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Cheap flights from San Diego to Des Moines from $135

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from San Diego to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
5:54 pm - 9:06 pmSAN  San Diego-DSM Des Moines
25h 12m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
9:31 pm - 4:59 pmDSM  Des Moines-SAN San Diego
21h 28m1 stop Las Vegas Harry Reid Intl
$211Multiple Airlines
Wed, Sep 16 - Mon, Sep 21
Multiple Airlines Logo
9:03 pm - 7:48 pmSAN  San Diego-DSM Des Moines
20h 45m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
9:31 pm - 4:59 pmDSM  Des Moines-SAN San Diego
21h 28m1 stop Las Vegas Harry Reid Intl
$225Multiple Airlines
Thu, Sep 17 - Mon, Sep 21
Frontier Logo
6:25 am - 7:30 pmSAN  San Diego-DSM Des Moines
11h 05m1 stop Denver Intl
Frontier Logo
8:25 pm - 3:58 pmDSM  Des Moines-SAN San Diego
21h 33m1 stop Denver Intl
$271Frontier
Fri, Oct 9 - Mon, Oct 12
Frontier Logo
6:25 am - 7:30 pmSAN  San Diego-DSM Des Moines
11h 05m1 stop Denver Intl
Frontier Logo
8:25 pm - 3:58 pmDSM  Des Moines-SAN San Diego
21h 33m1 stop Denver Intl
$272Frontier
Fri, Oct 9 - Mon, Oct 12
American Airlines Logo
6:15 am - 1:34 pmSAN  San Diego-DSM Des Moines
5h 19m1 stop Phoenix Sky Harbor Intl
American Airlines Logo
7:23 am - 12:39 pmDSM  Des Moines-SAN San Diego
7h 16m1 stop Chicago O'Hare Intl
$355American Airlines
Wed, Oct 21 - Tue, Nov 3
United Airlines Logo
12:04 pm - 10:15 pmSAN  San Diego-DSM Des Moines
8h 11m1 stop Houston George Bush Intcntl
United Airlines Logo
5:15 pm - 10:28 pmDSM  Des Moines-SAN San Diego
7h 13m1 stop Denver Intl
$355United Airlines
Wed, Oct 21 - Thu, Dec 3
Delta Logo
6:15 am - 2:08 pmSAN  San Diego-DSM Des Moines
5h 53m1 stop Minneapolis St Paul
Delta Logo
6:41 am - 1:03 pmDSM  Des Moines-SAN San Diego
8h 22m1 stop Minneapolis St Paul
$355Delta
Thu, Nov 26 - Tue, Dec 1
United Airlines Logo
7:00 am - 4:20 pmSAN  San Diego-DSM Des Moines
7h 20m1 stop Denver Intl
United Airlines Logo
5:30 am - 11:31 amDSM  Des Moines-SAN San Diego
8h 01m2 stops Denver Intl Los Angeles
$360United Airlines
Wed, Oct 21 - Tue, Nov 3
American Airlines Logo
6:25 am - 2:37 pmSAN  San Diego-DSM Des Moines
6h 12m1 stop Phoenix Sky Harbor Intl
American Airlines Logo
5:00 am - 8:40 amDSM  Des Moines-SAN San Diego
5h 40m1 stop Phoenix Sky Harbor Intl
$393American Airlines
Thu, Nov 26 - Tue, Dec 1
Delta Logo
6:15 am - 2:08 pmSAN  San Diego-DSM Des Moines
5h 53m1 stop Minneapolis St Paul
Delta Logo
7:55 pm - 11:53 pmDSM  Des Moines-SAN San Diego
5h 58m1 stop Minneapolis St Paul
$426Delta
Mon, Nov 23 - Mon, Nov 30

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Frontier flights from San Diego to Des Moines

Our best Frontier deals on San Diego to Des Moines flight tickets
Frontier
Oct 9
SAN6:25 amSan Diego
11h 05m
1 stop
DSM7:30 pmDes Moines
Oct 12
DSM8:25 pmDes Moines
21h 33m
1 stop
SAN3:58 pmSan Diego
$271
Frontier
Oct 9
SAN6:25 amSan Diego
11h 05m
1 stop
DSM7:30 pmDes Moines
Oct 12
DSM8:25 pmDes Moines
21h 33m
1 stop
SAN3:58 pmSan Diego
$272
Frontier
Oct 9
SAN6:25 amSan Diego
11h 05m
1 stop
DSM7:30 pmDes Moines
Oct 12
DSM8:25 pmDes Moines
5h 31m
1 stop
SAN11:56 pmSan Diego
$300

United Airlines flights from San Diego to Des Moines

Our best United Airlines deals on San Diego to Des Moines flight tickets
United Airlines
Oct 21
SAN12:04 pmSan Diego
8h 11m
1 stop
DSM10:15 pmDes Moines
Dec 3
DSM5:15 pmDes Moines
7h 13m
1 stop
SAN10:28 pmSan Diego
$355
United Airlines
Oct 21
SAN7:00 amSan Diego
7h 20m
1 stop
DSM4:20 pmDes Moines
Nov 3
DSM5:30 amDes Moines
8h 01m
2 stops
SAN11:31 amSan Diego
$360
United Airlines
Sep 23
SAN2:24 pmSan Diego
7h 09m
2 stops
DSM11:33 pmDes Moines
Sep 30
DSM5:45 amDes Moines
7h 50m
2 stops
SAN11:35 amSan Diego
$366

momondo Fare Finder

 
Use the filters below to find and compare flights from San Diego to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San DiegoDes Moines

SAN San Diego - DSM Des Moines

SANDSM

San Diego

Wed 9/16

5:54 pm-9:06 pm

1 stop25h 12m

Des Moines

Mon 9/21

9:31 pm-4:59 pm

1 stop21h 28m

$211

San DiegoDes Moines

SAN San Diego - DSM Des Moines

SANDSM

San Diego

Thu 9/17

9:03 pm-7:48 pm

1 stop20h 45m

Des Moines

Mon 9/21

9:31 pm-4:59 pm

1 stop21h 28m

$225

San DiegoDes Moines

SAN San Diego - DSM Des Moines

SANDSM

San Diego

Fri 10/9

6:25 am-7:30 pm

1 stop11h 05m

Des Moines

Mon 10/12

8:25 pm-3:58 pm

1 stop21h 33m

$271

San DiegoDes Moines

SAN San Diego - DSM Des Moines

SANDSM

San Diego

Fri 10/9

6:25 am-7:30 pm

1 stop11h 05m

Des Moines

Mon 10/12

8:25 pm-3:58 pm

1 stop21h 33m

$272

San DiegoDes Moines

SAN San Diego - DSM Des Moines

SANDSM

San Diego

Wed 10/21

6:15 am-1:34 pm

1 stop5h 19m

Des Moines

Tue 11/3

7:23 am-12:39 pm

1 stop7h 16m

$355

San DiegoDes Moines

SAN San Diego - DSM Des Moines

SANDSM

San Diego

Wed 10/21

12:04 pm-10:15 pm

1 stop8h 11m

Des Moines

Thu 12/3

5:15 pm-10:28 pm

1 stop7h 13m

$355

San DiegoDes Moines

SAN San Diego - DSM Des Moines

SANDSM

San Diego

Thu 11/26

6:15 am-2:08 pm

1 stop5h 53m

Des Moines

Tue 12/1

6:41 am-1:03 pm

1 stop8h 22m

$355

San DiegoDes Moines

SAN San Diego - DSM Des Moines

SANDSM

San Diego

Wed 10/21

7:00 am-4:20 pm

1 stop7h 20m

Des Moines

Tue 11/3

5:30 am-11:31 am

2 stops8h 01m

$360

San DiegoDes Moines

SAN San Diego - DSM Des Moines

SANDSM

San Diego

Thu 11/26

6:25 am-2:37 pm

1 stop6h 12m

Des Moines

Tue 12/1

5:00 am-8:40 am

1 stop5h 40m

$393
Quickest round-trip

San DiegoDes Moines

SAN San Diego - DSM Des Moines

SANDSM

San Diego

Mon 11/23

6:15 am-2:08 pm

1 stop5h 53m

Des Moines

Mon 11/30

7:55 pm-11:53 pm

1 stop5h 58m

$426

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Des Moines from

How to get the cheapest flight ticket from San Diego to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Diego and Des Moines?

Prices are currently low for flights on this route.

Typical prices usually range from $268 to $395.
The lowest price recently found on this route was $211.

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in November, then February is your next best option. Flight prices from San Diego to Des Moines during February average around $362.

Can stopping save me money on San Diego to Des Moines flights?

No. A direct flight is the cheapest option for a flight between San Diego to Des Moines.

How have San Diego to Des Moines flight prices changed over time?

As of September 2026, prices for San Diego to Des Moines flights are approximately 55% cheaper when compared to flights at the same time last year.

When to book flights from San Diego to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to Des Moines (SAN to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Des Moines

Best Price Found

$135

Fastest flight time

5h 37m

Direct flights

None
The best one-way flight to Des Moines from San Diego in the past 72 hours is $135. The best round-trip flight deal from San Diego to Des Moines found on momondo in the last 72 hours is $211.
The fastest flight from San Diego to Des Moines takes 5h 37m
There are no direct flights from San Diego to Des Moines. There are no popular flight routes from San Diego to Des Moines.
Search flight deals

Frequently asked questions about flying from San Diego to Des Moines

  • How far is San Diego to Des Moines by plane?

    San Diego and Des Moines are 1426.2 mi apart from one another. Typically, this will take 5h 37m by plane in normal conditions.

  • When did momondo last update prices for flights from San Diego Airport to Des Moines Airport?

    Prices for flights from San Diego Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from San Diego Airport to Des Moines Airport?

  • How old do you have to be to fly from San Diego Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Diego Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from San Diego to Des Moines?

  • What is the most popular airline from San Diego to Des Moines?

Best airlines flying from San Diego to Des Moines

Compare and see reviews for airlines that fly from San Diego to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $148Free CancellationRating
7.8
8,538 reviews
Search Delta flights
FrontierPriceFrom $158Free CancellationRating
5.6
2,629 reviews
Search Frontier flights
American AirlinesPriceFrom $208Free CancellationRating
7.1
12,023 reviews
Search American Airlines flights
United AirlinesPriceFrom $296Free CancellationRating
7.4
10,157 reviews
Search United Airlines flights
SouthwestPriceFrom $310Free CancellationRating
8.0
4,191 reviews
Search Southwest flights

  • United Airlines Flights From San Diego to Des Moines

    The lowest priced United Airlines flight from San Diego to Des Moines from the last 72 hours was $296. Generally, United Airlines has 1 flight on this route every week with an average price of $395. United Airlines is rated 7.4/10 by our users.

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Clive
Altoona
Pella
Urbandale
Newton
Osceola
Boone
Johnston
Oskaloosa
Norwalk
Grinnell
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from San Diego to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from San Diego to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from San Diego on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Diego to Des Moines?

momondo helps you find the best flight between San Diego and Des Moines by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from San Diego to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from San Diego are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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