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Cheap flights from San Francisco to Des Moines from $105

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Des Moines departing on 6/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Francisco to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
6:00 am - 1:31 pm
SFO
-
DSM
5h 31m
1 stop
Frontier Logo
2:19 pm - 12:18 am
DSM
-
SFO
11h 59m
1 stop
$250Frontier
Mon, Jun 29 - Fri, Jul 10
Frontier Logo
6:00 am - 1:31 pm
SFO
-
DSM
5h 31m
1 stop
Frontier Logo
2:19 pm - 12:18 am
DSM
-
SFO
11h 59m
1 stop
$270Frontier
Mon, Jun 29 - Wed, Jul 22
Multiple Airlines Logo
9:31 am - 6:48 pm
SFO
-
DSM
31h 17m
2 stops
Multiple Airlines Logo
10:00 am - 2:26 pm
DSM
-
SFO
6h 26m
1 stop
$271Multiple Airlines
Thu, Aug 27 - Thu, Sep 3
Frontier Logo
6:00 am - 1:31 pm
SFO
-
DSM
5h 31m
1 stop
Frontier Logo
2:16 pm - 12:23 am
DSM
-
SFO
12h 07m
1 stop
$280Frontier
Mon, Jun 1 - Mon, Jun 8
Frontier Logo
9:39 pm - 1:34 pm
SFO
-
DSM
13h 55m
1 stop
Frontier Logo
2:19 pm - 12:18 am
DSM
-
SFO
11h 59m
1 stop
$282Frontier
Thu, Jul 30 - Mon, Aug 3
Multiple Airlines Logo
11:13 am - 12:59 pm
SFO
-
DSM
23h 46m
2 stops
Multiple Airlines Logo
9:33 pm - 7:53 pm
DSM
-
SFO
24h 20m
1 stop
$288Multiple Airlines
Tue, Jun 30 - Sun, Jul 12
Frontier Logo
6:00 am - 1:31 pm
SFO
-
DSM
5h 31m
1 stop
Frontier Logo
2:16 pm - 12:23 am
DSM
-
SFO
12h 07m
1 stop
$290Frontier
Fri, May 29 - Wed, Jun 3
Multiple Airlines Logo
10:45 pm - 12:55 pm
SFO
-
DSM
12h 10m
1 stop
Multiple Airlines Logo
9:01 pm - 8:49 am
DSM
-
SFO
13h 48m
1 stop
$293Multiple Airlines
Tue, Jun 2 - Thu, Jun 4
Multiple Airlines Logo
5:16 pm - 1:31 pm
SFO
-
DSM
18h 15m
2 stops
Multiple Airlines Logo
9:56 pm - 10:28 am
DSM
-
SFO
14h 32m
1 stop
$294Multiple Airlines
Tue, Jun 16 - Mon, Jun 22
Multiple Airlines Logo
10:50 pm - 7:48 pm
SFO
-
DSM
18h 58m
1 stop
Multiple Airlines Logo
7:38 pm - 8:46 am
DSM
-
SFO
15h 08m
1 stop
$299Multiple Airlines
Sun, Aug 23 - Fri, Aug 28

Alaska Airlines flights from San Francisco to Des Moines

Our best Alaska Airlines deals on San Francisco to Des Moines flight tickets
Alaska Airlines
May 20
SFO6:16 amSan Francisco
15h 43m
2 stops
DSM11:59 pmDes Moines
May 27
DSM9:41 amDes Moines
9h 20m
2 stops
SFO5:01 pmSan Francisco
$868
Alaska Airlines
May 20
SFO9:38 amSan Francisco
10h 15m
1 stop
DSM9:53 pmDes Moines
May 27
DSM9:41 amDes Moines
11h 39m
2 stops
SFO7:20 pmSan Francisco
$933
Alaska Airlines
May 21
SFO7:20 amSan Francisco
14h 37m
2 stops
DSM11:57 pmDes Moines
May 30
DSM5:00 amDes Moines
14h 01m
2 stops
SFO5:01 pmSan Francisco
$979

Delta flights from San Francisco to Des Moines

Our best Delta deals on San Francisco to Des Moines flight tickets
Delta
May 28
SFO6:00 amSan Francisco
9h 53m
1 stop
DSM5:53 pmDes Moines
Jun 7
DSM10:24 amDes Moines
9h 49m
1 stop
SFO6:13 pmSan Francisco
$503
Delta
May 28
SFO8:30 pmSan Francisco
11h 46m
2 stops
DSM10:16 amDes Moines
Jun 7
DSM6:38 pmDes Moines
8h 07m
1 stop
SFO12:45 amSan Francisco
$709
Delta
May 22
SFO11:59 pmSan Francisco
9h 09m
1 stop
DSM11:08 amDes Moines
May 24
DSM7:01 amDes Moines
6h 16m
1 stop
SFO11:17 amSan Francisco
$772

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 15, 2026.
Use the filters below to find and compare flights from San Francisco to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 6/29

6:00 am-1:31 pm

1 stop5h 31m

Des Moines

Fri 7/10

2:19 pm-12:18 am

1 stop11h 59m

$250

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 6/29

6:00 am-1:31 pm

1 stop5h 31m

Des Moines

Wed 7/22

2:19 pm-12:18 am

1 stop11h 59m

$270

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 8/27

9:31 am-6:48 pm

2 stops31h 17m

Des Moines

Thu 9/3

10:00 am-2:26 pm

1 stop6h 26m

$271

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 6/1

6:00 am-1:31 pm

1 stop5h 31m

Des Moines

Mon 6/8

2:16 pm-12:23 am

1 stop12h 07m

$280

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 7/30

9:39 pm-1:34 pm

1 stop13h 55m

Des Moines

Mon 8/3

2:19 pm-12:18 am

1 stop11h 59m

$282

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Tue 6/30

11:13 am-12:59 pm

2 stops23h 46m

Des Moines

Sun 7/12

9:33 pm-7:53 pm

1 stop24h 20m

$288

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Fri 5/29

6:00 am-1:31 pm

1 stop5h 31m

Des Moines

Wed 6/3

2:16 pm-12:23 am

1 stop12h 07m

$290

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Tue 6/2

10:45 pm-12:55 pm

1 stop12h 10m

Des Moines

Thu 6/4

9:01 pm-8:49 am

1 stop13h 48m

$293

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Tue 6/16

5:16 pm-1:31 pm

2 stops18h 15m

Des Moines

Mon 6/22

9:56 pm-10:28 am

1 stop14h 32m

$294

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Sun 8/23

10:50 pm-7:48 pm

1 stop18h 58m

Des Moines

Fri 8/28

7:38 pm-8:46 am

1 stop15h 08m

$299

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from San Francisco to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Francisco and Des Moines?

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in February, then September is your next best option. Flight prices from San Francisco to Des Moines during September average around $319.

How far in advance should I book a flight from San Francisco to Des Moines?

You are more likely to see cheaper flights to Des Moines from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Des Moines for around $550 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Des Moines from San Francisco for as low as $312 on momondo.

How have San Francisco to Des Moines flight prices changed over time?

As of May 2026, prices for San Francisco to Des Moines flights are approximately 103% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Des Moines (SFO to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Des Moines

Fastest flight time

5h 30m

Direct flights

None
The fastest flight from San Francisco to Des Moines takes 5h 30m
There are no direct flights from San Francisco to Des Moines. There are no popular flight routes from San Francisco to Des Moines.
Search flight deals

Frequently asked questions about flying from San Francisco to Des Moines

  • How far is San Francisco to Des Moines by plane?

    The distance between San Francisco and Des Moines is about 1543.9 mi. A reasonable flight in good conditions will take 5h 30m.

  • When did momondo last update prices for flights from San Francisco Airport to Des Moines Airport?

    Prices for flights from San Francisco Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from San Francisco Airport to Des Moines Airport?

  • How old do you have to be to fly from San Francisco Airport to Des Moines Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Francisco Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Francisco to Des Moines?

Best airlines flying from San Francisco to Des Moines

Compare and see reviews for airlines that fly from San Francisco to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $149Free CancellationRating
5.6
2,951 reviews
Search Frontier flights
DeltaPriceFrom $319Free CancellationRating
7.9
8,453 reviews
Search Delta flights
American AirlinesPriceFrom $341Free CancellationRating
7.1
11,662 reviews
Search American Airlines flights
SouthwestPriceFrom $346Free CancellationRating
8.0
4,299 reviews
Search Southwest flights
United AirlinesPriceFrom $386Free CancellationRating
7.4
9,717 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from San Francisco to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from San Francisco to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from San Francisco on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Francisco to Des Moines?

Once all potential San Francisco to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Francisco to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of San Francisco to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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