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Cheap flights from San Diego to Knoxville from $144

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from San Diego to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
2:45 pm - 10:14 pmSAN  San Diego-TYS Knoxville McGhee Tyson
28h 29m1 stop Phoenix Sky Harbor Intl
Multiple Airlines Logo
10:00 am - 7:44 amTYS  Knoxville McGhee Tyson-SAN San Diego
24h 44m1 stop Phoenix Sky Harbor Intl
$243Multiple Airlines
Wed, Dec 23 - Sun, Jan 10
Multiple Airlines Logo
2:45 pm - 10:14 pmSAN  San Diego-TYS Knoxville McGhee Tyson
28h 29m1 stop Phoenix Sky Harbor Intl
Multiple Airlines Logo
10:00 am - 2:14 pmTYS  Knoxville McGhee Tyson-SAN San Diego
7h 14m1 stop Phoenix Sky Harbor Intl
$253Multiple Airlines
Wed, Dec 23 - Thu, Jan 14
Delta Logo
12:31 pm - 11:24 pmSAN  San Diego-TYS Knoxville McGhee Tyson
7h 53m1 stop Minneapolis St Paul
Delta Logo
5:40 am - 11:54 amTYS  Knoxville McGhee Tyson-SAN San Diego
9h 14m1 stop Atlanta Hartsfield-Jackson
$311Delta
Wed, Dec 2 - Tue, Dec 8
Southwest Logo
6:35 am - 7:50 pmSAN  San Diego-TYS Knoxville McGhee Tyson
10h 15m2 stops Denver Intl Nashville Intl
Southwest Logo
5:15 pm - 11:10 pmTYS  Knoxville McGhee Tyson-SAN San Diego
8h 55m1 stop Nashville Intl
$342Southwest
Wed, Dec 2 - Tue, Dec 8
United Airlines Logo
10:40 am - 8:54 pmSAN  San Diego-TYS Knoxville McGhee Tyson
7h 14m1 stop Chicago O'Hare Intl
United Airlines Logo
5:45 am - 11:43 amTYS  Knoxville McGhee Tyson-SAN San Diego
8h 58m1 stop Washington, D.C. Dulles Intl
$343United Airlines
Mon, Nov 23 - Thu, Nov 26
American Airlines Logo
9:45 pm - 8:49 amSAN  San Diego-TYS Knoxville McGhee Tyson
8h 04m1 stop Charlotte Douglas
American Airlines Logo
4:17 pm - 8:50 pmTYS  Knoxville McGhee Tyson-SAN San Diego
7h 33m1 stop Charlotte Douglas
$354American Airlines
Mon, Nov 30 - Sat, Dec 12
American Airlines Logo
10:50 pm - 9:01 amSAN  San Diego-TYS Knoxville McGhee Tyson
7h 11m1 stop Charlotte Douglas
American Airlines Logo
6:14 am - 10:38 amTYS  Knoxville McGhee Tyson-SAN San Diego
7h 24m1 stop Charlotte Douglas
$363American Airlines
Mon, Jan 4 - Fri, Jan 8
Delta Logo
10:30 pm - 10:01 amSAN  San Diego-TYS Knoxville McGhee Tyson
8h 31m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:10 pm - 10:15 pmTYS  Knoxville McGhee Tyson-SAN San Diego
8h 05m1 stop Detroit Metropolitan Wayne County
$363Delta
Wed, Dec 2 - Tue, Dec 8
United Airlines Logo
10:30 am - 8:47 pmSAN  San Diego-TYS Knoxville McGhee Tyson
7h 17m1 stop Chicago O'Hare Intl
United Airlines Logo
9:45 am - 3:18 pmTYS  Knoxville McGhee Tyson-SAN San Diego
8h 33m1 stop Washington, D.C. Dulles Intl
$363United Airlines
Sat, Dec 12 - Wed, Dec 16
Southwest Logo
6:50 am - 3:55 pmSAN  San Diego-TYS Knoxville McGhee Tyson
6h 05m1 stop Denver Intl
Southwest Logo
5:50 pm - 10:30 pmTYS  Knoxville McGhee Tyson-SAN San Diego
7h 40m1 stop Denver Intl
$363Southwest
Wed, Jan 6 - Wed, Jan 20

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Southwest flights from San Diego to Knoxville

Our best Southwest deals on San Diego to Knoxville flight tickets
Southwest
Dec 2
SAN6:35 amSan Diego
10h 15m
2 stops
TYS7:50 pmKnoxville McGhee Tyson
Dec 8
TYS5:15 pmKnoxville McGhee Tyson
8h 55m
1 stop
SAN11:10 pmSan Diego
$342
Southwest
Jan 6
SAN8:05 amSan Diego
7h 30m
2 stops
TYS6:35 pmKnoxville McGhee Tyson
Jan 20
TYS6:45 amKnoxville McGhee Tyson
10h 50m
2 stops
SAN2:35 pmSan Diego
$373
Southwest
Jan 4
SAN10:35 pmSan Diego
10h 45m
1 stop
TYS12:20 pmKnoxville McGhee Tyson
Jan 8
TYS6:45 amKnoxville McGhee Tyson
10h 50m
2 stops
SAN2:35 pmSan Diego
$374

American Airlines flights from San Diego to Knoxville

Our best American Airlines deals on San Diego to Knoxville flight tickets
American Airlines
Nov 12
SAN12:00 pmSan Diego
8h 58m
1 stop
TYS11:58 pmKnoxville McGhee Tyson
Nov 14
TYS2:13 pmKnoxville McGhee Tyson
9h 33m
1 stop
SAN8:46 pmSan Diego
$397
American Airlines
Dec 3
SAN2:18 pmSan Diego
6h 22m
1 stop
TYS11:40 pmKnoxville McGhee Tyson
Dec 6
TYS5:30 amKnoxville McGhee Tyson
7h 53m
1 stop
SAN10:23 amSan Diego
$399
American Airlines
Nov 26
SAN6:15 amSan Diego
7h 25m
1 stop
TYS4:40 pmKnoxville McGhee Tyson
Dec 1
TYS5:30 pmKnoxville McGhee Tyson
7h 25m
1 stop
SAN9:55 pmSan Diego
$407

momondo Fare Finder

 
Use the filters below to find and compare flights from San Diego to Knoxville that are best for you.

Fly from

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Route

Depart

Return

Price

Cheapest round-trip

San DiegoKnoxville

SAN San Diego - TYS Knoxville McGhee Tyson

SANTYS

San Diego

Wed 12/23

2:45 pm-10:14 pm

1 stop28h 29m

Knoxville McGhee Tyson

Sun 1/10

10:00 am-7:44 am

1 stop24h 44m

$243

San DiegoKnoxville

SAN San Diego - TYS Knoxville McGhee Tyson

SANTYS

San Diego

Wed 12/23

2:45 pm-10:14 pm

1 stop28h 29m

Knoxville McGhee Tyson

Thu 1/14

10:00 am-2:14 pm

1 stop7h 14m

$253

San DiegoKnoxville

SAN San Diego - TYS Knoxville McGhee Tyson

SANTYS

San Diego

Wed 12/2

12:31 pm-11:24 pm

1 stop7h 53m

Knoxville McGhee Tyson

Tue 12/8

5:40 am-11:54 am

1 stop9h 14m

$311

San DiegoKnoxville

SAN San Diego - TYS Knoxville McGhee Tyson

SANTYS

San Diego

Wed 12/2

6:35 am-7:50 pm

2 stops10h 15m

Knoxville McGhee Tyson

Tue 12/8

5:15 pm-11:10 pm

1 stop8h 55m

$342

San DiegoKnoxville

SAN San Diego - TYS Knoxville McGhee Tyson

SANTYS

San Diego

Mon 11/23

10:40 am-8:54 pm

1 stop7h 14m

Knoxville McGhee Tyson

Thu 11/26

5:45 am-11:43 am

1 stop8h 58m

$343

San DiegoKnoxville

SAN San Diego - TYS Knoxville McGhee Tyson

SANTYS

San Diego

Mon 11/30

9:45 pm-8:49 am

1 stop8h 04m

Knoxville McGhee Tyson

Sat 12/12

4:17 pm-8:50 pm

1 stop7h 33m

$354

San DiegoKnoxville

SAN San Diego - TYS Knoxville McGhee Tyson

SANTYS

San Diego

Mon 1/4

10:50 pm-9:01 am

1 stop7h 11m

Knoxville McGhee Tyson

Fri 1/8

6:14 am-10:38 am

1 stop7h 24m

$363

San DiegoKnoxville

SAN San Diego - TYS Knoxville McGhee Tyson

SANTYS

San Diego

Wed 12/2

10:30 pm-10:01 am

1 stop8h 31m

Knoxville McGhee Tyson

Tue 12/8

5:10 pm-10:15 pm

1 stop8h 05m

$363

San DiegoKnoxville

SAN San Diego - TYS Knoxville McGhee Tyson

SANTYS

San Diego

Sat 12/12

10:30 am-8:47 pm

1 stop7h 17m

Knoxville McGhee Tyson

Wed 12/16

9:45 am-3:18 pm

1 stop8h 33m

$363
Quickest round-trip

San DiegoKnoxville

SAN San Diego - TYS Knoxville McGhee Tyson

SANTYS

San Diego

Wed 1/6

6:50 am-3:55 pm

1 stop6h 05m

Knoxville McGhee Tyson

Wed 1/20

5:50 pm-10:30 pm

1 stop7h 40m

$363

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from San Diego to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Diego and Knoxville?

Prices are currently low for flights on this route.

Typical prices usually range from $386 to $594.
The lowest price recently found on this route was $243.

What is the cheapest month to fly to Knoxville?

The month of December is, on average, the cheapest month to fly to Knoxville from San Diego, with most prices found around $414. If you aren’t able to travel during the month of December, then book flights to Knoxville from San Diego during May instead. Flights to Knoxville in May, while not as cheap as those in December, still average around $414.

What is the cheapest San Diego to Knoxville McGhee Tyson flight route?

Fly from San Diego to Knoxville McGhee Tyson for the best San Diego - Knoxville McGhee Tyson flight prices

How far in advance should I book a flight from San Diego to Knoxville?

You are more likely to see cheaper flights to Knoxville from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $470 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from San Diego for as low as $358 on momondo.

What cabin class options are available on San Diego to Knoxville flights?

There is only 1 cabin class available to choose from on San Diego to Knoxville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have San Diego to Knoxville flight prices changed over time?

As of November 2026, prices for San Diego to Knoxville flights are approximately 118% more expensive when compared to flights at the same time last year.

When to book flights from San Diego to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to Knoxville (SAN to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Knoxville

Best Price Found

$144

Fastest flight time

6h 53m

Direct flights

None
The best one-way flight to Knoxville from San Diego in the past 72 hours is $144. The best round-trip flight deal from San Diego to Knoxville found on momondo in the last 72 hours is $243.
The fastest flight from San Diego to Knoxville takes 6h 53m
There are no direct flights from San Diego to Knoxville. There are no popular flight routes from San Diego to Knoxville.
Search flight deals

Frequently asked questions about flying from San Diego to Knoxville

  • How far is San Diego to Knoxville McGhee Tyson by plane?

    There are 1898.9 mi between San Diego and Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 6h 53m.

  • When did momondo last update prices for flights from San Diego Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Diego Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Diego Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Diego Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from San Diego Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from San Diego to Knoxville?

Best airlines flying from San Diego to Knoxville

Compare and see reviews for airlines that fly from San Diego to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $65Free CancellationRating
5.5
2,511 reviews
Search Frontier flights
United AirlinesPriceFrom $276Free CancellationRating
7.3
10,463 reviews
Search United Airlines flights
DeltaPriceFrom $296Free CancellationRating
7.8
8,697 reviews
Search Delta flights
SouthwestPriceFrom $312Free CancellationRating
8.0
4,220 reviews
Search Southwest flights
American AirlinesPriceFrom $316Free CancellationRating
7.0
12,222 reviews
Search American Airlines flights
Alaska AirlinesPriceFrom $496Free CancellationRating
7.9
13,137 reviews
Search Alaska Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Kodak
Oak Ridge
Lenoir City
Newport
Dandridge
Clinton
Rockford
Jefferson City

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Diego to Knoxville for you.

Can I find flights from San Diego to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from San Diego on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Diego to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from San Diego. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from San Diego to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from San Diego. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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