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Cheap flights from San Francisco to Des Moines from $99

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Des Moines departing on 10/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from San Francisco to Des Moines

Cheap round-trip flights

Frontier Logo
6:34 am - 1:52 pmSFO-DSM
5h 18m1 stop
Frontier Logo
2:37 pm - 10:27 pmDSM-SFO
9h 50m1 stop
$149Frontier
Find Deal
Wed, Oct 15 - Wed, Oct 22
Frontier Logo
6:29 am - 1:40 pmSFO-DSM
5h 11m1 stop
Frontier Logo
2:37 pm - 10:27 pmDSM-SFO
9h 50m1 stop
$173Frontier
Find Deal
Sun, Sep 28 - Wed, Oct 8
Frontier Logo
6:34 am - 1:47 pmSFO-DSM
29h 13m1 stop
Frontier Logo
2:32 pm - 12:14 amDSM-SFO
11h 42m1 stop
$178Frontier
Find Deal
Wed, Nov 5 - Mon, Nov 17
Frontier Logo
6:34 am - 1:52 pmSFO-DSM
5h 18m1 stop
Frontier Logo
2:37 pm - 8:44 amDSM-SFO
20h 07m2 stops
$189Frontier
Find Deal
Wed, Oct 15 - Wed, Oct 22
Frontier Logo
6:34 am - 1:52 pmSFO-DSM
5h 18m1 stop
Frontier Logo
2:37 pm - 12:14 amDSM-SFO
11h 37m1 stop
$190Frontier
Find Deal
Thu, Oct 16 - Thu, Oct 23
Frontier Logo
8:09 pm - 1:47 pmSFO-DSM
15h 38m1 stop
Frontier Logo
2:32 pm - 12:14 amDSM-SFO
11h 42m1 stop
$210Frontier
Find Deal
Sun, Nov 2 - Mon, Nov 17
Frontier Logo
6:29 am - 1:40 pmSFO-DSM
5h 11m1 stop
Frontier Logo
2:25 pm - 12:16 amDSM-SFO
11h 51m1 stop
$211Frontier
Find Deal
Mon, Sep 29 - Thu, Oct 2
Frontier Logo
8:00 am - 1:47 pmSFO-DSM
27h 47m2 stops
Frontier Logo
2:32 pm - 12:14 amDSM-SFO
11h 42m1 stop
$214Frontier
Find Deal
Wed, Nov 5 - Mon, Nov 17
Multiple Airlines Logo
8:55 pm - 10:13 amSFO-DSM
11h 18m1 stop
Multiple Airlines Logo
2:32 pm - 2:40 pmDSM-SFO
26h 08m1 stop
$220Multiple Airlines
Find Deal
Thu, Nov 6 - Sun, Nov 16
Multiple Airlines Logo
10:25 pm - 11:44 amSFO-DSM
11h 19m1 stop
Multiple Airlines Logo
7:30 am - 9:22 pmDSM-SFO
15h 52m1 stop
$227Multiple Airlines
Find Deal
Thu, Oct 9 - Wed, Oct 15

Frontier flights from San Francisco to Des Moines

Our best Frontier deals on San Francisco to Des Moines flight tickets
Frontier
Oct 15
SFO6:34 amSan Francisco
5h 18m
1 stop
DSM1:52 pmDes Moines
Oct 22
DSM2:37 pmDes Moines
9h 50m
1 stop
SFO10:27 pmSan Francisco
$149
Find similar
Frontier
Sep 28
SFO6:29 amSan Francisco
5h 11m
1 stop
DSM1:40 pmDes Moines
Oct 8
DSM2:37 pmDes Moines
9h 50m
1 stop
SFO10:27 pmSan Francisco
$173
Find similar
Frontier
Nov 5
SFO6:34 amSan Francisco
29h 13m
1 stop
DSM1:47 pmDes Moines
Nov 17
DSM2:32 pmDes Moines
11h 42m
1 stop
SFO12:14 amSan Francisco
$178
Find similar

Southwest flights from San Francisco to Des Moines

Our best Southwest deals on San Francisco to Des Moines flight tickets
Southwest
Oct 1
SFO12:20 pmSan Francisco
7h 05m
1 stop
DSM9:25 pmDes Moines
Oct 4
DSM7:25 amDes Moines
11h 20m
2 stops
SFO4:45 pmSan Francisco
$552
Find similar
Southwest
Sep 30
SFO9:55 amSan Francisco
9h 30m
2 stops
DSM9:25 pmDes Moines
Oct 9
DSM11:45 amDes Moines
8h 15m
2 stops
SFO6:00 pmSan Francisco
$557
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from San Francisco to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Wed 10/15

6:34 am-1:52 pm

1 stop5h 18m

Des Moines

Wed 10/22

2:37 pm-10:27 pm

1 stop9h 50m

$149

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Sun 9/28

6:29 am-1:40 pm

1 stop5h 11m

Des Moines

Wed 10/8

2:37 pm-10:27 pm

1 stop9h 50m

$173

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Wed 11/5

6:34 am-1:47 pm

1 stop29h 13m

Des Moines

Mon 11/17

2:32 pm-12:14 am

1 stop11h 42m

$178

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Wed 10/15

6:34 am-1:52 pm

1 stop5h 18m

Des Moines

Wed 10/22

2:37 pm-8:44 am

2 stops20h 07m

$189

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 10/16

6:34 am-1:52 pm

1 stop5h 18m

Des Moines

Thu 10/23

2:37 pm-12:14 am

1 stop11h 37m

$190

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Sun 11/2

8:09 pm-1:47 pm

1 stop15h 38m

Des Moines

Mon 11/17

2:32 pm-12:14 am

1 stop11h 42m

$210

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 9/29

6:29 am-1:40 pm

1 stop5h 11m

Des Moines

Thu 10/2

2:25 pm-12:16 am

1 stop11h 51m

$211

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Wed 11/5

8:00 am-1:47 pm

2 stops27h 47m

Des Moines

Mon 11/17

2:32 pm-12:14 am

1 stop11h 42m

$214

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 11/6

8:55 pm-10:13 am

1 stop11h 18m

Des Moines

Sun 11/16

2:32 pm-2:40 pm

1 stop26h 08m

$220

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 10/9

10:25 pm-11:44 am

1 stop11h 19m

Des Moines

Wed 10/15

7:30 am-9:22 pm

1 stop15h 52m

$227

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from San Francisco to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Francisco and Des Moines?

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in September, then January is your next best option. Flight prices from San Francisco to Des Moines during January average around $397.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from San Francisco to Des Moines is on a Wednesday. Travelers who choose to depart for Des Moines on a Wednesday will often find tickets for as low as $397. Flights from San Francisco to Des Moines on a Sunday will generally be more expensive and average around $607. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is at noon. momondo users have found flights departing from San Francisco to Des Moines at noon for as low as $389. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the morning because they tend to be around $511. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest San Francisco to Des Moines flight route?

Fly from San Francisco to Des Moines for the best San Francisco - Des Moines flight prices

How far in advance should I book a flight to Des Moines?

You are more likely to see cheaper flights to Des Moines from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Des Moines for around $453 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Des Moines from San Francisco for as low as $365 on momondo.

What cabin class options are available on San Francisco to Des Moines flights?

There is only 1 cabin class available to choose from on San Francisco to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have San Francisco to Des Moines flight prices changed over time?

As of September 2025, prices for San Francisco to Des Moines flights are approximately 111% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Des Moines (SFO to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Des Moines

Direct flights

None
There are no direct flights from San Francisco to Des Moines. There are no popular flight routes from San Francisco to Des Moines.
Search flight deals

  • How far is San Francisco to Des Moines by plane?

    The distance between San Francisco and Des Moines is about 1544.3 mi. A reasonable flight in good conditions will take 5h 11m.

  • When did momondo last update prices for flights from San Francisco Airport to Des Moines Airport?

    Prices for flights from San Francisco Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from San Francisco Airport to Des Moines Airport?

  • How old do you have to be to fly from San Francisco Airport to Des Moines Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Francisco Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Francisco to Des Moines?

Best airlines flying from San Francisco to Des Moines

Compare and see reviews for airlines that fly from San Francisco to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $138Free CancellationRating
5.8
3,173 reviews
Search Frontier flights
DeltaPriceFrom $319Free CancellationRating
7.9
7,961 reviews
Search Delta flights
American AirlinesPriceFrom $341Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
SouthwestPriceFrom $356Free CancellationRating
8.0
4,242 reviews
Search Southwest flights
United AirlinesPriceFrom $388Free CancellationRating
7.4
8,926 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Newton
Osceola
Johnston
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from San Francisco to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from San Francisco to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from San Francisco on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Francisco to Des Moines?

Once all potential San Francisco to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Francisco to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of San Francisco to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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