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Cheap flights from San Diego to Des Moines from $111

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to Des Moines departing on 5/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Diego to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
6:25 am - 1:31 pm
SAN
-
DSM
5h 06m
1 stop
Frontier Logo
2:16 pm - 11:50 pm
DSM
-
SAN
11h 34m
1 stop
$210Frontier
Mon, Jun 1 - Mon, Jun 8
Frontier Logo
6:25 am - 1:31 pm
SAN
-
DSM
5h 06m
1 stop
Frontier Logo
2:16 pm - 11:50 pm
DSM
-
SAN
11h 34m
1 stop
$230Frontier
Mon, Jun 1 - Mon, Jun 8
Multiple Airlines Logo
10:07 pm - 8:11 pm
SAN
-
DSM
20h 04m
1 stop
Multiple Airlines Logo
8:36 pm - 9:12 pm
DSM
-
SAN
26h 36m
1 stop
$262Multiple Airlines
Wed, Jun 3 - Sun, Jun 7
Frontier Logo
6:25 am - 1:31 pm
SAN
-
DSM
5h 06m
1 stop
Frontier Logo
2:16 pm - 11:53 pm
DSM
-
SAN
11h 37m
1 stop
$270Frontier
Fri, Jun 12 - Mon, Jun 15
Multiple Airlines Logo
8:29 pm - 9:06 pm
SAN
-
DSM
22h 37m
1 stop
Multiple Airlines Logo
9:56 pm - 8:58 pm
DSM
-
SAN
25h 02m
1 stop
$272Multiple Airlines
Thu, Jun 11 - Mon, Jun 15
Frontier Logo
6:25 am - 1:31 pm
SAN
-
DSM
5h 06m
1 stop
Frontier Logo
2:16 pm - 11:50 pm
DSM
-
SAN
11h 34m
1 stop
$290Frontier
Fri, May 22 - Mon, May 25
Multiple Airlines Logo
6:25 am - 1:31 pm
SAN
-
DSM
29h 06m
1 stop
Multiple Airlines Logo
11:00 am - 12:43 pm
DSM
-
SAN
27h 43m
2 stops
$296Multiple Airlines
Thu, May 7 - Sun, May 10
Multiple Airlines Logo
8:29 pm - 1:31 pm
SAN
-
DSM
15h 02m
2 stops
Multiple Airlines Logo
9:56 pm - 8:58 pm
DSM
-
SAN
25h 02m
1 stop
$302Multiple Airlines
Thu, Jun 11 - Mon, Jun 15
Multiple Airlines Logo
10:07 pm - 8:11 pm
SAN
-
DSM
20h 04m
1 stop
Multiple Airlines Logo
10:53 am - 8:42 am
DSM
-
SAN
23h 49m
2 stops
$311Multiple Airlines
Wed, Jun 3 - Sun, Jun 7
Multiple Airlines Logo
9:53 pm - 10:30 pm
SAN
-
DSM
22h 37m
2 stops
Multiple Airlines Logo
9:44 pm - 8:58 pm
DSM
-
SAN
25h 14m
1 stop
$312Multiple Airlines
Sun, Aug 2 - Sun, Aug 16

Frontier flights from San Diego to Des Moines

Our best Frontier deals on San Diego to Des Moines flight tickets
Frontier
Jun 1
SAN6:25 amSan Diego
5h 06m
1 stop
DSM1:31 pmDes Moines
Jun 8
DSM2:16 pmDes Moines
11h 34m
1 stop
SAN11:50 pmSan Diego
$210
Frontier
Jun 1
SAN6:25 amSan Diego
5h 06m
1 stop
DSM1:31 pmDes Moines
Jun 8
DSM2:16 pmDes Moines
11h 34m
1 stop
SAN11:50 pmSan Diego
$230
Frontier
Jun 12
SAN6:25 amSan Diego
5h 06m
1 stop
DSM1:31 pmDes Moines
Jun 15
DSM2:16 pmDes Moines
11h 37m
1 stop
SAN11:53 pmSan Diego
$270

American Airlines flights from San Diego to Des Moines

Our best American Airlines deals on San Diego to Des Moines flight tickets
American Airlines
Jun 2
SAN6:15 amSan Diego
7h 48m
1 stop
DSM4:03 pmDes Moines
Jun 9
DSM7:02 pmDes Moines
6h 57m
1 stop
SAN11:59 pmSan Diego
$337
American Airlines
May 28
SAN1:19 pmSan Diego
8h 49m
1 stop
DSM12:08 amDes Moines
Jun 1
DSM6:47 pmDes Moines
7h 12m
1 stop
SAN11:59 pmSan Diego
$367
American Airlines
May 28
SAN3:10 pmSan Diego
6h 47m
1 stop
DSM11:57 pmDes Moines
May 29
DSM5:45 amDes Moines
5h 12m
1 stop
SAN8:57 amSan Diego
$377

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 14, 2026.
Use the filters below to find and compare flights from San Diego to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Mon 6/1

6:25 am-1:31 pm

1 stop5h 06m

Des Moines

Mon 6/8

2:16 pm-11:50 pm

1 stop11h 34m

$210

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Mon 6/1

6:25 am-1:31 pm

1 stop5h 06m

Des Moines

Mon 6/8

2:16 pm-11:50 pm

1 stop11h 34m

$230

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Wed 6/3

10:07 pm-8:11 pm

1 stop20h 04m

Des Moines

Sun 6/7

8:36 pm-9:12 pm

1 stop26h 36m

$262

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Fri 6/12

6:25 am-1:31 pm

1 stop5h 06m

Des Moines

Mon 6/15

2:16 pm-11:53 pm

1 stop11h 37m

$270

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Thu 6/11

8:29 pm-9:06 pm

1 stop22h 37m

Des Moines

Mon 6/15

9:56 pm-8:58 pm

1 stop25h 02m

$272

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Fri 5/22

6:25 am-1:31 pm

1 stop5h 06m

Des Moines

Mon 5/25

2:16 pm-11:50 pm

1 stop11h 34m

$290

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Thu 5/7

6:25 am-1:31 pm

1 stop29h 06m

Des Moines

Sun 5/10

11:00 am-12:43 pm

2 stops27h 43m

$296

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Thu 6/11

8:29 pm-1:31 pm

2 stops15h 02m

Des Moines

Mon 6/15

9:56 pm-8:58 pm

1 stop25h 02m

$302

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Wed 6/3

10:07 pm-8:11 pm

1 stop20h 04m

Des Moines

Sun 6/7

10:53 am-8:42 am

2 stops23h 49m

$311

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Sun 8/2

9:53 pm-10:30 pm

2 stops22h 37m

Des Moines

Sun 8/16

9:44 pm-8:58 pm

1 stop25h 14m

$312

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from San Diego to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Diego and Des Moines?

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in November, then July is your next best option. Flight prices from San Diego to Des Moines during July average around $303.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from San Diego to Des Moines is on a Sunday. Travelers who choose to depart for Des Moines on a Sunday will often find tickets for as low as $140. Flights from San Diego to Des Moines on a Monday will generally be more expensive and average around $171. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest San Diego to Des Moines flight route?

Fly from San Diego to Des Moines for the best San Diego - Des Moines flight prices

What cabin class options are available on San Diego to Des Moines flights?

There is only 1 cabin class available to choose from on San Diego to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on San Diego to Des Moines flights?

No. A direct flight is the cheapest option for a flight between San Diego to Des Moines.

How have San Diego to Des Moines flight prices changed over time?

As of April 2026, prices for San Diego to Des Moines flights are approximately 114% more expensive when compared to flights at the same time last year.

When to book flights from San Diego to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to Des Moines (SAN to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Des Moines

Fastest flight time

5h 06m

Direct flights

None
The fastest flight from San Diego to Des Moines takes 5h 06m
There are no direct flights from San Diego to Des Moines. There are no popular flight routes from San Diego to Des Moines.
Search flight deals

Frequently asked questions about flying from San Diego to Des Moines

  • How far is San Diego to Des Moines by plane?

    San Diego and Des Moines are 1426.2 mi apart from one another. Typically, this will take 5h 06m by plane in normal conditions.

  • When did momondo last update prices for flights from San Diego Airport to Des Moines Airport?

    Prices for flights from San Diego Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from San Diego Airport to Des Moines Airport?

  • How old do you have to be to fly from San Diego Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Diego Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from San Diego to Des Moines?

  • What is the most popular airline from San Diego to Des Moines?

Best airlines flying from San Diego to Des Moines

Compare and see reviews for airlines that fly from San Diego to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $69Free CancellationRating
7.3
707 reviews
Search Allegiant Air flights
DeltaPriceFrom $148Free CancellationRating
7.9
8,406 reviews
Search Delta flights
FrontierPriceFrom $158Free CancellationRating
5.6
2,995 reviews
Search Frontier flights
SouthwestPriceFrom $247Free CancellationRating
8.0
4,328 reviews
Search Southwest flights
United AirlinesPriceFrom $286Free CancellationRating
7.4
9,581 reviews
Search United Airlines flights
American AirlinesPriceFrom $286Free CancellationRating
7.1
11,573 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from San Diego to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from San Diego to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from San Diego on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Diego to Des Moines?

momondo helps you find the best flight between San Diego and Des Moines by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from San Diego to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from San Diego are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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