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Cheap flights from San Diego to Des Moines from $138

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to Des Moines departing on 4/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Diego to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
6:25 am - 7:14 pm
SAN
-
DSM
10h 49m
1 stop
Frontier Logo
8:14 pm - 8:04 pm
DSM
-
SAN
25h 50m
1 stop
$235Frontier
Fri, Apr 10 - Mon, Apr 13
Frontier Logo
6:25 am - 7:14 pm
SAN
-
DSM
10h 49m
1 stop
Frontier Logo
8:14 pm - 12:02 am
DSM
-
SAN
5h 48m
1 stop
$260Frontier
Fri, Apr 10 - Mon, Apr 13
Multiple Airlines Logo
8:10 am - 9:21 pm
SAN
-
DSM
11h 11m
2 stops
Multiple Airlines Logo
8:14 pm - 8:04 pm
DSM
-
SAN
25h 50m
1 stop
$265Multiple Airlines
Fri, Apr 10 - Mon, Apr 13
Multiple Airlines Logo
6:25 am - 1:09 pm
SAN
-
DSM
28h 44m
1 stop
Multiple Airlines Logo
2:51 pm - 8:34 am
DSM
-
SAN
19h 43m
2 stops
$266Multiple Airlines
Thu, Apr 30 - Sun, May 3
Frontier Logo
9:37 am - 1:31 pm
SAN
-
DSM
25h 54m
1 stop
Frontier Logo
2:16 pm - 11:50 pm
DSM
-
SAN
11h 34m
1 stop
$273Frontier
Thu, May 21 - Wed, Jun 3
Frontier Logo
6:25 am - 7:14 pm
SAN
-
DSM
10h 49m
1 stop
Frontier Logo
8:14 pm - 8:04 pm
DSM
-
SAN
25h 50m
1 stop
$276Frontier
Fri, Apr 10 - Mon, Apr 13
Multiple Airlines Logo
12:36 pm - 1:29 pm
SAN
-
DSM
22h 53m
1 stop
Multiple Airlines Logo
2:51 pm - 2:25 pm
DSM
-
SAN
25h 34m
2 stops
$279Multiple Airlines
Thu, May 7 - Sun, May 10
Frontier Logo
6:25 am - 7:16 pm
SAN
-
DSM
10h 51m
1 stop
Frontier Logo
8:14 pm - 3:36 pm
DSM
-
SAN
21h 22m
1 stop
$285Frontier
Mon, Mar 30 - Mon, Apr 6
Multiple Airlines Logo
6:25 am - 7:26 pm
SAN
-
DSM
11h 01m
1 stop
Multiple Airlines Logo
10:01 pm - 6:37 pm
DSM
-
SAN
22h 36m
1 stop
$288Multiple Airlines
Wed, Jul 22 - Fri, Jul 31
Multiple Airlines Logo
12:36 pm - 1:29 pm
SAN
-
DSM
22h 53m
1 stop
Multiple Airlines Logo
2:51 pm - 2:25 pm
DSM
-
SAN
25h 34m
2 stops
$290Multiple Airlines
Thu, May 7 - Sun, May 10

Southwest flights from San Diego to Des Moines

Our best Southwest deals on San Diego to Des Moines flight tickets
Southwest
May 9
SAN8:35 amSan Diego
7h 25m
1 stop
DSM6:00 pmDes Moines
May 13
DSM6:55 amDes Moines
7h 10m
1 stop
SAN12:05 pmSan Diego
$317
Southwest
May 9
SAN8:35 amSan Diego
7h 25m
1 stop
DSM6:00 pmDes Moines
May 13
DSM6:55 amDes Moines
7h 15m
2 stops
SAN12:10 pmSan Diego
$322
Southwest
May 9
SAN10:25 amSan Diego
8h 30m
2 stops
DSM8:55 pmDes Moines
May 13
DSM6:55 amDes Moines
7h 45m
2 stops
SAN12:40 pmSan Diego
$327

United Airlines flights from San Diego to Des Moines

Our best United Airlines deals on San Diego to Des Moines flight tickets
United Airlines
May 6
SAN12:10 pmSan Diego
8h 35m
1 stop
DSM10:45 pmDes Moines
May 9
DSM5:30 amDes Moines
5h 45m
1 stop
SAN9:15 amSan Diego
$337
United Airlines
May 6
SAN12:40 pmSan Diego
5h 36m
1 stop
DSM8:16 pmDes Moines
May 9
DSM5:17 pmDes Moines
8h 42m
2 stops
SAN11:59 pmSan Diego
$342
United Airlines
May 23
SAN11:44 amSan Diego
10h 00m
2 stops
DSM11:44 pmDes Moines
May 26
DSM5:50 amDes Moines
5h 15m
1 stop
SAN9:05 amSan Diego
$373

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 13, 2026.
Use the filters below to find and compare flights from San Diego to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Fri 4/10

6:25 am-7:14 pm

1 stop10h 49m

Des Moines

Mon 4/13

8:14 pm-8:04 pm

1 stop25h 50m

$235
Quickest round-trip

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Fri 4/10

6:25 am-7:14 pm

1 stop10h 49m

Des Moines

Mon 4/13

8:14 pm-12:02 am

1 stop5h 48m

$260

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Fri 4/10

8:10 am-9:21 pm

2 stops11h 11m

Des Moines

Mon 4/13

8:14 pm-8:04 pm

1 stop25h 50m

$265

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Thu 4/30

6:25 am-1:09 pm

1 stop28h 44m

Des Moines

Sun 5/3

2:51 pm-8:34 am

2 stops19h 43m

$266

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Thu 5/21

9:37 am-1:31 pm

1 stop25h 54m

Des Moines

Wed 6/3

2:16 pm-11:50 pm

1 stop11h 34m

$273

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Fri 4/10

6:25 am-7:14 pm

1 stop10h 49m

Des Moines

Mon 4/13

8:14 pm-8:04 pm

1 stop25h 50m

$276

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Thu 5/7

12:36 pm-1:29 pm

1 stop22h 53m

Des Moines

Sun 5/10

2:51 pm-2:25 pm

2 stops25h 34m

$279

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Mon 3/30

6:25 am-7:16 pm

1 stop10h 51m

Des Moines

Mon 4/6

8:14 pm-3:36 pm

1 stop21h 22m

$285

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Wed 7/22

6:25 am-7:26 pm

1 stop11h 01m

Des Moines

Fri 7/31

10:01 pm-6:37 pm

1 stop22h 36m

$288

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Thu 5/7

12:36 pm-1:29 pm

1 stop22h 53m

Des Moines

Sun 5/10

2:51 pm-2:25 pm

2 stops25h 34m

$290

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from San Diego to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in November, then May is your next best option. Flight prices from San Diego to Des Moines during May average around $312.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from San Diego to Des Moines is on a Sunday. Travelers who choose to depart for Des Moines on a Sunday will often find tickets for as low as $140. Flights from San Diego to Des Moines on a Monday will generally be more expensive and average around $171. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest San Diego to Des Moines flight route?

Fly from San Diego to Des Moines for the best San Diego - Des Moines flight prices

What cabin class options are available on San Diego to Des Moines flights?

There is only 1 cabin class available to choose from on San Diego to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on San Diego to Des Moines flights?

No. A direct flight is the cheapest option for a flight between San Diego to Des Moines.

How have San Diego to Des Moines flight prices changed over time?

As of March 2026, prices for San Diego to Des Moines flights are approximately 22% cheaper when compared to flights at the same time last year.

When to book flights from San Diego to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to Des Moines (SAN to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Des Moines

Fastest flight time

5h 06m

Direct flights

None
The fastest flight from San Diego to Des Moines takes 5h 06m
There are no direct flights from San Diego to Des Moines. There are no popular flight routes from San Diego to Des Moines.
Search flight deals

  • How far is San Diego to Des Moines by plane?

    San Diego and Des Moines are 1426.2 mi apart from one another. Typically, this will take 5h 06m by plane in normal conditions.

  • When did momondo last update prices for flights from San Diego Airport to Des Moines Airport?

    Prices for flights from San Diego Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from San Diego Airport to Des Moines Airport?

  • How old do you have to be to fly from San Diego Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Diego Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from San Diego to Des Moines?

  • What is the most popular airline from San Diego to Des Moines?

Best airlines flying from San Diego to Des Moines

Compare and see reviews for airlines that fly from San Diego to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $69Free CancellationRating
7.3
714 reviews
Search Allegiant Air flights
FrontierPriceFrom $95Free CancellationRating
5.7
3,031 reviews
Search Frontier flights
DeltaPriceFrom $148Free CancellationRating
7.9
8,284 reviews
Search Delta flights
SouthwestPriceFrom $247Free CancellationRating
8.0
4,319 reviews
Search Southwest flights
United AirlinesPriceFrom $286Free CancellationRating
7.4
9,418 reviews
Search United Airlines flights
American AirlinesPriceFrom $286Free CancellationRating
7.1
11,433 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from San Diego to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from San Diego to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from San Diego on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Diego to Des Moines?

momondo helps you find the best flight between San Diego and Des Moines by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from San Diego to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from San Diego are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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