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Cheap flights from San Diego to Knoxville from $105

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to Knoxville departing on 5/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from San Diego to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
6:25 am - 7:33 pm
SAN
-
TYS
10h 08m
1 stop
Frontier Logo
8:32 pm - 8:42 am
TYS
-
SAN
15h 10m
1 stop
$221Frontier
Fri, May 8 - Mon, May 11
Frontier Logo
6:25 am - 7:33 pm
SAN
-
TYS
10h 08m
1 stop
Frontier Logo
8:32 pm - 8:42 am
TYS
-
SAN
15h 10m
1 stop
$289Frontier
Fri, May 15 - Fri, May 22
United Airlines Logo
10:46 am - 8:45 pm
SAN
-
TYS
6h 59m
1 stop
United Airlines Logo
5:55 pm - 10:39 pm
TYS
-
SAN
7h 44m
1 stop
$297United Airlines
Tue, May 5 - Tue, May 12
United Airlines Logo
11:01 am - 11:41 pm
SAN
-
TYS
9h 40m
2 stops
United Airlines Logo
5:15 pm - 9:26 pm
TYS
-
SAN
7h 11m
1 stop
$302United Airlines
Tue, Apr 7 - Tue, Apr 14
Multiple Airlines Logo
6:25 am - 3:28 pm
SAN
-
TYS
30h 03m
1 stop
Multiple Airlines Logo
8:00 am - 7:21 am
TYS
-
SAN
26h 21m
1 stop
$303Multiple Airlines
Sun, Apr 5 - Sun, Apr 12
American Airlines Logo
6:15 am - 3:19 pm
SAN
-
TYS
6h 04m
1 stop
American Airlines Logo
4:09 pm - 10:00 pm
TYS
-
SAN
8h 51m
1 stop
$307American Airlines
Sat, May 2 - Tue, May 5
American Airlines Logo
8:18 am - 5:36 pm
SAN
-
TYS
6h 18m
1 stop
American Airlines Logo
2:27 pm - 7:55 pm
TYS
-
SAN
8h 28m
1 stop
$317American Airlines
Tue, Sep 1 - Sat, Sep 19
Multiple Airlines Logo
6:25 am - 3:28 pm
SAN
-
TYS
30h 03m
1 stop
Multiple Airlines Logo
8:00 am - 7:21 am
TYS
-
SAN
26h 21m
1 stop
$322Multiple Airlines
Sun, Apr 5 - Sun, Apr 12
Multiple Airlines Logo
9:53 am - 10:56 pm
SAN
-
TYS
10h 03m
1 stop
Multiple Airlines Logo
7:00 am - 10:21 am
TYS
-
SAN
30h 21m
1 stop
$323Multiple Airlines
Thu, Jul 23 - Sun, Jul 26
United Airlines Logo
10:55 am - 11:12 pm
SAN
-
TYS
9h 17m
2 stops
United Airlines Logo
4:56 pm - 8:46 pm
TYS
-
SAN
6h 50m
1 stop
$324United Airlines
Sat, May 23 - Wed, May 27

Delta flights from San Diego to Knoxville

Our best Delta deals on San Diego to Knoxville flight tickets
Delta
May 28
SAN12:48 pmSan Diego
8h 08m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
Jun 1
TYS3:05 pmKnoxville McGhee Tyson
9h 55m
1 stop
SAN10:00 pmSan Diego
$399
Delta
Jul 24
SAN10:40 pmSan Diego
7h 31m
1 stop
TYS9:11 amKnoxville McGhee Tyson
Jul 28
TYS3:20 pmKnoxville McGhee Tyson
9h 24m
1 stop
SAN9:44 pmSan Diego
$414
Delta
Mar 19
SAN2:09 pmSan Diego
6h 48m
1 stop
TYS11:57 pmKnoxville McGhee Tyson
Mar 21
TYS5:40 amKnoxville McGhee Tyson
7h 18m
1 stop
SAN9:58 amSan Diego
$568

American Airlines flights from San Diego to Knoxville

Our best American Airlines deals on San Diego to Knoxville flight tickets
American Airlines
May 2
SAN6:15 amSan Diego
6h 04m
1 stop
TYS3:19 pmKnoxville McGhee Tyson
May 5
TYS4:09 pmKnoxville McGhee Tyson
8h 51m
1 stop
SAN10:00 pmSan Diego
$307
American Airlines
Sep 1
SAN8:18 amSan Diego
6h 18m
1 stop
TYS5:36 pmKnoxville McGhee Tyson
Sep 19
TYS2:27 pmKnoxville McGhee Tyson
8h 28m
1 stop
SAN7:55 pmSan Diego
$317
American Airlines
Apr 7
SAN12:17 pmSan Diego
8h 39m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
Apr 16
TYS6:54 pmKnoxville McGhee Tyson
8h 02m
1 stop
SAN11:56 pmSan Diego
$339

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 16, 2026.
Use the filters below to find and compare flights from San Diego to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Fri 5/8

6:25 am-7:33 pm

1 stop10h 08m

Knoxville McGhee Tyson

Mon 5/11

8:32 pm-8:42 am

1 stop15h 10m

$221

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Fri 5/15

6:25 am-7:33 pm

1 stop10h 08m

Knoxville McGhee Tyson

Fri 5/22

8:32 pm-8:42 am

1 stop15h 10m

$289
Quickest round-trip

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Tue 5/5

10:46 am-8:45 pm

1 stop6h 59m

Knoxville McGhee Tyson

Tue 5/12

5:55 pm-10:39 pm

1 stop7h 44m

$297

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Tue 4/7

11:01 am-11:41 pm

2 stops9h 40m

Knoxville McGhee Tyson

Tue 4/14

5:15 pm-9:26 pm

1 stop7h 11m

$302

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Sun 4/5

6:25 am-3:28 pm

1 stop30h 03m

Knoxville McGhee Tyson

Sun 4/12

8:00 am-7:21 am

1 stop26h 21m

$303

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Sat 5/2

6:15 am-3:19 pm

1 stop6h 04m

Knoxville McGhee Tyson

Tue 5/5

4:09 pm-10:00 pm

1 stop8h 51m

$307

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Tue 9/1

8:18 am-5:36 pm

1 stop6h 18m

Knoxville McGhee Tyson

Sat 9/19

2:27 pm-7:55 pm

1 stop8h 28m

$317

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Sun 4/5

6:25 am-3:28 pm

1 stop30h 03m

Knoxville McGhee Tyson

Sun 4/12

8:00 am-7:21 am

1 stop26h 21m

$322

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Thu 7/23

9:53 am-10:56 pm

1 stop10h 03m

Knoxville McGhee Tyson

Sun 7/26

7:00 am-10:21 am

1 stop30h 21m

$323

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Sat 5/23

10:55 am-11:12 pm

2 stops9h 17m

Knoxville McGhee Tyson

Wed 5/27

4:56 pm-8:46 pm

1 stop6h 50m

$324

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from San Diego to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of September is, on average, the cheapest month to fly to Knoxville from San Diego, with most prices found around $292. If you aren’t able to travel during the month of September, then book flights to Knoxville from San Diego during July instead. Flights to Knoxville in July, while not as cheap as those in September, still average around $338.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $418 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from San Diego for as low as $335 on momondo.

How have San Diego to Knoxville flight prices changed over time?

As of March 2026, prices for San Diego to Knoxville flights are approximately 36% more expensive when compared to flights at the same time last year.

When to book flights from San Diego to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to Knoxville (SAN to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Knoxville

Fastest flight time

7h 31m

Direct flights

None
The fastest flight from San Diego to Knoxville takes 7h 31m
There are no direct flights from San Diego to Knoxville. There are no popular flight routes from San Diego to Knoxville.
Search flight deals

  • How far is San Diego to Knoxville McGhee Tyson by plane?

    There are 1898.9 mi between San Diego and Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 7h 31m.

  • When did momondo last update prices for flights from San Diego Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Diego Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Diego Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Diego Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from San Diego Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from San Diego to Knoxville?

Best airlines flying from San Diego to Knoxville

Compare and see reviews for airlines that fly from San Diego to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $65Free CancellationRating
5.7
3,030 reviews
Search Frontier flights
United AirlinesPriceFrom $228Free CancellationRating
7.4
9,428 reviews
Search United Airlines flights
American AirlinesPriceFrom $276Free CancellationRating
7.1
11,465 reviews
Search American Airlines flights
DeltaPriceFrom $276Free CancellationRating
7.9
8,292 reviews
Search Delta flights
Alaska AirlinesPriceFrom $503Free CancellationRating
7.9
12,052 reviews
Search Alaska Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Jefferson City
Dandridge
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Diego to Knoxville for you.

Can I find flights from San Diego to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from San Diego on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Diego to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from San Diego. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from San Diego to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from San Diego. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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