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Cheap flights from San Francisco to Des Moines from $105

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Des Moines departing on 5/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from San Francisco to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
6:00 am - 7:38 pm
SFO
-
DSM
11h 38m
1 stop
Frontier Logo
2:16 pm - 12:23 am
DSM
-
SFO
12h 07m
1 stop
$225Frontier
Mon, May 4 - Fri, May 15
Frontier Logo
6:00 am - 1:31 pm
SFO
-
DSM
5h 31m
1 stop
Frontier Logo
2:16 pm - 12:23 am
DSM
-
SFO
12h 07m
1 stop
$271Frontier
Fri, May 8 - Fri, May 15
Frontier Logo
6:00 am - 1:31 pm
SFO
-
DSM
5h 31m
1 stop
Frontier Logo
2:16 pm - 12:23 am
DSM
-
SFO
12h 07m
1 stop
$290Frontier
Wed, May 27 - Fri, May 29
Frontier Logo
6:00 am - 1:31 pm
SFO
-
DSM
5h 31m
1 stop
Frontier Logo
2:16 pm - 12:23 am
DSM
-
SFO
12h 07m
1 stop
$300Frontier
Fri, May 8 - Fri, May 15
Multiple Airlines Logo
8:48 pm - 8:52 pm
SFO
-
DSM
22h 04m
2 stops
Multiple Airlines Logo
9:17 pm - 10:30 am
DSM
-
SFO
15h 13m
1 stop
$311Multiple Airlines
Thu, May 21 - Mon, Jun 1
Multiple Airlines Logo
9:19 am - 9:11 pm
SFO
-
DSM
33h 52m
2 stops
Multiple Airlines Logo
3:32 pm - 8:30 am
DSM
-
SFO
18h 58m
1 stop
$327Multiple Airlines
Thu, May 7 - Fri, May 15
Frontier Logo
6:00 am - 1:31 pm
SFO
-
DSM
5h 31m
1 stop
Frontier Logo
2:16 pm - 12:27 am
DSM
-
SFO
12h 11m
1 stop
$329Frontier
Mon, Jun 15 - Wed, Jul 1
American Airlines Logo
7:00 am - 6:17 pm
SFO
-
DSM
9h 17m
1 stop
American Airlines Logo
1:08 pm - 10:40 pm
DSM
-
SFO
11h 32m
1 stop
$331American Airlines
Tue, Aug 11 - Mon, Aug 17
Multiple Airlines Logo
10:50 pm - 12:59 pm
SFO
-
DSM
12h 09m
1 stop
Multiple Airlines Logo
10:01 pm - 10:27 am
DSM
-
SFO
14h 26m
1 stop
$333Multiple Airlines
Tue, Jul 28 - Mon, Aug 3
Frontier Logo
6:00 am - 1:31 pm
SFO
-
DSM
5h 31m
1 stop
Frontier Logo
2:16 pm - 12:27 am
DSM
-
SFO
12h 11m
1 stop
$335Frontier
Mon, Jun 15 - Fri, Jun 26

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Frontier flights from San Francisco to Des Moines

Our best Frontier deals on San Francisco to Des Moines flight tickets
Frontier
May 4
SFO6:00 amSan Francisco
11h 38m
1 stop
DSM7:38 pmDes Moines
May 15
DSM2:16 pmDes Moines
12h 07m
1 stop
SFO12:23 amSan Francisco
$225
Frontier
May 8
SFO6:00 amSan Francisco
5h 31m
1 stop
DSM1:31 pmDes Moines
May 15
DSM2:16 pmDes Moines
12h 07m
1 stop
SFO12:23 amSan Francisco
$271
Frontier
May 27
SFO6:00 amSan Francisco
5h 31m
1 stop
DSM1:31 pmDes Moines
May 29
DSM2:16 pmDes Moines
12h 07m
1 stop
SFO12:23 amSan Francisco
$290

American Airlines flights from San Francisco to Des Moines

Our best American Airlines deals on San Francisco to Des Moines flight tickets
American Airlines
Aug 11
SFO7:00 amSan Francisco
9h 17m
1 stop
DSM6:17 pmDes Moines
Aug 17
DSM1:08 pmDes Moines
11h 32m
1 stop
SFO10:40 pmSan Francisco
$331
American Airlines
Jun 23
SFO6:00 amSan Francisco
10h 17m
1 stop
DSM6:17 pmDes Moines
Jun 30
DSM6:47 pmDes Moines
15h 47m
1 stop
SFO8:34 amSan Francisco
$371
American Airlines
May 5
SFO11:28 pmSan Francisco
8h 58m
1 stop
DSM10:26 amDes Moines
May 11
DSM6:56 pmDes Moines
6h 55m
1 stop
SFO11:51 pmSan Francisco
$493

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 22, 2026.
Use the filters below to find and compare flights from San Francisco to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 5/4

6:00 am-7:38 pm

1 stop11h 38m

Des Moines

Fri 5/15

2:16 pm-12:23 am

1 stop12h 07m

$225
Quickest round-trip

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Fri 5/8

6:00 am-1:31 pm

1 stop5h 31m

Des Moines

Fri 5/15

2:16 pm-12:23 am

1 stop12h 07m

$271

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Wed 5/27

6:00 am-1:31 pm

1 stop5h 31m

Des Moines

Fri 5/29

2:16 pm-12:23 am

1 stop12h 07m

$290

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Fri 5/8

6:00 am-1:31 pm

1 stop5h 31m

Des Moines

Fri 5/15

2:16 pm-12:23 am

1 stop12h 07m

$300

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 5/21

8:48 pm-8:52 pm

2 stops22h 04m

Des Moines

Mon 6/1

9:17 pm-10:30 am

1 stop15h 13m

$311

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 5/7

9:19 am-9:11 pm

2 stops33h 52m

Des Moines

Fri 5/15

3:32 pm-8:30 am

1 stop18h 58m

$327

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 6/15

6:00 am-1:31 pm

1 stop5h 31m

Des Moines

Wed 7/1

2:16 pm-12:27 am

1 stop12h 11m

$329

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Tue 8/11

7:00 am-6:17 pm

1 stop9h 17m

Des Moines

Mon 8/17

1:08 pm-10:40 pm

1 stop11h 32m

$331

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Tue 7/28

10:50 pm-12:59 pm

1 stop12h 09m

Des Moines

Mon 8/3

10:01 pm-10:27 am

1 stop14h 26m

$333

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 6/15

6:00 am-1:31 pm

1 stop5h 31m

Des Moines

Fri 6/26

2:16 pm-12:27 am

1 stop12h 11m

$335

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from San Francisco to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Francisco and Des Moines?

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in February, then September is your next best option. Flight prices from San Francisco to Des Moines during September average around $319.

What is the cheapest San Francisco to Des Moines flight route?

Fly from San Francisco to Des Moines for the best San Francisco - Des Moines flight prices

How far in advance should I book a flight to Des Moines?

You are more likely to see cheaper flights to Des Moines from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Des Moines for around $513 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Des Moines from San Francisco for as low as $321 on momondo.

What cabin class options are available on San Francisco to Des Moines flights?

There is only 1 cabin class available to choose from on San Francisco to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have San Francisco to Des Moines flight prices changed over time?

As of April 2026, prices for San Francisco to Des Moines flights are approximately 112% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Des Moines (SFO to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Des Moines

Fastest flight time

5h 31m

Direct flights

None
The fastest flight from San Francisco to Des Moines takes 5h 31m
There are no direct flights from San Francisco to Des Moines. There are no popular flight routes from San Francisco to Des Moines.
Search flight deals

Frequently asked questions about flying from San Francisco to Des Moines

  • How far is San Francisco to Des Moines by plane?

    The distance between San Francisco and Des Moines is about 1543.9 mi. A reasonable flight in good conditions will take 5h 31m.

  • When did momondo last update prices for flights from San Francisco Airport to Des Moines Airport?

    Prices for flights from San Francisco Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from San Francisco Airport to Des Moines Airport?

  • How old do you have to be to fly from San Francisco Airport to Des Moines Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Francisco Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Francisco to Des Moines?

Best airlines flying from San Francisco to Des Moines

Compare and see reviews for airlines that fly from San Francisco to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $149Free CancellationRating
5.6
2,982 reviews
Search Frontier flights
DeltaPriceFrom $295Free CancellationRating
7.9
8,430 reviews
Search Delta flights
American AirlinesPriceFrom $334Free CancellationRating
7.1
11,647 reviews
Search American Airlines flights
SouthwestPriceFrom $346Free CancellationRating
8.0
4,330 reviews
Search Southwest flights
United AirlinesPriceFrom $386Free CancellationRating
7.4
9,625 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from San Francisco to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from San Francisco to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from San Francisco on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Francisco to Des Moines?

Once all potential San Francisco to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Francisco to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of San Francisco to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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