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Cheap flights from San Francisco to Knoxville from $152

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Knoxville departing on 10/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from San Francisco to Knoxville

Cheap round-trip flights

Frontier Logo
6:34 am - 7:32 pmSFO-TYS
9h 58m1 stop
Frontier Logo
8:17 pm - 12:14 amTYS-SFO
6h 57m1 stop
$168Frontier
Find Deal
Mon, Oct 20 - Thu, Oct 23
Frontier Logo
6:34 am - 7:32 pmSFO-TYS
9h 58m1 stop
Frontier Logo
8:17 pm - 12:14 amTYS-SFO
6h 57m1 stop
$205Frontier
Find Deal
Mon, Oct 20 - Thu, Oct 23
Multiple Airlines Logo
9:23 pm - 9:04 pmSFO-TYS
20h 41m1 stop
Multiple Airlines Logo
7:17 pm - 12:14 amTYS-SFO
7h 57m1 stop
$230Multiple Airlines
Find Deal
Fri, Oct 17 - Thu, Oct 30
Multiple Airlines Logo
8:00 am - 9:07 pmSFO-TYS
34h 07m2 stops
Multiple Airlines Logo
7:17 pm - 12:14 amTYS-SFO
7h 57m1 stop
$263Multiple Airlines
Find Deal
Wed, Oct 15 - Thu, Oct 30
Delta Logo
9:50 pm - 9:00 amSFO-TYS
8h 10m1 stop
Delta Logo
6:40 am - 1:30 pmTYS-SFO
9h 50m1 stop
$329Delta
Find Deal
Tue, Oct 14 - Wed, Oct 29
American Airlines Logo
1:10 pm - 12:08 amSFO-TYS
7h 58m2 stops
American Airlines Logo
6:18 pm - 11:25 pmTYS-SFO
8h 07m1 stop
$334American Airlines
Find Deal
Sat, Nov 8 - Tue, Nov 11
American Airlines Logo
11:59 pm - 11:28 amSFO-TYS
8h 29m1 stop
American Airlines Logo
7:48 am - 3:01 pmTYS-SFO
10h 13m1 stop
$351American Airlines
Find Deal
Thu, Dec 25 - Wed, Dec 31
Delta Logo
10:57 pm - 11:04 amSFO-TYS
9h 07m1 stop
Delta Logo
5:16 pm - 12:05 amTYS-SFO
9h 49m1 stop
$364Delta
Find Deal
Mon, Oct 13 - Tue, Oct 28
United Airlines Logo
12:43 am - 1:35 pmSFO-TYS
9h 52m1 stop
United Airlines Logo
2:00 pm - 6:28 pmTYS-SFO
7h 28m1 stop
$371United Airlines
Find Deal
Tue, Oct 14 - Wed, Oct 22
United Airlines Logo
12:43 am - 1:35 pmSFO-TYS
9h 52m1 stop
United Airlines Logo
4:40 pm - 8:54 pmTYS-SFO
7h 14m1 stop
$372United Airlines
Find Deal
Tue, Oct 14 - Wed, Oct 22

Delta flights from San Francisco to Knoxville

Our best Delta deals on San Francisco to Knoxville flight tickets
Delta
Oct 14
SFO9:50 pmSan Francisco
8h 10m
1 stop
TYS9:00 amKnoxville McGhee Tyson
Oct 29
TYS6:40 amKnoxville McGhee Tyson
9h 50m
1 stop
SFO1:30 pmSan Francisco
$329
Find similar
Delta
Oct 13
SFO10:57 pmSan Francisco
9h 07m
1 stop
TYS11:04 amKnoxville McGhee Tyson
Oct 28
TYS5:16 pmKnoxville McGhee Tyson
9h 49m
1 stop
SFO12:05 amSan Francisco
$364
Find similar
Delta
Sep 27
SFO1:44 pmSan Francisco
7h 00m
1 stop
TYS11:44 pmKnoxville McGhee Tyson
Sep 30
TYS4:13 pmKnoxville McGhee Tyson
10h 16m
2 stops
SFO11:29 pmSan Francisco
$707
Find similar

Frontier flights from San Francisco to Knoxville

Our best Frontier deals on San Francisco to Knoxville flight tickets
Frontier
Oct 20
SFO6:34 amSan Francisco
9h 58m
1 stop
TYS7:32 pmKnoxville McGhee Tyson
Oct 23
TYS8:17 pmKnoxville McGhee Tyson
6h 57m
1 stop
SFO12:14 amSan Francisco
$168
Find similar
Frontier
Oct 20
SFO6:34 amSan Francisco
9h 58m
1 stop
TYS7:32 pmKnoxville McGhee Tyson
Oct 23
TYS8:17 pmKnoxville McGhee Tyson
6h 57m
1 stop
SFO12:14 amSan Francisco
$205
Find similar
Frontier
Oct 2
SFO6:29 amSan Francisco
10h 21m
1 stop
TYS7:50 pmKnoxville McGhee Tyson
Oct 9
TYS8:17 pmKnoxville McGhee Tyson
6h 57m
1 stop
SFO12:14 amSan Francisco
$206
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from San Francisco to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 10/20

6:34 am-7:32 pm

1 stop9h 58m

Knoxville McGhee Tyson

Thu 10/23

8:17 pm-12:14 am

1 stop6h 57m

$168

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 10/20

6:34 am-7:32 pm

1 stop9h 58m

Knoxville McGhee Tyson

Thu 10/23

8:17 pm-12:14 am

1 stop6h 57m

$205

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Fri 10/17

9:23 pm-9:04 pm

1 stop20h 41m

Knoxville McGhee Tyson

Thu 10/30

7:17 pm-12:14 am

1 stop7h 57m

$230

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Wed 10/15

8:00 am-9:07 pm

2 stops34h 07m

Knoxville McGhee Tyson

Thu 10/30

7:17 pm-12:14 am

1 stop7h 57m

$263

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Tue 10/14

9:50 pm-9:00 am

1 stop8h 10m

Knoxville McGhee Tyson

Wed 10/29

6:40 am-1:30 pm

1 stop9h 50m

$329

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Sat 11/8

1:10 pm-12:08 am

2 stops7h 58m

Knoxville McGhee Tyson

Tue 11/11

6:18 pm-11:25 pm

1 stop8h 07m

$334

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Thu 12/25

11:59 pm-11:28 am

1 stop8h 29m

Knoxville McGhee Tyson

Wed 12/31

7:48 am-3:01 pm

1 stop10h 13m

$351

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Mon 10/13

10:57 pm-11:04 am

1 stop9h 07m

Knoxville McGhee Tyson

Tue 10/28

5:16 pm-12:05 am

1 stop9h 49m

$364

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Tue 10/14

12:43 am-1:35 pm

1 stop9h 52m

Knoxville McGhee Tyson

Wed 10/22

2:00 pm-6:28 pm

1 stop7h 28m

$371

San FranciscoKnoxville

SFO - TYS

SFOTYS

San Francisco

Tue 10/14

12:43 am-1:35 pm

1 stop9h 52m

Knoxville McGhee Tyson

Wed 10/22

4:40 pm-8:54 pm

1 stop7h 14m

$372

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from San Francisco to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from San Francisco, with most prices found around $382. If you aren’t able to travel during the month of August, then book flights to Knoxville from San Francisco during July instead. Flights to Knoxville in July, while not as cheap as those in August, still average around $397.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from San Francisco to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $425. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from San Francisco to Knoxville for around $555.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from San Francisco to Knoxville when you can find flight prices for as low as $453. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $514.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $479 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from San Francisco for as low as $365 on momondo.

How have San Francisco to Knoxville flight prices changed over time?

As of September 2025, prices for San Francisco to Knoxville flights are approximately 39% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Knoxville (SFO to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Knoxville

Direct flights

None
There are no direct flights from San Francisco to Knoxville. There are no popular flight routes from San Francisco to Knoxville.
Search flight deals

  • How far is San Francisco to Knoxville McGhee Tyson by plane?

    The straight-line distance from San Francisco to Knoxville McGhee Tyson is 2114.7 mi. In terms of flight time, this usually takes a little over 7h 58m.

  • When did momondo last update prices for flights from San Francisco Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Francisco Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Francisco Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Francisco Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Francisco Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from San Francisco to Knoxville?

  • What is the most popular airline from San Francisco to Knoxville?

Best airlines flying from San Francisco to Knoxville

Compare and see reviews for airlines that fly from San Francisco to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $138Free CancellationRating
5.8
3,174 reviews
Search Frontier flights
DeltaPriceFrom $308Free CancellationRating
7.9
7,957 reviews
Search Delta flights
American AirlinesPriceFrom $308Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $338Free CancellationRating
7.4
8,924 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Newport
Lenoir City
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Francisco to Knoxville for you.

Can I find flights from San Francisco to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for San Francisco to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from San Francisco to Knoxville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from San Francisco to Knoxville.

I’m not ready to book a flight from San Francisco to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Francisco to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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