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Cheap flights from San Diego to Knoxville from $134

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from San Diego to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
8:17 am - 8:25 pmSAN  San Diego-TYS Knoxville McGhee Tyson
9h 08m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
9:15 pm - 7:29 amTYS  Knoxville McGhee Tyson-SAN San Diego
13h 14m1 stop Las Vegas Harry Reid Intl
$282Multiple Airlines
Fri, Dec 4 - Mon, Dec 7
Multiple Airlines Logo
8:17 am - 8:25 pmSAN  San Diego-TYS Knoxville McGhee Tyson
9h 08m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
8:00 am - 11:58 pmTYS  Knoxville McGhee Tyson-SAN San Diego
18h 58m2 stops Austin Bergstrom Denver Intl
$295Multiple Airlines
Fri, Dec 4 - Mon, Dec 7
Delta Logo
11:31 am - 9:37 pmSAN  San Diego-TYS Knoxville McGhee Tyson
7h 06m1 stop Detroit Metropolitan Wayne County
Delta Logo
7:26 am - 2:20 pmTYS  Knoxville McGhee Tyson-SAN San Diego
9h 54m1 stop Detroit Metropolitan Wayne County
$339Delta
Fri, Oct 30 - Fri, Nov 6
American Airlines Logo
11:17 am - 11:18 pmSAN  San Diego-TYS Knoxville McGhee Tyson
9h 01m1 stop Dallas/Fort Worth
American Airlines Logo
7:25 am - 2:17 pmTYS  Knoxville McGhee Tyson-SAN San Diego
9h 52m1 stop Dallas/Fort Worth
$363American Airlines
Sat, Oct 24 - Sat, Oct 31
American Airlines Logo
9:25 pm - 8:32 amSAN  San Diego-TYS Knoxville McGhee Tyson
8h 07m1 stop Charlotte Douglas
American Airlines Logo
5:32 pm - 11:56 pmTYS  Knoxville McGhee Tyson-SAN San Diego
9h 24m1 stop Dallas/Fort Worth
$363American Airlines
Sat, Oct 24 - Mon, Nov 2
Delta Logo
6:15 am - 6:22 pmSAN  San Diego-TYS Knoxville McGhee Tyson
9h 07m1 stop Detroit Metropolitan Wayne County
Delta Logo
4:01 pm - 7:59 pmTYS  Knoxville McGhee Tyson-SAN San Diego
6h 58m1 stop Atlanta Hartsfield-Jackson
$363Delta
Wed, Dec 2 - Sat, Dec 5
United Airlines Logo
6:50 am - 4:59 pmSAN  San Diego-TYS Knoxville McGhee Tyson
7h 09m1 stop Chicago O'Hare Intl
United Airlines Logo
5:03 pm - 8:36 pmTYS  Knoxville McGhee Tyson-SAN San Diego
6h 33m1 stop Denver Intl
$363United Airlines
Wed, Nov 11 - Sat, Nov 14
Southwest Logo
7:45 am - 6:45 pmSAN  San Diego-TYS Knoxville McGhee Tyson
8h 00m1 stop Denver Intl
Southwest Logo
7:25 pm - 12:25 amTYS  Knoxville McGhee Tyson-SAN San Diego
8h 00m1 stop Nashville Intl
$363Southwest
Mon, Nov 2 - Mon, Nov 9
United Airlines Logo
12:04 pm - 9:55 pmSAN  San Diego-TYS Knoxville McGhee Tyson
6h 51m1 stop Houston George Bush Intcntl
United Airlines Logo
10:51 am - 5:17 pmTYS  Knoxville McGhee Tyson-SAN San Diego
9h 26m2 stops Chicago O'Hare Intl Los Angeles
$368United Airlines
Sat, Oct 24 - Sat, Oct 31
Southwest Logo
6:45 am - 6:45 pmSAN  San Diego-TYS Knoxville McGhee Tyson
9h 00m2 stops Phoenix Sky Harbor Intl Denver Intl
Southwest Logo
2:50 pm - 8:30 pmTYS  Knoxville McGhee Tyson-SAN San Diego
8h 40m1 stop Nashville Intl
$368Southwest
Thu, Nov 12 - Sat, Nov 14

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American Airlines flights from San Diego to Knoxville

Our best American Airlines deals on San Diego to Knoxville flight tickets
American Airlines
Nov 26
SAN6:15 amSan Diego
7h 25m
1 stop
TYS4:40 pmKnoxville McGhee Tyson
Dec 1
TYS5:30 amKnoxville McGhee Tyson
7h 53m
1 stop
SAN10:23 amSan Diego
$363
American Airlines
Oct 30
SAN11:58 amSan Diego
8h 57m
1 stop
TYS11:55 pmKnoxville McGhee Tyson
Nov 5
TYS5:32 pmKnoxville McGhee Tyson
9h 24m
1 stop
SAN11:56 pmSan Diego
$392
American Airlines
Nov 1
SAN7:00 amSan Diego
9h 34m
1 stop
TYS7:34 pmKnoxville McGhee Tyson
Nov 11
TYS5:32 pmKnoxville McGhee Tyson
7h 18m
1 stop
SAN9:50 pmSan Diego
$415

United Airlines flights from San Diego to Knoxville

Our best United Airlines deals on San Diego to Knoxville flight tickets
United Airlines
Oct 17
SAN12:04 pmSan Diego
6h 51m
1 stop
TYS9:55 pmKnoxville McGhee Tyson
Oct 24
TYS1:55 pmKnoxville McGhee Tyson
9h 13m
2 stops
SAN8:08 pmSan Diego
$368
United Airlines
Nov 5
SAN11:21 amSan Diego
8h 11m
1 stop
TYS10:32 pmKnoxville McGhee Tyson
Nov 9
TYS5:40 pmKnoxville McGhee Tyson
8h 00m
1 stop
SAN10:40 pmSan Diego
$453
United Airlines
Nov 26
SAN12:05 pmSan Diego
6h 52m
1 stop
TYS9:57 pmKnoxville McGhee Tyson
Dec 2
TYS7:00 amKnoxville McGhee Tyson
10h 55m
2 stops
SAN2:55 pmSan Diego
$488

momondo Fare Finder

 
Use the filters below to find and compare flights from San Diego to Knoxville that are best for you.

Fly from

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Route

Depart

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Price

Cheapest round-trip

San DiegoKnoxville

SAN San Diego - TYS Knoxville McGhee Tyson

SANTYS

San Diego

Fri 12/4

8:17 am-8:25 pm

1 stop9h 08m

Knoxville McGhee Tyson

Mon 12/7

9:15 pm-7:29 am

1 stop13h 14m

$282

San DiegoKnoxville

SAN San Diego - TYS Knoxville McGhee Tyson

SANTYS

San Diego

Fri 12/4

8:17 am-8:25 pm

1 stop9h 08m

Knoxville McGhee Tyson

Mon 12/7

8:00 am-11:58 pm

2 stops18h 58m

$295

San DiegoKnoxville

SAN San Diego - TYS Knoxville McGhee Tyson

SANTYS

San Diego

Fri 10/30

11:31 am-9:37 pm

1 stop7h 06m

Knoxville McGhee Tyson

Fri 11/6

7:26 am-2:20 pm

1 stop9h 54m

$339

San DiegoKnoxville

SAN San Diego - TYS Knoxville McGhee Tyson

SANTYS

San Diego

Sat 10/24

11:17 am-11:18 pm

1 stop9h 01m

Knoxville McGhee Tyson

Sat 10/31

7:25 am-2:17 pm

1 stop9h 52m

$363

San DiegoKnoxville

SAN San Diego - TYS Knoxville McGhee Tyson

SANTYS

San Diego

Sat 10/24

9:25 pm-8:32 am

1 stop8h 07m

Knoxville McGhee Tyson

Mon 11/2

5:32 pm-11:56 pm

1 stop9h 24m

$363

San DiegoKnoxville

SAN San Diego - TYS Knoxville McGhee Tyson

SANTYS

San Diego

Wed 12/2

6:15 am-6:22 pm

1 stop9h 07m

Knoxville McGhee Tyson

Sat 12/5

4:01 pm-7:59 pm

1 stop6h 58m

$363
Quickest round-trip

San DiegoKnoxville

SAN San Diego - TYS Knoxville McGhee Tyson

SANTYS

San Diego

Wed 11/11

6:50 am-4:59 pm

1 stop7h 09m

Knoxville McGhee Tyson

Sat 11/14

5:03 pm-8:36 pm

1 stop6h 33m

$363

San DiegoKnoxville

SAN San Diego - TYS Knoxville McGhee Tyson

SANTYS

San Diego

Mon 11/2

7:45 am-6:45 pm

1 stop8h 00m

Knoxville McGhee Tyson

Mon 11/9

7:25 pm-12:25 am

1 stop8h 00m

$363

San DiegoKnoxville

SAN San Diego - TYS Knoxville McGhee Tyson

SANTYS

San Diego

Sat 10/24

12:04 pm-9:55 pm

1 stop6h 51m

Knoxville McGhee Tyson

Sat 10/31

10:51 am-5:17 pm

2 stops9h 26m

$368

San DiegoKnoxville

SAN San Diego - TYS Knoxville McGhee Tyson

SANTYS

San Diego

Thu 11/12

6:45 am-6:45 pm

2 stops9h 00m

Knoxville McGhee Tyson

Sat 11/14

2:50 pm-8:30 pm

1 stop8h 40m

$368

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from San Diego to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Diego and Knoxville?

Prices are currently low for flights on this route.

Typical prices usually range from $428 to $551.
The lowest price recently found on this route was $277.

What is the cheapest month to fly to Knoxville?

The month of May is, on average, the cheapest month to fly to Knoxville from San Diego, with most prices found around $414. If you aren’t able to travel during the month of May, then book flights to Knoxville from San Diego during December instead. Flights to Knoxville in December, while not as cheap as those in May, still average around $444.

What is the cheapest San Diego to Knoxville McGhee Tyson flight route?

Fly from San Diego to Knoxville McGhee Tyson for the best San Diego - Knoxville McGhee Tyson flight prices

How far in advance should I book a flight from San Diego to Knoxville?

You are more likely to see cheaper flights to Knoxville from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $480 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from San Diego for as low as $357 on momondo.

What cabin class options are available on San Diego to Knoxville flights?

There is only 1 cabin class available to choose from on San Diego to Knoxville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have San Diego to Knoxville flight prices changed over time?

As of September 2026, prices for San Diego to Knoxville flights are approximately 97% more expensive when compared to flights at the same time last year.

When to book flights from San Diego to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to Knoxville (SAN to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Knoxville

Best Price Found

$134

Fastest flight time

6h 37m

Direct flights

None
The best one-way flight to Knoxville from San Diego in the past 72 hours is $134. The best round-trip flight deal from San Diego to Knoxville found on momondo in the last 72 hours is $282.
The fastest flight from San Diego to Knoxville takes 6h 37m
There are no direct flights from San Diego to Knoxville. There are no popular flight routes from San Diego to Knoxville.
Search flight deals

Frequently asked questions about flying from San Diego to Knoxville

  • How far is San Diego to Knoxville McGhee Tyson by plane?

    There are 1898.9 mi between San Diego and Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 6h 37m.

  • When did momondo last update prices for flights from San Diego Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Diego Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Diego Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Diego Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from San Diego Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from San Diego to Knoxville?

Best airlines flying from San Diego to Knoxville

Compare and see reviews for airlines that fly from San Diego to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $65Free CancellationRating
5.6
2,579 reviews
Search Frontier flights
United AirlinesPriceFrom $276Free CancellationRating
7.4
10,226 reviews
Search United Airlines flights
DeltaPriceFrom $277Free CancellationRating
7.8
8,591 reviews
Search Delta flights
American AirlinesPriceFrom $307Free CancellationRating
7.0
12,076 reviews
Search American Airlines flights
SouthwestPriceFrom $336Free CancellationRating
8.0
4,198 reviews
Search Southwest flights
Alaska AirlinesPriceFrom $496Free CancellationRating
7.9
12,959 reviews
Search Alaska Airlines flights

  • United Airlines Flights From San Diego to Knoxville

    Across 3 United Airlines flights from San Diego to Knoxville this week, the average price was $471, with the best United Airlines deals starting from $276 round-trip. 10,230 users have rated United Airlines on momondo, with an average score of 7.4/10.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Alcoa
Corbin
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Dandridge
Lenoir City
Clinton
Rockford
Jefferson City

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Diego to Knoxville for you.

Can I find flights from San Diego to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from San Diego on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Diego to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from San Diego. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from San Diego to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from San Diego. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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