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Cheap flights from San Diego to Des Moines from $124

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from San Diego to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:56 pm - 4:05 pmSAN  San Diego-DSM Des Moines
18h 09m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
8:23 pm - 12:24 pmDSM  Des Moines-SAN San Diego
18h 01m1 stop Las Vegas Harry Reid Intl
$278Multiple Airlines
Thu, Dec 24 - Tue, Dec 29
Multiple Airlines Logo
9:58 am - 10:50 amSAN  San Diego-DSM Des Moines
22h 52m1 stop Phoenix Sky Harbor Intl
Multiple Airlines Logo
8:26 pm - 11:58 pmDSM  Des Moines-SAN San Diego
29h 32m1 stop Denver Intl
$287Multiple Airlines
Wed, Dec 9 - Thu, Jan 14
American Airlines Logo
10:33 pm - 9:06 amSAN  San Diego-DSM Des Moines
8h 33m1 stop Chicago O'Hare Intl
American Airlines Logo
5:00 am - 8:40 amDSM  Des Moines-SAN San Diego
5h 40m1 stop Phoenix Sky Harbor Intl
$355American Airlines
Mon, Dec 21 - Thu, Dec 31
American Airlines Logo
6:15 am - 2:35 pmSAN  San Diego-DSM Des Moines
6h 20m1 stop Dallas/Fort Worth
American Airlines Logo
2:28 pm - 6:25 pmDSM  Des Moines-SAN San Diego
5h 57m1 stop Phoenix Sky Harbor Intl
$355American Airlines
Thu, Nov 26 - Tue, Dec 1
United Airlines Logo
8:40 am - 7:19 pmSAN  San Diego-DSM Des Moines
8h 39m2 stops Denver Intl Chicago O'Hare Intl
United Airlines Logo
1:35 pm - 5:16 pmDSM  Des Moines-SAN San Diego
5h 41m1 stop Denver Intl
$360United Airlines
Tue, Dec 8 - Wed, Jan 13
United Airlines Logo
8:50 am - 4:14 pmSAN  San Diego-DSM Des Moines
5h 24m1 stop Denver Intl
United Airlines Logo
6:00 am - 9:17 amDSM  Des Moines-SAN San Diego
5h 17m1 stop Denver Intl
$391United Airlines
Sat, May 1 - Wed, May 19
Southwest Logo
6:55 am - 5:00 pmSAN  San Diego-DSM Des Moines
8h 05m2 stops Las Vegas Harry Reid Intl Phoenix Sky Harbor Intl
Southwest Logo
10:20 am - 4:35 pmDSM  Des Moines-SAN San Diego
8h 15m2 stops Las Vegas Harry Reid Intl Phoenix Sky Harbor Intl
$421Southwest
Sat, May 1 - Wed, May 19
Southwest Logo
10:55 am - 8:50 pmSAN  San Diego-DSM Des Moines
7h 55m2 stops Phoenix Sky Harbor Intl Denver Intl
Southwest Logo
6:55 am - 1:05 pmDSM  Des Moines-SAN San Diego
8h 10m2 stops Denver Intl Oakland
$427Southwest
Tue, Dec 8 - Wed, Jan 13
Frontier Logo
4:16 pm - 7:31 pmSAN  San Diego-DSM Des Moines
25h 15m1 stop Denver Intl
Frontier Logo
8:26 pm - 11:58 pmDSM  Des Moines-SAN San Diego
5h 32m1 stop Denver Intl
$532Frontier
Wed, Dec 23 - Sun, Dec 27
Frontier Logo
4:16 pm - 7:31 pmSAN  San Diego-DSM Des Moines
25h 15m1 stop Denver Intl
Frontier Logo
8:26 pm - 11:58 pmDSM  Des Moines-SAN San Diego
5h 32m1 stop Denver Intl
$532Frontier
Wed, Dec 23 - Sun, Dec 27

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United Airlines flights from San Diego to Des Moines

Our best United Airlines deals on San Diego to Des Moines flight tickets
United Airlines
Dec 8
SAN8:40 amSan Diego
8h 39m
2 stops
DSM7:19 pmDes Moines
Jan 13
DSM1:35 pmDes Moines
5h 41m
1 stop
SAN5:16 pmSan Diego
$360
United Airlines
Nov 16
SAN6:45 amSan Diego
7h 22m
1 stop
DSM4:07 pmDes Moines
Nov 20
DSM5:30 amDes Moines
5h 40m
1 stop
SAN9:10 amSan Diego
$391
United Airlines
Nov 16
SAN2:30 pmSan Diego
7h 12m
2 stops
DSM11:42 pmDes Moines
Nov 20
DSM5:30 amDes Moines
5h 40m
1 stop
SAN9:10 amSan Diego
$396

Southwest flights from San Diego to Des Moines

Our best Southwest deals on San Diego to Des Moines flight tickets
Southwest
Dec 8
SAN10:55 amSan Diego
7h 55m
2 stops
DSM8:50 pmDes Moines
Jan 13
DSM6:55 amDes Moines
8h 10m
2 stops
SAN1:05 pmSan Diego
$427
Southwest
Dec 9
SAN10:30 amSan Diego
8h 20m
2 stops
DSM8:50 pmDes Moines
Jan 14
DSM10:50 amDes Moines
8h 15m
2 stops
SAN5:05 pmSan Diego
$492
Southwest
Nov 15
SAN11:35 amSan Diego
8h 30m
2 stops
DSM10:05 pmDes Moines
Nov 18
DSM7:00 amDes Moines
8h 50m
2 stops
SAN1:50 pmSan Diego
$563

momondo Fare Finder

 
Use the filters below to find and compare flights from San Diego to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San DiegoDes Moines

SAN San Diego - DSM Des Moines

SANDSM

San Diego

Thu 12/24

7:56 pm-4:05 pm

1 stop18h 09m

Des Moines

Tue 12/29

8:23 pm-12:24 pm

1 stop18h 01m

$278

San DiegoDes Moines

SAN San Diego - DSM Des Moines

SANDSM

San Diego

Wed 12/9

9:58 am-10:50 am

1 stop22h 52m

Des Moines

Thu 1/14

8:26 pm-11:58 pm

1 stop29h 32m

$287

San DiegoDes Moines

SAN San Diego - DSM Des Moines

SANDSM

San Diego

Mon 12/21

10:33 pm-9:06 am

1 stop8h 33m

Des Moines

Thu 12/31

5:00 am-8:40 am

1 stop5h 40m

$355

San DiegoDes Moines

SAN San Diego - DSM Des Moines

SANDSM

San Diego

Thu 11/26

6:15 am-2:35 pm

1 stop6h 20m

Des Moines

Tue 12/1

2:28 pm-6:25 pm

1 stop5h 57m

$355

San DiegoDes Moines

SAN San Diego - DSM Des Moines

SANDSM

San Diego

Tue 12/8

8:40 am-7:19 pm

2 stops8h 39m

Des Moines

Wed 1/13

1:35 pm-5:16 pm

1 stop5h 41m

$360
Quickest round-trip

San DiegoDes Moines

SAN San Diego - DSM Des Moines

SANDSM

San Diego

Sat 5/1

8:50 am-4:14 pm

1 stop5h 24m

Des Moines

Wed 5/19

6:00 am-9:17 am

1 stop5h 17m

$391

San DiegoDes Moines

SAN San Diego - DSM Des Moines

SANDSM

San Diego

Sat 5/1

6:55 am-5:00 pm

2 stops8h 05m

Des Moines

Wed 5/19

10:20 am-4:35 pm

2 stops8h 15m

$421

San DiegoDes Moines

SAN San Diego - DSM Des Moines

SANDSM

San Diego

Tue 12/8

10:55 am-8:50 pm

2 stops7h 55m

Des Moines

Wed 1/13

6:55 am-1:05 pm

2 stops8h 10m

$427

San DiegoDes Moines

SAN San Diego - DSM Des Moines

SANDSM

San Diego

Wed 12/23

4:16 pm-7:31 pm

1 stop25h 15m

Des Moines

Sun 12/27

8:26 pm-11:58 pm

1 stop5h 32m

$532

San DiegoDes Moines

SAN San Diego - DSM Des Moines

SANDSM

San Diego

Wed 12/23

4:16 pm-7:31 pm

1 stop25h 15m

Des Moines

Sun 12/27

8:26 pm-11:58 pm

1 stop5h 32m

$532

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from San Diego to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Diego and Des Moines?

Prices are currently low for flights on this route.

Typical prices usually range from $396 to $572.
The lowest price recently found on this route was $278.

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in September, then February is your next best option. Flight prices from San Diego to Des Moines during February average around $362.

How have San Diego to Des Moines flight prices changed over time?

As of November 2026, prices for San Diego to Des Moines flights are approximately 95% more expensive when compared to flights at the same time last year.

When to book flights from San Diego to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to Des Moines (SAN to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Des Moines

Best Price Found

$124

Fastest flight time

5h 24m

Direct flights

None
The best one-way flight to Des Moines from San Diego in the past 72 hours is $124. The best round-trip flight deal from San Diego to Des Moines found on momondo in the last 72 hours is $278.
The fastest flight from San Diego to Des Moines takes 5h 24m
There are no direct flights from San Diego to Des Moines. There are no popular flight routes from San Diego to Des Moines.
Search flight deals

Frequently asked questions about flying from San Diego to Des Moines

  • How far is San Diego to Des Moines by plane?

    San Diego and Des Moines are 1426.2 mi apart from one another. Typically, this will take 5h 24m by plane in normal conditions.

  • When did momondo last update prices for flights from San Diego Airport to Des Moines Airport?

    Prices for flights from San Diego Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from San Diego Airport to Des Moines Airport?

  • How old do you have to be to fly from San Diego Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Diego Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from San Diego to Des Moines?

Best airlines flying from San Diego to Des Moines

Compare and see reviews for airlines that fly from San Diego to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $95Free CancellationRating
5.5
2,512 reviews
Search Frontier flights
American AirlinesPriceFrom $208Free CancellationRating
7.0
12,233 reviews
Search American Airlines flights
United AirlinesPriceFrom $296Free CancellationRating
7.3
10,461 reviews
Search United Airlines flights
SouthwestPriceFrom $336Free CancellationRating
8.0
4,215 reviews
Search Southwest flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Clive
Altoona
Pella
Urbandale
Osceola
Boone
Johnston
Newton
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from San Diego to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from San Diego to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from San Diego on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Diego to Des Moines?

momondo helps you find the best flight between San Diego and Des Moines by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from San Diego to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from San Diego are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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