Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from San Diego to Knoxville from $164

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to Knoxville departing on 9/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from San Diego to Knoxville

Cheap round-trip flights

Logo
6:41 am - 1:44 pmSAN-TYS
28h 03m1 stop
Logo
7:17 pm - 11:50 pmTYS-SAN
7h 33m1 stop
$213
Find Deal
mié., nov. 12 - jue., nov. 13
Frontier Logo
6:41 am - 7:32 pmSAN-TYS
9h 51m1 stop
Frontier Logo
7:17 pm - 4:38 pmTYS-SAN
24h 21m2 stops
$215Frontier
Find Deal
lun., oct. 27 - jue., nov. 6
Logo
6:41 am - 7:32 pmSAN-TYS
9h 51m1 stop
Logo
7:00 am - 11:17 amTYS-SAN
7h 17m1 stop
$220
Find Deal
lun., oct. 27 - dom., nov. 2
Frontier Logo
6:35 am - 7:50 pmSAN-TYS
10h 15m1 stop
Frontier Logo
8:35 pm - 11:53 pmTYS-SAN
6h 18m1 stop
$238Frontier
Find Deal
jue., sep. 25 - lun., sep. 29
American Airlines Logo
9:54 pm - 8:34 amSAN-TYS
7h 40m1 stop
American Airlines Logo
7:59 am - 12:33 pmTYS-SAN
7h 34m1 stop
$243American Airlines
Find Deal
sáb., nov. 8 - mar., nov. 11
United Airlines Logo
12:55 pm - 11:59 pmSAN-TYS
8h 04m1 stop
United Airlines Logo
4:50 pm - 9:07 pmTYS-SAN
7h 17m1 stop
$277United Airlines
Find Deal
mié., nov. 12 - sáb., nov. 15
Delta Logo
10:30 pm - 10:28 amSAN-TYS
8h 58m1 stop
Delta Logo
5:16 pm - 11:14 pmTYS-SAN
8h 58m1 stop
$297Delta
Find Deal
vie., oct. 31 - mié., nov. 5
American Airlines Logo
12:50 pm - 8:34 amSAN-TYS
16h 44m2 stops
American Airlines Logo
5:03 pm - 11:00 pmTYS-SAN
8h 57m1 stop
$301American Airlines
Find Deal
jue., nov. 27 - mié., dic. 3
Delta Logo
10:30 pm - 9:20 amSAN-TYS
7h 50m1 stop
Delta Logo
5:44 am - 9:48 amTYS-SAN
7h 04m1 stop
$308Delta
Find Deal
mié., oct. 29 - mar., nov. 4
United Airlines Logo
11:02 am - 10:30 pmSAN-TYS
8h 28m2 stops
United Airlines Logo
4:50 pm - 9:07 pmTYS-SAN
7h 17m1 stop
$320United Airlines
Find Deal
mié., nov. 12 - sáb., nov. 15

Frontier flights from San Diego to Knoxville

Our best Frontier deals on San Diego to Knoxville flight tickets
Frontier
Oct 27
SAN6:41 amSan Diego
9h 51m
1 stop
TYS7:32 pmKnoxville McGhee Tyson
Nov 6
TYS7:17 pmKnoxville McGhee Tyson
24h 21m
2 stops
SAN4:38 pmSan Diego
$215
Find similar
Frontier
Sep 25
SAN6:35 amSan Diego
10h 15m
1 stop
TYS7:50 pmKnoxville McGhee Tyson
Sep 29
TYS8:35 pmKnoxville McGhee Tyson
6h 18m
1 stop
SAN11:53 pmSan Diego
$238
Find similar
Frontier
Sep 25
SAN6:35 amSan Diego
10h 15m
1 stop
TYS7:50 pmKnoxville McGhee Tyson
Sep 28
TYS5:08 pmKnoxville McGhee Tyson
9h 45m
1 stop
SAN11:53 pmSan Diego
$261
Find similar

United Airlines flights from San Diego to Knoxville

Our best United Airlines deals on San Diego to Knoxville flight tickets
United Airlines
Nov 12
SAN12:55 pmSan Diego
8h 04m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Nov 15
TYS4:50 pmKnoxville McGhee Tyson
7h 17m
1 stop
SAN9:07 pmSan Diego
$277
Find similar
United Airlines
Nov 12
SAN11:02 amSan Diego
8h 28m
2 stops
TYS10:30 pmKnoxville McGhee Tyson
Nov 15
TYS4:50 pmKnoxville McGhee Tyson
7h 17m
1 stop
SAN9:07 pmSan Diego
$320
Find similar
United Airlines
Sep 17
SAN10:54 amSan Diego
9h 50m
2 stops
TYS11:44 pmKnoxville McGhee Tyson
Sep 24
TYS7:20 amKnoxville McGhee Tyson
6h 35m
1 stop
SAN10:55 amSan Diego
$386
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated septiembre 15, 2025.
Use the filters below to find and compare flights from San Diego to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

mié. 11/12

6:41 am-1:44 pm

1 stop28h 03m

Knoxville McGhee Tyson

jue. 11/13

7:17 pm-11:50 pm

1 stop7h 33m

$213

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

lun. 10/27

6:41 am-7:32 pm

1 stop9h 51m

Knoxville McGhee Tyson

jue. 11/6

7:17 pm-4:38 pm

2 stops24h 21m

$215

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

lun. 10/27

6:41 am-7:32 pm

1 stop9h 51m

Knoxville McGhee Tyson

dom. 11/2

7:00 am-11:17 am

1 stop7h 17m

$220

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

jue. 9/25

6:35 am-7:50 pm

1 stop10h 15m

Knoxville McGhee Tyson

lun. 9/29

8:35 pm-11:53 pm

1 stop6h 18m

$238

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

sáb. 11/8

9:54 pm-8:34 am

1 stop7h 40m

Knoxville McGhee Tyson

mar. 11/11

7:59 am-12:33 pm

1 stop7h 34m

$243

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

mié. 11/12

12:55 pm-11:59 pm

1 stop8h 04m

Knoxville McGhee Tyson

sáb. 11/15

4:50 pm-9:07 pm

1 stop7h 17m

$277

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

vie. 10/31

10:30 pm-10:28 am

1 stop8h 58m

Knoxville McGhee Tyson

mié. 11/5

5:16 pm-11:14 pm

1 stop8h 58m

$297

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

jue. 11/27

12:50 pm-8:34 am

2 stops16h 44m

Knoxville McGhee Tyson

mié. 12/3

5:03 pm-11:00 pm

1 stop8h 57m

$301

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

mié. 10/29

10:30 pm-9:20 am

1 stop7h 50m

Knoxville McGhee Tyson

mar. 11/4

5:44 am-9:48 am

1 stop7h 04m

$308

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

mié. 11/12

11:02 am-10:30 pm

2 stops8h 28m

Knoxville McGhee Tyson

sáb. 11/15

4:50 pm-9:07 pm

1 stop7h 17m

$320

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 19 resultsSorted by cheapest first
1
2

See travel insights to Knoxville from

How to get the cheapest flight ticket from San Diego to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from San Diego, with most prices found around $316. If you aren’t able to travel during the month of January, then book flights to Knoxville from San Diego during July instead. Flights to Knoxville in July, while not as cheap as those in January, still average around $345.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from San Diego to Knoxville is on a Wednesday. Travelers who choose to depart for Knoxville on a Wednesday will often find tickets for as low as $391. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from San Diego to Knoxville for around $660.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from San Diego to Knoxville when you can find flight prices for as low as $413. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $528.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $432 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from San Diego for as low as $303 on momondo.

How have San Diego to Knoxville flight prices changed over time?

As of September 2025, prices for San Diego to Knoxville flights are approximately 1% cheaper when compared to flights at the same time last year.

When to book flights from San Diego to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to Knoxville (SAN to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Knoxville

Direct flights

None
There are no direct flights from San Diego to Knoxville. There are no popular flight routes from San Diego to Knoxville.
Search flight deals

  • How far is San Diego to Knoxville McGhee Tyson by plane?

    There are 1898.9 mi between San Diego and Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 5h 45m.

  • When did momondo last update prices for flights from San Diego Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Diego Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Diego Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Diego Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from San Diego Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from San Diego to Knoxville?

Best airlines flying from San Diego to Knoxville

Compare and see reviews for airlines that fly from San Diego to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $84Free CancellationRating
5.8
3,172 reviews
Search Frontier flights
United AirlinesPriceFrom $228Free CancellationRating
7.4
8,929 reviews
Search United Airlines flights
DeltaPriceFrom $276Free CancellationRating
7.9
7,954 reviews
Search Delta flights
American AirlinesPriceFrom $279Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
Alaska AirlinesPriceFrom $378Free CancellationRating
8.0
10,000 reviews
Search Alaska Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Newport
Lenoir City
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Diego to Knoxville for you.

Can I find flights from San Diego to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from San Diego on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Diego to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from San Diego. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from San Diego to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from San Diego. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Knoxville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
mié. 10/15
mié. 10/22
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States