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Cheap flights from San Diego to St. Louis from $72

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to St. Louis departing on 11/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from San Diego to St. Louis

Cheap round-trip flights

Frontier Logo
9:03 pm - 9:07 amSAN-STL
10h 04m1 stop
Frontier Logo
7:52 pm - 11:50 pmSTL-SAN
5h 58m1 stop
$144Frontier
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Fri, Oct 17 - Tue, Oct 21
Frontier Logo
6:41 am - 9:07 amSAN-STL
24h 26m1 stop
Frontier Logo
7:52 pm - 10:25 pmSTL-SAN
28h 33m1 stop
$145Frontier
Find Deal
Wed, Oct 8 - Fri, Oct 10
Frontier Logo
7:15 am - 9:06 amSAN-STL
23h 51m1 stop
Frontier Logo
7:52 pm - 11:50 pmSTL-SAN
5h 58m1 stop
$146Frontier
Find Deal
Wed, Oct 1 - Tue, Oct 14
Frontier Logo
9:03 pm - 9:06 amSAN-STL
10h 03m1 stop
Frontier Logo
10:39 am - 4:42 pmSTL-SAN
8h 03m1 stop
$157Frontier
Find Deal
Thu, Oct 2 - Sun, Oct 5
United Airlines Logo
11:11 am - 8:57 pmSAN-STL
7h 46m1 stop
United Airlines Logo
1:35 pm - 5:34 pmSTL-SAN
5h 59m1 stop
$183United Airlines
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Thu, Dec 11 - Tue, Dec 16
United Airlines Logo
11:02 am - 9:54 pmSAN-STL
8h 52m2 stops
United Airlines Logo
4:43 pm - 8:54 pmSTL-SAN
6h 11m1 stop
$188United Airlines
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Sat, Nov 8 - Mon, Nov 10
Multiple Airlines Logo
2:28 pm - 10:02 amSAN-STL
17h 34m1 stop
Multiple Airlines Logo
12:20 pm - 3:56 pmSTL-SAN
29h 36m2 stops
$233Multiple Airlines
Find Deal
Fri, Dec 12 - Sun, Dec 14
Alaska Airlines Logo
11:41 am - 11:59 pmSAN-STL
10h 18m1 stop
Alaska Airlines Logo
7:00 am - 3:06 pmSTL-SAN
10h 06m1 stop
$256Alaska Airlines
Find Deal
Thu, Dec 11 - Mon, Dec 15
Multiple Airlines Logo
10:30 am - 12:03 amSAN-STL
11h 33m2 stops
Multiple Airlines Logo
7:52 pm - 11:50 pmSTL-SAN
5h 58m1 stop
$262Multiple Airlines
Find Deal
Wed, Oct 15 - Wed, Oct 22
Alaska Airlines Logo
11:41 am - 11:59 pmSAN-STL
10h 18m1 stop
Alaska Airlines Logo
7:00 am - 7:52 pmSTL-SAN
14h 52m2 stops
$293Alaska Airlines
Find Deal
Thu, Dec 11 - Mon, Dec 15

Alaska Airlines flights from San Diego to St. Louis

Our best Alaska Airlines deals on San Diego to St. Louis flight tickets
Alaska Airlines
Dec 11
SAN11:41 amSan Diego
10h 18m
1 stop
STL11:59 pmLambert-St Louis
Dec 15
STL7:00 amLambert-St Louis
10h 06m
1 stop
SAN3:06 pmSan Diego
$256
Find similar
Alaska Airlines
Dec 11
SAN11:41 amSan Diego
10h 18m
1 stop
STL11:59 pmLambert-St Louis
Dec 15
STL7:00 amLambert-St Louis
14h 52m
2 stops
SAN7:52 pmSan Diego
$293
Find similar
Alaska Airlines
Feb 20
SAN7:00 amSan Diego
14h 56m
1 stop
STL11:56 pmLambert-St Louis
Feb 23
STL7:00 amLambert-St Louis
14h 12m
2 stops
SAN7:12 pmSan Diego
$303
Find similar

United Airlines flights from San Diego to St. Louis

Our best United Airlines deals on San Diego to St. Louis flight tickets
United Airlines
Dec 11
SAN11:11 amSan Diego
7h 46m
1 stop
STL8:57 pmLambert-St Louis
Dec 16
STL1:35 pmLambert-St Louis
5h 59m
1 stop
SAN5:34 pmSan Diego
$183
Find similar
United Airlines
Nov 8
SAN11:02 amSan Diego
8h 52m
2 stops
STL9:54 pmLambert-St Louis
Nov 10
STL4:43 pmLambert-St Louis
6h 11m
1 stop
SAN8:54 pmSan Diego
$188
Find similar
United Airlines
Dec 7
SAN7:00 amSan Diego
6h 40m
1 stop
STL3:40 pmLambert-St Louis
Dec 9
STL6:15 amLambert-St Louis
6h 46m
1 stop
SAN11:01 amSan Diego
$204
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from San Diego to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Fri 10/17

9:03 pm-9:07 am

1 stop10h 04m

Lambert-St Louis

Tue 10/21

7:52 pm-11:50 pm

1 stop5h 58m

$144

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Wed 10/8

6:41 am-9:07 am

1 stop24h 26m

Lambert-St Louis

Fri 10/10

7:52 pm-10:25 pm

1 stop28h 33m

$145

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Wed 10/1

7:15 am-9:06 am

1 stop23h 51m

Lambert-St Louis

Tue 10/14

7:52 pm-11:50 pm

1 stop5h 58m

$146

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Thu 10/2

9:03 pm-9:06 am

1 stop10h 03m

Lambert-St Louis

Sun 10/5

10:39 am-4:42 pm

1 stop8h 03m

$157

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Thu 12/11

11:11 am-8:57 pm

1 stop7h 46m

Lambert-St Louis

Tue 12/16

1:35 pm-5:34 pm

1 stop5h 59m

$183

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Sat 11/8

11:02 am-9:54 pm

2 stops8h 52m

Lambert-St Louis

Mon 11/10

4:43 pm-8:54 pm

1 stop6h 11m

$188

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Fri 12/12

2:28 pm-10:02 am

1 stop17h 34m

Lambert-St Louis

Sun 12/14

12:20 pm-3:56 pm

2 stops29h 36m

$233

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Thu 12/11

11:41 am-11:59 pm

1 stop10h 18m

Lambert-St Louis

Mon 12/15

7:00 am-3:06 pm

1 stop10h 06m

$256

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Wed 10/15

10:30 am-12:03 am

2 stops11h 33m

Lambert-St Louis

Wed 10/22

7:52 pm-11:50 pm

1 stop5h 58m

$262

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Thu 12/11

11:41 am-11:59 pm

1 stop10h 18m

Lambert-St Louis

Mon 12/15

7:00 am-7:52 pm

2 stops14h 52m

$293

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from San Diego to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, September is the cheapest month to fly from San Diego to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $288. The month of February is another great option to travel to St. Louis, with average flight prices from San Diego averaging around $307.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Thursday when prices can be found for as low as $454. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $536. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from San Diego in the evening is the least expensive time of day to depart. momondo users have found prices as low as $198 when looking at flights departing in the evening. At noon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $501 per ticket.

What is the cheapest San Diego to Lambert-St Louis flight route?

Fly from San Diego to Lambert-St Louis for the best San Diego - Lambert-St Louis flight prices

How far in advance should I book a flight to St. Louis?

You are more likely to see cheaper flights to St. Louis from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $374 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from San Diego for as low as $299 on momondo.

What cabin class options are available on San Diego to Lambert-St Louis flights?

There is only 1 cabin class available to choose from on San Diego to Lambert-St Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on San Diego to St. Louis flights?

You could potentially save up to 26% on your flight if you consider stops on a San Diego to St. Louis flight.

How have San Diego to St. Louis flight prices changed over time?

As of September 2025, prices for San Diego to St. Louis flights are approximately 15% more expensive when compared to flights at the same time last year.

When to book flights from San Diego to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to St. Louis (SAN to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to St. Louis

Best Price Found

$228

Fastest flight time

3h 30m

Direct flights

Every day

Airports in St. Louis

1 airport
The best one-way flight to St. Louis from San Diego in the past 72 hours is $228. The best round-trip flight deal from San Diego to St. Louis found on momondo in the last 72 hours is $296.
The fastest flight from San Diego to St. Louis takes 3h 30m
Direct flights go from San Diego to St. Louis every day.
There is 1 airport near St. Louis: Lambert-St Louis (STL)
Search flight deals

  • How far is San Diego to Lambert-St Louis by plane?

    Lambert-St Louis is 1560.0 mi away from San Diego. 5h 37m is a normal flight duration for this route.

  • When did momondo last update prices for flights from San Diego Airport to Lambert-St Louis Airport?

    Prices for flights from San Diego Airport to Lambert-St Louis Airport refresh daily.

  • How many operators does momondo search for flights from San Diego Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from San Diego Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from San Diego Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents you'll need for your trip to Lambert-St Louis Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Lambert-St Louis Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from San Diego to St. Louis?

  • What is the most popular airline from San Diego to St. Louis?

Best airlines flying from San Diego to St. Louis

Compare and see reviews for airlines that fly from San Diego to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $117Free CancellationRating
5.8
3,173 reviews
Search Frontier flights
DeltaPriceFrom $184Free CancellationRating
7.9
7,961 reviews
Search Delta flights
American AirlinesPriceFrom $249Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $256Free CancellationRating
7.4
8,926 reviews
Search United Airlines flights
SouthwestPriceFrom $325Free CancellationRating
8.0
4,242 reviews
Search Southwest flights

  • Southwest Flights From San Diego to St. Louis

    Southwest is one of the most popular airlines flying from San Diego to St. Louis, operating 11 flights/week on average for this route. A good Southwest flight deal for San Diego to St. Louis starts from $325 round-trip, up to an average price of $491. Our users have rated Southwest at 8.0/10.

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Florissant
Maryland Heights
O'Fallon
Fenton
Collinsville
Wentzville
Alton
St. Peters
Farmington
Festus
Glencoe
Clayton
Edwardsville
Eureka
Litchfield
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to St. Louis?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from San Diego to St. Louis. momondo saves you time and could save you money on your trip.

Can I find flights from San Diego to St. Louis with flexible booking policies on momondo?

Flights from San Diego to St. Louis with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Diego to St. Louis?

Once all potential San Diego to St. Louis flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Diego to St. Louis right now. Can momondo alert me if prices change?

If you are not ready to book a flight from San Diego to St. Louis now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to St. Louis and let you know when they change.

An easier way to manage your St. Louis trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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