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Cheap flights from San Antonio to Knoxville from $217

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from San Antonio to Knoxville departing on 10/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from San Antonio to Knoxville

Cheap round-trip flights

American Airlines Logo
7:00 am - 1:13 pmSAT-TYS
5h 13m1 stop
American Airlines Logo
12:35 pm - 6:40 pmTYS-SAT
7h 05m1 stop
$217American Airlines
Find Deal
Wed, Oct 1 - Wed, Oct 8
Delta Logo
11:35 am - 9:13 pmSAT-TYS
8h 38m1 stop
Delta Logo
7:30 am - 12:51 pmTYS-SAT
6h 21m1 stop
$237Delta
Find Deal
Wed, Oct 15 - Sat, Nov 15
Delta Logo
12:15 pm - 8:02 pmSAT-TYS
6h 47m1 stop
Delta Logo
8:10 pm - 12:20 amTYS-SAT
5h 10m1 stop
$249Delta
Find Deal
Thu, Oct 2 - Mon, Oct 6
Delta Logo
6:41 am - 2:43 pmSAT-TYS
7h 02m1 stop
Delta Logo
8:10 pm - 12:20 amTYS-SAT
5h 10m1 stop
$269Delta
Find Deal
Wed, Oct 22 - Mon, Oct 27
Logo
2:54 pm - 9:54 amSAT-TYS
18h 00m1 stop
Logo
9:26 pm - 4:47 amTYS-SAT
32h 21m2 stops
$280
Find Deal
Thu, Oct 2 - Mon, Oct 6
United Airlines Logo
5:58 pm - 11:44 pmSAT-TYS
4h 46m1 stop
United Airlines Logo
5:35 pm - 10:59 pmTYS-SAT
6h 24m1 stop
$287United Airlines
Find Deal
Thu, Sep 4 - Sat, Sep 6
American Airlines Logo
7:08 am - 1:43 pmSAT-TYS
5h 35m1 stop
American Airlines Logo
11:07 am - 6:42 pmTYS-SAT
8h 35m2 stops
$292American Airlines
Find Deal
Thu, Sep 4 - Sat, Sep 6
Logo
3:22 pm - 1:43 pmSAT-TYS
21h 21m1 stop
Logo
7:00 am - 7:15 pmTYS-SAT
13h 15m1 stop
$293
Find Deal
Sat, Sep 6 - Thu, Sep 11
American Airlines Logo
12:44 pm - 11:03 pmSAT-TYS
9h 19m2 stops
American Airlines Logo
6:25 am - 2:43 pmTYS-SAT
9h 18m2 stops
$297American Airlines
Find Deal
Fri, Sep 5 - Sat, Sep 6
United Airlines Logo
5:58 pm - 11:44 pmSAT-TYS
4h 46m1 stop
United Airlines Logo
7:00 am - 3:26 pmTYS-SAT
9h 26m2 stops
$308United Airlines
Find Deal
Fri, Sep 5 - Thu, Sep 11

American Airlines flights from San Antonio to Knoxville

Our best American Airlines deals on San Antonio to Knoxville flight tickets
American Airlines
Oct 1
SAT7:00 amSan Antonio
5h 13m
1 stop
TYS1:13 pmKnoxville McGhee Tyson
Oct 8
TYS12:35 pmKnoxville McGhee Tyson
7h 05m
1 stop
SAT6:40 pmSan Antonio
$217
Find similar
American Airlines
Sep 4
SAT7:08 amSan Antonio
5h 35m
1 stop
TYS1:43 pmKnoxville McGhee Tyson
Sep 6
TYS11:07 amKnoxville McGhee Tyson
8h 35m
2 stops
SAT6:42 pmSan Antonio
$292
Find similar
American Airlines
Sep 5
SAT12:44 pmSan Antonio
9h 19m
2 stops
TYS11:03 pmKnoxville McGhee Tyson
Sep 6
TYS6:25 amKnoxville McGhee Tyson
9h 18m
2 stops
SAT2:43 pmSan Antonio
$297
Find similar

United Airlines flights from San Antonio to Knoxville

Our best United Airlines deals on San Antonio to Knoxville flight tickets
United Airlines
Sep 4
SAT5:58 pmSan Antonio
4h 46m
1 stop
TYS11:44 pmKnoxville McGhee Tyson
Sep 6
TYS5:35 pmKnoxville McGhee Tyson
6h 24m
1 stop
SAT10:59 pmSan Antonio
$287
Find similar
United Airlines
Sep 5
SAT5:58 pmSan Antonio
4h 46m
1 stop
TYS11:44 pmKnoxville McGhee Tyson
Sep 11
TYS7:00 amKnoxville McGhee Tyson
9h 26m
2 stops
SAT3:26 pmSan Antonio
$308
Find similar
United Airlines
Sep 6
SAT5:30 amSan Antonio
10h 30m
2 stops
TYS5:00 pmKnoxville McGhee Tyson
Sep 9
TYS7:20 amKnoxville McGhee Tyson
7h 02m
1 stop
SAT1:22 pmSan Antonio
$313
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from San Antonio to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 21, 2025.
Use the filters below to find and compare flights from San Antonio to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Wed 10/1

7:00 am-1:13 pm

1 stop5h 13m

Knoxville McGhee Tyson

Wed 10/8

12:35 pm-6:40 pm

1 stop7h 05m

$217

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Wed 10/15

11:35 am-9:13 pm

1 stop8h 38m

Knoxville McGhee Tyson

Sat 11/15

7:30 am-12:51 pm

1 stop6h 21m

$237

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Thu 10/2

12:15 pm-8:02 pm

1 stop6h 47m

Knoxville McGhee Tyson

Mon 10/6

8:10 pm-12:20 am

1 stop5h 10m

$249

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Wed 10/22

6:41 am-2:43 pm

1 stop7h 02m

Knoxville McGhee Tyson

Mon 10/27

8:10 pm-12:20 am

1 stop5h 10m

$269

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Thu 10/2

2:54 pm-9:54 am

1 stop18h 00m

Knoxville McGhee Tyson

Mon 10/6

9:26 pm-4:47 am

2 stops32h 21m

$280

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Thu 9/4

5:58 pm-11:44 pm

1 stop4h 46m

Knoxville McGhee Tyson

Sat 9/6

5:35 pm-10:59 pm

1 stop6h 24m

$287

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Thu 9/4

7:08 am-1:43 pm

1 stop5h 35m

Knoxville McGhee Tyson

Sat 9/6

11:07 am-6:42 pm

2 stops8h 35m

$292

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Sat 9/6

3:22 pm-1:43 pm

1 stop21h 21m

Knoxville McGhee Tyson

Thu 9/11

7:00 am-7:15 pm

1 stop13h 15m

$293

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Fri 9/5

12:44 pm-11:03 pm

2 stops9h 19m

Knoxville McGhee Tyson

Sat 9/6

6:25 am-2:43 pm

2 stops9h 18m

$297

San AntonioKnoxville

SAT - TYS

SATTYS

San Antonio

Fri 9/5

5:58 pm-11:44 pm

1 stop4h 46m

Knoxville McGhee Tyson

Thu 9/11

7:00 am-3:26 pm

2 stops9h 26m

$308

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from San Antonio to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from San Antonio, with most prices found around $258. If you aren’t able to travel during the month of January, then book flights to Knoxville from San Antonio during August instead. Flights to Knoxville in August, while not as cheap as those in January, still average around $306.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from San Antonio to Knoxville is on a Wednesday. Travelers who choose to depart for Knoxville on a Wednesday will often find tickets for as low as $288. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from San Antonio to Knoxville for around $510.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from San Antonio to Knoxville when you can find flight prices for as low as $268. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $358.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from San Antonio when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $360 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from San Antonio for as low as $225 on momondo.

How have San Antonio to Knoxville flight prices changed over time?

As of August 2025, prices for San Antonio to Knoxville flights are approximately 10% cheaper when compared to flights at the same time last year.

When to book flights from San Antonio to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from San Antonio to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap San Antonio to Knoxville (SAT to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from San Antonio to Knoxville

Direct flights

None
There are no direct flights from San Antonio to Knoxville. There are no popular flight routes from San Antonio to Knoxville.
Search flight deals

  • How far is San Antonio to Knoxville McGhee Tyson by plane?

    A flight from San Antonio to Knoxville McGhee Tyson will travel around 958.1 mi. 4h 45m is a normal flight duration for this route.

  • When did momondo last update prices for flights from San Antonio Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from San Antonio Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from San Antonio Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from San Antonio Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from San Antonio Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from San Antonio to Knoxville?

Best airlines flying from San Antonio to Knoxville

Compare and see reviews for airlines that fly from San Antonio to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $232Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $236Free CancellationRating
7.9
7,981 reviews
Search Delta flights
United AirlinesPriceFrom $259Free CancellationRating
7.4
8,930 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Newport
Lenoir City
Alcoa
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from San Antonio to Knoxville?

It is quick and easy to find San Antonio to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from San Antonio to Knoxville with flexible booking policies on momondo?

Flights from San Antonio to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from San Antonio to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from San Antonio. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from San Antonio to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for San Antonio to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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