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Cheap flights from San Antonio to Knoxville from $148

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Antonio to Knoxville departing on 9/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from San Antonio to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
7:49 pm - 7:24 pm
SAT
-
TYS
22h 35m
1 stop
Frontier Logo
8:19 pm - 6:54 pm
TYS
-
SAT
23h 35m
1 stop
$264Frontier
Thu, Aug 13 - Mon, Aug 17
Delta Logo
5:30 am - 11:06 am
SAT
-
TYS
4h 36m
1 stop
Delta Logo
8:47 am - 3:28 pm
TYS
-
SAT
7h 41m
1 stop
$295Delta
Tue, Oct 20 - Tue, Oct 27
Southwest Logo
8:05 am - 2:10 pm
SAT
-
TYS
5h 05m
1 stop
Southwest Logo
4:10 pm - 9:35 pm
TYS
-
SAT
6h 25m
1 stop
$298Southwest
Sat, Dec 12 - Mon, Dec 14
Southwest Logo
10:50 am - 6:55 pm
SAT
-
TYS
7h 05m
1 stop
Southwest Logo
12:45 pm - 8:30 pm
TYS
-
SAT
8h 45m
2 stops
$300Southwest
Wed, Aug 5 - Tue, Aug 11
Southwest Logo
8:05 am - 5:40 pm
SAT
-
TYS
8h 35m
2 stops
Southwest Logo
4:10 pm - 9:35 pm
TYS
-
SAT
6h 25m
1 stop
$303Southwest
Sat, Dec 12 - Mon, Dec 14
Southwest Logo
9:20 am - 6:55 pm
SAT
-
TYS
8h 35m
2 stops
Southwest Logo
12:45 pm - 8:30 pm
TYS
-
SAT
8h 45m
2 stops
$305Southwest
Wed, Aug 5 - Tue, Aug 11
Delta Logo
8:00 am - 3:05 pm
SAT
-
TYS
6h 05m
1 stop
Delta Logo
3:55 pm - 8:22 pm
TYS
-
SAT
5h 27m
1 stop
$312Delta
Thu, Oct 15 - Wed, Oct 21
Southwest Logo
12:20 pm - 5:40 pm
SAT
-
TYS
4h 20m
1 stop
Southwest Logo
1:00 pm - 10:00 pm
TYS
-
SAT
10h 00m
1 stop
$317Southwest
Sat, Sep 26 - Mon, Sep 28
Southwest Logo
6:10 am - 1:15 pm
SAT
-
TYS
6h 05m
2 stops
Southwest Logo
1:00 pm - 10:00 pm
TYS
-
SAT
10h 00m
1 stop
$323Southwest
Sat, Sep 26 - Mon, Sep 28
Delta Logo
8:00 am - 3:05 pm
SAT
-
TYS
6h 05m
1 stop
Delta Logo
8:47 am - 3:28 pm
TYS
-
SAT
7h 41m
1 stop
$336Delta
Sun, Oct 25 - Sat, Oct 31

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United Airlines flights from San Antonio to Knoxville

Our best United Airlines deals on San Antonio to Knoxville flight tickets
United Airlines
Aug 11
SAT2:15 pmSan Antonio
6h 30m
1 stop
TYS9:45 pmKnoxville McGhee Tyson
Aug 12
TYS2:21 pmKnoxville McGhee Tyson
6h 37m
1 stop
SAT7:58 pmSan Antonio
$375
United Airlines
Oct 20
SAT4:17 pmSan Antonio
4h 38m
1 stop
TYS9:55 pmKnoxville McGhee Tyson
Oct 27
TYS7:00 amKnoxville McGhee Tyson
9h 42m
2 stops
SAT3:42 pmSan Antonio
$380
United Airlines
Oct 20
SAT9:48 amSan Antonio
10h 12m
2 stops
TYS9:00 pmKnoxville McGhee Tyson
Oct 27
TYS7:00 amKnoxville McGhee Tyson
9h 42m
2 stops
SAT3:42 pmSan Antonio
$386

Delta flights from San Antonio to Knoxville

Our best Delta deals on San Antonio to Knoxville flight tickets
Delta
Oct 20
SAT5:30 amSan Antonio
4h 36m
1 stop
TYS11:06 amKnoxville McGhee Tyson
Oct 27
TYS8:47 amKnoxville McGhee Tyson
7h 41m
1 stop
SAT3:28 pmSan Antonio
$295
Delta
Oct 15
SAT8:00 amSan Antonio
6h 05m
1 stop
TYS3:05 pmKnoxville McGhee Tyson
Oct 21
TYS3:55 pmKnoxville McGhee Tyson
5h 27m
1 stop
SAT8:22 pmSan Antonio
$312
Delta
Oct 25
SAT8:00 amSan Antonio
6h 05m
1 stop
TYS3:05 pmKnoxville McGhee Tyson
Oct 31
TYS8:47 amKnoxville McGhee Tyson
7h 41m
1 stop
SAT3:28 pmSan Antonio
$336

momondo Fare Finder

 
Customize your flight search to find flights from San Antonio to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 27, 2026.
Use the filters below to find and compare flights from San Antonio to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Thu 8/13

7:49 pm-7:24 pm

1 stop22h 35m

Knoxville McGhee Tyson

Mon 8/17

8:19 pm-6:54 pm

1 stop23h 35m

$264

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Tue 10/20

5:30 am-11:06 am

1 stop4h 36m

Knoxville McGhee Tyson

Tue 10/27

8:47 am-3:28 pm

1 stop7h 41m

$295
Quickest round-trip

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Sat 12/12

8:05 am-2:10 pm

1 stop5h 05m

Knoxville McGhee Tyson

Mon 12/14

4:10 pm-9:35 pm

1 stop6h 25m

$298

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Wed 8/5

10:50 am-6:55 pm

1 stop7h 05m

Knoxville McGhee Tyson

Tue 8/11

12:45 pm-8:30 pm

2 stops8h 45m

$300

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Sat 12/12

8:05 am-5:40 pm

2 stops8h 35m

Knoxville McGhee Tyson

Mon 12/14

4:10 pm-9:35 pm

1 stop6h 25m

$303

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Wed 8/5

9:20 am-6:55 pm

2 stops8h 35m

Knoxville McGhee Tyson

Tue 8/11

12:45 pm-8:30 pm

2 stops8h 45m

$305

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Thu 10/15

8:00 am-3:05 pm

1 stop6h 05m

Knoxville McGhee Tyson

Wed 10/21

3:55 pm-8:22 pm

1 stop5h 27m

$312

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Sat 9/26

12:20 pm-5:40 pm

1 stop4h 20m

Knoxville McGhee Tyson

Mon 9/28

1:00 pm-10:00 pm

1 stop10h 00m

$317

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Sat 9/26

6:10 am-1:15 pm

2 stops6h 05m

Knoxville McGhee Tyson

Mon 9/28

1:00 pm-10:00 pm

1 stop10h 00m

$323

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Sun 10/25

8:00 am-3:05 pm

1 stop6h 05m

Knoxville McGhee Tyson

Sat 10/31

8:47 am-3:28 pm

1 stop7h 41m

$336

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from San Antonio to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Antonio and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of October is, on average, the cheapest month to fly to Knoxville from San Antonio, with most prices found around $283. If you aren’t able to travel during the month of October, then book flights to Knoxville from San Antonio during January instead. Flights to Knoxville in January, while not as cheap as those in October, still average around $283.

How far in advance should I book a flight from San Antonio to Knoxville?

You are more likely to see cheaper flights to Knoxville from San Antonio when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $379 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from San Antonio for as low as $246 on momondo.

How have San Antonio to Knoxville flight prices changed over time?

As of June 2026, prices for San Antonio to Knoxville flights are approximately 62% more expensive when compared to flights at the same time last year.

When to book flights from San Antonio to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Antonio to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Antonio to Knoxville (SAT to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Antonio to Knoxville

Fastest flight time

4h 15m

Direct flights

None
The fastest flight from San Antonio to Knoxville takes 4h 15m
There are no direct flights from San Antonio to Knoxville. There are no popular flight routes from San Antonio to Knoxville.
Search flight deals

Frequently asked questions about flying from San Antonio to Knoxville

  • How far is San Antonio to Knoxville McGhee Tyson by plane?

    A flight from San Antonio to Knoxville McGhee Tyson will travel around 958.1 mi. 4h 15m is a normal flight duration for this route.

  • When did momondo last update prices for flights from San Antonio Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Antonio Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from San Antonio Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Antonio Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Antonio Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from San Antonio to Knoxville?

Best airlines flying from San Antonio to Knoxville

Compare and see reviews for airlines that fly from San Antonio to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $144Free CancellationRating
7.8
8,451 reviews
Search Delta flights
United AirlinesPriceFrom $168Free CancellationRating
7.4
9,896 reviews
Search United Airlines flights
American AirlinesPriceFrom $216Free CancellationRating
7.1
11,779 reviews
Search American Airlines flights
SouthwestPriceFrom $242Free CancellationRating
7.9
4,246 reviews
Search Southwest flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Murphy
Crossville
Oak Ridge
Kodak
Newport
Lenoir City
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from San Antonio to Knoxville?

It is quick and easy to find San Antonio to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from San Antonio to Knoxville with flexible booking policies on momondo?

Flights from San Antonio to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Antonio to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from San Antonio. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from San Antonio to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Antonio to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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