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Cheap flights from San Francisco to Des Moines from $71

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Des Moines departing on 12/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Francisco to Des Moines

Cheap round-trip flights

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Frontier Logo
6:30 am - 7:03 pmSFO-DSM
10h 33m1 stop
Frontier Logo
7:58 pm - 12:24 amDSM-SFO
6h 26m1 stop
$134Frontier
Find Deal
Mon, Dec 8 - Fri, Dec 12
Frontier Logo
8:48 am - 7:03 pmSFO-DSM
8h 15m1 stop
Frontier Logo
7:58 pm - 12:24 amDSM-SFO
6h 26m1 stop
$138Frontier
Find Deal
Mon, Dec 8 - Fri, Dec 12
American Airlines Logo
12:25 am - 1:19 pmSFO-DSM
10h 54m1 stop
American Airlines Logo
5:21 am - 7:14 pmDSM-SFO
15h 53m1 stop
$372American Airlines
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Wed, Dec 3 - Sat, Dec 6
Delta Logo
11:56 am - 9:15 pmSFO-DSM
7h 19m1 stop
Delta Logo
2:59 pm - 8:28 pmDSM-SFO
7h 29m1 stop
$377Delta
Find Deal
Thu, Dec 4 - Wed, Dec 10
Southwest Logo
9:25 am - 7:55 pmSFO-DSM
8h 30m2 stops
Southwest Logo
5:25 am - 9:30 amDSM-SFO
6h 05m1 stop
$387Southwest
Find Deal
Thu, Dec 4 - Sat, Dec 6
American Airlines Logo
12:25 am - 1:19 pmSFO-DSM
10h 54m1 stop
American Airlines Logo
5:10 am - 4:07 pmDSM-SFO
12h 57m1 stop
$390American Airlines
Find Deal
Wed, Dec 3 - Sun, Dec 7
Southwest Logo
7:25 am - 7:55 pmSFO-DSM
10h 30m2 stops
Southwest Logo
5:25 am - 1:40 pmDSM-SFO
10h 15m2 stops
$392Southwest
Find Deal
Thu, Dec 4 - Sat, Dec 6
Delta Logo
12:30 am - 10:21 amSFO-DSM
7h 51m1 stop
Delta Logo
11:01 am - 6:04 pmDSM-SFO
9h 03m1 stop
$417Delta
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Sun, Dec 7 - Fri, Dec 12
United Airlines Logo
6:00 am - 2:20 pmSFO-DSM
6h 20m1 stop
United Airlines Logo
5:15 pm - 10:56 pmDSM-SFO
7h 41m1 stop
$451United Airlines
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Thu, Dec 4 - Mon, Dec 8
United Airlines Logo
4:28 pm - 11:44 pmSFO-DSM
5h 16m1 stop
United Airlines Logo
6:05 am - 2:51 pmDSM-SFO
10h 46m1 stop
$528United Airlines
Find Deal
Sat, Nov 22 - Thu, Nov 27

American Airlines flights from San Francisco to Des Moines

Our best American Airlines deals on San Francisco to Des Moines flight tickets
American Airlines
Dec 3
SFO12:25 amSan Francisco
10h 54m
1 stop
DSM1:19 pmDes Moines
Dec 6
DSM5:21 amDes Moines
15h 53m
1 stop
SFO7:14 pmSan Francisco
$372
Find similar
American Airlines
Dec 3
SFO12:25 amSan Francisco
10h 54m
1 stop
DSM1:19 pmDes Moines
Dec 7
DSM5:10 amDes Moines
12h 57m
1 stop
SFO4:07 pmSan Francisco
$390
Find similar
American Airlines
Dec 22
SFO10:49 pmSan Francisco
7h 26m
1 stop
DSM8:15 amDes Moines
Jan 7
DSM5:24 amDes Moines
13h 10m
1 stop
SFO4:34 pmSan Francisco
$433
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Delta flights from San Francisco to Des Moines

Our best Delta deals on San Francisco to Des Moines flight tickets
Delta
Dec 4
SFO11:56 amSan Francisco
7h 19m
1 stop
DSM9:15 pmDes Moines
Dec 10
DSM2:59 pmDes Moines
7h 29m
1 stop
SFO8:28 pmSan Francisco
$377
Find similar
Delta
Dec 7
SFO12:30 amSan Francisco
7h 51m
1 stop
DSM10:21 amDes Moines
Dec 12
DSM11:01 amDes Moines
9h 03m
1 stop
SFO6:04 pmSan Francisco
$417
Find similar
Delta
Dec 7
SFO12:30 amSan Francisco
7h 51m
1 stop
DSM10:21 amDes Moines
Dec 12
DSM11:01 amDes Moines
13h 30m
2 stops
SFO10:31 pmSan Francisco
$455
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from San Francisco to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 12/8

6:30 am-7:03 pm

1 stop10h 33m

Des Moines

Fri 12/12

7:58 pm-12:24 am

1 stop6h 26m

$134

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 12/8

8:48 am-7:03 pm

1 stop8h 15m

Des Moines

Fri 12/12

7:58 pm-12:24 am

1 stop6h 26m

$138

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Wed 12/3

12:25 am-1:19 pm

1 stop10h 54m

Des Moines

Sat 12/6

5:21 am-7:14 pm

1 stop15h 53m

$372

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 12/4

11:56 am-9:15 pm

1 stop7h 19m

Des Moines

Wed 12/10

2:59 pm-8:28 pm

1 stop7h 29m

$377

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 12/4

9:25 am-7:55 pm

2 stops8h 30m

Des Moines

Sat 12/6

5:25 am-9:30 am

1 stop6h 05m

$387

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Wed 12/3

12:25 am-1:19 pm

1 stop10h 54m

Des Moines

Sun 12/7

5:10 am-4:07 pm

1 stop12h 57m

$390

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 12/4

7:25 am-7:55 pm

2 stops10h 30m

Des Moines

Sat 12/6

5:25 am-1:40 pm

2 stops10h 15m

$392

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Sun 12/7

12:30 am-10:21 am

1 stop7h 51m

Des Moines

Fri 12/12

11:01 am-6:04 pm

1 stop9h 03m

$417

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 12/4

6:00 am-2:20 pm

1 stop6h 20m

Des Moines

Mon 12/8

5:15 pm-10:56 pm

1 stop7h 41m

$451

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Sat 11/22

4:28 pm-11:44 pm

1 stop5h 16m

Des Moines

Thu 11/27

6:05 am-2:51 pm

1 stop10h 46m

$528

Flights are sorted by cheapest round-trip flights first.

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See travel insights to Des Moines from

How to get the cheapest flight ticket from San Francisco to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in September, then January is your next best option. Flight prices from San Francisco to Des Moines during January average around $397.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from San Francisco to Des Moines is on a Wednesday. Travelers who choose to depart for Des Moines on a Wednesday will often find tickets for as low as $397. Flights from San Francisco to Des Moines on a Sunday will generally be more expensive and average around $607. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is at noon. momondo users have found flights departing from San Francisco to Des Moines at noon for as low as $389. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the morning because they tend to be around $511. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest San Francisco to Des Moines flight route?

Fly from San Francisco to Des Moines for the best San Francisco - Des Moines flight prices

How far in advance should I book a flight to Des Moines?

You are more likely to see cheaper flights to Des Moines from San Francisco when booking weeks ahead of your departure date. In general, you can expect to find flights to Des Moines for around $464 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Des Moines from San Francisco for as low as $361 on momondo.

What cabin class options are available on San Francisco to Des Moines flights?

There is only 1 cabin class available to choose from on San Francisco to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have San Francisco to Des Moines flight prices changed over time?

As of November 2025, prices for San Francisco to Des Moines flights are approximately 146% more expensive when compared to flights at the same time last year.

When to book flights from San Francisco to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Des Moines (SFO to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Des Moines

Direct flights

None
There are no direct flights from San Francisco to Des Moines. There are no popular flight routes from San Francisco to Des Moines.
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  • How far is San Francisco to Des Moines by plane?

    The distance between San Francisco and Des Moines is about 1544.3 mi. A reasonable flight in good conditions will take 5h 13m.

  • When did momondo last update prices for flights from San Francisco Airport to Des Moines Airport?

    Prices for flights from San Francisco Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from San Francisco Airport to Des Moines Airport?

  • How old do you have to be to fly from San Francisco Airport to Des Moines Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Francisco Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Francisco to Des Moines?

Best airlines flying from San Francisco to Des Moines

Compare and see reviews for airlines that fly from San Francisco to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $149Free CancellationRating
5.8
3,115 reviews
Search Frontier flights
DeltaPriceFrom $319Free CancellationRating
7.9
8,001 reviews
Search Delta flights
American AirlinesPriceFrom $341Free CancellationRating
7.2
11,040 reviews
Search American Airlines flights
SouthwestPriceFrom $356Free CancellationRating
8.0
4,241 reviews
Search Southwest flights
United AirlinesPriceFrom $366Free CancellationRating
7.4
9,007 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Urbandale
Clive
Newton
Pella
Johnston
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from San Francisco to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from San Francisco to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from San Francisco on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Francisco to Des Moines?

Once all potential San Francisco to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Francisco to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of San Francisco to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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