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Cheap flights from San Antonio to Knoxville from $101

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Antonio to Knoxville departing on 1/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from San Antonio to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:41 am - 3:56 pm
SAT
-
TYS
8h 15m1 stop
American Airlines Logo
4:41 pm - 10:58 pm
TYS
-
SAT
7h 17m1 stop
$237American Airlines
Thu, Feb 5 - Mon, Feb 9
Delta Logo
5:20 am - 11:08 am
SAT
-
TYS
4h 48m1 stop
Delta Logo
11:58 am - 5:22 pm
TYS
-
SAT
6h 24m1 stop
$253Delta
Thu, Feb 5 - Sun, Feb 8
Multiple Airlines Logo
10:35 am - 6:28 pm
SAT
-
TYS
6h 53m1 stop
Multiple Airlines Logo
1:39 pm - 5:03 pm
TYS
-
SAT
28h 24m2 stops
$259Multiple Airlines
Thu, Feb 5 - Sun, Feb 8
American Airlines Logo
8:30 am - 5:16 pm
SAT
-
TYS
7h 46m1 stop
American Airlines Logo
5:40 am - 9:33 am
TYS
-
SAT
4h 53m1 stop
$268American Airlines
Mon, Feb 16 - Mon, Feb 23
American Airlines Logo
4:40 pm - 10:47 pm
SAT
-
TYS
5h 07m1 stop
American Airlines Logo
4:41 pm - 9:52 pm
TYS
-
SAT
6h 11m1 stop
$269American Airlines
Fri, Feb 6 - Sun, Feb 8
Southwest Logo
6:00 am - 11:50 am
SAT
-
TYS
4h 50m1 stop
Southwest Logo
1:35 pm - 12:30 am
TYS
-
SAT
11h 55m1 stop
$279Southwest
Wed, Mar 11 - Sun, Mar 15
Southwest Logo
11:10 am - 8:05 pm
SAT
-
TYS
7h 55m2 stops
Southwest Logo
1:35 pm - 12:30 am
TYS
-
SAT
11h 55m1 stop
$284Southwest
Wed, Mar 11 - Sun, Mar 15
United Airlines Logo
4:04 pm - 11:44 pm
SAT
-
TYS
6h 40m1 stop
United Airlines Logo
6:45 am - 12:24 pm
TYS
-
SAT
6h 39m1 stop
$295United Airlines
Sat, Jan 24 - Sun, Jan 25
Multiple Airlines Logo
10:26 am - 1:04 pm
SAT
-
TYS
25h 38m1 stop
Multiple Airlines Logo
9:36 pm - 9:30 am
TYS
-
SAT
12h 54m1 stop
$296Multiple Airlines
Fri, Feb 13 - Mon, Feb 16
United Airlines Logo
11:43 am - 8:52 pm
SAT
-
TYS
8h 09m2 stops
United Airlines Logo
6:59 am - 10:47 am
TYS
-
SAT
4h 48m1 stop
$304United Airlines
Sat, Jan 24 - Sun, Jan 25

United Airlines flights from San Antonio to Knoxville

Our best United Airlines deals on San Antonio to Knoxville flight tickets
United Airlines
Jan 17
SAT2:05 pmSan Antonio
5h 47m
1 stop
TYS8:52 pmKnoxville McGhee Tyson
Jan 25
TYS6:59 amKnoxville McGhee Tyson
4h 48m
1 stop
SAT10:47 amSan Antonio
$258
United Airlines
Jan 17
SAT2:05 pmSan Antonio
5h 47m
1 stop
TYS8:52 pmKnoxville McGhee Tyson
Jan 25
TYS6:45 amKnoxville McGhee Tyson
9h 46m
2 stops
SAT3:31 pmSan Antonio
$263
United Airlines
Jan 24
SAT4:04 pmSan Antonio
6h 40m
1 stop
TYS11:44 pmKnoxville McGhee Tyson
Jan 25
TYS6:45 amKnoxville McGhee Tyson
6h 39m
1 stop
SAT12:24 pmSan Antonio
$295

American Airlines flights from San Antonio to Knoxville

Our best American Airlines deals on San Antonio to Knoxville flight tickets
American Airlines
Feb 5
SAT6:41 amSan Antonio
8h 15m
1 stop
TYS3:56 pmKnoxville McGhee Tyson
Feb 9
TYS4:41 pmKnoxville McGhee Tyson
7h 17m
1 stop
SAT10:58 pmSan Antonio
$237
American Airlines
Feb 16
SAT8:30 amSan Antonio
7h 46m
1 stop
TYS5:16 pmKnoxville McGhee Tyson
Feb 23
TYS5:40 amKnoxville McGhee Tyson
4h 53m
1 stop
SAT9:33 amSan Antonio
$268
American Airlines
Feb 6
SAT4:40 pmSan Antonio
5h 07m
1 stop
TYS10:47 pmKnoxville McGhee Tyson
Feb 8
TYS4:41 pmKnoxville McGhee Tyson
6h 11m
1 stop
SAT9:52 pmSan Antonio
$269

momondo Fare Finder

 
Customize your flight search to find flights from San Antonio to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 8, 2026.
Use the filters below to find and compare flights from San Antonio to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Thu 2/5

6:41 am-3:56 pm

1 stop8h 15m

Knoxville McGhee Tyson

Mon 2/9

4:41 pm-10:58 pm

1 stop7h 17m

$237

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Thu 2/5

5:20 am-11:08 am

1 stop4h 48m

Knoxville McGhee Tyson

Sun 2/8

11:58 am-5:22 pm

1 stop6h 24m

$253

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Thu 2/5

10:35 am-6:28 pm

1 stop6h 53m

Knoxville McGhee Tyson

Sun 2/8

1:39 pm-5:03 pm

2 stops28h 24m

$259

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Mon 2/16

8:30 am-5:16 pm

1 stop7h 46m

Knoxville McGhee Tyson

Mon 2/23

5:40 am-9:33 am

1 stop4h 53m

$268

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Fri 2/6

4:40 pm-10:47 pm

1 stop5h 07m

Knoxville McGhee Tyson

Sun 2/8

4:41 pm-9:52 pm

1 stop6h 11m

$269

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Wed 3/11

6:00 am-11:50 am

1 stop4h 50m

Knoxville McGhee Tyson

Sun 3/15

1:35 pm-12:30 am

1 stop11h 55m

$279

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Wed 3/11

11:10 am-8:05 pm

2 stops7h 55m

Knoxville McGhee Tyson

Sun 3/15

1:35 pm-12:30 am

1 stop11h 55m

$284

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Sat 1/24

4:04 pm-11:44 pm

1 stop6h 40m

Knoxville McGhee Tyson

Sun 1/25

6:45 am-12:24 pm

1 stop6h 39m

$295

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Fri 2/13

10:26 am-1:04 pm

1 stop25h 38m

Knoxville McGhee Tyson

Mon 2/16

9:36 pm-9:30 am

1 stop12h 54m

$296

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Sat 1/24

11:43 am-8:52 pm

2 stops8h 09m

Knoxville McGhee Tyson

Sun 1/25

6:59 am-10:47 am

1 stop4h 48m

$304

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from San Antonio to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of October is, on average, the cheapest month to fly to Knoxville from San Antonio, with most prices found around $254. If you aren’t able to travel during the month of October, then book flights to Knoxville from San Antonio during January instead. Flights to Knoxville in January, while not as cheap as those in October, still average around $268.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from San Antonio when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $349 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from San Antonio for as low as $178 on momondo.

How have San Antonio to Knoxville flight prices changed over time?

As of January 2026, prices for San Antonio to Knoxville flights are approximately 36% more expensive when compared to flights at the same time last year.

When to book flights from San Antonio to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Antonio to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Antonio to Knoxville (SAT to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Antonio to Knoxville

Fastest flight time

4h 26m

Direct flights

None
The fastest flight from San Antonio to Knoxville takes 4h 26m
There are no direct flights from San Antonio to Knoxville. There are no popular flight routes from San Antonio to Knoxville.
Search flight deals

  • How far is San Antonio to Knoxville McGhee Tyson by plane?

    A flight from San Antonio to Knoxville McGhee Tyson will travel around 958.1 mi. 4h 26m is a normal flight duration for this route.

  • When did momondo last update prices for flights from San Antonio Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Antonio Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from San Antonio Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Antonio Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Antonio Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from San Antonio to Knoxville?

Best airlines flying from San Antonio to Knoxville

Compare and see reviews for airlines that fly from San Antonio to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $144Free CancellationRating
7.9
8,025 reviews
Search Delta flights
American AirlinesPriceFrom $216Free CancellationRating
7.2
11,095 reviews
Search American Airlines flights
United AirlinesPriceFrom $259Free CancellationRating
7.4
9,139 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Murphy
Crossville
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from San Antonio to Knoxville?

It is quick and easy to find San Antonio to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from San Antonio to Knoxville with flexible booking policies on momondo?

Flights from San Antonio to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Antonio to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from San Antonio. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from San Antonio to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Antonio to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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