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Cheap flights from San Francisco to Des Moines from $103

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Francisco to Des Moines departing on 8/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from San Francisco to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
11:42 am - 9:06 pm
SFO
-
DSM
7h 24m
1 stop
Multiple Airlines Logo
9:31 pm - 10:46 am
DSM
-
SFO
15h 15m
1 stop
$181Multiple Airlines
Thu, Sep 10 - Mon, Sep 14
Multiple Airlines Logo
11:42 am - 1:52 pm
SFO
-
DSM
24h 10m
1 stop
Multiple Airlines Logo
2:42 pm - 5:49 pm
DSM
-
SFO
29h 07m
1 stop
$205Multiple Airlines
Tue, Sep 29 - Wed, Oct 7
Multiple Airlines Logo
11:42 am - 9:06 pm
SFO
-
DSM
7h 24m
1 stop
Multiple Airlines Logo
2:51 pm - 10:46 am
DSM
-
SFO
21h 55m
2 stops
$214Multiple Airlines
Thu, Sep 10 - Mon, Sep 14
Multiple Airlines Logo
11:42 am - 9:06 pm
SFO
-
DSM
7h 24m
1 stop
Multiple Airlines Logo
9:56 pm - 8:23 am
DSM
-
SFO
12h 27m
1 stop
$236Multiple Airlines
Thu, Sep 10 - Sun, Sep 13
Multiple Airlines Logo
11:42 am - 9:06 pm
SFO
-
DSM
7h 24m
1 stop
Multiple Airlines Logo
9:56 pm - 11:45 pm
DSM
-
SFO
27h 49m
1 stop
$238Multiple Airlines
Thu, Sep 10 - Sun, Sep 13
Delta Logo
10:59 pm - 9:33 am
SFO
-
DSM
8h 34m
1 stop
Delta Logo
5:59 pm - 11:53 pm
DSM
-
SFO
7h 54m
1 stop
$251Delta
Fri, Sep 25 - Thu, Oct 1
Multiple Airlines Logo
6:30 am - 9:06 pm
SFO
-
DSM
12h 36m
1 stop
Multiple Airlines Logo
9:56 pm - 8:32 pm
DSM
-
SFO
24h 36m
2 stops
$257Multiple Airlines
Thu, Sep 10 - Sun, Sep 13
Southwest Logo
6:45 am - 6:30 pm
SFO
-
DSM
9h 45m
1 stop
Southwest Logo
2:00 pm - 12:35 am
DSM
-
SFO
12h 35m
1 stop
$262Southwest
Thu, Oct 8 - Mon, Oct 12
Multiple Airlines Logo
7:30 pm - 1:52 pm
SFO
-
DSM
40h 22m
2 stops
Multiple Airlines Logo
2:42 pm - 8:23 am
DSM
-
SFO
19h 41m
1 stop
$265Multiple Airlines
Mon, Sep 28 - Wed, Oct 7
Multiple Airlines Logo
10:07 pm - 8:54 pm
SFO
-
DSM
20h 47m
1 stop
Multiple Airlines Logo
9:44 pm - 8:10 pm
DSM
-
SFO
24h 26m
1 stop
$268Multiple Airlines
Wed, Aug 12 - Sun, Aug 16

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Southwest flights from San Francisco to Des Moines

Our best Southwest deals on San Francisco to Des Moines flight tickets
Southwest
Oct 8
SFO6:45 amSan Francisco
9h 45m
1 stop
DSM6:30 pmDes Moines
Oct 12
DSM2:00 pmDes Moines
12h 35m
1 stop
SFO12:35 amSan Francisco
$262
Southwest
Aug 19
SFO10:40 amSan Francisco
8h 20m
2 stops
DSM9:00 pmDes Moines
Aug 26
DSM7:15 amDes Moines
7h 20m
2 stops
SFO12:35 pmSan Francisco
$285
Southwest
Aug 8
SFO5:00 amSan Francisco
9h 10m
1 stop
DSM4:10 pmDes Moines
Aug 14
DSM2:25 pmDes Moines
9h 05m
2 stops
SFO9:30 pmSan Francisco
$286

United Airlines flights from San Francisco to Des Moines

Our best United Airlines deals on San Francisco to Des Moines flight tickets
United Airlines
Aug 28
SFO12:55 amSan Francisco
7h 31m
1 stop
DSM10:26 amDes Moines
Sep 2
DSM11:32 amDes Moines
9h 17m
1 stop
SFO6:49 pmSan Francisco
$351
United Airlines
Aug 28
SFO12:45 amSan Francisco
11h 31m
2 stops
DSM2:16 pmDes Moines
Sep 2
DSM1:21 pmDes Moines
7h 56m
1 stop
SFO7:17 pmSan Francisco
$356
United Airlines
Aug 29
SFO4:18 pmSan Francisco
5h 26m
1 stop
DSM11:44 pmDes Moines
Sep 2
DSM1:21 pmDes Moines
9h 49m
1 stop
SFO9:10 pmSan Francisco
$401

momondo Fare Finder

 
Customize your flight search to find flights from San Francisco to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 13, 2026.
Use the filters below to find and compare flights from San Francisco to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 9/10

11:42 am-9:06 pm

1 stop7h 24m

Des Moines

Mon 9/14

9:31 pm-10:46 am

1 stop15h 15m

$181

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Tue 9/29

11:42 am-1:52 pm

1 stop24h 10m

Des Moines

Wed 10/7

2:42 pm-5:49 pm

1 stop29h 07m

$205

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 9/10

11:42 am-9:06 pm

1 stop7h 24m

Des Moines

Mon 9/14

2:51 pm-10:46 am

2 stops21h 55m

$214

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 9/10

11:42 am-9:06 pm

1 stop7h 24m

Des Moines

Sun 9/13

9:56 pm-8:23 am

1 stop12h 27m

$236

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 9/10

11:42 am-9:06 pm

1 stop7h 24m

Des Moines

Sun 9/13

9:56 pm-11:45 pm

1 stop27h 49m

$238
Quickest round-trip

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Fri 9/25

10:59 pm-9:33 am

1 stop8h 34m

Des Moines

Thu 10/1

5:59 pm-11:53 pm

1 stop7h 54m

$251

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 9/10

6:30 am-9:06 pm

1 stop12h 36m

Des Moines

Sun 9/13

9:56 pm-8:32 pm

2 stops24h 36m

$257

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 10/8

6:45 am-6:30 pm

1 stop9h 45m

Des Moines

Mon 10/12

2:00 pm-12:35 am

1 stop12h 35m

$262

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 9/28

7:30 pm-1:52 pm

2 stops40h 22m

Des Moines

Wed 10/7

2:42 pm-8:23 am

1 stop19h 41m

$265

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Wed 8/12

10:07 pm-8:54 pm

1 stop20h 47m

Des Moines

Sun 8/16

9:44 pm-8:10 pm

1 stop24h 26m

$268

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from San Francisco to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Francisco and Des Moines?

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in February, then September is your next best option. Flight prices from San Francisco to Des Moines during September average around $319.

How have San Francisco to Des Moines flight prices changed over time?

As of July 2026, prices for San Francisco to Des Moines flights are approximately 40% cheaper when compared to flights at the same time last year.

When to book flights from San Francisco to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from San Francisco to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Francisco to Des Moines (SFO to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Francisco to Des Moines

Fastest flight time

5h 34m

Direct flights

None
The fastest flight from San Francisco to Des Moines takes 5h 34m
There are no direct flights from San Francisco to Des Moines. There are no popular flight routes from San Francisco to Des Moines.
Search flight deals

Frequently asked questions about flying from San Francisco to Des Moines

  • How far is San Francisco to Des Moines by plane?

    The distance between San Francisco and Des Moines is about 1543.9 mi. A reasonable flight in good conditions will take 5h 34m.

  • When did momondo last update prices for flights from San Francisco Airport to Des Moines Airport?

    Prices for flights from San Francisco Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from San Francisco Airport to Des Moines Airport?

  • How old do you have to be to fly from San Francisco Airport to Des Moines Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Francisco Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from San Francisco to Des Moines?

Best airlines flying from San Francisco to Des Moines

Compare and see reviews for airlines that fly from San Francisco to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $149Free CancellationRating
5.6
2,815 reviews
Search Frontier flights
DeltaPriceFrom $319Free CancellationRating
7.8
8,464 reviews
Search Delta flights
American AirlinesPriceFrom $345Free CancellationRating
7.1
11,810 reviews
Search American Airlines flights
United AirlinesPriceFrom $366Free CancellationRating
7.4
9,983 reviews
Search United Airlines flights
SouthwestPriceFrom $374Free CancellationRating
8.0
4,249 reviews
Search Southwest flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Clive
Altoona
Pella
Urbandale
Osceola
Johnston
Newton
Boone
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from San Francisco to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from San Francisco to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from San Francisco to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from San Francisco on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Francisco to Des Moines?

Once all potential San Francisco to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Francisco to Des Moines right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of San Francisco to Des Moines flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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