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Cheap flights from San Francisco to Des Moines from $141

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Des Moines departing on 2/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Francisco to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
6:30 am - 7:03 pmSFO-DSM
10h 33m1 stop
Frontier Logo
7:58 pm - 12:24 amDSM-SFO
6h 26m1 stop
$232Frontier
Find Deal
Mon, Dec 8 - Fri, Dec 12
Frontier Logo
6:30 am - 7:03 pmSFO-DSM
10h 33m1 stop
Frontier Logo
7:58 pm - 12:24 amDSM-SFO
6h 26m1 stop
$237Frontier
Find Deal
Mon, Dec 8 - Fri, Dec 12
Frontier Logo
4:07 pm - 7:03 pmSFO-DSM
24h 56m1 stop
Frontier Logo
7:58 pm - 12:24 amDSM-SFO
6h 26m1 stop
$254Frontier
Find Deal
Thu, Dec 11 - Mon, Dec 15
Frontier Logo
6:30 am - 7:03 pmSFO-DSM
10h 33m1 stop
Frontier Logo
7:58 pm - 12:24 amDSM-SFO
6h 26m1 stop
$258Frontier
Find Deal
Mon, Dec 8 - Fri, Dec 12
Multiple Airlines Logo
8:48 am - 7:03 pmSFO-DSM
8h 15m1 stop
Multiple Airlines Logo
8:00 am - 11:07 pmDSM-SFO
17h 07m2 stops
$295Multiple Airlines
Find Deal
Mon, Dec 8 - Wed, Dec 10
Multiple Airlines Logo
9:03 pm - 6:38 pmSFO-DSM
19h 35m2 stops
Multiple Airlines Logo
7:28 pm - 4:51 pmDSM-SFO
23h 23m1 stop
$297Multiple Airlines
Find Deal
Thu, Dec 11 - Mon, Dec 15
Multiple Airlines Logo
9:32 pm - 3:40 pmSFO-DSM
16h 08m1 stop
Multiple Airlines Logo
9:00 am - 2:14 pmDSM-SFO
31h 14m2 stops
$394Multiple Airlines
Find Deal
Sun, Feb 8 - Sat, Feb 14
American Airlines Logo
12:17 am - 10:50 amSFO-DSM
8h 33m1 stop
American Airlines Logo
3:26 pm - 10:04 pmDSM-SFO
8h 38m1 stop
$403American Airlines
Find Deal
Sat, Feb 7 - Sat, Feb 14
American Airlines Logo
12:17 am - 10:50 amSFO-DSM
8h 33m1 stop
American Airlines Logo
11:27 am - 7:14 pmDSM-SFO
9h 47m2 stops
$408American Airlines
Find Deal
Sat, Feb 7 - Sat, Feb 14
Southwest Logo
7:40 am - 7:20 pmSFO-DSM
9h 40m2 stops
Southwest Logo
11:30 am - 7:35 pmDSM-SFO
10h 05m2 stops
$413Southwest
Find Deal
Sun, Feb 8 - Sat, Feb 14

Frontier flights from San Francisco to Des Moines

Our best Frontier deals on San Francisco to Des Moines flight tickets
Frontier
Dec 8
SFO6:30 amSan Francisco
10h 33m
1 stop
DSM7:03 pmDes Moines
Dec 12
DSM7:58 pmDes Moines
6h 26m
1 stop
SFO12:24 amSan Francisco
$232
Find similar
Frontier
Dec 8
SFO6:30 amSan Francisco
10h 33m
1 stop
DSM7:03 pmDes Moines
Dec 12
DSM7:58 pmDes Moines
6h 26m
1 stop
SFO12:24 amSan Francisco
$237
Find similar
Frontier
Dec 11
SFO4:07 pmSan Francisco
24h 56m
1 stop
DSM7:03 pmDes Moines
Dec 15
DSM7:58 pmDes Moines
6h 26m
1 stop
SFO12:24 amSan Francisco
$254
Find similar

American Airlines flights from San Francisco to Des Moines

Our best American Airlines deals on San Francisco to Des Moines flight tickets
American Airlines
Feb 7
SFO12:17 amSan Francisco
8h 33m
1 stop
DSM10:50 amDes Moines
Feb 14
DSM3:26 pmDes Moines
8h 38m
1 stop
SFO10:04 pmSan Francisco
$403
Find similar
American Airlines
Feb 7
SFO12:17 amSan Francisco
8h 33m
1 stop
DSM10:50 amDes Moines
Feb 14
DSM11:27 amDes Moines
9h 47m
2 stops
SFO7:14 pmSan Francisco
$408
Find similar
American Airlines
Dec 17
SFO6:00 amSan Francisco
8h 51m
1 stop
DSM4:51 pmDes Moines
Dec 24
DSM5:21 amDes Moines
9h 00m
1 stop
SFO12:21 pmSan Francisco
$441
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 26, 2025.
Use the filters below to find and compare flights from San Francisco to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 12/8

6:30 am-7:03 pm

1 stop10h 33m

Des Moines

Fri 12/12

7:58 pm-12:24 am

1 stop6h 26m

$232

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 12/8

6:30 am-7:03 pm

1 stop10h 33m

Des Moines

Fri 12/12

7:58 pm-12:24 am

1 stop6h 26m

$237

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 12/11

4:07 pm-7:03 pm

1 stop24h 56m

Des Moines

Mon 12/15

7:58 pm-12:24 am

1 stop6h 26m

$254

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 12/8

6:30 am-7:03 pm

1 stop10h 33m

Des Moines

Fri 12/12

7:58 pm-12:24 am

1 stop6h 26m

$258

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 12/8

8:48 am-7:03 pm

1 stop8h 15m

Des Moines

Wed 12/10

8:00 am-11:07 pm

2 stops17h 07m

$295

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 12/11

9:03 pm-6:38 pm

2 stops19h 35m

Des Moines

Mon 12/15

7:28 pm-4:51 pm

1 stop23h 23m

$297

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Sun 2/8

9:32 pm-3:40 pm

1 stop16h 08m

Des Moines

Sat 2/14

9:00 am-2:14 pm

2 stops31h 14m

$394

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Sat 2/7

12:17 am-10:50 am

1 stop8h 33m

Des Moines

Sat 2/14

3:26 pm-10:04 pm

1 stop8h 38m

$403

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Sat 2/7

12:17 am-10:50 am

1 stop8h 33m

Des Moines

Sat 2/14

11:27 am-7:14 pm

2 stops9h 47m

$408

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Sun 2/8

7:40 am-7:20 pm

2 stops9h 40m

Des Moines

Sat 2/14

11:30 am-7:35 pm

2 stops10h 05m

$413

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from San Francisco to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in September, then January is your next best option. Flight prices from San Francisco to Des Moines during January average around $397.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from San Francisco to Des Moines is on a Wednesday. Travelers who choose to depart for Des Moines on a Wednesday will often find tickets for as low as $397. Flights from San Francisco to Des Moines on a Sunday will generally be more expensive and average around $607. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is at noon. momondo users have found flights departing from San Francisco to Des Moines at noon for as low as $389. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the morning because they tend to be around $511. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest San Francisco to Des Moines flight route?

Fly from San Francisco to Des Moines for the best San Francisco - Des Moines flight prices

How far in advance should I book a flight to Des Moines?

You are more likely to see cheaper flights to Des Moines from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Des Moines for around $466 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Des Moines from San Francisco for as low as $347 on momondo.

What cabin class options are available on San Francisco to Des Moines flights?

There is only 1 cabin class available to choose from on San Francisco to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have San Francisco to Des Moines flight prices changed over time?

As of November 2025, prices for San Francisco to Des Moines flights are approximately 145% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Des Moines (SFO to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Des Moines

Fastest flight time

6h 20m

Direct flights

None
The fastest flight from San Francisco to Des Moines takes 6h 20m
There are no direct flights from San Francisco to Des Moines. There are no popular flight routes from San Francisco to Des Moines.
Search flight deals

  • How far is San Francisco to Des Moines by plane?

    The distance between San Francisco and Des Moines is about 1544.3 mi. A reasonable flight in good conditions will take 5h 42m.

  • When did momondo last update prices for flights from San Francisco Airport to Des Moines Airport?

    Prices for flights from San Francisco Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from San Francisco Airport to Des Moines Airport?

  • How old do you have to be to fly from San Francisco Airport to Des Moines Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Francisco Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Francisco to Des Moines?

Best airlines flying from San Francisco to Des Moines

Compare and see reviews for airlines that fly from San Francisco to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $149Free CancellationRating
5.8
3,099 reviews
Search Frontier flights
DeltaPriceFrom $319Free CancellationRating
7.9
7,999 reviews
Search Delta flights
American AirlinesPriceFrom $341Free CancellationRating
7.2
11,038 reviews
Search American Airlines flights
SouthwestPriceFrom $356Free CancellationRating
8.0
4,254 reviews
Search Southwest flights
United AirlinesPriceFrom $366Free CancellationRating
7.4
9,046 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Urbandale
Clive
Pella
Newton
Johnston
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from San Francisco to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from San Francisco to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from San Francisco on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Francisco to Des Moines?

Once all potential San Francisco to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Francisco to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of San Francisco to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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