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Cheap flights from San Diego to Des Moines from $105

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to Des Moines departing on 2/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Diego to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
6:25 am - 6:47 pm
SAN
-
DSM
10h 22m
1 stop
Frontier Logo
7:17 pm - 12:08 am
DSM
-
SAN
6h 51m
1 stop
$166Frontier
Thu, Feb 12 - Fri, Feb 13
Frontier Logo
6:25 am - 6:47 pm
SAN
-
DSM
10h 22m
1 stop
Frontier Logo
7:17 pm - 12:08 am
DSM
-
SAN
6h 51m
1 stop
$169Frontier
Thu, Feb 12 - Fri, Feb 13
Frontier Logo
6:25 am - 6:47 pm
SAN
-
DSM
10h 22m
1 stop
Frontier Logo
7:17 pm - 12:08 am
DSM
-
SAN
6h 51m
1 stop
$180Frontier
Thu, Feb 19 - Mon, Feb 23
Frontier Logo
6:25 am - 6:47 pm
SAN
-
DSM
10h 22m
1 stop
Frontier Logo
7:17 pm - 7:53 pm
DSM
-
SAN
26h 36m
2 stops
$198Frontier
Thu, Feb 12 - Fri, Feb 13
Multiple Airlines Logo
12:00 pm - 8:13 pm
SAN
-
DSM
30h 13m
2 stops
Multiple Airlines Logo
7:58 pm - 12:01 am
DSM
-
SAN
6h 03m
1 stop
$228Multiple Airlines
Wed, Apr 8 - Mon, Apr 13
Frontier Logo
6:25 am - 6:47 pm
SAN
-
DSM
10h 22m
1 stop
Frontier Logo
7:45 pm - 12:08 am
DSM
-
SAN
6h 23m
1 stop
$235Frontier
Thu, Feb 19 - Sun, Feb 22
Frontier Logo
8:00 am - 6:32 pm
SAN
-
DSM
32h 32m
2 stops
Frontier Logo
7:17 pm - 12:08 am
DSM
-
SAN
6h 51m
1 stop
$250Frontier
Sat, Feb 14 - Mon, Feb 16
Frontier Logo
12:23 pm - 6:32 pm
SAN
-
DSM
28h 09m
1 stop
Frontier Logo
7:17 pm - 12:08 am
DSM
-
SAN
6h 51m
1 stop
$259Frontier
Sat, Feb 14 - Mon, Feb 16
Multiple Airlines Logo
9:56 pm - 6:46 pm
SAN
-
DSM
18h 50m
2 stops
Multiple Airlines Logo
11:00 am - 4:15 pm
DSM
-
SAN
31h 15m
1 stop
$298Multiple Airlines
Sun, Apr 5 - Sun, Apr 12
Multiple Airlines Logo
9:56 pm - 8:55 pm
SAN
-
DSM
20h 59m
1 stop
Multiple Airlines Logo
11:00 am - 4:15 pm
DSM
-
SAN
31h 15m
1 stop
$309Multiple Airlines
Sun, Apr 5 - Sun, Apr 12

Frontier flights from San Diego to Des Moines

Our best Frontier deals on San Diego to Des Moines flight tickets
Frontier
Feb 12
SAN6:25 amSan Diego
10h 22m
1 stop
DSM6:47 pmDes Moines
Feb 13
DSM7:17 pmDes Moines
6h 51m
1 stop
SAN12:08 amSan Diego
$166
Frontier
Feb 12
SAN6:25 amSan Diego
10h 22m
1 stop
DSM6:47 pmDes Moines
Feb 13
DSM7:17 pmDes Moines
6h 51m
1 stop
SAN12:08 amSan Diego
$169
Frontier
Feb 19
SAN6:25 amSan Diego
10h 22m
1 stop
DSM6:47 pmDes Moines
Feb 23
DSM7:17 pmDes Moines
6h 51m
1 stop
SAN12:08 amSan Diego
$180

Southwest flights from San Diego to Des Moines

Our best Southwest deals on San Diego to Des Moines flight tickets
Southwest
May 7
SAN10:45 amSan Diego
5h 50m
1 stop
DSM6:35 pmDes Moines
May 20
DSM6:55 amDes Moines
7h 15m
2 stops
SAN12:10 pmSan Diego
$369
Southwest
Apr 18
SAN8:40 amSan Diego
7h 20m
2 stops
DSM6:00 pmDes Moines
Apr 25
DSM2:10 pmDes Moines
8h 00m
1 stop
SAN8:10 pmSan Diego
$382
Southwest
Apr 8
SAN12:30 pmSan Diego
6h 45m
2 stops
DSM9:15 pmDes Moines
Apr 13
DSM6:50 amDes Moines
7h 20m
2 stops
SAN12:10 pmSan Diego
$400

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 14, 2026.
Use the filters below to find and compare flights from San Diego to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Thu 2/12

6:25 am-6:47 pm

1 stop10h 22m

Des Moines

Fri 2/13

7:17 pm-12:08 am

1 stop6h 51m

$166

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Thu 2/12

6:25 am-6:47 pm

1 stop10h 22m

Des Moines

Fri 2/13

7:17 pm-12:08 am

1 stop6h 51m

$169

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Thu 2/19

6:25 am-6:47 pm

1 stop10h 22m

Des Moines

Mon 2/23

7:17 pm-12:08 am

1 stop6h 51m

$180

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Thu 2/12

6:25 am-6:47 pm

1 stop10h 22m

Des Moines

Fri 2/13

7:17 pm-7:53 pm

2 stops26h 36m

$198

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Wed 4/8

12:00 pm-8:13 pm

2 stops30h 13m

Des Moines

Mon 4/13

7:58 pm-12:01 am

1 stop6h 03m

$228

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Thu 2/19

6:25 am-6:47 pm

1 stop10h 22m

Des Moines

Sun 2/22

7:45 pm-12:08 am

1 stop6h 23m

$235

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Sat 2/14

8:00 am-6:32 pm

2 stops32h 32m

Des Moines

Mon 2/16

7:17 pm-12:08 am

1 stop6h 51m

$250

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Sat 2/14

12:23 pm-6:32 pm

1 stop28h 09m

Des Moines

Mon 2/16

7:17 pm-12:08 am

1 stop6h 51m

$259

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Sun 4/5

9:56 pm-6:46 pm

2 stops18h 50m

Des Moines

Sun 4/12

11:00 am-4:15 pm

1 stop31h 15m

$298

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Sun 4/5

9:56 pm-8:55 pm

1 stop20h 59m

Des Moines

Sun 4/12

11:00 am-4:15 pm

1 stop31h 15m

$309

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from San Diego to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in November, then July is your next best option. Flight prices from San Diego to Des Moines during July average around $328.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from San Diego to Des Moines is on a Sunday. Travelers who choose to depart for Des Moines on a Sunday will often find tickets for as low as $140. Flights from San Diego to Des Moines on a Monday will generally be more expensive and average around $171. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest San Diego to Des Moines flight route?

Fly from San Diego to Des Moines for the best San Diego - Des Moines flight prices

How far in advance should I book a flight to Des Moines?

You are more likely to see cheaper flights to Des Moines from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to Des Moines for around $379 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Des Moines from San Diego for as low as $164 on momondo.

What cabin class options are available on San Diego to Des Moines flights?

There is only 1 cabin class available to choose from on San Diego to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on San Diego to Des Moines flights?

No. A direct flight is the cheapest option for a flight between San Diego to Des Moines.

How have San Diego to Des Moines flight prices changed over time?

As of January 2026, prices for San Diego to Des Moines flights are approximately 10% cheaper when compared to flights at the same time last year.

When to book flights from San Diego to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to Des Moines (SAN to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Des Moines

Fastest flight time

5h 50m

Direct flights

None
The fastest flight from San Diego to Des Moines takes 5h 50m
There are no direct flights from San Diego to Des Moines. There are no popular flight routes from San Diego to Des Moines.
Search flight deals

  • How far is San Diego to Des Moines by plane?

    San Diego and Des Moines are 1426.2 mi apart from one another. Typically, this will take 5h 50m by plane in normal conditions.

  • When did momondo last update prices for flights from San Diego Airport to Des Moines Airport?

    Prices for flights from San Diego Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from San Diego Airport to Des Moines Airport?

  • How old do you have to be to fly from San Diego Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Diego Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from San Diego to Des Moines?

  • What is the most popular airline from San Diego to Des Moines?

Best airlines flying from San Diego to Des Moines

Compare and see reviews for airlines that fly from San Diego to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $75Free CancellationRating
7.2
702 reviews
Search Allegiant Air flights
DeltaPriceFrom $148Free CancellationRating
7.9
8,045 reviews
Search Delta flights
FrontierPriceFrom $162Free CancellationRating
5.7
3,056 reviews
Search Frontier flights
SouthwestPriceFrom $286Free CancellationRating
8.0
4,258 reviews
Search Southwest flights
United AirlinesPriceFrom $286Free CancellationRating
7.4
9,162 reviews
Search United Airlines flights
American AirlinesPriceFrom $286Free CancellationRating
7.2
11,125 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Urbandale
Clive
Pella
Newton
Johnston
Osceola
Boone
Norwalk
Oskaloosa
Grinnell
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from San Diego to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from San Diego to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from San Diego on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Diego to Des Moines?

momondo helps you find the best flight between San Diego and Des Moines by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from San Diego to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from San Diego are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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