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Cheap flights from San Francisco to Des Moines from $102

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Des Moines departing on 6/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Francisco to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
6:00 am - 1:31 pm
SFO
-
DSM
5h 31m
1 stop
Frontier Logo
2:16 pm - 12:23 am
DSM
-
SFO
12h 07m
1 stop
$250Frontier
Fri, May 8 - Mon, May 11
Frontier Logo
6:00 am - 1:31 pm
SFO
-
DSM
5h 31m
1 stop
Frontier Logo
2:16 pm - 12:23 am
DSM
-
SFO
12h 07m
1 stop
$270Frontier
Fri, May 8 - Fri, May 15
Multiple Airlines Logo
5:25 pm - 1:31 pm
SFO
-
DSM
18h 06m
2 stops
Multiple Airlines Logo
9:56 pm - 10:27 am
DSM
-
SFO
14h 31m
1 stop
$276Multiple Airlines
Thu, Jun 4 - Mon, Jun 8
Multiple Airlines Logo
6:00 am - 1:31 pm
SFO
-
DSM
29h 31m
1 stop
Multiple Airlines Logo
9:56 pm - 10:27 am
DSM
-
SFO
14h 31m
1 stop
$280Multiple Airlines
Thu, Jun 4 - Mon, Jun 8
Frontier Logo
9:35 pm - 1:31 pm
SFO
-
DSM
13h 56m
1 stop
Frontier Logo
2:16 pm - 12:22 am
DSM
-
SFO
12h 06m
1 stop
$281Frontier
Thu, Jun 18 - Mon, Jun 22
Multiple Airlines Logo
8:44 pm - 8:44 pm
SFO
-
DSM
22h 00m
1 stop
Multiple Airlines Logo
10:26 pm - 7:49 pm
DSM
-
SFO
23h 23m
1 stop
$284Multiple Airlines
Wed, May 27 - Sun, May 31
Frontier Logo
11:56 am - 1:09 pm
SFO
-
DSM
23h 13m
1 stop
Frontier Logo
2:04 pm - 12:27 am
DSM
-
SFO
12h 23m
1 stop
$300Frontier
Thu, Apr 23 - Mon, Apr 27
Frontier Logo
9:35 pm - 1:31 pm
SFO
-
DSM
13h 56m
1 stop
Frontier Logo
2:16 pm - 11:38 am
DSM
-
SFO
23h 22m
1 stop
$301Frontier
Thu, Jul 16 - Mon, Jul 20
Multiple Airlines Logo
10:50 pm - 1:31 pm
SFO
-
DSM
36h 41m
2 stops
Multiple Airlines Logo
8:00 am - 4:16 pm
DSM
-
SFO
10h 16m
1 stop
$302Multiple Airlines
Mon, Jun 29 - Wed, Jul 15
Frontier Logo
6:00 am - 7:38 pm
SFO
-
DSM
11h 38m
1 stop
Frontier Logo
2:16 pm - 12:23 am
DSM
-
SFO
12h 07m
1 stop
$306Frontier
Mon, May 4 - Fri, May 8

Frontier flights from San Francisco to Des Moines

Our best Frontier deals on San Francisco to Des Moines flight tickets
Frontier
May 8
SFO6:00 amSan Francisco
5h 31m
1 stop
DSM1:31 pmDes Moines
May 11
DSM2:16 pmDes Moines
12h 07m
1 stop
SFO12:23 amSan Francisco
$250
Frontier
May 8
SFO6:00 amSan Francisco
5h 31m
1 stop
DSM1:31 pmDes Moines
May 15
DSM2:16 pmDes Moines
12h 07m
1 stop
SFO12:23 amSan Francisco
$270
Frontier
Jun 18
SFO9:35 pmSan Francisco
13h 56m
1 stop
DSM1:31 pmDes Moines
Jun 22
DSM2:16 pmDes Moines
12h 06m
1 stop
SFO12:22 amSan Francisco
$281

Delta flights from San Francisco to Des Moines

Our best Delta deals on San Francisco to Des Moines flight tickets
Delta
May 5
SFO4:17 pmSan Francisco
15h 59m
2 stops
DSM10:16 amDes Moines
May 7
DSM5:28 pmDes Moines
8h 22m
1 stop
SFO11:50 pmSan Francisco
$373
Delta
Apr 20
SFO11:59 pmSan Francisco
8h 17m
1 stop
DSM10:16 amDes Moines
Apr 29
DSM7:00 amDes Moines
18h 10m
2 stops
SFO11:10 pmSan Francisco
$477
Delta
Apr 21
SFO1:10 pmSan Francisco
19h 06m
2 stops
DSM10:16 amDes Moines
Apr 29
DSM7:00 amDes Moines
14h 56m
2 stops
SFO7:56 pmSan Francisco
$489

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 9, 2026.
Use the filters below to find and compare flights from San Francisco to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Fri 5/8

6:00 am-1:31 pm

1 stop5h 31m

Des Moines

Mon 5/11

2:16 pm-12:23 am

1 stop12h 07m

$250

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Fri 5/8

6:00 am-1:31 pm

1 stop5h 31m

Des Moines

Fri 5/15

2:16 pm-12:23 am

1 stop12h 07m

$270

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 6/4

5:25 pm-1:31 pm

2 stops18h 06m

Des Moines

Mon 6/8

9:56 pm-10:27 am

1 stop14h 31m

$276

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 6/4

6:00 am-1:31 pm

1 stop29h 31m

Des Moines

Mon 6/8

9:56 pm-10:27 am

1 stop14h 31m

$280

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 6/18

9:35 pm-1:31 pm

1 stop13h 56m

Des Moines

Mon 6/22

2:16 pm-12:22 am

1 stop12h 06m

$281

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Wed 5/27

8:44 pm-8:44 pm

1 stop22h 00m

Des Moines

Sun 5/31

10:26 pm-7:49 pm

1 stop23h 23m

$284

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 4/23

11:56 am-1:09 pm

1 stop23h 13m

Des Moines

Mon 4/27

2:04 pm-12:27 am

1 stop12h 23m

$300

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 7/16

9:35 pm-1:31 pm

1 stop13h 56m

Des Moines

Mon 7/20

2:16 pm-11:38 am

1 stop23h 22m

$301

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 6/29

10:50 pm-1:31 pm

2 stops36h 41m

Des Moines

Wed 7/15

8:00 am-4:16 pm

1 stop10h 16m

$302

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 5/4

6:00 am-7:38 pm

1 stop11h 38m

Des Moines

Fri 5/8

2:16 pm-12:23 am

1 stop12h 07m

$306

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from San Francisco to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Francisco and Des Moines?

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in February, then September is your next best option. Flight prices from San Francisco to Des Moines during September average around $319.

What is the cheapest San Francisco to Des Moines flight route?

Fly from San Francisco to Des Moines for the best San Francisco - Des Moines flight prices

How far in advance should I book a flight to Des Moines?

You are more likely to see cheaper flights to Des Moines from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Des Moines for around $513 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Des Moines from San Francisco for as low as $321 on momondo.

What cabin class options are available on San Francisco to Des Moines flights?

There is only 1 cabin class available to choose from on San Francisco to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have San Francisco to Des Moines flight prices changed over time?

As of April 2026, prices for San Francisco to Des Moines flights are approximately 111% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Des Moines (SFO to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Des Moines

Fastest flight time

5h 52m

Direct flights

None
The fastest flight from San Francisco to Des Moines takes 5h 52m
There are no direct flights from San Francisco to Des Moines. There are no popular flight routes from San Francisco to Des Moines.
Search flight deals

Frequently asked questions about flying from San Francisco to Des Moines

  • How far is San Francisco to Des Moines by plane?

    The distance between San Francisco and Des Moines is about 1543.9 mi. A reasonable flight in good conditions will take 5h 52m.

  • When did momondo last update prices for flights from San Francisco Airport to Des Moines Airport?

    Prices for flights from San Francisco Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from San Francisco Airport to Des Moines Airport?

  • How old do you have to be to fly from San Francisco Airport to Des Moines Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Francisco Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Francisco to Des Moines?

Best airlines flying from San Francisco to Des Moines

Compare and see reviews for airlines that fly from San Francisco to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $149Free CancellationRating
5.7
2,995 reviews
Search Frontier flights
DeltaPriceFrom $295Free CancellationRating
7.9
8,392 reviews
Search Delta flights
American AirlinesPriceFrom $334Free CancellationRating
7.1
11,560 reviews
Search American Airlines flights
SouthwestPriceFrom $346Free CancellationRating
8.0
4,338 reviews
Search Southwest flights
United AirlinesPriceFrom $386Free CancellationRating
7.4
9,554 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from San Francisco to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from San Francisco to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from San Francisco on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Francisco to Des Moines?

Once all potential San Francisco to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Francisco to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of San Francisco to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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