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Cheap flights from San Diego to St. Louis from $61

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to St. Louis departing on 2/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Diego to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
7:11 am - 3:53 pm
SAN
-
STL
6h 42m
1 stop
Frontier Logo
2:51 pm - 12:08 am
STL
-
SAN
11h 17m
1 stop
$126Frontier
Wed, Feb 25 - Sat, Feb 28
Frontier Logo
7:11 am - 3:53 pm
SAN
-
STL
6h 42m
1 stop
Frontier Logo
2:51 pm - 12:08 am
STL
-
SAN
11h 17m
1 stop
$148Frontier
Wed, Feb 25 - Sat, Feb 28
Frontier Logo
9:18 pm - 9:49 am
SAN
-
STL
10h 31m
1 stop
Frontier Logo
9:22 pm - 4:13 pm
STL
-
SAN
20h 51m
1 stop
$151Frontier
Fri, Mar 6 - Sun, Mar 8
Frontier Logo
6:25 am - 1:09 pm
SAN
-
STL
28h 44m
1 stop
Frontier Logo
8:47 pm - 8:24 pm
STL
-
SAN
25h 37m
1 stop
$156Frontier
Thu, Feb 19 - Mon, Feb 23
Frontier Logo
6:25 am - 1:56 pm
SAN
-
STL
29h 31m
1 stop
Frontier Logo
2:51 pm - 12:08 am
STL
-
SAN
11h 17m
1 stop
$160Frontier
Fri, Feb 13 - Sat, Feb 21
Frontier Logo
6:25 am - 1:56 pm
SAN
-
STL
5h 31m
1 stop
Frontier Logo
2:51 pm - 12:08 am
STL
-
SAN
11h 17m
1 stop
$164Frontier
Sat, Feb 14 - Sat, Feb 21
Frontier Logo
2:38 pm - 11:19 am
SAN
-
STL
18h 41m
1 stop
Frontier Logo
8:12 pm - 12:09 am
STL
-
SAN
29h 57m
1 stop
$172Frontier
Thu, Mar 5 - Mon, Mar 9
Frontier Logo
7:11 am - 3:53 pm
SAN
-
STL
6h 42m
1 stop
Frontier Logo
2:51 pm - 1:57 pm
STL
-
SAN
25h 06m
2 stops
$174Frontier
Wed, Feb 25 - Sat, Feb 28
Frontier Logo
7:00 am - 2:46 pm
SAN
-
STL
5h 46m
1 stop
Frontier Logo
3:46 pm - 11:31 pm
STL
-
SAN
9h 45m
1 stop
$180Frontier
Wed, Feb 4 - Sat, Feb 7
Frontier Logo
8:00 am - 6:51 am
SAN
-
STL
44h 51m
2 stops
Frontier Logo
2:51 pm - 8:24 am
STL
-
SAN
19h 33m
1 stop
$181Frontier
Sat, Feb 14 - Sat, Feb 21

Frontier flights from San Diego to St. Louis

Our best Frontier deals on San Diego to St. Louis flight tickets
Frontier
Feb 25
SAN7:11 amSan Diego
6h 42m
1 stop
STL3:53 pmLambert-St Louis
Feb 28
STL2:51 pmLambert-St Louis
11h 17m
1 stop
SAN12:08 amSan Diego
$126
Frontier
Feb 25
SAN7:11 amSan Diego
6h 42m
1 stop
STL3:53 pmLambert-St Louis
Feb 28
STL2:51 pmLambert-St Louis
11h 17m
1 stop
SAN12:08 amSan Diego
$148
Frontier
Mar 6
SAN9:18 pmSan Diego
10h 31m
1 stop
STL9:49 amLambert-St Louis
Mar 8
STL9:22 pmLambert-St Louis
20h 51m
1 stop
SAN4:13 pmSan Diego
$151

Alaska Airlines flights from San Diego to St. Louis

Our best Alaska Airlines deals on San Diego to St. Louis flight tickets
Alaska Airlines
Feb 18
SAN8:26 pmSan Diego
15h 25m
1 stop
STL1:51 pmLambert-St Louis
Feb 24
STL7:00 amLambert-St Louis
10h 46m
1 stop
SAN3:46 pmSan Diego
$257
Alaska Airlines
Mar 6
SAN12:05 pmSan Diego
9h 54m
1 stop
STL11:59 pmLambert-St Louis
Mar 8
STL7:00 amLambert-St Louis
10h 46m
1 stop
SAN3:46 pmSan Diego
$289

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 21, 2026.
Use the filters below to find and compare flights from San Diego to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Wed 2/25

7:11 am-3:53 pm

1 stop6h 42m

Lambert-St Louis

Sat 2/28

2:51 pm-12:08 am

1 stop11h 17m

$126

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Wed 2/25

7:11 am-3:53 pm

1 stop6h 42m

Lambert-St Louis

Sat 2/28

2:51 pm-12:08 am

1 stop11h 17m

$148

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Fri 3/6

9:18 pm-9:49 am

1 stop10h 31m

Lambert-St Louis

Sun 3/8

9:22 pm-4:13 pm

1 stop20h 51m

$151

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Thu 2/19

6:25 am-1:09 pm

1 stop28h 44m

Lambert-St Louis

Mon 2/23

8:47 pm-8:24 pm

1 stop25h 37m

$156

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Fri 2/13

6:25 am-1:56 pm

1 stop29h 31m

Lambert-St Louis

Sat 2/21

2:51 pm-12:08 am

1 stop11h 17m

$160

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Sat 2/14

6:25 am-1:56 pm

1 stop5h 31m

Lambert-St Louis

Sat 2/21

2:51 pm-12:08 am

1 stop11h 17m

$164

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Thu 3/5

2:38 pm-11:19 am

1 stop18h 41m

Lambert-St Louis

Mon 3/9

8:12 pm-12:09 am

1 stop29h 57m

$172

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Wed 2/25

7:11 am-3:53 pm

1 stop6h 42m

Lambert-St Louis

Sat 2/28

2:51 pm-1:57 pm

2 stops25h 06m

$174

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Wed 2/4

7:00 am-2:46 pm

1 stop5h 46m

Lambert-St Louis

Sat 2/7

3:46 pm-11:31 pm

1 stop9h 45m

$180

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Sat 2/14

8:00 am-6:51 am

2 stops44h 51m

Lambert-St Louis

Sat 2/21

2:51 pm-8:24 am

1 stop19h 33m

$181

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from San Diego to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, September is the cheapest month to fly from San Diego to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $271. The month of February is another great option to travel to St. Louis, with average flight prices from San Diego averaging around $335.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Thursday when prices can be found for as low as $429. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $572. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from San Diego at noon is the least expensive time of day to depart. momondo users have found prices as low as $463 when looking at flights departing at noon. In the afternoon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $485 per ticket.

What is the cheapest San Diego to Lambert-St Louis flight route?

Fly from San Diego to Lambert-St Louis for the best San Diego - Lambert-St Louis flight prices

How far in advance should I book a flight to St. Louis?

You are more likely to see cheaper flights to St. Louis from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $387 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from San Diego for as low as $306 on momondo.

What cabin class options are available on San Diego to Lambert-St Louis flights?

There is only 1 cabin class available to choose from on San Diego to Lambert-St Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on San Diego to St. Louis flights?

You could potentially save up to 26% on your flight if you consider stops on a San Diego to St. Louis flight.

How have San Diego to St. Louis flight prices changed over time?

As of January 2026, prices for San Diego to St. Louis flights are approximately 30% cheaper when compared to flights at the same time last year.

When to book flights from San Diego to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to St. Louis (SAN to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to St. Louis

Best Price Found

$218

Fastest flight time

3h 30m

Direct flights

Every day

Airports in St. Louis

1 airport
The best one-way flight to St. Louis from San Diego in the past 72 hours is $218. The best round-trip flight deal from San Diego to St. Louis found on momondo in the last 72 hours is $408.
The fastest flight from San Diego to St. Louis takes 3h 30m
Direct flights go from San Diego to St. Louis every day.
There is 1 airport in St. Louis. From San Diego there are direct flights to Lambert-St Louis (STL).
Search flight deals

  • How far is San Diego to Lambert-St Louis by plane?

    Lambert-St Louis is 1560.0 mi away from San Diego. 3h 30m is a normal flight duration for this route.

  • When did momondo last update prices for flights from San Diego Airport to Lambert-St Louis Airport?

    Prices for flights from San Diego Airport to Lambert-St Louis Airport refresh daily.

  • How many operators does momondo search for flights from San Diego Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from San Diego Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from San Diego Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents you'll need for your trip to Lambert-St Louis Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Lambert-St Louis Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from San Diego to St. Louis?

  • What is the most popular airline from San Diego to St. Louis?

Best airlines flying from San Diego to St. Louis

Compare and see reviews for airlines that fly from San Diego to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $140Free CancellationRating
5.7
3,057 reviews
Search Frontier flights
DeltaPriceFrom $148Free CancellationRating
7.9
8,089 reviews
Search Delta flights
American AirlinesPriceFrom $249Free CancellationRating
7.2
11,174 reviews
Search American Airlines flights
United AirlinesPriceFrom $256Free CancellationRating
7.4
9,191 reviews
Search United Airlines flights
SouthwestPriceFrom $306Free CancellationRating
8.0
4,266 reviews
Search Southwest flights

  • Southwest Flights From San Diego to St. Louis

    Southwest is one of the most popular airlines flying from San Diego to St. Louis, operating 7 flights/week on average for this route. A good Southwest flight deal for San Diego to St. Louis starts from $306 round-trip, up to an average price of $481. Our users have rated Southwest at 8.0/10.

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
Florissant
O'Fallon
Fenton
Collinsville
St. Peters
Wentzville
Alton
Farmington
Clayton
Eureka
Edwardsville
Festus
Glencoe
Litchfield
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to St. Louis?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from San Diego to St. Louis. momondo saves you time and could save you money on your trip.

Can I find flights from San Diego to St. Louis with flexible booking policies on momondo?

Flights from San Diego to St. Louis with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Diego to St. Louis?

Once all potential San Diego to St. Louis flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Diego to St. Louis right now. Can momondo alert me if prices change?

If you are not ready to book a flight from San Diego to St. Louis now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to St. Louis and let you know when they change.

An easier way to manage your St. Louis trip

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