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Cheap flights from San Diego to Des Moines from $111

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Diego to Des Moines departing on 9/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from San Diego to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
4:54 pm - 10:44 am
SAN
-
DSM
15h 50m
1 stop
Frontier Logo
11:29 am - 11:51 pm
DSM
-
SAN
14h 22m
1 stop
$205Frontier
Sat, Sep 12 - Sun, Sep 27
Multiple Airlines Logo
9:03 pm - 8:41 pm
SAN
-
DSM
21h 38m
1 stop
Multiple Airlines Logo
9:31 pm - 4:59 pm
DSM
-
SAN
21h 28m
1 stop
$211Multiple Airlines
Thu, Sep 10 - Mon, Sep 14
Multiple Airlines Logo
4:54 pm - 7:33 pm
SAN
-
DSM
24h 39m
1 stop
Multiple Airlines Logo
9:31 pm - 4:59 pm
DSM
-
SAN
21h 28m
1 stop
$214Multiple Airlines
Thu, Sep 10 - Mon, Sep 14
Frontier Logo
3:45 pm - 1:34 pm
SAN
-
DSM
19h 49m
1 stop
Frontier Logo
11:29 am - 11:51 pm
DSM
-
SAN
14h 22m
1 stop
$256Frontier
Thu, Sep 3 - Thu, Sep 10
American Airlines Logo
8:00 am - 6:55 pm
SAN
-
DSM
8h 55m
1 stop
American Airlines Logo
5:30 am - 8:50 am
DSM
-
SAN
5h 20m
1 stop
$355American Airlines
Thu, Aug 27 - Thu, Sep 3
American Airlines Logo
8:00 am - 5:52 pm
SAN
-
DSM
7h 52m
1 stop
American Airlines Logo
5:56 pm - 11:25 pm
DSM
-
SAN
7h 29m
1 stop
$355American Airlines
Tue, Sep 8 - Mon, Sep 14
Southwest Logo
10:30 am - 9:15 pm
SAN
-
DSM
8h 45m
2 stops
Southwest Logo
12:05 pm - 4:40 pm
DSM
-
SAN
6h 35m
1 stop
$360Southwest
Thu, Aug 27 - Thu, Sep 3
United Airlines Logo
6:18 am - 5:28 pm
SAN
-
DSM
9h 10m
1 stop
United Airlines Logo
1:35 pm - 5:00 pm
DSM
-
SAN
5h 25m
1 stop
$365United Airlines
Sat, Aug 29 - Sat, Sep 5
United Airlines Logo
6:40 am - 5:28 pm
SAN
-
DSM
8h 48m
1 stop
United Airlines Logo
1:35 pm - 5:00 pm
DSM
-
SAN
5h 25m
1 stop
$365United Airlines
Wed, Sep 2 - Sun, Sep 6
Southwest Logo
11:10 am - 9:05 pm
SAN
-
DSM
7h 55m
2 stops
Southwest Logo
4:50 pm - 10:55 pm
DSM
-
SAN
8h 05m
2 stops
$395Southwest
Tue, Sep 22 - Sat, Sep 26

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Frontier flights from San Diego to Des Moines

Our best Frontier deals on San Diego to Des Moines flight tickets
Frontier
Sep 12
SAN4:54 pmSan Diego
15h 50m
1 stop
DSM10:44 amDes Moines
Sep 27
DSM11:29 amDes Moines
14h 22m
1 stop
SAN11:51 pmSan Diego
$205
Frontier
Sep 3
SAN3:45 pmSan Diego
19h 49m
1 stop
DSM1:34 pmDes Moines
Sep 10
DSM11:29 amDes Moines
14h 22m
1 stop
SAN11:51 pmSan Diego
$256
Frontier
Sep 25
SAN6:25 amSan Diego
11h 08m
1 stop
DSM7:33 pmDes Moines
Oct 1
DSM11:29 amDes Moines
14h 22m
1 stop
SAN11:51 pmSan Diego
$259

Delta flights from San Diego to Des Moines

Our best Delta deals on San Diego to Des Moines flight tickets
Delta
Aug 6
SAN7:02 pmSan Diego
13h 16m
2 stops
DSM10:18 amDes Moines
Aug 13
DSM6:55 amDes Moines
13h 10m
2 stops
SAN6:05 pmSan Diego
$1,444
Delta
Aug 6
SAN7:02 pmSan Diego
13h 16m
2 stops
DSM10:18 amDes Moines
Aug 13
DSM6:55 amDes Moines
10h 21m
2 stops
SAN3:16 pmSan Diego
$1,479

momondo Fare Finder

 
Customize your flight search to find flights from San Diego to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 4, 2026.
Use the filters below to find and compare flights from San Diego to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Sat 9/12

4:54 pm-10:44 am

1 stop15h 50m

Des Moines

Sun 9/27

11:29 am-11:51 pm

1 stop14h 22m

$205

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Thu 9/10

9:03 pm-8:41 pm

1 stop21h 38m

Des Moines

Mon 9/14

9:31 pm-4:59 pm

1 stop21h 28m

$211

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Thu 9/10

4:54 pm-7:33 pm

1 stop24h 39m

Des Moines

Mon 9/14

9:31 pm-4:59 pm

1 stop21h 28m

$214

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Thu 9/3

3:45 pm-1:34 pm

1 stop19h 49m

Des Moines

Thu 9/10

11:29 am-11:51 pm

1 stop14h 22m

$256

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Thu 8/27

8:00 am-6:55 pm

1 stop8h 55m

Des Moines

Thu 9/3

5:30 am-8:50 am

1 stop5h 20m

$355

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Tue 9/8

8:00 am-5:52 pm

1 stop7h 52m

Des Moines

Mon 9/14

5:56 pm-11:25 pm

1 stop7h 29m

$355

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Thu 8/27

10:30 am-9:15 pm

2 stops8h 45m

Des Moines

Thu 9/3

12:05 pm-4:40 pm

1 stop6h 35m

$360

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Sat 8/29

6:18 am-5:28 pm

1 stop9h 10m

Des Moines

Sat 9/5

1:35 pm-5:00 pm

1 stop5h 25m

$365
Quickest round-trip

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Wed 9/2

6:40 am-5:28 pm

1 stop8h 48m

Des Moines

Sun 9/6

1:35 pm-5:00 pm

1 stop5h 25m

$365

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Tue 9/22

11:10 am-9:05 pm

2 stops7h 55m

Des Moines

Sat 9/26

4:50 pm-10:55 pm

2 stops8h 05m

$395

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from San Diego to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Diego and Des Moines?

Prices are currently low for flights on this route.

Typical prices usually range from $286 to $520.
The lowest price recently found on this route was $205.

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in November, then October is your next best option. Flight prices from San Diego to Des Moines during October average around $359.

What is the cheapest San Diego to Des Moines flight route?

Fly from San Diego to Des Moines for the best San Diego - Des Moines flight prices

What cabin class options are available on San Diego to Des Moines flights?

There is only 1 cabin class available to choose from on San Diego to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on San Diego to Des Moines flights?

You could potentially save up to 2% on your flight if you consider stops on a San Diego to Des Moines flight.

How have San Diego to Des Moines flight prices changed over time?

As of August 2026, prices for San Diego to Des Moines flights are approximately 18% more expensive when compared to flights at the same time last year.

When to book flights from San Diego to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from San Diego to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Diego to Des Moines (SAN to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Diego to Des Moines

Fastest flight time

5h 41m

Direct flights

None
The fastest flight from San Diego to Des Moines takes 5h 41m
There are no direct flights from San Diego to Des Moines. There are no popular flight routes from San Diego to Des Moines.
Search flight deals

Frequently asked questions about flying from San Diego to Des Moines

  • How far is San Diego to Des Moines by plane?

    San Diego and Des Moines are 1426.2 mi apart from one another. Typically, this will take 5h 41m by plane in normal conditions.

  • When did momondo last update prices for flights from San Diego Airport to Des Moines Airport?

    Prices for flights from San Diego Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from San Diego Airport to Des Moines Airport?

  • How old do you have to be to fly from San Diego Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from San Diego Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from San Diego to Des Moines?

  • What is the most popular airline from San Diego to Des Moines?

Best airlines flying from San Diego to Des Moines

Compare and see reviews for airlines that fly from San Diego to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $148Free CancellationRating
7.8
8,483 reviews
Search Delta flights
FrontierPriceFrom $158Free CancellationRating
5.6
2,738 reviews
Search Frontier flights
American AirlinesPriceFrom $208Free CancellationRating
7.1
11,846 reviews
Search American Airlines flights
United AirlinesPriceFrom $286Free CancellationRating
7.4
10,059 reviews
Search United Airlines flights
SouthwestPriceFrom $310Free CancellationRating
8.0
4,222 reviews
Search Southwest flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Clive
Altoona
Pella
Urbandale
Newton
Osceola
Johnston
Boone
Oskaloosa
Norwalk
Grinnell
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from San Diego to Des Moines?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from San Diego to Des Moines. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from San Diego to Des Moines with flexible booking policies on momondo?

Yes. All flights to Des Moines from San Diego on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from San Diego to Des Moines?

momondo helps you find the best flight between San Diego and Des Moines by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from San Diego to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from San Diego are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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