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Cheap flights from San Diego to St. Louis from $66

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to St. Louis departing on 1/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
11:47 am - 10:02 amSAN-STL
20h 15m1 stop
Frontier Logo
7:43 pm - 5:09 pmSTL-SAN
23h 26m1 stop
$127Frontier
Find Deal
Thu, Jan 8 - Mon, Jan 12
Frontier Logo
2:50 pm - 10:02 amSAN-STL
17h 12m2 stops
Frontier Logo
7:43 pm - 11:07 pmSTL-SAN
29h 24m1 stop
$162Frontier
Find Deal
Thu, Jan 8 - Mon, Jan 12
Frontier Logo
4:47 pm - 10:14 amSAN-STL
15h 27m1 stop
Frontier Logo
10:44 pm - 12:38 pmSTL-SAN
15h 54m1 stop
$169Frontier
Find Deal
Fri, Dec 12 - Sun, Dec 14
Frontier Logo
8:10 pm - 10:14 amSAN-STL
12h 04m1 stop
Frontier Logo
7:43 pm - 11:59 pmSTL-SAN
6h 16m1 stop
$182Frontier
Find Deal
Thu, Dec 11 - Mon, Dec 15
Frontier Logo
9:16 am - 12:40 pmSAN-STL
25h 24m1 stop
Frontier Logo
4:45 pm - 11:31 pmSTL-SAN
32h 46m2 stops
$201Frontier
Find Deal
Thu, Jan 15 - Tue, Jan 20
Frontier Logo
6:34 am - 10:14 amSAN-STL
25h 40m1 stop
Frontier Logo
10:44 pm - 2:10 pmSTL-SAN
17h 26m2 stops
$207Frontier
Find Deal
Fri, Dec 12 - Sun, Dec 14
Frontier Logo
2:56 pm - 8:48 pmSAN-STL
27h 52m1 stop
Frontier Logo
9:32 pm - 8:51 amSTL-SAN
13h 19m1 stop
$217Frontier
Find Deal
Thu, Jan 29 - Sun, Feb 1
Frontier Logo
4:47 pm - 10:02 amSAN-STL
15h 15m1 stop
Frontier Logo
10:10 pm - 12:11 pmSTL-SAN
16h 01m1 stop
$237Frontier
Find Deal
Fri, Dec 19 - Mon, Dec 22
Frontier Logo
6:25 am - 10:02 amSAN-STL
25h 37m1 stop
Frontier Logo
3:43 pm - 1:51 pmSTL-SAN
48h 08m2 stops
$247Frontier
Find Deal
Tue, Dec 30 - Thu, Jan 8
Frontier Logo
6:34 am - 10:14 amSAN-STL
25h 40m1 stop
Frontier Logo
1:16 pm - 12:38 pmSTL-SAN
25h 22m1 stop
$253Frontier
Find Deal
Tue, Dec 9 - Thu, Dec 11

Frontier flights from San Diego to St. Louis

Our best Frontier deals on San Diego to St. Louis flight tickets
Frontier
Jan 8
SAN11:47 amSan Diego
20h 15m
1 stop
STL10:02 amLambert-St Louis
Jan 12
STL7:43 pmLambert-St Louis
23h 26m
1 stop
SAN5:09 pmSan Diego
$127
Find similar
Frontier
Jan 9
SAN4:47 pmSan Diego
15h 15m
1 stop
STL10:02 amLambert-St Louis
Jan 12
STL7:43 pmLambert-St Louis
23h 26m
1 stop
SAN5:09 pmSan Diego
$129
Find similar
Frontier
Jan 8
SAN2:50 pmSan Diego
17h 12m
2 stops
STL10:02 amLambert-St Louis
Jan 12
STL7:43 pmLambert-St Louis
29h 24m
1 stop
SAN11:07 pmSan Diego
$162
Find similar

Delta flights from San Diego to St. Louis

Our best Delta deals on San Diego to St. Louis flight tickets
Delta
Jan 29
SAN11:00 amSan Diego
10h 25m
2 stops
STL11:25 pmLambert-St Louis
Feb 1
STL6:10 amLambert-St Louis
10h 19m
2 stops
SAN2:29 pmSan Diego
$276
Find similar
Delta
Jan 29
SAN6:15 amSan Diego
8h 22m
1 stop
STL4:37 pmLambert-St Louis
Feb 1
STL6:10 amLambert-St Louis
10h 19m
2 stops
SAN2:29 pmSan Diego
$304
Find similar
Delta
Jan 8
SAN6:15 amSan Diego
6h 33m
1 stop
STL2:48 pmLambert-St Louis
Jan 9
STL7:00 amLambert-St Louis
7h 22m
1 stop
SAN12:22 pmSan Diego
$318
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 24, 2025.
Use the filters below to find and compare flights from San Diego to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Thu 1/8

11:47 am-10:02 am

1 stop20h 15m

Lambert-St Louis

Mon 1/12

7:43 pm-5:09 pm

1 stop23h 26m

$127

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Thu 1/8

2:50 pm-10:02 am

2 stops17h 12m

Lambert-St Louis

Mon 1/12

7:43 pm-11:07 pm

1 stop29h 24m

$162

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Fri 12/12

4:47 pm-10:14 am

1 stop15h 27m

Lambert-St Louis

Sun 12/14

10:44 pm-12:38 pm

1 stop15h 54m

$169

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Thu 12/11

8:10 pm-10:14 am

1 stop12h 04m

Lambert-St Louis

Mon 12/15

7:43 pm-11:59 pm

1 stop6h 16m

$182

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Thu 1/15

9:16 am-12:40 pm

1 stop25h 24m

Lambert-St Louis

Tue 1/20

4:45 pm-11:31 pm

2 stops32h 46m

$201

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Fri 12/12

6:34 am-10:14 am

1 stop25h 40m

Lambert-St Louis

Sun 12/14

10:44 pm-2:10 pm

2 stops17h 26m

$207

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Thu 1/29

2:56 pm-8:48 pm

1 stop27h 52m

Lambert-St Louis

Sun 2/1

9:32 pm-8:51 am

1 stop13h 19m

$217

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Fri 12/19

4:47 pm-10:02 am

1 stop15h 15m

Lambert-St Louis

Mon 12/22

10:10 pm-12:11 pm

1 stop16h 01m

$237

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Tue 12/30

6:25 am-10:02 am

1 stop25h 37m

Lambert-St Louis

Thu 1/8

3:43 pm-1:51 pm

2 stops48h 08m

$247

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Tue 12/9

6:34 am-10:14 am

1 stop25h 40m

Lambert-St Louis

Thu 12/11

1:16 pm-12:38 pm

1 stop25h 22m

$253

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from San Diego to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, September is the cheapest month to fly from San Diego to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $271. The month of February is another great option to travel to St. Louis, with average flight prices from San Diego averaging around $307.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Friday when prices can be found for as low as $433. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $549. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from San Diego in the evening is the least expensive time of day to depart. momondo users have found prices as low as $198 when looking at flights departing in the evening. In the afternoon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $493 per ticket.

What is the cheapest San Diego to Lambert-St Louis flight route?

Fly from San Diego to Lambert-St Louis for the best San Diego - Lambert-St Louis flight prices

How far in advance should I book a flight to St. Louis?

You are more likely to see cheaper flights to St. Louis from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $381 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from San Diego for as low as $306 on momondo.

What cabin class options are available on San Diego to Lambert-St Louis flights?

There is only 1 cabin class available to choose from on San Diego to Lambert-St Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on San Diego to St. Louis flights?

You could potentially save up to 43% on your flight if you consider stops on a San Diego to St. Louis flight.

How have San Diego to St. Louis flight prices changed over time?

As of November 2025, prices for San Diego to St. Louis flights are approximately 1% more expensive when compared to flights at the same time last year.

When to book flights from San Diego to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to St. Louis (SAN to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to St. Louis

Best Price Found

$166

Fastest flight time

3h 30m

Direct flights

Every day

Airports in St. Louis

1 airport
The best one-way flight to St. Louis from San Diego in the past 72 hours is $166. The best round-trip flight deal from San Diego to St. Louis found on momondo in the last 72 hours is $318.
The fastest flight from San Diego to St. Louis takes 3h 30m
Direct flights go from San Diego to St. Louis every day.
There is 1 airport near St. Louis: Lambert-St Louis (STL)
Search flight deals

  • How far is San Diego to Lambert-St Louis by plane?

    Lambert-St Louis is 1560.0 mi away from San Diego. 3h 30m is a normal flight duration for this route.

  • When did momondo last update prices for flights from San Diego Airport to Lambert-St Louis Airport?

    Prices for flights from San Diego Airport to Lambert-St Louis Airport refresh daily.

  • How many operators does momondo search for flights from San Diego Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from San Diego Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from San Diego Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents you'll need for your trip to Lambert-St Louis Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Lambert-St Louis Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from San Diego to St. Louis?

  • What is the most popular airline from San Diego to St. Louis?

Best airlines flying from San Diego to St. Louis

Compare and see reviews for airlines that fly from San Diego to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $128Free CancellationRating
5.8
3,099 reviews
Search Frontier flights
DeltaPriceFrom $184Free CancellationRating
7.9
7,997 reviews
Search Delta flights
American AirlinesPriceFrom $249Free CancellationRating
7.2
11,046 reviews
Search American Airlines flights
United AirlinesPriceFrom $256Free CancellationRating
7.4
9,036 reviews
Search United Airlines flights
SouthwestPriceFrom $306Free CancellationRating
8.0
4,252 reviews
Search Southwest flights

  • Southwest Flights From San Diego to St. Louis

    Southwest is one of the most popular airlines flying from San Diego to St. Louis, operating 12 flights/week on average for this route. A good Southwest flight deal for San Diego to St. Louis starts from $306 round-trip, up to an average price of $479. Our users have rated Southwest at 8.0/10.

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Florissant
Maryland Heights
O'Fallon
Wentzville
Fenton
Collinsville
St. Peters
Alton
Farmington
Festus
Glencoe
Edwardsville
Clayton
Eureka
Litchfield
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to St. Louis?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from San Diego to St. Louis. momondo saves you time and could save you money on your trip.

Can I find flights from San Diego to St. Louis with flexible booking policies on momondo?

Flights from San Diego to St. Louis with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Diego to St. Louis?

Once all potential San Diego to St. Louis flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from San Diego to St. Louis right now. Can momondo alert me if prices change?

If you are not ready to book a flight from San Diego to St. Louis now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to St. Louis and let you know when they change.

An easier way to manage your St. Louis trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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