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Cheap flights from San Francisco to Knoxville from $91

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Knoxville departing on 1/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Francisco to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
6:05 am - 3:28 pm
SFO
-
TYS
6h 23m1 stop
Frontier Logo
8:18 pm - 11:00 am
TYS
-
SFO
17h 42m1 stop
$183Frontier
Thu, Jan 8 - Thu, Jan 15
Frontier Logo
6:15 am - 3:35 pm
SFO
-
TYS
6h 20m1 stop
Frontier Logo
4:25 pm - 12:28 am
TYS
-
SFO
11h 03m1 stop
$217Frontier
Mon, Jan 26 - Fri, Jan 30
Multiple Airlines Logo
10:58 pm - 10:34 am
SFO
-
TYS
32h 36m2 stops
Multiple Airlines Logo
8:30 am - 5:58 pm
TYS
-
SFO
12h 28m1 stop
$228Multiple Airlines
Sat, Feb 21 - Thu, Feb 26
Multiple Airlines Logo
10:18 pm - 4:50 pm
SFO
-
TYS
15h 32m1 stop
Multiple Airlines Logo
8:18 pm - 11:00 am
TYS
-
SFO
17h 42m1 stop
$245Multiple Airlines
Thu, Jan 8 - Thu, Jan 15
Multiple Airlines Logo
2:13 pm - 4:50 pm
SFO
-
TYS
23h 37m1 stop
Multiple Airlines Logo
8:18 pm - 11:26 am
TYS
-
SFO
18h 08m2 stops
$281Multiple Airlines
Thu, Jan 8 - Thu, Jan 15
Multiple Airlines Logo
7:08 pm - 5:22 pm
SFO
-
TYS
19h 14m1 stop
Multiple Airlines Logo
8:30 am - 5:58 pm
TYS
-
SFO
12h 28m1 stop
$283Multiple Airlines
Sat, Feb 21 - Thu, Feb 26
Frontier Logo
6:24 am - 3:31 pm
SFO
-
TYS
6h 07m1 stop
Frontier Logo
4:46 pm - 12:24 am
TYS
-
SFO
10h 38m1 stop
$284Frontier
Thu, Jan 1 - Mon, Jan 5
Multiple Airlines Logo
7:08 pm - 5:22 pm
SFO
-
TYS
19h 14m1 stop
Multiple Airlines Logo
3:50 pm - 7:48 am
TYS
-
SFO
18h 58m2 stops
$319Multiple Airlines
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
7:00 am - 5:42 pm
SFO
-
TYS
7h 42m1 stop
American Airlines Logo
12:21 pm - 5:24 pm
TYS
-
SFO
8h 03m1 stop
$329American Airlines
Wed, Feb 4 - Sun, Feb 8
American Airlines Logo
9:10 am - 10:47 pm
SFO
-
TYS
10h 37m2 stops
American Airlines Logo
4:00 pm - 10:28 pm
TYS
-
SFO
9h 28m1 stop
$334American Airlines
Wed, Feb 4 - Sun, Feb 8

Frontier flights from San Francisco to Knoxville

Our best Frontier deals on San Francisco to Knoxville flight tickets
Frontier
Jan 8
SFO6:05 amSan Francisco
6h 23m
1 stop
TYS3:28 pmKnoxville McGhee Tyson
Jan 15
TYS8:18 pmKnoxville McGhee Tyson
17h 42m
1 stop
SFO11:00 amSan Francisco
$183
Find similar
Frontier
Jan 26
SFO6:15 amSan Francisco
6h 20m
1 stop
TYS3:35 pmKnoxville McGhee Tyson
Jan 30
TYS4:25 pmKnoxville McGhee Tyson
11h 03m
1 stop
SFO12:28 amSan Francisco
$217
Find similar
Frontier
Jan 1
SFO6:24 amSan Francisco
6h 07m
1 stop
TYS3:31 pmKnoxville McGhee Tyson
Jan 5
TYS4:46 pmKnoxville McGhee Tyson
10h 38m
1 stop
SFO12:24 amSan Francisco
$284
Find similar

American Airlines flights from San Francisco to Knoxville

Our best American Airlines deals on San Francisco to Knoxville flight tickets
American Airlines
Feb 4
SFO7:00 amSan Francisco
7h 42m
1 stop
TYS5:42 pmKnoxville McGhee Tyson
Feb 8
TYS12:21 pmKnoxville McGhee Tyson
8h 03m
1 stop
SFO5:24 pmSan Francisco
$329
Find similar
American Airlines
Feb 4
SFO9:10 amSan Francisco
10h 37m
2 stops
TYS10:47 pmKnoxville McGhee Tyson
Feb 8
TYS4:00 pmKnoxville McGhee Tyson
9h 28m
1 stop
SFO10:28 pmSan Francisco
$334
Find similar
American Airlines
Jan 12
SFO9:10 amSan Francisco
10h 37m
2 stops
TYS10:47 pmKnoxville McGhee Tyson
Jan 15
TYS6:51 pmKnoxville McGhee Tyson
7h 21m
1 stop
SFO11:12 pmSan Francisco
$390
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from San Francisco to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 1/8

6:05 am-3:28 pm

1 stop6h 23m

Knoxville McGhee Tyson

Thu 1/15

8:18 pm-11:00 am

1 stop17h 42m

$183

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 1/26

6:15 am-3:35 pm

1 stop6h 20m

Knoxville McGhee Tyson

Fri 1/30

4:25 pm-12:28 am

1 stop11h 03m

$217

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sat 2/21

10:58 pm-10:34 am

2 stops32h 36m

Knoxville McGhee Tyson

Thu 2/26

8:30 am-5:58 pm

1 stop12h 28m

$228

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 1/8

10:18 pm-4:50 pm

1 stop15h 32m

Knoxville McGhee Tyson

Thu 1/15

8:18 pm-11:00 am

1 stop17h 42m

$245

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 1/8

2:13 pm-4:50 pm

1 stop23h 37m

Knoxville McGhee Tyson

Thu 1/15

8:18 pm-11:26 am

2 stops18h 08m

$281

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sat 2/21

7:08 pm-5:22 pm

1 stop19h 14m

Knoxville McGhee Tyson

Thu 2/26

8:30 am-5:58 pm

1 stop12h 28m

$283

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 1/1

6:24 am-3:31 pm

1 stop6h 07m

Knoxville McGhee Tyson

Mon 1/5

4:46 pm-12:24 am

1 stop10h 38m

$284

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sat 2/21

7:08 pm-5:22 pm

1 stop19h 14m

Knoxville McGhee Tyson

Wed 2/25

3:50 pm-7:48 am

2 stops18h 58m

$319

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Wed 2/4

7:00 am-5:42 pm

1 stop7h 42m

Knoxville McGhee Tyson

Sun 2/8

12:21 pm-5:24 pm

1 stop8h 03m

$329

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Wed 2/4

9:10 am-10:47 pm

2 stops10h 37m

Knoxville McGhee Tyson

Sun 2/8

4:00 pm-10:28 pm

1 stop9h 28m

$334

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from San Francisco to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from San Francisco, with most prices found around $383. If you aren’t able to travel during the month of August, then book flights to Knoxville from San Francisco during July instead. Flights to Knoxville in July, while not as cheap as those in August, still average around $397.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from San Francisco to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $425. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from San Francisco to Knoxville for around $555.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from San Francisco to Knoxville when you can find flight prices for as low as $453. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $514.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $483 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from San Francisco for as low as $372 on momondo.

How have San Francisco to Knoxville flight prices changed over time?

As of December 2025, prices for San Francisco to Knoxville flights are approximately 8% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Knoxville (SFO to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Knoxville

Fastest flight time

6h 21m

Direct flights

None
The fastest flight from San Francisco to Knoxville takes 6h 21m
There are no direct flights from San Francisco to Knoxville. There are no popular flight routes from San Francisco to Knoxville.
Search flight deals

  • How far is San Francisco to Knoxville McGhee Tyson by plane?

    The straight-line distance from San Francisco to Knoxville McGhee Tyson is 2114.7 mi. In terms of flight time, this usually takes a little over 6h 21m.

  • When did momondo last update prices for flights from San Francisco Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Francisco Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Francisco Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Francisco Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from San Francisco to Knoxville?

  • What is the most popular airline from San Francisco to Knoxville?

Best airlines flying from San Francisco to Knoxville

Compare and see reviews for airlines that fly from San Francisco to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $149Free CancellationRating
5.8
3,081 reviews
Search Frontier flights
DeltaPriceFrom $308Free CancellationRating
7.9
8,005 reviews
Search Delta flights
American AirlinesPriceFrom $308Free CancellationRating
7.2
11,055 reviews
Search American Airlines flights
United AirlinesPriceFrom $328Free CancellationRating
7.4
9,092 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Murphy
Alcoa
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Francisco to Knoxville for you.

Can I find flights from San Francisco to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for San Francisco to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from San Francisco to Knoxville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from San Francisco to Knoxville.

I’m not ready to book a flight from San Francisco to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Francisco to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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