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Cheap flights from San Francisco to Knoxville from $93

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Knoxville departing on 11/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

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Frontier Logo
9:03 am - 3:53 pmSFO-TYS
27h 50m2 stops
Frontier Logo
4:52 pm - 7:53 amTYS-SFO
18h 01m1 stop
$223Frontier
Find Deal
Thu, Nov 20 - Thu, Dec 4
Multiple Airlines Logo
2:13 pm - 5:02 pmSFO-TYS
23h 49m1 stop
Multiple Airlines Logo
4:52 pm - 7:53 amTYS-SFO
18h 01m1 stop
$241Multiple Airlines
Find Deal
Thu, Dec 4 - Sun, Dec 7
Multiple Airlines Logo
9:03 pm - 5:02 pmSFO-TYS
16h 59m2 stops
Multiple Airlines Logo
4:52 pm - 7:53 amTYS-SFO
18h 01m1 stop
$250Multiple Airlines
Find Deal
Thu, Dec 4 - Sun, Dec 7
Frontier Logo
2:54 pm - 3:53 pmSFO-TYS
21h 59m1 stop
Frontier Logo
4:52 pm - 7:53 amTYS-SFO
18h 01m1 stop
$262Frontier
Find Deal
Thu, Nov 20 - Thu, Dec 4
Multiple Airlines Logo
6:30 am - 3:57 pmSFO-TYS
30h 27m1 stop
Multiple Airlines Logo
5:56 pm - 9:11 pmTYS-SFO
30h 15m2 stops
$263Multiple Airlines
Find Deal
Sun, Dec 7 - Fri, Dec 12
Multiple Airlines Logo
6:30 am - 3:31 pmSFO-TYS
30h 01m1 stop
Multiple Airlines Logo
11:22 am - 9:08 pmTYS-SFO
36h 46m2 stops
$264Multiple Airlines
Find Deal
Wed, Dec 17 - Mon, Jan 5
American Airlines Logo
11:59 pm - 11:18 amSFO-TYS
8h 19m1 stop
American Airlines Logo
6:28 pm - 11:39 pmTYS-SFO
8h 11m1 stop
$329American Airlines
Find Deal
Fri, Apr 24 - Sat, May 9
American Airlines Logo
6:00 am - 5:27 pmSFO-TYS
8h 27m2 stops
American Airlines Logo
6:40 am - 12:31 pmTYS-SFO
8h 51m1 stop
$334American Airlines
Find Deal
Wed, Dec 3 - Sun, Dec 7
Southwest Logo
5:40 am - 8:05 pmSFO-TYS
11h 25m2 stops
Southwest Logo
6:30 am - 1:50 pmTYS-SFO
10h 20m2 stops
$364Southwest
Find Deal
Tue, Mar 31 - Mon, Apr 6
Southwest Logo
10:55 pm - 11:50 amSFO-TYS
9h 55m1 stop
Southwest Logo
6:30 am - 1:50 pmTYS-SFO
10h 20m2 stops
$365Southwest
Find Deal
Tue, Mar 31 - Mon, Apr 6

Southwest flights from San Francisco to Knoxville

Our best Southwest deals on San Francisco to Knoxville flight tickets
Southwest
Mar 31
SFO5:40 amSan Francisco
11h 25m
2 stops
TYS8:05 pmKnoxville McGhee Tyson
Apr 6
TYS6:30 amKnoxville McGhee Tyson
10h 20m
2 stops
SFO1:50 pmSan Francisco
$364
Find similar
Southwest
Mar 31
SFO10:55 pmSan Francisco
9h 55m
1 stop
TYS11:50 amKnoxville McGhee Tyson
Apr 6
TYS6:30 amKnoxville McGhee Tyson
10h 20m
2 stops
SFO1:50 pmSan Francisco
$365
Find similar

Frontier flights from San Francisco to Knoxville

Our best Frontier deals on San Francisco to Knoxville flight tickets
Frontier
Nov 20
SFO9:03 amSan Francisco
27h 50m
2 stops
TYS3:53 pmKnoxville McGhee Tyson
Dec 4
TYS4:52 pmKnoxville McGhee Tyson
18h 01m
1 stop
SFO7:53 amSan Francisco
$223
Find similar
Frontier
Nov 20
SFO2:54 pmSan Francisco
21h 59m
1 stop
TYS3:53 pmKnoxville McGhee Tyson
Dec 4
TYS4:52 pmKnoxville McGhee Tyson
18h 01m
1 stop
SFO7:53 amSan Francisco
$262
Find similar
Frontier
Nov 27
SFO2:54 pmSan Francisco
21h 59m
1 stop
TYS3:53 pmKnoxville McGhee Tyson
Dec 4
TYS4:52 pmKnoxville McGhee Tyson
10h 32m
1 stop
SFO12:24 amSan Francisco
$266
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from San Francisco to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 11/20

9:03 am-3:53 pm

2 stops27h 50m

Knoxville McGhee Tyson

Thu 12/4

4:52 pm-7:53 am

1 stop18h 01m

$223

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 12/4

2:13 pm-5:02 pm

1 stop23h 49m

Knoxville McGhee Tyson

Sun 12/7

4:52 pm-7:53 am

1 stop18h 01m

$241

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 12/4

9:03 pm-5:02 pm

2 stops16h 59m

Knoxville McGhee Tyson

Sun 12/7

4:52 pm-7:53 am

1 stop18h 01m

$250

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 11/20

2:54 pm-3:53 pm

1 stop21h 59m

Knoxville McGhee Tyson

Thu 12/4

4:52 pm-7:53 am

1 stop18h 01m

$262

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sun 12/7

6:30 am-3:57 pm

1 stop30h 27m

Knoxville McGhee Tyson

Fri 12/12

5:56 pm-9:11 pm

2 stops30h 15m

$263

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Wed 12/17

6:30 am-3:31 pm

1 stop30h 01m

Knoxville McGhee Tyson

Mon 1/5

11:22 am-9:08 pm

2 stops36h 46m

$264

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Fri 4/24

11:59 pm-11:18 am

1 stop8h 19m

Knoxville McGhee Tyson

Sat 5/9

6:28 pm-11:39 pm

1 stop8h 11m

$329

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Wed 12/3

6:00 am-5:27 pm

2 stops8h 27m

Knoxville McGhee Tyson

Sun 12/7

6:40 am-12:31 pm

1 stop8h 51m

$334

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Tue 3/31

5:40 am-8:05 pm

2 stops11h 25m

Knoxville McGhee Tyson

Mon 4/6

6:30 am-1:50 pm

2 stops10h 20m

$364

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Tue 3/31

10:55 pm-11:50 am

1 stop9h 55m

Knoxville McGhee Tyson

Mon 4/6

6:30 am-1:50 pm

2 stops10h 20m

$365

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from San Francisco to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Francisco and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from San Francisco, with most prices found around $382. If you aren’t able to travel during the month of August, then book flights to Knoxville from San Francisco during July instead. Flights to Knoxville in July, while not as cheap as those in August, still average around $397.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from San Francisco to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $425. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from San Francisco to Knoxville for around $555.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from San Francisco to Knoxville when you can find flight prices for as low as $453. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $514.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $475 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from San Francisco for as low as $372 on momondo.

How have San Francisco to Knoxville flight prices changed over time?

As of October 2025, prices for San Francisco to Knoxville flights are approximately 18% cheaper when compared to flights at the same time last year.

When to book flights from San Francisco to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Knoxville (SFO to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Knoxville

Direct flights

None
There are no direct flights from San Francisco to Knoxville. There are no popular flight routes from San Francisco to Knoxville.
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  • How far is San Francisco to Knoxville McGhee Tyson by plane?

    The straight-line distance from San Francisco to Knoxville McGhee Tyson is 2114.7 mi. In terms of flight time, this usually takes a little over 6h 07m.

  • When did momondo last update prices for flights from San Francisco Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Francisco Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Francisco Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Francisco Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from San Francisco to Knoxville?

  • What is the most popular airline from San Francisco to Knoxville?

Best airlines flying from San Francisco to Knoxville

Compare and see reviews for airlines that fly from San Francisco to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $149Free CancellationRating
5.8
3,122 reviews
Search Frontier flights
DeltaPriceFrom $308Free CancellationRating
7.9
7,998 reviews
Search Delta flights
American AirlinesPriceFrom $308Free CancellationRating
7.2
11,035 reviews
Search American Airlines flights
United AirlinesPriceFrom $370Free CancellationRating
7.4
8,998 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Francisco to Knoxville for you.

Can I find flights from San Francisco to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for San Francisco to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from San Francisco to Knoxville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from San Francisco to Knoxville.

I’m not ready to book a flight from San Francisco to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Francisco to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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