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Cheap flights from San Diego to Des Moines from $112

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to Des Moines departing on 2/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Diego to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
6:25 am - 6:19 pm
SAN
-
DSM
9h 54m1 stop
Frontier Logo
7:17 pm - 12:08 am
DSM
-
SAN
6h 51m1 stop
$154Frontier
Fri, Feb 13 - Mon, Feb 16
Multiple Airlines Logo
6:25 am - 7:04 pm
SAN
-
DSM
10h 39m1 stop
Multiple Airlines Logo
9:00 am - 1:57 pm
DSM
-
SAN
6h 57m1 stop
$164Multiple Airlines
Fri, Feb 27 - Sun, Mar 1
Multiple Airlines Logo
6:25 am - 7:04 pm
SAN
-
DSM
10h 39m1 stop
Multiple Airlines Logo
9:00 am - 1:05 pm
DSM
-
SAN
30h 05m2 stops
$183Multiple Airlines
Fri, Feb 27 - Sun, Mar 1
Frontier Logo
6:25 am - 6:19 pm
SAN
-
DSM
9h 54m1 stop
Frontier Logo
7:17 pm - 8:24 pm
DSM
-
SAN
27h 07m2 stops
$186Frontier
Fri, Feb 13 - Mon, Feb 16
Frontier Logo
12:23 pm - 6:32 pm
SAN
-
DSM
28h 09m1 stop
Frontier Logo
7:17 pm - 12:08 am
DSM
-
SAN
6h 51m1 stop
$191Frontier
Sat, Feb 14 - Mon, Feb 23
Multiple Airlines Logo
6:25 am - 6:19 pm
SAN
-
DSM
33h 54m2 stops
Multiple Airlines Logo
9:00 am - 1:57 pm
DSM
-
SAN
6h 57m1 stop
$205Multiple Airlines
Thu, Feb 19 - Sun, Feb 22
Multiple Airlines Logo
6:25 am - 2:19 pm
SAN
-
DSM
29h 54m2 stops
Multiple Airlines Logo
7:17 pm - 12:08 am
DSM
-
SAN
6h 51m1 stop
$208Multiple Airlines
Sat, Feb 14 - Mon, Feb 23
Frontier Logo
6:25 am - 6:47 pm
SAN
-
DSM
10h 22m1 stop
Frontier Logo
7:45 pm - 12:08 am
DSM
-
SAN
6h 23m1 stop
$215Frontier
Thu, Feb 19 - Sun, Feb 22
American Airlines Logo
10:35 pm - 8:54 am
SAN
-
DSM
8h 19m1 stop
American Airlines Logo
2:00 pm - 8:51 pm
DSM
-
SAN
8h 51m1 stop
$223American Airlines
Wed, Mar 25 - Tue, Mar 31
Southwest Logo
1:40 pm - 8:50 pm
SAN
-
DSM
5h 10m1 stop
Southwest Logo
6:55 am - 12:10 pm
DSM
-
SAN
7h 15m2 stops
$228Southwest
Tue, Mar 31 - Tue, Apr 7

American Airlines flights from San Diego to Des Moines

Our best American Airlines deals on San Diego to Des Moines flight tickets
American Airlines
Mar 25
SAN10:35 pmSan Diego
8h 19m
1 stop
DSM8:54 amDes Moines
Mar 31
DSM2:00 pmDes Moines
8h 51m
1 stop
SAN8:51 pmSan Diego
$223
American Airlines
Feb 12
SAN3:19 pmSan Diego
6h 21m
1 stop
DSM11:40 pmDes Moines
Feb 17
DSM1:38 pmDes Moines
8h 42m
1 stop
SAN8:20 pmSan Diego
$271
American Airlines
Mar 30
SAN10:35 pmSan Diego
8h 14m
1 stop
DSM8:49 amDes Moines
Apr 7
DSM1:38 pmDes Moines
8h 31m
1 stop
SAN8:09 pmSan Diego
$322

United Airlines flights from San Diego to Des Moines

Our best United Airlines deals on San Diego to Des Moines flight tickets
United Airlines
Feb 5
SAN12:11 pmSan Diego
8h 19m
1 stop
DSM10:30 pmDes Moines
Feb 10
DSM5:09 pmDes Moines
5h 33m
1 stop
SAN8:42 pmSan Diego
$247
United Airlines
Feb 5
SAN12:11 pmSan Diego
8h 19m
1 stop
DSM10:30 pmDes Moines
Feb 10
DSM5:09 pmDes Moines
8h 33m
2 stops
SAN11:42 pmSan Diego
$252
United Airlines
Feb 12
SAN11:05 amSan Diego
7h 02m
2 stops
DSM8:07 pmDes Moines
Feb 17
DSM3:24 pmDes Moines
9h 20m
1 stop
SAN10:44 pmSan Diego
$308

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 8, 2026.
Use the filters below to find and compare flights from San Diego to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Fri 2/13

6:25 am-6:19 pm

1 stop9h 54m

Des Moines

Mon 2/16

7:17 pm-12:08 am

1 stop6h 51m

$154

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Fri 2/27

6:25 am-7:04 pm

1 stop10h 39m

Des Moines

Sun 3/1

9:00 am-1:57 pm

1 stop6h 57m

$164

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Fri 2/27

6:25 am-7:04 pm

1 stop10h 39m

Des Moines

Sun 3/1

9:00 am-1:05 pm

2 stops30h 05m

$183

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Fri 2/13

6:25 am-6:19 pm

1 stop9h 54m

Des Moines

Mon 2/16

7:17 pm-8:24 pm

2 stops27h 07m

$186

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Sat 2/14

12:23 pm-6:32 pm

1 stop28h 09m

Des Moines

Mon 2/23

7:17 pm-12:08 am

1 stop6h 51m

$191

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Thu 2/19

6:25 am-6:19 pm

2 stops33h 54m

Des Moines

Sun 2/22

9:00 am-1:57 pm

1 stop6h 57m

$205

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Sat 2/14

6:25 am-2:19 pm

2 stops29h 54m

Des Moines

Mon 2/23

7:17 pm-12:08 am

1 stop6h 51m

$208

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Thu 2/19

6:25 am-6:47 pm

1 stop10h 22m

Des Moines

Sun 2/22

7:45 pm-12:08 am

1 stop6h 23m

$215

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Wed 3/25

10:35 pm-8:54 am

1 stop8h 19m

Des Moines

Tue 3/31

2:00 pm-8:51 pm

1 stop8h 51m

$223

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Tue 3/31

1:40 pm-8:50 pm

1 stop5h 10m

Des Moines

Tue 4/7

6:55 am-12:10 pm

2 stops7h 15m

$228

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from San Diego to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in November, then July is your next best option. Flight prices from San Diego to Des Moines during July average around $328.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from San Diego to Des Moines is on a Sunday. Travelers who choose to depart for Des Moines on a Sunday will often find tickets for as low as $140. Flights from San Diego to Des Moines on a Monday will generally be more expensive and average around $171. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest San Diego to Des Moines flight route?

Fly from San Diego to Des Moines for the best San Diego - Des Moines flight prices

How far in advance should I book a flight to Des Moines?

You are more likely to see cheaper flights to Des Moines from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to Des Moines for around $387 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Des Moines from San Diego for as low as $164 on momondo.

What cabin class options are available on San Diego to Des Moines flights?

There is only 1 cabin class available to choose from on San Diego to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on San Diego to Des Moines flights?

No. A direct flight is the cheapest option for a flight between San Diego to Des Moines.

How have San Diego to Des Moines flight prices changed over time?

As of January 2026, prices for San Diego to Des Moines flights are approximately 10% cheaper when compared to flights at the same time last year.

When to book flights from San Diego to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to Des Moines (SAN to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Des Moines

Fastest flight time

5h 15m

Direct flights

None
The fastest flight from San Diego to Des Moines takes 5h 15m
There are no direct flights from San Diego to Des Moines. There are no popular flight routes from San Diego to Des Moines.
Search flight deals

  • How far is San Diego to Des Moines by plane?

    San Diego and Des Moines are 1426.2 mi apart from one another. Typically, this will take 5h 15m by plane in normal conditions.

  • When did momondo last update prices for flights from San Diego Airport to Des Moines Airport?

    Prices for flights from San Diego Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from San Diego Airport to Des Moines Airport?

  • How old do you have to be to fly from San Diego Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Diego Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from San Diego to Des Moines?

  • What is the most popular airline from San Diego to Des Moines?

Best airlines flying from San Diego to Des Moines

Compare and see reviews for airlines that fly from San Diego to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $75Free CancellationRating
7.2
702 reviews
Search Allegiant Air flights
DeltaPriceFrom $148Free CancellationRating
7.9
8,032 reviews
Search Delta flights
FrontierPriceFrom $162Free CancellationRating
5.7
3,061 reviews
Search Frontier flights
SouthwestPriceFrom $286Free CancellationRating
8.0
4,250 reviews
Search Southwest flights
United AirlinesPriceFrom $286Free CancellationRating
7.4
9,143 reviews
Search United Airlines flights
American AirlinesPriceFrom $286Free CancellationRating
7.2
11,097 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Urbandale
Clive
Pella
Newton
Johnston
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from San Diego to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from San Diego to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from San Diego on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Diego to Des Moines?

momondo helps you find the best flight between San Diego and Des Moines by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from San Diego to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from San Diego are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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