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Cheap flights from San Francisco to Des Moines from $128

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Des Moines departing on 7/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from San Francisco to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
11:12 am - 1:31 pm
SFO
-
DSM
24h 19m
2 stops
Frontier Logo
2:16 pm - 11:38 am
DSM
-
SFO
23h 22m
1 stop
$217Frontier
Tue, Aug 25 - Mon, Aug 31
Multiple Airlines Logo
10:50 pm - 9:00 pm
SFO
-
DSM
20h 10m
1 stop
Multiple Airlines Logo
2:16 pm - 11:38 am
DSM
-
SFO
23h 22m
1 stop
$226Multiple Airlines
Wed, Aug 26 - Mon, Aug 31
Multiple Airlines Logo
10:50 pm - 6:48 pm
SFO
-
DSM
17h 58m
1 stop
Multiple Airlines Logo
2:16 pm - 11:38 am
DSM
-
SFO
23h 22m
1 stop
$248Multiple Airlines
Thu, Aug 27 - Mon, Aug 31
Frontier Logo
10:06 pm - 1:31 pm
SFO
-
DSM
37h 25m
2 stops
Frontier Logo
2:16 pm - 11:38 am
DSM
-
SFO
23h 22m
1 stop
$250Frontier
Mon, Aug 24 - Mon, Aug 31
Multiple Airlines Logo
4:30 pm - 8:54 pm
SFO
-
DSM
26h 24m
1 stop
Multiple Airlines Logo
10:06 pm - 10:27 am
DSM
-
SFO
14h 21m
1 stop
$255Multiple Airlines
Wed, Aug 12 - Mon, Aug 17
Multiple Airlines Logo
11:24 am - 9:00 pm
SFO
-
DSM
7h 36m
1 stop
Multiple Airlines Logo
9:50 pm - 7:56 pm
DSM
-
SFO
24h 06m
1 stop
$258Multiple Airlines
Thu, Aug 20 - Sun, Aug 23
Frontier Logo
5:11 pm - 1:31 pm
SFO
-
DSM
18h 20m
2 stops
Frontier Logo
2:16 pm - 11:38 am
DSM
-
SFO
23h 22m
1 stop
$270Frontier
Sun, Aug 23 - Mon, Aug 31
Multiple Airlines Logo
11:24 am - 7:48 pm
SFO
-
DSM
6h 24m
1 stop
Multiple Airlines Logo
2:16 pm - 11:38 am
DSM
-
SFO
23h 22m
1 stop
$273Multiple Airlines
Mon, Aug 24 - Mon, Aug 31
Multiple Airlines Logo
9:00 pm - 12:59 pm
SFO
-
DSM
13h 59m
1 stop
Multiple Airlines Logo
10:01 pm - 9:38 pm
DSM
-
SFO
25h 37m
2 stops
$277Multiple Airlines
Tue, Jul 28 - Mon, Aug 3
Multiple Airlines Logo
5:26 pm - 5:43 pm
SFO
-
DSM
22h 17m
1 stop
Multiple Airlines Logo
2:16 pm - 11:38 am
DSM
-
SFO
23h 22m
1 stop
$280Multiple Airlines
Sat, Aug 22 - Mon, Aug 31

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Southwest flights from San Francisco to Des Moines

Our best Southwest deals on San Francisco to Des Moines flight tickets
Southwest
Oct 14
SFO6:50 amSan Francisco
8h 55m
1 stop
DSM5:45 pmDes Moines
Nov 14
DSM7:00 amDes Moines
9h 30m
2 stops
SFO2:30 pmSan Francisco
$343
Southwest
Jun 23
SFO7:10 amSan Francisco
9h 10m
2 stops
DSM6:20 pmDes Moines
Jun 26
DSM6:10 amDes Moines
8h 50m
2 stops
SFO1:00 pmSan Francisco
$573
Southwest
Jun 19
SFO12:00 pmSan Francisco
8h 20m
2 stops
DSM10:20 pmDes Moines
Jun 23
DSM12:10 pmDes Moines
8h 30m
1 stop
SFO6:40 pmSan Francisco
$592

Frontier flights from San Francisco to Des Moines

Our best Frontier deals on San Francisco to Des Moines flight tickets
Frontier
Aug 25
SFO11:12 amSan Francisco
24h 19m
2 stops
DSM1:31 pmDes Moines
Aug 31
DSM2:16 pmDes Moines
23h 22m
1 stop
SFO11:38 amSan Francisco
$217
Frontier
Aug 24
SFO10:06 pmSan Francisco
37h 25m
2 stops
DSM1:31 pmDes Moines
Aug 31
DSM2:16 pmDes Moines
23h 22m
1 stop
SFO11:38 amSan Francisco
$250
Frontier
Aug 23
SFO5:11 pmSan Francisco
18h 20m
2 stops
DSM1:31 pmDes Moines
Aug 31
DSM2:16 pmDes Moines
23h 22m
1 stop
SFO11:38 amSan Francisco
$270

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 9, 2026.
Use the filters below to find and compare flights from San Francisco to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Tue 8/25

11:12 am-1:31 pm

2 stops24h 19m

Des Moines

Mon 8/31

2:16 pm-11:38 am

1 stop23h 22m

$217

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Wed 8/26

10:50 pm-9:00 pm

1 stop20h 10m

Des Moines

Mon 8/31

2:16 pm-11:38 am

1 stop23h 22m

$226

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 8/27

10:50 pm-6:48 pm

1 stop17h 58m

Des Moines

Mon 8/31

2:16 pm-11:38 am

1 stop23h 22m

$248

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 8/24

10:06 pm-1:31 pm

2 stops37h 25m

Des Moines

Mon 8/31

2:16 pm-11:38 am

1 stop23h 22m

$250

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Wed 8/12

4:30 pm-8:54 pm

1 stop26h 24m

Des Moines

Mon 8/17

10:06 pm-10:27 am

1 stop14h 21m

$255

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 8/20

11:24 am-9:00 pm

1 stop7h 36m

Des Moines

Sun 8/23

9:50 pm-7:56 pm

1 stop24h 06m

$258

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Sun 8/23

5:11 pm-1:31 pm

2 stops18h 20m

Des Moines

Mon 8/31

2:16 pm-11:38 am

1 stop23h 22m

$270
Quickest round-trip

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 8/24

11:24 am-7:48 pm

1 stop6h 24m

Des Moines

Mon 8/31

2:16 pm-11:38 am

1 stop23h 22m

$273

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Tue 7/28

9:00 pm-12:59 pm

1 stop13h 59m

Des Moines

Mon 8/3

10:01 pm-9:38 pm

2 stops25h 37m

$277

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Sat 8/22

5:26 pm-5:43 pm

1 stop22h 17m

Des Moines

Mon 8/31

2:16 pm-11:38 am

1 stop23h 22m

$280

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from San Francisco to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Francisco and Des Moines?

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in February, then September is your next best option. Flight prices from San Francisco to Des Moines during September average around $319.

How far in advance should I book a flight from San Francisco to Des Moines?

You are more likely to see cheaper flights to Des Moines from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Des Moines for around $551 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Des Moines from San Francisco for as low as $312 on momondo.

How have San Francisco to Des Moines flight prices changed over time?

As of June 2026, prices for San Francisco to Des Moines flights are approximately 48% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Des Moines (SFO to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Des Moines

Fastest flight time

5h 15m

Direct flights

None
The fastest flight from San Francisco to Des Moines takes 5h 15m
There are no direct flights from San Francisco to Des Moines. There are no popular flight routes from San Francisco to Des Moines.
Search flight deals

Frequently asked questions about flying from San Francisco to Des Moines

  • How far is San Francisco to Des Moines by plane?

    The distance between San Francisco and Des Moines is about 1543.9 mi. A reasonable flight in good conditions will take 5h 15m.

  • When did momondo last update prices for flights from San Francisco Airport to Des Moines Airport?

    Prices for flights from San Francisco Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from San Francisco Airport to Des Moines Airport?

  • How old do you have to be to fly from San Francisco Airport to Des Moines Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Francisco Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Francisco to Des Moines?

Best airlines flying from San Francisco to Des Moines

Compare and see reviews for airlines that fly from San Francisco to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $149Free CancellationRating
5.6
2,902 reviews
Search Frontier flights
DeltaPriceFrom $319Free CancellationRating
7.9
8,394 reviews
Search Delta flights
American AirlinesPriceFrom $341Free CancellationRating
7.1
11,640 reviews
Search American Airlines flights
SouthwestPriceFrom $346Free CancellationRating
7.9
4,240 reviews
Search Southwest flights
United AirlinesPriceFrom $406Free CancellationRating
7.4
9,796 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Pella
Urbandale
Osceola
Johnston
Newton
Boone
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from San Francisco to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from San Francisco to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from San Francisco on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Francisco to Des Moines?

Once all potential San Francisco to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Francisco to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of San Francisco to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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