stop
SFO11:53 pmSan Francisco
$429

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 15, 2026.
Use the filters below to find and compare flights from San Francisco to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 7/27

6:00 am-7:36 pm

1 stop10h 36m

Knoxville McGhee Tyson

Mon 8/3

8:32 pm-11:36 am

1 stop18h 04m

$302

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 9/24

11:42 am-3:58 pm

1 stop25h 16m

Knoxville McGhee Tyson

Mon 9/28

6:30 am-1:17 pm

1 stop9h 47m

$313

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 9/24

9:00 pm-3:58 pm

1 stop15h 58m

Knoxville McGhee Tyson

Mon 9/28

6:30 am-1:17 pm

1 stop9h 47m

$316

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Wed 7/15

7:11 pm-10:24 pm

2 stops24h 13m

Knoxville McGhee Tyson

Mon 8/10

2:47 pm-10:25 am

1 stop22h 38m

$323

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 9/24

4:51 pm-3:58 pm

1 stop20h 07m

Knoxville McGhee Tyson

Mon 9/28

6:30 am-9:18 pm

2 stops17h 48m

$327
Quickest round-trip

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 10/8

6:00 am-3:29 pm

1 stop6h 29m

Knoxville McGhee Tyson

Sun 10/11

4:27 pm-12:15 am

1 stop10h 48m

$335

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 8/20

3:11 pm-9:46 pm

1 stop27h 35m

Knoxville McGhee Tyson

Tue 8/25

10:30 am-10:57 pm

2 stops15h 27m

$338

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 8/3

6:00 am-7:36 pm

1 stop10h 36m

Knoxville McGhee Tyson

Wed 8/5

8:32 pm-8:54 pm

1 stop27h 22m

$344

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Wed 7/15

6:00 am-7:36 pm

1 stop10h 36m

Knoxville McGhee Tyson

Mon 8/10

8:32 pm-11:36 am

1 stop18h 04m

$348

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Wed 9/23

11:42 am-5:18 pm

1 stop26h 36m

Knoxville McGhee Tyson

Mon 9/28

6:30 am-11:45 pm

1 stop20h 15m

$350

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Knoxville from

How to get the cheapest flight ticket from San Francisco to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Francisco and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from San Francisco, with most prices found around $396. If you aren’t able to travel during the month of August, then book flights to Knoxville from San Francisco during July instead. Flights to Knoxville in July, while not as cheap as those in August, still average around $396.

How far in advance should I book a flight from San Francisco to Knoxville?

You are more likely to see cheaper flights to Knoxville from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $480 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from San Francisco for as low as $334 on momondo.

How have San Francisco to Knoxville flight prices changed over time?

As of May 2026, prices for San Francisco to Knoxville flights are approximately 14% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Knoxville (SFO to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Knoxville

Fastest flight time

6h 26m

Direct flights

None
The fastest flight from San Francisco to Knoxville takes 6h 26m
There are no direct flights from San Francisco to Knoxville. There are no popular flight routes from San Francisco to Knoxville.
Search flight deals

Frequently asked questions about flying from San Francisco to Knoxville

  • How far is San Francisco to Knoxville McGhee Tyson by plane?

    The straight-line distance from San Francisco to Knoxville McGhee Tyson is 2114.2 mi. In terms of flight time, this usually takes a little over 6h 26m.

  • When did momondo last update prices for flights from San Francisco Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Francisco Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Francisco Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Francisco Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from San Francisco to Knoxville?

  • What is the most popular airline from San Francisco to Knoxville?

Best airlines flying from San Francisco to Knoxville

Compare and see reviews for airlines that fly from San Francisco to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $89Free CancellationRating
5.6
2,951 reviews
Search Frontier flights
DeltaPriceFrom $308Free CancellationRating
7.9
8,453 reviews
Search Delta flights
American AirlinesPriceFrom $308Free CancellationRating
7.1
11,662 reviews
Search American Airlines flights
United AirlinesPriceFrom $328Free CancellationRating
7.4
9,720 reviews
Search United Airlines flights

  • United Airlines Flights From San Francisco to Knoxville

    United Airlines is one of the most popular airlines flying from San Francisco to Knoxville, operating 3 flights/week on average for this route. A good United Airlines flight deal for San Francisco to Knoxville starts from $328 round-trip, up to an average price of $525. Our users have rated United Airlines at 7.4/10.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Crossville
Maryville
Murphy
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Francisco to Knoxville for you.

Can I find flights from San Francisco to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for San Francisco to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from San Francisco to Knoxville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from San Francisco to Knoxville.

I’m not ready to book a flight from San Francisco to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Francisco to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your Knoxville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sun 6/14
Sun 6/21
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States