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Cheap flights from San Antonio to Knoxville from $115

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from San Antonio to Knoxville departing on 6/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from San Antonio to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
7:51 pm - 7:37 pm
SAT
-
TYS
22h 46m
1 stop
Frontier Logo
8:32 pm - 6:56 pm
TYS
-
SAT
23h 24m
1 stop
$210Frontier
Thu, Jun 11 - Wed, Jun 17
American Airlines Logo
3:56 pm - 11:30 pm
SAT
-
TYS
6h 34m
1 stop
American Airlines Logo
5:37 pm - 10:55 pm
TYS
-
SAT
6h 18m
1 stop
$257American Airlines
Tue, Oct 20 - Tue, Oct 27
Frontier Logo
7:51 pm - 7:37 pm
SAT
-
TYS
22h 46m
1 stop
Frontier Logo
8:32 pm - 6:56 pm
TYS
-
SAT
23h 24m
1 stop
$260Frontier
Thu, Jun 11 - Mon, Jun 15
Delta Logo
5:30 am - 12:24 pm
SAT
-
TYS
5h 54m
1 stop
Delta Logo
5:30 am - 11:10 am
TYS
-
SAT
6h 40m
1 stop
$267Delta
Sat, Sep 5 - Tue, Sep 8
Frontier Logo
7:51 pm - 7:37 pm
SAT
-
TYS
22h 46m
1 stop
Frontier Logo
8:32 pm - 6:56 pm
TYS
-
SAT
23h 24m
1 stop
$275Frontier
Sun, Jun 21 - Fri, Jun 26
Delta Logo
7:40 am - 1:19 pm
SAT
-
TYS
4h 39m
1 stop
Delta Logo
5:40 am - 9:52 am
TYS
-
SAT
5h 12m
1 stop
$290Delta
Mon, Jun 29 - Fri, Jul 3
American Airlines Logo
5:01 am - 11:13 am
SAT
-
TYS
5h 12m
1 stop
American Airlines Logo
10:00 am - 4:57 pm
TYS
-
SAT
7h 57m
1 stop
$293American Airlines
Mon, Jun 29 - Fri, Jul 3
Delta Logo
5:20 am - 11:05 am
SAT
-
TYS
4h 45m
1 stop
Delta Logo
5:40 am - 9:43 am
TYS
-
SAT
5h 03m
1 stop
$298Delta
Wed, Jul 8 - Sun, Jul 12
Southwest Logo
3:45 pm - 10:30 pm
SAT
-
TYS
5h 45m
1 stop
Southwest Logo
2:45 pm - 10:20 pm
TYS
-
SAT
8h 35m
2 stops
$305Southwest
Mon, Jun 8 - Tue, Jun 16
Delta Logo
6:50 am - 2:33 pm
SAT
-
TYS
6h 43m
1 stop
Delta Logo
6:08 pm - 12:33 am
TYS
-
SAT
7h 25m
1 stop
$312Delta
Tue, Jun 2 - Mon, Jun 29

Southwest flights from San Antonio to Knoxville

Our best Southwest deals on San Antonio to Knoxville flight tickets
Southwest
Jun 8
SAT3:45 pmSan Antonio
5h 45m
1 stop
TYS10:30 pmKnoxville McGhee Tyson
Jun 16
TYS2:45 pmKnoxville McGhee Tyson
8h 35m
2 stops
SAT10:20 pmSan Antonio
$305
Southwest
Oct 20
SAT7:10 amSan Antonio
8h 35m
2 stops
TYS4:45 pmKnoxville McGhee Tyson
Oct 27
TYS7:00 amKnoxville McGhee Tyson
4h 15m
1 stop
SAT10:15 amSan Antonio
$318
Southwest
Oct 20
SAT12:00 pmSan Antonio
8h 15m
2 stops
TYS9:15 pmKnoxville McGhee Tyson
Oct 27
TYS7:00 amKnoxville McGhee Tyson
6h 15m
2 stops
SAT12:15 pmSan Antonio
$336

Frontier flights from San Antonio to Knoxville

Our best Frontier deals on San Antonio to Knoxville flight tickets
Frontier
Jun 11
SAT7:51 pmSan Antonio
22h 46m
1 stop
TYS7:37 pmKnoxville McGhee Tyson
Jun 17
TYS8:32 pmKnoxville McGhee Tyson
23h 24m
1 stop
SAT6:56 pmSan Antonio
$210
Frontier
Jun 11
SAT7:51 pmSan Antonio
22h 46m
1 stop
TYS7:37 pmKnoxville McGhee Tyson
Jun 17
TYS8:32 pmKnoxville McGhee Tyson
23h 24m
1 stop
SAT6:56 pmSan Antonio
$219
Frontier
Jun 11
SAT7:51 pmSan Antonio
22h 46m
1 stop
TYS7:37 pmKnoxville McGhee Tyson
Jun 15
TYS8:32 pmKnoxville McGhee Tyson
23h 24m
1 stop
SAT6:56 pmSan Antonio
$260

momondo Fare Finder

 
Customize your flight search to find flights from San Antonio to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 14, 2026.
Use the filters below to find and compare flights from San Antonio to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Thu 6/11

7:51 pm-7:37 pm

1 stop22h 46m

Knoxville McGhee Tyson

Wed 6/17

8:32 pm-6:56 pm

1 stop23h 24m

$210

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Tue 10/20

3:56 pm-11:30 pm

1 stop6h 34m

Knoxville McGhee Tyson

Tue 10/27

5:37 pm-10:55 pm

1 stop6h 18m

$257

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Thu 6/11

7:51 pm-7:37 pm

1 stop22h 46m

Knoxville McGhee Tyson

Mon 6/15

8:32 pm-6:56 pm

1 stop23h 24m

$260

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Sat 9/5

5:30 am-12:24 pm

1 stop5h 54m

Knoxville McGhee Tyson

Tue 9/8

5:30 am-11:10 am

1 stop6h 40m

$267

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Sun 6/21

7:51 pm-7:37 pm

1 stop22h 46m

Knoxville McGhee Tyson

Fri 6/26

8:32 pm-6:56 pm

1 stop23h 24m

$275

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Mon 6/29

7:40 am-1:19 pm

1 stop4h 39m

Knoxville McGhee Tyson

Fri 7/3

5:40 am-9:52 am

1 stop5h 12m

$290

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Mon 6/29

5:01 am-11:13 am

1 stop5h 12m

Knoxville McGhee Tyson

Fri 7/3

10:00 am-4:57 pm

1 stop7h 57m

$293
Quickest round-trip

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Wed 7/8

5:20 am-11:05 am

1 stop4h 45m

Knoxville McGhee Tyson

Sun 7/12

5:40 am-9:43 am

1 stop5h 03m

$298

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Mon 6/8

3:45 pm-10:30 pm

1 stop5h 45m

Knoxville McGhee Tyson

Tue 6/16

2:45 pm-10:20 pm

2 stops8h 35m

$305

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Tue 6/2

6:50 am-2:33 pm

1 stop6h 43m

Knoxville McGhee Tyson

Mon 6/29

6:08 pm-12:33 am

1 stop7h 25m

$312

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from San Antonio to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between San Antonio and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of October is, on average, the cheapest month to fly to Knoxville from San Antonio, with most prices found around $278. If you aren’t able to travel during the month of October, then book flights to Knoxville from San Antonio during January instead. Flights to Knoxville in January, while not as cheap as those in October, still average around $283.

How far in advance should I book a flight from San Antonio to Knoxville?

You are more likely to see cheaper flights to Knoxville from San Antonio when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $358 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from San Antonio for as low as $276 on momondo.

How have San Antonio to Knoxville flight prices changed over time?

As of May 2026, prices for San Antonio to Knoxville flights are approximately 49% more expensive when compared to flights at the same time last year.

When to book flights from San Antonio to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Antonio to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Antonio to Knoxville (SAT to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Antonio to Knoxville

Fastest flight time

4h 15m

Direct flights

None
The fastest flight from San Antonio to Knoxville takes 4h 15m
There are no direct flights from San Antonio to Knoxville. There are no popular flight routes from San Antonio to Knoxville.
Search flight deals

Frequently asked questions about flying from San Antonio to Knoxville

  • How far is San Antonio to Knoxville McGhee Tyson by plane?

    A flight from San Antonio to Knoxville McGhee Tyson will travel around 958.1 mi. 4h 15m is a normal flight duration for this route.

  • When did momondo last update prices for flights from San Antonio Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Antonio Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from San Antonio Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Antonio Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Antonio Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from San Antonio to Knoxville?

Best airlines flying from San Antonio to Knoxville

Compare and see reviews for airlines that fly from San Antonio to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $144Free CancellationRating
7.9
8,454 reviews
Search Delta flights
American AirlinesPriceFrom $216Free CancellationRating
7.1
11,664 reviews
Search American Airlines flights
SouthwestPriceFrom $216Free CancellationRating
8.0
4,299 reviews
Search Southwest flights
United AirlinesPriceFrom $278Free CancellationRating
7.4
9,711 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Crossville
Maryville
Murphy
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from San Antonio to Knoxville?

It is quick and easy to find San Antonio to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from San Antonio to Knoxville with flexible booking policies on momondo?

Flights from San Antonio to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Antonio to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from San Antonio. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from San Antonio to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Antonio to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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