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Cheap flights from San Francisco to Knoxville from $128

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Knoxville departing on 5/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Francisco to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
9:00 pm - 3:28 pm
SFO
-
TYS
15h 28m
1 stop
Frontier Logo
4:28 pm - 9:13 am
TYS
-
SFO
19h 45m
1 stop
$226Frontier
Sun, Apr 12 - Sun, Apr 19
Frontier Logo
9:00 pm - 3:28 pm
SFO
-
TYS
15h 28m
1 stop
Frontier Logo
4:28 pm - 9:13 am
TYS
-
SFO
19h 45m
1 stop
$242Frontier
Sun, Apr 12 - Thu, Apr 16
Frontier Logo
12:52 pm - 7:33 pm
SFO
-
TYS
27h 41m
1 stop
Frontier Logo
8:32 pm - 11:42 am
TYS
-
SFO
18h 10m
1 stop
$246Frontier
Sun, May 24 - Mon, Jun 1
Frontier Logo
9:35 pm - 7:37 pm
SFO
-
TYS
19h 02m
1 stop
Frontier Logo
8:32 pm - 11:38 am
TYS
-
SFO
18h 06m
1 stop
$261Frontier
Thu, Aug 20 - Mon, Aug 24
American Airlines Logo
9:08 am - 10:24 pm
SFO
-
TYS
10h 16m
1 stop
American Airlines Logo
2:06 pm - 9:28 pm
TYS
-
SFO
10h 22m
1 stop
$278American Airlines
Mon, Apr 20 - Wed, Apr 22
Frontier Logo
6:00 am - 7:37 pm
SFO
-
TYS
10h 37m
1 stop
Frontier Logo
8:32 pm - 11:38 am
TYS
-
SFO
18h 06m
1 stop
$281Frontier
Wed, Jul 29 - Fri, Aug 7
Frontier Logo
6:00 am - 3:33 pm
SFO
-
TYS
6h 33m
1 stop
Frontier Logo
4:28 pm - 9:13 am
TYS
-
SFO
19h 45m
1 stop
$286Frontier
Sun, Apr 26 - Sun, May 3
Frontier Logo
6:00 am - 7:37 pm
SFO
-
TYS
10h 37m
1 stop
Frontier Logo
8:32 pm - 11:38 am
TYS
-
SFO
18h 06m
1 stop
$301Frontier
Wed, Jul 15 - Mon, Jul 20
Multiple Airlines Logo
12:52 pm - 1:59 pm
SFO
-
TYS
22h 07m
1 stop
Multiple Airlines Logo
7:24 pm - 8:01 am
TYS
-
SFO
39h 37m
2 stops
$321Multiple Airlines
Wed, May 20 - Mon, May 25
American Airlines Logo
11:49 pm - 10:26 am
SFO
-
TYS
7h 37m
1 stop
American Airlines Logo
5:06 pm - 11:59 pm
TYS
-
SFO
9h 53m
1 stop
$324American Airlines
Fri, Apr 24 - Tue, Apr 28

Delta flights from San Francisco to Knoxville

Our best Delta deals on San Francisco to Knoxville flight tickets
Delta
Apr 10
SFO10:40 pmSan Francisco
9h 00m
1 stop
TYS10:40 amKnoxville McGhee Tyson
Apr 15
TYS5:40 amKnoxville McGhee Tyson
9h 53m
1 stop
SFO12:33 pmSan Francisco
$363
Delta
May 7
SFO11:59 pmSan Francisco
7h 22m
1 stop
TYS10:21 amKnoxville McGhee Tyson
May 10
TYS6:36 amKnoxville McGhee Tyson
7h 41m
1 stop
SFO11:17 amSan Francisco
$397
Delta
Jun 8
SFO5:32 amSan Francisco
9h 25m
1 stop
TYS5:57 pmKnoxville McGhee Tyson
Jun 18
TYS3:54 pmKnoxville McGhee Tyson
9h 55m
1 stop
SFO10:49 pmSan Francisco
$402

Frontier flights from San Francisco to Knoxville

Our best Frontier deals on San Francisco to Knoxville flight tickets
Frontier
Apr 12
SFO9:00 pmSan Francisco
15h 28m
1 stop
TYS3:28 pmKnoxville McGhee Tyson
Apr 19
TYS4:28 pmKnoxville McGhee Tyson
19h 45m
1 stop
SFO9:13 amSan Francisco
$226
Frontier
Apr 12
SFO9:00 pmSan Francisco
15h 28m
1 stop
TYS3:28 pmKnoxville McGhee Tyson
Apr 16
TYS4:28 pmKnoxville McGhee Tyson
19h 45m
1 stop
SFO9:13 amSan Francisco
$242
Frontier
May 24
SFO12:52 pmSan Francisco
27h 41m
1 stop
TYS7:33 pmKnoxville McGhee Tyson
Jun 1
TYS8:32 pmKnoxville McGhee Tyson
18h 10m
1 stop
SFO11:42 amSan Francisco
$246

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 30, 2026.
Use the filters below to find and compare flights from San Francisco to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sun 4/12

9:00 pm-3:28 pm

1 stop15h 28m

Knoxville McGhee Tyson

Sun 4/19

4:28 pm-9:13 am

1 stop19h 45m

$226

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sun 4/12

9:00 pm-3:28 pm

1 stop15h 28m

Knoxville McGhee Tyson

Thu 4/16

4:28 pm-9:13 am

1 stop19h 45m

$242

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sun 5/24

12:52 pm-7:33 pm

1 stop27h 41m

Knoxville McGhee Tyson

Mon 6/1

8:32 pm-11:42 am

1 stop18h 10m

$246

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 8/20

9:35 pm-7:37 pm

1 stop19h 02m

Knoxville McGhee Tyson

Mon 8/24

8:32 pm-11:38 am

1 stop18h 06m

$261

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 4/20

9:08 am-10:24 pm

1 stop10h 16m

Knoxville McGhee Tyson

Wed 4/22

2:06 pm-9:28 pm

1 stop10h 22m

$278

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Wed 7/29

6:00 am-7:37 pm

1 stop10h 37m

Knoxville McGhee Tyson

Fri 8/7

8:32 pm-11:38 am

1 stop18h 06m

$281

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sun 4/26

6:00 am-3:33 pm

1 stop6h 33m

Knoxville McGhee Tyson

Sun 5/3

4:28 pm-9:13 am

1 stop19h 45m

$286

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Wed 7/15

6:00 am-7:37 pm

1 stop10h 37m

Knoxville McGhee Tyson

Mon 7/20

8:32 pm-11:38 am

1 stop18h 06m

$301

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Wed 5/20

12:52 pm-1:59 pm

1 stop22h 07m

Knoxville McGhee Tyson

Mon 5/25

7:24 pm-8:01 am

2 stops39h 37m

$321
Quickest round-trip

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Fri 4/24

11:49 pm-10:26 am

1 stop7h 37m

Knoxville McGhee Tyson

Tue 4/28

5:06 pm-11:59 pm

1 stop9h 53m

$324

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from San Francisco to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Francisco and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from San Francisco, with most prices found around $383. If you aren’t able to travel during the month of August, then book flights to Knoxville from San Francisco during July instead. Flights to Knoxville in July, while not as cheap as those in August, still average around $403.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $471 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from San Francisco for as low as $334 on momondo.

How have San Francisco to Knoxville flight prices changed over time?

As of March 2026, prices for San Francisco to Knoxville flights are approximately 2% cheaper when compared to flights at the same time last year.

When to book flights from San Francisco to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Knoxville (SFO to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Knoxville

Fastest flight time

6h 28m

Direct flights

None
The fastest flight from San Francisco to Knoxville takes 6h 28m
There are no direct flights from San Francisco to Knoxville. There are no popular flight routes from San Francisco to Knoxville.
Search flight deals

  • How far is San Francisco to Knoxville McGhee Tyson by plane?

    The straight-line distance from San Francisco to Knoxville McGhee Tyson is 2114.2 mi. In terms of flight time, this usually takes a little over 6h 28m.

  • When did momondo last update prices for flights from San Francisco Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Francisco Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Francisco Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Francisco Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from San Francisco to Knoxville?

  • What is the most popular airline from San Francisco to Knoxville?

Best airlines flying from San Francisco to Knoxville

Compare and see reviews for airlines that fly from San Francisco to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $89Free CancellationRating
5.7
3,010 reviews
Search Frontier flights
DeltaPriceFrom $308Free CancellationRating
7.9
8,358 reviews
Search Delta flights
American AirlinesPriceFrom $308Free CancellationRating
7.1
11,531 reviews
Search American Airlines flights
United AirlinesPriceFrom $328Free CancellationRating
7.4
9,514 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Francisco to Knoxville for you.

Can I find flights from San Francisco to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for San Francisco to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from San Francisco to Knoxville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from San Francisco to Knoxville.

I’m not ready to book a flight from San Francisco to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Francisco to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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