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Cheap flights from San Diego to Des Moines from $108

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to Des Moines departing on 10/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from San Diego to Des Moines

Cheap round-trip flights

Multiple Airlines Logo
6:15 am - 10:40 pmSAN-DSM
14h 25m1 stop
Multiple Airlines Logo
2:25 pm - 11:53 pmDSM-SAN
11h 28m1 stop
$194Multiple Airlines
Find Deal
Thu, Oct 2 - Mon, Oct 6
Multiple Airlines Logo
1:35 pm - 2:27 pmSAN-DSM
22h 52m1 stop
Multiple Airlines Logo
2:25 pm - 11:53 pmDSM-SAN
11h 28m1 stop
$199Multiple Airlines
Find Deal
Tue, Sep 30 - Mon, Oct 6
Frontier Logo
6:41 am - 1:52 pmSAN-DSM
5h 11m1 stop
Frontier Logo
2:37 pm - 11:50 pmDSM-SAN
11h 13m1 stop
$201Frontier
Find Deal
Thu, Oct 16 - Wed, Oct 22
Multiple Airlines Logo
8:25 am - 10:40 pmSAN-DSM
12h 15m1 stop
Multiple Airlines Logo
7:30 am - 9:20 pmDSM-SAN
15h 50m1 stop
$202Multiple Airlines
Find Deal
Thu, Oct 2 - Wed, Oct 8
Frontier Logo
6:41 am - 1:52 pmSAN-DSM
5h 11m1 stop
Frontier Logo
2:37 pm - 11:50 pmDSM-SAN
11h 13m1 stop
$261Frontier
Find Deal
Wed, Oct 15 - Sun, Oct 19
Southwest Logo
7:10 am - 3:35 pmSAN-DSM
6h 25m1 stop
Southwest Logo
5:45 am - 11:50 amDSM-SAN
8h 05m1 stop
$268Southwest
Find Deal
Wed, Nov 19 - Mon, Nov 24
United Airlines Logo
11:02 am - 8:45 pmSAN-DSM
7h 43m2 stops
United Airlines Logo
2:52 pm - 8:05 pmDSM-SAN
7h 13m1 stop
$273United Airlines
Find Deal
Wed, Nov 19 - Mon, Nov 24
American Airlines Logo
12:43 pm - 10:59 pmSAN-DSM
8h 16m1 stop
American Airlines Logo
5:00 am - 8:47 amDSM-SAN
5h 47m1 stop
$297American Airlines
Find Deal
Wed, Dec 10 - Wed, Dec 17
American Airlines Logo
3:14 pm - 11:16 pmSAN-DSM
6h 02m1 stop
American Airlines Logo
3:48 pm - 10:44 pmDSM-SAN
8h 56m1 stop
$312American Airlines
Find Deal
Wed, Oct 8 - Fri, Oct 10
United Airlines Logo
11:02 am - 8:48 pmSAN-DSM
7h 46m2 stops
United Airlines Logo
9:00 am - 1:04 pmDSM-SAN
6h 04m1 stop
$382United Airlines
Find Deal
Wed, Dec 10 - Wed, Dec 17

Frontier flights from San Diego to Des Moines

Our best Frontier deals on San Diego to Des Moines flight tickets
Frontier
Oct 16
SAN6:41 amSan Diego
5h 11m
1 stop
DSM1:52 pmDes Moines
Oct 22
DSM2:37 pmDes Moines
11h 13m
1 stop
SAN11:50 pmSan Diego
$201
Find similar
Frontier
Oct 15
SAN6:41 amSan Diego
5h 11m
1 stop
DSM1:52 pmDes Moines
Oct 19
DSM2:37 pmDes Moines
11h 13m
1 stop
SAN11:50 pmSan Diego
$261
Find similar
Frontier
Oct 16
SAN7:23 pmSan Diego
16h 29m
2 stops
DSM1:52 pmDes Moines
Oct 22
DSM2:37 pmDes Moines
11h 13m
1 stop
SAN11:50 pmSan Diego
$333
Find similar

American Airlines flights from San Diego to Des Moines

Our best American Airlines deals on San Diego to Des Moines flight tickets
American Airlines
Dec 10
SAN12:43 pmSan Diego
8h 16m
1 stop
DSM10:59 pmDes Moines
Dec 17
DSM5:00 amDes Moines
5h 47m
1 stop
SAN8:47 amSan Diego
$297
Find similar
American Airlines
Oct 8
SAN3:14 pmSan Diego
6h 02m
1 stop
DSM11:16 pmDes Moines
Oct 10
DSM3:48 pmDes Moines
8h 56m
1 stop
SAN10:44 pmSan Diego
$312
Find similar
American Airlines
Oct 24
SAN3:14 pmSan Diego
6h 02m
1 stop
DSM11:16 pmDes Moines
Nov 1
DSM3:48 pmDes Moines
6h 25m
1 stop
SAN8:13 pmSan Diego
$341
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from San Diego to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Thu 10/2

6:15 am-10:40 pm

1 stop14h 25m

Des Moines

Mon 10/6

2:25 pm-11:53 pm

1 stop11h 28m

$194

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Tue 9/30

1:35 pm-2:27 pm

1 stop22h 52m

Des Moines

Mon 10/6

2:25 pm-11:53 pm

1 stop11h 28m

$199

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Thu 10/16

6:41 am-1:52 pm

1 stop5h 11m

Des Moines

Wed 10/22

2:37 pm-11:50 pm

1 stop11h 13m

$201

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Thu 10/2

8:25 am-10:40 pm

1 stop12h 15m

Des Moines

Wed 10/8

7:30 am-9:20 pm

1 stop15h 50m

$202

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Wed 10/15

6:41 am-1:52 pm

1 stop5h 11m

Des Moines

Sun 10/19

2:37 pm-11:50 pm

1 stop11h 13m

$261

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Wed 11/19

7:10 am-3:35 pm

1 stop6h 25m

Des Moines

Mon 11/24

5:45 am-11:50 am

1 stop8h 05m

$268

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Wed 11/19

11:02 am-8:45 pm

2 stops7h 43m

Des Moines

Mon 11/24

2:52 pm-8:05 pm

1 stop7h 13m

$273

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Wed 12/10

12:43 pm-10:59 pm

1 stop8h 16m

Des Moines

Wed 12/17

5:00 am-8:47 am

1 stop5h 47m

$297

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Wed 10/8

3:14 pm-11:16 pm

1 stop6h 02m

Des Moines

Fri 10/10

3:48 pm-10:44 pm

1 stop8h 56m

$312

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Wed 12/10

11:02 am-8:48 pm

2 stops7h 46m

Des Moines

Wed 12/17

9:00 am-1:04 pm

1 stop6h 04m

$382

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from San Diego to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in May, then July is your next best option. Flight prices from San Diego to Des Moines during July average around $329.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from San Diego to Des Moines is on a Sunday. Travelers who choose to depart for Des Moines on a Sunday will often find tickets for as low as $140. Flights from San Diego to Des Moines on a Wednesday will generally be more expensive and average around $436. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the afternoon. momondo users have found flights departing from San Diego to Des Moines in the afternoon for as low as $171. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the evening because they tend to be around $562. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest San Diego to Des Moines flight route?

Fly from San Diego to Des Moines for the best San Diego - Des Moines flight prices

How far in advance should I book a flight to Des Moines?

You are more likely to see cheaper flights to Des Moines from San Diego when booking weeks ahead of your departure date. In general, you can expect to find flights to Des Moines for around $407 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Des Moines from San Diego for as low as $198 on momondo.

What cabin class options are available on San Diego to Des Moines flights?

There is only 1 cabin class available to choose from on San Diego to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on San Diego to Des Moines flights?

You could potentially save up to 42% on your flight if you consider stops on a San Diego to Des Moines flight.

How have San Diego to Des Moines flight prices changed over time?

As of September 2025, prices for San Diego to Des Moines flights are approximately 36% more expensive when compared to flights at the same time last year.

When to book flights from San Diego to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to Des Moines (SAN to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Des Moines

Direct flights

None
There are no direct flights from San Diego to Des Moines. There are no popular flight routes from San Diego to Des Moines.
Search flight deals

  • How far is San Diego to Des Moines by plane?

    San Diego and Des Moines are 1426.2 mi apart from one another. Typically, this will take 5h 11m by plane in normal conditions.

  • When did momondo last update prices for flights from San Diego Airport to Des Moines Airport?

    Prices for flights from San Diego Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from San Diego Airport to Des Moines Airport?

  • How old do you have to be to fly from San Diego Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Diego Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from San Diego to Des Moines?

  • What is the most popular airline from San Diego to Des Moines?

Best airlines flying from San Diego to Des Moines

Compare and see reviews for airlines that fly from San Diego to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $75Free CancellationRating
7.2
699 reviews
Search Allegiant Air flights
FrontierPriceFrom $134Free CancellationRating
5.8
3,173 reviews
Search Frontier flights
DeltaPriceFrom $237Free CancellationRating
7.9
7,961 reviews
Search Delta flights
United AirlinesPriceFrom $286Free CancellationRating
7.4
8,926 reviews
Search United Airlines flights
American AirlinesPriceFrom $286Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
SouthwestPriceFrom $306Free CancellationRating
8.0
4,242 reviews
Search Southwest flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Newton
Osceola
Johnston
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from San Diego to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from San Diego to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from San Diego on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Diego to Des Moines?

momondo helps you find the best flight between San Diego and Des Moines by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from San Diego to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from San Diego are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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