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Cheap flights from Portland, Maine to Greenville from $132

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Portland, Maine to Greenville departing on 4/29. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Portland, Maine to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:00 am - 10:54 am
PWM
-
GSP
4h 54m
1 stop
Delta Logo
6:00 am - 10:52 am
GSP
-
PWM
4h 52m
1 stop
$263Delta
Wed, Apr 29 - Wed, May 6
Delta Logo
6:00 am - 12:05 pm
PWM
-
GSP
6h 05m
1 stop
Delta Logo
6:14 pm - 11:18 pm
GSP
-
PWM
5h 04m
1 stop
$290Delta
Sat, May 16 - Tue, May 19
Delta Logo
5:21 am - 10:20 am
PWM
-
GSP
4h 59m
1 stop
Delta Logo
6:00 am - 11:02 am
GSP
-
PWM
5h 02m
1 stop
$317Delta
Mon, Apr 13 - Mon, Apr 20
Delta Logo
5:21 am - 10:20 am
PWM
-
GSP
4h 59m
1 stop
Delta Logo
6:00 am - 11:02 am
GSP
-
PWM
5h 02m
1 stop
$320Delta
Wed, Apr 22 - Wed, Apr 29
Delta Logo
6:00 am - 10:54 am
PWM
-
GSP
4h 54m
1 stop
Delta Logo
6:00 am - 10:17 am
GSP
-
PWM
4h 17m
1 stop
$335Delta
Tue, May 5 - Sun, May 10
American Airlines Logo
10:24 am - 5:39 pm
PWM
-
GSP
7h 15m
1 stop
American Airlines Logo
6:28 pm - 11:27 pm
GSP
-
PWM
4h 59m
1 stop
$336American Airlines
Wed, May 13 - Sat, May 16
American Airlines Logo
3:40 pm - 11:57 pm
PWM
-
GSP
8h 17m
2 stops
American Airlines Logo
6:00 am - 12:38 pm
GSP
-
PWM
6h 38m
1 stop
$338American Airlines
Sat, May 16 - Tue, May 19
Southwest Logo
3:55 pm - 8:00 pm
PWM
-
GSP
4h 05m
1 stop
Southwest Logo
6:25 am - 4:00 pm
GSP
-
PWM
9h 35m
2 stops
$341Southwest
Wed, May 13 - Sat, May 16
Delta Logo
1:23 pm - 7:15 pm
PWM
-
GSP
5h 52m
1 stop
Delta Logo
6:00 am - 10:23 am
GSP
-
PWM
4h 23m
1 stop
$344Delta
Sat, May 2 - Fri, May 8
Southwest Logo
1:00 pm - 9:40 pm
PWM
-
GSP
8h 40m
2 stops
Southwest Logo
6:25 am - 4:00 pm
GSP
-
PWM
9h 35m
2 stops
$346Southwest
Wed, May 13 - Sat, May 16

American Airlines flights from Portland, Maine to Greenville

Our best American Airlines deals on Portland, Maine to Greenville flight tickets
American Airlines
May 13
PWM10:24 amPortland
7h 15m
1 stop
GSP5:39 pmGreenville
May 16
GSP6:28 pmGreenville
4h 59m
1 stop
PWM11:27 pmPortland
$336
American Airlines
May 16
PWM3:40 pmPortland
8h 17m
2 stops
GSP11:57 pmGreenville
May 19
GSP6:00 amGreenville
6h 38m
1 stop
PWM12:38 pmPortland
$338
American Airlines
Apr 14
PWM3:39 pmPortland
6h 40m
1 stop
GSP10:19 pmGreenville
Apr 22
GSP5:20 amGreenville
5h 55m
1 stop
PWM11:15 amPortland
$355

Southwest flights from Portland, Maine to Greenville

Our best Southwest deals on Portland, Maine to Greenville flight tickets
Southwest
May 13
PWM3:55 pmPortland
4h 05m
1 stop
GSP8:00 pmGreenville
May 16
GSP6:25 amGreenville
9h 35m
2 stops
PWM4:00 pmPortland
$341
Southwest
May 13
PWM1:00 pmPortland
8h 40m
2 stops
GSP9:40 pmGreenville
May 16
GSP6:25 amGreenville
9h 35m
2 stops
PWM4:00 pmPortland
$346
Southwest
Apr 8
PWM3:55 pmPortland
4h 05m
1 stop
GSP8:00 pmGreenville
Apr 14
GSP12:50 pmGreenville
9h 45m
2 stops
PWM10:35 pmPortland
$387

momondo Fare Finder

 
Customize your flight search to find flights from Portland, Maine to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 25, 2026.
Use the filters below to find and compare flights from Portland, Maine to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Wed 4/29

6:00 am-10:54 am

1 stop4h 54m

Greenville

Wed 5/6

6:00 am-10:52 am

1 stop4h 52m

$263

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Sat 5/16

6:00 am-12:05 pm

1 stop6h 05m

Greenville

Tue 5/19

6:14 pm-11:18 pm

1 stop5h 04m

$290

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Mon 4/13

5:21 am-10:20 am

1 stop4h 59m

Greenville

Mon 4/20

6:00 am-11:02 am

1 stop5h 02m

$317

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Wed 4/22

5:21 am-10:20 am

1 stop4h 59m

Greenville

Wed 4/29

6:00 am-11:02 am

1 stop5h 02m

$320
Quickest round-trip

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Tue 5/5

6:00 am-10:54 am

1 stop4h 54m

Greenville

Sun 5/10

6:00 am-10:17 am

1 stop4h 17m

$335

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Wed 5/13

10:24 am-5:39 pm

1 stop7h 15m

Greenville

Sat 5/16

6:28 pm-11:27 pm

1 stop4h 59m

$336

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Sat 5/16

3:40 pm-11:57 pm

2 stops8h 17m

Greenville

Tue 5/19

6:00 am-12:38 pm

1 stop6h 38m

$338

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Wed 5/13

3:55 pm-8:00 pm

1 stop4h 05m

Greenville

Sat 5/16

6:25 am-4:00 pm

2 stops9h 35m

$341

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Sat 5/2

1:23 pm-7:15 pm

1 stop5h 52m

Greenville

Fri 5/8

6:00 am-10:23 am

1 stop4h 23m

$344

PortlandGreenville

PWM - GSP

PWMGSP

Portland

Wed 5/13

1:00 pm-9:40 pm

2 stops8h 40m

Greenville

Sat 5/16

6:25 am-4:00 pm

2 stops9h 35m

$346

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Portland, Maine to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Portland, Maine and Greenville?

How have Portland, Maine to Greenville flight prices changed over time?

When to book flights from Portland, Maine to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Portland, Maine to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Portland, Maine to Greenville (PWM to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Portland, Maine to Greenville

Fastest flight time

4h 05m

Direct flights

None
The fastest flight from Portland, Maine to Greenville takes 4h 05m
There are no direct flights from Portland, Maine to Greenville. There are no popular flight routes from Portland, Maine to Greenville.
Search flight deals

  • How far is Portland to Greenville by plane?

    Portland and Greenville are 887.7 mi apart from one another. 4h 05m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Portland Airport to Greenville Airport?

    Prices for flights from Portland Airport to Greenville Airport refresh daily.

  • How many operators does momondo search for flights from Portland Airport to Greenville Airport?

  • How old do you have to be to fly from Portland Airport to Greenville Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Portland Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The required travel and health documents for your Greenville Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Greenville Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Portland, Maine to Greenville?

Best airlines flying from Portland, Maine to Greenville

Compare and see reviews for airlines that fly from Portland, Maine to Greenville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $213Free CancellationRating
7.9
8,327 reviews
Search Delta flights
American AirlinesPriceFrom $258Free CancellationRating
7.1
11,494 reviews
Search American Airlines flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Greer
Seneca
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Portland to Greenville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Portland to Greenville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Portland to Greenville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Greenville from Portland which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Portland to Greenville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Portland to Greenville.

I’m not ready to book a flight from Portland to Greenville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Portland to Greenville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Greenville trip

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