Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from San Francisco to Des Moines from $128

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Des Moines departing on 12/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from San Francisco to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
6:30 am - 7:03 pmSFO-DSM
10h 33m1 stop
Frontier Logo
7:58 pm - 12:24 amDSM-SFO
6h 26m1 stop
$202Frontier
Find Deal
Mon, Dec 8 - Fri, Dec 12
Frontier Logo
6:34 am - 1:47 pmSFO-DSM
5h 13m1 stop
Frontier Logo
2:34 pm - 12:14 amDSM-SFO
11h 40m1 stop
$258Frontier
Find Deal
Mon, Nov 10 - Fri, Nov 14
American Airlines Logo
8:20 am - 11:59 pmSFO-DSM
13h 39m1 stop
American Airlines Logo
7:50 am - 7:14 pmDSM-SFO
13h 24m1 stop
$357American Airlines
Find Deal
Sat, Dec 6 - Tue, Dec 9
American Airlines Logo
12:25 am - 1:19 pmSFO-DSM
10h 54m1 stop
American Airlines Logo
7:50 am - 4:03 pmDSM-SFO
10h 13m1 stop
$367American Airlines
Find Deal
Fri, Dec 5 - Tue, Dec 9
Southwest Logo
12:50 pm - 8:25 pmSFO-DSM
5h 35m1 stop
Southwest Logo
12:05 pm - 6:35 pmDSM-SFO
8h 30m2 stops
$373Southwest
Find Deal
Sat, Dec 6 - Tue, Dec 9
Southwest Logo
10:40 am - 9:20 pmSFO-DSM
8h 40m2 stops
Southwest Logo
12:05 pm - 6:35 pmDSM-SFO
8h 30m2 stops
$378Southwest
Find Deal
Sat, Dec 6 - Tue, Dec 9
Delta Logo
12:30 am - 10:21 amSFO-DSM
7h 51m1 stop
Delta Logo
11:01 am - 10:31 pmDSM-SFO
13h 30m2 stops
$408Delta
Find Deal
Fri, Dec 5 - Tue, Dec 9
Delta Logo
12:30 am - 10:21 amSFO-DSM
7h 51m1 stop
Delta Logo
11:01 am - 10:31 pmDSM-SFO
13h 30m2 stops
$446Delta
Find Deal
Sun, Dec 7 - Fri, Dec 12
United Airlines Logo
11:05 pm - 10:50 amSFO-DSM
9h 45m1 stop
United Airlines Logo
6:46 pm - 1:14 amDSM-SFO
8h 28m1 stop
$463United Airlines
Find Deal
Tue, Dec 23 - Tue, Dec 30
United Airlines Logo
9:24 pm - 12:38 pmSFO-DSM
13h 14m2 stops
United Airlines Logo
5:15 pm - 9:35 amDSM-SFO
18h 20m1 stop
$527United Airlines
Find Deal
Mon, Dec 1 - Fri, Dec 5

Frontier flights from San Francisco to Des Moines

Our best Frontier deals on San Francisco to Des Moines flight tickets
Frontier
Dec 8
SFO6:30 amSan Francisco
10h 33m
1 stop
DSM7:03 pmDes Moines
Dec 12
DSM7:58 pmDes Moines
6h 26m
1 stop
SFO12:24 amSan Francisco
$202
Find similar
Frontier
Nov 10
SFO6:34 amSan Francisco
5h 13m
1 stop
DSM1:47 pmDes Moines
Nov 14
DSM2:34 pmDes Moines
11h 40m
1 stop
SFO12:14 amSan Francisco
$258
Find similar
Frontier
Nov 6
SFO12:43 pmSan Francisco
23h 04m
1 stop
DSM1:47 pmDes Moines
Nov 10
DSM2:32 pmDes Moines
11h 42m
1 stop
SFO12:14 amSan Francisco
$272
Find similar

American Airlines flights from San Francisco to Des Moines

Our best American Airlines deals on San Francisco to Des Moines flight tickets
American Airlines
Dec 6
SFO8:20 amSan Francisco
13h 39m
1 stop
DSM11:59 pmDes Moines
Dec 9
DSM7:50 amDes Moines
13h 24m
1 stop
SFO7:14 pmSan Francisco
$357
Find similar
American Airlines
Dec 5
SFO12:25 amSan Francisco
10h 54m
1 stop
DSM1:19 pmDes Moines
Dec 9
DSM7:50 amDes Moines
10h 13m
1 stop
SFO4:03 pmSan Francisco
$367
Find similar
American Airlines
Dec 22
SFO3:51 pmSan Francisco
6h 38m
1 stop
DSM12:29 amDes Moines
Jan 7
DSM5:24 amDes Moines
12h 55m
1 stop
SFO4:19 pmSan Francisco
$398
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 27, 2025.
Use the filters below to find and compare flights from San Francisco to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 12/8

6:30 am-7:03 pm

1 stop10h 33m

Des Moines

Fri 12/12

7:58 pm-12:24 am

1 stop6h 26m

$202

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 11/10

6:34 am-1:47 pm

1 stop5h 13m

Des Moines

Fri 11/14

2:34 pm-12:14 am

1 stop11h 40m

$258

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Sat 12/6

8:20 am-11:59 pm

1 stop13h 39m

Des Moines

Tue 12/9

7:50 am-7:14 pm

1 stop13h 24m

$357

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Fri 12/5

12:25 am-1:19 pm

1 stop10h 54m

Des Moines

Tue 12/9

7:50 am-4:03 pm

1 stop10h 13m

$367

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Sat 12/6

12:50 pm-8:25 pm

1 stop5h 35m

Des Moines

Tue 12/9

12:05 pm-6:35 pm

2 stops8h 30m

$373

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Sat 12/6

10:40 am-9:20 pm

2 stops8h 40m

Des Moines

Tue 12/9

12:05 pm-6:35 pm

2 stops8h 30m

$378

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Fri 12/5

12:30 am-10:21 am

1 stop7h 51m

Des Moines

Tue 12/9

11:01 am-10:31 pm

2 stops13h 30m

$408

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Sun 12/7

12:30 am-10:21 am

1 stop7h 51m

Des Moines

Fri 12/12

11:01 am-10:31 pm

2 stops13h 30m

$446

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Tue 12/23

11:05 pm-10:50 am

1 stop9h 45m

Des Moines

Tue 12/30

6:46 pm-1:14 am

1 stop8h 28m

$463

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 12/1

9:24 pm-12:38 pm

2 stops13h 14m

Des Moines

Fri 12/5

5:15 pm-9:35 am

1 stop18h 20m

$527

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Des Moines from

How to get the cheapest flight ticket from San Francisco to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in September, then January is your next best option. Flight prices from San Francisco to Des Moines during January average around $397.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from San Francisco to Des Moines is on a Wednesday. Travelers who choose to depart for Des Moines on a Wednesday will often find tickets for as low as $397. Flights from San Francisco to Des Moines on a Sunday will generally be more expensive and average around $607. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is at noon. momondo users have found flights departing from San Francisco to Des Moines at noon for as low as $389. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the morning because they tend to be around $511. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest San Francisco to Des Moines flight route?

Fly from San Francisco to Des Moines for the best San Francisco - Des Moines flight prices

How far in advance should I book a flight to Des Moines?

You are more likely to see cheaper flights to Des Moines from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Des Moines for around $464 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Des Moines from San Francisco for as low as $361 on momondo.

What cabin class options are available on San Francisco to Des Moines flights?

There is only 1 cabin class available to choose from on San Francisco to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have San Francisco to Des Moines flight prices changed over time?

As of October 2025, prices for San Francisco to Des Moines flights are approximately 69% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Des Moines (SFO to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Des Moines

Direct flights

None
There are no direct flights from San Francisco to Des Moines. There are no popular flight routes from San Francisco to Des Moines.
Search flight deals

  • How far is San Francisco to Des Moines by plane?

    The distance between San Francisco and Des Moines is about 1544.3 mi. A reasonable flight in good conditions will take 5h 13m.

  • When did momondo last update prices for flights from San Francisco Airport to Des Moines Airport?

    Prices for flights from San Francisco Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from San Francisco Airport to Des Moines Airport?

  • How old do you have to be to fly from San Francisco Airport to Des Moines Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Francisco Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Francisco to Des Moines?

Best airlines flying from San Francisco to Des Moines

Compare and see reviews for airlines that fly from San Francisco to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $149Free CancellationRating
5.8
3,123 reviews
Search Frontier flights
DeltaPriceFrom $319Free CancellationRating
7.9
7,997 reviews
Search Delta flights
American AirlinesPriceFrom $341Free CancellationRating
7.2
11,030 reviews
Search American Airlines flights
SouthwestPriceFrom $356Free CancellationRating
8.0
4,235 reviews
Search Southwest flights
United AirlinesPriceFrom $365Free CancellationRating
7.4
8,999 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Newton
Johnston
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from San Francisco to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from San Francisco to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from San Francisco on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Francisco to Des Moines?

Once all potential San Francisco to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Francisco to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of San Francisco to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Des Moines trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Wed 11/26
Wed 12/3
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States