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Cheap flights from San Diego to St. Louis from $71

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to St. Louis departing on 9/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from San Diego to St. Louis

Cheap round-trip flights

Frontier Logo
6:25 am - 1:53 pmSAN-STL
5h 28m1 stop
Frontier Logo
10:39 am - 4:42 pmSTL-SAN
8h 03m1 stop
$144Frontier
Find Deal
Thu, Sep 4 - Sun, Sep 7
Frontier Logo
9:03 pm - 9:06 amSAN-STL
10h 03m1 stop
Frontier Logo
7:55 pm - 11:53 pmSTL-SAN
5h 58m1 stop
$146Frontier
Find Deal
Thu, Sep 18 - Mon, Sep 22
Frontier Logo
9:03 pm - 9:07 amSAN-STL
10h 04m1 stop
Frontier Logo
10:17 am - 6:28 pmSTL-SAN
10h 11m1 stop
$150Frontier
Find Deal
Fri, Oct 24 - Sun, Oct 26
Frontier Logo
9:03 pm - 9:06 amSAN-STL
10h 03m1 stop
Frontier Logo
7:55 pm - 11:53 pmSTL-SAN
5h 58m1 stop
$151Frontier
Find Deal
Thu, Sep 18 - Mon, Sep 22
Logo
6:15 am - 9:06 amSAN-STL
24h 51m2 stops
Logo
7:55 pm - 10:24 pmSTL-SAN
28h 29m1 stop
$245
Find Deal
Tue, Sep 16 - Fri, Sep 19
Delta Logo
6:15 am - 2:44 pmSAN-STL
6h 29m1 stop
Delta Logo
7:00 pm - 11:44 pmSTL-SAN
6h 44m1 stop
$287Delta
Find Deal
Tue, Sep 30 - Tue, Sep 30
Southwest Logo
8:40 am - 2:20 pmSAN-STL
3h 40mnonstop
Southwest Logo
6:30 pm - 11:05 pmSTL-SAN
6h 35m1 stop
$292Southwest
Find Deal
Tue, Oct 28 - Thu, Oct 30
Southwest Logo
2:35 pm - 9:50 pmSAN-STL
5h 15m1 stop
Southwest Logo
4:25 pm - 6:20 pmSTL-SAN
3h 55mnonstop
$297Southwest
Find Deal
Tue, Sep 30 - Thu, Oct 2
Logo
8:45 pm - 3:18 pmSAN-STL
16h 33m2 stops
Logo
7:45 pm - 11:50 pmSTL-SAN
6h 05m1 stop
$298
Find Deal
Sat, Nov 8 - Tue, Nov 11
Delta Logo
5:05 pm - 12:38 amSAN-STL
5h 33m1 stop
Delta Logo
7:00 pm - 11:44 pmSTL-SAN
6h 44m1 stop
$302Delta
Find Deal
Wed, Sep 17 - Mon, Sep 22

Frontier flights from San Diego to St. Louis

Our best Frontier deals on San Diego to St. Louis flight tickets
Frontier
Sep 4
SAN6:25 amSan Diego
5h 28m
1 stop
STL1:53 pmLambert-St Louis
Sep 7
STL10:39 amLambert-St Louis
8h 03m
1 stop
SAN4:42 pmSan Diego
$144
Find similar
Frontier
Sep 18
SAN9:03 pmSan Diego
10h 03m
1 stop
STL9:06 amLambert-St Louis
Sep 22
STL7:55 pmLambert-St Louis
5h 58m
1 stop
SAN11:53 pmSan Diego
$146
Find similar
Frontier
Oct 24
SAN9:03 pmSan Diego
10h 04m
1 stop
STL9:07 amLambert-St Louis
Oct 26
STL10:17 amLambert-St Louis
10h 11m
1 stop
SAN6:28 pmSan Diego
$150
Find similar

Delta flights from San Diego to St. Louis

Our best Delta deals on San Diego to St. Louis flight tickets
Delta
Sep 30
SAN6:15 amSan Diego
6h 29m
1 stop
STL2:44 pmLambert-St Louis
Sep 30
STL7:00 pmLambert-St Louis
6h 44m
1 stop
SAN11:44 pmSan Diego
$287
Find similar
Delta
Sep 17
SAN5:05 pmSan Diego
5h 33m
1 stop
STL12:38 amLambert-St Louis
Sep 22
STL7:00 pmLambert-St Louis
6h 44m
1 stop
SAN11:44 pmSan Diego
$302
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 25, 2025.
Use the filters below to find and compare flights from San Diego to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Thu 9/4

6:25 am-1:53 pm

1 stop5h 28m

Lambert-St Louis

Sun 9/7

10:39 am-4:42 pm

1 stop8h 03m

$144

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Thu 9/18

9:03 pm-9:06 am

1 stop10h 03m

Lambert-St Louis

Mon 9/22

7:55 pm-11:53 pm

1 stop5h 58m

$146

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Fri 10/24

9:03 pm-9:07 am

1 stop10h 04m

Lambert-St Louis

Sun 10/26

10:17 am-6:28 pm

1 stop10h 11m

$150

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Thu 9/18

9:03 pm-9:06 am

1 stop10h 03m

Lambert-St Louis

Mon 9/22

7:55 pm-11:53 pm

1 stop5h 58m

$151

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Tue 9/16

6:15 am-9:06 am

2 stops24h 51m

Lambert-St Louis

Fri 9/19

7:55 pm-10:24 pm

1 stop28h 29m

$245

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Tue 9/30

6:15 am-2:44 pm

1 stop6h 29m

Lambert-St Louis

Tue 9/30

7:00 pm-11:44 pm

1 stop6h 44m

$287

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Tue 10/28

8:40 am-2:20 pm

Nonstop3h 40m

Lambert-St Louis

Thu 10/30

6:30 pm-11:05 pm

1 stop6h 35m

$292

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Tue 9/30

2:35 pm-9:50 pm

1 stop5h 15m

Lambert-St Louis

Thu 10/2

4:25 pm-6:20 pm

Nonstop3h 55m

$297

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Sat 11/8

8:45 pm-3:18 pm

2 stops16h 33m

Lambert-St Louis

Tue 11/11

7:45 pm-11:50 pm

1 stop6h 05m

$298

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Wed 9/17

5:05 pm-12:38 am

1 stop5h 33m

Lambert-St Louis

Mon 9/22

7:00 pm-11:44 pm

1 stop6h 44m

$302

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from San Diego to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, February is the cheapest month to fly from San Diego to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $310. The month of September is another great option to travel to St. Louis, with average flight prices from San Diego averaging around $313.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Thursday when prices can be found for as low as $454. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $533. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from San Diego in the evening is the least expensive time of day to depart. momondo users have found prices as low as $198 when looking at flights departing in the evening. At noon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $552 per ticket.

What is the cheapest San Diego to Lambert-St Louis flight route?

Fly from San Diego to Lambert-St Louis for the best San Diego - Lambert-St Louis flight prices

How far in advance should I book a flight to St. Louis?

You are more likely to see cheaper flights to St. Louis from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $374 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from San Diego for as low as $275 on momondo.

What cabin class options are available on San Diego to Lambert-St Louis flights?

There are 1 cabin classes available to choose from on San Diego to Lambert-St Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on San Diego to St. Louis flights?

You could potentially save up to 13% on your flight if you consider stops on a San Diego to St. Louis flight.

How have San Diego to St. Louis flight prices changed over time?

As of August 2025, prices for San Diego to St. Louis flights are approximately 4% more expensive when compared to flights at the same time last year.

When to book flights from San Diego to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to St. Louis (SAN to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to St. Louis

Best Price Found

$204

Fastest flight time

3h 30m

Direct flights

Every day

Airports in St. Louis

1 airport
The best one-way flight to St. Louis from San Diego in the past 72 hours is $204. The best round-trip flight deal from San Diego to St. Louis found on momondo in the last 72 hours is $306.
The fastest flight from San Diego to St. Louis takes 3h 30m
Direct flights go from San Diego to St. Louis every day.
There is 1 airport near St. Louis: Lambert-St Louis (STL)
Search flight deals

  • How far is San Diego to Lambert-St Louis by plane?

    Lambert-St Louis is 1560.0 mi away from San Diego. 3h 40m is a normal flight duration for this route.

  • When did momondo last update prices for flights from San Diego Airport to Lambert-St Louis Airport?

    Prices for flights from San Diego Airport to Lambert-St Louis Airport refresh daily.

  • How many operators does momondo search for flights from San Diego Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from San Diego Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from San Diego Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents you'll need for your trip to Lambert-St Louis Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Lambert-St Louis Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from San Diego to St. Louis?

  • What is the most popular airline from San Diego to St. Louis?

Best airlines flying from San Diego to St. Louis

Compare and see reviews for airlines that fly from San Diego to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $108Free CancellationRating
5.8
3,201 reviews
Search Frontier flights
DeltaPriceFrom $184Free CancellationRating
7.9
7,981 reviews
Search Delta flights
American AirlinesPriceFrom $249Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $256Free CancellationRating
7.4
8,940 reviews
Search United Airlines flights
SouthwestPriceFrom $340Free CancellationRating
8.0
4,243 reviews
Search Southwest flights

  • Southwest Flights From San Diego to St. Louis

    Southwest is one of the most popular airlines flying from San Diego to St. Louis, operating 10 flights/week on average for this route. A good Southwest flight deal for San Diego to St. Louis starts from $340 round-trip, up to an average price of $487. Our users have rated Southwest at 8.0/10.

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Fairview Heights
Hermann
Maryland Heights
Florissant
O'Fallon
Fenton
Collinsville
Wentzville
Alton
St. Peters
Festus
Farmington
Glencoe
Clayton
Edwardsville
Eureka
Litchfield
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to St. Louis?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from San Diego to St. Louis. momondo saves you time and could save you money on your trip.

Can I find flights from San Diego to St. Louis with flexible booking policies on momondo?

Flights from San Diego to St. Louis with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Diego to St. Louis?

Once all potential San Diego to St. Louis flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Diego to St. Louis right now. Can momondo alert me if prices change?

If you are not ready to book a flight from San Diego to St. Louis now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to St. Louis and let you know when they change.

An easier way to manage your St. Louis trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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