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Cheap flights from San Antonio to Knoxville from $141

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Antonio to Knoxville departing on 4/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from San Antonio to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
12:35 pm - 7:40 pm
SAT
-
TYS
6h 05m
1 stop
Southwest Logo
5:40 pm - 11:10 pm
TYS
-
SAT
6h 30m
1 stop
$190Southwest
Tue, Apr 21 - Sat, Apr 25
Southwest Logo
12:45 pm - 7:40 pm
SAT
-
TYS
5h 55m
2 stops
Southwest Logo
6:40 am - 10:20 am
TYS
-
SAT
4h 40m
1 stop
$195Southwest
Tue, Apr 21 - Sat, Apr 25
Southwest Logo
11:20 am - 7:40 pm
SAT
-
TYS
7h 20m
2 stops
Southwest Logo
6:40 am - 12:25 pm
TYS
-
SAT
6h 45m
2 stops
$201Southwest
Tue, Apr 21 - Sat, Apr 25
Delta Logo
5:20 am - 11:17 am
SAT
-
TYS
4h 57m
1 stop
Delta Logo
4:38 pm - 8:30 pm
TYS
-
SAT
4h 52m
1 stop
$217Delta
Tue, May 5 - Wed, May 6
United Airlines Logo
5:18 pm - 12:30 am
SAT
-
TYS
6h 12m
1 stop
United Airlines Logo
5:57 pm - 10:55 pm
TYS
-
SAT
5h 58m
1 stop
$218United Airlines
Wed, May 27 - Sat, May 30
Delta Logo
5:20 am - 11:17 am
SAT
-
TYS
4h 57m
1 stop
Delta Logo
5:40 am - 9:52 am
TYS
-
SAT
5h 12m
1 stop
$219Delta
Tue, May 5 - Sat, May 9
Frontier Logo
6:45 am - 3:28 pm
SAT
-
TYS
7h 43m
1 stop
Frontier Logo
4:28 pm - 2:15 pm
TYS
-
SAT
22h 47m
1 stop
$226Frontier
Mon, Apr 6 - Thu, Apr 16
Delta Logo
5:20 am - 11:17 am
SAT
-
TYS
4h 57m
1 stop
Delta Logo
7:33 pm - 12:44 am
TYS
-
SAT
6h 11m
1 stop
$232Delta
Tue, May 5 - Thu, May 7
Delta Logo
5:25 am - 11:09 am
SAT
-
TYS
4h 44m
1 stop
Delta Logo
7:33 pm - 12:44 am
TYS
-
SAT
6h 11m
1 stop
$234Delta
Sat, May 9 - Mon, May 11
Frontier Logo
6:45 am - 3:28 pm
SAT
-
TYS
7h 43m
1 stop
Frontier Logo
4:20 pm - 12:19 am
TYS
-
SAT
8h 59m
1 stop
$235Frontier
Mon, Apr 6 - Fri, Apr 10

Southwest flights from San Antonio to Knoxville

Our best Southwest deals on San Antonio to Knoxville flight tickets
Southwest
Apr 21
SAT12:35 pmSan Antonio
6h 05m
1 stop
TYS7:40 pmKnoxville McGhee Tyson
Apr 25
TYS5:40 pmKnoxville McGhee Tyson
6h 30m
1 stop
SAT11:10 pmSan Antonio
$190
Southwest
Apr 21
SAT12:45 pmSan Antonio
5h 55m
2 stops
TYS7:40 pmKnoxville McGhee Tyson
Apr 25
TYS6:40 amKnoxville McGhee Tyson
4h 40m
1 stop
SAT10:20 amSan Antonio
$195
Southwest
Apr 21
SAT11:20 amSan Antonio
7h 20m
2 stops
TYS7:40 pmKnoxville McGhee Tyson
Apr 25
TYS6:40 amKnoxville McGhee Tyson
6h 45m
2 stops
SAT12:25 pmSan Antonio
$201

American Airlines flights from San Antonio to Knoxville

Our best American Airlines deals on San Antonio to Knoxville flight tickets
American Airlines
Apr 22
SAT5:00 amSan Antonio
6h 30m
1 stop
TYS12:30 pmKnoxville McGhee Tyson
Apr 29
TYS6:54 pmKnoxville McGhee Tyson
4h 58m
1 stop
SAT10:52 pmSan Antonio
$245
American Airlines
Apr 15
SAT7:00 amSan Antonio
4h 30m
1 stop
TYS12:30 pmKnoxville McGhee Tyson
Apr 15
TYS6:54 pmKnoxville McGhee Tyson
6h 02m
1 stop
SAT11:56 pmSan Antonio
$257
American Airlines
May 23
SAT5:35 pmSan Antonio
5h 18m
1 stop
TYS11:53 pmKnoxville McGhee Tyson
May 30
TYS8:11 pmKnoxville McGhee Tyson
4h 48m
1 stop
SAT11:59 pmSan Antonio
$258

momondo Fare Finder

 
Customize your flight search to find flights from San Antonio to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 24, 2026.
Use the filters below to find and compare flights from San Antonio to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Tue 4/21

12:35 pm-7:40 pm

1 stop6h 05m

Knoxville McGhee Tyson

Sat 4/25

5:40 pm-11:10 pm

1 stop6h 30m

$190

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Tue 4/21

12:45 pm-7:40 pm

2 stops5h 55m

Knoxville McGhee Tyson

Sat 4/25

6:40 am-10:20 am

1 stop4h 40m

$195

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Tue 4/21

11:20 am-7:40 pm

2 stops7h 20m

Knoxville McGhee Tyson

Sat 4/25

6:40 am-12:25 pm

2 stops6h 45m

$201
Quickest round-trip

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Tue 5/5

5:20 am-11:17 am

1 stop4h 57m

Knoxville McGhee Tyson

Wed 5/6

4:38 pm-8:30 pm

1 stop4h 52m

$217

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Wed 5/27

5:18 pm-12:30 am

1 stop6h 12m

Knoxville McGhee Tyson

Sat 5/30

5:57 pm-10:55 pm

1 stop5h 58m

$218

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Tue 5/5

5:20 am-11:17 am

1 stop4h 57m

Knoxville McGhee Tyson

Sat 5/9

5:40 am-9:52 am

1 stop5h 12m

$219

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Mon 4/6

6:45 am-3:28 pm

1 stop7h 43m

Knoxville McGhee Tyson

Thu 4/16

4:28 pm-2:15 pm

1 stop22h 47m

$226

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Tue 5/5

5:20 am-11:17 am

1 stop4h 57m

Knoxville McGhee Tyson

Thu 5/7

7:33 pm-12:44 am

1 stop6h 11m

$232

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Sat 5/9

5:25 am-11:09 am

1 stop4h 44m

Knoxville McGhee Tyson

Mon 5/11

7:33 pm-12:44 am

1 stop6h 11m

$234

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Mon 4/6

6:45 am-3:28 pm

1 stop7h 43m

Knoxville McGhee Tyson

Fri 4/10

4:20 pm-12:19 am

1 stop8h 59m

$235

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from San Antonio to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of October is, on average, the cheapest month to fly to Knoxville from San Antonio, with most prices found around $277. If you aren’t able to travel during the month of October, then book flights to Knoxville from San Antonio during January instead. Flights to Knoxville in January, while not as cheap as those in October, still average around $283.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from San Antonio when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $351 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from San Antonio for as low as $223 on momondo.

How have San Antonio to Knoxville flight prices changed over time?

As of March 2026, prices for San Antonio to Knoxville flights are approximately 40% more expensive when compared to flights at the same time last year.

When to book flights from San Antonio to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Antonio to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Antonio to Knoxville (SAT to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Antonio to Knoxville

Fastest flight time

4h 17m

Direct flights

None
The fastest flight from San Antonio to Knoxville takes 4h 17m
There are no direct flights from San Antonio to Knoxville. There are no popular flight routes from San Antonio to Knoxville.
Search flight deals

  • How far is San Antonio to Knoxville McGhee Tyson by plane?

    A flight from San Antonio to Knoxville McGhee Tyson will travel around 958.1 mi. 4h 17m is a normal flight duration for this route.

  • When did momondo last update prices for flights from San Antonio Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Antonio Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from San Antonio Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Antonio Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Antonio Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from San Antonio to Knoxville?

Best airlines flying from San Antonio to Knoxville

Compare and see reviews for airlines that fly from San Antonio to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $144Free CancellationRating
7.9
8,320 reviews
Search Delta flights
American AirlinesPriceFrom $216Free CancellationRating
7.1
11,492 reviews
Search American Airlines flights
United AirlinesPriceFrom $293Free CancellationRating
7.4
9,467 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Jefferson City
Dandridge
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from San Antonio to Knoxville?

It is quick and easy to find San Antonio to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from San Antonio to Knoxville with flexible booking policies on momondo?

Flights from San Antonio to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Antonio to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from San Antonio. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from San Antonio to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Antonio to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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