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Cheap flights from San Diego to Knoxville from $139

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to Knoxville departing on 9/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from San Diego to Knoxville

Cheap round-trip flights

Logo
9:34 am - 10:24 pmSAN-TYS
9h 50m1 stop
Logo
1:52 pm - 8:55 pmTYS-SAN
10h 03m1 stop
$252
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Thu, Aug 21 - Sun, Aug 24
Logo
6:15 am - 10:30 pmSAN-TYS
13h 15m1 stop
Logo
8:30 am - 10:26 pmTYS-SAN
16h 56m1 stop
$255
Find Deal
Fri, Sep 12 - Mon, Sep 15
Frontier Logo
12:05 pm - 4:29 pmSAN-TYS
25h 24m1 stop
Frontier Logo
5:25 pm - 9:52 amTYS-SAN
19h 27m1 stop
$267Frontier
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Wed, Aug 13 - Sun, Aug 17
American Airlines Logo
3:14 pm - 12:23 amSAN-TYS
6h 09m1 stop
American Airlines Logo
6:47 pm - 10:59 pmTYS-SAN
7h 12m1 stop
$277American Airlines
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Wed, Oct 8 - Sat, Oct 11
Frontier Logo
6:25 am - 7:41 pmSAN-TYS
10h 16m1 stop
Frontier Logo
7:10 pm - 11:52 pmTYS-SAN
7h 42m1 stop
$278Frontier
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Thu, Aug 21 - Mon, Aug 25
American Airlines Logo
1:00 pm - 10:59 pmSAN-TYS
6h 59m1 stop
American Airlines Logo
2:07 pm - 8:20 pmTYS-SAN
9h 13m1 stop
$283American Airlines
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Tue, Aug 26 - Wed, Sep 3
Delta Logo
11:23 am - 9:19 pmSAN-TYS
6h 56m1 stop
Delta Logo
4:13 pm - 7:27 pmTYS-SAN
6h 14m1 stop
$328Delta
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Sun, Sep 14 - Tue, Sep 23
Delta Logo
10:40 pm - 11:34 amSAN-TYS
9h 54m1 stop
Delta Logo
5:45 am - 9:27 amTYS-SAN
6h 42m1 stop
$334Delta
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Fri, Aug 29 - Mon, Sep 1
United Airlines Logo
12:01 pm - 11:44 pmSAN-TYS
8h 43m1 stop
United Airlines Logo
4:40 pm - 8:25 pmTYS-SAN
6h 45m1 stop
$373United Airlines
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Tue, Aug 26 - Wed, Sep 3
United Airlines Logo
8:37 pm - 10:13 amSAN-TYS
10h 36m2 stops
United Airlines Logo
9:30 am - 1:54 pmTYS-SAN
7h 24m1 stop
$378United Airlines
Find Deal
Tue, Aug 26 - Wed, Sep 3

American Airlines flights from San Diego to Knoxville

Our best American Airlines deals on San Diego to Knoxville flight tickets
American Airlines
Oct 8
SAN3:14 pmSan Diego
6h 09m
1 stop
TYS12:23 amKnoxville McGhee Tyson
Oct 11
TYS6:47 pmKnoxville McGhee Tyson
7h 12m
1 stop
SAN10:59 pmSan Diego
$277
Find similar
American Airlines
Aug 26
SAN1:00 pmSan Diego
6h 59m
1 stop
TYS10:59 pmKnoxville McGhee Tyson
Sep 3
TYS2:07 pmKnoxville McGhee Tyson
9h 13m
1 stop
SAN8:20 pmSan Diego
$283
Find similar
American Airlines
Aug 28
SAN12:23 pmSan Diego
8h 30m
1 stop
TYS11:53 pmKnoxville McGhee Tyson
Sep 1
TYS5:06 amKnoxville McGhee Tyson
7h 07m
1 stop
SAN9:13 amSan Diego
$289
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United Airlines flights from San Diego to Knoxville

Our best United Airlines deals on San Diego to Knoxville flight tickets
United Airlines
Aug 26
SAN12:01 pmSan Diego
8h 43m
1 stop
TYS11:44 pmKnoxville McGhee Tyson
Sep 3
TYS4:40 pmKnoxville McGhee Tyson
6h 45m
1 stop
SAN8:25 pmSan Diego
$373
Find similar
United Airlines
Aug 26
SAN8:37 pmSan Diego
10h 36m
2 stops
TYS10:13 amKnoxville McGhee Tyson
Sep 3
TYS9:30 amKnoxville McGhee Tyson
7h 24m
1 stop
SAN1:54 pmSan Diego
$378
Find similar
United Airlines
Sep 14
SAN8:37 pmSan Diego
10h 36m
2 stops
TYS10:13 amKnoxville McGhee Tyson
Sep 23
TYS5:10 pmKnoxville McGhee Tyson
9h 34m
2 stops
SAN11:44 pmSan Diego
$383
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from San Diego to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Thu 8/21

9:34 am-10:24 pm

1 stop9h 50m

Knoxville McGhee Tyson

Sun 8/24

1:52 pm-8:55 pm

1 stop10h 03m

$252

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Fri 9/12

6:15 am-10:30 pm

1 stop13h 15m

Knoxville McGhee Tyson

Mon 9/15

8:30 am-10:26 pm

1 stop16h 56m

$255

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Wed 8/13

12:05 pm-4:29 pm

1 stop25h 24m

Knoxville McGhee Tyson

Sun 8/17

5:25 pm-9:52 am

1 stop19h 27m

$267

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Wed 10/8

3:14 pm-12:23 am

1 stop6h 09m

Knoxville McGhee Tyson

Sat 10/11

6:47 pm-10:59 pm

1 stop7h 12m

$277

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Thu 8/21

6:25 am-7:41 pm

1 stop10h 16m

Knoxville McGhee Tyson

Mon 8/25

7:10 pm-11:52 pm

1 stop7h 42m

$278

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Tue 8/26

1:00 pm-10:59 pm

1 stop6h 59m

Knoxville McGhee Tyson

Wed 9/3

2:07 pm-8:20 pm

1 stop9h 13m

$283

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Sun 9/14

11:23 am-9:19 pm

1 stop6h 56m

Knoxville McGhee Tyson

Tue 9/23

4:13 pm-7:27 pm

1 stop6h 14m

$328

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Fri 8/29

10:40 pm-11:34 am

1 stop9h 54m

Knoxville McGhee Tyson

Mon 9/1

5:45 am-9:27 am

1 stop6h 42m

$334

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Tue 8/26

12:01 pm-11:44 pm

1 stop8h 43m

Knoxville McGhee Tyson

Wed 9/3

4:40 pm-8:25 pm

1 stop6h 45m

$373

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Tue 8/26

8:37 pm-10:13 am

2 stops10h 36m

Knoxville McGhee Tyson

Wed 9/3

9:30 am-1:54 pm

1 stop7h 24m

$378

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from San Diego to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from San Diego, with most prices found around $318. If you aren’t able to travel during the month of January, then book flights to Knoxville from San Diego during July instead. Flights to Knoxville in July, while not as cheap as those in January, still average around $338.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from San Diego to Knoxville is on a Wednesday. Travelers who choose to depart for Knoxville on a Wednesday will often find tickets for as low as $391. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from San Diego to Knoxville for around $660.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from San Diego to Knoxville when you can find flight prices for as low as $413. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $528.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $427 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from San Diego for as low as $303 on momondo.

How have San Diego to Knoxville flight prices changed over time?

As of July 2025, prices for San Diego to Knoxville flights are approximately 26% cheaper when compared to flights at the same time last year.

When to book flights from San Diego to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to Knoxville (SAN to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Knoxville

Best Price Found

$139

Fastest flight time

5h 50m

Direct flights

None

Airports in Knoxville

1 airport
The best one-way flight to Knoxville from San Diego in the past 72 hours is $139. The best round-trip flight deal from San Diego to Knoxville found on momondo in the last 72 hours is $252.
The fastest flight from San Diego to Knoxville takes 5h 50m
There are no direct flights from San Diego to Knoxville. Popular non-direct route for this connection is San Diego Airport - Knoxville McGhee Tyson Airport.
There is 1 airport near Knoxville: Knoxville McGhee Tyson (TYS)
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  • How far is San Diego to Knoxville McGhee Tyson by plane?

    There are 1898.9 mi between San Diego and Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 6h 09m.

  • When did momondo last update prices for flights from San Diego Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Diego Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Diego Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Diego Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from San Diego Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from San Diego to Knoxville?

Best airlines flying from San Diego to Knoxville

Compare and see reviews for airlines that fly from San Diego to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $84Free CancellationRating
5.9
3,239 reviews
Search Frontier flights
United AirlinesPriceFrom $228Free CancellationRating
7.4
8,900 reviews
Search United Airlines flights
DeltaPriceFrom $276Free CancellationRating
8.0
7,981 reviews
Search Delta flights
American AirlinesPriceFrom $282Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
Alaska AirlinesPriceFrom $378Free CancellationRating
8.0
10,000 reviews
Search Alaska Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Newport
Alcoa
Lenoir City
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Diego to Knoxville for you.

Can I find flights from San Diego to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from San Diego on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Diego to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from San Diego. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from San Diego to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from San Diego. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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