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Cheap flights from San Diego to Knoxville from $103

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to Knoxville departing on 11/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

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Multiple Airlines Logo
8:56 am - 7:10 pmSAN-TYS
7h 14m1 stop
Multiple Airlines Logo
6:30 am - 11:59 pmTYS-SAN
20h 29m1 stop
$192Multiple Airlines
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Sat, Nov 22 - Sun, Nov 23
Frontier Logo
8:56 am - 7:10 pmSAN-TYS
7h 14m1 stop
Frontier Logo
4:48 pm - 11:59 pmTYS-SAN
10h 11m1 stop
$215Frontier
Find Deal
Sat, Nov 22 - Tue, Nov 25
Multiple Airlines Logo
4:33 pm - 7:14 pmSAN-TYS
23h 41m1 stop
Multiple Airlines Logo
6:30 am - 1:33 pmTYS-SAN
10h 03m2 stops
$221Multiple Airlines
Find Deal
Sun, Dec 7 - Thu, Dec 11
Delta Logo
10:40 pm - 9:13 amSAN-TYS
7h 33m1 stop
Delta Logo
5:00 pm - 11:11 pmTYS-SAN
9h 11m1 stop
$277Delta
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Tue, Feb 24 - Sat, Feb 28
United Airlines Logo
10:30 pm - 10:05 amSAN-TYS
8h 35m1 stop
United Airlines Logo
4:59 pm - 9:51 pmTYS-SAN
7h 52m1 stop
$321United Airlines
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Wed, Nov 26 - Wed, Dec 3
Delta Logo
12:05 pm - 11:00 pmSAN-TYS
7h 55m1 stop
Delta Logo
12:00 pm - 9:51 pmTYS-SAN
12h 51m2 stops
$345Delta
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Tue, Feb 24 - Sat, Feb 28
American Airlines Logo
6:20 am - 10:09 pmSAN-TYS
12h 49m1 stop
American Airlines Logo
7:54 am - 1:08 pmTYS-SAN
8h 14m1 stop
$350American Airlines
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Thu, Jan 15 - Tue, Jan 20
United Airlines Logo
10:30 pm - 10:17 amSAN-TYS
8h 47m1 stop
United Airlines Logo
11:10 am - 8:49 pmTYS-SAN
12h 39m2 stops
$359United Airlines
Find Deal
Fri, Dec 26 - Tue, Jan 13
American Airlines Logo
6:15 am - 4:25 pmSAN-TYS
7h 10m1 stop
American Airlines Logo
6:25 pm - 10:07 pmTYS-SAN
6h 42m1 stop
$364American Airlines
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Fri, Feb 20 - Fri, Feb 27
Alaska Airlines Logo
7:21 am - 5:29 pmSAN-TYS
7h 08m1 stop
Alaska Airlines Logo
4:22 pm - 10:13 amTYS-SAN
20h 51m2 stops
$449Alaska Airlines
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Thu, Dec 11 - Sat, Dec 13

Frontier flights from San Diego to Knoxville

Our best Frontier deals on San Diego to Knoxville flight tickets
Frontier
Nov 22
SAN8:56 amSan Diego
7h 14m
1 stop
TYS7:10 pmKnoxville McGhee Tyson
Nov 25
TYS4:48 pmKnoxville McGhee Tyson
10h 11m
1 stop
SAN11:59 pmSan Diego
$215
Find similar
Frontier
Dec 15
SAN6:34 amSan Diego
6h 23m
1 stop
TYS3:57 pmKnoxville McGhee Tyson
Dec 22
TYS4:46 pmKnoxville McGhee Tyson
10h 13m
1 stop
SAN11:59 pmSan Diego
$236
Find similar
Frontier
Nov 8
SAN7:30 pmSan Diego
19h 52m
1 stop
TYS6:22 pmKnoxville McGhee Tyson
Nov 22
TYS8:05 pmKnoxville McGhee Tyson
6h 54m
1 stop
SAN11:59 pmSan Diego
$265
Find similar

American Airlines flights from San Diego to Knoxville

Our best American Airlines deals on San Diego to Knoxville flight tickets
American Airlines
Jan 15
SAN6:20 amSan Diego
12h 49m
1 stop
TYS10:09 pmKnoxville McGhee Tyson
Jan 20
TYS7:54 amKnoxville McGhee Tyson
8h 14m
1 stop
SAN1:08 pmSan Diego
$350
Find similar
American Airlines
Feb 20
SAN6:15 amSan Diego
7h 10m
1 stop
TYS4:25 pmKnoxville McGhee Tyson
Feb 27
TYS6:25 pmKnoxville McGhee Tyson
6h 42m
1 stop
SAN10:07 pmSan Diego
$364
Find similar
American Airlines
Feb 20
SAN6:15 amSan Diego
7h 10m
1 stop
TYS4:25 pmKnoxville McGhee Tyson
Feb 23
TYS4:29 pmKnoxville McGhee Tyson
6h 58m
1 stop
SAN8:27 pmSan Diego
$374
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from San Diego to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Sat 11/22

8:56 am-7:10 pm

1 stop7h 14m

Knoxville McGhee Tyson

Sun 11/23

6:30 am-11:59 pm

1 stop20h 29m

$192

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Sat 11/22

8:56 am-7:10 pm

1 stop7h 14m

Knoxville McGhee Tyson

Tue 11/25

4:48 pm-11:59 pm

1 stop10h 11m

$215

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Sun 12/7

4:33 pm-7:14 pm

1 stop23h 41m

Knoxville McGhee Tyson

Thu 12/11

6:30 am-1:33 pm

2 stops10h 03m

$221

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Tue 2/24

10:40 pm-9:13 am

1 stop7h 33m

Knoxville McGhee Tyson

Sat 2/28

5:00 pm-11:11 pm

1 stop9h 11m

$277

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Wed 11/26

10:30 pm-10:05 am

1 stop8h 35m

Knoxville McGhee Tyson

Wed 12/3

4:59 pm-9:51 pm

1 stop7h 52m

$321

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Tue 2/24

12:05 pm-11:00 pm

1 stop7h 55m

Knoxville McGhee Tyson

Sat 2/28

12:00 pm-9:51 pm

2 stops12h 51m

$345

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Thu 1/15

6:20 am-10:09 pm

1 stop12h 49m

Knoxville McGhee Tyson

Tue 1/20

7:54 am-1:08 pm

1 stop8h 14m

$350

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Fri 12/26

10:30 pm-10:17 am

1 stop8h 47m

Knoxville McGhee Tyson

Tue 1/13

11:10 am-8:49 pm

2 stops12h 39m

$359

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Fri 2/20

6:15 am-4:25 pm

1 stop7h 10m

Knoxville McGhee Tyson

Fri 2/27

6:25 pm-10:07 pm

1 stop6h 42m

$364

San DiegoKnoxville

SAN - TYS

SANTYS

San Diego

Thu 12/11

7:21 am-5:29 pm

1 stop7h 08m

Knoxville McGhee Tyson

Sat 12/13

4:22 pm-10:13 am

2 stops20h 51m

$449

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from San Diego to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from San Diego, with most prices found around $316. If you aren’t able to travel during the month of January, then book flights to Knoxville from San Diego during July instead. Flights to Knoxville in July, while not as cheap as those in January, still average around $345.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from San Diego to Knoxville is on a Wednesday. Travelers who choose to depart for Knoxville on a Wednesday will often find tickets for as low as $391. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from San Diego to Knoxville for around $660.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from San Diego to Knoxville when you can find flight prices for as low as $413. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $528.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $433 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from San Diego for as low as $321 on momondo.

How have San Diego to Knoxville flight prices changed over time?

As of October 2025, prices for San Diego to Knoxville flights are approximately 41% more expensive when compared to flights at the same time last year.

When to book flights from San Diego to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to Knoxville (SAN to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Knoxville

Direct flights

None
There are no direct flights from San Diego to Knoxville. There are no popular flight routes from San Diego to Knoxville.
Search flight deals

  • How far is San Diego to Knoxville McGhee Tyson by plane?

    There are 1898.9 mi between San Diego and Knoxville McGhee Tyson. In terms of flight time, this usually takes a little over 6h 03m.

  • When did momondo last update prices for flights from San Diego Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Diego Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from San Diego Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Diego Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from San Diego Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from San Diego to Knoxville?

Best airlines flying from San Diego to Knoxville

Compare and see reviews for airlines that fly from San Diego to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $84Free CancellationRating
5.8
3,122 reviews
Search Frontier flights
United AirlinesPriceFrom $228Free CancellationRating
7.4
8,998 reviews
Search United Airlines flights
DeltaPriceFrom $276Free CancellationRating
7.9
7,998 reviews
Search Delta flights
American AirlinesPriceFrom $277Free CancellationRating
7.2
11,035 reviews
Search American Airlines flights
Alaska AirlinesPriceFrom $378Free CancellationRating
8.0
11,217 reviews
Search Alaska Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Knoxville?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from San Diego to Knoxville for you.

Can I find flights from San Diego to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from San Diego on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Diego to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from San Diego. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from San Diego to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from San Diego. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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