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Cheap flights from San Antonio to Knoxville from $129

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Antonio to Knoxville departing on 11/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:14 am - 11:31 amSAT-TYS
4h 17m1 stop
American Airlines Logo
4:16 pm - 8:49 pmTYS-SAT
5h 33m1 stop
$217American Airlines
Find Deal
Sat, Jan 10 - Sat, Jan 24
Delta Logo
5:20 am - 11:47 amSAT-TYS
5h 27m1 stop
Delta Logo
10:05 am - 3:31 pmTYS-SAT
6h 26m1 stop
$237Delta
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
6:48 am - 3:54 pmSAT-TYS
8h 06m1 stop
American Airlines Logo
5:05 am - 11:09 amTYS-SAT
7h 04m1 stop
$243American Airlines
Find Deal
Wed, Dec 3 - Sun, Dec 7
American Airlines Logo
6:05 am - 1:36 pmSAT-TYS
6h 31m1 stop
American Airlines Logo
5:10 am - 9:46 amTYS-SAT
5h 36m1 stop
$248American Airlines
Find Deal
Wed, Oct 29 - Wed, Nov 12
Delta Logo
11:50 am - 8:00 pmSAT-TYS
7h 10m1 stop
Delta Logo
3:56 pm - 9:03 pmTYS-SAT
6h 07m1 stop
$253Delta
Find Deal
Thu, Nov 20 - Wed, Dec 3
Delta Logo
6:41 am - 2:43 pmSAT-TYS
7h 02m1 stop
Delta Logo
6:35 am - 11:55 amTYS-SAT
6h 20m1 stop
$258Delta
Find Deal
Tue, Oct 28 - Wed, Nov 12
Multiple Airlines Logo
3:23 pm - 3:53 pmSAT-TYS
23h 30m1 stop
Multiple Airlines Logo
6:30 am - 6:19 pmTYS-SAT
12h 49m1 stop
$264Multiple Airlines
Find Deal
Thu, Nov 20 - Thu, Dec 4
Multiple Airlines Logo
3:12 pm - 2:33 pmSAT-TYS
22h 21m1 stop
Multiple Airlines Logo
4:32 pm - 6:32 pmTYS-SAT
27h 00m1 stop
$267Multiple Airlines
Find Deal
Sat, Nov 1 - Wed, Nov 5
United Airlines Logo
2:25 pm - 7:52 pmSAT-TYS
4h 27m1 stop
United Airlines Logo
8:26 am - 4:20 pmTYS-SAT
8h 54m1 stop
$279United Airlines
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Sat, Oct 25 - Fri, Oct 31
United Airlines Logo
11:40 am - 6:04 pmSAT-TYS
5h 24m1 stop
United Airlines Logo
1:52 pm - 9:20 pmTYS-SAT
8h 28m2 stops
$284United Airlines
Find Deal
Tue, Oct 28 - Sat, Nov 1

American Airlines flights from San Antonio to Knoxville

Our best American Airlines deals on San Antonio to Knoxville flight tickets
American Airlines
Jan 10
SAT6:14 amSan Antonio
4h 17m
1 stop
TYS11:31 amKnoxville McGhee Tyson
Jan 24
TYS4:16 pmKnoxville McGhee Tyson
5h 33m
1 stop
SAT8:49 pmSan Antonio
$217
Find similar
American Airlines
Dec 3
SAT6:48 amSan Antonio
8h 06m
1 stop
TYS3:54 pmKnoxville McGhee Tyson
Dec 7
TYS5:05 amKnoxville McGhee Tyson
7h 04m
1 stop
SAT11:09 amSan Antonio
$243
Find similar
American Airlines
Oct 29
SAT6:05 amSan Antonio
6h 31m
1 stop
TYS1:36 pmKnoxville McGhee Tyson
Nov 12
TYS5:10 amKnoxville McGhee Tyson
5h 36m
1 stop
SAT9:46 amSan Antonio
$248
Find similar

Delta flights from San Antonio to Knoxville

Our best Delta deals on San Antonio to Knoxville flight tickets
Delta
Feb 21
SAT5:20 amSan Antonio
5h 27m
1 stop
TYS11:47 amKnoxville McGhee Tyson
Feb 25
TYS10:05 amKnoxville McGhee Tyson
6h 26m
1 stop
SAT3:31 pmSan Antonio
$237
Find similar
Delta
Nov 20
SAT11:50 amSan Antonio
7h 10m
1 stop
TYS8:00 pmKnoxville McGhee Tyson
Dec 3
TYS3:56 pmKnoxville McGhee Tyson
6h 07m
1 stop
SAT9:03 pmSan Antonio
$253
Find similar
Delta
Oct 28
SAT6:41 amSan Antonio
7h 02m
1 stop
TYS2:43 pmKnoxville McGhee Tyson
Nov 12
TYS6:35 amKnoxville McGhee Tyson
6h 20m
1 stop
SAT11:55 amSan Antonio
$258
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Antonio to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 14, 2025.
Use the filters below to find and compare flights from San Antonio to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Sat 1/10

6:14 am-11:31 am

1 stop4h 17m

Knoxville McGhee Tyson

Sat 1/24

4:16 pm-8:49 pm

1 stop5h 33m

$217

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Sat 2/21

5:20 am-11:47 am

1 stop5h 27m

Knoxville McGhee Tyson

Wed 2/25

10:05 am-3:31 pm

1 stop6h 26m

$237

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Wed 12/3

6:48 am-3:54 pm

1 stop8h 06m

Knoxville McGhee Tyson

Sun 12/7

5:05 am-11:09 am

1 stop7h 04m

$243

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Wed 10/29

6:05 am-1:36 pm

1 stop6h 31m

Knoxville McGhee Tyson

Wed 11/12

5:10 am-9:46 am

1 stop5h 36m

$248

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Thu 11/20

11:50 am-8:00 pm

1 stop7h 10m

Knoxville McGhee Tyson

Wed 12/3

3:56 pm-9:03 pm

1 stop6h 07m

$253

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Tue 10/28

6:41 am-2:43 pm

1 stop7h 02m

Knoxville McGhee Tyson

Wed 11/12

6:35 am-11:55 am

1 stop6h 20m

$258

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Thu 11/20

3:23 pm-3:53 pm

1 stop23h 30m

Knoxville McGhee Tyson

Thu 12/4

6:30 am-6:19 pm

1 stop12h 49m

$264

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Sat 11/1

3:12 pm-2:33 pm

1 stop22h 21m

Knoxville McGhee Tyson

Wed 11/5

4:32 pm-6:32 pm

1 stop27h 00m

$267

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Sat 10/25

2:25 pm-7:52 pm

1 stop4h 27m

Knoxville McGhee Tyson

Fri 10/31

8:26 am-4:20 pm

1 stop8h 54m

$279

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Tue 10/28

11:40 am-6:04 pm

1 stop5h 24m

Knoxville McGhee Tyson

Sat 11/1

1:52 pm-9:20 pm

2 stops8h 28m

$284

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from San Antonio to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from San Antonio, with most prices found around $258. If you aren’t able to travel during the month of January, then book flights to Knoxville from San Antonio during October instead. Flights to Knoxville in October, while not as cheap as those in January, still average around $278.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from San Antonio to Knoxville is on a Wednesday. Travelers who choose to depart for Knoxville on a Wednesday will often find tickets for as low as $288. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from San Antonio to Knoxville for around $510.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from San Antonio to Knoxville when you can find flight prices for as low as $268. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $358.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from San Antonio when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $350 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from San Antonio for as low as $257 on momondo.

How have San Antonio to Knoxville flight prices changed over time?

As of October 2025, prices for San Antonio to Knoxville flights are approximately 3% more expensive when compared to flights at the same time last year.

When to book flights from San Antonio to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Antonio to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Antonio to Knoxville (SAT to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Antonio to Knoxville

Direct flights

None
There are no direct flights from San Antonio to Knoxville. There are no popular flight routes from San Antonio to Knoxville.
Search flight deals

  • How far is San Antonio to Knoxville McGhee Tyson by plane?

    A flight from San Antonio to Knoxville McGhee Tyson will travel around 958.1 mi. 4h 17m is a normal flight duration for this route.

  • When did momondo last update prices for flights from San Antonio Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Antonio Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from San Antonio Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Antonio Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Antonio Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from San Antonio to Knoxville?

Best airlines flying from San Antonio to Knoxville

Compare and see reviews for airlines that fly from San Antonio to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $144Free CancellationRating
7.9
7,975 reviews
Search Delta flights
American AirlinesPriceFrom $220Free CancellationRating
7.2
11,042 reviews
Search American Airlines flights
United AirlinesPriceFrom $259Free CancellationRating
7.4
8,976 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from San Antonio to Knoxville?

It is quick and easy to find San Antonio to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from San Antonio to Knoxville with flexible booking policies on momondo?

Flights from San Antonio to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Antonio to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from San Antonio. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from San Antonio to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Antonio to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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