Cheap flights from Pittsburgh to St. Louis from $101

In general, November is the cheapest month to fly from Pittsburgh to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $286. The month of August is another great option to travel to St. Louis, with average flight prices from Pittsburgh averaging around $298.

The cheapest day to depart on your flight to St. Louis is on a Tuesday when prices can be found for as low as $397. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Friday because tickets tend to average around $461. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

Flying to St. Louis from Pittsburgh in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $384 when looking at flights departing in the afternoon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $447 per ticket.

Fly from Pittsburgh to Lambert-St Louis for the best Pittsburgh - Lambert-St Louis flight prices

You are more likely to see cheaper flights to St. Louis from Pittsburgh when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $366 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from Pittsburgh for as low as $253 on momondo.

There is only 1 cabin class available to choose from on Pittsburgh to St. Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 11% on your flight if you consider stops on a Pittsburgh to St. Louis flight.

As of September 2026, prices for Pittsburgh to St. Louis flights are approximately 32% cheaper when compared to flights at the same time last year.

Delta is the most popular carrier operating from Pittsburgh to Lambert-St Louis

Southwest, American Airlines and United Airlines are the top three most popular airlines that fly to St. Louis from Pittsburgh according to our data. Southwest is the first choice among our users, with 69% of people opting to fly with this airline when traveling to St. Louis. Keep in mind that there are 4 different airlines that fly to St. Louis on a routine basis, so you have a few additional options to choose from.

Chicago (ORD) was the most common stop: 50% of momondo users choosing 1-stop flights on this route connected there.

Flights via Chicago (ORD) offer the lowest average round-trip price of $330.

Flights connecting via Detroit (DTW) have the shortest average one-way travel time: 4h 13m.

Detroit (DTW) has the shortest average layover time for this route: 1h 04m.