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Cheap flights from San Antonio to Knoxville from $126

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Antonio to Knoxville departing on 9/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from San Antonio to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:43 pm - 11:18 pmSAT  San Antonio-TYS Knoxville McGhee Tyson
4h 35m1 stop Dallas/Fort Worth
American Airlines Logo
6:20 am - 12:25 pmTYS  Knoxville McGhee Tyson-SAT San Antonio
7h 05m1 stop Charlotte Douglas
$251American Airlines
Tue, Oct 20 - Tue, Oct 27
Delta Logo
7:50 am - 1:55 pmSAT  San Antonio-TYS Knoxville McGhee Tyson
5h 05m1 stop Atlanta Hartsfield-Jackson
Delta Logo
12:34 pm - 5:27 pmTYS  Knoxville McGhee Tyson-SAT San Antonio
5h 53m1 stop Atlanta Hartsfield-Jackson
$251Delta
Sat, Dec 12 - Mon, Dec 14
Delta Logo
5:00 pm - 10:22 pmSAT  San Antonio-TYS Knoxville McGhee Tyson
4h 22m1 stop Atlanta Hartsfield-Jackson
Delta Logo
12:34 pm - 5:27 pmTYS  Knoxville McGhee Tyson-SAT San Antonio
5h 53m1 stop Atlanta Hartsfield-Jackson
$251Delta
Sat, Dec 12 - Mon, Dec 14
Multiple Airlines Logo
12:38 pm - 8:09 pmSAT  San Antonio-TYS Knoxville McGhee Tyson
6h 31m1 stop Memphis
Multiple Airlines Logo
5:38 pm - 11:58 amTYS  Knoxville McGhee Tyson-SAT San Antonio
19h 20m1 stop Memphis
$262Multiple Airlines
Fri, Sep 25 - Sun, Sep 27
Multiple Airlines Logo
12:38 pm - 8:09 pmSAT  San Antonio-TYS Knoxville McGhee Tyson
6h 31m1 stop Memphis
Multiple Airlines Logo
5:38 pm - 11:58 amTYS  Knoxville McGhee Tyson-SAT San Antonio
19h 20m1 stop Memphis
$265Multiple Airlines
Fri, Sep 25 - Sun, Sep 27
Southwest Logo
5:35 am - 1:25 pmSAT  San Antonio-TYS Knoxville McGhee Tyson
6h 50m1 stop Dallas Love Field
Southwest Logo
1:00 pm - 10:05 pmTYS  Knoxville McGhee Tyson-SAT San Antonio
10h 05m1 stop Orlando
$292Southwest
Mon, Sep 14 - Fri, Sep 18
Southwest Logo
7:10 am - 1:25 pmSAT  San Antonio-TYS Knoxville McGhee Tyson
5h 15m1 stop Dallas Love Field
Southwest Logo
1:00 pm - 10:05 pmTYS  Knoxville McGhee Tyson-SAT San Antonio
10h 05m1 stop Orlando
$292Southwest
Fri, Sep 11 - Fri, Sep 18
American Airlines Logo
5:54 pm - 11:18 pmSAT  San Antonio-TYS Knoxville McGhee Tyson
4h 24m1 stop Dallas/Fort Worth
American Airlines Logo
11:49 am - 3:50 pmTYS  Knoxville McGhee Tyson-SAT San Antonio
5h 01m1 stop Dallas/Fort Worth
$303American Airlines
Sat, Aug 29 - Sat, Sep 5
United Airlines Logo
11:34 am - 8:53 pmSAT  San Antonio-TYS Knoxville McGhee Tyson
8h 19m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
United Airlines Logo
2:21 pm - 5:44 pmTYS  Knoxville McGhee Tyson-SAT San Antonio
4h 23m1 stop Houston George Bush Intcntl
$308United Airlines
Sat, Aug 29 - Sat, Sep 5
United Airlines Logo
5:30 pm - 12:23 amSAT  San Antonio-TYS Knoxville McGhee Tyson
5h 53m1 stop Chicago O'Hare Intl
United Airlines Logo
6:02 pm - 10:51 pmTYS  Knoxville McGhee Tyson-SAT San Antonio
5h 49m1 stop Chicago O'Hare Intl
$319United Airlines
Tue, Sep 15 - Mon, Sep 21

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Delta flights from San Antonio to Knoxville

Our best Delta deals on San Antonio to Knoxville flight tickets
Delta
Dec 12
SAT7:50 amSan Antonio
5h 05m
1 stop
TYS1:55 pmKnoxville McGhee Tyson
Dec 14
TYS12:34 pmKnoxville McGhee Tyson
5h 53m
1 stop
SAT5:27 pmSan Antonio
$251
Delta
Sep 22
SAT4:21 pmSan Antonio
6h 34m
1 stop
TYS11:55 pmKnoxville McGhee Tyson
Sep 25
TYS5:20 pmKnoxville McGhee Tyson
4h 54m
1 stop
SAT9:14 pmSan Antonio
$285
Delta
Oct 30
SAT5:30 amSan Antonio
7h 10m
1 stop
TYS1:40 pmKnoxville McGhee Tyson
Nov 2
TYS5:40 amKnoxville McGhee Tyson
5h 02m
1 stop
SAT9:42 amSan Antonio
$321

Southwest flights from San Antonio to Knoxville

Our best Southwest deals on San Antonio to Knoxville flight tickets
Southwest
Sep 11
SAT7:10 amSan Antonio
5h 15m
1 stop
TYS1:25 pmKnoxville McGhee Tyson
Sep 18
TYS1:00 pmKnoxville McGhee Tyson
10h 05m
1 stop
SAT10:05 pmSan Antonio
$292
Southwest
Sep 22
SAT9:25 amSan Antonio
8h 35m
2 stops
TYS7:00 pmKnoxville McGhee Tyson
Sep 25
TYS1:00 pmKnoxville McGhee Tyson
10h 05m
1 stop
SAT10:05 pmSan Antonio
$297
Southwest
Sep 22
SAT9:20 amSan Antonio
8h 40m
2 stops
TYS7:00 pmKnoxville McGhee Tyson
Sep 25
TYS2:05 pmKnoxville McGhee Tyson
8h 55m
2 stops
SAT10:00 pmSan Antonio
$305

momondo Fare Finder

 
Customize your flight search to find flights from San Antonio to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 11, 2026.
Use the filters below to find and compare flights from San Antonio to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San AntonioKnoxville

SAT San Antonio - TYS Knoxville McGhee Tyson

SATTYS

San Antonio

Tue 10/20

5:43 pm-11:18 pm

1 stop4h 35m

Knoxville McGhee Tyson

Tue 10/27

6:20 am-12:25 pm

1 stop7h 05m

$251

San AntonioKnoxville

SAT San Antonio - TYS Knoxville McGhee Tyson

SATTYS

San Antonio

Sat 12/12

7:50 am-1:55 pm

1 stop5h 05m

Knoxville McGhee Tyson

Mon 12/14

12:34 pm-5:27 pm

1 stop5h 53m

$251

San AntonioKnoxville

SAT San Antonio - TYS Knoxville McGhee Tyson

SATTYS

San Antonio

Sat 12/12

5:00 pm-10:22 pm

1 stop4h 22m

Knoxville McGhee Tyson

Mon 12/14

12:34 pm-5:27 pm

1 stop5h 53m

$251

San AntonioKnoxville

SAT San Antonio - TYS Knoxville McGhee Tyson

SATTYS

San Antonio

Fri 9/25

12:38 pm-8:09 pm

1 stop6h 31m

Knoxville McGhee Tyson

Sun 9/27

5:38 pm-11:58 am

1 stop19h 20m

$262

San AntonioKnoxville

SAT San Antonio - TYS Knoxville McGhee Tyson

SATTYS

San Antonio

Fri 9/25

12:38 pm-8:09 pm

1 stop6h 31m

Knoxville McGhee Tyson

Sun 9/27

5:38 pm-11:58 am

1 stop19h 20m

$265

San AntonioKnoxville

SAT San Antonio - TYS Knoxville McGhee Tyson

SATTYS

San Antonio

Mon 9/14

5:35 am-1:25 pm

1 stop6h 50m

Knoxville McGhee Tyson

Fri 9/18

1:00 pm-10:05 pm

1 stop10h 05m

$292

San AntonioKnoxville

SAT San Antonio - TYS Knoxville McGhee Tyson

SATTYS

San Antonio

Fri 9/11

7:10 am-1:25 pm

1 stop5h 15m

Knoxville McGhee Tyson

Fri 9/18

1:00 pm-10:05 pm

1 stop10h 05m

$292
Quickest round-trip

San AntonioKnoxville

SAT San Antonio - TYS Knoxville McGhee Tyson

SATTYS

San Antonio

Sat 8/29

5:54 pm-11:18 pm

1 stop4h 24m

Knoxville McGhee Tyson

Sat 9/5

11:49 am-3:50 pm

1 stop5h 01m

$303

San AntonioKnoxville

SAT San Antonio - TYS Knoxville McGhee Tyson

SATTYS

San Antonio

Sat 8/29

11:34 am-8:53 pm

2 stops8h 19m

Knoxville McGhee Tyson

Sat 9/5

2:21 pm-5:44 pm

1 stop4h 23m

$308

San AntonioKnoxville

SAT San Antonio - TYS Knoxville McGhee Tyson

SATTYS

San Antonio

Tue 9/15

5:30 pm-12:23 am

1 stop5h 53m

Knoxville McGhee Tyson

Mon 9/21

6:02 pm-10:51 pm

1 stop5h 49m

$319

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from San Antonio to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Antonio and Knoxville?

Prices are currently low for flights on this route.

Typical prices usually range from $292 to $390.
The lowest price recently found on this route was $251.

What is the cheapest month to fly to Knoxville?

The month of May is, on average, the cheapest month to fly to Knoxville from San Antonio, with most prices found around $287. If you aren’t able to travel during the month of May, then book flights to Knoxville from San Antonio during October instead. Flights to Knoxville in October, while not as cheap as those in May, still average around $298.

How far in advance should I book a flight from San Antonio to Knoxville?

You are more likely to see cheaper flights to Knoxville from San Antonio when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $390 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from San Antonio for as low as $229 on momondo.

How have San Antonio to Knoxville flight prices changed over time?

As of August 2026, prices for San Antonio to Knoxville flights are approximately 19% more expensive when compared to flights at the same time last year.

When to book flights from San Antonio to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Antonio to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Antonio to Knoxville (SAT to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Antonio to Knoxville

Fastest flight time

4h 15m

Direct flights

None
The fastest flight from San Antonio to Knoxville takes 4h 15m
There are no direct flights from San Antonio to Knoxville. There are no popular flight routes from San Antonio to Knoxville.
Search flight deals

Frequently asked questions about flying from San Antonio to Knoxville

  • How far is San Antonio to Knoxville McGhee Tyson by plane?

    A flight from San Antonio to Knoxville McGhee Tyson will travel around 958.1 mi. 4h 15m is a normal flight duration for this route.

  • When did momondo last update prices for flights from San Antonio Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Antonio Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from San Antonio Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Antonio Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Antonio Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from San Antonio to Knoxville?

Best airlines flying from San Antonio to Knoxville

Compare and see reviews for airlines that fly from San Antonio to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $144Free CancellationRating
7.8
8,505 reviews
Search Delta flights
United AirlinesPriceFrom $168Free CancellationRating
7.4
10,103 reviews
Search United Airlines flights
SouthwestPriceFrom $242Free CancellationRating
8.0
4,221 reviews
Search Southwest flights
American AirlinesPriceFrom $256Free CancellationRating
7.1
11,902 reviews
Search American Airlines flights

  • United Airlines Flights From San Antonio to Knoxville

    United Airlines flight deals from San Antonio to Knoxville start from $168 round-trip. Over the 1 United Airlines flight for this route in a normal week, average airfare is usually $336 round-trip - but some users have found much cheaper deals with momondo.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Dandridge
Lenoir City
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from San Antonio to Knoxville?

It is quick and easy to find San Antonio to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from San Antonio to Knoxville with flexible booking policies on momondo?

Flights from San Antonio to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Antonio to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from San Antonio. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from San Antonio to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Antonio to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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