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Cheap flights from Philadelphia to Florence from $381

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Philadelphia to Florence departing on 2/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Philadelphia to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:35 pm - 10:42 pm
PHL
-
FLO
5h 07m
1 stop
American Airlines Logo
5:24 am - 9:36 am
FLO
-
PHL
4h 12m
1 stop
$423American Airlines
Tue, Apr 21 - Wed, Apr 29
American Airlines Logo
10:30 am - 3:32 pm
PHL
-
FLO
5h 02m
1 stop
American Airlines Logo
5:24 am - 12:43 pm
FLO
-
PHL
7h 19m
2 stops
$428American Airlines
Tue, Apr 21 - Wed, Apr 29
American Airlines Logo
3:10 pm - 10:42 pm
PHL
-
FLO
7h 32m
2 stops
American Airlines Logo
5:24 am - 12:43 pm
FLO
-
PHL
7h 19m
2 stops
$434American Airlines
Tue, Apr 21 - Wed, Apr 29
American Airlines Logo
5:38 pm - 11:08 pm
PHL
-
FLO
5h 30m
1 stop
American Airlines Logo
6:20 pm - 10:04 pm
FLO
-
PHL
3h 44m
1 stop
$492American Airlines
Wed, Feb 25 - Sun, Mar 1
American Airlines Logo
3:14 pm - 11:08 pm
PHL
-
FLO
7h 54m
2 stops
American Airlines Logo
6:20 pm - 10:04 pm
FLO
-
PHL
3h 44m
1 stop
$497American Airlines
Wed, Feb 25 - Sun, Mar 1
American Airlines Logo
1:48 pm - 5:50 pm
PHL
-
FLO
4h 02m
1 stop
American Airlines Logo
6:20 pm - 10:04 pm
FLO
-
PHL
3h 44m
1 stop
$499American Airlines
Fri, Feb 27 - Mon, Mar 2
American Airlines Logo
4:45 pm - 11:57 pm
PHL
-
FLO
7h 12m
2 stops
American Airlines Logo
5:16 am - 9:45 am
FLO
-
PHL
4h 29m
1 stop
$545American Airlines
Fri, Feb 27 - Mon, Mar 2
American Airlines Logo
3:14 pm - 11:08 pm
PHL
-
FLO
7h 54m
2 stops
American Airlines Logo
5:16 am - 12:42 pm
FLO
-
PHL
7h 26m
2 stops
$579American Airlines
Wed, Feb 25 - Sun, Mar 1
American Airlines Logo
10:25 am - 5:09 pm
PHL
-
FLO
6h 44m
1 stop
American Airlines Logo
6:15 am - 10:23 am
FLO
-
PHL
4h 08m
1 stop
$581American Airlines
Thu, Feb 5 - Mon, Feb 9
American Airlines Logo
3:35 pm - 10:43 pm
PHL
-
FLO
7h 08m
2 stops
American Airlines Logo
6:15 am - 10:23 am
FLO
-
PHL
4h 08m
1 stop
$586American Airlines
Thu, Feb 5 - Mon, Feb 9

American Airlines flights from Philadelphia to Florence, South Carolina

Our best American Airlines deals on Philadelphia to Florence, South Carolina flight tickets
American Airlines
Apr 21
PHL5:35 pmPhiladelphia
5h 07m
1 stop
FLO10:42 pmFlorence
Apr 29
FLO5:24 amFlorence
4h 12m
1 stop
PHL9:36 amPhiladelphia
$423
American Airlines
Apr 21
PHL10:30 amPhiladelphia
5h 02m
1 stop
FLO3:32 pmFlorence
Apr 29
FLO5:24 amFlorence
7h 19m
2 stops
PHL12:43 pmPhiladelphia
$428
American Airlines
Apr 21
PHL3:10 pmPhiladelphia
7h 32m
2 stops
FLO10:42 pmFlorence
Apr 29
FLO5:24 amFlorence
7h 19m
2 stops
PHL12:43 pmPhiladelphia
$434

momondo Fare Finder

 
Customize your flight search to find flights from Philadelphia to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 21, 2026.
Use the filters below to find and compare flights from Philadelphia to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

PhiladelphiaFlorence

PHL - FLO

PHLFLO

Philadelphia

Tue 4/21

5:35 pm-10:42 pm

1 stop5h 07m

Florence

Wed 4/29

5:24 am-9:36 am

1 stop4h 12m

$423

PhiladelphiaFlorence

PHL - FLO

PHLFLO

Philadelphia

Tue 4/21

10:30 am-3:32 pm

1 stop5h 02m

Florence

Wed 4/29

5:24 am-12:43 pm

2 stops7h 19m

$428

PhiladelphiaFlorence

PHL - FLO

PHLFLO

Philadelphia

Tue 4/21

3:10 pm-10:42 pm

2 stops7h 32m

Florence

Wed 4/29

5:24 am-12:43 pm

2 stops7h 19m

$434

PhiladelphiaFlorence

PHL - FLO

PHLFLO

Philadelphia

Wed 2/25

5:38 pm-11:08 pm

1 stop5h 30m

Florence

Sun 3/1

6:20 pm-10:04 pm

1 stop3h 44m

$492

PhiladelphiaFlorence

PHL - FLO

PHLFLO

Philadelphia

Wed 2/25

3:14 pm-11:08 pm

2 stops7h 54m

Florence

Sun 3/1

6:20 pm-10:04 pm

1 stop3h 44m

$497

PhiladelphiaFlorence

PHL - FLO

PHLFLO

Philadelphia

Fri 2/27

1:48 pm-5:50 pm

1 stop4h 02m

Florence

Mon 3/2

6:20 pm-10:04 pm

1 stop3h 44m

$499

PhiladelphiaFlorence

PHL - FLO

PHLFLO

Philadelphia

Fri 2/27

4:45 pm-11:57 pm

2 stops7h 12m

Florence

Mon 3/2

5:16 am-9:45 am

1 stop4h 29m

$545

PhiladelphiaFlorence

PHL - FLO

PHLFLO

Philadelphia

Wed 2/25

3:14 pm-11:08 pm

2 stops7h 54m

Florence

Sun 3/1

5:16 am-12:42 pm

2 stops7h 26m

$579

PhiladelphiaFlorence

PHL - FLO

PHLFLO

Philadelphia

Thu 2/5

10:25 am-5:09 pm

1 stop6h 44m

Florence

Mon 2/9

6:15 am-10:23 am

1 stop4h 08m

$581

PhiladelphiaFlorence

PHL - FLO

PHLFLO

Philadelphia

Thu 2/5

3:35 pm-10:43 pm

2 stops7h 08m

Florence

Mon 2/9

6:15 am-10:23 am

1 stop4h 08m

$586

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Florence from

How to get the cheapest flight ticket from Philadelphia to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Philadelphia to Florence?

American Airlines is the most popular carrier operating from Philadelphia to Florence

What airlines fly to Florence, South Carolina?

American Airlines, Spirit Airlines and Frontier are the top three most popular airlines that fly to Florence, South Carolina from Philadelphia according to our data. American Airlines is the first choice among our users, with 35% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 9 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Philadelphia to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Philadelphia to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Philadelphia to Florence, South Carolina (PHL to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Philadelphia to Florence, South Carolina

Fastest flight time

4h 02m

Direct flights

None
The fastest flight from Philadelphia to Florence, South Carolina takes 4h 02m
There are no direct flights from Philadelphia to Florence, South Carolina. There are no popular flight routes from Philadelphia to Florence, South Carolina.
Search flight deals

  • How far is Philadelphia to Florence by plane?

    There are 471.6 mi between Philadelphia and Florence. By plane, this route typically takes 4h 02m.

  • When did momondo last update prices for flights from Philadelphia Airport to Florence Airport?

    Prices for flights from Philadelphia Airport to Florence Airport were last updated today.

  • How old do you have to be to fly from Philadelphia Airport to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Philadelphia Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents you'll need for your trip to Florence Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Florence Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Lake City
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Philadelphia to Florence?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Philadelphia to Florence. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Philadelphia to Florence with flexible booking policies on momondo?

momondo does allow users to show only those flights to Florence from Philadelphia which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Philadelphia to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Philadelphia to Florence.

I’m not ready to book a flight from Philadelphia to Florence right now. Can momondo alert me if prices change?

Price alerts on flights to Florence from Philadelphia are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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