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Cheap flights from Portland, Maine to Greenville from $149

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Portland, Maine to Greenville departing on 3/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Portland, Maine to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Breeze Airways Logo
3:11 pm - 7:11 pm
PWM
-
GSP
4h 00m
1 stop
Breeze Airways Logo
10:35 am - 2:26 pm
GSP
-
PWM
3h 51m
1 stop
$286Breeze Airways
Sun, May 10 - Sun, May 17
American Airlines Logo
6:00 am - 10:19 am
PWM
-
GSP
4h 19m
1 stop
American Airlines Logo
7:37 pm - 11:55 pm
GSP
-
PWM
4h 18m
1 stop
$297American Airlines
Tue, Mar 3 - Mon, Mar 9
Delta Logo
12:43 pm - 8:19 pm
PWM
-
GSP
7h 36m
2 stops
Delta Logo
6:21 pm - 11:12 pm
GSP
-
PWM
4h 51m
1 stop
$302Delta
Tue, Mar 3 - Mon, Mar 9
United Airlines Logo
6:04 am - 11:44 am
PWM
-
GSP
5h 40m
1 stop
United Airlines Logo
6:30 am - 3:22 pm
GSP
-
PWM
8h 52m
1 stop
$313United Airlines
Thu, Apr 23 - Tue, Apr 28
American Airlines Logo
5:07 pm - 11:12 pm
PWM
-
GSP
6h 05m
2 stops
American Airlines Logo
7:37 pm - 11:55 pm
GSP
-
PWM
4h 18m
1 stop
$336American Airlines
Tue, Mar 3 - Mon, Mar 9
United Airlines Logo
6:00 am - 11:21 am
PWM
-
GSP
5h 21m
1 stop
United Airlines Logo
6:30 am - 3:14 pm
GSP
-
PWM
8h 44m
1 stop
$338United Airlines
Wed, Feb 18 - Wed, Feb 25
Delta Logo
5:31 am - 11:13 am
PWM
-
GSP
5h 42m
1 stop
Delta Logo
5:40 am - 12:00 pm
GSP
-
PWM
6h 20m
2 stops
$343Delta
Wed, Feb 18 - Wed, Feb 25
American Airlines Logo
6:00 am - 10:19 am
PWM
-
GSP
4h 19m
1 stop
American Airlines Logo
6:13 am - 11:34 am
GSP
-
PWM
5h 21m
1 stop
$344American Airlines
Wed, Feb 25 - Sun, Mar 1
Southwest Logo
5:45 am - 5:40 pm
PWM
-
GSP
11h 55m
2 stops
Southwest Logo
6:25 am - 4:45 pm
GSP
-
PWM
10h 20m
2 stops
$353Southwest
Tue, Mar 3 - Mon, Mar 9
Delta Logo
5:31 am - 11:13 am
PWM
-
GSP
5h 42m
1 stop
Delta Logo
5:41 pm - 11:22 pm
GSP
-
PWM
5h 41m
1 stop
$358Delta
Fri, Mar 6 - Mon, Mar 9

Breeze Airways flights from Portland, Maine to Greenville

Our best Breeze Airways deals on Portland, Maine to Greenville flight tickets
Breeze Airways
May 10
PWM3:11 pmPortland
4h 00m
1 stop
GSP7:11 pmGreenville
May 17
GSP10:35 amGreenville
3h 51m
1 stop
PWM2:26 pmPortland
$286
Breeze Airways
May 10
PWM7:56 pmPortland
23h 52m
3 stops
GSP7:48 pmGreenville
May 17
GSP7:51 pmGreenville
18h 18m
3 stops
PWM2:09 pmPortland
$638

American Airlines flights from Portland, Maine to Greenville

Our best American Airlines deals on Portland, Maine to Greenville flight tickets
American Airlines
Mar 3
PWM6:00 amPortland
4h 19m
1 stop
GSP10:19 amGreenville
Mar 9
GSP7:37 pmGreenville
4h 18m
1 stop
PWM11:55 pmPortland
$297
American Airlines
Mar 3
PWM5:07 pmPortland
6h 05m
2 stops
GSP11:12 pmGreenville
Mar 9
GSP7:37 pmGreenville
4h 18m
1 stop
PWM11:55 pmPortland
$336
American Airlines
Mar 27
PWM6:00 amPortland
4h 20m
1 stop
GSP10:20 amGreenville
Mar 29
GSP6:00 amGreenville
5h 19m
1 stop
PWM11:19 amPortland
$407

momondo Fare Finder

 
Customize your flight search to find flights from Portland, Maine to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Portland, Maine to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Sun 5/10

3:11 pm-7:11 pm

1 stop4h 00m

Greenville

Sun 5/17

10:35 am-2:26 pm

1 stop3h 51m

$286

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Tue 3/3

6:00 am-10:19 am

1 stop4h 19m

Greenville

Mon 3/9

7:37 pm-11:55 pm

1 stop4h 18m

$297

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Tue 3/3

12:43 pm-8:19 pm

2 stops7h 36m

Greenville

Mon 3/9

6:21 pm-11:12 pm

1 stop4h 51m

$302

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Thu 4/23

6:04 am-11:44 am

1 stop5h 40m

Greenville

Tue 4/28

6:30 am-3:22 pm

1 stop8h 52m

$313

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Tue 3/3

5:07 pm-11:12 pm

2 stops6h 05m

Greenville

Mon 3/9

7:37 pm-11:55 pm

1 stop4h 18m

$336

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Wed 2/18

6:00 am-11:21 am

1 stop5h 21m

Greenville

Wed 2/25

6:30 am-3:14 pm

1 stop8h 44m

$338

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Wed 2/18

5:31 am-11:13 am

1 stop5h 42m

Greenville

Wed 2/25

5:40 am-12:00 pm

2 stops6h 20m

$343

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Wed 2/25

6:00 am-10:19 am

1 stop4h 19m

Greenville

Sun 3/1

6:13 am-11:34 am

1 stop5h 21m

$344

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Tue 3/3

5:45 am-5:40 pm

2 stops11h 55m

Greenville

Mon 3/9

6:25 am-4:45 pm

2 stops10h 20m

$353

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Fri 3/6

5:31 am-11:13 am

1 stop5h 42m

Greenville

Mon 3/9

5:41 pm-11:22 pm

1 stop5h 41m

$358

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Portland, Maine to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Greenville?

The month of August is another great option to travel to Greenville, with average flight prices from Portland, Maine averaging around $311.

How have Portland, Maine to Greenville flight prices changed over time?

When to book flights from Portland, Maine to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Portland, Maine to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Portland, Maine to Greenville (PWM to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Portland, Maine to Greenville

Fastest flight time

4h 00m

Direct flights

None
The fastest flight from Portland, Maine to Greenville takes 4h 00m
There are no direct flights from Portland, Maine to Greenville. There are no popular flight routes from Portland, Maine to Greenville.
Search flight deals

  • How far is Portland to Greenville by plane?

    Portland and Greenville are 887.7 mi apart from one another. 4h 00m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Portland Airport to Greenville Airport?

    Prices for flights from Portland Airport to Greenville Airport refresh daily.

  • How many operators does momondo search for flights from Portland Airport to Greenville Airport?

  • How old do you have to be to fly from Portland Airport to Greenville Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Portland Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The required travel and health documents for your Greenville Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Greenville Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Portland, Maine to Greenville?

Best airlines flying from Portland, Maine to Greenville

Compare and see reviews for airlines that fly from Portland, Maine to Greenville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $213Free CancellationRating
7.9
8,138 reviews
Search Delta flights
American AirlinesPriceFrom $258Free CancellationRating
7.2
11,216 reviews
Search American Airlines flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Seneca
Greer
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Portland to Greenville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Portland to Greenville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Portland to Greenville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Greenville from Portland which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Portland to Greenville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Portland to Greenville.

I’m not ready to book a flight from Portland to Greenville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Portland to Greenville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Greenville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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