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Cheap flights from San Francisco to Des Moines from $91

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Des Moines departing on 6/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Francisco to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
6:00 am - 7:26 pm
SFO
-
DSM
11h 26m
1 stop
Frontier Logo
8:21 pm - 12:26 am
DSM
-
SFO
6h 05m
1 stop
$211Frontier
Wed, May 27 - Wed, Jun 3
Multiple Airlines Logo
9:00 pm - 12:59 pm
SFO
-
DSM
13h 59m
1 stop
Multiple Airlines Logo
10:26 pm - 1:29 pm
DSM
-
SFO
17h 03m
1 stop
$228Multiple Airlines
Tue, May 26 - Sun, May 31
Multiple Airlines Logo
9:00 pm - 12:59 pm
SFO
-
DSM
13h 59m
1 stop
Multiple Airlines Logo
9:17 pm - 1:29 pm
DSM
-
SFO
18h 12m
1 stop
$229Multiple Airlines
Tue, May 26 - Mon, Jun 1
Frontier Logo
6:00 am - 7:26 pm
SFO
-
DSM
11h 26m
1 stop
Frontier Logo
8:21 pm - 12:26 am
DSM
-
SFO
6h 05m
1 stop
$231Frontier
Wed, May 27 - Wed, Jun 3
Multiple Airlines Logo
6:00 am - 7:26 pm
SFO
-
DSM
11h 26m
1 stop
Multiple Airlines Logo
10:26 pm - 1:29 pm
DSM
-
SFO
17h 03m
1 stop
$233Multiple Airlines
Wed, May 27 - Sun, May 31
Multiple Airlines Logo
9:00 pm - 12:59 pm
SFO
-
DSM
13h 59m
1 stop
Multiple Airlines Logo
9:17 pm - 1:29 pm
DSM
-
SFO
18h 12m
1 stop
$239Multiple Airlines
Tue, May 26 - Mon, Jun 1
Multiple Airlines Logo
8:43 am - 8:44 pm
SFO
-
DSM
10h 01m
1 stop
Multiple Airlines Logo
9:17 pm - 6:25 pm
DSM
-
SFO
23h 08m
1 stop
$257Multiple Airlines
Thu, May 28 - Mon, Jun 1
Frontier Logo
6:00 am - 7:26 pm
SFO
-
DSM
11h 26m
1 stop
Frontier Logo
8:21 pm - 12:26 am
DSM
-
SFO
6h 05m
1 stop
$260Frontier
Wed, May 27 - Mon, Jun 1
Multiple Airlines Logo
2:16 pm - 8:44 pm
SFO
-
DSM
28h 28m
1 stop
Multiple Airlines Logo
10:26 pm - 1:29 pm
DSM
-
SFO
17h 03m
1 stop
$268Multiple Airlines
Wed, May 27 - Sun, May 31
Multiple Airlines Logo
10:24 pm - 10:48 pm
SFO
-
DSM
22h 24m
2 stops
Multiple Airlines Logo
9:17 pm - 1:29 pm
DSM
-
SFO
18h 12m
1 stop
$272Multiple Airlines
Thu, May 28 - Mon, Jun 1

Delta flights from San Francisco to Des Moines

Our best Delta deals on San Francisco to Des Moines flight tickets
Delta
May 26
SFO6:30 pmSan Francisco
13h 46m
2 stops
DSM10:16 amDes Moines
Jun 3
DSM7:01 amDes Moines
16h 09m
2 stops
SFO9:10 pmSan Francisco
$313
Delta
May 26
SFO6:30 pmSan Francisco
13h 46m
2 stops
DSM10:16 amDes Moines
May 30
DSM10:56 amDes Moines
12h 14m
2 stops
SFO9:10 pmSan Francisco
$351
Delta
May 26
SFO6:30 pmSan Francisco
13h 46m
2 stops
DSM10:16 amDes Moines
May 30
DSM10:56 amDes Moines
12h 14m
2 stops
SFO9:10 pmSan Francisco
$352

Frontier flights from San Francisco to Des Moines

Our best Frontier deals on San Francisco to Des Moines flight tickets
Frontier
May 27
SFO6:00 amSan Francisco
11h 26m
1 stop
DSM7:26 pmDes Moines
Jun 3
DSM8:21 pmDes Moines
6h 05m
1 stop
SFO12:26 amSan Francisco
$211
Frontier
May 27
SFO6:00 amSan Francisco
11h 26m
1 stop
DSM7:26 pmDes Moines
Jun 3
DSM8:21 pmDes Moines
6h 05m
1 stop
SFO12:26 amSan Francisco
$231
Frontier
May 27
SFO6:00 amSan Francisco
11h 26m
1 stop
DSM7:26 pmDes Moines
Jun 1
DSM8:21 pmDes Moines
6h 05m
1 stop
SFO12:26 amSan Francisco
$260

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 11, 2026.
Use the filters below to find and compare flights from San Francisco to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Wed 5/27

6:00 am-7:26 pm

1 stop11h 26m

Des Moines

Wed 6/3

8:21 pm-12:26 am

1 stop6h 05m

$211

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Tue 5/26

9:00 pm-12:59 pm

1 stop13h 59m

Des Moines

Sun 5/31

10:26 pm-1:29 pm

1 stop17h 03m

$228

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Tue 5/26

9:00 pm-12:59 pm

1 stop13h 59m

Des Moines

Mon 6/1

9:17 pm-1:29 pm

1 stop18h 12m

$229

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Wed 5/27

6:00 am-7:26 pm

1 stop11h 26m

Des Moines

Wed 6/3

8:21 pm-12:26 am

1 stop6h 05m

$231

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Wed 5/27

6:00 am-7:26 pm

1 stop11h 26m

Des Moines

Sun 5/31

10:26 pm-1:29 pm

1 stop17h 03m

$233

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Tue 5/26

9:00 pm-12:59 pm

1 stop13h 59m

Des Moines

Mon 6/1

9:17 pm-1:29 pm

1 stop18h 12m

$239

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 5/28

8:43 am-8:44 pm

1 stop10h 01m

Des Moines

Mon 6/1

9:17 pm-6:25 pm

1 stop23h 08m

$257

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Wed 5/27

6:00 am-7:26 pm

1 stop11h 26m

Des Moines

Mon 6/1

8:21 pm-12:26 am

1 stop6h 05m

$260

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Wed 5/27

2:16 pm-8:44 pm

1 stop28h 28m

Des Moines

Sun 5/31

10:26 pm-1:29 pm

1 stop17h 03m

$268

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 5/28

10:24 pm-10:48 pm

2 stops22h 24m

Des Moines

Mon 6/1

9:17 pm-1:29 pm

1 stop18h 12m

$272

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from San Francisco to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in February, then September is your next best option. Flight prices from San Francisco to Des Moines during September average around $302.

What is the cheapest San Francisco to Des Moines flight route?

Fly from San Francisco to Des Moines for the best San Francisco - Des Moines flight prices

How far in advance should I book a flight to Des Moines?

You are more likely to see cheaper flights to Des Moines from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Des Moines for around $497 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Des Moines from San Francisco for as low as $347 on momondo.

What cabin class options are available on San Francisco to Des Moines flights?

There is only 1 cabin class available to choose from on San Francisco to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have San Francisco to Des Moines flight prices changed over time?

As of March 2026, prices for San Francisco to Des Moines flights are approximately 35% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Des Moines (SFO to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Des Moines

Fastest flight time

5h 35m

Direct flights

None
The fastest flight from San Francisco to Des Moines takes 5h 35m
There are no direct flights from San Francisco to Des Moines. There are no popular flight routes from San Francisco to Des Moines.
Search flight deals

  • How far is San Francisco to Des Moines by plane?

    The distance between San Francisco and Des Moines is about 1544.3 mi. A reasonable flight in good conditions will take 5h 35m.

  • When did momondo last update prices for flights from San Francisco Airport to Des Moines Airport?

    Prices for flights from San Francisco Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from San Francisco Airport to Des Moines Airport?

  • How old do you have to be to fly from San Francisco Airport to Des Moines Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Francisco Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Francisco to Des Moines?

Best airlines flying from San Francisco to Des Moines

Compare and see reviews for airlines that fly from San Francisco to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $149Free CancellationRating
5.7
3,034 reviews
Search Frontier flights
DeltaPriceFrom $263Free CancellationRating
7.9
8,278 reviews
Search Delta flights
American AirlinesPriceFrom $334Free CancellationRating
7.1
11,419 reviews
Search American Airlines flights
SouthwestPriceFrom $346Free CancellationRating
8.0
4,317 reviews
Search Southwest flights
United AirlinesPriceFrom $366Free CancellationRating
7.4
9,414 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from San Francisco to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from San Francisco to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from San Francisco on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Francisco to Des Moines?

Once all potential San Francisco to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Francisco to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of San Francisco to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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