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Cheap flights from San Diego to Des Moines from $117

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to Des Moines departing on 1/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Diego to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:36 am - 7:22 pm
SAN
-
DSM
10h 46m1 stop
Multiple Airlines Logo
4:30 pm - 7:31 pm
DSM
-
SAN
29h 01m1 stop
$192Multiple Airlines
lun., ene. 12 - dom., ene. 18
Multiple Airlines Logo
6:36 am - 7:22 pm
SAN
-
DSM
10h 46m1 stop
Multiple Airlines Logo
8:30 am - 10:13 am
DSM
-
SAN
27h 43m2 stops
$209Multiple Airlines
lun., ene. 12 - dom., ene. 18
Frontier Logo
4:47 pm - 7:44 pm
SAN
-
DSM
24h 57m1 stop
Frontier Logo
8:29 pm - 11:59 pm
DSM
-
SAN
5h 30m1 stop
$245Frontier
jue., ene. 1 - lun., ene. 5
Frontier Logo
6:25 am - 7:44 pm
SAN
-
DSM
11h 19m1 stop
Frontier Logo
8:17 pm - 11:59 pm
DSM
-
SAN
5h 42m1 stop
$302Frontier
vie., ene. 2 - vie., ene. 9
Southwest Logo
7:30 am - 4:00 pm
SAN
-
DSM
6h 30m1 stop
Southwest Logo
12:05 pm - 3:55 pm
DSM
-
SAN
5h 50m1 stop
$316Southwest
jue., feb. 5 - mar., feb. 10
Southwest Logo
12:15 pm - 10:15 pm
SAN
-
DSM
8h 00m1 stop
Southwest Logo
8:35 am - 4:45 pm
DSM
-
SAN
10h 10m2 stops
$321Southwest
jue., feb. 5 - mar., feb. 10
Southwest Logo
11:20 am - 9:20 pm
SAN
-
DSM
8h 00m2 stops
Southwest Logo
8:35 am - 4:45 pm
DSM
-
SAN
10h 10m2 stops
$326Southwest
jue., feb. 5 - mar., feb. 10
Frontier Logo
9:14 pm - 7:44 pm
SAN
-
DSM
20h 30m2 stops
Frontier Logo
8:29 pm - 11:16 pm
DSM
-
SAN
28h 47m1 stop
$372Frontier
jue., ene. 1 - lun., ene. 5
Southwest Logo
9:40 am - 7:20 pm
SAN
-
DSM
7h 40m2 stops
Southwest Logo
8:35 am - 4:45 pm
DSM
-
SAN
10h 10m2 stops
$388Southwest
lun., ene. 12 - dom., ene. 18
Delta Logo
10:10 pm - 9:35 am
SAN
-
DSM
9h 25m1 stop
Delta Logo
5:20 pm - 11:09 pm
DSM
-
SAN
7h 49m1 stop
$397Delta
lun., mar. 30 - mar., abr. 7

Southwest flights from San Diego to Des Moines

Our best Southwest deals on San Diego to Des Moines flight tickets
Southwest
Feb 5
SAN7:30 amSan Diego
6h 30m
1 stop
DSM4:00 pmDes Moines
Feb 10
DSM12:05 pmDes Moines
5h 50m
1 stop
SAN3:55 pmSan Diego
$316
Find similar
Southwest
Feb 5
SAN12:15 pmSan Diego
8h 00m
1 stop
DSM10:15 pmDes Moines
Feb 10
DSM8:35 amDes Moines
10h 10m
2 stops
SAN4:45 pmSan Diego
$321
Find similar
Southwest
Feb 5
SAN11:20 amSan Diego
8h 00m
2 stops
DSM9:20 pmDes Moines
Feb 10
DSM8:35 amDes Moines
10h 10m
2 stops
SAN4:45 pmSan Diego
$326
Find similar

United Airlines flights from San Diego to Des Moines

Our best United Airlines deals on San Diego to Des Moines flight tickets
United Airlines
May 16
SAN6:32 amSan Diego
7h 42m
1 stop
DSM4:14 pmDes Moines
May 21
DSM6:25 amDes Moines
6h 57m
1 stop
SAN11:22 amSan Diego
$427
Find similar
United Airlines
May 16
SAN10:55 amSan Diego
10h 44m
2 stops
DSM11:39 pmDes Moines
May 21
DSM6:25 amDes Moines
6h 57m
1 stop
SAN11:22 amSan Diego
$432
Find similar
United Airlines
Jan 8
SAN10:52 amSan Diego
8h 58m
1 stop
DSM9:50 pmDes Moines
Jan 12
DSM3:04 pmDes Moines
8h 52m
1 stop
SAN9:56 pmSan Diego
$435
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated diciembre 11, 2025.
Use the filters below to find and compare flights from San Diego to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

lun. 1/12

6:36 am-7:22 pm

1 stop10h 46m

Des Moines

dom. 1/18

4:30 pm-7:31 pm

1 stop29h 01m

$192

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

lun. 1/12

6:36 am-7:22 pm

1 stop10h 46m

Des Moines

dom. 1/18

8:30 am-10:13 am

2 stops27h 43m

$209

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

jue. 1/1

4:47 pm-7:44 pm

1 stop24h 57m

Des Moines

lun. 1/5

8:29 pm-11:59 pm

1 stop5h 30m

$245

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

vie. 1/2

6:25 am-7:44 pm

1 stop11h 19m

Des Moines

vie. 1/9

8:17 pm-11:59 pm

1 stop5h 42m

$302

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

jue. 2/5

7:30 am-4:00 pm

1 stop6h 30m

Des Moines

mar. 2/10

12:05 pm-3:55 pm

1 stop5h 50m

$316

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

jue. 2/5

12:15 pm-10:15 pm

1 stop8h 00m

Des Moines

mar. 2/10

8:35 am-4:45 pm

2 stops10h 10m

$321

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

jue. 2/5

11:20 am-9:20 pm

2 stops8h 00m

Des Moines

mar. 2/10

8:35 am-4:45 pm

2 stops10h 10m

$326

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

jue. 1/1

9:14 pm-7:44 pm

2 stops20h 30m

Des Moines

lun. 1/5

8:29 pm-11:16 pm

1 stop28h 47m

$372

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

lun. 1/12

9:40 am-7:20 pm

2 stops7h 40m

Des Moines

dom. 1/18

8:35 am-4:45 pm

2 stops10h 10m

$388

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

lun. 3/30

10:10 pm-9:35 am

1 stop9h 25m

Des Moines

mar. 4/7

5:20 pm-11:09 pm

1 stop7h 49m

$397

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from San Diego to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in November, then July is your next best option. Flight prices from San Diego to Des Moines during July average around $329.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from San Diego to Des Moines is on a Sunday. Travelers who choose to depart for Des Moines on a Sunday will often find tickets for as low as $140. Flights from San Diego to Des Moines on a Wednesday will generally be more expensive and average around $436. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the afternoon. momondo users have found flights departing from San Diego to Des Moines in the afternoon for as low as $171. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the evening because they tend to be around $562. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest San Diego to Des Moines flight route?

Fly from San Diego to Des Moines for the best San Diego - Des Moines flight prices

What cabin class options are available on San Diego to Des Moines flights?

There is only 1 cabin class available to choose from on San Diego to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on San Diego to Des Moines flights?

You could potentially save up to 24% on your flight if you consider stops on a San Diego to Des Moines flight.

How have San Diego to Des Moines flight prices changed over time?

As of December 2025, prices for San Diego to Des Moines flights are approximately 9% cheaper when compared to flights at the same time last year.

When to book flights from San Diego to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to Des Moines (SAN to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Des Moines

Fastest flight time

5h 20m

Direct flights

None
The fastest flight from San Diego to Des Moines takes 5h 20m
There are no direct flights from San Diego to Des Moines. There are no popular flight routes from San Diego to Des Moines.
Search flight deals

  • How far is San Diego to Des Moines by plane?

    San Diego and Des Moines are 1426.2 mi apart from one another. Typically, this will take 5h 20m by plane in normal conditions.

  • When did momondo last update prices for flights from San Diego Airport to Des Moines Airport?

    Prices for flights from San Diego Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from San Diego Airport to Des Moines Airport?

  • How old do you have to be to fly from San Diego Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Diego Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from San Diego to Des Moines?

  • What is the most popular airline from San Diego to Des Moines?

Best airlines flying from San Diego to Des Moines

Compare and see reviews for airlines that fly from San Diego to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $75Free CancellationRating
7.2
699 reviews
Search Allegiant Air flights
DeltaPriceFrom $148Free CancellationRating
7.9
8,005 reviews
Search Delta flights
FrontierPriceFrom $162Free CancellationRating
5.8
3,084 reviews
Search Frontier flights
SouthwestPriceFrom $286Free CancellationRating
7.9
4,252 reviews
Search Southwest flights
United AirlinesPriceFrom $286Free CancellationRating
7.4
9,095 reviews
Search United Airlines flights
American AirlinesPriceFrom $286Free CancellationRating
7.2
11,049 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Urbandale
Clive
Pella
Newton
Johnston
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from San Diego to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from San Diego to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from San Diego on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Diego to Des Moines?

momondo helps you find the best flight between San Diego and Des Moines by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from San Diego to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from San Diego are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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